DB code: S00021

RLCP classification	1.30.300.2 : Hydrolysis
CATH domain	1.10.530.40 : Lysozyme	Catalytic domain
E.C.	3.2.1.17
CSA	206l
M-CSA	206l
MACiE

CATH domain	Related DB codes (homologues)
1.10.530.40 : Lysozyme	S00265

Uniprot Enzyme Name
UniprotKB	Protein name	Synonyms	RefSeq	CAZy	Pfam
P00720	Lysozyme	EC 3.2.1.17 Lysis protein Muramidase Endolysin	NP_049736.1 (Protein) NC_000866.4 (DNA/RNA sequence)	GH24 (Glycoside Hydrolase Family 24)	PF00959 (Phage_lysozyme) [Graphical View]

KEGG enzyme name
lysozyme muramidase globulin G mucopeptide glucohydrolase globulin G1 N,O-diacetylmuramidase lysozyme g L-7001 1,4-N-acetylmuramidase mucopeptide N-acetylmuramoylhydrolase PR1-lysozyme

UniprotKB: Accession Number	Entry name	Activity	Subunit	Subcellular location	Cofactor
P00720	LYS_BPT4	Hydrolysis of (1->4)-beta-linkages between N- acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

KEGG Pathways
Map code	Pathways	E.C.

Compound table
						Substrates			Products			Intermediates
KEGG-id						C00851	C00889	C00001	C00851	C04394	C00140
E.C.
Compound						Chitodextrin	Peptidoglycan	H2O	Chitodextrin	Peptidoglycan(N-acetyl-D-glucosamine)	N-Acetyl-D-glucosamine
Type						amide group,polysaccharide	amino acids,amide group,amine group,carbohydrate,peptide/protein,polysaccharide	H2O	amide group,polysaccharide	amino acids,amide group,amine group,carbohydrate,lipid,peptide/protein,polysaccharide	amide group,carbohydrate
ChEBI								15377 15377		8006 8006	506227 506227
PubChem								22247451 962 22247451 962		5462260 5462260	439174 439174
102lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
103lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
104lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
104lB						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
107lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
108lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
109lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
110lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
111lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
112lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
113lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
114lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
115lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
116lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
116lB						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
116lC						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
116lD						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
118lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
119lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
120lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
122lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
123lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
125lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
126lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
127lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
128lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
129lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
130lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
131lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
137lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
137lB						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
138lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
139lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
140lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
141lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
142lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
143lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
144lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
145lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
146lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
147lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
148lE						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:NAG-AMU-ALA-GLU-API-ALA (chain S:covalent bond with mutated residue Glu26)
149lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
150lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
150lB						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
150lC						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
150lD						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
151lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
152lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
155lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
156lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
157lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
158lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
159lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
160lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
161lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
162lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
163lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
164lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
165lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
166lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
167lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
167lB						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
168lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
168lB						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
168lC						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
168lD						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
168lE						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
169lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
169lB						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
169lC						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
169lD						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
169lE						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
170lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
171lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
172lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
173lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
174lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
174lB						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
175lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
175lB						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
176lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
176lB						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
177lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
178lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
179lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
180lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
180lB						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
181lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
182lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
183lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
184lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
185lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
186lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
187lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
188lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
189lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
190lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
191lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
192lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
195lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
196lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
197lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
198lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
199lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1b6iA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c60A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c61A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c62A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c63A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c64A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c65A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c66A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c67A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c68A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c69A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c6aA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c6bA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c6cA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c6dA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c6eA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c6fA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c6gA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c6hA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c6iA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c6jA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c6kA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c6lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c6mA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c6nA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c6pA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c6qA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c6tA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ctwA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1cu0A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1cu2A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1cu3A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1cu5A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1cu6A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1cupA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1cuqA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1cv0A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1cv1A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1cv3A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1cv4A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1cv5A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1cv6A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1cvkA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1cx6A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1cx7A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1d2wA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1d2yA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1d3fA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1d3jA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1d3mA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1d3nA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1d9wA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1dyaA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1dybA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1dycA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1dydA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1dyeA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1dyfA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1dygA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1epyA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l00A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l01A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l02A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l03A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l04A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l05A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l06A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l07A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l08A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l09A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l10A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l11A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l12A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l13A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l14A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l15A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l16A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l17A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l18A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l19A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l20A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l21A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l22A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l23A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l24A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l25A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l26A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l27A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l28A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l29A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l30A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l31A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l32A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l33A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l34A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l35A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l36A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l37A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l38A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l39A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l40A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l41A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l42A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l43A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l44A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l45A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l46A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l47A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l48A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l49A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l50A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l51A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l52A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l53A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l54A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l55A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l56A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l57A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l58A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l59A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l60A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l61A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l62A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l63A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l64A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l65A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l66A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l67A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l68A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l69A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l70A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l71A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l72A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l73A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l74A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l75A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l76A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l77A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l79A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l80A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l81A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l82A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l83A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l84A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l85A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l86A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l87A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l88A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l89A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l90A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l91A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l92A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l93A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l94A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l95A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l96A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l97A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l97B						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l98A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1l99A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1lydA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1lyeA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1lyfA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1lygA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1lyhA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1lyiA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1lyjA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1nhbA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1qs5A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1qs9A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1qsbA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1qsqA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1qt3A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1qt4A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1qt5A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1qt6A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1qt7A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1qt8A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1qtbA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1qtcA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1qtdA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1qthA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1qthB						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1qtvA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1qtzA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1qudA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1qugA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1quhA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1quoA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1tlaA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
200lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
201lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
201lB						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
205lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
206lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
209lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
210lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
211lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
212lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
213lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
214lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
215lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
216lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
216lB						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
217lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
218lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
219lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
220lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
221lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
222lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
223lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
224lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
225lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
226lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
227lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
228lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
229lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
230lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
231lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
232lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
233lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
234lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
235lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
236lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
237lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
238lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
239lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
240lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
241lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
242lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
243lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
244lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
245lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
246lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
247lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
248lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
249lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
250lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
251lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
252lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
253lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
254lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
255lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
256lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
257lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
258lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
259lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
260lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
262lA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
262lB						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
2l78A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
2lzmA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
3lzmA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
4lzmA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
5lzmA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
6lzmA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
7lzmA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound

Reference for Active-site residues
resource	references	E.C.
