RLCP codes/
links |
Overall reaction |
Ligand
types |
Catalysis
types |
Types of
catalytic sites |
Corresponding enzymes |
1.12.30000.10 | Hydrolysis | Carboxylic Ester (One of Carbonyl Ester bonds) | Trypsin-like mechanism | Ser/His/Asp + mainchain amide | S00345; Carboxylesterase 2
(Catalytic domain: 3.40.50.1820)
S00347; Bile salt-activated lipase
(Catalytic domain: 3.40.50.1820)
S00720; Arylesterase
(Catalytic domain: 3.40.50.1820)
S00723; Feruloyl esterase A
(Catalytic domain: 3.40.50.1820)
T00253; Pancreatic lipase-related protein 2
(Catalytic domain: 3.40.50.1820)
|
1.12.30000.14 | Hydrolysis | Carboxylic Ester (One of Carbonyl Ester bonds) | Trypsin-like mechanism | Ser/His/Glu + mainchain amide | S00057; Acetylcholinesterase
(Catalytic domain: 3.40.50.1820)
S00725; Cholinesterase
(Catalytic domain: 3.40.50.1820)
|
1.12.30000.24 | Hydrolysis | Carboxylic Ester (One of Carbonyl Ester bonds) | Trypsin-like mechanism | Ser/His/Asp + Asn/mainchain amide | S00361; Platelet-activating factor acetylhydrolase IB subunit gamma
(Catalytic domain: 3.40.50.1110)
|
1.12.30000.26 | Hydrolysis | Carboxylic Ester (One of Carbonyl Ester bonds) | Trypsin-like mechanism | Ser/His/Asp + Thr/mainchain amide | S00346; Acetylxylan esterase 2
(Catalytic domain: 3.40.50.1820)
|
1.12.30000.27 | Hydrolysis | Carboxylic Ester (One of Carbonyl Ester bonds) | Trypsin-like mechanism | Ser/His/Asp + Ser/mainchain amide | S00724; Cutinase 1
(Catalytic domain: 3.40.50.1820)
|
1.12.30000.45 | Hydrolysis | Carboxylic Ester (One of Carbonyl Ester bonds) | Trypsin-like mechanism | Cys/His/Asp + Gln/mainchain amide | S00524; Ubiquitin carboxyl-terminal hydrolase YUH1
(Catalytic domain: 3.40.532.10)
|
1.12.30190.70 | Hydrolysis | Carboxylic Ester (One of Carbonyl Ester bonds) | Pectinesterase A-like mechanism | Asp/Asp/Arg + Gln cluster | S00171; Pectinesterase A
(Catalytic domain: 2.160.20.10)
|
1.12.38700.511 | Hydrolysis | Carboxylic Ester (One of Carbonyl Ester bonds) | Phospholipase-A1-like mechanism | Ser/His/Asn + mainchain amide + calcium ion bound to mainchain carbonyl group and Ser | S00127; Phospholipase A1
(Catalytic domain: 2.40.230.10)
|
1.13.200.966 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | Pepsin-like mechanism | Two acidic residues (interacting through a water) | D00231; Saccharopepsin
(Catalytic domain: 2.40.70.10)
D00423; Chymosin
(Catalytic domain: 2.40.70.10)
D00436; Pepsin A
(Catalytic domain: 2.40.70.10)
D00437; Gastricsin
(Catalytic domain: 2.40.70.10)
D00438; Renin-2
(Catalytic domain: 2.40.70.10)
D00439; Penicillopepsin
(Catalytic domain: 2.40.70.10)
D00440; Rhizopuspepsin
(Catalytic domain: 2.40.70.10)
D00441; Endothiapepsin
(Catalytic domain: 2.40.70.10)
D00442; Mucorpepsin
(Catalytic domain: 2.40.70.10)
D00443; Candidapepsin
(Catalytic domain: 2.40.70.10)
D00444; Plasmepsin-2
(Catalytic domain: 2.40.70.10)
D00445; Phytepsin
(Catalytic domain: 2.40.70.10)
D00462; Peptide-N(4)-(N-acetyl-beta-D-glucosaminyl)asparagine amidase F
(Catalytic domain: 2.60.120.230)
D00471; Gag-Pol polyprotein
(Catalytic domain: 2.40.70.10)
D00484; Cathepsin D
(Catalytic domain: 2.40.70.10)
D00529; Pepsin-2B
(Catalytic domain: 2.40.70.10)
M00166; Gag-Pol polyprotein
(Catalytic domains: 2.40.70.10, 3.30.70.270, 3.30.420.10)
M00206; Pol polyprotein
(Catalytic domains: 2.40.70.10, 2.70.40.10)
|
1.13.7495.453 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | E.coli N-Acetyl-D-glucosamine-6-phosphate deacetylase-like mechanism | An acidic residue + His + zinc ion bound to His/(acidic residue) cluster | D00801; N-acetylglucosamine-6-phosphate deacetylase
(Catalytic domain: 3.20.20.140)
|
1.13.7500.450 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | One zinc beta-lactamase mechanism | An acidic residue + [Asn or Gln] + zinc ion bound to His/Cys/Asp cluster | S00432; Beta-lactamase 2
(Catalytic domain: 3.60.15.10)
|
1.13.7630.541 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | N-Acetylglucosamine-6-phosphate deacetylase-like mechanism | An acidic residue + Two Fe ions bound to His/Asp/Glu cluster | D00673; N-acetylglucosamine-6-phosphate deacetylase
(Catalytic domain: 3.20.20.140)
|
1.13.10000.1220 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | Two zinc beta-lactamase mechanism | Asn + two zinc ions bound to His/Cys/Asp cluster | S00515; Beta-lactamase type II
(Catalytic domain: 3.60.15.10)
|
1.13.10880.280 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | Muramoyl-pentapeptide-carboxypeptidase-like mechanism | His/Asp + His/Tyr + zinc ion bound to His/His/Asp | D00191; Zinc D-Ala-D-Ala carboxypeptidase
(Catalytic domain: 3.30.1380.10)
|
1.13.10900.463 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | Thermolysin-like mechanism | Glu + His/Tyr/Asn + mainchain carbonyl + zinc ion bound to His/Glu cluster | D00233; Pseudolysin
(Catalytic domains: 1.10.390.10, 3.10.170.10)
D00234; Thermolysin
(Catalytic domains: 1.10.390.10, 3.10.170.10)
D00235; Bacillolysin
(Catalytic domains: 1.10.390.10, 3.10.170.10)
D00480; Zinc metalloproteinase aureolysin
(Catalytic domains: 1.10.390.10, 3.10.170.10)
|
1.13.10900.462 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | Thermolysin-like mechanism | Glu + Asn + mainchain carbonyl + zinc ion bound to His cluster | D00232; Interstitial collagenase
(Catalytic domain: 3.40.390.10)
|
1.13.11100.261 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | Serralysin-like mechanism | Glu/Tyr + zinc ion bound to His cluster | D00236; Serralysin
(Catalytic domain: 3.40.390.10)
S00394; Astacin
(Catalytic domain: 3.40.390.10)
|
1.13.11100.285 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | Serralysin-like mechanism | Tyr/Lys + zinc ion bound to His/His/Cys | S00502; N-acetylmuramoyl-L-alanine amidase
(Catalytic domain: 3.40.80.10)
|
1.13.11100.286 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | Serralysin-like mechanism | Tyr/His + zinc ion bound to His/His/Cys | S00536; Peptidoglycan-recognition protein-LB
(Catalytic domain: 3.40.80.10)
|
1.13.11100.561 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | Serralysin-like mechanism | Glu/Gln + mainchain amide + Fe(II) bound to Cys/His/His | S00442; Peptide deformylase
(Catalytic domain: 3.90.45.10)
|
1.13.11110.262 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | Carboxypeptidase A-like mechanism | An acidic residue + Arg + mainchain carbonyl + zinc ion bound to His/Glu cluster | D00193; Carboxypeptidase A2
(Catalytic domain: 3.40.630.10)
D00467; Carboxypeptidase A
(Catalytic domain: 3.40.630.10)
D00512; Carboxypeptidase B
(Catalytic domain: 3.40.630.10)
S00407; Carboxypeptidase T
(Catalytic domain: 3.40.630.10)
|
1.13.11400.460 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | Adamalysin-II-like mechanism | Glu + zinc ion bound to His cluster | M00029; Leishmanolysin
(Catalytic domains: 3.10.170.20, 3.90.132.10)
S00398; Zinc metalloproteinase atrolysin-D
(Catalytic domain: 3.40.390.10)
S00399; Zinc metalloproteinase adamalysin-2
(Catalytic domain: 3.40.390.10)
|
1.13.11400.1261 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | Adamalysin-II-like mechanism | Glu + two zinc ions bound to His/Asp cluster | D00192; Carboxypeptidase G2 (CPDG2) (EC 3.4.17.11) (Folate hydrolase G2) (Pteroylmonoglutamic acid hydrolase G2) (Glutamate carboxypeptidase)AltName: INN=Glucarpidase;
(Catalytic domain: 3.40.630.10)
S00406; Bacterial leucyl aminopeptidase
(Catalytic domain: 3.40.630.10)
|
1.13.13000.460 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | Matrilysin-like mechanism | Glu + zinc ion bound to His cluster | S00395; Matrilysin
(Catalytic domain: 3.40.390.10)
S00397; Neutrophil collagenase
(Catalytic domain: 3.40.390.10)
|
1.13.30000.9 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | Trypsin-like mechanism | Ser/His/Asp + Asn/Thr/mainchain amide | D00219; Subtilisin Carlsberg
(Catalytic domain: 3.40.50.200)
S00295; Proteinase K
(Catalytic domain: 3.40.50.200)
S00519; Thermitase
(Catalytic domain: 3.40.50.200)
|
1.13.30000.10 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | Trypsin-like mechanism | Ser/His/Asp + mainchain amide | D00189; Carboxypeptidase Y
(Catalytic domain: 3.40.50.1820)
D00194; Chymotrypsin-1
(Catalytic domain: 2.40.10.10)
D00197; Trypsin
(Catalytic domain: 2.40.10.10)
D00211; Brachyurin
(Catalytic domain: 2.40.10.10)
D00212; Glandular kallikrein
(Catalytic domain: 2.40.10.10)
D00214; Elastase-1
(Catalytic domain: 2.40.10.10)
D00216; Leukocyte elastase
(Catalytic domain: 2.40.10.10)
D00224; Streptogrisin-B
(Catalytic domain: 2.40.10.10)
D00426; Cathepsin G
(Catalytic domain: 2.40.10.10)
D00428; Chymase
(Catalytic domain: 2.40.10.10)
D00429; Complement factor D
(Catalytic domain: 2.40.10.10)
D00430; Protease 1
(Catalytic domain: 2.40.10.10)
D00431; Tryptase beta-2
(Catalytic domain: 2.40.10.10)
D00432; Elastase-2A
(Catalytic domain: 2.40.10.10)
D00433; Myeloblastin
(Catalytic domain: 2.40.10.10)
D00434; Streptogrisin-A
(Catalytic domain: 2.40.10.10)
D00435; Glutamyl endopeptidase 2
(Catalytic domain: 2.40.10.10)
D00497; Tonin
(Catalytic domain: 2.40.10.10)
D00528; Epidermal growth factor-binding protein type B
(Catalytic domain: 2.40.10.10)
D00848; Snake venom serine protease Dav-PA
(Catalytic domain: 2.40.10.10)
D00850; Kallikrein-8
(Catalytic domain: 2.40.10.10)
D00851; Glutamyl endopeptidase
(Catalytic domain: 2.40.10.10)
D00852; Granzyme A
(Catalytic domain: 2.40.10.10)
D00855; Granzyme B
(Catalytic domain: 2.40.10.10)
M00122; ATP-dependent Clp protease proteolytic subunit
(Catalytic domain: 3.90.226.10)
M00133; Coagulation factor IX
(Catalytic domain: 2.40.10.10)
M00139; Complement C1r subcomponent
(Catalytic domain: 2.40.10.10)
M00152; Urokinase-type plasminogen activator
(Catalytic domain: 2.40.10.10)
M00155; Tissue-type plasminogen activator (t-plasminogen activator) (t-PA) (tPA) (EC 3.4.21.68)AltName: INN=Alteplase;AltName: INN=Reteplase;
(Catalytic domain: 2.40.10.10)
M00167; Alpha-lytic protease
(Catalytic domain: 2.40.10.10)
M00181; Kallikrein 1-related peptidase b3
(Catalytic domain: 2.40.10.10)
M00212; Vitamin K-dependent protein C
(Catalytic domain: 2.40.10.10)
M00227; Enteropeptidase
(Catalytic domain: 2.40.10.10)
M00315; Mannan-binding lectin serine protease 2
(Catalytic domain: 2.40.10.10)
M00316; Complement C1s subcomponent
(Catalytic domain: 2.40.10.10)
M00317; Complement factor B
(Catalytic domain: 2.40.10.10)
M00348; Suppressor of tumorigenicity 14 protein
(Catalytic domain: 2.40.10.10)
M00349; Serine protease hepsin
(Catalytic domain: 2.40.10.10)
S00353; Proline iminopeptidase
(Catalytic domain: 3.40.50.1820)
S00374; Serine carboxypeptidase 2
(Catalytic domain: 3.40.50.1820)
S00517; Lysosomal protective protein
(Catalytic domain: 3.40.50.1820)
T00074; Prothrombin
(Catalytic domain: 2.40.10.10)
T00410; Acrosin
(Catalytic domain: 2.40.10.10)
T00411; Serine protease HTRA2
(Catalytic domain: 2.40.10.10)
|
1.13.30000.12 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | Trypsin-like mechanism | Ser/Glu/Asp + Asp/mainchain amide | S00296; Pseudomonalisin
(Catalytic domain: 3.40.50.200)
|
1.13.30000.13 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | Trypsin-like mechanism | Ser/Glu/Asp + Tyr/mainchain amide | D00210; Prolyl endopeptidase
(Catalytic domain: 3.40.50.1820)
|
1.13.30000.16 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | Trypsin-like mechanism | Ser/Tyr/Lys + mainchain amide | S00512; Beta-lactamase
(Catalytic domain: 3.40.710.10)
|
1.13.30000.39 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | Trypsin-like mechanism | Cys/His/Glu + Arg/mainchain amide | S00408; Pyrrolidone-carboxylate peptidase
(Catalytic domain: 3.40.630.20)
|
1.13.30000.41 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | Trypsin-like mechanism | Cys/His/Asp + mainchain amide | M00216; Genome polyprotein
(Catalytic domain: 2.40.10.10)
M00217; Genome polyprotein
(Catalytic domain: 2.40.10.10)
|
1.13.30000.42 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | Trypsin-like mechanism | Cys/His/Glu + mainchain amide | M00217; Genome polyprotein
(Catalytic domain: 2.40.10.10)
T00114; GMP synthase {glutamine-hydrolyzing}
(Catalytic domains: 3.40.50.620, 3.40.50.880)
|
1.13.30000.44 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | Trypsin-like mechanism | Cys/His/Asn + Gln/mainchain amide | S00444; Cathepsin Z
(Catalytic domain: 3.90.70.10)
S00445; Cathepsin B
(Catalytic domain: 3.90.70.10)
S00446; Chymopapain
(Catalytic domain: 3.90.70.10)
S00447; Actinidain (Actinidin) (EC 3.4.22.14)AltName: Allergen=Act c 1;
(Catalytic domain: 3.90.70.10)
S00448; Cathepsin H
(Catalytic domain: 3.90.70.10)
S00449; Papaya proteinase 4
(Catalytic domain: 3.90.70.10)
S00450; Caricain
(Catalytic domain: 3.90.70.10)
S00451; Cathepsin K
(Catalytic domain: 3.90.70.10)
S00518; Cathepsin L1
(Catalytic domain: 3.90.70.10)
|
1.13.30000.45 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | Trypsin-like mechanism | Cys/His/Asp + Gln/mainchain amide | S00524; Ubiquitin carboxyl-terminal hydrolase YUH1
(Catalytic domain: 3.40.532.10)
|
1.13.30000.46 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | Trypsin-like mechanism | Cys/His/Tyr + mainchain amide | M00209; Genome polyprotein
(Catalytic domain: 2.40.10.10)
|
1.13.30005.18 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | DmpA-like mechanism | Ser(N-terminal) + N-terminal alpha-amine + Ser/mainchain amide + Asn/mainchain amide | S00528; D-aminopeptidase
(Catalytic domain: 3.60.70.12)
|
1.13.30005.34 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | DmpA-like mechanism | Thr(N-terminal) + N-terminal alpha-amine + Thr + mainchain amide | T00418; Gamma-glutamyltranspeptidase
(Catalytic domain: 3.60.20.10)
|
1.13.30010.35 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | 20S-proteasome-like mechanism | Thr(N-terminal) + N-terminal alpha-amine + Lys/mainchain amide + acidic resiude | M00123; Proteasome component PRE5
(Catalytic domain: 3.60.20.10)
M00174; Proteasome subunit alpha
(Catalytic domain: 3.60.20.10)
|
1.13.30010.30 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | 20S-proteasome-like mechanism | Ser(N-terminal) + N-terminal alpha-amine + Asn/mainchain amide +His | M00309; Glutaryl-7-aminocephalosporanic-acid acylase
(Catalytic domain: 3.60.20.10)
|
1.13.30015.15 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | DD-carboxypeptidase-like mechanism | Ser/Lys/Tyr/Asn/His + mainchain amide | S00414; D-alanyl-D-alanine carboxypeptidase
(Catalytic domain: 3.40.710.10)
T00222; D-aminopeptidase
(Catalytic domain: 3.40.710.10)
|
1.13.30020.28 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | Tricorn protease-like mechanism | Ser/His/Glu/Ser + mainchain amide | M00351; Tricorn protease
(Catalytic domains: 3.30.750.44, 3.90.226.10)
|
1.13.30100.19 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | Caspase-1-like mechanism | Ser/Lys + mainchain amide | D00510; LexA repressor
(Catalytic domain: 2.10.109.10)
|
1.13.30100.40 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | Caspase-1-like mechanism | Cys/His + mainchain amide | D00522; Caspase-1
(Catalytic domain: 3.40.50.1460)
|
1.13.30100.49 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | Caspase-1-like mechanism | Cys/Asp/Lys | S00341; N-carbamoylsarcosine amidase
(Catalytic domain: 3.40.50.850)
|
1.13.30110.56 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | Asparagine-synthetase-B glutamine hydrolysis mechanism | Cys(N-terminal) + N-terminal alpha-amine + Asn/mainchain amide | D00300; Asparagine synthetase B {glutamine-hydrolyzing}
(Catalytic domains: 3.40.50.620, 3.60.20.10)
T00201; Glucosamine--fructose-6-phosphate aminotransferase {isomerizing}
(Catalytic domains: 3.40.50.10490, 3.60.20.10)
|
1.13.30120.22 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | Plasminogen-like mechanism | Ser/His/Asp | M00157; Plasminogen
(Catalytic domain: 2.40.10.10)
|
1.13.30185.55 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | Penicillin acylase-like mechanism | Cys(N-terminal) + N-terminal alpha-amine + Asn/mainchain amide + Arg/Asp | S00437; Penicillin acylase
(Catalytic domain: 3.60.60.10)
|
1.13.29990.17 | Hydrolysis | Amide bond (One of Carbonyl Ester bonds; including peptide bond) | beta-lactamase OXA10 mechanism | Ser/carbamated-Lys + Trp + mainchain amide | S00513; Beta-lactamase OXA-10
(Catalytic domain: 3.40.710.10)
|
1.14.200.137 | Hydrolysis | Thioester (One of Carbonyl Ester bonds) | Pepsin-like mechanism | An acidic residue + [Asn or Gln] + mainchain amide groups + Cys covalently-bound to substrate/intermediate | D00021; Betaine aldehyde dehydrogenase
(Catalytic domains: 3.40.309.10, 3.40.605.10)
|
1.14.800.129 | Hydrolysis | Thioester (One of Carbonyl Ester bonds) | GDP mannose dehydrogenase final step-like mechanism | An acidic residue + Lys/Asp/Thr | T00227; UDP-glucose 6-dehydrogenase
(Catalytic domains: 1.10.1040.10, 3.40.50.720)
T00408; GDP-mannose 6-dehydrogenase
(Catalytic domains: 1.-.-.-, 3.40.50.720)
|
1.14.10105.1251 | Hydrolysis | Thioester (One of Carbonyl Ester bonds) | Glyoxalase-II-like mechanism | Asp + two zinc ions bound to His/Asp cluster | S00431; Hydroxyacylglutathione hydrolase
(Catalytic domain: 3.60.15.10)
|
1.14.30000.10 | Hydrolysis | Thioester (One of Carbonyl Ester bonds) | Trypsin-like mechanism | Ser/His/Asp + mainchain amide | S00350; Palmitoyl-protein thioesterase 1
(Catalytic domain: 3.40.50.1820)
S00919; Thioesterase
(Catalytic domain: 3.40.50.1820)
|
1.14.30000.45 | Hydrolysis | Thioester (One of Carbonyl Ester bonds) | Trypsin-like mechanism | Cys/His/Asp + Gln/mainchain amide | S00524; Ubiquitin carboxyl-terminal hydrolase YUH1
(Catalytic domain: 3.40.532.10)
|
1.14.36110.975 | Hydrolysis | Thioester (One of Carbonyl Ester bonds) | 4-hydroxybenzoyl-CoA thioesterase-like mechanism | Two acidic residues + mainchain amide | S00179; 4-hydroxybenzoyl-CoA thioesterase
(Catalytic domain: 3.10.129.10)
|
1.15.7590.1491 | Hydrolysis | Phosphoric Ester | PP2Calpha phosphtase-like mechanism | His + acidic residue + Arg + two divalent ions bound to three acidic residues/mainchain carbonyl | D00152; Protein phosphatase 1A
(Catalytic domain: 3.60.40.10)
|
1.15.7910.1164 | Hydrolysis | Phosphoric Ester | Inositol-1-monophosphatase-like mechanism | Asp/Thr + mainchain amide groups + two magnesium ions bound to acidic residues/mainchain carbonyl | D00148; 3''(2''),5''-bisphosphate nucleotidase (EC 3.1.3.7) (3''
(Catalytic domains: 3.30.540.10, 3.40.190.80)
D00153; Inositol-1-monophosphatase
(Catalytic domains: 3.30.540.10, 3.40.190.80)
D00491; 3''(2''),5''-bisphosphate nucleotidase 1
(Catalytic domains: 3.30.540.10, 3.40.190.80)
T00053; Inositol polyphosphate 1-phosphatase
(Catalytic domains: 3.30.540.10, 3.40.190.80)
|
1.15.8000.2150 | Hydrolysis | Phosphoric Ester | Inorganic pyrophosphatase-like mechanism | Asp/Arg/Lys/Tyr+ three magnesium ions bound to acidic residues | S00455; Inorganic pyrophosphatase
(Catalytic domain: 3.90.80.10)
|
1.15.8220.1169 | Hydrolysis | Phosphoric Ester | Thermophilus ADPribose pyrophosphatase Ndx4-like mechanism | An acidic residue + Arg/Arg + two magnesium ions bound to acidic residues/mainchain carbonyl | S00922; ADP-ribose pyrophosphatase
(Catalytic domain: 3.90.79.10)
|
1.15.8230.361 | Hydrolysis | Phosphoric Ester | DNA topoisomerase-II ATP hydrolysis mechanism | An acidic residue + Lys + mainchain amide + magnesium ion bound to Asn | M00048; DNA topoisomerase 2
(Catalytic domains: 3.30.230.10, 3.30.565.10, 3.40.50.670, 3.90.199.10)
M00213; DNA gyrase subunit B
(Catalytic domains: 3.30.230.10, 3.30.565.10)
|
1.15.8230.352 | Hydrolysis | Phosphoric Ester | DNA topoisomerase-II ATP hydrolysis mechanism | An acidic residue + Lys cluster + mainchain amide + magnesium ion bound to Ser & water molecules | M00114; Nitrogenase molybdenum-iron protein alpha chain
(Catalytic domains: 3.40.50.300, 3.40.50.1980)
M00199; Nitrogenase molybdenum-iron protein alpha chain
(Catalytic domains: 3.40.50.300, 3.40.50.1980)
|
1.15.8230.362 | Hydrolysis | Phosphoric Ester | DNA topoisomerase-II ATP hydrolysis mechanism | An acidic residue + Arg + [Gln or Asn] + [Ser or Thr] + mainchain amide/carbonyl + magnesium ion bound directly to substrate | T00231; DUTP pyrophosphatase
(Catalytic domain: 2.70.40.10)
|
1.15.8230.371 | Hydrolysis | Phosphoric Ester | DNA topoisomerase-II ATP hydrolysis mechanism | His/Arg + magnesium ion bound to Asn | S00402; Nuclease
(Catalytic domain: 3.40.570.10)
|
1.15.8240.1166 | Hydrolysis | Phosphoric Ester | Nuclease P1-like mechanism | An acidic residue + Lys cluster + two magnesium ions bound to acidic residues/mainchain carbonyl + another magnesium ion bound to leaving group | S00815; Bis(5''-nucleosyl)-tetraphosphatase {asymmetrical}
