RLCP 6.30.115000.5080 :EzCatDB EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms


R 6.-.-.- : Exchange of double-bonded atoms (Schiff-base related reaction) (Reaction)

L 6.30.-.- : Exchange of Schiff-base nitrogen atoms (external aldimine formation) (Ligand group involved)

C 6.30.115000.- : Base/Modulator; Cofactor-assisted activation of substituted group; Activated substituted group attacks on double-bond partner atom; Formation of tetrahedral intermediate; Base-activation of nucleophile; Lone pair on nucleophile attacks again on double-bond partner atom (Catalytic mechanism)

P 6.30.115000.5080 : His + His/Ser + an acidic residue + PLP double-bonded to Lys (Residues/cofactors in Protein)

1st Nucleophile : Substituted group (substrate or water)
Catalytic groups : cofactor + groups in residue/substrate
General Base : a group in substrate/cofactor
General Acid : a group in substrate/cofactor

Related Enzymes

There are 2 entries in this class.
  • D00092 : (reaction 1) 2.3.1.47; 8-amino-7-oxononanoate synthase (Catalytic domains; 3.40.640.10, 3.90.1150.10)
  • D00639 : (reaction 1) 2.3.1.29; 2-amino-3-ketobutyrate coenzyme A ligase (Catalytic domain; 3.40.640.10)
    • Copyright: Nozomi Nagano, JST & CBRC-AIST
    Funded by PRESTO/Japan Science and Technology Agency (JST) (December 2001 - November 2004)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
    Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (September 2005 - September 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (October 2007 - September 2010)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2012 - March 2013)
    Supported by the commission for the Development of Artificial Gene Synthesis Technology for Creating Innovative Biomaterial from the Ministry of Economy, Trade and Industry (METI) (October 2012 - March 2016)
    Funded by the project commissioned by the New Energy and Industrial Technology Development Organization (NEDO) (April 2016 -)