Swiss-prot;LYCV_BPT4;P00720

Active-site residues
PDB						Catalytic residues	Cofactor-binding residues	Modified residues	Main-chain involved in catalysis	Comment
102lA						GLU 11;ASP 20				mutant C54T, C97A, insertion N40-A
103lA						GLU 11;ASP 20				mutant C54T, C97A, insertion N40-SLD
104lA						GLU 11;ASP 20				mutant C54T, C97A, insertion S44-AA
104lB						GLU 11;ASP 20				mutant C54T, C97A, insertion S44-AA
107lA						GLU 11;ASP 20				mutant S44G, C54T, C97A
108lA						GLU 11;ASP 20				mutant S44I, C54T, C97A
109lA						GLU 11;ASP 20				mutant S44K, C54T, C97A
110lA						GLU 11;ASP 20				mutant S44L, C54T, C97A
111lA						GLU 11;ASP 20				mutant S44N, C54T, C97A
112lA						GLU 11;ASP 20				mutant S44P, C54T, C97A
113lA						GLU 11;ASP 20				mutant S44R, C54T, C97A
114lA						GLU 11;ASP 20				mutant S44T, C54T, C97A
115lA						GLU 11;ASP 20				mutant S44V, C54T, C97A
116lA						GLU 11;ASP 20				mutant S44W, C54T, C97A
116lB						GLU 11;ASP 20				mutant S44W, C54T, C97A
116lC						GLU 11;ASP 20				mutant S44W, C54T, C97A
116lD						GLU 11;ASP 20				mutant S44W, C54T, C97A
118lA						GLU 11;ASP 20				mutant C54T, C97A, A130S
119lA						GLU 11;ASP 20				mutant C54T, C97A, A134S
120lA						GLU 11;ASP 20				mutant A41S, C54T, C97A
122lA						GLU 11;ASP 20				mutant C54T, A73S, C97A
123lA						GLU 11;ASP 20				mutant C54T, A82S, C97A
125lA						GLU 11;ASP 20				mutant C54T, C97A, A98S
126lA						GLU 11;ASP 20				mutant C54T, C97A, V149T
127lA						GLU 11;ASP 20				mutant C54T, V75T, C97A
128lA						GLU 11;ASP 20				mutant C54T, V87T, C97A
129lA						GLU 11;ASP 20				mutant C54T, A93T, C97A
130lA						GLU 11;ASP 20				mutant C54T, C97A, T151S
131lA						GLU 11;ASP 20				mutant T26S, C54T, C97A
137lA						GLU 11;ASP 20				mutant S44F, C54T, C97A
137lB						GLU 11;ASP 20				mutant S44F, C54T, C97A
138lA						GLU 11;ASP 20				mutant C54T, A93C, C97A
139lA						GLU 11;ASP 20				mutant C54T, N68C, A93C, C97A
140lA						GLU 11;ASP 20				mutant C54T, C97A, L121A, A129M, F153L
141lA						GLU 11;ASP 20				mutant C54T, C97A, L121A, A129M, V149I
142lA						GLU 11;ASP 20				mutant C54T, C97A, L121A, A129V, L133A, F153L
143lA						GLU 11;ASP 20				mutant C54T, C97A, L121A, A129V, L133M, F153L
144lA						GLU 11;ASP 20				mutant C54T, C97A, L121I, A129L, L133M, F153W
145lA						GLU 11;ASP 20				mutant C54T, C97A, L121I, A129W, L133M
146lA						GLU 11;ASP 20				mutant C54T, C97A, L121M, A129L, L133M, V149I, F153W
147lA						GLU 11;ASP 20				mutant C54T, C97A, L121M, L133V, F153L
148lE						GLU 11;ASP 20				mutant T26E, C54T, C97A
149lA						GLU 11;ASP 20				mutant I3L
150lA						GLU 11;ASP 20				mutant M6I
150lB						GLU 11;ASP 20				mutant M6I
150lC						GLU 11;ASP 20				mutant M6I
150lD						GLU 11;ASP 20				mutant M6I
151lA						GLU 11;ASP 20				mutant T34A, K35A, S36A, P37A
152lA						GLU 11;ASP 20				mutant I3C, I9C, T21C, C54T, T142C, L164C
155lA						GLU 11;ASP 20				mutant C54T, C97A, T115A, S117A
156lA						GLU 11;ASP 20				mutant C54T, A97A, T115A, R119A
157lA						GLU 11;ASP 20				mutant C54T, C97A, T115A, N116A, S117A, R119A, M120A, Q122A, Q123A
158lA						GLU 11;ASP 20				mutant C54T, C97A, S117A, R119A
159lA						GLU 11;ASP 20				mutant C54T, C97A, R119A, Q123A
160lA						GLU 11;ASP 20				mutant C54T, C97A, M120A
161lA						GLU 11;ASP 20				mutant C54T, C97A, N116A
162lA						GLU 11;ASP 20				mutant C54T, C97A, Q122A
163lA						GLU 11;ASP 20				mutant C54T, C97A, Q123A
164lA						GLU 11;ASP 20				mutant C54T, C97A, R119A
165lA						GLU 11;ASP 20				mutant C54T, C97A, S117A
166lA						GLU 11;ASP 20				mutant C54T, C97A, T115A
167lA						GLU 11;ASP 20				mutant I3C, I9C, C54T, L164C
167lB						GLU 11;ASP 20				mutant I3C, I9C, C54T, L164C
168lA						GLU 11;ASP 20				mutant E128A, V131A, N132A, K135A, S136A, R137A
168lB						GLU 11;ASP 20				mutant E128A, V131A, N132A, K135A, S136A, R137A
168lC						GLU 11;ASP 20				mutant E128A, V131A, N132A, K135A, S136A, R137A
168lD						GLU 11;ASP 20				mutant E128A, V131A, N132A, K135A, S136A, R137A
168lE						GLU 11;ASP 20				mutant E128A, V131A, N132A, K135A, S136A, R137A
169lA						GLU 11;ASP 20				mutant E128A, V131A, N132A, K135A, S136A, R137A, Y139A, N140A, Q141A
169lB						GLU 11;ASP 20				mutant E128A, V131A, N132A, K135A, S136A, R137A, Y139A, N140A, Q141A
169lC						GLU 11;ASP 20				mutant E128A, V131A, N132A, K135A, S136A, R137A, Y139A, N140A, Q141A
169lD						GLU 11;ASP 20				mutant E128A, V131A, N132A, K135A, S136A, R137A, Y139A, N140A, Q141A
169lE						GLU 11;ASP 20				mutant E128A, V131A, N132A, K135A, S136A, R137A, Y139A, N140A, Q141A