(Catalytic domain: 3.90.79.10)
|
1.15.8240.1167 | Hydrolysis | Phosphoric Ester | Nuclease P1-like mechanism | An acidic residue + Arg/Lys + two magnesium ions bound to acidic residues/mainchain carbonyl + another magnesium ion bound to leaving group | S00920; Diadenosine 5'',5''''''-P1,P4-tetraphosphate hydrolase
(Catalytic domain: 3.90.79.10)
|
1.15.8240.2170 | Hydrolysis | Phosphoric Ester | Nuclease P1-like mechanism | Asp/Arg + two zinc ions bound to His/Asp cluster & mainchain (interacting throuhg a water) + zinc ion bound to His/Asp cluster | S00022; Nuclease P1
(Catalytic domain: 1.10.575.10)
|
1.15.8245.1168 | Hydrolysis | Phosphoric Ester | E.coli ADPribose pyrophosphatase-like mechanism | An acidic residue + Arg + three magnesium ions bound to acidic residues/mainchain carbonyl | S00814; ADP-ribose pyrophosphatase
(Catalytic domain: 3.90.79.10)
S00921; Putative uncharacterized protein
(Catalytic domain: 3.90.79.10)
S00923; MutT/nudix family protein
(Catalytic domain: 3.90.79.10)
S00924; ADP-sugar pyrophosphatase
(Catalytic domain: 3.90.79.10)
|
1.15.8300.1170 | Hydrolysis | Phosphoric Ester | BamHI-like mechanism | Glu + two magnesium ions bound to acidic residues | S00384; Type-2 restriction enzyme BamHI
(Catalytic domain: 3.40.91.20)
|
1.15.8310.1250 | Hydrolysis | Phosphoric Ester | Phosphotriesterase-like mechanism | An acidic residue + two zinc ions bound to carbamated Lys & His/Asp cluster | S00231; Parathion hydrolase
(Catalytic domain: 3.20.20.140)
|
1.15.9400.1180 | Hydrolysis | Phosphoric Ester | Type-II restriction enzyme-like mechanism | Lys + two magnesium ions bound to acidic residues | S00383; Type-2 restriction enzyme Cfr10I
(Catalytic domain: 3.40.91.10)
S00390; Type-2 restriction enzyme PvuII
(Catalytic domain: 3.40.210.10)
S00403; Type-2 restriction enzyme EcoRI
(Catalytic domain: 3.40.580.10)
S00404; Type-2 restriction enzyme EcoRV
(Catalytic domain: 3.40.600.10)
S00405; Type-2 restriction enzyme BglI
(Catalytic domain: 3.40.600.20)
S00462; Exonuclease
(Catalytic domain: 3.90.320.10)
T00055; Type-2 restriction enzyme FokI
(Catalytic domain: 3.40.91.30)
|
1.15.9500.580 | Hydrolysis | Phosphoric Ester | Iron(III)-zinc(II) purple acid phosphatase-like mechanism | His/His + Fe(III)/Zinc2+ bound to Asp/His cluster | D00146; Fe(3+)-Zn(2+) purple acid phosphatase (PAP) (EC 3.1.3.2) (Iron
(Catalytic domain: 3.60.21.10)
|
1.15.9500.540 | Hydrolysis | Phosphoric Ester | Iron(III)-zinc(II) purple acid phosphatase-like mechanism | Asp/His + Fe(III)/Fe(II) bound to Asp/His cluster | S00435; Tartrate-resistant acid phosphatase type 5
(Catalytic domain: 3.60.21.10)
|
1.15.9995.1169 | Hydrolysis | Phosphoric Ester | Human ADPribose pyrophosphatase NUDT9-like mechanism | An acidic residue + Arg/Arg + two magnesium ions bound to an acidic residue/mainchain carbonyl | D00880; ADP-ribose pyrophosphatase
(Catalytic domain: 3.90.79.10)
|
1.15.10100.1172 | Hydrolysis | Phosphoric Ester | DNA-topoisomerase-I/3'-5' exonuclease-like mechanism | Glu/Tyr + two divalent metal ions bound to acidic residues | M00055; DNA polymerase I
(Catalytic domains: 1.10.473.10, 3.30.70.370, 3.30.420.10)
|
1.15.11200.472 | Hydrolysis | Phosphoric Ester | Deoxyribonuclease-1-like mechanism | His/His + divalent metal bound to Asp/Glu cluster | S00429; Deoxyribonuclease-1
(Catalytic domain: 3.60.10.10)
|
1.15.14410.1770 | Hydrolysis | Phosphoric Ester | Serine/threonine protein phosphatase 2B-like mechanism | His/Asp/Arg + Fe(III)/Zinc bound to Asp/His cluster | D00151; Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
(Catalytic domain: 3.60.21.10)
|
1.15.30200.84 | Hydrolysis | Phosphoric Ester | Prostatic acid phosphatase-like mechanism | His/Asp + Arg/His cluster | D00514; Periplasmic appA protein
(Catalytic domain: 3.40.50.1240)
S00363; Prostatic acid phosphatase
(Catalytic domain: 3.40.50.1240)
|
1.15.30200.81 | Hydrolysis | Phosphoric Ester | Prostatic acid phosphatase-like mechanism | His/His/Glu + Arg/Asn cluster | S00365; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
(Catalytic domain: 3.40.50.1240)
|
1.15.32000.86 | Hydrolysis | Phosphoric Ester | 3-phytase-like mechanism | His/Asp | D00460; 3-phytase A
(Catalytic domain: 3.40.50.1240)
|
1.15.33000.50 | Hydrolysis | Phosphoric Ester | Adipocyte acid phosphatase-like mechanism | Cys/Asp/Arg | S00298; Low molecular weight phosphotyrosine protein phosphatase
(Catalytic domain: 3.40.50.270)
|
1.15.36030.52 | Hydrolysis | Phosphoric Ester | Tyrosine-protein-phosphatase-like mechanism | Cys/Asp/Arg + mainchain amide group + Ser or Thr | D00154; Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
(Catalytic domain: 3.90.190.10)
M00149; Receptor-type tyrosine-protein phosphatase F
(Catalytic domain: 3.90.190.10)
M00169; Tyrosine-protein phosphatase non-receptor type 13
(Catalytic domain: 3.90.190.10)
S00458; Dual specificity protein phosphatase 3
(Catalytic domain: 3.90.190.10)
T00221; Tyrosine-protein phosphatase non-receptor type 11
(Catalytic domain: 3.90.190.10)
|
1.15.36100.51 | Hydrolysis | Phosphoric Ester | M-phase-inducer-phosphatase-1-like mechanism | Cys/Glu/Arg | S00393; M-phase inducer phosphatase 1
(Catalytic domain: 3.40.250.10)
|
1.15.39000.353 | Hydrolysis | Phosphoric Ester | SER Ca(2+)-ATPase-1-like mechanism | Asp + magnesium ion bound to Asp cluster | M00102; Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
(Catalytic domain: 3.40.50.1000)
|
1.15.60000.82 | Hydrolysis | Phosphoric Ester | Ribonuclease-U2-like mechanism | His/His + Acidic residue | S00467; Ribonuclease Rh
(Catalytic domain: 3.90.730.10)
|
1.15.60000.85 | Hydrolysis | Phosphoric Ester | Ribonuclease-U2-like mechanism | His/Glu/Arg | S00174; Ribonuclease U2
(Catalytic domain: 3.10.450.30)
S00175; Ribonuclease alpha-sarcin
(Catalytic domain: 3.10.450.30)
|
1.15.72000.565 | Hydrolysis | Phosphoric Ester | Phosphoinositide phospholipase-C-delta-1-like mechanism | Glu/His + His/Glu/Asn + calcium ion bound to His/Asn + acidic residues | M00118; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1
(Catalytic domain: 3.20.20.190)
M00183; Putative uncharacterized protein
(Catalytic domain: 3.20.20.190)
|
1.19.30000.41 | Hydrolysis | Carboxylic Ester bond with conjugated double bond | Trypsin-like mechanism | Cys/His/Asp + mainchain amide | S00348; Carboxymethylenebutenolidase
(Catalytic domain: 3.40.50.1820)
|
1.19.30000.10 | Hydrolysis | Carboxylic Ester bond with conjugated double bond | Trypsin-like mechanism | Ser/His/Asp + mainchain amide | D00144; Chemotaxis response regulator protein-glutamate methylesterase
(Catalytic domain: 3.40.50.180)
|
1.20.30800.980 | Hydrolysis | Halide bond | L-2-haloacid dehalogenase-like mechanism | Two acidic residues + Arg/Asn/Thr/Ser + Lys/Tyr | D00248; (S)-2-haloacid dehalogenase
(Catalytic domains: 1.10.164.10, 3.40.50.1000)
|
1.20.30810.950 | Hydrolysis | Halide bond | Halogenase-like mechanism | Asp/His/Asp + mainchain amide + Trp/Trp | S00356; Haloalkane dehalogenase
(Catalytic domain: 3.40.50.1820)
|
1.20.30810.951 | Hydrolysis | Halide bond | Halogenase-like mechanism | Asp/His/Glu + mainchain amide + Trp/Asn | S00525; Haloalkane dehalogenase
(Catalytic domain: 3.40.50.1820)
|
1.30.260.1001 | Hydrolysis | C-O bond (O-glycoside bond) | Endo-polygalacturonase-like mechanism | Four acidic residues + Lys/Arg | S00168; Endo-polygalacturonase
(Catalytic domain: 2.160.20.10)
|
1.30.300.2 | Hydrolysis | C-O bond (O-glycoside bond) | Exoglucanase-II-like mechanism | Two acidic residues | D00536; Endoglucanase E-2
(Catalytic domain: 3.20.20.40)
D00537; Exoglucanase 2
(Catalytic domain: 3.20.20.40)
S00021; Lysozyme
(Catalytic domain: 1.10.530.40)
S00194; Endoglucanase-6B
(Catalytic domain: 3.20.20.40)
S00265; Chitosanase
(Catalytic domain: 1.10.530.40)
|
1.30.4920.981 | Hydrolysis | C-O bond (O-glycoside bond) | Glucoamylase-like mechanism | Two acidic residues + Arg/Tyr | D00500; Glucoamylase
(Catalytic domain: 1.50.10.10)
|
1.30.4950.1 | Hydrolysis | C-O bond (O-glycoside bond) | Goose-lysozyme-like mechanism | An acidic residue | S00520; Lysozyme g
(Catalytic domain: 1.10.530.10)
|
1.30.5050.991 | Hydrolysis | C-O bond (O-glycoside bond) | Cellulase9A-like mechanism | Three acidic residues + Tyr/His | D00167; Cellulase Cel9-M
(Catalytic domain: 1.50.10.10)
M00192; Endoglucanase E-4
(Catalytic domain: 1.50.10.10)
S00531; Endo-b-1,4-glucanase (Cellulase NtEG)
(Catalytic domain: 1.50.10.10)
T00246; Endoglucanase G
(Catalytic domain: 1.50.10.10)
|
1.30.5050.993 | Hydrolysis | C-O bond (O-glycoside bond) | Cellulase9A-like mechanism | Three acidic residues + Tyr/Tyr | T00245; Endoglucanase D
(Catalytic domain: 1.50.10.10)
|
1.30.5100.2 | Hydrolysis | C-O bond (O-glycoside bond) | beta-amylase-like mechanism | Two acidic residues | D00166; Beta-amylase
(Catalytic domain: 3.20.20.80)
S00125; Endoglucanase-5
(Catalytic domain: 2.40.40.10)
|
1.30.11370.560 | Hydrolysis | C-O bond (O-glycoside bond) | ER-Man(9)-alpha-mannosidase-like mechanism | Two acidic residues + calcium ion bound to Thr | D00470; Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
(Catalytic domain: 1.50.10.50)
S00051; Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
(Catalytic domain: 1.50.10.50)
|
1.30.33100.2 | Hydrolysis | C-O bond (O-glycoside bond) | Lysozyme-C-like mechanism | Two acidic residues | S00509; Lysozyme C (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase C) (Allergen Gal d IV)AltName: Allergen=Gal d 4;
(Catalytic domain: 1.10.530.10)
|
1.30.35880.983 | Hydrolysis | C-O bond (O-glycoside bond) | beta-galactanase-like mechanism | Two acidic residues + Arg/Tyr + Asn or Gln | S00748; Arabinogalactan endo-1,4-beta-galactosidase
(Catalytic domain: 3.20.20.80)
S00912; YvfO
(Catalytic domain: 3.20.20.80)
|
1.30.35885.972 | Hydrolysis | C-O bond (O-glycoside bond) | beta-xylosidase-like mechanism | Two acidic residues + Arg/His/Tyr + Asn or Gln | D00501; Endoglucanase Z
(Catalytic domain: 3.20.20.80)
D00502; Endoglucanase E1
(Catalytic domain: 3.20.20.80)
D00503; Endoglucanase A
(Catalytic domain: 3.20.20.80)
D00844; Beta-xylosidase
(Catalytic domain: 3.20.20.80)
D00861; Mannanase
(Catalytic domain: 3.20.20.80)
D00864; Glucosylceramidase
(Catalytic domain: 3.20.20.80)
S00203; Endoglucanase C
(Catalytic domain: 3.20.20.80)
S00208; Glucan 1,3-beta-glucosidase
(Catalytic domain: 3.20.20.80)
S00210; Mannan endo-1,4-beta-mannosidase 4
(Catalytic domain: 3.20.20.80)
S00906; Beta-mannanase
(Catalytic domain: 3.20.20.80)
S00907; Mannan endo-1,4-beta-mannosidase
(Catalytic domain: 3.20.20.80)
|
1.30.35890.994 | Hydrolysis | C-O bond (O-glycoside bond) | alpha-N-acetylgalactosaminidase-like mechanism | Three acidic residues + Arg/Tyr | D00664; Alpha-galactosidase
(Catalytic domain: 3.20.20.70)
D00665; Alpha-N-acetylgalactosaminidase
(Catalytic domain: 3.20.20.70)
D00863; Alpha-galactosidase
(Catalytic domain: 3.20.20.70)
|
1.30.36000.3 | Hydrolysis | C-O bond (O-glycoside bond) | alpha-amylase-like mechanism | Three acidic residues | D00165; Alpha-amylase type B isozyme
(Catalytic domain: 3.20.20.80)
D00176; Glucan 1,4-alpha-maltotetraohydrolase
(Catalytic domain: 3.20.20.80)
M00112; Maltogenic alpha-amylase
(Catalytic domain: 3.20.20.80)
M00193; Neopullulanase 2
(Catalytic domain: 3.20.20.80)
T00057; Alpha-amylase
(Catalytic domain: 3.20.20.80)
T00062; Oligo-1,6-glucosidase
(Catalytic domain: 3.20.20.80)
T00067; Isoamylase
(Catalytic domain: 3.20.20.80)
|
1.30.36010.970 | Hydrolysis | C-O bond (O-glycoside bond) | Exoglucanase/xylanase-A-like mechanism | Two acidic residues + His/Asp | D00169; Endo-1,4-beta-xylanase A
(Catalytic domain: 3.20.20.80)
D00479; Exoglucanase/xylanase
(Catalytic domain: 3.20.20.80)
M00160; Endo-1,4-beta-xylanase A
(Catalytic domain: 3.20.20.80)
|
1.30.36020.973 | Hydrolysis | C-O bond (O-glycoside bond) | Gentiobiase-like mechanism | Two acidic residues + His/Tyr | S00205; Beta-glucosidase A
(Catalytic domain: 3.20.20.80)
|
1.30.36040.982 | Hydrolysis | C-O bond (O-glycoside bond) | beta-D-glucan-exohydrolase-like mechanism | Two acidic residues + Trp/Trp/Arg | D00175; Beta-D-glucan exohydrolase isoenzyme ExoI
(Catalytic domains: 3.20.20.300, 3.40.50.1700)
|
1.30.36200.973 | Hydrolysis | C-O bond (O-glycoside bond) | Lactase-like mechanism | Two acidic residues + His/Tyr | S00206; Beta-galactosidase
(Catalytic domain: 3.20.20.80)
|
1.30.36027.984 | Hydrolysis | C-O bond (O-glycoside bond) | beta-mannanase26-like mechanism | Two acidic residues + Trp/Arg/Tyr/His/Trp | M00346; Man26A
(Catalytic domain: 3.20.20.80)
S00911; Beta-1,4-mannanase
(Catalytic domain: 3.20.20.80)
S00915; Endo-1
(Catalytic domain: 3.20.20.80)
|
1.30.36210.971 | Hydrolysis | C-O bond (O-glycoside bond) | Sialidase-like mechanism | Two acidic residues + Tyr | S00207; Glucan endo-1,3-beta-glucosidase GII
(Catalytic domain: 3.20.20.80)
S00209; Lichenase-2
(Catalytic domain: 3.20.20.80)
S00211; 6-phospho-beta-galactosidase
(Catalytic domain: 3.20.20.80)
T00066; Beta-glucuronidase
(Catalytic domain: 3.20.20.80)
|
1.30.36210.990 | Hydrolysis | C-O bond (O-glycoside bond) | Sialidase-like mechanism | Three acidic residues + His | S00162; Endoglucanase 1
(Catalytic domain: 2.70.100.10)
|
1.30.36211.974 | Hydrolysis | C-O bond (O-glycoside bond) | Endoglucanase-E1-like mechanism | Two acidic residues + Tyr/Tyr | D00538; Endo-1,4-beta-xylanase
(Catalytic domain: 2.60.120.180)
S00151; Endo-1,4-beta-xylanase
(Catalytic domain: 2.60.120.180)
|
1.30.36211.992 | Hydrolysis | C-O bond (O-glycoside bond) | Endoglucanase-E1-like mechanism | Three acidic residues + Asn or Gln | D00504; Cellulase B
(Catalytic domain: 2.60.120.180)
S00150; Cellulase
(Catalytic domain: 2.60.120.180)
|
1.30.36211.1000 | Hydrolysis | C-O bond (O-glycoside bond) | Endoglucanase-E1-like mechanism | Four acidic residues | S00533; Endoglucanase A
(Catalytic domain: 2.60.120.180)
|
1.30.36300.2 | Hydrolysis | C-O bond (O-glycoside bond) | Endo-beta-(1->3)-(1->4) glucanase-like mechanism | Two acidic residues | S00511; Beta-glucanase
(Catalytic domain: 2.60.120.200)
|
1.30.46030.482 | Hydrolysis | C-O bond (O-glycoside bond) | alpha-mannosidase-like mechanism | Two acidic residues + Arg/Tyr + zinc ion bound to His/acidic residue + substrate/intermediate | M00314; Alpha-mannosidase
(Catalytic domains: 1.-.-.-, 3.20.110.10)
|
1.31.36210.99 | Hydrolysis | C-O bond (O-glycoside bond) adjacent to carboxylate | Sialidase-like mechanism | Tyr + two acidic residues | T00065; Sialidase
(Catalytic domain: 2.120.10.10)
T00208; Sialidase
(Catalytic domain: 2.120.10.10)
|
1.32.5000.73 | Hydrolysis | C-O bond (O-glycoside bond) close to N-acetyl group | Chitinase-A-like mechanism | Glu/Tyr/Asp | M00134; Chitinase A1
(Catalytic domain: 3.20.20.80)
T00063; Chitinase A
(Catalytic domain: 3.20.20.80)
|
1.32.60200.73 | Hydrolysis | C-O bond (O-glycoside bond) close to N-acetyl group | Hevamine-A-like mechanism | Glu/Tyr/Asp | S00204; Hevamine-A
(Catalytic domain: 3.20.20.80)
S00213; Endo-beta-N-acetylglucosaminidase H
(Catalytic domain: 3.20.20.80)
|
1.32.68200.2 | Hydrolysis | C-O bond (O-glycoside bond) close to N-acetyl group | Chitobiase-like mechanism | Two acidic residues | M00026; Chitobiase
(Catalytic domain: 3.20.20.80)
|
1.32.68230.73 | Hydrolysis | C-O bond (O-glycoside bond) close to N-acetyl group | Hyaluronidase-like mechanism | Glu/Tyr/Asp | D00804; Hyaluronidase-1
(Catalytic domain: 3.20.20.70)
S00745; Hyaluronidase A (Hya A) (EC 3.2.1.35) (Hyaluronoglucosaminidase A) (Allergen Ves v II)AltName: Allergen=Ves v 2a;
(Catalytic domain: 3.20.20.70)
|
1.35.30000.63 | Hydrolysis | C-O bond (epoxide; cyclic ether) | Trypsin-like mechanism | Asp/His/Asp/Tyr + mainchain amide | D00539; Epoxide hydrolase 2
(Catalytic domain: 3.40.50.1820)
S00352; Epoxide hydrolase
(Catalytic domain: 3.40.50.1820)
|
1.40.300.2 | Hydrolysis | C-N bond (N-glycoside bond) | Exoglucanase-II-like mechanism | Two acidic residues | S00188; DNA-3-methyladenine glycosylase
(Catalytic domain: 3.10.300.10)
|
1.40.4930.61 | Hydrolysis | C-N bond (N-glycoside bond) | Uracil-DNA glycosylase-like mechanism | Asp/His | S00401; Uracil-DNA glycosylase
(Catalytic domain: 3.40.470.10)
|
1.40.6430.132 | Hydrolysis | C-N bond (N-glycoside bond) | AlkA-DNA-glycosylase-like mechanism | An acidic residue + Tyr/Trp | T00070; DNA-3-methyladenine glycosylase 2
(Catalytic domains: 1.10.340.30, 1.10.1670.10)
|
1.40.7050.132 | Hydrolysis | C-N bond (N-glycoside bond) | TAG-DNA-glycosylase-like mechanism | An acidic residue + Tyr/Trp | S00749; DNA-3-methyladenine glycosylase 1
(Catalytic domain: 1.10.340.30)
|
1.40.14550.574 | Hydrolysis | C-N bond (N-glycoside bond) | IU-nucleoside hydrolase-like mechanism | His/Asp + calcium ion bound to acidic residues | S00461; Inosine-uridine preferring nucleoside hydrolase
(Catalytic domain: 3.90.245.10)
S00751; Pyrimidine-specific ribonucleoside hydrolase rihB
(Catalytic domain: 3.90.245.10)
|
1.51.3100.78 | Hydrolysis | C-C bond (Ketonic Carbon-Carbon bond; Carbonyl Carbon-Carbon adjacent to sp2 carbon) | C-C hydrolase-like hydrolysis mechanism | His/Ser/Asp | S00355; 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase
(Catalytic domain: 3.40.50.1820)
S00526; 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase
(Catalytic domain: 3.40.50.1820)
|
1.51.790.101 | Hydrolysis | C-C bond (Ketonic Carbon-Carbon bond; Carbonyl Carbon-Carbon adjacent to sp2 carbon) | Beta-ketoacyl-ACP synthase II 2nd reaction step-like mechanism | His/His/Lys | D00871; 3-oxoacyl-[acyl-carrier-protein] synthase 2
(Catalytic domain: 3.40.47.10)
|
1.60.55100.9000 | Hydrolysis | C-S bond (S-glycoside bond) | Myrosinase-MA1-like mechanism | Glu/Tyr + Ascorbate bound to Gln | S00214; Myrosinase MA1
(Catalytic domain: 3.20.20.80)
|
2.15.32480.334 | Phosphorolysis | Phosphoric Ester | Stabilizer; SN2-like nucleophilic attack on covalent bond by phosphate; Cofactor-assisted stabilization of SN2-like transition state mechanism | Arg/Lys cluster + mainchain amide + magnesium ion bound to acidic residues | S00465; Glucose-1-phosphate thymidylyltransferase 1
(Catalytic domain: 3.90.550.10)
|
2.40.18000.65 | Phosphorolysis | C-N bond (N-glycoside bond) | Acid/Stabilizer; SN1-like transition state; nucleophilic attack by phosphate group; Protonation to leaving group by acid mechanism | Asp + negatively charged residues | S00376; S-methyl-5''-thioadenosine phosphorylase
(Catalytic domain: 3.40.50.1580)
S00510; Purine nucleoside phosphorylase deoD-type
(Catalytic domain: 3.40.50.1580)
|
2.40.18500.20 | Phosphorolysis | C-N bond (N-glycoside bond) | Stabilizer; SN1-like transition state; nucleophilic attack by phosphate group mechanism | Asn/[Glu or Asp] + negatively charged residues | S00375; Purine nucleoside phosphorylase
(Catalytic domain: 3.40.50.1580)
|
2.40.48000.390 | Phosphorolysis | C-N bond (N-glycoside bond) | Stabilizer; SN1-like transition state; nucleophilic attack by phosphate group; cofactor-assisted mechanism | Lys/Arg + magnesium ion bound | S00288; Orotate phosphoribosyltransferase
(Catalytic domain: 3.40.50.2020)
|
3.100.790.76 | Transfer | Phosphate group from Hydroxyl oxygen to Hydroxyl oxygen | Bacterial PI-PLC-like mechanism | His/His + acidic residues + Arg | S00236; 1-phosphatidylinositol phosphodiesterase
(Catalytic domain: 3.20.20.190)
|
3.100.219000.96 | Transfer | Phosphate group from Hydroxyl oxygen to Hydroxyl oxygen | DNA topoisomerase III autotransfer mechanism | Tyr/Glu + Arg/Lys cluster | M00158; DNA topoisomerase 3
(Catalytic domains: 1.10.290.10, 3.40.50.140)
|
3.100.219010.98 | Transfer | Phosphate group from Hydroxyl oxygen to Hydroxyl oxygen | DNA topoisomerase I autotransfer mechanism | Tyr/Glu/His/Asp + Arg/Lys cluster | M00034; DNA topoisomerase 1
(Catalytic domains: 1.10.290.10, 3.40.50.140)
|
3.100.220195.81 | Transfer | Phosphate group from Hydroxyl oxygen to Hydroxyl oxygen | Cofactor-dependent-phosphoglycerate-mutase-like mechanism | His/His/Glu + Arg/Asn cluster | S00366; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
(Catalytic domain: 3.40.50.1240)
|
3.100.305000.501 | Transfer | Phosphate group from Hydroxyl oxygen to Hydroxyl oxygen | DNA topoisomerase II autotransfer mechanism | Tyr + Acidic residues + Arg cluster + magnesium ion bound to acidic residues | M00048; DNA topoisomerase 2
(Catalytic domains: 3.30.230.10, 3.30.565.10, 3.40.50.670, 3.90.199.10)
|
3.103.69900.359 | Transfer | Phosphate group from Phosphate oxygen to Hydroxyl oxygen | 6-phosphofructokinase-like mechanism | Asp/Asp + Arg/Thr + mainchain amide + magnesium ion bound to acidic residues | D00111; 6-phosphofructokinase
(Catalytic domains: 3.40.50.450, 3.40.50.460)
|
