DB code: M00197
| RLCP classification | 3.103.126600.1165 : Transfer | |
|---|---|---|
| CATH domain | 3.30.200.20 : Phosphorylase Kinase; domain 1 | Catalytic domain |
| 1.10.510.10 : Transferase(Phosphotransferase); domain 1 | Catalytic domain | |
| 1.10.1820.10 : protein kinase ck2 holoenzyme, chain C, domain 1 | ||
| 2.20.25.20 : N-terminal domain of TfIIb | ||
| E.C. | 2.7.11.1 | |
| CSA | ||
| M-CSA | ||
| MACiE | ||
| CATH domain | Related DB codes (homologues) |
|---|---|
| 1.10.510.10 : Transferase(Phosphotransferase); domain 1 | M00125 M00124 M00131 T00224 M00127 M00129 M00130 M00132 M00136 M00196 M00198 M00304 M00323 M00325 M00326 M00327 M00328 M00329 M00330 M00331 M00332 M00333 M00335 M00339 M00344 |
| 3.30.200.20 : Phosphorylase Kinase; domain 1 | M00125 M00124 M00131 T00224 M00127 M00129 M00130 M00132 M00136 M00196 M00198 M00304 M00323 M00325 M00326 M00327 M00328 M00329 M00330 M00331 M00332 M00333 M00335 M00339 M00344 D00298 |
| Uniprot Enzyme Name | UniprotKB | Protein name | Synonyms | Pfam | RefSeq |
|---|---|---|---|---|
| P28020 |
Casein kinase II subunit alpha
|
CK II
EC 2.7.11.1 |
PF00069
(Pkinase)
[Graphical View] |
|
| P68400 |
Casein kinase II subunit alpha
|
CK II alpha
EC 2.7.11.1 |
PF00069
(Pkinase)
[Graphical View] |
NP_001886.1
(Protein)
NM_001895.3 (DNA/RNA sequence) NP_808227.1 (Protein) NM_177559.2 (DNA/RNA sequence) NP_808228.1 (Protein) NM_177560.2 (DNA/RNA sequence) |
| Q6INV5 |
|
Ck2a1 protein
|
PF00069
(Pkinase)
[Graphical View] |
NP_001084124.1
(Protein)
NM_001090655.1 (DNA/RNA sequence) |
| P19784 |
Casein kinase II subunit alpha''
|
CK II alpha''
EC 2.7.11.1 |
PF00069
(Pkinase)
[Graphical View] |
NP_001887.1
(Protein)
NM_001896.2 (DNA/RNA sequence) |
| P28021 |
Casein kinase II subunit beta
|
CK II beta
Phosvitin |
PF01214
(CK_II_beta)
[Graphical View] |
NP_001084126.1
(Protein)
NM_001090657.1 (DNA/RNA sequence) |
| P67870 |
Casein kinase II subunit beta
|
CK II beta
Phosvitin Protein G5a |
PF01214
(CK_II_beta)
[Graphical View] |
NP_001311.3
(Protein)
NM_001320.5 (DNA/RNA sequence) |
| KEGG enzyme name |
|---|
|
Non-specific serine/threonine protein kinase
A-kinase AP50 kinase ATP-protein transphosphorylase Calcium-dependent protein kinase C Calcium/phospholipid-dependent protein kinase cAMP-dependent protein kinase cAMP-dependent protein kinase A Casein kinase Casein kinase (phosphorylating) Casein kinase 2 Casein kinase I Casein kinase II cGMP-dependent protein kinase CK-2 CKI CKII Cyclic AMP-dependent protein kinase Cyclic AMP-dependent protein kinase A Cyclic monophosphate-dependent protein kinase Cyclic nucleotide-dependent protein kinase Cyclin-dependent kinase Cytidine 3',5'-cyclic monophosphate-responsive protein kinase dsk1 Glycogen synthase a kinase Glycogen synthase kinase HIPK2 Hpr kinase Hydroxyalkyl-protein kinase Hydroxyalkyl-protein kinase M phase-specific cdc2 kinase Mitogen-activated S6 kinase p82 kinase Phosphorylase b kinase kinase PKA Protein glutamyl kinase Protein kinase (phosphorylating) Protein kinase A Protein kinase CK2 Protein kinase p58 Protein phosphokinase Protein serine kinase Protein serine-threonine kinase Protein-aspartyl kinase Protein-cysteine kinase Protein-serine kinase Prp4 protein kinase Raf kinase Raf-1 Ribosomal protein S6 kinase II Ribosomal S6 protein kinase Serine kinase Serine protein kinase Serine-specific protein kinase Serine(threonine) protein kinase Serine/threonine protein kinase STK32 T-antigen kinase Threonine-specific protein kinase Twitchin kinase Type-2 casein kinase betaIIPKC epsilon PKC Wee 1-like kinase Wee-kinase WEE1Hu |