170lA						GLU 11;ASP 20				mutant C54S, C97S, A146C
171lA						GLU 11;ASP 20				mutant E45A, C54T, C97A
172lA						GLU 11;ASP 20				mutant I3C
173lA						GLU 11;ASP 20				mutant K16E, R119E, K135E, K147E
174lA						GLU 11;ASP 20				mutant T34A, K35A, S36A, P37A, S38D, N40A, S44A, E45A, D47A, K48A, C54T, T97A
174lB						GLU 11;ASP 20				mutant T34A, K35A, S36A, P37A, S38D, N40A, S44A, E45A, D47A, K48A, C54T, T97A
175lA						GLU 11;ASP 20				mutant C54T, R96A, C97A
175lB						GLU 11;ASP 20				mutant C54T, R96A, C97A
176lA						GLU 11;ASP 20				mutant L32T, T34K, K35V, S36D, P37G, S38N, L39S, C54T, C97A
176lB						GLU 11;ASP 20				mutant L32T, T34K, K35V, S36D, P37G, S38N, L39S, C54T, C97A
177lA						GLU 11;ASP 20				mutant C54T, C97A, D127C, R154C
178lA						GLU 11;ASP 20				mutant C54T, C97A, D127C, R154C
179lA						GLU 11;ASP 20				mutant C54A, C97A, D127C, R154C
180lA						GLU 11;ASP 20				mutant T26E, C54T, C97A
180lB						GLU 11;ASP 20				mutant T26E, C54T, C97A
181lA						GLU 11;ASP 20				mutant C54T, C97A, L99A
182lA						GLU 11;ASP 20				mutant C54T, C97A, L99A
183lA						GLU 11;ASP 20				mutant C54T, C97A, L99A
184lA						GLU 11;ASP 20				mutant C54T, C97A, L99A
185lA						GLU 11;ASP 20				mutant C54T, C97A, L99A
186lA						GLU 11;ASP 20				mutant C54T, C97A, L99A
187lA						GLU 11;ASP 20				mutant C54T, C97A, L99A
188lA						GLU 11;ASP 20				mutant C54T, C97A, L99A
189lA						GLU 11;ASP 20				mutant I3L, S38D, A41V, A82P, N116D, V131A, N144D
190lA						GLU 11;ASP 20				mutant N53A, N55A, V57A
191lA						GLU 11;ASP 20				mutant N53A, N55A, V57A, E128A, V131A, N132A
192lA						GLU 11;ASP 20				mutant N40A, S44A, E45A, D47A, K48A, C54T, C97A, D127A, E128A, V131A, N132A
195lA						GLU 11;ASP 20				mutant C54T, C97A, A129L
196lA						GLU 11;ASP 20				mutant C54T, C97A, A129M
197lA						GLU 11;ASP 20				mutant C54T, C97A, A129M, F153A
198lA						GLU 11;ASP 20				mutant C54T, C97A, L121A, A129L
199lA						GLU 11;ASP 20				mutant C54T, C97A, L121A, A129M
1b6iA						GLU 11;ASP 20				mutant C54T, C97A, T21C, K124C
1c60A						GLU 11;ASP 20				mutant C54T, C97A, F153A
1c61A						GLU 11;ASP 20				mutant C54T, C97A, F153A
1c62A						GLU 11;ASP 20				mutant C54T, C97A, F153A
1c63A						GLU 11;ASP 20				mutant C54T, C97A, L121A
1c64A						GLU 11;ASP 20				mutant C54T, C97A, L121A
1c65A						GLU 11;ASP 20				mutant C54T, C97A, L121A
1c66A						GLU 11;ASP 20				mutant C54T, C97A, L121A, L133A
1c67A						GLU 11;ASP 20				mutant C54T, C97A, L121A, L133A
1c68A						GLU 11;ASP 20				mutant C54T, C97A, L121A, L133A
1c69A						GLU 11;ASP 20				mutant C54T, C97A, L133A
1c6aA						GLU 11;ASP 20				mutant C54T, C97A, L133A
1c6bA						GLU 11;ASP 20				mutant C54T, C97A, L133A
1c6cA						GLU 11;ASP 20				mutant C54T, C97A, L99A
1c6dA						GLU 11;ASP 20				mutant C54T, C97A, L99A
1c6eA						GLU 11;ASP 20				mutant C54T, C97A, L99A
1c6fA						GLU 11;ASP 20				mutant C54T, C97A, L99A
1c6gA						GLU 11;ASP 20				mutant C54T, C97A, L99A
1c6hA						GLU 11;ASP 20				mutant C54T, C97A, L99A
1c6iA						GLU 11;ASP 20				mutant C54T, C97A, L99A
1c6jA						GLU 11;ASP 20				mutant C54T, C97A, L99A
1c6kA						GLU 11;ASP 20				mutant C54T, C97A, L99A
1c6lA						GLU 11;ASP 20				mutant C54T, C97A, L99A, F153A
1c6mA						GLU 11;ASP 20				mutant C54T, C97A, L99A, F153A
1c6nA						GLU 11;ASP 20				mutant C54T, C97A, L99A, F153A
1c6pA						GLU 11;ASP 20				mutant C54T, C97A
1c6qA						GLU 11;ASP 20				mutant C54T, C97A
1c6tA						GLU 11;ASP 20				mutant C54T, C97A
1ctwA						GLU 11;ASP 20				mutant I78A
1cu0A						GLU 11;ASP 20				mutant I78M
1cu2A						GLU 11;ASP 20				mutant I84M
1cu3A						GLU 11;ASP 20				mutant V87M
1cu5A						GLU 11;ASP 20				mutant L91M
1cu6A						GLU 11;ASP 20				mutant L91A
1cupA						GLU 11;ASP 20
1cuqA						GLU 11;ASP 20				mutant V103M
1cv0A						GLU 11;ASP 20				mutant F104M
1cv1A						GLU 11;ASP 20				mutant V111M
1cv3A						GLU 11;ASP 20				mutant L121M
1cv4A						GLU 11;ASP 20				mutant L118M
1cv5A						GLU 11;ASP 20				mutant L133M
1cv6A						GLU 11;ASP 20				mutant V149M
1cvkA						GLU 11;ASP 20				mutant L118A
1cx6A						GLU 11;ASP 20
1cx7A						GLU 11;ASP 20
1d2wA						GLU 11;ASP 20
1d2yA						GLU 11;ASP 20
1d3fA						GLU 11;ASP 20
1d3jA						GLU 11;ASP 20
1d3mA						GLU 11;ASP 20
1d3nA						GLU 11;ASP 20
1d9wA						GLU 11;ASP 20
1dyaA						GLU 11;ASP 20				mutant V131D
1dybA						GLU 11;ASP 20				mutant V131G
1dycA						GLU 11;ASP 20				mutant V131I
1dydA						GLU 11;ASP 20				mutant V131L
1dyeA						GLU 11;ASP 20				mutant V131S
1dyfA						GLU 11;ASP 20				mutant V131M
1dygA						GLU 11;ASP 20				mutant V131E