3.103.69910.364 | Transfer | Phosphate group from Phosphate oxygen to Hydroxyl oxygen | Deoxycytidine kinase-like mechanism | An acidic residue + Arg/Lys cluster + mainchain amide groups + magnesium ion bound to acidic residue and [Ser or Thr] | S00672; Deoxynucleoside kinase
(Catalytic domain: 3.40.50.300)
S00682; Deoxycytidine kinase
(Catalytic domain: 3.40.50.300)
|
3.103.70000.350 | Transfer | Phosphate group from Phosphate oxygen to Hydroxyl oxygen | Thymidine kinase-like mechanism | An acidic residue + Arg/Lys cluster + magnesium ion bound to acidic residue and [Ser or Thr] | S00302; Thymidine kinase
(Catalytic domain: 3.40.50.300)
|
3.103.70000.357 | Transfer | Phosphate group from Phosphate oxygen to Hydroxyl oxygen | Thymidine kinase-like mechanism | Asp/Arg + mainchain amide + magnesium ion bound | D00416; Adenosine kinase
(Catalytic domains: 3.30.1110.10, 3.40.1190.20)
|
3.103.70020.355 | Transfer | Phosphate group from Phosphate oxygen to Hydroxyl oxygen | N-acylneuraminate cytidylyltransferase-like mechanism | An acidic residue + Arg/Lys cluster + magnesium ion bound to acidic residues | S00466; N-acylneuraminate cytidylyltransferase
(Catalytic domain: 3.90.550.10)
|
3.103.70035.351 | Transfer | Phosphate group from Phosphate oxygen to Hydroxyl oxygen | Shikimate kinase-II-like mechanism | An acidic residue + Lys cluster + mainchain amide groups + magnesium ion bound to Asp/Ser | D00116; Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
(Catalytic domains: 3.30.800.10, 3.30.810.10)
|
3.103.70035.355 | Transfer | Phosphate group from Phosphate oxygen to Hydroxyl oxygen | Shikimate kinase-II-like mechanism | An acidic residue + Arg/Lys cluster + magnesium ion bound to acidic residues | S00301; Phosphoribulokinase 1
(Catalytic domain: 3.40.50.300)
|
3.103.70035.360 | Transfer | Phosphate group from Phosphate oxygen to Hydroxyl oxygen | Shikimate kinase-II-like mechanism | An acidic residue + Arg/Lys cluster + mainchain amide groups + magnesium ion bound to [Ser or Thr] | S00304; Shikimate kinase 2
(Catalytic domain: 3.40.50.300)
S00554; Shikimate kinase 1
(Catalytic domain: 3.40.50.300)
S00555; Shikimate kinase
(Catalytic domain: 3.40.50.300)
S00680; Uridine-cytidine kinase 2
(Catalytic domain: 3.40.50.300)
|
3.103.70035.364 | Transfer | Phosphate group from Phosphate oxygen to Hydroxyl oxygen | Shikimate kinase-II-like mechanism | An acidic residue + Arg/Lys cluster + mainchain amide groups + magnesium ion bound to acidic residue and [Ser or Thr] | S00676; Dephospho-CoA kinase
(Catalytic domain: 3.40.50.300)
S00913; Dephospho-CoA kinase
(Catalytic domain: 3.40.50.300)
|
3.103.70035.366 | Transfer | Phosphate group from Phosphate oxygen to Hydroxyl oxygen | Shikimate kinase-II-like mechanism | An acidic residue + Lys (cluster) + mainchain amide groups + magnesium ion bound to [Asn or Gln] and [Ser or Thr] | S00914; Dephospho-CoA kinase
(Catalytic domain: 3.40.50.300)
|
3.103.70035.456 | Transfer | Phosphate group from Phosphate oxygen to Hydroxyl oxygen | Shikimate kinase-II-like mechanism | An acidic residue + mainchain amide groups + zinc ion bound + potassium ion bound to acidic residues/Ser or Thr/mainchain carbonyl | S00678; Pyridoxal kinase
(Catalytic domain: 3.40.1190.20)
|
3.103.70200.1160 | Transfer | Phosphate group from Phosphate oxygen to Hydroxyl oxygen | Poly(A) polymerase-alpha-like mechanism | An acidic residue + two magnesium ions bound to acidic residues | M00218; Poly(A) polymerase alpha
(Catalytic domain: 3.30.460.10)
T00202; Poly(A) polymerase
(Catalytic domain: 3.30.460.10)
|
3.103.70800.502 | Transfer | Phosphate group from Phosphate oxygen to Hydroxyl oxygen | Adenylyl-sulfate kinase-like mechanism | Tyr/Ser + Lys cluster + magnesium ion bound to acidic residue/Ser or Thr | S00303; Adenylyl-sulfate kinase
(Catalytic domain: 3.40.50.300)
|
3.103.70810.363 | Transfer | Phosphate group from Phosphate oxygen to Hydroxyl oxygen | Glucokinase-like mechanism | An acidic residue + Arg + magnesium ion bound to substrate/water | D00643; Glucokinase
(Catalytic domain: 3.40.367.20)
|
3.103.75410.402 | Transfer | Phosphate group from Phosphate oxygen to Hydroxyl oxygen | Gluconate kinase-like mechanism | Lys/Arg + mainchain amide groups + magnesium ion bound to Ser & acidic residues through water | S00671; Thermoresistant gluconokinase
(Catalytic domain: 3.40.50.300)
|
3.103.78000.1130 | Transfer | Phosphate group from Phosphate oxygen to Hydroxyl oxygen | HPP kinase-like mechanism | Arg cluster + two magnesium ions bound to acidic residues | S00258; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
(Catalytic domain: 3.30.70.560)
|
3.103.78010.320 | Transfer | Phosphate group from Phosphate oxygen to Hydroxyl oxygen | Hydroxyethylthiazole-kinase-like mechanism | mainchain amide + magnesium ion bound to acidic residues | S00453; Hydroxyethylthiazole kinase
(Catalytic domain: 3.40.1190.20)
|
3.103.78020.387 | Transfer | Phosphate group from Phosphate oxygen to Hydroxyl oxygen | Pyridoxal kinase-like mechanism | Lys + mainchain amide groups + magnesium bound to acidic residues and mainchain carbonyl | S00905; Phosphomethylpyrimidine kinase
(Catalytic domain: 3.40.1190.20)
|
3.103.80570.321 | Transfer | Phosphate group from Phosphate oxygen to Hydroxyl oxygen | HMP kinase 1st reaction step-like mechanism | mainchain amide groups + magnesium ion bound to Thr | S00705; Phosphomethylpyrimidine kinase
(Catalytic domain: 3.40.1190.20)
|
3.103.90000.335 | Transfer | Phosphate group from Phosphate oxygen to Hydroxyl oxygen | Gro-PCT-like mechanism | Arg/His/Gln cluster + mainchain amide + magnesium ion bound | D00302; RNA 3''-terminal phosphate cyclase
(Catalytic domain: 3.65.10.20)
|
3.103.90020.1131 | Transfer | Phosphate group from Phosphate oxygen to Hydroxyl oxygen | DNA polymerase-like mechanism | Arg/Lys/Asn + two magnesium ions bound to acidic residues | M00019; DNA polymerase
(Catalytic domains: 1.10.287.280, 3.30.70.270)
|
3.103.90020.1134 | Transfer | Phosphate group from Phosphate oxygen to Hydroxyl oxygen | DNA polymerase-like mechanism | Arg/Lys/Asn + two magnesium ions bound to acidic residues/Ser/mainchain carbonyl | M00020; DNA polymerase
(Catalytic domains: 1.-.-.-, 3.90.-.-)
|
3.103.90020.1135 | Transfer | Phosphate group from Phosphate oxygen to Hydroxyl oxygen | DNA polymerase-like mechanism | Arg/Lys/His/Tyr + two magnesium ions bound to acidic residues/mainchain carbonyl | M00173; DNA polymerase
(Catalytic domains: 1.10.150.20, 3.30.70.370)
|
3.103.90020.1136 | Transfer | Phosphate group from Phosphate oxygen to Hydroxyl oxygen | DNA polymerase-like mechanism | Arg/Lys + two magnesium ions bound to acidic residues/mainchain carbonyl | M00104; DNA-directed RNA polymerase
(Catalytic domains: 1.10.150.20, 3.30.70.370)
M00200; Adenylate cyclase type 5
(Catalytic domain: 3.30.70.1230)
|
3.103.90020.1140 | Transfer | Phosphate group from Phosphate oxygen to Hydroxyl oxygen | DNA polymerase-like mechanism | Arg/Lys + mainchain amide + magnesium ion bound to Thr + a divalent metal ion bound to His/Asp/Lys | T00084; Phosphoenolpyruvate carboxykinase {ATP}
(Catalytic domains: 2.170.8.10, 3.40.449.10, 3.90.228.20)
|
3.103.90020.1141 | Transfer | Phosphate group from Phosphate oxygen to Hydroxyl oxygen | DNA polymerase-like mechanism | Arg/Lys/His + mainchain amide groups + two divalent metal ions bound to acidic residues/mainchain carbonyl | M00055; DNA polymerase I
(Catalytic domains: 1.10.473.10, 3.30.70.370, 3.30.420.10)
M00175; DNA polymerase I
(Catalytic domains: 1.10.473.10, 3.30.70.370, 3.40.50.1010)
|
3.103.90021.1120 | Transfer | Phosphate group from Phosphate oxygen to Hydroxyl oxygen | Reverse transcriptase-like mechanism | mainchain amide groups + two magnesium ions bound to acidic residues | M00135; Gag-Pol polyprotein
(Catalytic domains: 3.30.70.270, 3.30.420.10)
M00166; Gag-Pol polyprotein
(Catalytic domains: 2.40.70.10, 3.30.70.270, 3.30.420.10)
|
3.103.106000.1163 | Transfer | Phosphate group from Phosphate oxygen to Hydroxyl oxygen | PI3-kinase-p110-like mechanism | Asp/His + Ser/Lys + two magnesium ions bound to Asp/Asn | M00043; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Catalytic domains: 1.10.1070.11, 3.30.1010.10)
|
3.103.126600.1165 | Transfer | Phosphate group from Phosphate oxygen to Hydroxyl oxygen | Phosphorylase-kinase-like mechanism | Asp + Lys cluster + mainchain amide + two magnesium ions bound to Asn/Asp | M00196; Cyclin-dependent kinase 5
(Catalytic domains: 1.10.510.10, 3.30.200.20)
M00197; Casein kinase II subunit alpha
(Catalytic domains: 1.10.510.10, 3.30.200.20)
M00198; Phosphorylase b kinase regulatory subunit alpha
(Catalytic domains: 1.10.510.10, 3.30.200.20)
|
3.103.130000.358 | Transfer | Phosphate group from Phosphate oxygen to Hydroxyl oxygen | Insulin receptor-like mechanism | Asp/Arg + magnesium ion bound | M00136; Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor)AltName: CD_antigen=CD221;
(Catalytic domain: 1.10.510.10)
|
3.103.130000.1161 | Transfer | Phosphate group from Phosphate oxygen to Hydroxyl oxygen | Insulin receptor-like mechanism | Asp/Lys + two magnesium ions bound to Asp/Asn | M00125; Beta-adrenergic receptor kinase 1
(Catalytic domain: 1.10.510.10)
T00224; TGF-beta receptor type-1
(Catalytic domain: 1.10.510.10)
|
3.103.130000.1162 | Transfer | Phosphate group from Phosphate oxygen to Hydroxyl oxygen | Insulin receptor-like mechanism | Asp/Arg + two magnesium ions bound to Asp/Asn | M00124; Ephrin type-B receptor 2
(Catalytic domain: 1.10.510.10)
M00127; Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr)AltName: CD_antigen=CD331;
(Catalytic domain: 1.10.510.10)
M00129; Insulin receptor (IR) (EC 2.7.10.1)AltName: CD_antigen=CD220;
(Catalytic domain: 1.10.510.10)
M00130; Tyrosine-protein kinase ABL1
(Catalytic domain: 1.10.510.10)
M00131; Vascular endothelial growth factor receptor 1
(Catalytic domain: 1.10.510.10)
M00132; High affinity nerve growth factor receptor
(Catalytic domain: 1.10.510.10)
M00304; Tyrosine-protein kinase CSK
(Catalytic domain: 1.10.510.10)
M00323; Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog)AltName: CD_antigen=CD117;
(Catalytic domain: 1.10.510.10)
M00325; Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK)AltName: CD_antigen=CD202b;
(Catalytic domain: 1.10.510.10)
M00326; Proto-oncogene tyrosine-protein kinase receptor Ret
(Catalytic domain: 1.10.510.10)
M00327; Muscle
(Catalytic domain: 1.10.510.10)
M00328; ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase)AltName: CD_antigen=CD246;
(Catalytic domain: 1.10.510.10)
M00329; Macrophage-stimulating protein receptor (MSP receptor) (EC 2.7.10.1) (CDw136) (Protein-tyrosine kinase 8) (p185-Ron)AltName: CD_antigen=CD136;
(Catalytic domain: 1.10.510.10)
M00330; Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms)AltName: CD_antigen=CD115;
(Catalytic domain: 1.10.510.10)
M00331; Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1)AltName: CD_antigen=CD135;
(Catalytic domain: 1.10.510.10)
M00332; Tyrosine-protein kinase Mer
(Catalytic domain: 1.10.510.10)
M00333; Tyrosine-protein kinase ZAP-70
(Catalytic domain: 1.10.510.10)
M00335; Activated CDC42 kinase 1
(Catalytic domain: 1.10.510.10)
M00339; Tyrosine-protein kinase Fes/Fps
(Catalytic domain: 1.10.510.10)
M00344; Cytoplasmic tyrosine-protein kinase BMX
(Catalytic domain: 1.10.510.10)
|
3.105.230000.86 | Transfer | Phosphate group from Imine nitrogen (sp2) to Hydroxyl oxygen | PTS system-mannose-specific IIAB-like mechanism | His/Asp | D00527; PTS system mannose-specific EIIAB component
(Catalytic domain: 3.40.50.510)
|
3.105.250000.90 | Transfer | Phosphate group from Imine nitrogen (sp2) to Hydroxyl oxygen | PTS system-like mechanism | His + His/Arg | S00046; Lactose-specific phosphotransferase enzyme IIA component
(Catalytic domain: 1.20.58.80)
S00420; Nitrogen regulatory protein
(Catalytic domain: 3.40.930.10)
T00258; PTS system mannitol-specific EIICBA component
(Catalytic domain: 3.40.930.10)
|
3.105.250000.91 | Transfer | Phosphate group from Imine nitrogen (sp2) to Hydroxyl oxygen | PTS system-like mechanism | His + amide (dipole) | S00283; Fructose-specific phosphotransferase enzyme IIB component
(Catalytic domain: 3.40.35.10)
|
3.105.250000.48 | Transfer | Phosphate group from Imine nitrogen (sp2) to Hydroxyl oxygen | PTS system-like mechanism | Cys/Arg | D00525; PTS system glucose-specific EIICB component
(Catalytic domain: 3.30.1360.60)
S00297; N,N''-diacetylchitobiose-specific phosphotransferase enzyme IIB component
(Catalytic domain: 3.40.50.270)
|
3.110.90030.330 | Transfer | Phosphate group from Hydroxyl oxygen to Carboxyl oxygen | Thymidylate-kinase-like mechanism | Arg cluster + His + magnesium ion bound to acidic residues | T00217; Phosphoenolpyruvate carboxylase
(Catalytic domains: 1.20.1100.10, 3.20.20.60)
|
3.113.90000.331 | Transfer | Phosphate group from Phosphate oxygen to Carboxyl oxygen | Gro-PCT-like mechanism | Arg/Gln + magnesium ion bound to acidic residues | S00413; Aspartate--ammonia ligase
(Catalytic domain: 3.30.930.10)
|
3.113.90000.394 | Transfer | Phosphate group from Phosphate oxygen to Carboxyl oxygen | Gro-PCT-like mechanism | Lys/Arg cluster + magnesium ion bound to an acidic residue | M00049; Threonyl-tRNA synthetase
(Catalytic domain: 3.30.930.10)
|
3.113.90000.397 | Transfer | Phosphate group from Phosphate oxygen to Carboxyl oxygen | Gro-PCT-like mechanism | Lys/His/Asn + mainchain amide + magnesium ion bound | M00178; Glutaminyl-tRNA synthetase
(Catalytic domains: 1.10.1160.10, 3.40.50.620)
|
3.113.90020.1181 | Transfer | Phosphate group from Phosphate oxygen to Carboxyl oxygen | DNA polymerase-like mechanism | Lys/Asn + two magnesium ions bound to His/Glu/Ser | T00109; UDP-N-acetylmuramoylalanine--D-glutamate ligase
(Catalytic domain: 3.40.1190.10)
|
3.113.90020.1182 | Transfer | Phosphate group from Phosphate oxygen to Carboxyl oxygen | DNA polymerase-like mechanism | Lys + two magnesium ions bound to His/Glu/mainchain carbonyl | D00516; Folylpolyglutamate synthase
(Catalytic domain: 3.40.1190.10)
|
3.113.90030.330 | Transfer | Phosphate group from Phosphate oxygen to Carboxyl oxygen | Thymidylate-kinase-like mechanism | Arg cluster + His + magnesium ion bound to acidic residues | D00291; Lysyl-tRNA synthetase
(Catalytic domain: 3.30.930.10)
|
3.113.90030.1133 | Transfer | Phosphate group from Phosphate oxygen to Carboxyl oxygen | Thymidylate-kinase-like mechanism | Arg/Lys cluster + mainchain amide + two magnesium ions bound to acidic residues/Asn/Gln | M00051; Glutathione synthetase
(Catalytic domains: 1.10.1080.10, 3.30.470.20, 3.30.1490.50)
T00107; Glutathione synthetase
(Catalytic domains: 3.30.470.20, 3.30.1490.20)
|
3.113.90030.2130 | Transfer | Phosphate group from Phosphate oxygen to Carboxyl oxygen | Thymidylate-kinase-like mechanism | Arg cluster + three magnesium ions bound to acidic residues | D00295; Glycyl-tRNA synthetase
(Catalytic domain: 3.30.930.10)
|
3.113.90030.2131 | Transfer | Phosphate group from Phosphate oxygen to Carboxyl oxygen | Thymidylate-kinase-like mechanism | Arg cluster + three magnesium ions bound to acidic residue/[Ser or Thr] | D00293; Seryl-tRNA synthetase
(Catalytic domain: 3.30.930.10)
|
3.113.90040.334 | Transfer | Phosphate group from Phosphate oxygen to Carboxyl oxygen | D-alanine--poly(phosphoribitol) ligase 1st reaction step-like mechanism | Arg/Lys cluster + mainchain amide + magnesium ion bound to acidic residues | M00347; D-alanine--poly(phosphoribitol) ligase subunit 1
(Catalytic domains: 2.30.38.10, 3.30.300.30, 3.40.50.980)
|
3.113.163000.1110 | Transfer | Phosphate group from Phosphate oxygen to Carboxyl oxygen | NH(3)-dependent NAD+ synthetase phosphoryl transfer mechanism | Monovalent cation bound + magnesium ions bound to acidic residues | S00315; NH(3)-dependent NAD(+) synthetase
(Catalytic domain: 3.40.50.620)
|
3.113.310400.385 | Transfer | Phosphate group from Phosphate oxygen to Carboxyl oxygen | Succinyl-CoA synthetase phosphoryl transfer mechanism | His/Acidic residue + Arg/Thr + mainchain amide + magnesium bound to acidic residue/Asn or Gln | M00035; Succinyl-CoA ligase [GDP-forming] subunit alpha
(Catalytic domains: 3.30.470.20, 3.30.1490.20, 3.40.50.261)
|
3.123.90030.312 | Transfer | Phosphate group from Phosphate oxygen to Carbonyl oxygen | Thymidylate-kinase-like mechanism | Ser/Gly cluster + Lys + magnesium ion bound to acidic residues | T00114; GMP synthase {glutamine-hydrolyzing}
(Catalytic domains: 3.40.50.620, 3.40.50.880)
|
3.130.90020.2100 | Transfer | Phosphate group from Hydroxyl oxygen to Phosphate oxygen | DNA polymerase-like mechanism | Arg/Lys cluster + potassium ion bound to Ser/Thr/Asn/Asp + magnesium bound to acidic residues + magnesium bound to substrate/intermediate | T00043; Pyruvate kinase I
(Catalytic domains: 2.40.33.10, 3.20.20.60)
|
3.133.90010.334 | Transfer | Phosphate group from Phosphate oxygen to Phosphate oxygen | Adenylate-kinase-like mechanism | Arg/Lys cluster + mainchain amide + magnesium ion bound to acidic residues | S00465; Glucose-1-phosphate thymidylyltransferase 1
(Catalytic domain: 3.90.550.10)
|
3.133.90010.373 | Transfer | Phosphate group from Phosphate oxygen to Phosphate oxygen | Adenylate-kinase-like mechanism | His/Lys cluster + magnesium ion bound to acidic residue | S00318; Glycerol-3-phosphate cytidylyltransferase
(Catalytic domain: 3.40.50.620)
|
3.133.90010.389 | Transfer | Phosphate group from Phosphate oxygen to Phosphate oxygen | Adenylate-kinase-like mechanism | Lys/Arg/His cluster + magnesium ion bound to an acidic residue | S00548; Adenylate kinase
(Catalytic domain: 3.40.50.300)
|
3.133.90010.393 | Transfer | Phosphate group from Phosphate oxygen to Phosphate oxygen | Adenylate-kinase-like mechanism | Lys/Arg + magnesium ion bound to Asp/Asn | D00417; Bifunctional protein GlmU
(Catalytic domains: 2.160.10.10, 3.90.550.10)
|
3.133.90010.394 | Transfer | Phosphate group from Phosphate oxygen to Phosphate oxygen | Adenylate-kinase-like mechanism | Lys/Arg cluster + magnesium ion bound to an acidic residue | S00305; Adenylate kinase
(Catalytic domain: 3.40.50.300)
S00547; Adenylate kinase
(Catalytic domain: 3.40.50.300)
|
3.133.90030.334 | Transfer | Phosphate group from Phosphate oxygen to Phosphate oxygen | Thymidylate-kinase-like mechanism | Arg/Lys cluster + mainchain amide + magnesium ion bound to acidic residues | S00709; Glucose-1-phosphate cytidylyltransferase
(Catalytic domain: 3.90.550.10)
|
3.133.90030.336 | Transfer | Phosphate group from Phosphate oxygen to Phosphate oxygen | Thymidylate-kinase-like mechanism | Arg/His cluster + mainchain amide + magnesium ion bound | S00549; Nicotinamide-nucleotide adenylyltransferase
(Catalytic domain: 3.40.50.620)
|
3.133.90030.381 | Transfer | Phosphate group from Phosphate oxygen to Phosphate oxygen | Thymidylate-kinase-like mechanism | His/Lys/Arg cluster + mainchain amide + magnesium ion bound | S00316; Nicotinamide mononucleotide adenylyltransferase 1
(Catalytic domain: 3.40.50.620)
|
3.133.90030.383 | Transfer | Phosphate group from Phosphate oxygen to Phosphate oxygen | Thymidylate-kinase-like mechanism | His/Lys/Arg cluster + magnesium ion bound | S00317; Phosphopantetheine adenylyltransferase
(Catalytic domain: 3.40.50.620)
|
3.133.90030.392 | Transfer | Phosphate group from Phosphate oxygen to Phosphate oxygen | Thymidylate-kinase-like mechanism | Lys/Arg cluster + magnesium ion bound | S00308; Cytidylate kinase
(Catalytic domain: 3.40.50.300)
S00550; Cytidylate kinase
(Catalytic domain: 3.40.50.300)
|
3.133.90030.394 | Transfer | Phosphate group from Phosphate oxygen to Phosphate oxygen | Thymidylate-kinase-like mechanism | Lys/Arg cluster + magnesium ion bound to an acidic residue | D00130; Deoxynucleotide monophosphate kinase
(Catalytic domain: 3.40.50.300)
S00527; Thymidylate kinase
(Catalytic domain: 3.40.50.300)
|
3.133.90030.395 | Transfer | Phosphate group from Phosphate oxygen to Phosphate oxygen | Thymidylate-kinase-like mechanism | Lys/Arg/Tyr cluster + magnesium ion bound to acidic residue | D00129; Guanylate kinase
(Catalytic domains: 3.30.63.10, 3.40.50.300)
D00540; Guanylate kinase
(Catalytic domains: 3.30.63.10, 3.40.50.300)
|
3.133.90030.398 | Transfer | Phosphate group from Phosphate oxygen to Phosphate oxygen | Thymidylate-kinase-like mechanism | Lys/Arg cluster + magnesium ion bound to Ser or Thr | S00306; Thymidylate kinase
(Catalytic domain: 3.40.50.300)
|
3.133.91040.388 | Transfer | Phosphate group from Phosphate oxygen to Phosphate oxygen | HMP kinase 2nd reaction step-like mechanism | Lys + mainchain amide groups + magnesium ion bound to Thr | S00705; Phosphomethylpyrimidine kinase
(Catalytic domain: 3.40.1190.20)
|