| UniprotKB: Accession Number | Entry name | Activity | Subunit | Subcellular location | Cofactor |
|---|---|---|---|---|---|
| P28020 | CSK21_XENLA | ATP + a protein = ADP + a phosphoprotein. | Tetramer composed of an alpha chain, an alpha' and two beta chains. | ||
| P68400 | CSK21_HUMAN | ATP + a protein = ADP + a phosphoprotein. | Tetramer composed of an alpha chain, an alpha' and two beta chains. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. Interacts with RNPS1. | ||
| Q6INV5 | Q6INV5_XENLA | ||||
| P19784 | CSK22_HUMAN | ATP + a protein = ADP + a phosphoprotein. | Tetramer composed of an alpha chain, an alpha' and two beta chains. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. | ||
| P28021 | CSK2B_XENLA | Tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits (By similarity). | |||
| P67870 | CSK2B_HUMAN | Tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. |
| KEGG Pathways | Map code | Pathways | E.C. |
|---|
| Compound table | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cofactors | Substrates | Products | Intermediates | |||||||||
| KEGG-id | C00305 | C00038 | C00002 | C00017 | C00008 | C00562 | ||||||
| E.C. | ||||||||||||
| Compound | Magnesium | Zinc | ATP | Protein | ADP | Phosphoprotein | ||||||
| Type | divalent metal (Ca2+, Mg2+) | heavy metal | amine group,nucleotide | peptide/protein | amine group,nucleotide | peptide/protein,phosphate group/phosphate ion | ||||||
| ChEBI |
18420 18420 |
29105 29105 |
15422 15422 |
16761 16761 |
||||||||
| PubChem |
888 888 |
32051 32051 |
5957 5957 |
6022 6022 |
||||||||
| 1jwhA01 |
|
|
|
|
|
Unbound | Unbound | Analogue:ANP | Unbound | Unbound | Unbound | |
| 1jwhB01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1na7A01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1pjkA01 |
|
|
|
|
|
Unbound | Unbound | Analogue:ANP | Unbound | Unbound | Unbound | |
| 1ymiA02 |
|
|
|
|
|
Unbound | Unbound | Analogue:ANP | Unbound | Unbound | Unbound | |
| 2pvrA02 |
|
|
|
|
|
Unbound | Unbound | Analogue:ANP | Unbound | Unbound | Unbound | |
| 2zjwA02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3bqcA02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3c13A02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3fwqA02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3fwqB02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3h30A02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3h30B02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3juhA02 |
|
|
|
|
|
Unbound | Unbound | Analogue:ANP | Unbound | Unbound | Unbound | |
| 3juhB02 |
|
|
|
|
|
Unbound | Unbound | Analogue:ANP | Unbound | Unbound | Unbound | |
| 3mb6A02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3mb7A02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3ngaA02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3ngaB02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3nszA02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Analogue:ANP | Unbound | |
| 3e3bX02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3ofmA02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1jwhA02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1jwhB02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1na7A02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1pjkA02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ymiA01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2pvrA01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2zjwA01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3bqcA01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