1epyA						GLU 11;ASP 20				mutant T21H, C54T, C97A, Q141H, T142H
1l00A						GLU 11;ASP 20				mutant Q105A
1l01A						GLU 11;ASP 20				mutant T155A, T157I
1l02A						GLU 11;ASP 20				mutant T157A
1l03A						GLU 11;ASP 20				mutant T157C
1l04A						GLU 11;ASP 20				mutant T157D
1l05A						GLU 11;ASP 20				mutant T157D
1l06A						GLU 11;ASP 20				mutant T157E
1l07A						GLU 11;ASP 20				mutant T157F
1l08A						GLU 11;ASP 20				mutant T157G
1l09A						GLU 11;ASP 20				mutant T157H
1l10A						GLU 11;ASP 20				mutant T157I
1l11A						GLU 11;ASP 20				mutant T157I
1l12A						GLU 11;ASP 20				mutant T157N
1l13A						GLU 11;ASP 20				mutant T157R
1l14A						GLU 11;ASP 20				mutant T157S
1l15A						GLU 11;ASP 20				mutant T157V
1l16A						GLU 11;ASP 20				mutant G156D
1l17A						GLU 11;ASP 20				mutant I3V
1l18A						GLU 11;ASP 20				mutant I3Y
1l19A						GLU 11;ASP 20				mutant S38D
1l20A						GLU 11;ASP 20				mutant N144D
1l21A						GLU 11;ASP 20				mutant N55G
1l22A						GLU 11;ASP 20				mutant K124G
1l23A						GLU 11;ASP 20				mutant G77A
1l24A						GLU 11;ASP 20				mutant A82P
1l25A						GLU 11;ASP 20				mutant P86A
1l26A						GLU 11;ASP 20				mutant P86C
1l27A						GLU 11;ASP 20				mutant P86D
1l28A						GLU 11;ASP 20				mutant P86G
1l29A						GLU 11;ASP 20				mutant P86H
1l30A						GLU 11;ASP 20				mutant P86L
1l31A						GLU 11;ASP 20				mutant P86R
1l32A						GLU 11;ASP 20				mutant P86S
1l33A						GLU 11;ASP 20				mutant V131A
1l34A						GLU 11;ASP 20				mutant R96H
1l35A						GLU 11;ASP 20				mutant I3Y, I9C, C54T, C97A, L164C
1l36A						GLU 11;ASP 20				mutant E128A, V131A, N132A
1l37A						GLU 11;ASP 20				mutant T115E
1l38A						GLU 11;ASP 20				mutant Q123E
1l39A						GLU 11;ASP 20				mutant C54T, C97A, N144E
1l40A						GLU 11;ASP 20				mutant C54T, C97A, N144E
1l41A						GLU 11;ASP 20				mutant C54T, K83H, C97A, A112D
1l42A						GLU 11;ASP 20				mutant K16E
1l43A						GLU 11;ASP 20				mutant K16E
1l44A						GLU 11;ASP 20				mutant R119E
1l45A						GLU 11;ASP 20				mutant K135E
1l46A						GLU 11;ASP 20				mutant K147E
1l47A						GLU 11;ASP 20				mutant R154E
1l48A						GLU 11;ASP 20				mutant A98V
1l49A						GLU 11;ASP 20				mutant A98V, T152S
1l50A						GLU 11;ASP 20				mutant A98V, V149C, T152S
1l51A						GLU 11;ASP 20				mutant A98V, V149I, T152S
1l52A						GLU 11;ASP 20				mutant T152S
1l53A						GLU 11;ASP 20				mutant V149C
1l54A						GLU 11;ASP 20				mutant C54T, C97A, M102K
1l55A						GLU 11;ASP 20				mutant C54T, D92N, C97A
1l56A						GLU 11;ASP 20				mutant K60P
1l57A						GLU 11;ASP 20				mutant N116D
1l58A						GLU 11;ASP 20				mutant P143A
1l59A						GLU 11;ASP 20				mutant C54T, C97A, T109N
1l60A						GLU 11;ASP 20				mutant G113A
1l61A						GLU 11;ASP 20				mutant S38N, C54T, C97A
1l62A						GLU 11;ASP 20				mutant C54T, C97A, T109D
1l63A						GLU 11;ASP 20				mutant C54T, C97A
1l64A						GLU 11;ASP 20				mutant N40A, K43A, S44A, E45A, L46A, D47A, K48A, C54T, C97A
1l65A						GLU 11;ASP 20				mutant D47A, C54T, C97A
1l66A						GLU 11;ASP 20				mutant K43A, C54T, C97A
1l67A						GLU 11;ASP 20				mutant L46A, C54T, C97A
1l68A						GLU 11;ASP 20				mutant S44A, C54T, C97A
1l69A						GLU 11;ASP 20				mutant L133A
1l70A						GLU 11;ASP 20				mutant V131A, N132A
1l71A						GLU 11;ASP 20				mutant E128A, V131A
1l72A						GLU 11;ASP 20				mutant D127A, E128A
1l73A						GLU 11;ASP 20				mutant D127A, E128A, V131A, N132A
1l74A						GLU 11;ASP 20				mutant E128A, V131A, N132A, L133A
1l75A						GLU 11;ASP 20				mutant D127A, E128A, V131A, N132A, L133A
1l76A						GLU 11;ASP 20				mutant C54T, D72P, C97A
1l77A						GLU 11;ASP 20				mutant C54T, C97A, M102L
1l79A						GLU 11;ASP 20				mutant C54T, C97A, L99F, V111I
1l80A						GLU 11;ASP 20				mutant C54T, C97A, L99F, M102L, V111I
1l81A						GLU 11;ASP 20				mutant C54T, C97A, L99F, M102L, F153L
1l82A						GLU 11;ASP 20				mutant C54T, C97A, L99F, M102L, V111I, F153L
1l83A						GLU 11;ASP 20				mutant C54T, C97A, L99A
1l84A						GLU 11;ASP 20				mutant C54T, C97A, L99A, F153A
1l85A						GLU 11;ASP 20				mutant C54T, C97A, F153A
1l86A						GLU 11;ASP 20				mutant C54T, C97A, F153I
1l87A						GLU 11;ASP 20				mutant C54T, C97A, F153L
1l88A						GLU 11;ASP 20				mutant C54T, C97A, F153M
1l89A						GLU 11;ASP 20				mutant C54T, C97A, L99A, F153A
1l90A						GLU 11;ASP 20				mutant C54T, C97A, L99A
1l91A						GLU 11;ASP 20				mutant C54T, C97A, L99F
1l92A						GLU 11;ASP 20				mutant C54T, C97A, L99I
1l93A						GLU 11;ASP 20				mutant C54T, C97A, L99M
1l94A						GLU 11;ASP 20				mutant C54T, C97A, L99V
1l95A						GLU 11;ASP 20				mutant C54T, C97A, F153V