3.133.300000.396 | Transfer | Phosphate group from Phosphate oxygen to Phosphate oxygen | mRNA capping enzyme-like mechanism | Lys/Asp + Arg/Lys/Asn/Asp cluster + magnesium or manganese ion bound | T00050; mRNA-capping enzyme
(Catalytic domains: 2.40.50.140, 3.90.63.10, 4.10.87.10)
|
3.133.305000.384 | Transfer | Phosphate group from Phosphate oxygen to Phosphate oxygen | DNA topoisomerase II autotransfer mechanism | His/Glu + Arg/His/Gln cluster + mainchain amide + magnesium ion bound | D00302; RNA 3''-terminal phosphate cyclase
(Catalytic domain: 3.65.10.20)
|
3.203.800.83 | Transfer | Sulfonic acid group from Phosphate oxygen to Hydroxyl Oxygen | Alcohol sulfotransferase-like mechanism | His/Lys/Ser | S00309; Bile salt sulfotransferase
(Catalytic domain: 3.40.50.300)
S00310; Estrogen sulfotransferase
(Catalytic domain: 3.40.50.300)
|
3.676.249900.37 | Transfer | Peroxide oxygen from peroxide oxygen to sulfur atom | 1-Cys-Peroxiredoxin 1st reaction step-like mechanism | Cys + Arg + [Thr or Ser] + mainchain amide groups | D00869; Hybrid peroxiredoxin hyPrx5
(Catalytic domain: 3.40.30.10)
D00870; 1-Cys peroxiredoxin
(Catalytic domain: 3.40.30.10)
S00916; Putative peroxiredoxin Rv2238c/MT2298
(Catalytic domain: 3.40.30.10)
|
3.707.20000.110 | Transfer | Methyl/Alkyl group from Sulfur atom to Hydroxyl oxygen | Cap specific mRNA (nucleoside-2'-O-)-methyltransferase-like mechanism | Lys cluster | S00412; Cap-specific mRNA (nucleoside-2''-O-)-methyltransferase
(Catalytic domain: 3.40.50.150)
|
3.707.90500.391 | Transfer | Methyl/Alkyl group from Sulfur atom to Hydroxyl oxygen | Catechol O-methyltransferase-like mechanism | Lys + magnesium ion bound to acidic residues/acceptor | S00291; Catechol O-methyltransferase
(Catalytic domain: 3.40.50.150)
|
3.717.19970.25 | Transfer | Methyl/Alkyl group from Sulfur atom to Carboxyl oxygen | Protein-repair-methyltransferase-like mechanism | Ser | D00823; Protein-L-isoaspartate O-methyltransferase
(Catalytic domain: 3.40.50.150)
S00639; Protein-L-isoaspartate O-methyltransferase
(Catalytic domain: 3.40.50.150)
|
3.747.6300.267 | Transfer | Methyl/Alkyl group from Sulfur atom to Amine nitrogen (sp3) | Modification methylase RsrI-like mechanism | ionized Asp or Glu | D00079; Modification methylase DpnIIA
(Catalytic domain: 3.40.50.150)
S00261; Modification methylase RsrI
(Catalytic domain: 3.40.50.150)
|
3.747.6310.11 | Transfer | Methyl/Alkyl group from Sulfur atom to Amine nitrogen (sp3) | Modification methylase-PvuII-like mechanism | Ser/Asp | S00262; Modification methylase PvuII
(Catalytic domain: 3.40.50.150)
|
3.747.29000.21 | Transfer | Methyl/Alkyl group from Sulfur atom to Amine nitrogen (sp3) | rRNA adenine N-6-methyltransferase-like mechanism | Asn/mainchain carbonyl + aromatic residues | D00076; rRNA adenine N-6-methyltransferase
(Catalytic domain: 3.40.50.150)
D00080; Modification methylase TaqI
(Catalytic domain: 3.40.50.150)
|
3.748.90280.5472 | Transfer | Methyl/Alkyl group from Carbon (sp3) atom to Amine nitrogen (sp3) | Serine hydroxymethyltransferase-like mechanism | Two acidic residues + PLP double-bonded to substrate/intermediate | D00085; Serine hydroxymethyltransferase
(Catalytic domain: 3.40.640.10)
|
3.770.220000.47 | Transfer | Methyl/Alkyl group from Hydroxyl oxygen to Sulfur atom | 6-O-methylguanine-DNA methyltransferase-like mechanism | Cys/His/Tyr/Glu/Asn | D00077; Methylated-DNA--protein-cysteine methyltransferase
(Catalytic domain: 1.10.10.10)
D00517; Methylated-DNA--protein-cysteine methyltransferase
(Catalytic domain: 1.10.10.10)
|
3.797.810.4110 | Transfer | Methyl/Alkyl group from Sulfur atom to Carbon (double-bonded; sp2) | Modification methylase-HaeIII methyl transfer mechanism | Glu/Arg + mainchain carbonyl + Cys covalently bound to substrate/intermediate | D00082; Modification methylase HaeIII
(Catalytic domain: 3.40.50.150)
|
3.900.45300.71 | Transfer | Glycosyl group from Hydroxyl oxygen to Hydroxyl oxygen | Anhydrosialidase-like mechanism | Asp/Glu/Tyr | T00064; Anhydrosialidase
(Catalytic domain: 2.120.10.10)
|
3.900.275800.990 | Transfer | Glycosyl group from Hydroxyl oxygen to Hydroxyl oxygen | Cyclodextrin-glycosyltransferase-like mechanism | Three acidic residues + His | M00113; Cyclomaltodextrin glucanotransferase
(Catalytic domain: 3.20.20.80)
S00202; 4-alpha-glucanotransferase
(Catalytic domain: 3.20.20.80)
T00307; 1,4-alpha-glucan branching enzyme GlgB
(Catalytic domain: 3.20.20.80)
|
3.903.70210.354 | Transfer | Glycosyl group from Phoshate oxygen to Hydroxyl oxygen | DNA beta-glucosyltransferase-like mechanism | Asp + magnesium ion bound to Asp | D00403; DNA beta-glucosyltransferase
(Catalytic domain: 3.40.50.2000)
|
3.903.70210.640 | Transfer | Glycosyl group from Phoshate oxygen to Hydroxyl oxygen | DNA beta-glucosyltransferase-like mechanism | An acidic residue + manganese ion bound to an acidic residue | T00415; Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
(Catalytic domain: 3.90.550.10)
|
3.903.137500.660 | Transfer | Glycosyl group from Phoshate oxygen to Hydroxyl oxygen | EXTL2-acetylhexosaminyltransferase-like mechanism | Arg + mainchain amide + Asn/Asp + manganese ion bound to an acidic residue | D00860; Exostosin-like 2
(Catalytic domain: 3.90.550.10)
|
3.940.275890.113 | Transfer | Glycosyl group from Hydroxyl oxygen to Amine nitrogen (sp3) | Endonuclease III glycosyl transfer mechanism | Lys + two acidic residues | D00266; Endonuclease III
(Catalytic domains: 1.10.340.30, 1.10.1670.10)
|
3.943.120000.356 | Transfer | Glycosyl group from Phosphate oxygen to Amine nitrogen (sp3) | Uracil phosphoribosyltransferase-like mechanism | Asp/Asp/Asp + magnesium ion bound | S00287; Uracil phosphoribosyltransferase
(Catalytic domain: 3.40.50.2020)
|
3.943.131000.356 | Transfer | Glycosyl group from Phosphate oxygen to Amine nitrogen (sp3) | Xanthine phosphoribosyltransferase-like mechanism | Asp/Asp/Asp + magnesium ion bound | S00289; Xanthine phosphoribosyltransferase
(Catalytic domain: 3.40.50.2020)
|
3.944.220700.2 | Transfer | Glycosyl group from Amine nitrogen (sp3) to Amine nitrogen (sp3) | TGT-like mechanism | Two acidic residues | S00230; Queuine tRNA-ribosyltransferase
(Catalytic domain: 3.20.20.105)
|
3.944.290000.2 | Transfer | Glycosyl group from Amine nitrogen (sp3) to Amine nitrogen (sp3) | Nucleoside deoxyribosyltransferase-like mechanism | Two acidic residues | S00377; Nucleoside deoxyribosyltransferase
(Catalytic domain: 3.40.50.1810)
|
3.955.50030.967 | Transfer | Glycosyl group from Imine nitrogen (sp2) to Imine nitrogen (sp2) | NAD+ ADP-ribosyltransferase-like mechanism | Two acidic residues + Arg cluster | D00463; Vip2Ac
(Catalytic domain: 3.90.176.10)
|
3.1103.6090.130 | Transfer | Acyl group from Phosphate oxygen to Hydroxyl oxygen | Glutaminyl-tRNA synthetase acyl transfer mechanism | An acidic residue + Lys/His/Arg + mainchain amide | M00178; Glutaminyl-tRNA synthetase
(Catalytic domains: 1.10.1160.10, 3.40.50.620)
|
3.1107.6300.74 | Transfer | Acyl group from Sulfur atom to Hydroxyl oxygen | Modification methylase RsrI-like mechanism | His | D00464; Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
(Catalytic domain: 2.160.10.10)
|
3.1107.220190.41 | Transfer | Acyl group from Sulfur atom to Hydroxyl oxygen | Arylamine N-acetyltransferase-like mechanism | Cys/His/Asp + mainchain amide | D00508; N-hydroxyarylamine O-acetyltransferase
(Catalytic domain: 2.40.128.40)
|
3.1143.50000.64 | Transfer | Acyl group from Phosphate oxygen to Amine nitrogen (sp3) | Aspartate--ammonia ligase acyl transfer mechanism | Asp/Arg/Gln | S00413; Aspartate--ammonia ligase
(Catalytic domain: 3.30.930.10)
|
3.1143.70030.3060 | Transfer | Acyl group from Phosphate oxygen to Amine nitrogen (sp3) | NH(3)-dependent NAD+ synthetase acyl transfer mechanism | Asp + monovalent cation bound | S00315; NH(3)-dependent NAD(+) synthetase
(Catalytic domain: 3.40.50.620)
|
3.1143.80000.1190 | Transfer | Acyl group from Phosphate oxygen to Amine nitrogen (sp3) | Folylpolyglutamate synthase acyl transfer mechanism | His + two magnesium ions bound | D00516; Folylpolyglutamate synthase
(Catalytic domain: 3.40.1190.10)
T00109; UDP-N-acetylmuramoylalanine--D-glutamate ligase
(Catalytic domain: 3.40.1190.10)
|
3.1143.90000.1132 | Transfer | Acyl group from Phosphate oxygen to Amine nitrogen (sp3) | Gro-PCT-like mechanism | Arg cluster + mainchain amide + two magnesium ions bound to acidic residues/Asn/Gln | M00051; Glutathione synthetase
(Catalytic domains: 1.10.1080.10, 3.30.470.20, 3.30.1490.50)
T00107; Glutathione synthetase
(Catalytic domains: 3.30.470.20, 3.30.1490.20)
|
3.1144.1800.89 | Transfer | Acyl group from Amine nitrogen (sp3) to Amine nitrogen (sp3) | Methionyl-tRNA formyltransferase-like mechanism | His/Asn/Asp | D00087; Methionyl-tRNA formyltransferase
(Catalytic domain: 3.40.50.170)
S00294; Phosphoribosylglycinamide formyltransferase
(Catalytic domain: 3.40.50.170)
|
3.1144.220195.34 | Transfer | Acyl group from Amine nitrogen (sp3) to Amine nitrogen (sp3) | Cofactor-dependent-phosphoglycerate-mutase-like mechanism | Thr(N-terminal) + N-terminal alpha-amine + Thr + mainchain amide | T00418; Gamma-glutamyltranspeptidase
(Catalytic domain: 3.60.20.10)
|
3.1147.900.95 | Transfer | Acyl group from Sulfur atom to Amine nitrogen (sp3) | Serotonin N-acetyltransferase-like mechanism | Tyr/His/His + mainchain amide | S00410; Serotonin N-acetyltransferase
(Catalytic domain: 3.40.630.30)
|
3.1147.6000.72 | Transfer | Acyl group from Sulfur atom to Amine nitrogen (sp3) | Histone acetyltransferase type B-like mechanism | Glu/hydrophobic residues + mainchain amide | M00165; General control of amino acid synthesis protein 5-like 2
(Catalytic domain: 3.40.630.30)
T00034; Histone acetyltransferase type B catalytic subunit
(Catalytic domain: 3.40.630.30)
|
3.1147.6010.88 | Transfer | Acyl group from Sulfur atom to Amine nitrogen (sp3) | Glucosamine-1-phosphate N-acetyltransferase-like mechanism | His/Glu/Ser + mainchain amide | D00417; Bifunctional protein GlmU
(Catalytic domains: 2.160.10.10, 3.90.550.10)
|
3.1147.37500.97 | Transfer | Acyl group from Sulfur atom to Amine nitrogen (sp3) | Histone acetyltransferase HPA2-like mechanism | Tyr + Tyr/mainchain amide + Hydrophobic residues/mainchain carbonyl | S00409; Histone acetyltransferase HPA2
(Catalytic domain: 3.40.630.30)
|
3.1147.47600.180 | Transfer | Acyl group from Sulfur atom to Amine nitrogen (sp3) | NMT-like mechanism | C-terminal carboxylate + Asn + mainchain amide groups + Thr or Ser + mainchain carbonyl | D00413; Glycylpeptide N-tetradecanoyltransferase
(Catalytic domain: 3.40.630.30)
|
3.1177.805.79 | Transfer | Acyl group from Sulfur atom to Sulfur atom | Dihydrolipoamide-succinyltransferase-like mechanism | His/Asn + mainchain carbonyl + a residue with hydroxyl group [Ser or Thr] | M00189; Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
(Catalytic domain: 3.30.559.10)
|
3.1177.805.87 | Transfer | Acyl group from Sulfur atom to Sulfur atom | Dihydrolipoamide-succinyltransferase-like mechanism | His/Asp/Arg + mainchain carbonyl + a residue with hydroxyl group [Ser or Thr] | M00188; Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
(Catalytic domain: 3.30.559.10)
M00190; Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
(Catalytic domain: 3.30.559.10)
T00223; Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex
(Catalytic domain: 3.30.559.10)
|
3.1177.220080.38 | Transfer | Acyl group from Sulfur atom to Sulfur atom | Beta-ketoacyl-ACP synthase III 1st reaction step-like mechanism | Cys + an acidic residue + [Ser or Thr] + His/Asn + mainchain amide groups | D00825; 3-oxoacyl-[acyl-carrier-protein] synthase 3
(Catalytic domain: 3.40.47.10)
D00826; 3-oxoacyl-[acyl-carrier-protein] synthase 3
(Catalytic domain: 3.40.47.10)
D00867; 3-oxoacyl-[acyl-carrier-protein] synthase 3
(Catalytic domain: 3.40.47.10)
|
3.1177.220085.58 | Transfer | Acyl group from Sulfur atom to Sulfur atom | Beta-ketoacyl-ACP synthase II 1st reaction step-like mechanism | Cys + His/His/Lys + mainchain amide groups | D00871; 3-oxoacyl-[acyl-carrier-protein] synthase 2
(Catalytic domain: 3.40.47.10)
|
3.1187.65790.5550 | Transfer | Acyl group from Sulfur atom to Carbon (sp3) | glycine acetyltransferase mechanism | Lys/Ser + PLP double-bonded to substrate/intermediate | D00639; 2-amino-3-ketobutyrate coenzyme A ligase
(Catalytic domain: 3.40.640.10)
|
3.1187.70500.5510 | Transfer | Acyl group from Sulfur atom to Carbon (sp3) | 8-amino-7-oxononanoate synthase acyl transfer mechanism | Lys/His + PLP double-bonded to substrate/intermediate | D00092; 8-amino-7-oxononanoate synthase
(Catalytic domains: 3.40.640.10, 3.90.1150.10)
|
3.1197.15020.136 | Transfer | Acyl group from Sulfur atom to Carbon (double-bonded; sp2) | Beta-ketoacyl-ACP synthase III 3rd reaction step-like mechanism | An acidic residue + [Ser or Thr] + mainchain amide groups + His + [Asn or Gln] + Cys covalently-bound to substrate/intermediate | D00825; 3-oxoacyl-[acyl-carrier-protein] synthase 3
(Catalytic domain: 3.40.47.10)
D00826; 3-oxoacyl-[acyl-carrier-protein] synthase 3
(Catalytic domain: 3.40.47.10)
D00867; 3-oxoacyl-[acyl-carrier-protein] synthase 3
(Catalytic domain: 3.40.47.10)
|
3.1197.15025.150 | Transfer | Acyl group from Sulfur atom to Carbon (double-bonded; sp2) | Beta-ketoacyl-ACP synthase II 3rd reaction step-like mechanism | His + mainchain amide groups + Cys covalently-bound to substrate/intermediate | D00871; 3-oxoacyl-[acyl-carrier-protein] synthase 2
(Catalytic domain: 3.40.47.10)
|
3.1244.220200.43 | Transfer | Amidino group from Amine nitrogen (sp3) to Amine nitrogen (sp3) | Glycine amidinotransferase-like mechanism | Cys/His/Asp/Asp + acidic residue | S00440; Glycine amidinotransferase
(Catalytic domain: 3.75.10.10)
|
4.12.18410.92 | Addition to double-bond | Water (H2O; hydration) to Imine carbon (sp2) [leading to hydorxyl group & amine group] | Creatinase-like addition mechanism | His + two acidic residues | D00244; Creatinase
(Catalytic domain: 3.90.230.10)
|
4.12.642300.465 | Addition to double-bond | Water (H2O; hydration) to Imine carbon (sp2) [leading to hydorxyl group & amine group] | Base-Acid/Stabilizer; Base activation of added group; Inorganic-cofactor-assisted added group attacks on addition site; Simultaneous acid protonation to protonation site; Stabilization of group adjacent to addition site mechanism | Glu + mainchain carbonyl + zinc ion bound to Cys/His cluster | D00406; Cytidine deaminase
(Catalytic domain: 3.40.140.10)
S00808; Deoxycytidylate deaminase
(Catalytic domain: 3.40.140.10)
S00810; Guanine deaminase
(Catalytic domain: 3.40.140.10)
|
4.12.642320.458 | Addition to double-bond | Water (H2O; hydration) to Imine carbon (sp2) [leading to hydorxyl group & amine group] | Adenosine deaminase 1st reaction step-like mechanism | Asp/Glu/His + zinc ion bound to His/(acidic residue) cluster | D00873; Guanine deaminase
(Catalytic domain: 3.20.20.140)
S00232; Adenosine deaminase
(Catalytic domain: 3.20.20.140)
|
4.12.642320.562 | Addition to double-bond | Water (H2O; hydration) to Imine carbon (sp2) [leading to hydorxyl group & amine group] | Adenosine deaminase 1st reaction step-like mechanism | Asp/Glu/His + Fe(II) ion bound to His/(acidic residue) cluster | D00675; Cytosine deaminase
(Catalytic domain: 3.20.20.140)
|
4.15.898500.454 | Addition to double-bond | Water (H2O; hydration) to CO2 [leading to hydorxyl group & carboxylate; fixation of CO2] | Base-stabilizer/Stabilizer; Inorganic-cofactor-assisted activation of added group by base; Added group stabilized; Addition-site stabilized; Activated added group attacks on the addition-site mechanism | Asp/Gly + zinc ion bound to Cys/Cys/His cluster | S00521; Carbonic anhydrase
(Catalytic domain: 3.40.1050.10)
|
4.15.898510.455 | Addition to double-bond | Water (H2O; hydration) to CO2 [leading to hydorxyl group & carboxylate; fixation of CO2] | Base-stabilizer/Stabilizer/Proton-shuttle; Inorganic-cofactor-assisted base activation of added group through proton-shuttle; Added group stabilized; Addition-site of unsaturated group stabilized; Activated added group attacks on the addition-site mechanism | Asp/Gln/Tyr + zinc ion bound to Cys/Cys/His cluster | D00474; Carbonic anhydrase
(Catalytic domain: 3.40.1050.10)
|
4.15.898520.455 | Addition to double-bond | Water (H2O; hydration) to CO2 [leading to hydorxyl group & carboxylate; fixation of CO2] | Base-proton-shuttle-stabilizer/Stabilizer/proton-shuttle; Inorganic-cofactor-assisted activation of added group by base-proton-shuttle; Added group stabilized; Addition-site of unsaturated group stabilized; Activated added group attacks on the addition-site of unsaturated group mechanism | Asp/Gln/Tyr + zinc ion bound to Cys/Cys/His cluster | S00424; Carbonic anhydrase
(Catalytic domain: 3.40.1050.10)
|
4.15.1107000.480 | Addition to double-bond | Water (H2O; hydration) to CO2 [leading to hydorxyl group & carboxylate; fixation of CO2] | Base-stabilizer/Proton-shuttle/Stabilizer; Inorganic-cofactor-assisted base deprotonation of added group through proton shuttle; Addition-site of unsaturated group stabilized; Activated added group attacks on the addition-site mechanism | Two acidic residues + Arg/Gln/Asn + zinc ion bound to His cluster | S00167; Carbonic anhydrase
(Catalytic domain: 2.160.10.10)
|
4.16.66400.4 | Addition to double-bond | Water (H2O; hydration) to sp2-like Carbon (C=O-PO3) [leading to HO-C-OPO3] | Base/Base; Base deprotonation of added group; Activated added group attacks on addition site of unsaturated group; 2nd base deprotonation of protonated 1st base mechanism | An acidic residue + His | S00532; 2-dehydro-3-deoxyphosphooctonate aldolase
(Catalytic domain: 3.20.20.70)
|
4.16.66400.7 | Addition to double-bond | Water (H2O; hydration) to sp2-like Carbon (C=O-PO3) [leading to HO-C-OPO3] | Base/Base; Base deprotonation of added group; Activated added group attacks on addition site of unsaturated group; 2nd base deprotonation of protonated 1st base mechanism | An acidic residue + Lys | S00243; Phospho-2-dehydro-3-deoxyheptonate aldolase
(Catalytic domain: 3.20.20.70)
|
4.23.18400.69 | Addition to double-bond | Hydroxyl oxygen to Carbon (sp2) (with carboxylate group) | UDP-N-acetylglucosamine 1-carboxyvinyltransferase-like addition mechanism | Asp/Cys/Asn | D00415; UDP-N-acetylglucosamine 1-carboxyvinyltransferase
(Catalytic domain: 3.65.10.10)
|
4.121.143000.6100 | Addition to double-bond | Carbon (sp3) (adjacent to double-bonded sp2 carbon ) to Carbonyl carbon (sp2) | Acid; Added group attacks on addition site of unsaturated group to form covalent bond; Acid protonation to protonation site of unsaturated group mechanism | An acidic residue + Lys double-bonded to substrate/intermediate | S00198; Transaldolase B
(Catalytic domain: 3.20.20.70)
|
4.151.766500.451 | Addition to double-bond | Carbon (sp2) (C=C-O) to Carbonyl carbon (sp2) | Modulator-Acid/Stabilizer; Inorganic-cofactor-assisted stabilization of added group of substrate; Modulator-assisted activation of electrophilic unsaturated group; Added group attacks on unsaturated group forming covalent bond; Acid protonation to protonation site of unsaturated group mechanism | An acidic residue + Asn (or Gln) + zinc ion bound to His cluster | S00235; Fructose-bisphosphate aldolase class 2
(Catalytic domain: 3.20.20.70)
|
4.151.774000.401 | Addition to double-bond | Carbon (sp2) (C=C-O) to Carbonyl carbon (sp2) | Acid; Inorganic-cofactor-assisted activation of protonation site of unsaturated group; Added group attacks on addition site of unsaturated group; Acid protonation to protonation site of unsaturated group mechanism | Lys + a divalent metal bound to substrate/Cys/His/Acidic residues | S00243; Phospho-2-dehydro-3-deoxyheptonate aldolase
(Catalytic domain: 3.20.20.70)
S00532; 2-dehydro-3-deoxyphosphooctonate aldolase
(Catalytic domain: 3.20.20.70)
|
4.162.20000.1 | Addition to double-bond | Carbon (sp2) (C=C-N) to Imine carbon (sp2) | Base-Acid; Base activation of added group; Nucleophilic attack on addition site of unsaturated group by added group; substrate-assisted base deprotonates addition site of added group through water; Acid protonation to 2-bonds away from addition site of added group mechanism | An acidic resdiue | S00276; Deoxycytidylate 5-hydroxymethyltransferase
(Catalytic domain: 3.30.572.10)
|
4.191.350400.117 | Addition to double-bond | Aromatic carbon (sp2) (C=C-N) to Carbonyl carbon (sp2) [leading to hydorxyl group & imine group] | Acid/Modulator-Stabilizer/Stabilizer/Modulator; Acid protonation to protonation site of unsaturated group; Electrophilic addition site attacks on added group; Modulation of addition site and added group through other site; Modulator-asisted reprotonation of acid mechanism | Lys/Lys + two acidic residues | S00826; Indole-3-glycerol phosphate synthase