3c13A01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3fwqA01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3fwqB01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3h30A01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3h30B01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3juhA01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3juhB01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3mb6A01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3mb7A01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3ngaA01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3ngaB01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3nszA01 |
|
|
|
|
|
Bound:2x_MG | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3e3bX01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3ofmA01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1rqfA01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1rqfB01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1rqfD01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1rqfE01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1rqfG01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1rqfH01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1rqfJ01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1rqfK01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1jwhC01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1jwhD01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qf8A01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qf8B01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3eedA01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3eedB01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1rqfA02 |
|
|
|
|
|
Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | |
| 1rqfB02 |
|
|
|
|
|
Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | |
| 1rqfD02 |
|
|
|
|
|
Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | |
| 1rqfE02 |
|
|
|
|
|
Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | |
| 1rqfG02 |
|
|
|
|
|
Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | |
| 1rqfH02 |
|
|
|
|
|
Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | |
| 1rqfJ02 |
|
|
|
|
|
Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | |
| 1rqfK02 |
|
|
|
|
|
Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | |
| 1jwhC02 |
|
|
|
|
|
Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | |
| 1jwhD02 |
|
|
|
|
|
Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | |
| 1qf8A02 |
|
|
|
|
|
Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | |
| 1qf8B02 |
|
|
|
|
|
Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | |
| 3eedA02 |
|
|
|
|
|
Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | |
| 3eedB02 |
|
|
|
|
|
Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | |
| Reference for Active-site residues | ||
|---|---|---|
| resource | references | E.C. |
| literature [2], [8] | ||
| Active-site residues | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Catalytic residues | Cofactor-binding residues | Modified residues | Main-chain involved in catalysis | Comment | |||||
| 1jwhA01 |
|
|
|
|
|
LYS 68 | LYS 49;TYR 50;SER 51 | |||
| 1jwhB01 |
|
|
|
|
|
LYS 68 | LYS 49;TYR 50;SER 51 | |||
| 1na7A01 |
|
|
|
|
|
LYS 68 | LYS 49;TYR 50;SER 51 | mutant E27A, K76N | ||
| 1pjkA01 |
|
|
|
|
|
LYS 68 | LYS 49;TYR 50;SER 51 | |||
| 1ymiA02 |
|
|
|
|
|
LYS 68 | LYS 49;TYR 50;SER 51 | mutant V66A | ||
| 2pvrA02 |
|
|
|
|
|
LYS 68 | LYS 49;TYR 50;SER 51 | |||
| 2zjwA02 |
|
|
|
|
|
LYS 68 | LYS 49;TYR 50;SER 51 | |||
| 3bqcA02 |
|
|