1l96A						GLU 11;ASP 20				mutant I3P
1l97A						GLU 11;ASP 20				mutant I3P
1l97B						GLU 11;ASP 20				mutant I3P
1l98A						GLU 11;ASP 20				mutant Q105E
1l99A						GLU 11;ASP 20				mutant Q105G
1lydA						GLU 11;ASP 20				mutant
1lyeA						GLU 11;ASP 20				mutant C54T, T59V, C97A
1lyfA						GLU 11;ASP 20				mutant C54T, T59S, C97A
1lygA						GLU 11;ASP 20				mutant C54T, T59N, C97A
1lyhA						GLU 11;ASP 20				mutant C54T, T59G, C97A
1lyiA						GLU 11;ASP 20				mutant C54T, T59D, C97A
1lyjA						GLU 11;ASP 20				mutant C54T, T59A, C97A
1nhbA						GLU 11;ASP 20				mutant C54T, C97A, L99A
1qs5A						GLU 11;ASP 20
1qs9A						GLU 11;ASP 20
1qsbA						GLU 11;ASP 20
1qsqA						GLU 11;ASP 20
1qt3A						GLU 11;ASP 20				mutant T26D, C54T, C97A
1qt4A						GLU 11;ASP 20				mutant T26Q, C54T, C97A
1qt5A						GLU 11;				mutant D20E, C54T, C97A
1qt6A						;ASP 20				mutant E11H, C54T, C97A
1qt7A						;ASP 20				mutant E11N, C54T, C97A
1qt8A						GLU 11;ASP 20				mutant T26H, C54T, C97A
1qtbA						GLU 11;ASP 20
1qtcA						GLU 11;ASP 20
1qtdA						GLU 11;ASP 20
1qthA						GLU 11;ASP 20
1qthB						GLU 11;ASP 20
1qtvA						GLU 11;ASP 20				mutant T26E, C54T, C97A
1qtzA						GLU 11;				mutant D20C, C54T, C97A
1qudA						GLU 11;ASP 20				mutant L99G
1qugA						GLU 11;ASP 20				mutant E108V
1quhA						GLU 11;ASP 20				mutant L99G, E108V
1quoA						GLU 11;ASP 20				mutant L99A, E108V
1tlaA						GLU 11;ASP 20				mutant C54T, C97A, S117F
200lA						GLU 11;ASP 20				mutant C54T, C97A, L121A
201lA						GLU 11;ASP 20				mutant C54T, C97A, insertion K48-HP
201lB						GLU 11;ASP 20				mutant C54T, C97A, insertion K48-HP
205lA						GLU 11;ASP 20				mutant C54T, C97A, insertion S44-AAA
206lA						GLU 11;ASP 20				mutant A42S, C54T, C97A
209lA						GLU 11;ASP 20				mutant C54T, C97A, insertion A73-AAA
210lA						GLU 11;ASP 20				mutant C54T, C97A, deletion A73
211lA						GLU 11;ASP 20				mutant C54T, C97A, insertion E108-A
212lA						GLU 11;ASP 20				mutant C54T, C97A, insertion L164-AAAA
213lA						GLU 11;ASP 20				mutant C54T, C97A, insertion N140-A
214lA						GLU 11;ASP 20				mutant C54T, C97A, insertion R119-A
215lA						GLU 11;ASP 20				mutant C54T, C97A, insertion T115-A
216lA						GLU 11;ASP 20				mutant S44W, C54T, C97A
216lB						GLU 11;ASP 20				mutant S44W, C54T, C97A
217lA						GLU 11;ASP 20				mutant S44E, C54T, C97A
218lA						GLU 11;ASP 20				mutant C54T, C97A, insertion V131-A
219lA						GLU 11;ASP 20				mutant C54T, C97A, insertion L164-AAAA
220lA						GLU 11;ASP 20				mutant C54T, C97A, M102A
221lA						GLU 11;ASP 20				mutant A49S, C54T, C97A
222lA						GLU 11;ASP 20				mutant C54T, C97A, M102A
223lA						GLU 11;ASP 20				mutant L133G
224lA						GLU 11;ASP 20				mutant C54T, A93S, C97A
225lA						GLU 11;ASP 20				mutant L133G
226lA						GLU 11;ASP 20				mutant L133G
227lA						GLU 11;ASP 20				mutant C54T, C97A, F104A
228lA						GLU 11;ASP 20				mutant C54T, C97A, F104A
229lA						GLU 11;ASP 20				mutant C54T, R95A, C97A
230lA						GLU 11;ASP 20				mutant M6L, C54T, C97A
231lA						GLU 11;ASP 20				mutant C54T, C97A, M106K
232lA						GLU 11;ASP 20				mutant C54T, C97A, M120K
233lA						GLU 11;ASP 20				mutant C54T, C97A, M120L
234lA						GLU 11;ASP 20				mutant C54T, C97A, M106L
235lA						GLU 11;ASP 20				mutant C54T, C97A, V111A
236lA						GLU 11;ASP 20				mutant C54T, V87A, C97A
237lA						GLU 11;ASP 20				mutant C54T, C97A, V149A
238lA						GLU 11;ASP 20				mutant C54T, C97A, V103A
239lA						GLU 11;ASP 20				mutant I17A, C54T, C97A
240lA						GLU 11;ASP 20				mutant I27A, C54T, C97A
241lA						GLU 11;ASP 20				mutant I29A, C54T, C97A
242lA						GLU 11;ASP 20				mutant I50A, C54T, C97A
243lA						GLU 11;ASP 20				mutant C54T, I58A, C97A
244lA						GLU 11;ASP 20				mutant C54T, C97A, I100A
245lA						GLU 11;ASP 20				mutant M6A, C54T, C97A
246lA						GLU 11;ASP 20				mutant C54T, F67A, C97A
247lA						GLU 11;ASP 20				mutant C54T, L84A, C97A
248lA						GLU 11;ASP 20				mutant I27A, I29A, C54T, C97A
249lA						GLU 11;ASP 20				mutant I27A, C54T, I58A, C97A
250lA						GLU 11;ASP 20				mutant I29A, C54T, I58A, C97A
251lA						GLU 11;ASP 20				mutant C54T, C97A, L121A, L133A
252lA						GLU 11;ASP 20				mutant C54T, C97A, M102A, M106A
253lA						GLU 11;				mutant D20A, C54T, C97A
254lA						GLU 11;				mutant D20S, C54T, C97A
255lA						GLU 11;				mutant D20N, C54T, C97A
256lA						GLU 11;ASP 20				mutant M6I
257lA						GLU 11;ASP 20				mutant C54T, C97A
258lA						GLU 11;ASP 20				mutant
259lA						GLU 11;ASP 20				mutant T21H, C54T, C97A, T142H
260lA						GLU 11;ASP 20				mutant T21H, C54T, C97A, T142H