(Catalytic domain: 3.20.20.70)
|
4.202.112900.6000 | Addition to double-bond | Amine group (sp3 nitrogen) to Imine carbon (sp2) | Substrate-assisted-Base-Acid; Substrate-base activation of added group; Activated added group attacks on addition site of unsaturated group; Substrate-acid protonation to protonation site of unsaturated group mechanism | Lys double-bonded to substrate/intermediate | S00239; Delta-aminolevulinic acid dehydratase
(Catalytic domain: 3.20.20.70)
S00538; Delta-aminolevulinic acid dehydratase
(Catalytic domain: 3.20.20.70)
|
4.202.3822800.1 | Addition to double-bond | Amine group (sp3 nitrogen) to Imine carbon (sp2) | Base; Base deprotonation of added group; Activated added group attacks on the addition-site mechanism | An acidic resdiue | D00085; Serine hydroxymethyltransferase
(Catalytic domain: 3.40.640.10)
|
4.501.3813400.59 | Addition to double-bond | Sulfur to Carbonyl carbon (sp2) | Betaine aldehyde dehydrogenase 1st reaction step-like mechanism | Cys + an acidic residue + [Asn or Gln] + mainchain amide group | D00021; Betaine aldehyde dehydrogenase
(Catalytic domains: 3.40.309.10, 3.40.605.10)
|
4.501.3944060.57 | Addition to double-bond | Sulfur to Carbonyl carbon (sp2) | GDP mannose dehydrogenase 2nd reaction step-like mechanism | Cys/Lys + Lys/Asp/Thr | T00227; UDP-glucose 6-dehydrogenase
(Catalytic domains: 1.10.1040.10, 3.40.50.720)
T00408; GDP-mannose 6-dehydrogenase
(Catalytic domains: 1.-.-.-, 3.40.50.720)
|
4.504.771000.5521 | Addition to double-bond | Sulfur to Carbon (sp2) adjacent to double-bond | Acid/Modulator; Added group attacks on addition site of unsaturated group; Organic-cofactor bound to unsaturated group stabilizes intermediate; Modulator-assisted acid protonation to protonation site of unsaturated group mechanism | Lys/Tyr + PLP covalently bound to substrate/intermediate | D00265; Cystathionine gamma-synthase
(Catalytic domain: 3.40.640.10)
|
4.1010.695600.8301 | Addition to double-bond | Water (H2O; hydration) to Carbon (sp2) adjacent to double-bond; Opposition to non-beta-elimination | 6-phospho-alpha-glucosidase 4th reaction step-like mechanism | An acidic residue + manganese ion bound to Cys/His/O7-nicotinamide/substrate or intermediate | D00827; Maltose-6''-phosphate glucosidase
(Catalytic domain: 3.90.110.10)
|
4.1034.143290.135 | Addition to double-bond | Carboxylate oxygen to Carbon (sp2) adjacent to double-bond; Opposition to non-beta-elimination | Metal-independent eukaryotic MLE-like mechanism | An acidic residue + Arg cluster | S00852; Carboxy-cis,cis-muconate cyclase
(Catalytic domain: 2.130.10.10)
|
4.1034.769660.650 | Addition to double-bond | Carboxylate oxygen to Carbon (sp2) adjacent to double-bond; Opposition to non-beta-elimination | Metal-dependent bacterial MLE-like mechanism | An acidic residue + Lys + manganese ion bound to acidic residues | D00282; Muconate cycloisomerase 1
(Catalytic domain: 3.20.20.120)
D00283; Chloromuconate cycloisomerase
(Catalytic domain: 3.20.20.120)
|
4.1164.693000.5470 | Addition to double-bond | Carbon (sp2) (C=C-N) to Carbon (sp2) adjacent to double-bond; Opposition to non-beta-elimination | Base; Added group attacks on addition site of unsaturated group; Organic-cofactor bound to unsaturated group stabilizes intermediate; Base deprotonation of addition site of added group mechanism | An acidic residue + PLP double-bonded to substrate/intermediate | T00089; Tryptophan synthase alpha chain
(Catalytic domains: 3.20.20.70, 3.40.50.1100)
|
4.1244.165000.313 | Addition to double-bond | Nitrogen atom in aromatic ring (sp2 nitrogen group) to Carbon (sp2) adjacent to double-bond; Opposition to non-beta-elimination | Modulator/Stabilizer; Stabilization of protonation site of unsaturated group & Modulation of addition site of unsaturated group and substrate-assisted acid; Inorganic-cofactor-asisted stabilization of substrate-assisted acid; Added group attacks on unsaturated group & Substrate-assisted acid protonation to protonation site of unsaturated group mechanism | Ser/Gln + magnesium ion bound to acidic residues/phosphate | S00220; Thiamine-phosphate pyrophosphorylase
(Catalytic domain: 3.20.20.70)
|
4.1504.3900000.53 | Addition to double-bond | Sulfur to Carbon (sp2) adjacent to double-bond; Opposition to non-beta-elimination | Nucleophile/Acid; Nucleophile attacks on addition site of unsaturated group; Acid protonates protonation site of unsaturated group mechanism | Cys + an acidic residue | S00276; Deoxycytidylate 5-hydroxymethyltransferase
(Catalytic domain: 3.30.572.10)
|
4.1514.818600.1130 | Addition to double-bond | Sulfur to Carbon (sp2) adjacent to double-bond; Opposition to non-beta-elimination | Stabilizer; Stabilization of protonation site of unsaturated group by inorganic cofactor; Stabilized added group attacks on addition site of unsaturated group mechanism | Arg cluster + two magnesium ions bound to acidic residues | S00841; Phosphosulfolactate synthase
(Catalytic domain: 3.20.20.70)
|
5.10.9510.969 | Eliminative double-bond formation | Hydroxyl group (dehydration) from Carbon (sp3) | dTDP glucose dehydratase 2nd reaction step-like mechanism | Two acidic residues + Tyr/Thr | D00262; dTDP-glucose 4,6-dehydratase 2
(Catalytic domain: 3.40.50.720)
|
5.10.12500.6010 | Eliminative double-bond formation | Hydroxyl group (dehydration) from Carbon (sp3) | Base-Acid/Modulator; Base deprotonates deprotonation site; Intermediate formation stabilized by tautomerization; Acid protonates eliminated group leading to bond cleavage; E1Cb-like reaction mechanism | His/Glu + Lys double-bonded to substrate/intermediate | S00240; 3-dehydroquinate dehydratase
(Catalytic domain: 3.20.20.70)
|
5.10.68000.77 | Eliminative double-bond formation | Hydroxyl group (dehydration) from Carbon (sp3) | Base-Acid/Stabilizer/Modulators; Base deprotonates deprotonation site; Intermediate formation stabilized; Modulator-activated water protonates leaving group (non-deprotonation/elimination site) & Acid protonation to eliminated group leading to bond cleavage; Water deprotonates leaving group (non-deprotonation/elimination site) ; E1cb-like reaction mechanism | His + His+ Asp + Tyr cluster | S00176; Scytalone dehydratase
(Catalytic domain: 3.10.450.50)
|
5.10.552200.114 | Eliminative double-bond formation | Hydroxyl group (dehydration) from Carbon (sp3) | Base/Acid; Acid protonation to eliminated group; Base deprotonation of dedeprotonation site leading to bond cleavage; E2-like reaction mechanism | Lys/Glu | S00826; Indole-3-glycerol phosphate synthase
(Catalytic domain: 3.20.20.70)
|
5.12.1132000.75 | Eliminative double-bond formation | Hydroxyl group (dehydration) from Carbon (sp3) (with amine group) [leading to imine group] | Base-Acid/Acid/Modulator/Stabilizer; Modulator-activated base deprotonates leaving group (non-deprotonation/elimination site); Intermediate formation stabilized; Acid protonation to eliminated group leading to bond cleavage; Water deprotonates deprotonation site of leaving group; 2nd Acid protonates leaving group (non-deprotonation/elimination site); E1-like reaction mechanism | His/His + acidic residues + mainchain amide | S00254; Pterin-4-alpha-carbinolamine dehydratase
(Catalytic domain: 3.30.1360.20)
|
5.12.1497400.1 | Eliminative double-bond formation | Hydroxyl group (dehydration) from Carbon (sp3) (with amine group) [leading to imine group] | Acid; Acid protonation to eliminated group; E1-like reaction mechanism | An acidic resdiue | S00226; 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
(Catalytic domain: 3.20.20.70)
S00847; N-(5''-phosphoribosyl)anthranilate isomerase
(Catalytic domain: 3.20.20.70)
|
5.12.1504210.1 | Eliminative double-bond formation | Hydroxyl group (dehydration) from Carbon (sp3) (with amine group) [leading to imine group] | Acid; Acid protonation to eliminated group completes reaction; E1-like reaction mechanism | An acidic resdiue | D00085; Serine hydroxymethyltransferase
(Catalytic domain: 3.40.640.10)
|
5.14.411700.1 | Eliminative double-bond formation | Hydroxyl group (dehydration) from Carbon (sp3) adjacent to double-bond | GDP mannose dehydratase 3rd reaction step-like mechanism | An acidic residue | D00513; GDP-mannose 4,6 dehydratase 2
(Catalytic domains: 3.40.50.720, 3.90.25.10)
D00543; GDP-mannose 4,6-dehydratase
(Catalytic domains: 3.40.50.720, 3.90.25.10)
|
5.14.3200000.372 | Eliminative double-bond formation | Hydroxyl group (dehydration) from Carbon (sp3) adjacent to double-bond | Acid/Stabilizer; Acid protonation to eliminated group leading to bond cleavage; Inorganic cofactor-assisted stabilization of intermediate; Inorganic cofactor contribution to leaving group (non-deprotonation/elimination site); E1-like reaction mechanism | His + Tyr/Lys/Asn + magnesium ion bound to Asp/Glu/Asn | D00261; Glucarate dehydratase
(Catalytic domain: 3.20.20.120)
|
5.14.3250000.5471 | Eliminative double-bond formation | Hydroxyl group (dehydration) from Carbon (sp3) adjacent to double-bond | Acid; Acid protonation to eliminated group; Organic cofactor-assisted bond cleavage; E1-like reaction mechanism | An acidic residue + PLP covalently bound to substrate/intermediate | T00089; Tryptophan synthase alpha chain
(Catalytic domains: 3.20.20.70, 3.40.50.1100)
|
5.20.8010.94 | Eliminative double-bond formation | O-glycoside group from Carbon (sp3) | Base-Acid/Stabilizer/Modulator; Modulater-activated base deprotonates deprotonation site; Intermediate formation stabilized; Acid protonates eliminated group leading to cleavage; E1Cb-like reaction mechanism | Tyr/His/Arg | D00518; Alginate lyase
(Catalytic domain: 1.50.10.110)
|
5.20.1641500.532 | Eliminative double-bond formation | O-glycoside group from Carbon (sp3) | Base/Acid/Stabilizer; Inorganic-cofactor-stabilization of functional group adjacent to deprotonation site leading to modulation of deprotonation site; Base deprotonation of deprotonation site of leaving group; Intermediate formation; Stabilization of eliminated group & Acid protonation to eliminated group leading to bond cleavage; E1cb-like reaction mechanism | Lys + an acidic residue + Arg + calcium ion bound to Asn + two acidic residues | S00837; Chondroitinase-B
(Catalytic domain: 2.160.20.10)
|
5.20.1710000.530 | Eliminative double-bond formation | O-glycoside group from Carbon (sp3) | Base/Stabilizer; Substrate-assisted modulation of base; Inorganic cofactor-assisted base deprotonation of deprotonation site; Inorganic cofactor-assisted stabilization of intermediate formation; Water protonation to eliminated group; E1cb-like reaction mechanism | Arg/Lys + calcium ion bound to acidic residues | S00169; Pectate lyase C
(Catalytic domain: 2.160.20.10)
S00546; Pectate lyase
(Catalytic domain: 2.160.20.10)
|
5.21.14000.74 | Eliminative double-bond formation | O-glycoside group from Carbon (sp3) (with hydroxyl group) [leading to carbonyl group] | Base-Acid; Base deprotonates deprotonation site; Acid protonates eliminated group leading to bond cleavage; E1Cb-like reaction mechanism | His | T00201; Glucosamine--fructose-6-phosphate aminotransferase {isomerizing}
(Catalytic domains: 3.40.50.10490, 3.60.20.10)
|
5.30.1645000.5521 | Eliminative double-bond formation | Carboxyl ester (oxygen) from Carbon (sp3) | Base/Acid; Base deprotonation of deprotonation site of leaving group; Intermediate formation; Acid protonation to eliminated group leading to bond cleavage; E1cb-like reaction; Organic-cofactor-assisted reaction mechanism | Lys/Tyr + PLP covalently bound to substrate/intermediate | D00265; Cystathionine gamma-synthase
(Catalytic domain: 3.40.640.10)
|
5.41.2776000.400 | Eliminative double-bond formation | Phosphoryl oxygen (O3P-O-) from Carbon (sp3) (with hydroxyl group) [leading to carbonyl group] | Acid-Base/Stabilizer; Inorganic cofactor-assisted stabilization of group attached to elimination site of leaving group; Acid protonation to elimination group; Base deprotonation of deprotonation site of leaving group; Stabilization of eliminated group facilitates bond cleavage; E1-like reaction mechanism | Lys/Arg + mainchain amide + a divalent metal bound to Cys/His/Acidic residues | S00243; Phospho-2-dehydro-3-deoxyheptonate aldolase
(Catalytic domain: 3.20.20.70)
S00532; 2-dehydro-3-deoxyphosphooctonate aldolase
(Catalytic domain: 3.20.20.70)
|
5.104.2187000.9100 | Eliminative double-bond formation | Carbon (sp3) from Carbon (sp3) adjacent to double-bond | Stabilizer/Electrophile; Initial state is electrophilic anion (no need to deprotonation of deprotonation site); Electrophilic modified residue-assisted bond cleavage; Leaving group stabilized; E1cb-like reaction; mechanism | mainchain amide + MIO (Ala-Ser-Gly modified residues) | D00267; Histidine ammonia-lyase
(Catalytic domains: 1.10.275.10, 1.20.200.10)
|
5.105.3195000.7370 | Eliminative double-bond formation | Carbon (sp3) from Carboxylate (sp2) [release of CO2] | Acid/Modulator; Modulator/Organic-cofactor-assisted bond cleavage; Organic cofactor-assisted stabilization of intermediate by tautomerization; Acid protonation to eliminated group; E1 reaction mechanism | His/Ser + Thiamin diphosphate bound through calcium ion to Asp/Asn/Thr | T00230; Benzoylformate decarboxylase
(Catalytic domains: 3.40.50.970, 3.40.50.1220)
|
5.111.552000.6100 | Eliminative double-bond formation | Methylene (adjacent to double-bonded sp2 carbon ) from Carbon (sp3) (with hydroxyl group) [leading to carbonyl group] | Base-Acid; Base deprotonates dedeprotonation site leading to bond cleavage; formation of eliminated-group intermediate; Acid protonates eliminated group; E2-like reaction mechanism | An acidic residue + Lys double-bonded to substrate/intermediate | S00222; KHG/KDPG aldolase
(Catalytic domain: 3.20.20.70)
|
5.111.850000.6300 | Eliminative double-bond formation | Methylene (adjacent to double-bonded sp2 carbon ) from Carbon (sp3) (with hydroxyl group) [leading to carbonyl group] | Modulator; Substrate-assisted base deprotonates deprotonation site of leaving group through modulator; deprotonation leading to cleavage of eliminated group and double-bond formation; E2-like reaction mechanism | Tyr + Lys double-bonded to substrate/intermediate | S00200; N-acetylneuraminate lyase
(Catalytic domain: 3.20.20.70)
|
5.115.3380000.410 | Eliminative double-bond formation | Methylene (adjacent to double-bonded sp2 carbon ) from Carboxylate (sp2) [release of CO2] | Stabilizer; Inorganic cofactor-assisted stabilization of eliminated group & Leaving group stabilized; Bond-cleavage occurs by E1-like reaction mechanism | Tyr + a divalent metal ion bound to His/Asp/Lys | T00084; Phosphoenolpyruvate carboxykinase {ATP}
(Catalytic domains: 2.170.8.10, 3.40.449.10, 3.90.228.20)
|
5.115.129300.66 | Eliminative double-bond formation | Methylene (adjacent to double-bonded sp2 carbon ) from Carboxylate (sp2) [release of CO2] | Beta-ketoacyl-ACP synthase III 2nd reaction step-like mechanism | His + [Asn or Gln] | D00825; 3-oxoacyl-[acyl-carrier-protein] synthase 3
(Catalytic domain: 3.40.47.10)
D00826; 3-oxoacyl-[acyl-carrier-protein] synthase 3
(Catalytic domain: 3.40.47.10)
D00867; 3-oxoacyl-[acyl-carrier-protein] synthase 3
(Catalytic domain: 3.40.47.10)
|
5.121.670200.6100 | Eliminative double-bond formation | Carbon (sp3) (adjacent to double-bonded sp2 carbon) from Carbon (sp3) (with hydroxyl group) [leading to carbonyl group] | Base; Base deprotonation of deprotonation site of leaving group leading to bond cleavage; E2-like reaction; Substrate-assisted stabilization mechanism | An acidic residue + Lys double-bonded to substrate/intermediate | S00198; Transaldolase B
(Catalytic domain: 3.20.20.70)
|
5.121.671000.6111 | Eliminative double-bond formation | Carbon (sp3) (adjacent to double-bonded sp2 carbon) from Carbon (sp3) (with hydroxyl group) [leading to carbonyl group] | Base/Modulator; Modulator-assisted base deprotonation of deprotonation site of leaving group leading to bond cleavage; E2-like reaction mechanism | Two acidic residues + Lys double-bonded to substrate/intermediate | S00199; Fructose-bisphosphate aldolase A
(Catalytic domain: 3.20.20.70)
|
5.125.526200.114 | Eliminative double-bond formation | Carbon (sp3) (adjacent to double-bonded sp2 carbon) from Carboxylate (sp2) [release of CO2] | Modulator/Stabilizer; Stabilization of 2-bonds away from elimination site of eliminated group; E1cb-like reaction mechanism | Lys/Glu | S00826; Indole-3-glycerol phosphate synthase
(Catalytic domain: 3.20.20.70)
|
5.151.2325000.451 | Eliminative double-bond formation | Carbon (sp2) (C=C-O) from Carbon (sp3) (with hydroxyl group) [leading to carbonyl group] | Modulator-Acid/Stabilizer; Inorganic-cofactor-assisted stabilization of eliminated group; Modulator-assisted activation of eliminated group; Base deprotonation of deprotonation site of leaving group; Bond cleavage of eliminated group and double-bond formation by E2-like reaction mechanism | An acidic residue + Asn (or Gln) + zinc ion bound to His cluster | S00235; Fructose-bisphosphate aldolase class 2
(Catalytic domain: 3.20.20.70)
|
5.161.586000.968 | Eliminative double-bond formation | Carbon (sp2) (C=C-N) from Carbon (sp3) (with hydroxyl group) [leading to carbonyl group] | Base-Acid-Stabilizer;Acid-Base;Modulator; Modulator-assisted 1st base deprotonation of eliminated group & 1st acid protonation to elimination site of eliminated group leading to transition state; 2nd base deprotonation of deprotonation site leading to bond cleavage & 2nd acid protonation to eliminated group; E2-like reaction mechanism | Two acidic residues + Thr | T00089; Tryptophan synthase alpha chain
(Catalytic domains: 3.20.20.70, 3.40.50.1100)
|
5.171.2330000.7370 | Eliminative double-bond formation | Carbon (sp2) (C=N-X) from Carbon (sp3) (with hydroxyl group) [leading to carbonyl group] | Base/Modulator; Base deprotonation of deprotonation site of leaving group; Modulator/Organic-cofactor-assisted bond cleavage; E2-like reaction mechanism | His/Ser + Thiamin diphosphate bound through calcium ion to Asp/Asn/Thr | T00230; Benzoylformate decarboxylase
(Catalytic domains: 3.40.50.970, 3.40.50.1220)
|
5.191.546000.23 | Eliminative double-bond formation | Cyanide group (CN) from Carbon (sp3) (with hydroxyl group) [leading to carbonyl group] | Base/Acid-Modulator/Stabilizer/Modulator; Modulator-assisted base deprotonation of deprotonation site leading to bond cleavage; Acid protonation to eliminated group; E2-like reaction mechanism | Ser/His/Thr/Asp | S00358; Hydroxynitrilase
(Catalytic domain: 3.40.50.1820)
|
5.200.552010.6500 | Eliminative double-bond formation | Amine group from Carbon (sp3) | Base-Acid; Base deprotonates dedeprotonation site leading to bond cleavage & Acid protonates eliminated group; E2-like reaction mechanism | Lys covalently bound to substrate/intermediate | S00239; Delta-aminolevulinic acid dehydratase
(Catalytic domain: 3.20.20.70)
S00538; Delta-aminolevulinic acid dehydratase
(Catalytic domain: 3.20.20.70)
|
5.201.672500.74 | Eliminative double-bond formation | Amine group from Carbon (sp3) (with hydroxyl group) [leading to carbonyl group] | Creatinase-like elimination mechanism | His | D00244; Creatinase
(Catalytic domain: 3.90.230.10)
|
5.201.1651000.1453 | Eliminative double-bond formation | Amine group from Carbon (sp3) (with hydroxyl group) [leading to carbonyl group] | Base-Acid/Stabilizer; Inorganic-cofactor-assisted base deprotonation of deprotonation site of leaving group; Acid protonation to eliminated group; Inorganic-cofactor-assisted stabilization of intermediate; Bond cleavage of eliminated group and double-bond formation by E1cb-like reaction mechanism | Asp/Glu + two manganese ions bound to His/Asp cluster | S00419; Arginase
(Catalytic domain: 3.40.800.10)
|
5.201.1660000.464 | Eliminative double-bond formation | Amine group from Carbon (sp3) (with hydroxyl group) [leading to carbonyl group] | Base-Acid; Inorganic-cofactor-assisted base deprotonation of deprotonation site of leaving group; Acid protonation to eliminated group; Inorganic-cofactor-assisted stabilization of intermediate; Bond cleavage of eliminated group and double-bond formation by E1cb-like reaction mechanism | Glu + zinc ion bound to Cys/His cluster | D00406; Cytidine deaminase
(Catalytic domain: 3.40.140.10)
S00808; Deoxycytidylate deaminase
(Catalytic domain: 3.40.140.10)
S00810; Guanine deaminase
(Catalytic domain: 3.40.140.10)
|
5.201.2781500.453 | Eliminative double-bond formation | Amine group from Carbon (sp3) (with hydroxyl group) [leading to carbonyl group] | Adenosine deaminase 2nd reaction step-like mechanism | An acidic residue + His + zinc ion bound to His/(acidic residue) cluster | D00873; Guanine deaminase