|
|
|
LYS 68 | LYS 49;TYR 50;SER 51 | |||
| 3c13A02 |
|
|
|
|
|
LYS 68 | LYS 49;TYR 50;SER 51 | |||
| 3fwqA02 |
|
|
|
|
|
LYS 68 | LYS 49;TYR 50;SER 51 | |||
| 3fwqB02 |
|
|
|
|
|
LYS 68 | LYS 49;TYR 50;SER 51 | |||
| 3h30A02 |
|
|
|
|
|
LYS 68 | LYS 49;TYR 50;SER 51 | |||
| 3h30B02 |
|
|
|
|
|
LYS 68 | LYS 49;TYR 50;SER 51 | |||
| 3juhA02 |
|
|
|
|
|
LYS 68 | LYS 49;TYR 50;SER 51 | |||
| 3juhB02 |
|
|
|
|
|
LYS 68 | LYS 49;TYR 50;SER 51 | |||
| 3mb6A02 |
|
|
|
|
|
LYS 68 | LYS 49;TYR 50;SER 51 | |||
| 3mb7A02 |
|
|
|
|
|
LYS 68 | LYS 49;TYR 50;SER 51 | |||
| 3ngaA02 |
|
|
|
|
|
LYS 68 | LYS 49;TYR 50;SER 51 | |||
| 3ngaB02 |
|
|
|
|
|
LYS 68 | LYS 49;TYR 50;SER 51 | |||
| 3nszA02 |
|
|
|
|
|
LYS 68 | LYS 49;TYR 50;SER 51 | |||
| 3e3bX02 |
|
|
|
|
|
LYS 69 | LYS 50;TYR 51;SER 52 | |||
| 3ofmA02 |
|
|
|
|
|
LYS 69 | LYS 50;TYR 51;SER 52 | |||
| 1jwhA02 |
|
|
|
|
|
ASP 156;LYS 158 | ASN 161(Magnesium-2 binding);ASP 175(Magnesium-1 binding) | |||
| 1jwhB02 |
|
|
|
|
|
ASP 156;LYS 158 | ASN 161(Magnesium-2 binding);ASP 175(Magnesium-1 binding) | |||
| 1na7A02 |
|
|
|
|
|
ASP 156;LYS 158 | ASN 161(Magnesium-2 binding);ASP 175(Magnesium-1 binding) | |||
| 1pjkA02 |
|
|
|
|
|
ASP 156;LYS 158 | ASN 161(Magnesium-2 binding);ASP 175(Magnesium-1 binding) | |||
| 1ymiA01 |
|
|
|
|
|
ASP 156;LYS 158 | ASN 161(Magnesium-2 binding);ASP 175(Magnesium-1 binding) | mutant M163L | ||
| 2pvrA01 |
|
|
|
|
|
ASP 156;LYS 158 | ASN 161(Magnesium-2 binding);ASP 175(Magnesium-1 binding) | |||
| 2zjwA01 |
|
|
|
|
|
ASP 156;LYS 158 | ASN 161(Magnesium-2 binding);ASP 175(Magnesium-1 binding) | |||
| 3bqcA01 |
|
|
|
|
|
ASP 156;LYS 158 | ASN 161(Magnesium-2 binding);ASP 175(Magnesium-1 binding) | |||
| 3c13A01 |
|
|
|
|
|
ASP 156;LYS 158 | ASN 161(Magnesium-2 binding);ASP 175(Magnesium-1 binding) | |||
| 3fwqA01 |
|
|
|
|
|
ASP 156;LYS 158 | ASN 161(Magnesium-2 binding);ASP 175(Magnesium-1 binding) | |||
| 3fwqB01 |
|
|
|
|
|
ASP 156;LYS 158 | ASN 161(Magnesium-2 binding);ASP 175(Magnesium-1 binding) | |||
| 3h30A01 |
|
|
|
|
|
ASP 156;LYS 158 | ASN 161(Magnesium-2 binding);ASP 175(Magnesium-1 binding) | |||
| 3h30B01 |
|
|
|
|
|
ASP 156;LYS 158 | ASN 161(Magnesium-2 binding);ASP 175(Magnesium-1 binding) | |||
| 3juhA01 |
|
|
|
|
|
ASP 156;LYS 158 | ASN 161(Magnesium-2 binding);ASP 175(Magnesium-1 binding) | |||
| 3juhB01 |
|
|
|
|
|
ASP 156;LYS 158 | ASN 161(Magnesium-2 binding);ASP 175(Magnesium-1 binding) | |||
| 3mb6A01 |
|
|
|
|
|
ASP 156;LYS 158 | ASN 161(Magnesium-2 binding);ASP 175(Magnesium-1 binding) | |||
| 3mb7A01 |
|
|
|
|
|
ASP 156;LYS 158 | ASN 161(Magnesium-2 binding);ASP 175(Magnesium-1 binding) | |||
| 3ngaA01 |
|
|
|
|
|
ASP 156;LYS 158 | ASN 161(Magnesium-2 binding);ASP 175(Magnesium-1 binding) | |||
| 3ngaB01 |
|
|
|
|
|
ASP 156;LYS 158 | ASN 161(Magnesium-2 binding);ASP 175(Magnesium-1 binding) | |||
| 3nszA01 |
|
|
|
|
|
ASP 156;LYS 158 | ASN 161(Magnesium-2 binding);ASP 175(Magnesium-1 binding) | |||
| 3e3bX01 |
|
|
|
|
|
ASP 157;LYS 159 | ASN 162(Magnesium-2 binding);ASP 176(Magnesium-1 binding) | |||
| 3ofmA01 |
|
|
|
|
|
ASP 157;LYS 159 | ASN 162(Magnesium-2 binding);ASP 176(Magnesium-1 binding) | |||
| 1rqfA01 |
|
|
|
|
|
|||||
| 1rqfB01 |
|
|
|
|
|
invisible 59-66 | ||||
| 1rqfD01 |
|
|
|
|
|
invisible 59-65 | ||||
| 1rqfE01 |
|
|
|
|
|
|||||
| 1rqfG01 |
|
|
|
|
|
invisible 59-67 | ||||
| 1rqfH01 |
|
|
|
|
|
invisible 59-67 | ||||
| 1rqfJ01 |
|
|
|
|
|
|||||
| 1rqfK01 |
|
|
|
|
|
invisible 59-66 | ||||
| 1jwhC01 |
|
|
|
|
|
|||||
| 1jwhD01 |
|
|
|
|
|
|||||
| 1qf8A01 |
|
|
|
|
|
invisible 60-65 | ||||
| 1qf8B01 |
|
|