262lA						GLU 11;ASP 20				mutant L39I, insertion I50-NAAKSELDKAI
262lB						GLU 11;ASP 20				mutant L39I, insertion I50-NAAKSELDKAI
2l78A						GLU 11;ASP 20				mutant C54T, C97A, V111I
2lzmA						GLU 11;ASP 20				mutant
3lzmA						GLU 11;ASP 20				mutant
4lzmA						GLU 11;ASP 20				mutant
5lzmA						GLU 11;ASP 20				mutant
6lzmA						GLU 11;ASP 20				mutant
7lzmA						GLU 11;ASP 20				mutant

References for Catalytic Mechanism
References	Sections	No. of steps in catalysis
[3]
[4]
[24]	Fig.1, p.9461-9463	2
[50]	Fig.3
[52]	p.6787
[59]
[61]	Fig.3, p.1007
[64]	Fig.2, p.58
[77]	Fig.4, p.8951-8953

References
[1]
Resource
Comments	X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
Medline ID	77157239
PubMed ID	322662
Journal	Biochem Biophys Res Commun
Year	1977
Volume	75
Pages	265-70
Authors	Remington SJ, Eyck LF, Matthews BW
Title	Atomic coordinates for T4 phage lysozyme.
Related PDB
Related UniProtKB	P00720
[2]
Resource
Comments
Medline ID
PubMed ID	7308203
Journal	Eur J Biochem
Year	1981
Volume	119
Pages	589-93
Authors	Kleppe G, Vasstrand E, Jensen HB
Title	The specificity requirements of bacteriophage T4 lysozyme. Involvement of N-acetamido groups.
Related PDB
Related UniProtKB
[3]
Resource
Comments
Medline ID
PubMed ID	7277499
Journal	J Mol Biol
Year	1981
Volume	147
Pages	523-43
Authors	Anderson WF, Grutter MG, Remington SJ, Weaver LH, Matthews BW
Title	Crystallographic determination of the mode of binding of oligosaccharides to T4 bacteriophage lysozyme: implications for the mechanism of catalysis.
Related PDB
Related UniProtKB
[4]
Resource
Comments
Medline ID
PubMed ID	7207627
Journal	Nature
Year	1981
Volume	290
Pages	334-5
Authors	Matthews BW, Grutter MG, Anderson WF, Remington SJ
Title	Common precursor of lysozymes of hen egg-white and bacteriophage T4.
Related PDB
Related UniProtKB
[5]
Resource
Comments
Medline ID
PubMed ID	7077670
Journal	J Mol Biol
Year	1982
Volume	154
Pages	525-35
Authors	Grutter MG, Matthews BW
Title	Amino acid substitutions far from the active site of bacteriophage T4 lysozyme reduce catalytic activity and suggest that the C-terminal lobe of the enzyme participates in substrate binding.
Related PDB
Related UniProtKB
[6]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	3680274
Journal	J Biol Chem
Year	1987
Volume	262
Pages	16858-64
Authors	Gray TM, Matthews BW
Title	Structural analysis of the temperature-sensitive mutant of bacteriophage T4 lysozyme, glycine 156----aspartic acid.
Related PDB	1l16
Related UniProtKB
[7]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	3681997
Journal	J Mol Biol
Year	1987
Volume	197
Pages	315-29
Authors	Grutter MG, Gray TM, Weaver LH, Wilson TA, Matthews BW
Title	Structural studies of mutants of the lysozyme of bacteriophage T4. The temperature-sensitive mutant protein Thr157----Ile.
Related PDB	1l01 1l10
Related UniProtKB
[8]
Resource
Comments	X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS).
Medline ID	87226186
PubMed ID	3586019
Journal	J Mol Biol
Year	1987
Volume	193
Pages	189-99
Authors	Weaver LH, Matthews BW
Title	Structure of bacteriophage T4 lysozyme refined at 1.7 A resolution.
Related PDB	2lzm
Related UniProtKB	P00720
[9]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	3118211
Journal	Nature
Year	1987
Volume	330
Pages	41-6
Authors	Alber T, Sun DP, Wilson K, Wozniak JA, Cook SP, Matthews BW
Title	Contributions of hydrogen bonds of Thr 157 to the thermodynamic stability of phage T4 lysozyme.
Related PDB	1l02 1l03 1l04 1l05 1l06 1l07 1l08 1l09 1l11 1l12 1l13 1l14 1l15 1l14
Related UniProtKB
[10]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	3477797
Journal	Proc Natl Acad Sci U S A
Year	1987
Volume	84
Pages	6663-7
Authors	Matthews BW, Nicholson H, Becktel WJ
Title	Enhanced protein thermostability from site-directed mutations that decrease the entropy of unfolding.
Related PDB	1l23 1l24
Related UniProtKB
[11]
Resource
Comments
Medline ID
PubMed ID	3029773
Journal	Proc Natl Acad Sci U S A
Year	1987
Volume	84
Pages	1244-8
Authors	McIntosh LP, Griffey RH, Muchmore DC, Nielson CP, Redfield AG, Dahlquist FW
Title	Proton NMR measurements of bacteriophage T4 lysozyme aided by 15N isotopic labeling: structural and dynamic studies of larger proteins.
Related PDB
Related UniProtKB
[12]
Resource
Comments	X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF MUTANT ILE-3.
Medline ID	88302415
PubMed ID	3405287
Journal	Nature
Year	1988
Volume	334
Pages	406-10
Authors	Matsumura M, Becktel WJ, Matthews BW
Title	Hydrophobic stabilization in T4 lysozyme determined directly by multiple substitutions of Ile 3.