(Catalytic domain: 3.20.20.140)
S00232; Adenosine deaminase
(Catalytic domain: 3.20.20.140)
|
5.201.2781500.563 | Eliminative double-bond formation | Amine group from Carbon (sp3) (with hydroxyl group) [leading to carbonyl group] | Adenosine deaminase 2nd reaction step-like mechanism | An acidic residue + His + Fe(II) ion bound to His/(acidic residue) cluster | D00675; Cytosine deaminase
(Catalytic domain: 3.20.20.140)
|
5.202.1504000.1 | Eliminative double-bond formation | Amine group from Carbon (sp3) (with amine group) [leading to imine group] | Acid; Interaction with enzyme and substrate/intermediate causes constraints in reactive parts & facilitates bond cleavage; protonation to eliminated group by acid through a water completes reaction; E1-like reaction mechanism | An acidic residue | S00276; Deoxycytidylate 5-hydroxymethyltransferase
(Catalytic domain: 3.30.572.10)
|
5.203.8000.93 | Eliminative double-bond formation | Amine group from Carbon (sp3) (with carboxylate group) | Base/Acid/Stabilizer/Modulator; Modulater-activated base deprotonates deprotonation site; Intermediate formation stabilized; Acid protonates eliminated group leading to cleavage; E1Cb-like reaction mechanism | His/Ser/Lys/Glu | T00094; Argininosuccinate lyase
(Catalytic domain: 1.20.200.10)
|
5.204.2187010.9090 | Eliminative double-bond formation | Amine group from Carbon (sp3) adjacent to double-bond | Stabilizer/Electrophile; Initial state is electrophilic anion (no need to deprotonation of deprotonation site); Electrophilic modified residue-assisted bond cleavage; Eliminated group stabilized; E1cb-like reaction; mechanism | Tyr/Asn/Asn + MIO (Ala-Ser-Gly modified residues) | D00267; Histidine ammonia-lyase
(Catalytic domains: 1.10.275.10, 1.20.200.10)
|
5.300.550500.6111 | Eliminative double-bond formation | Phosphate group from Carbon (sp3) | Base/Acid/Modulator; Modulator-assisted base deprotonation of deprotonation site through water leading to bond cleavage; Acid protonation to eliminated group; E2-like reaction mechanism | Two acidic residues + Lys double-bonded to substrate/intermediate | D00266; Endonuclease III
(Catalytic domains: 1.10.340.30, 1.10.1670.10)
|
5.303.667700.54 | Eliminative double-bond formation | Phosphate group from Carbon (sp3) (with carboxylate group) | Base/Stabilizer; Stabilization of eliminated group; Base deprotonation of deprotonation site of leaving group leading to bond cleavage; E2-like reaction mechanism | Cys + Arg/Lys cluster | D00415; UDP-N-acetylglucosamine 1-carboxyvinyltransferase
(Catalytic domain: 3.65.10.10)
|
5.304.3380000.2135 | Eliminative double-bond formation | Phosphate group from Carbon (sp3) adjacent to double-bond | Stabilizer; Inorganic cofactor-assisted stabilization of eliminated group & Leaving group stabilized; Bond-cleavage occurs by E1-like reaction mechanism | Lys/Arg cluster + Thr/Gln + mainchain carbonyl + three magnesium ions bound to acidic residues | S00024; Farnesyl pyrophosphate synthetase
(Catalytic domain: 1.10.600.10)
|
5.305.2200100.675 | Eliminative double-bond formation | Phosphate group from Carboxylate (sp2) [release of CO2] | Base-Acid/Stabilizer; Base deprotonation of deprotonation site of leaving group; Bond cleavage of eliminated group and double-bond formation by E2-like reaction; Inorganic-cofactor-assisted stabilization of eliminated intermediate: Acid protonation to eliminated intermediate mechanism | His/Arg + hydrophobic residues + divalent metal ion bound to acidic residues | T00217; Phosphoenolpyruvate carboxylase
(Catalytic domains: 1.20.1100.10, 3.20.20.60)
|
5.501.400060.67 | Eliminative double-bond formation | Sulfide from Carbon (sp3) (with hydroxyl group) [leading to carbonyl group] | HMG-CoA reductase class II 2nd reaction step-like mechanism | His/Lys + two acidic residues | D00607; 3-hydroxy-3-methylglutaryl-coenzyme A reductase
(Catalytic domain: 3.90.770.10)
M00180; 3-hydroxy-3-methylglutaryl-coenzyme A reductase
(Catalytic domains: 3.30.70.420, 3.90.770.10)
|
5.524.3198500.5541 | Eliminative double-bond formation | Sulfoxide group from Carbon (sp3) adjacent to double-bond | Allinase 3rd reaction step-like mechanism | Lys + an acidic residue + Tyr/Tyr + hydroxyl residue (Ser or Thr) + mainchain amide + PLP covalently bound to substrate/intermediate | T00407; Alliin lyase 1
(Catalytic domains: 2.10.25.30, 3.40.640.10)
|
5.1020.2074300.8301 | Eliminative double-bond formation | O-glycoside group from Carbon (sp3) adjacent to double-bond: Non-beta elimination | 6-phospho-alpha-glucosidase 3rd reaction step-like mechanism | An acidic residue + manganese ion bound to Cys/His/O7-nicotinamide/substrate or intermediate | D00827; Maltose-6''-phosphate glucosidase
(Catalytic domain: 3.90.110.10)
|
5.1202.1504200.6501 | Eliminative double-bond formation | Amine group from Carbon (sp3) adjacent to double-bond with amine group [leading to imine group]: Non-beta elimination | Acid; Electrophilic leaving group; Acid protonation to eliminated group completes reaction; E1-like reaction mechanism | Lys + Lys covalently bound to substrate/intermediate | S00239; Delta-aminolevulinic acid dehydratase
(Catalytic domain: 3.20.20.70)
S00538; Delta-aminolevulinic acid dehydratase
(Catalytic domain: 3.20.20.70)
|
5.1204.671000.4100 | Eliminative double-bond formation | Amine group from Carbon (sp3) adjacent to double-bond: Non-beta elimination | Base/Modulator; Modulator-assisted base deprotonation of deprotonation site of leaving group leading to bond cleavage; E2-like reaction mechanism | Two acidic residues + Cys covalently bound to substrate/intermediate | S00276; Deoxycytidylate 5-hydroxymethyltransferase
(Catalytic domain: 3.30.572.10)
|
5.1304.666000.68 | Eliminative double-bond formation | Phosphate group from Carbon (sp3) adjacent to double-bond: Non-beta elimination | Base/Modulator/Stabilizers; Modulator-activated base deprotonates deprotonation site leading to bond cleavage; Eliminated group & leaving group stabilized; E2-like reaction mechanism | Asp/Asp/His/His + Lys + Thr/Ser cluster + mainchain amide | S00370; Methylglyoxal synthase
(Catalytic domain: 3.40.50.1380)
|
5.1304.3086000.333 | Eliminative double-bond formation | Phosphate group from Carbon (sp3) adjacent to double-bond: Non-beta elimination | Stabilizer; Inorganic cofactor-assisted stabilization of eliminated group; Bond-cleavage occurs by E1-like reaction; Intermediate formation; Substrate-assisted base deprotonation of deprotonation site of leaving group mechanism | Arg/Lys cluster + Gln/Ser + magnesium ion bound to acidic residues | S00220; Thiamine-phosphate pyrophosphorylase
(Catalytic domain: 3.20.20.70)
|
5.1504.667700.4100 | Eliminative double-bond formation | Sulfide from Carbon (sp3) adjacent to double-bond: Non-beta elimination | Base/Stabilizer; Stabilization of eliminated group; Base deprotonation of deprotonation site of leaving group leading to bond cleavage; E2-like reaction mechanism | Glu/Arg + mainchain carbonyl + Cys covalently bound to substrate/intermediate | D00082; Modification methylase HaeIII
(Catalytic domain: 3.40.50.150)
|
6.10.82600.5900 | Exchange of double-bonded atoms | Carbonyl oxygen to Schiff-base nitrogen (Schiff-base formation; dehydration) | Acid-Base-Acid/Modulator; Substituted group attacks on double-bond partner atom; Acid protonation to leaving group; Formation of tetrahedral intermediate; Base deprotonation of substituted group; Lone pair on nucleophile attacks again on double-bond partner atom & 2nd Acid protonation to leaving group; Organic-cofactor-assisted reaction mechanism | Lys/Tyr + PMP bound | D00101; Aspartate aminotransferase
(Catalytic domain: 3.40.640.10)
D00102; Tyrosine aminotransferase
(Catalytic domain: 3.40.640.10)
D00108; Aromatic-amino-acid aminotransferase
(Catalytic domain: 3.40.640.10)
|
6.10.85210.5901 | Exchange of double-bonded atoms | Carbonyl oxygen to Schiff-base nitrogen (Schiff-base formation; dehydration) | Base/Acid/Modulator; Base-activated substituted group attacks on double-bond partner atom; Acid protonation to leaving group; Formation of tetrahedral intermediate; 2nd base deprotonation of substituted group; Lone pair on nucleophile attacks again on double-bond partner atom; Proton transfer from protonated base to deprotonated acid through cofactor/modulator and water; Organic-cofactor-assisted reaction mechanism | Lys/His/Tyr + PMP bound | D00105; D-alanine aminotransferase
(Catalytic domains: 3.20.10.10, 3.30.470.10)
|
6.10.398000.111 | Exchange of double-bonded atoms | Carbonyl oxygen to Schiff-base nitrogen (Schiff-base formation; dehydration) | Nucleophile/Acid-Base-Modulator-Stabilizer; Modulator-assisted nucleophile attacks on double-bond partner atom; Formation of tetrahedral transition-state; Transition-state stabilized; 1st general acid protonates tetrahedral transition-state; Base deprotonates 2nd Nucleophile; Lone-pair of 2nd Nucleophile attacks on center atom of tetrahedral intermediate; 2nd acid protonates leaving group leading to elimination of leaving group; SN2 & E2 mechanism | Lys/Lys | S00239; Delta-aminolevulinic acid dehydratase
(Catalytic domain: 3.20.20.70)
S00537; Delta-aminolevulinic acid dehydratase
(Catalytic domain: 3.20.20.70)
S00538; Delta-aminolevulinic acid dehydratase
(Catalytic domain: 3.20.20.70)
S00539; Delta-aminolevulinic acid dehydratase
(Catalytic domain: 3.20.20.70)
|
6.10.400000.116 | Exchange of double-bonded atoms | Carbonyl oxygen to Schiff-base nitrogen (Schiff-base formation; dehydration) | Nucleophile/Base-Acid/Stabilizer-Modulator; Base activation of nucleophile through a modulated water; activated nucleophile attacks on double-bond partner atom; Stabilization of tetrahedral intermediate; Proton transfer from Nucleophile to leaving group through water; Acid protonation to leaving group mechanism | Lys/Glu/Thr | S00198; Transaldolase B
(Catalytic domain: 3.20.20.70)
|
6.10.400200.114 | Exchange of double-bonded atoms | Carbonyl oxygen to Schiff-base nitrogen (Schiff-base formation; dehydration) | Nucleophile-Acid/Base-Acid-Stabilizer; Base-activated nucleophile attacks on double-bond partner atom; Formation of tetrahedral intermediate; Nucleophile also acts as 1st general acid to protonate leaving group; 2nd Acid protonates leaving group mechanism | Lys/Glu | S00222; KHG/KDPG aldolase
(Catalytic domain: 3.20.20.70)
|
6.10.400600.113 | Exchange of double-bonded atoms | Carbonyl oxygen to Schiff-base nitrogen (Schiff-base formation; dehydration) | Nucleophile/Base-Acid/Modulator; Modulator-assisted base activation of nucleophile; nucleophile attacks on double-bonded partner atom; Acid-Base transfers proton from the nucleophile to leaving group; Acid protonation to leaving group completing reaction mechanism | Lys + two acidic residues | S00199; Fructose-bisphosphate aldolase A
(Catalytic domain: 3.20.20.70)
|
6.10.431300.120 | Exchange of double-bonded atoms | Carbonyl oxygen to Schiff-base nitrogen (Schiff-base formation; dehydration) | Nucleophile/Substrate-assisted-Acid-Base-Stabilizer; nucleophile attacks on double-bond partner atom; Formation of tetrahedral transition-state; Transition-state stabilized; 1st substrate-acid protonates tetrahedral transition-state; Substrate-base deprotonates 2nd Nucleophile; Lone-pair of 2nd Nucleophile attacks on center atom of tetrahedral intermediate; 2nd substrate-acid protonates leaving group leading to elimination of leaving group; SN2 & E2 mechanism | Lys | S00239; Delta-aminolevulinic acid dehydratase
(Catalytic domain: 3.20.20.70)
S00537; Delta-aminolevulinic acid dehydratase
(Catalytic domain: 3.20.20.70)
S00538; Delta-aminolevulinic acid dehydratase
(Catalytic domain: 3.20.20.70)
S00539; Delta-aminolevulinic acid dehydratase
(Catalytic domain: 3.20.20.70)
|
6.10.445000.115 | Exchange of double-bonded atoms | Carbonyl oxygen to Schiff-base nitrogen (Schiff-base formation; dehydration) | Nucleophile-Acid/Stabilizer; Nucleophile attacks on double-bond partner atom; Formation of tetrahedral intermediate; Nucleophile also acts as 1st general acid to protonate leaving group; Same acid protonates leaving group leading to elimination of leaving group; Indirect stabilization mechanism | Lys + mainchain carbonyl | S00200; N-acetylneuraminate lyase
(Catalytic domain: 3.20.20.70)
|
6.10.448000.112 | Exchange of double-bonded atoms | Carbonyl oxygen to Schiff-base nitrogen (Schiff-base formation; dehydration) | Nucleophile-Acid/Acid/Modulator; Nucleophile attacks on double-bond partner atom; Formation of tetrahedral intermediate; Nucleophile also acts as 1st general acid to protonate leaving group; A second acid protonates leaving group leading to elimination of leaving group mechanism | Lys/His/Glu | S00240; 3-dehydroquinate dehydratase
(Catalytic domain: 3.20.20.70)
|
6.20.7100.6120 | Exchange of double-bonded atoms | Schiff-base nitrogen to Carbonyl oxygen (Schiff-base deformation; hydration) | Base-Acid/Stabilizer-Modulator; Base activation of substituted group through a water; substituted group attacks on double-bonded partner atom; Stabilization of tetrahedral intermediate; Proton transfer from the substituted group to leaving group through water; Acid protonation to leaving group mechanism | Glu/Thr + Lys double-bonded to substrate/intermediate | S00198; Transaldolase B
(Catalytic domain: 3.20.20.70)
|
6.20.7800.6111 | Exchange of double-bonded atoms | Schiff-base nitrogen to Carbonyl oxygen (Schiff-base deformation; hydration) | Base-Acid/Modulator; Modulator-assisted base activation of substituted group; substituted group attacks on double-bonded partner atom; Acid-Base transfers proton from the substituted group to leaving group; Acid protonation to leaving group mechanism | Two acidic residues + Lys double-bonded to substrate/intermediate | S00199; Fructose-bisphosphate aldolase A
(Catalytic domain: 3.20.20.70)
|
6.20.8000.6100 | Exchange of double-bonded atoms | Schiff-base nitrogen to Carbonyl oxygen (Schiff-base deformation; hydration) | Base-Acid/Base; Base activation of substituted group; Substituted group attacks on double-bond partner atom; Formation of tetrahedral intermediate; Covalently-bonded base deprotonates substituted group; Lone pair on substituted group attacks again on double-bond partner atom leading to bond cleavage; Acid protonation to leaving group mechanism | An acidic residue + Lys double-bonded to substrate/intermediate | S00222; KHG/KDPG aldolase
(Catalytic domain: 3.20.20.70)
|
6.20.8010.6100 | Exchange of double-bonded atoms | Schiff-base nitrogen to Carbonyl oxygen (Schiff-base deformation; hydration) | Base-Acid; Base activation of substituted group; substituted group attacks on double-bonded partner atom; Acid-Base transfers proton from the substituted group to leaving group; Acid protonation to leaving group mechanism | An acidic residue + Lys double-bonded to substrate/intermediate | D00266; Endonuclease III
(Catalytic domains: 1.10.340.30, 1.10.1670.10)
|
6.20.28500.6010 | Exchange of double-bonded atoms | Schiff-base nitrogen to Carbonyl oxygen (Schiff-base deformation; hydration) | Base/Modulator/Base; Base activation of substituted group; Substituted group attacks on double-bond partner atom; Formation of tetrahedral intermediate; Covalently-bonded base deprotonates substituted group; Lone pair on nucleophile (substituted group) attacks again on double-bond partner atom mechanism | His/Glu + Lys double-bonded to substrate/intermediate | S00240; 3-dehydroquinate dehydratase
(Catalytic domain: 3.20.20.70)
|
6.20.29000.6000 | Exchange of double-bonded atoms | Schiff-base nitrogen to Carbonyl oxygen (Schiff-base deformation; hydration) | Base; Substituted group attacks on double-bond partner atom; Formation of tetrahedral intermediate; Covalently-bonded base deprotonates substituted group; Lone pair on nucleophile attacks again on double-bond partner atom mechanism | Lys double-bonded to substrate/intermediate | S00200; N-acetylneuraminate lyase
(Catalytic domain: 3.20.20.70)
|
6.20.85200.5520 | Exchange of double-bonded atoms | Schiff-base nitrogen to Carbonyl oxygen (Schiff-base deformation; hydration) | Base-Acid-Base/Modulator; Base-activated substituted group attacks on double-bond partner atom; Acid protonation to leaving group; Formation of tetrahedral intermediate; 2nd base deprotonation of substituted group; Lone pair on nucleophile attacks again on double-bond partner atom; Organic-cofactor-assisted reaction mechanism | Lys/Tyr + PLP double-bonded to substrate/intermediate | D00101; Aspartate aminotransferase
(Catalytic domain: 3.40.640.10)
D00102; Tyrosine aminotransferase
(Catalytic domain: 3.40.640.10)
D00108; Aromatic-amino-acid aminotransferase
(Catalytic domain: 3.40.640.10)
|
6.20.85210.5511 | Exchange of double-bonded atoms | Schiff-base nitrogen to Carbonyl oxygen (Schiff-base deformation; hydration) | Base/Acid/Modulator; Base-activated substituted group attacks on double-bond partner atom; Acid protonation to leaving group; Formation of tetrahedral intermediate; 2nd base deprotonation of substituted group; Lone pair on nucleophile attacks again on double-bond partner atom; Proton transfer from protonated base to deprotonated acid through cofactor/modulator and water; Organic-cofactor-assisted reaction mechanism | His/Lys/Tyr + PLP double-bonded to substrate/intermediate | D00105; D-alanine aminotransferase
(Catalytic domains: 3.20.10.10, 3.30.470.10)
|
6.20.93000.5520 | Exchange of double-bonded atoms | Schiff-base nitrogen to Carbonyl oxygen (Schiff-base deformation; hydration) | Base/Modulator; Base-activated substituted group attacks on double-bond partner atom; Formation of tetrahedral intermediate; Organic-cofactor-assisted deprotonation of 3rd base; 3rd base activation of lone pair on nucleophile; Lone pair on nucleophile attacks again on doulbe-bond partner atom; Organic-cofactor-assisted protonation to leaving group mechanism | Lys/Tyr + PLP double-bonded to substrate/intermediate | D00106; Branched-chain-amino-acid aminotransferase
(Catalytic domain: 3.20.10.10)
|
6.30.83700.5070 | Exchange of double-bonded atoms | Exchange of Schiff-base nitrogen atoms (external aldimine formation) | Base-Acid-Base; Base-activated substituted group attacks on double-bond partner atom; Acid protonation to leaving group; Formation of tetrahedral intermediate; 2nd base deprotonation of substituted group; Lone pair on nucleophile attacks again on double-bond partner atom; Organic-cofactor-assisted reaction mechanism | An acidic residue + PLP double-bonded to Lys | T00089; Tryptophan synthase alpha chain
(Catalytic domains: 3.20.20.70, 3.40.50.1100)
|
6.30.93020.5311 | Exchange of double-bonded atoms | Exchange of Schiff-base nitrogen atoms (external aldimine formation) | Base/Modulator; Modulator-assisted base activation of substituted group attacks on double-bond partner atom; Formation of tetrahedral intermediate; Organic-cofactor-assisted deprotonation of nucleophile & protonation to leaving group; Lone pair on nucleophile attacks again on doulbe-bond partner atom mechanism | Tyr +Arg/His/Asp + PLP double-bonded to Lys | D00271; Alanine racemase
(Catalytic domains: 2.40.37.10, 3.20.20.10)
|
6.30.97700.5320 | Exchange of double-bonded atoms | Exchange of Schiff-base nitrogen atoms (external aldimine formation) | Base/Modulator; Organic-cofactor/Modulator-assisted proton transfer from substituted group to leaving group; Nucleophilic attack of substituted group on double-bond partner atom; Formation of tetrahedral intermediate; Lone pair on nucleophile attacks again on double-bond partner atom mechanism | Tyr/Tyr + PLP double-bonded to Lys | D00101; Aspartate aminotransferase
(Catalytic domain: 3.40.640.10)
D00102; Tyrosine aminotransferase
(Catalytic domain: 3.40.640.10)
D00108; Aromatic-amino-acid aminotransferase
(Catalytic domain: 3.40.640.10)
T00407; Alliin lyase 1
(Catalytic domains: 2.10.25.30, 3.40.640.10)
|
6.30.97710.5300 | Exchange of double-bonded atoms | Exchange of Schiff-base nitrogen atoms (external aldimine formation) | Base/Modulator; Organic-cofactor/Modulator-assisted proton transfer from substituted group to leaving group through water; Nucleophilic attack of substituted group on double-bond partner atom; Formation of tetrahedral intermediate; Lone pair on nucleophile attacks again on double-bond partner atom mechanism | Tyr + PLP double-bonded to Lys | D00105; D-alanine aminotransferase
(Catalytic domains: 3.20.10.10, 3.30.470.10)
|