|
|
|
invisible 59-66 | ||||
| 3eedA01 |
|
|
|
|
|
invisible 60-64 | ||||
| 3eedB01 |
|
|
|
|
|
invisible 60-64 | ||||
| 1rqfA02 |
|
|
|
|
|
CYS 109;CYS 114;CYS 137;CYS 140(Zinc binding) | ||||
| 1rqfB02 |
|
|
|
|
|
CYS 109;CYS 114;CYS 137;CYS 140(Zinc binding) | ||||
| 1rqfD02 |
|
|
|
|
|
CYS 109;CYS 114;CYS 137;CYS 140(Zinc binding) | ||||
| 1rqfE02 |
|
|
|
|
|
CYS 109;CYS 114;CYS 137;CYS 140(Zinc binding) | ||||
| 1rqfG02 |
|
|
|
|
|
CYS 109;CYS 114;CYS 137;CYS 140(Zinc binding) | ||||
| 1rqfH02 |
|
|
|
|
|
CYS 109;CYS 114;CYS 137;CYS 140(Zinc binding) | ||||
| 1rqfJ02 |
|
|
|
|
|
CYS 109;CYS 114;CYS 137;CYS 140(Zinc binding) | ||||
| 1rqfK02 |
|
|
|
|
|
CYS 109;CYS 114;CYS 137;CYS 140(Zinc binding) | ||||
| 1jwhC02 |
|
|
|
|
|
CYS 109;CYS 114;CYS 137;CYS 140(Zinc binding) | ||||
| 1jwhD02 |
|
|
|
|
|
CYS 109;CYS 114;CYS 137;CYS 140(Zinc binding) | ||||
| 1qf8A02 |
|
|
|
|
|
CYS 109;CYS 114;CYS 137;CYS 140(Zinc binding) | ||||
| 1qf8B02 |
|
|
|
|
|
CYS 109;CYS 114;CYS 137;CYS 140(Zinc binding) | ||||
| 3eedA02 |
|
|
|
|
|
CYS 109;CYS 114;CYS 137;CYS 140(Zinc binding) | ||||
| 3eedB02 |
|
|
|
|
|
CYS 109;CYS 114;CYS 137;CYS 140(Zinc binding) | ||||
| References for Catalytic Mechanism | ||
|---|---|---|
| References | Sections | No. of steps in catalysis |
| References | |
|---|---|
| [1] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7735313 |
| Journal | Cell Mol Biol Res |
| Year | 1994 |
| Volume | 40 |
| Pages | 391-9 |
| Authors | Boldyreff B, Meggio F, Pinna LA, Issinger OG |
| Title | Protein kinase CK2 structure-function relationship: effects of the beta subunit on reconstitution and activity. |
| Related PDB | |
| Related UniProtKB | |
| [2] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) |
| Medline ID | 98232491 |
| PubMed ID | 9564028 |
| Journal | EMBO J |
| Year | 1998 |
| Volume | 17 |
| Pages | 2451-62 |
| Authors | Niefind K, Guerra B, Pinna LA, Issinger OG, Schomburg D |
| Title | Crystal structure of the catalytic subunit of protein kinase CK2 from Zea mays at 2.1 A resolution. |
| Related PDB | 1a6o |
| Related UniProtKB | P28523 |
| [3] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 10357806 |
| Journal | EMBO J |
| Year | 1999 |
| Volume | 18 |
| Pages | 2930-40 |
| Authors | Chantalat L, Leroy D, Filhol O, Nueda A, Benitez MJ, Chambaz EM, Cochet C, Dideberg O |
| Title | Crystal structure of the human protein kinase CK2 regulatory subunit reveals its zinc finger-mediated dimerization. |
| Related PDB | 1qf8 |
| Related UniProtKB | |
| [4] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 10581548 |
| Journal | Nat Struct Biol |
| Year | 1999 |
| Volume | 6 |
| Pages | 1100-3 |
| Authors | Niefind K, Putter M, Guerra B, Issinger OG, Schomburg D |
| Title | GTP plus water mimic ATP in the active site of protein kinase CK2. |
| Related PDB | 1daw 1day |
| Related UniProtKB | |
| [5] | |
| Resource | |
| Comments |
X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF 1-337, |
| Medline ID | |
| PubMed ID | 11092945 |
| Journal | Acta Crystallogr D Biol Crystallogr |
| Year | 2000 |
| Volume | 56 |
| Pages | 1680-4 |
| Authors | Niefind K, Guerra B, Ermakowa I, Issinger OG |
| Title | Crystallization and preliminary characterization of crystals of human protein kinase CK2. |
| Related PDB | |
| Related UniProtKB | P68400 P67870 |
| [6] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 10931203 |
| Journal | Eur J Biochem |
| Year | 2000 |
| Volume | 267 |
| Pages | 5184-90 |
| Authors | Battistutta R, Sarno S, De Moliner E, Marin O, Issinger OG, Zanotti G, Pinna LA |