Related PDB	1l17 1l18
Related UniProtKB	P00720
[13]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	3200317
Journal	Nature
Year	1988
Volume	336
Pages	651-6
Authors	Nicholson H, Becktel WJ, Matthews BW
Title	Enhanced protein thermostability from designed mutations that interact with alpha-helix dipoles.
Related PDB	1l19 1l20
Related UniProtKB
[14]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	3074306
Journal	Protein Eng
Year	1988
Volume	2
Pages	277-82
Authors	Rose DR, Phipps J, Michniewicz J, Birnbaum GI, Ahmed FR, Muir A, Anderson WF, Narang S
Title	Crystal structure of T4-lysozyme generated from synthetic coding DNA expressed in Escherichia coli.
Related PDB	1lyd
Related UniProtKB
[15]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	3277275
Journal	Science
Year	1988
Volume	239
Pages	631-5
Authors	Alber T, Bell JA, Sun DP, Nicholson H, Wozniak JA, Cook S, Matthews BW
Title	Replacements of Pro86 in phage T4 lysozyme extend an alpha-helix but do not alter protein stability.
Related PDB	1l25 1l26 1l27 1l28 1l29 1l30 1l31 1l32
Related UniProtKB
[16]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	2665808
Journal	Biochemistry
Year	1989
Volume	28
Pages	3793-7
Authors	Weaver LH, Gray TM, Grutter MG, Anderson DE, Wozniak JA, Dahlquist FW, Matthews BW
Title	High-resolution structure of the temperature-sensitive mutant of phage lysozyme, Arg 96----His.
Related PDB	1l34
Related UniProtKB
[17]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	2674124
Journal	J Biol Chem
Year	1989
Volume	264
Pages	16059-66
Authors	Matsumura M, Wozniak JA, Sun DP, Matthews BW
Title	Structural studies of mutants of T4 lysozyme that alter hydrophobic stabilization.
Related PDB	3lzm
Related UniProtKB
[18]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	2511328
Journal	J Mol Biol
Year	1989
Volume	210
Pages	181-93
Authors	Nicholson H, Soderlind E, Tronrud DE, Matthews BW
Title	Contributions of left-handed helical residues to the structure and stability of bacteriophage T4 lysozyme.
Related PDB	1l21 1l22 1l33
Related UniProtKB
[19]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	2916125
Journal	Science
Year	1989
Volume	243
Pages	792-4
Authors	Matsumura M, Matthews BW
Title	Control of enzyme activity by an engineered disulfide bond.
Related PDB	155l 156l 157l 158l 159l 160l 161l 162l 163l 164l 165l 166l
Related UniProtKB
[20]
Resource
Comments	STRUCTURE BY NMR.
Medline ID	91002526
PubMed ID	2207079
Journal	Biochemistry
Year	1990
Volume	29
Pages	6341-62
Authors	McIntosh LP, Wand AJ, Lowry DF, Redfield AG, Dahlquist FW
Title	Assignment of the backbone 1H and 15N NMR resonances of bacteriophage T4 lysozyme.
Related PDB
Related UniProtKB	P00720
[21]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	2334683
Journal	Biochemistry
Year	1990
Volume	29
Pages	2592-8
Authors	Pjura PE, Matsumura M, Wozniak JA, Matthews BW
Title	Structure of a thermostable disulfide-bridge mutant of phage T4 lysozyme shows that an engineered cross-link in a flexible region does not increase the rigidity of the folded protein.
Related PDB	1l35
Related UniProtKB
[22]
Resource
Comments	X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF MUTANT.
Medline ID	91043097
PubMed ID	2234094
Journal	Nature
Year	1990
Volume	348
Pages	263-6
Authors	Faber HR, Matthews BW
Title	A mutant T4 lysozyme displays five different crystal conformations.
Related PDB	256l
Related UniProtKB	P00720
[23]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	1747370
Journal	Biochemistry
Year	1991
Volume	30
Pages	11521-9
Authors	Dao-pin S, Anderson DE, Baase WA, Dahlquist FW, Matthews BW
Title	Structural and thermodynamic consequences of burying a charged residue within the hydrophobic core of T4 lysozyme.
Related PDB	1l54
Related UniProtKB
[24]
Resource
Comments
Medline ID
PubMed ID	1892846
Journal	Biochemistry
Year	1991
Volume	30
Pages	9457-63
Authors	Hardy LW, Poteete AR
Title	Reexamination of the role of Asp20 in catalysis by bacteriophage T4 lysozyme.
Related PDB
Related UniProtKB
[25]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	1911773
Journal	Biochemistry
Year	1991
Volume	30
Pages	9816-28
Authors	Nicholson H, Anderson DE, Dao-pin S, Matthews BW
Title	Analysis of the interaction between charged side chains and the alpha-helix dipole using designed thermostable mutants of phage T4 lysozyme.
Related PDB	1l55 1l57 1l59 1l61 1l62 1l63
Related UniProtKB
[26]
Resource
Comments
Medline ID
PubMed ID	1991123
Journal	Biochemistry
Year	1991
Volume	30
Pages	1425-32
Authors	Poteete AR, Sun DP, Nicholson H, Matthews BW
Title	Second-site revertants of an inactive T4 lysozyme mutant restore activity by restructuring the active site cleft.
Related PDB
Related UniProtKB
[27]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	1854726
Journal	Biochemistry
Year	1991
Volume	30
Pages	7142-53
Authors	Sun DP, Sauer U, Nicholson H, Matthews BW
Title	Contributions of engineered surface salt bridges to the stability of T4 lysozyme determined by directed mutagenesis.
Related PDB	1l37 1l38 1l39 1l40 1l41
Related UniProtKB
[28]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	1998663
Journal	Biochemistry
Year	1991
Volume	30
Pages	2012-7
Authors	Zhang XJ, Baase WA, Matthews BW
Title	Toward a simplification of the protein folding problem: a stabilizing polyalanine alpha-helix engineered in T4 lysozyme.
Related PDB	1l36
Related UniProtKB
[29]
Resource
Comments
Medline ID
PubMed ID	1814699
Journal	Ciba Found Symp
Year	1991
Volume	161
Pages	91-103; discussion 103-7
Authors	Kollman PA, Daggett V, Dang LX
Title	The application of computational methods to the study of enzyme catalysis by triose-phosphate isomerase and stabilities of variants of bacteriophage T4 lysozyme.