6.30.100000.5310 | Exchange of double-bonded atoms | Exchange of Schiff-base nitrogen atoms (external aldimine formation) | Base/Modulator; Base-activated substituted group attacks on double-bond partner atom; Formation of tetrahedral intermediate; Lone pair on nucleophile attacks again on double-bond partner atom; Organic-cofactor-assisted reaction mechanism | Tyr/Arg + PLP double-bonded to Lys | D00265; Cystathionine gamma-synthase
(Catalytic domain: 3.40.640.10)
|
6.30.115000.5080 | Exchange of double-bonded atoms | Exchange of Schiff-base nitrogen atoms (external aldimine formation) | Base/Modulator; Cofactor-assisted activation of substituted group; Activated substituted group attacks on double-bond partner atom; Formation of tetrahedral intermediate; Base-activation of nucleophile; Lone pair on nucleophile attacks again on double-bond partner atom mechanism | His + His/Ser + an acidic residue + PLP double-bonded to Lys | D00092; 8-amino-7-oxononanoate synthase
(Catalytic domains: 3.40.640.10, 3.90.1150.10)
D00639; 2-amino-3-ketobutyrate coenzyme A ligase
(Catalytic domain: 3.40.640.10)
|
6.30.115020.5300 | Exchange of double-bonded atoms | Exchange of Schiff-base nitrogen atoms (external aldimine formation) | Modulator; Oraganic-cofactor/substrate-assisted activation of substituted group; Activated substituted group attacks on double-bond partner atom; Formation of tetrahedral intermediate; Cofactor-assisted activation of nucleophile; Lone pair on nucleophile attacks again on doulbe-bond partner atom mechanism | Tyr + PLP double-bonded to Lys | D00106; Branched-chain-amino-acid aminotransferase
(Catalytic domain: 3.20.10.10)
|
6.30.264850.5200 | Exchange of double-bonded atoms | Exchange of Schiff-base nitrogen atoms (external aldimine formation) | Modulator; Oraganic-cofactor/substrate-assisted activation of substituted group; Activated substituted group attacks on double-bond partner atom; Formation of tetrahedral intermediate; Modulator/Cofactor-assisted activation of nucleophile; Lone pair on nucleophile attacks again on double-bond partner atom mechanism | Hydroxyl residue (Thr or Ser) + PLP double-bonded to Lys | D00085; Serine hydroxymethyltransferase
(Catalytic domain: 3.40.640.10)
|
6.40.477300.5510 | Exchange of double-bonded atoms | Exchange of Schiff-base nitrogen atoms (internal aldimine formation) | Nucleophile/Base-Acid-Base; Base-activated nucleophile attacks on double-bond partner atom; Acid protonation to leaving group; Formation of tetrahedral intermediate; 2nd base deprotonation of nucleophile; Lone pair on nucleophile attacks again on double-bond partner atom; Organic-cofactor-assisted reaction mechanism | Lys/His + PLP double-bonded to substrate/intermediate | T00089; Tryptophan synthase alpha chain
(Catalytic domains: 3.20.20.70, 3.40.50.1100)
|
6.40.500000.5600 | Exchange of double-bonded atoms | Exchange of Schiff-base nitrogen atoms (internal aldimine formation) | Nucleophile/Acid/Modulator; Nucleophile attacks on double-bond partner atom; Formation of tetrahedral intermediate; protonation to leaving group; Organic-cofactor-assisted activation of nucleophile; Lone pair on nucleophile attacks on double-bond partner atom mechanism | Lys/His + His/Ser + an acidic residue + PLP double-bonded to substrate/intermediate | D00639; 2-amino-3-ketobutyrate coenzyme A ligase
(Catalytic domain: 3.40.640.10)
|
6.40.508000.5522 | Exchange of double-bonded atoms | Exchange of Schiff-base nitrogen atoms (internal aldimine formation) | Nucleophile/Acid/Modulator; Nucleophile attacks on double-bond partner atom; Formation of tetrahedral intermediate; Organic-cofactor-assisted protonation to leaving group & deprotonation of nucleophile; Lone pair on nucleophile attacks on double-bond partner atom mechanism | Lys/Tyr +Arg/His/Asp + PLP double-bonded to substrate/intermediate | D00271; Alanine racemase
(Catalytic domains: 2.40.37.10, 3.20.20.10)
|
6.40.521000.5530 | Exchange of double-bonded atoms | Exchange of Schiff-base nitrogen atoms (internal aldimine formation) | Nucleophile/Acid/Modulator; Nucleophile attacks on double-bond partner atom; Acid protonation to leaving group; Formation of tetrahedral intermediate; Lone pair on nucleophile attacks on double-bond partner atom; Organic-cofactor/Modulator-assisted proton transfer from nucleophile to leaving group mechanism | Lys/Tyr/Tyr + PLP double-bonded to substrate/intermediate | D00101; Aspartate aminotransferase
(Catalytic domain: 3.40.640.10)
D00102; Tyrosine aminotransferase
(Catalytic domain: 3.40.640.10)
D00108; Aromatic-amino-acid aminotransferase
(Catalytic domain: 3.40.640.10)
T00407; Alliin lyase 1
(Catalytic domains: 2.10.25.30, 3.40.640.10)
|
6.40.521010.5520 | Exchange of double-bonded atoms | Exchange of Schiff-base nitrogen atoms (internal aldimine formation) | Nucleophile-Acid/Modulator; Nucleophile attacks on double-bond partner atom; Acid protonation to leaving group through water; Formation of tetrahedral intermediate; Lone pair on nucleophile attacks on double-bond partner atom; Organic-cofactor/Modulator-assisted proton transfer from nucleophile to leaving group through water mechanism | Lys/Tyr + PLP double-bonded to substrate/intermediate | D00105; D-alanine aminotransferase
(Catalytic domains: 3.20.10.10, 3.30.470.10)
|
6.40.528600.5540 | Exchange of double-bonded atoms | Exchange of Schiff-base nitrogen atoms (internal aldimine formation) | Nucleophile/Modulator; Modulator-assisted nucleophile attacks on double-bond partner atom; Formation of tetrahedral intermediate; Organic-cofactor-assisted proton transfer between nucleophile and leaving group; Lone pair on nucleophile attacks on double-bond partner atom; substrate-assisted protonation to leaving group mechanism | Lys + hydroxyl residue (Thr or Ser) + PLP double-bonded to substrate/intermediate | D00085; Serine hydroxymethyltransferase
(Catalytic domain: 3.40.640.10)
|
8.112.3600000.6580 | Isomerization | Adjacent bond; C=C-N to C-C=N | Acid/Stabilizer/Nucleophile; lone pair at nucleophile attacks on central atom; Intermediate stabilized; Acid protonation to initially-double-bonded atom mechanism | Asp/Lys + Lys covalently bound to substrate/intermediate | S00199; Fructose-bisphosphate aldolase A
(Catalytic domain: 3.20.20.70)
|
8.113.42001.5 | Isomerization | Adjacent bond; C=C-O to C-C=O | Base-Acid/Stabilizers; Base deprotonation of initially single-bonded atom leading to intermediate formation; Intermediate stabilized; Acid protonation to initially double-bonded atom mechanism | An acidic residue + His/Asn | S00225; Triosephosphate isomerase
(Catalytic domain: 3.20.20.70)
T00239; Bifunctional PGK/TIM
(Catalytic domains: 3.20.20.70, 3.40.50.1260, 3.40.50.1270)
|
8.113.46500.4 | Isomerization | Adjacent bond; C=C-O to C-C=O | Metal-independent eukaryotic CMLE-like mechanism | An acidic residue + His | S00852; Carboxy-cis,cis-muconate cyclase
(Catalytic domain: 2.130.10.10)
|
8.113.46500.7 | Isomerization | Adjacent bond; C=C-O to C-C=O | Metal-independent eukaryotic CMLE-like mechanism | An acidic residue + Lys | T00201; Glucosamine--fructose-6-phosphate aminotransferase {isomerizing}
(Catalytic domains: 3.40.50.10490, 3.60.20.10)
|
8.113.365000.100 | Isomerization | Adjacent bond; C=C-O to C-C=O | Acid/Modulator; Modulator-assisted acid protonation to initially-double-bonded atom; water molecules required for proton shuttle to recover catalytic residues mechanism | Tyr/Asn | S00155; dTDP-4-dehydrorhamnose 3,5-epimerase
(Catalytic domain: 2.60.120.10)
|
8.113.365001.100 | Isomerization | Adjacent bond; C=C-O to C-C=O | Acid/Modulator; Modulator-assisted acid protonation to initially-double-bonded atom through a water; water molecules required for proton shuttle to recover catalytic residues mechanism | Tyr/Asn | S00155; dTDP-4-dehydrorhamnose 3,5-epimerase
(Catalytic domain: 2.60.120.10)
|
8.113.580000.386 | Isomerization | Adjacent bond; C=C-O to C-C=O | Base-Stabilizer/Acid/Modulator/Stabilizer; Inorganic cofactor-assisted stabilization of adjacent atoms of central atom/initially single-bonded atom/double-bonded atom; Modulator-assisted acid protonation to initially double-bonded atom & Base deprotonation of initially single-bonded atom mechanism | His/Glu/Asp + Lys + magnesium ion bound to acidic residues | D00273; Mandelate racemase
(Catalytic domain: 3.20.20.120)
|
8.113.585900.479 | Isomerization | Adjacent bond; C=C-O to C-C=O | Acid-Base/Acid; Inorganic-cofactor-assisted stabilization of initially single-bonded atom and adjacent atom to double-bonded atom; Acid protonation to double-bonded atom & Base deprotonation of single-bonded atom; 2nd Acid protonation to adjacent atom to initially-double-bonded atom mechanism | Two acidic residues + zinc ion bound to Gln/His/Glu & substrate/intermediate | S00185; Lactoylglutathione lyase
(Catalytic domain: 3.10.180.10)
|
8.113.585900.720 | Isomerization | Adjacent bond; C=C-O to C-C=O | Acid-Base/Acid; Inorganic-cofactor-assisted stabilization of initially single-bonded atom and adjacent atom to double-bonded atom; Acid protonation to double-bonded atom & Base deprotonation of single-bonded atom; 2nd Acid protonation to adjacent atom to initially-double-bonded atom mechanism | Two acidic residues + nickel ion bound to His/Glu cluster & substrate/intermediate | S00540; Glyoxylase family protein
(Catalytic domain: 3.10.180.10)
|
8.113.594730.651 | Isomerization | Adjacent bond; C=C-O to C-C=O | Metal-dependent bacterial MLE-like mechanism | An acidic residue + Lys/Lys + manganese ion bound to acidic residues | D00282; Muconate cycloisomerase 1
(Catalytic domain: 3.20.20.120)
D00283; Chloromuconate cycloisomerase
(Catalytic domain: 3.20.20.120)
|
8.113.901890.372 | Isomerization | Adjacent bond; C=C-O to C-C=O | Glucarate dehydratase 3rd reaction step-like mechanism | His + Tyr/Lys/Asn + magnesium ion bound to Asp/Glu/Asn | D00261; Glucarate dehydratase
(Catalytic domain: 3.20.20.120)
|
8.113.904850.8015 | Isomerization | Adjacent bond; C=C-O to C-C=O | 6-phospho-alpha-glucosidase 5th reaction step-like mechanism | Tyr + Glu + manganese ion bound to Cys/His/O7-nicotinamide/substrate or intermediate | D00827; Maltose-6''-phosphate glucosidase
(Catalytic domain: 3.90.110.10)
|
8.113.904870.263 | Isomerization | Adjacent bond; C=C-O to C-C=O | Mannose-6-phosphate isomerase 2nd reaction step-like mechanism | Glu/Tyr + zinc ion bound to His/Glu/Gln cluster | T00101; Mannose-6-phosphate isomerase
(Catalytic domain: 2.60.120.10)
|
8.113.915300.451 | Isomerization | Adjacent bond; C=C-O to C-C=O | Acid/Stabilizer; Inorganic-cofactor-assisted stabilization of initially single-bonded atom; Acid protonation to double-bonded atom mechanism | An acidic residue + Asn (or Gln) + zinc ion bound to His cluster | S00235; Fructose-bisphosphate aldolase class 2
(Catalytic domain: 3.20.20.70)
|
8.113.915310.365 | Isomerization | Adjacent bond; C=C-O to C-C=O | Acid/Proton_shuttle/Stabilizer; Inorganic-cofactor-assisted stabilization of initially single-bonded atom; Acid protonation to double-bonded atom through proton-shuttle mechanism | Glu + Thr/Ser + Lys + magnesium ion bound to acidic residues | T00043; Pyruvate kinase I
(Catalytic domains: 2.40.33.10, 3.20.20.60)
|
8.113.919760.1180 | Isomerization | Adjacent bond; C=C-O to C-C=O | Acid; Inorganic-cofactor-assisted stabilization of initially single-bonded atom; Acid protonation to double-bonded atom mechanism | Lys + two magnesium ions bound to acidic residues | S00841; Phosphosulfolactate synthase
(Catalytic domain: 3.20.20.70)
|
8.113.1441400.8202 | Isomerization | Adjacent bond; C=C-O to C-C=O | GDP fucose synthase 2nd reaction step-like mechanism | His + Tyr/Lys bound to ribose-nicotinamide | D00604; GDP-L-fucose synthetase
(Catalytic domains: 3.40.50.720, 3.90.25.10)
|
8.121.42000.7 | Isomerization | Adjacent bond; N=C-C to N-C=C | Base/Acid-Stabilizer; Base deprotonation of initially single-bonded atom leading to intermediate formation; Intermediate stabilized; Acid protonation to initially double-bonded atom mechanism | An acidic residue + Lys | T00201; Glucosamine--fructose-6-phosphate aminotransferase {isomerizing}
(Catalytic domains: 3.40.50.10490, 3.60.20.10)
|
8.121.166300.1 | Isomerization | Adjacent bond; N=C-C to N-C=C | Base; Base deprotonation of initially-single-bonded atom completes reaction mechanism | An acidic residue | S00226; 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
(Catalytic domain: 3.20.20.70)
|
8.121.166300.8 | Isomerization | Adjacent bond; N=C-C to N-C=C | Base; Base deprotonation of initially-single-bonded atom completes reaction mechanism | Cys | S00847; N-(5''-phosphoribosyl)anthranilate isomerase
(Catalytic domain: 3.20.20.70)
|
8.121.1440000.6450 | Isomerization | Adjacent bond; N=C-C to N-C=C | Inorganic-cofactor-assisted base; Base bound to inroganic-cofactor deprotonation of originally single-bonded atom leading to isomerization mechanism | Hydroxide bound to Zinc bound to Cys cluster + Lys double-bonded to substrate/intermediate | S00239; Delta-aminolevulinic acid dehydratase
(Catalytic domain: 3.20.20.70)
S00538; Delta-aminolevulinic acid dehydratase
(Catalytic domain: 3.20.20.70)
|
8.131.42001.6 | Isomerization | Adjacent bond; O=C-C to O-C=C | Base-Acid/Stabilizers; Base deprotonation of initially single-bonded atom leading to intermediate formation; Intermediate stabilized; Acid protonation to initially double-bonded atom mechanism | An acidic residue + His/Lys | S00225; Triosephosphate isomerase
(Catalytic domain: 3.20.20.70)
T00239; Bifunctional PGK/TIM
(Catalytic domains: 3.20.20.70, 3.40.50.1260, 3.40.50.1270)
|
8.131.160500.80 | Isomerization | Adjacent bond; O=C-C to O-C=C | Base/Modulator/Stabilizer; Modulator-assisted base deprotonation of initially-single-bonded atom; Initially-double-bonded atom stabilized mechanism | His/Asp/Lys | S00155; dTDP-4-dehydrorhamnose 3,5-epimerase
(Catalytic domain: 2.60.120.10)
|
8.131.161950.140 | Isomerization | Adjacent bond; O=C-C to O-C=C | Dodecenoyl-CoA delta-isomerase 1st reaction step-like mechanism | An acidic residue + mainchain amide groups | S00849; 3,2-trans-enoyl-CoA isomerase (EC 5.3.3.8) (Dodecenoyl-CoA isomerase) (Delta
(Catalytic domain: 3.90.226.10)
|
8.131.164850.131 | Isomerization | Adjacent bond; O=C-C to O-C=C | GDP mannose dehydratase 2nd reaction step-like mechanism | An acidic residue + Arg | D00513; GDP-mannose 4,6 dehydratase 2
(Catalytic domains: 3.40.50.720, 3.90.25.10)
D00543; GDP-mannose 4,6-dehydratase
(Catalytic domains: 3.40.50.720, 3.90.25.10)
|
8.131.581400.399 | Isomerization | Adjacent bond; O=C-C to O-C=C | Base/Acid-Stabilizer/Stabilizer; Inorganic cofactor-assisted stabilization of adjacent atoms of central atom/initially single-bonded atom/double-bonded atom; Base deprotonation of initially single-bonded atom & Acid protonation to initially double-bonded atom mechanism | Lys/Glu + Lys + magnesium ion bound to acidic residues | D00273; Mandelate racemase
(Catalytic domain: 3.20.20.120)
|
8.131.584400.264 | Isomerization | Adjacent bond; O=C-C to O-C=C | Base/Base-Acid/Modulator; Modulator-assisted base deprotonation of initially single-bonded atom; Inorganic cofactor-assisted proton transfer by base-acid from atom adjacent to initially single-bonded atom to initially double-bonded atom mechanism | Glu/Lys/Tyr + zinc ion bound to His/Glu/Gln cluster | T00101; Mannose-6-phosphate isomerase
(Catalytic domain: 2.60.120.10)
|
8.131.704320.8015 | Isomerization | Adjacent bond; O=C-C to O-C=C | 6-phospho-alpha-glucosidase 2nd reaction step-like mechanism | Tyr + Glu + manganese ion bound to Cys/His/O7-nicotinamide/substrate or intermediate | D00827; Maltose-6''-phosphate glucosidase
(Catalytic domain: 3.90.110.10)
|
8.131.705800.452 | Isomerization | Adjacent bond; O=C-C to O-C=C | Base; Inorganic-cofactor-assisted stabilization of double-bonded atom and adjacent atom to single-bonded atom; Inorganic-cofactor-assisted activation of initially single-bonded atom; Base deprotonation of single-bonded atom mechanism | An acidic residue + zinc ion bound to Gln/His/Glu & substrate/intermediate | S00185; Lactoylglutathione lyase
(Catalytic domain: 3.10.180.10)
|
8.131.705800.710 | Isomerization | Adjacent bond; O=C-C to O-C=C | Base; Inorganic-cofactor-assisted stabilization of double-bonded atom and adjacent atom to single-bonded atom; Inorganic-cofactor-assisted activation of initially single-bonded atom; Base deprotonation of single-bonded atom mechanism | An acidic residue + nickel ion bound to His/Glu cluster & substrate/intermediate | S00540; Glyoxylase family protein
(Catalytic domain: 3.10.180.10)
|
8.131.708000.451 | Isomerization | Adjacent bond; O=C-C to O-C=C | Base/Stabilizer; Inorganic-cofactor-bound to double-bonded atom; Base deprotonation of initially single-bonded atom leading to isomerization; Stabilization of charge on finally single-bonded atom mechanism | An acidic residue + Asn (or Gln) + zinc ion bound to His cluster | S00235; Fructose-bisphosphate aldolase class 2
(Catalytic domain: 3.20.20.70)
|
8.131.712490.370 | Isomerization | Adjacent bond; O=C-C to O-C=C | Glucarate dehydratase 1st reaction step-like mechanism | His/Lys + magnesium ion bound to Asp/Glu/Asn | D00261; Glucarate dehydratase
(Catalytic domain: 3.20.20.120)
|
8.131.1241100.8201 | Isomerization | Adjacent bond; O=C-C to O-C=C | GDP fucose synthase 1st reaction step-like mechanism | Cys + Tyr/Lys bound to ribose-nicotinamide | D00604; GDP-L-fucose synthetase
(Catalytic domains: 3.40.50.720, 3.90.25.10)
|
8.211.591500.5520 | Isomerization | Adjacent bond; C=N-C to C-N=C | Base-Acid/Modulator; Organic-cofactor-bound to central atom; Modulator-assisted base deprotonation of initially single-bonded atom leading to intermediate; Modulator-assisted acid protonation to initially double-bonded atom mechanism | Lys/Tyr + PLP double-bonded to substrate/intermediate | D00265; Cystathionine gamma-synthase
(Catalytic domain: 3.40.640.10)
|
8.211.591500.5521 | Isomerization | Adjacent bond; C=N-C to C-N=C | Base-Acid/Modulator; Organic-cofactor-bound to central atom; Modulator-assisted base deprotonation of initially single-bonded atom leading to intermediate; Modulator-assisted acid protonation to initially double-bonded atom mechanism | Lys/Tyr + PLP covalently bound to substrate/intermediate | D00265; Cystathionine gamma-synthase
(Catalytic domain: 3.40.640.10)
|
8.211.591510.5526 | Isomerization | Adjacent bond; C=N-C to C-N=C | Base-Acid/Modulator; Organic-cofactor-bound to central atom; Modulator-assisted stabilization of organic cofactor; Base deprotonation of initially single-bonded atom leading to intermediate; Acid protonation to initially double-bonded atom mechanism | Lys + an acidic residue + Tyr + PLP double-bonded to substrate/intermediate | D00101; Aspartate aminotransferase
(Catalytic domain: 3.40.640.10)
D00102; Tyrosine aminotransferase
(Catalytic domain: 3.40.640.10)
D00105; D-alanine aminotransferase
(Catalytic domains: 3.20.10.10, 3.30.470.10)
D00108; Aromatic-amino-acid aminotransferase
(Catalytic domain: 3.40.640.10)
|
8.211.591510.5527 | Isomerization | Adjacent bond; C=N-C to C-N=C | Base-Acid/Modulator; Organic-cofactor-bound to central atom; Modulator-assisted stabilization of organic cofactor; Base deprotonation of initially single-bonded atom leading to intermediate; Acid protonation to initially double-bonded atom mechanism | Lys + an acidic residue + Tyr + PLP covalently bound to substrate/intermediate | D00101; Aspartate aminotransferase
(Catalytic domain: 3.40.640.10)
D00102; Tyrosine aminotransferase
(Catalytic domain: 3.40.640.10)
D00105; D-alanine aminotransferase
(Catalytic domains: 3.20.10.10, 3.30.470.10)
D00108; Aromatic-amino-acid aminotransferase
(Catalytic domain: 3.40.640.10)
|
8.11113.45000.86 | Isomerization | Non-adjacent bond; C=C-C=C-O to C-C=C-C=O | Base-Acid/Modulator; Modulator-assisted base-acid; Base deprotonation of initially single-bonded atom leading to intermediate formation; Acid protonation to initially double-bonded atom mechanism | His/Asp | S00355; 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase
(Catalytic domain: 3.40.50.1820)
S00526; 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase
(Catalytic domain: 3.40.50.1820)
|
8.11113.362040.140 | Isomerization | Non-adjacent bond; C=C-C=C-O to C-C=C-C=O | Dodecenoyl-CoA delta-isomerase 2nd reaction step-like mechanism | An acidic residue + mainchain amide groups | S00849; 3,2-trans-enoyl-CoA isomerase (EC 5.3.3.8) (Dodecenoyl-CoA isomerase) (Delta
(Catalytic domain: 3.90.226.10)
|
8.11121.166400.120 | Isomerization | Non-adjacent bond; N=C-C=C-C to N-C=C-C=C | Base; Electrophilic dobule-bonded atom; Electrophile-assisted reaction; Base deprotonation of initially-single-bonded atom completes reaction mechanism | Lys | S00239; Delta-aminolevulinic acid dehydratase