| Title | The crystal structure of the complex of Zea mays alpha subunit with a fragment of human beta subunit provides the clue to the architecture of protein kinase CK2 holoenzyme. |
| Related PDB | 1ds5 |
| Related UniProtKB | |
| [7] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 10882732 |
| Journal | J Biol Chem |
| Year | 2000 |
| Volume | 275 |
| Pages | 29618-22 |
| Authors | Battistutta R, Sarno S, De Moliner E, Papinutto E, Zanotti G, Pinna LA |
| Title | The replacement of ATP by the competitive inhibitor emodin induces conformational modifications in the catalytic site of protein kinase CK2. |
| Related PDB | 1f0q |
| Related UniProtKB | |
| [8] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 11574463 |
| Journal | EMBO J |
| Year | 2001 |
| Volume | 20 |
| Pages | 5320-31 |
| Authors | Niefind K, Guerra B, Ermakowa I, Issinger OG |
| Title | Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme. |
| Related PDB | 1jwh |
| Related UniProtKB | |
| [9] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 11604527 |
| Journal | Protein Sci |
| Year | 2001 |
| Volume | 10 |
| Pages | 2200-6 |
| Authors | Battistutta R, De Moliner E, Sarno S, Zanotti G, Pinna LA |
| Title | Structural features underlying selective inhibition of protein kinase CK2 by ATP site-directed tetrabromo-2-benzotriazole. |
| Related PDB | 1j91 1jam |
| Related UniProtKB | |
| [10] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12417343 |
| Journal | FEBS Lett |
| Year | 2002 |
| Volume | 531 |
| Pages | 363-8 |
| Authors | Tapia J, Jacob G, Allende CC, Allende JE |
| Title | Role of the carboxyl terminus on the catalytic activity of protein kinase CK2alpha subunit. |
| Related PDB | |
| Related UniProtKB | |
| [11] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11956194 |
| Journal | J Biol Chem |
| Year | 2002 |
| Volume | 277 |
| Pages | 22509-14 |
| Authors | Sarno S, Ghisellini P, Pinna LA |
| Title |
Unique activation mechanism of protein kinase CK2. |
| Related PDB | |
| Related UniProtKB | |
| [12] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 1-329. |
| Medline ID | |
| PubMed ID | 14646071 |
| Journal | Acta Crystallogr D Biol Crystallogr |
| Year | 2003 |
| Volume | 59 |
| Pages | 2133-9 |
| Authors | Pechkova E, Zanotti G, Nicolini C |
| Title | Three-dimensional atomic structure of a catalytic subunit mutant of human protein kinase CK2. |
| Related PDB | 1na7 |
| Related UniProtKB | P68400 |
| [13] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12396231 |
| Journal | Biochem J |
| Year | 2003 |
| Volume | 369 |
| Pages | 1-15 |
| Authors | Litchfield DW |
| Title |
Protein kinase CK2: structure, |
| Related PDB | |
| Related UniProtKB | |
| [14] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 12816539 |
| Journal | Biochem J |
| Year | 2003 |
| Volume | 374 |
| Pages | 639-46 |
| Authors | Sarno S, de Moliner E, Ruzzene M, Pagano MA, Battistutta R, Bain J, Fabbro D, Schoepfer J, Elliott M, Furet P, Meggio F, Zanotti G, Pinna LA |
| Title | Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA). |
| Related PDB | 1om1 |
| Related UniProtKB | |
| [15] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12740046 |
| Journal | BMC Struct Biol |
| Year | 2003 |
| Volume | 3 |
| Pages | 4 |
| Authors | Rekha N, Srinivasan N |
| Title | Structural basis of regulation and substrate specificity of protein kinase CK2 deduced from the modeling of protein-protein interactions. |
| Related PDB | |
| Related UniProtKB | |
| [16] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 12419810 |
| Journal | J Biol Chem |
| Year | 2003 |
| Volume | 278 |
| Pages | 1831-6 |
| Authors | De Moliner E, Moro S, Sarno S, Zagotto G, Zanotti G, Pinna LA, Battistutta R |
| Title |
Inhibition of protein kinase CK2 by anthraquinone-related compounds. |
| Related PDB | 1m2p 1m2q 1m2r |
| Related UniProtKB | |
| [17] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 2-335. |
| Medline ID | |
| PubMed ID | 12860116 |
| Journal | J Mol Biol |
| Year | 2003 |
| Volume | 330 |
| Pages | 925-34 |
| Authors | Ermakova I, Boldyreff B, Issinger OG, Niefind K |
| Title | Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit. |
| Related PDB | 1pjk |
| Related UniProtKB | P68400 |
| [18] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 15388915 |
| Journal | Acta Crystallogr D Biol Crystallogr |
| Year | 2004 |
| Volume | 60 |
| Pages | 1698-704 |
| Authors | Bertrand L, Sayed MF, Pei XY, Parisini E, Dhanaraj V, Bolanos-Garcia VM, Allende JE, Blundell TL |
| Title | Structure of the regulatory subunit of CK2 in the presence of a p21WAF1 peptide demonstrates flexibility of the acidic loop. |
| Related PDB | 1rqf |
| Related UniProtKB | |
| [19] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 16298300 |
| Journal | Chem Biol |
| Year | 2005 |
| Volume | 12 |
| Pages | 1211-9 |
| Authors | Battistutta R, Mazzorana M, Sarno S, Kazimierczuk Z, Zanotti G, Pinna LA |
| Title | Inspecting the structure-activity relationship of protein kinase CK2 inhibitors derived from tetrabromo-benzimidazole. |
| Related PDB | 1zoe 1zog 1zoh |
| Related UniProtKB | |
| [20] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 15740749 |
| Journal | J Mol Biol |
| Year | 2005 |
| Volume | 347 |
| Pages | 399-414 |
| Authors | Yde CW, Ermakova I, Issinger OG, Niefind K |
| Title | Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate. |
| Related PDB | 1lp4 1lpu 1lr4 1ymi |
| Related UniProtKB | |
| [21] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 16335523 |
| Journal | Mol Cell Biochem |
| Year | 2005 |
| Volume | 274 |
| Pages | 3-14 |
| Authors | Niefind K, Issinger OG |
| Title | Primary and secondary interactions between CK2alpha and CK2beta lead to ring-like structures in the crystals of the CK2 holoenzyme. |
| Related PDB | |
| Related UniProtKB | |
| [22] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 16342414 |
| Journal | Mol Cell Biochem |
| Year | 2005 |
| Volume | 274 |
| Pages | 163-70 |
| Authors | Poole A, Poore T, Bandhakavi S, McCann RO, Hanna DE, Glover CV |
| Title | A global view of CK2 function and regulation. |
| Related PDB | |
| Related UniProtKB | |
| [23] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 16806200 |
| Journal | FEBS Lett |
| Year | 2006 |
| Volume | 580 |
| Pages | 3948-52 |
| Authors | Salvi M, Sarno S, Marin O, Meggio F, Itarte E, Pinna LA |
| Title | Discrimination between the activity of protein kinase CK2 holoenzyme and its catalytic subunits. |
| Related PDB | |
| Related UniProtKB | |
| [24] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 17524418 |
| Journal | J Mol Biol |
| Year | 2007 |
| Volume | 370 |
| Pages | 427-38 |
| Authors | Niefind K, Yde CW, Ermakova I, Issinger OG |
| Title | Evolved to be active: sulfate ions define substrate recognition sites of CK2alpha and emphasise its exceptional role within the CMGC family of eukaryotic protein kinases. |
| Related PDB | 2pvr |
| Related UniProtKB | |
| [25] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 18291315 |
| Journal | Chem Biol |
| Year | 2008 |
| Volume | 15 |
| Pages | 111-7 |
| Authors | Raaf J, Brunstein E, Issinger OG, Niefind K |