(Catalytic domain: 3.20.20.70)
S00537; Delta-aminolevulinic acid dehydratase
(Catalytic domain: 3.20.20.70)
S00538; Delta-aminolevulinic acid dehydratase
(Catalytic domain: 3.20.20.70)
S00539; Delta-aminolevulinic acid dehydratase
(Catalytic domain: 3.20.20.70)
|
8.11131.365050.86 | Isomerization | Non-adjacent bond; O=C-C=C-C to O-C=C-C=C | Acid/Modulator; Bond cleavage adjacent to single-bonded atom triggers reaction; Modulator-assisted acid protonation to initially-double-bonded atom mechanism | His/Asp | S00355; 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase
(Catalytic domain: 3.40.50.1820)
S00526; 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase
(Catalytic domain: 3.40.50.1820)
|
8.11211.912000.5510 | Isomerization | Non-adjacent bond; C=N-C=C-C to C-N=C-C=C | Acid/Modulator; Organic-cofactor-bound to central atom; Modulator-assisted acid protonation to initially double-bonded atom mechanism | Lys/His + PLP double-bonded to substrate/intermediate | T00089; Tryptophan synthase alpha chain
(Catalytic domains: 3.20.20.70, 3.40.50.1100)
|
8.11211.912000.5525 | Isomerization | Non-adjacent bond; C=N-C=C-C to C-N=C-C=C | Acid/Modulator; Organic-cofactor-bound to central atom; Modulator-assisted acid protonation to initially double-bonded atom mechanism | Lys+ Arg/Asp + PLP covalently bound to substrate/intermediate | D00271; Alanine racemase
(Catalytic domains: 2.40.37.10, 3.20.20.10)
|
8.11211.913550.5730 | Isomerization | Non-adjacent bond; C=N-C=C-C to C-N=C-C=C | Acid; Organic-cofactor-bound to central atom; Acid protonation to initially double-bonded atom mechanism | Tyr + PLP covalently bound to substrate/intermediate | D00085; Serine hydroxymethyltransferase
(Catalytic domain: 3.40.640.10)
|
8.12111.711000.5510 | Isomerization | Non-adjacent bond; C=C-C=N-C to C-C=C-N=C | Base/Modulator; Organic-cofactor-bound to central atom; Modulator-assisted base deprotonation of initially single-bonded atom mechanism | Lys/His + PLP double-bonded to substrate/intermediate | T00089; Tryptophan synthase alpha chain
(Catalytic domains: 3.20.20.70, 3.40.50.1100)
|
8.12111.792000.5722 | Isomerization | Non-adjacent bond; C=C-C=N-C to C-C=C-N=C | Base/Modulator; Organic-cofactor-bound to central atom; Substrate-assisted deprotonation & protonation (proton transfer) to activate 2nd base; Modulator-assisted base deprotonation of initially single-bonded atom mechanism | Tyr +Arg/His + PLP double-bonded to substrate/intermediate | D00271; Alanine racemase
(Catalytic domains: 2.40.37.10, 3.20.20.10)
|
8.1121121.660330.5528 | Isomerization | Non-adjacent bond; N=C-C=C-C=N-C to N-C=C-C=C-N=C | Allinase 2nd reaction step-like mechanism | Tyr/Lys + an acidic residue + Tyr + PLP double-bonded to substrate/intermediate | T00407; Alliin lyase 1
(Catalytic domains: 2.10.25.30, 3.40.640.10)
|
9.1050.192630.8500 | Hydride transfer | From CH-OH to nicotinamide (NAD+/NADP+) | 6-phospho-alpha-glucosidase 1st reaction step-like mechanism | Manganese ion bound to Cys/His/O7-nicotinamide/substrate or intermediate | D00827; Maltose-6''-phosphate glucosidase
(Catalytic domain: 3.90.110.10)
|
9.1050.439970.118 | Hydride transfer | From CH-OH to nicotinamide (NAD+/NADP+) | Shikimate dehydrogenase-like oxidation mechanism | Lys/Asp | D00605; Quinate/shikimate dehydrogenase
(Catalytic domain: 3.40.192.10)
D00845; Shikimate dehydrogenase
(Catalytic domain: 3.40.192.10)
D00857; Shikimate 5-dehydrogenase-like protein HI0607
(Catalytic domains: 3.40.50.720, 3.40.192.10)
D00858; Quinate/shikimate dehydrogenase
(Catalytic domain: 3.40.192.10)
T00414; Fusion: chorismate mutase and shikimate 5-dehydrogenase
(Catalytic domain: 3.40.192.10)
|
9.1050.439980.119 | Hydride transfer | From CH-OH to nicotinamide (NAD+/NADP+) | GDP mannose dehydrogenase 1st & 3rd reaction step-like mechanism | Lys + Asp/Thr bound to water | T00227; UDP-glucose 6-dehydrogenase
(Catalytic domains: 1.10.1040.10, 3.40.50.720)
T00408; GDP-mannose 6-dehydrogenase
(Catalytic domains: 1.-.-.-, 3.40.50.720)
|
9.1050.440000.8010 | Hydride transfer | From CH-OH to nicotinamide (NAD+/NADP+) | Drosophia alcohol dehydrogenase-like oxidation mechanism | Tyr/Ser + Lys bound to ribose-nicotinamide | D00274; UDP-glucose 4-epimerase
(Catalytic domain: 3.40.50.720)
D00275; ADP-L-glycero-D-manno-heptose-6-epimerase
(Catalytic domains: 3.40.50.720, 3.90.25.10)
D00513; GDP-mannose 4,6 dehydratase 2
(Catalytic domains: 3.40.50.720, 3.90.25.10)
S00319; Alcohol dehydrogenase
(Catalytic domain: 3.40.50.720)
S00320; Acetoin(diacetyl) reductase
(Catalytic domain: 3.40.50.720)
S00324; Glucose 1-dehydrogenase
(Catalytic domain: 3.40.50.720)
S00325; 3-alpha-hydroxysteroid dehydrogenase
(Catalytic domain: 3.40.50.720)
S00326; 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase
(Catalytic domain: 3.40.50.720)
S00327; Estradiol 17-beta-dehydrogenase 1
(Catalytic domain: 3.40.50.720)
S00330; 7-alpha-hydroxysteroid dehydrogenase
(Catalytic domain: 3.40.50.720)
S00332; Tropinone reductase 2
(Catalytic domain: 3.40.50.720)
S00552; Tropinone reductase 1
(Catalytic domain: 3.40.50.720)
S00604; NADP-dependent mannitol dehydrogenase
(Catalytic domain: 3.40.50.720)
S00605; Sorbitol dehydrogenase
(Catalytic domain: 3.40.50.720)
S00608; 2-(R)-hydroxypropyl-CoM dehydrogenase
(Catalytic domain: 3.40.50.720)
S00610; 3-beta-hydroxysteroid dehydrogenase
(Catalytic domain: 3.40.50.720)
S00625; Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase
(Catalytic domain: 3.40.50.720)
|
9.1050.440000.8011 | Hydride transfer | From CH-OH to nicotinamide (NAD+/NADP+) | Drosophia alcohol dehydrogenase-like oxidation mechanism | Tyr/Thr + Lys bound to ribose-nicotinamide | D00262; dTDP-glucose 4,6-dehydratase 2
(Catalytic domain: 3.40.50.720)
D00543; GDP-mannose 4,6-dehydratase
(Catalytic domains: 3.40.50.720, 3.90.25.10)
D00544; UDP-glucose 4-epimerase
(Catalytic domain: 3.40.50.720)
|
9.1050.584160.119 | Hydride transfer | From CH-OH to nicotinamide (NAD+/NADP+) | GDP mannose dehydrogenase 3rd reaction step-like mechanism | Lys + Asp/Thr bound to water | T00227; UDP-glucose 6-dehydrogenase
(Catalytic domains: 1.10.1040.10, 3.40.50.720)
T00408; GDP-mannose 6-dehydrogenase
(Catalytic domains: 1.-.-.-, 3.40.50.720)
|
9.1050.584160.160 | Hydride transfer | From CH-OH to nicotinamide (NAD+/NADP+) | GDP mannose dehydrogenase 3rd reaction step-like mechanism | [Asn or Gln] + mainchain amide group + Cys covalently-bound to substrate/intermediate | D00021; Betaine aldehyde dehydrogenase
(Catalytic domains: 3.40.309.10, 3.40.605.10)
|
9.5010.194230.8500 | Hydride transfer | From nicotinamide (NADH/NADPH) to C=O | 6-phospho-alpha-glucosidase 6th reaction step-like mechanism | Manganese ion bound to Cys/His/O7-nicotinamide/substrate or intermediate | D00827; Maltose-6''-phosphate glucosidase
(Catalytic domain: 3.90.110.10)
|
9.5010.536000.113 | Hydride transfer | From nicotinamide (NADH/NADPH) to C=O | HMG-CoA reductase class II 3rd reaction step-like mechanism | Lys + two acidic residues | D00607; 3-hydroxy-3-methylglutaryl-coenzyme A reductase
(Catalytic domain: 3.90.770.10)
|
9.5010.536000.976 | Hydride transfer | From nicotinamide (NADH/NADPH) to C=O | HMG-CoA reductase class II 3rd reaction step-like mechanism | Two acidic residues + Lys (interacting with each other) | M00180; 3-hydroxy-3-methylglutaryl-coenzyme A reductase
(Catalytic domains: 3.30.70.420, 3.90.770.10)
|
9.5010.536170.118 | Hydride transfer | From nicotinamide (NADH/NADPH) to C=O | Shikimate dehydrogenase-like reduction mechanism | Lys/Asp | D00605; Quinate/shikimate dehydrogenase
(Catalytic domain: 3.40.192.10)
D00845; Shikimate dehydrogenase
(Catalytic domain: 3.40.192.10)
D00857; Shikimate 5-dehydrogenase-like protein HI0607
(Catalytic domains: 3.40.50.720, 3.40.192.10)
D00858; Quinate/shikimate dehydrogenase
(Catalytic domain: 3.40.192.10)
T00414; Fusion: chorismate mutase and shikimate 5-dehydrogenase
(Catalytic domain: 3.40.192.10)
|
9.5010.536180.109 | Hydride transfer | From nicotinamide (NADH/NADPH) to C=O | Ketopantoate reductase-like reduction mechanism | Lys + an acidic residue + Asn or Gln + mainchain amide | D00603; 2-dehydropantoate 2-reductase
(Catalytic domains: 1.10.1040.10, 3.40.50.720)
|
9.5010.536200.8010 | Hydride transfer | From nicotinamide (NADH/NADPH) to C=O | dTDP dehydrorhamnose reductase-like mechanism | Tyr/Ser + Lys bound to ribose-nicotinamide | D00274; UDP-glucose 4-epimerase
(Catalytic domain: 3.40.50.720)
D00275; ADP-L-glycero-D-manno-heptose-6-epimerase
(Catalytic domains: 3.40.50.720, 3.90.25.10)
D00545; 3-oxoacyl-(Acyl-carrier protein) reductase
(Catalytic domain: 3.40.50.720)
D00604; GDP-L-fucose synthetase
(Catalytic domains: 3.40.50.720, 3.90.25.10)
S00319; Alcohol dehydrogenase
(Catalytic domain: 3.40.50.720)
S00320; Acetoin(diacetyl) reductase
(Catalytic domain: 3.40.50.720)
S00324; Glucose 1-dehydrogenase
(Catalytic domain: 3.40.50.720)
S00325; 3-alpha-hydroxysteroid dehydrogenase
(Catalytic domain: 3.40.50.720)
S00326; 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase
(Catalytic domain: 3.40.50.720)
S00327; Estradiol 17-beta-dehydrogenase 1
(Catalytic domain: 3.40.50.720)
S00328; 3-oxoacyl-[acyl-carrier-protein] reductase
(Catalytic domain: 3.40.50.720)
S00329; Sepiapterin reductase
(Catalytic domain: 3.40.50.720)
S00331; Sniffer
(Catalytic domain: 3.40.50.720)
S00332; Tropinone reductase 2
(Catalytic domain: 3.40.50.720)
S00336; Tetrahydroxynaphthalene reductase
(Catalytic domain: 3.40.50.720)
S00543; Carbonyl reductase [NADPH] 1
(Catalytic domain: 3.40.50.720)
S00552; Tropinone reductase 1
(Catalytic domain: 3.40.50.720)
S00553; 3-oxoacyl-[acyl carrier protein] reductase
(Catalytic domain: 3.40.50.720)
S00602; L-xylulose reductase
(Catalytic domain: 3.40.50.720)
S00604; NADP-dependent mannitol dehydrogenase
(Catalytic domain: 3.40.50.720)
S00605; Sorbitol dehydrogenase
(Catalytic domain: 3.40.50.720)
S00608; 2-(R)-hydroxypropyl-CoM dehydrogenase
(Catalytic domain: 3.40.50.720)
S00610; 3-beta-hydroxysteroid dehydrogenase
(Catalytic domain: 3.40.50.720)
|
9.5010.536200.8011 | Hydride transfer | From nicotinamide (NADH/NADPH) to C=O | dTDP dehydrorhamnose reductase-like mechanism | Tyr/Thr + Lys bound to ribose-nicotinamide | D00544; UDP-glucose 4-epimerase
(Catalytic domain: 3.40.50.720)
D00601; dTDP-4-dehydrorhamnose reductase
(Catalytic domain: 3.40.50.720)
|
9.5010.536210.8010 | Hydride transfer | From nicotinamide (NADH/NADPH) to C=O | GDP mannose dehydratase-final reaction step-like mechanism | Tyr/Ser + Lys bound to ribose-nicotinamide | D00513; GDP-mannose 4,6 dehydratase 2
(Catalytic domains: 3.40.50.720, 3.90.25.10)
|
9.5010.536210.8011 | Hydride transfer | From nicotinamide (NADH/NADPH) to C=O | GDP mannose dehydratase-final reaction step-like mechanism | Tyr/Thr + Lys bound to ribose-nicotinamide | D00262; dTDP-glucose 4,6-dehydratase 2
(Catalytic domain: 3.40.50.720)
D00543; GDP-mannose 4,6-dehydratase
(Catalytic domains: 3.40.50.720, 3.90.25.10)
|
9.5010.584100.113 | Hydride transfer | From nicotinamide (NADH/NADPH) to C=O | HMG-CoA reductase class II 1st reaction step-like mechanism | Lys + two acidic residues | D00607; 3-hydroxy-3-methylglutaryl-coenzyme A reductase
(Catalytic domain: 3.90.770.10)
|
9.5010.584100.976 | Hydride transfer | From nicotinamide (NADH/NADPH) to C=O | HMG-CoA reductase class II 1st reaction step-like mechanism | Two acidic residues + Lys (interacting with each other) | M00180; 3-hydroxy-3-methylglutaryl-coenzyme A reductase
(Catalytic domains: 3.30.70.420, 3.90.770.10)
|
10.12100.110.10080 | Electron transfer | From dicopper (Cu-Cu) to Heme-Fe | Indirect transfer through protein residues + cofactor atoms; No covalent bond formation/cleavage mechanism | His bound to Cu-Cu + mainchain groups + Heme-acidic groups | M00062; Cytochrome c oxidase subunit 1-beta
(Catalytic domains: 1.20.210.10, 2.60.40.420)
M00194; Cytochrome c oxidase subunit 1
(Catalytic domains: 1.20.210.10, 2.60.40.420)
|
10.21001.100.10900 | Electron transfer | From [2Fe-2S] cluster to Fe | Indirect transfer through protein residues; No covalent bond formation/cleavage mechanism | An acidic residue between His bound to [2Fe-2S] (bound to 2 x Cys/His cluster) + His bound to Fe3+ (bound to His/His/Asp cluster) | T00024; Naphthalene 1,2-dioxygenase subunit alpha
(Catalytic domains: 2.102.10.10, 3.90.380.10)
|
10.21011.100.10210 | Electron transfer | From [2Fe-2S] cluster to diiron (Fe-Fe) | Indirect transfer through protein residues; No covalent bond formation/cleavage mechanism | Trp/Acidic residue + His bound to Fe-Fe (bound to Glu/His cluster) | S00028; Acyl-[acyl-carrier-protein] desaturase
(Catalytic domain: 1.10.620.20)
|
10.21021.100.10205 | Electron transfer | From [2Fe-2S] cluster to [2Fe-2S] cluster | Indirect transfer through protein residues; No covalent bond formation/cleavage mechanism | Trp + hydrophobic residue + Cys bound to [2Fe-2S] (bound to 2 x Cys/His cluster) | T00024; Naphthalene 1,2-dioxygenase subunit alpha
(Catalytic domains: 2.102.10.10, 3.90.380.10)
|
10.21022.100.10500 | Electron transfer | From [2Fe-2S] cluster to [4Fe-4S] cluster | Indirect transfer through protein residues; No covalent bond formation/cleavage mechanism | Cys bound to [4Fe-4S] (bound to three Cys/His cluster) | M00042; Iron hydrogenase 1
(Catalytic domains: 1.10.287.430, 3.10.20.30, 3.30.70.20, 3.40.50.1780, 3.40.950.10)
|
10.21022.100.10510 | Electron transfer | From [2Fe-2S] cluster to [4Fe-4S] cluster | Indirect transfer through protein residues; No covalent bond formation/cleavage mechanism | Cys bound to [2Fe-2S] (bound to four Cys cluster) + Cys bound to [4Fe-4S] (bound to four Cys cluster) | M00042; Iron hydrogenase 1
(Catalytic domains: 1.10.287.430, 3.10.20.30, 3.30.70.20, 3.40.50.1780, 3.40.950.10)
|
10.21100.110.10515 | Electron transfer | From [2Fe-2S] cluster to Heme-Fe | Indirect transfer through protein residues + cofactor atoms; No covalent bond formation/cleavage mechanism | Cys bound to [2Fe-2S] (bound to four Cys cluster) + Acidic residue + Arg + Heme-acidic group | S00033; Camphor 5-monooxygenase
(Catalytic domain: 1.10.630.10)
|
10.22022.100.10700 | Electron transfer | From [4Fe-4S] cluster to [4Fe-4S] cluster | Indirect transfer through protein residues; No covalent bond formation/cleavage mechanism | Hydrophobic residue between Cys/His bound to [4Fe-4S] (bound to three Cys/His cluster) + Cys/Cys bound to [4Fe-4S] (bound to four Cys cluster) | M00042; Iron hydrogenase 1
(Catalytic domains: 1.10.287.430, 3.10.20.30, 3.30.70.20, 3.40.50.1780, 3.40.950.10)
|
10.22022.100.10750 | Electron transfer | From [4Fe-4S] cluster to [4Fe-4S] cluster | Indirect transfer through protein residues; No covalent bond formation/cleavage mechanism | Met between Cys residues bound to two [4Fe-4S] clusters (bound to four Cys clusters) | M00042; Iron hydrogenase 1
(Catalytic domains: 1.10.287.430, 3.10.20.30, 3.30.70.20, 3.40.50.1780, 3.40.950.10)
|
10.22022.100.10751 | Electron transfer | From [4Fe-4S] cluster to [4Fe-4S] cluster | Indirect transfer through protein residues; No covalent bond formation/cleavage mechanism | Hydrophobic residue between Cys residues bound to two [4Fe-4S] clusters (bound to four Cys clusters) | M00012; Periplasmic [Fe] hydrogenase large subunit
(Catalytic domains: 3.40.50.1780, 3.40.950.10)
|
10.22023.100.10525 | Electron transfer | From [4Fe-4S] cluster to [3Fe-4S] cluster | Indirect transfer through protein residues; No covalent bond formation/cleavage mechanism | Cys bound to [4Fe-4S] (bound to three Cys/His cluster) + Cys bound to [3Fe-4S] (bound to three Cys cluster) | T00030; Periplasmic [NiFe] hydrogenase large subunit
(Catalytic domains: 1.10.645.10, 3.40.50.700, 4.10.480.10)
|
10.22025.100.10760 | Electron transfer | From [4Fe-4S] cluster to [8Fe-7S] cluster (P cluster) | Indirect transfer through protein residues; No covalent bond formation/cleavage mechanism | Hydrophobic residue between Cys bound to [4Fe-4S] (bound to four Cys cluster) + Cys bound to [8Fe-7S] (P cluster) (bound to six Cys/Ser cluster) | M00114; Nitrogenase molybdenum-iron protein alpha chain
(Catalytic domains: 3.40.50.300, 3.40.50.1980)
|
10.22025.100.10765 | Electron transfer | From [4Fe-4S] cluster to [8Fe-7S] cluster (P cluster) | Indirect transfer through protein residues; No covalent bond formation/cleavage mechanism | Thr (or Ser) between Cys bound to [4Fe-4S] (bound to four Cys cluster) + Cys bound to [8Fe-7S] (P cluster) (bound to six Cys/Ser cluster) | M00199; Nitrogenase molybdenum-iron protein alpha chain
(Catalytic domains: 3.40.50.300, 3.40.50.1980)
|
10.22100.110.10570 | Electron transfer | From [4Fe-4S] cluster to Heme-Fe | Indirect transfer through protein residues + cofactor atoms; No covalent bond formation/cleavage mechanism | Cys bound to [4Fe-4S] (bound to four Cys cluster) + Cys covalently bonded to Heme group + Heme-vinyl group | M00012; Periplasmic [Fe] hydrogenase large subunit
(Catalytic domains: 3.40.50.1780, 3.40.950.10)
|
10.22120.100.10610 | Electron transfer | From [4Fe-4S] cluster to H cluster ([4Fe-4S]/diiron/bridging cys) | Indirect transfer through protein residues; No covalent bond formation/cleavage mechanism | Gln between Cys bound to [4Fe-4S] (bound to four Cys cluster) + Cys bound to H cluster (bound to four Cys cluster) | M00042; Iron hydrogenase 1
(Catalytic domains: 1.10.287.430, 3.10.20.30, 3.30.70.20, 3.40.50.1780, 3.40.950.10)
|
10.22140.100.10551 | Electron transfer | From [4Fe-4S] cluster to Ni-Fe(CN)2(CO) | Indirect transfer through protein residues; No covalent bond formation/cleavage mechanism | Cys bound to [4Fe-4S] (bound to four Cys cluster) + Cys bound to Ni-Fe(CN)2(CO) (bound to four Cys cluster) | T00030; Periplasmic [NiFe] hydrogenase large subunit
(Catalytic domains: 1.10.645.10, 3.40.50.700, 4.10.480.10)
|
10.23022.100.10580 | Electron transfer | From [3Fe-4S] cluster to [4Fe-4S] cluster | Indirect transfer through protein residues; No covalent bond formation/cleavage mechanism | Cys bound to [3Fe-4S] (bound to three Cys cluster) + Cys bound to [4Fe-4S] (bound to four Cys cluster) | T00030; Periplasmic [NiFe] hydrogenase large subunit
(Catalytic domains: 1.10.645.10, 3.40.50.700, 4.10.480.10)
|
10.25130.110.10590 | Electron transfer | From [8Fe-7S] cluster (P cluster) to [Mo-7Fe-9S] cluster + homocitrate (FeMoco) | Indirect transfer through protein residues + cofactor atoms; No covalent bond formation/cleavage mechanism | Cys bound to [8Fe-7S] (P cluster) (bound to six Cys/Ser cluster) + Gln bound to homocitrate (bound to Gln/His/Ile + FeMoco (bound to His/Cys)) | M00114; Nitrogenase molybdenum-iron protein alpha chain
(Catalytic domains: 3.40.50.300, 3.40.50.1980)
M00199; Nitrogenase molybdenum-iron protein alpha chain
(Catalytic domains: 3.40.50.300, 3.40.50.1980)
|
10.100012.100.10200 | Electron transfer | From Heme-Fe to dicopper (Cu-Cu) | Indirect transfer through protein residues; No covalent bond formation/cleavage mechanism | Trp + Met bound to Cu-Cu (bound to Cys/His/Met/Glu cluster) | M00062; Cytochrome c oxidase subunit 1-beta
(Catalytic domains: 1.20.210.10, 2.60.40.420)
|
10.100012.100.10290 | Electron transfer | From Heme-Fe to dicopper (Cu-Cu) | Indirect transfer through protein residues; No covalent bond formation/cleavage mechanism | Mainchain atoms + Met bound to Cu-Cu (bound to Cys/His/Met/Gln cluster) | M00194; Cytochrome c oxidase subunit 1
(Catalytic domains: 1.20.210.10, 2.60.40.420)
|
10.100110.100.10300 | Electron transfer | From Heme-Fe to Heme-Fe/Cu | Indirect transfer through protein residues; No covalent bond formation/cleavage mechanism | Mainchain atoms between two His residues (axial ligands) bound to (Heme-Fe)2 | M00062; Cytochrome c oxidase subunit 1-beta
(Catalytic domains: 1.20.210.10, 2.60.40.420)
M00194; Cytochrome c oxidase subunit 1
(Catalytic domains: 1.20.210.10, 2.60.40.420)
|
10.120022.100.10610 | Electron transfer | From H cluster ([4Fe-4S]/diiron/bridging cys) to [4Fe-4S] cluster | Indirect transfer through protein residues; No covalent bond formation/cleavage mechanism | Gln between Cys bound to [4Fe-4S] (bound to four Cys cluster) + Cys bound to H cluster (bound to four Cys cluster) | M00012; Periplasmic [Fe] hydrogenase large subunit
(Catalytic domains: 3.40.50.1780, 3.40.950.10)
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10.400410.30292300.20000 | Electron transfer | From sulfhydryl to disulfide | Direct transfer through thiol-disulfide exchange (Nucleophile); Nucleophile attacks on target disulfide bond; New bond formation and cleavage accompanied by electron transfer mechanism | Cys + Cys-Cys(disulfide bond) | |