| Title | The CK2 alpha/CK2 beta interface of human protein kinase CK2 harbors a binding pocket for small molecules. |
| Related PDB | 3h30 3juh |
| Related UniProtKB | |
| [26] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 18242640 |
| Journal | J Mol Biol |
| Year | 2008 |
| Volume | 377 |
| Pages | 1-8 |
| Authors | Raaf J, Klopffleisch K, Issinger OG, Niefind K |
| Title | The catalytic subunit of human protein kinase CK2 structurally deviates from its maize homologue in complex with the nucleotide competitive inhibitor emodin. |
| Related PDB | 3bqc 3c13 |
| Related UniProtKB | |
| [27] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 18824508 |
| Journal | Protein Sci |
| Year | 2008 |
| Volume | 17 |
| Pages | 2180-6 |
| Authors | Raaf J, Brunstein E, Issinger OG, Niefind K |
| Title |
The interaction of CK2alpha and CK2beta, |
| Related PDB | 3eed |
| Related UniProtKB | |
| [28] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 19193990 |
| Journal | Acta Crystallogr Sect F Struct Biol Cryst Commun |
| Year | 2009 |
| Volume | 65 |
| Pages | 75-9 |
| Authors | Nakaniwa T, Kinoshita T, Sekiguchi Y, Tada T, Nakanishi I, Kitaura K, Suzuki Y, Ohno H, Hirasawa A, Tsujimoto G |
| Title | Structure of human protein kinase CK2 alpha 2 with a potent indazole-derivative inhibitor. |
| Related PDB | 3e3b |
| Related UniProtKB | |
| [29] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 19361447 |
| Journal | J Mol Biol |
| Year | 2009 |
| Volume | 386 |
| Pages | 1212-21 |
| Authors | Raaf J, Issinger OG, Niefind K |
| Title |
First inactive conformation of CK2 alpha, |
| Related PDB | 3fwq |
| Related UniProtKB | |
| [30] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 19414254 |
| Journal | Bioorg Med Chem Lett |
| Year | 2009 |
| Volume | 19 |
| Pages | 2920-3 |
| Authors | Sekiguchi Y, Nakaniwa T, Kinoshita T, Nakanishi I, Kitaura K, Hirasawa A, Tsujimoto G, Tada T |
| Title | Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid. |
| Related PDB | 2zjw |
| Related UniProtKB | |
| [31] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 20400536 |
| Journal | FASEB J |
| Year | 2010 |
| Volume | 24 |
| Pages | 3171-85 |
| Authors | Lopez-Ramos M, Prudent R, Moucadel V, Sautel CF, Barette C, Lafanechere L, Mouawad L, Grierson D, Schmidt F, Florent JC, Filippakopoulos P, Bullock AN, Knapp S, Reiser JB, Cochet C |
| Title | New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights. |
| Related PDB | 3mb6 3mb7 |
| Related UniProtKB | |
| [32] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 21093442 |
| Journal | FEBS Lett |
| Year | 2011 |
| Volume | 585 |
| Pages | 104-10 |
| Authors | Ferguson AD, Sheth PR, Basso AD, Paliwal S, Gray K, Fischmann TO, Le HV |
| Title | Structural basis of CX-4945 binding to human protein kinase CK2. |
| Related PDB | 3nga 3nsz |
| Related UniProtKB | |
| [33] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 21241709 |
| Journal | J Mol Biol |
| Year | 2011 |
| Volume | 407 |
| Pages | 1-12 |
| Authors | Bischoff N, Olsen B, Raaf J, Bretner M, Issinger OG, Niefind K |
| Title | Structure of the human protein kinase CK2 catalytic subunit CK2alpha' and interaction thermodynamics with the regulatory subunit CK2beta. |
| Related PDB | 3ofm |
| Related UniProtKB | |
| Comments |
|---|
|
This enzyme forms tetramer composed of two alpha and two beta subunits. This enzyme seems to be homologous to cell division kinase 5 (M00196) and phosphorylase linase (M00198 in EzCatDB), |
| Created | Updated |
|---|---|
| 2004-03-25 | 2011-05-02 |