Related PDB
Related UniProtKB
[30]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	1920439
Journal	J Mol Biol
Year	1991
Volume	221
Pages	647-67
Authors	Daopin S, Alber T, Baase WA, Wozniak JA, Matthews BW
Title	Structural and thermodynamic analysis of the packing of two alpha-helices in bacteriophage T4 lysozyme.
Related PDB	1l48 1l49 1l50 1l51 1l52 1l53
Related UniProtKB
[31]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	1942034
Journal	J Mol Biol
Year	1991
Volume	221
Pages	873-87
Authors	Sun DP, Soderlind E, Baase WA, Wozniak JA, Sauer U, Matthews BW
Title	Cumulative site-directed charge-change replacements in bacteriophage T4 lysozyme suggest that long-range electrostatic interactions contribute little to protein stability.
Related PDB	1l42 1l43 1l44 1l45 1l46 1l47 1l58
Related UniProtKB
[32]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	2062826
Journal	Proteins
Year	1991
Volume	10
Pages	10-21
Authors	Bell JA, Wilson KP, Zhang XJ, Faber HR, Nicholson H, Matthews BW
Title	Comparison of the crystal structure of bacteriophage T4 lysozyme at low, medium, and high ionic strengths.
Related PDB	4lzm 5lzm 6lzm 7lzm
Related UniProtKB
[33]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	1567817
Journal	Biochemistry
Year	1992
Volume	31
Pages	3590-6
Authors	Bell JA, Becktel WJ, Sauer U, Baase WA, Matthews BW
Title	Dissection of helix capping in T4 lysozyme by structural and thermodynamic analysis of six amino acid substitutions at Thr 59.
Related PDB	1lye 1lyf 1lyg 1lyh 1lyi 1lyj
Related UniProtKB
[34]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	1457724
Journal	Biopolymers
Year	1992
Volume	32
Pages	1431-41
Authors	Nicholson H, Tronrud DE, Becktel WJ, Matthews BW
Title	Analysis of the effectiveness of proline substitutions and glycine replacements in increasing the stability of phage T4 lysozyme.
Related PDB	1l56 1l60
Related UniProtKB
[35]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	1733941
Journal	J Biol Chem
Year	1992
Volume	267
Pages	2393-9
Authors	Sauer UH, San DP, Matthews BW
Title	Tolerance of T4 lysozyme to proline substitutions within the long interdomain alpha-helix illustrates the adaptability of proteins to potentially destabilizing lesions.
Related PDB	1l76
Related UniProtKB
[36]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	1404394
Journal	J Mol Biol
Year	1992
Volume	227
Pages	917-33
Authors	Dixon MM, Nicholson H, Shewchuk L, Baase WA, Matthews BW
Title	Structure of a hinge-bending bacteriophage T4 lysozyme mutant, Ile3-->Pro.
Related PDB	1l96 1l97
Related UniProtKB
[37]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	1569571
Journal	J Mol Biol
Year	1992
Volume	224
Pages	1143-59
Authors	Hurley JH, Baase WA, Matthews BW
Title	Design and structural analysis of alternative hydrophobic core packing arrangements in bacteriophage T4 lysozyme.
Related PDB	1l77 1l79 1l80 1l81 1l82 2l78
Related UniProtKB
[38]
Resource
Comments	X-RAY CRYSTALLOGRAPHY OF MUTANT.
Medline ID	92115004
PubMed ID	1731252
Journal	Nature
Year	1992
Volume	355
Pages	371-3
Authors	Eriksson AE, Baase WA, Wozniak JA, Matthews BW
Title	A cavity-containing mutant of T4 lysozyme is stabilized by buried benzene.
Related PDB	1l83 1l84
Related UniProtKB	P00720
[39]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	1570293
Journal	Proc Natl Acad Sci U S A
Year	1992
Volume	89
Pages	3751-5
Authors	Heinz DW, Baase WA, Matthews BW
Title	Folding and function of a T4 lysozyme containing 10 consecutive alanines illustrate the redundancy of information in an amino acid sequence.
Related PDB	1l64 1l65 1l66 1l67 1l68
Related UniProtKB
[40]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	1304882
Journal	Protein Sci
Year	1992
Volume	1
Pages	46-57
Authors	Jacobson RH, Matsumura M, Faber HR, Matthews BW
Title	Structure of a stabilizing disulfide bridge mutant that closes the active-site cleft of T4 lysozyme.
Related PDB	259l 1kni
Related UniProtKB
[41]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	1304917
Journal	Protein Sci
Year	1992
Volume	1
Pages	761-76
Authors	Zhang XJ, Baase WA, Matthews BW
Title	Multiple alanine replacements within alpha-helix 126-134 of T4 lysozyme have independent, additive effects on both structure and stability.
Related PDB	1l69 1l70 1l71 1l72 1l73 1l74 1l75
Related UniProtKB
[42]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	8218201
Journal	Biochemistry
Year	1993
Volume	32
Pages	11363-73
Authors	Blaber M, Lindstrom JD, Gassner N, Xu J, Heinz DW, Matthews BW
Title	Energetic cost and structural consequences of burying a hydroxyl group within the core of a protein determined from Ala-->Ser and Val-->Thr substitutions in T4 lysozyme.
Related PDB	118l 119l 120l 122l 123l 125l 126l 127l 128l 206l 221l 224l
Related UniProtKB
[43]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	8433369
Journal	J Mol Biol
Year	1993
Volume	229
Pages	747-69
Authors	Eriksson AE, Baase WA, Matthews BW
Title	Similar hydrophobic replacements of Leu99 and Phe153 within the core of T4 lysozyme have different structural and thermodynamic consequences.
Related PDB	1l85 1l86 1l87 1l88 1l89 1l90 1l91 1l92 1l93 1l94 1l95
Related UniProtKB
[44]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	8429913
Journal	Nature
Year	1993
Volume	361
Pages	561-4
Authors	Heinz DW, Baase WA, Dahlquist FW, Matthews BW
Title	How amino-acid insertions are allowed in an alpha-helix of T4 lysozyme.
Related PDB	102l 103l 104l 201l 205l
Related UniProtKB
[45]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	8401213
Journal	Protein Sci
Year	1993
Volume	2
Pages	1285-90
Authors	Anderson DE, Hurley JH, Nicholson H, Baase WA, Matthews BW
Title	Hydrophobic core repacking and aromatic-aromatic interaction in the thermostable mutant of T4 lysozyme Ser 117-->Phe.
Related PDB	1tla
Related UniProtKB
[46]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	8298466
Journal	Protein Sci
Year	1993
Volume	2
Pages	2226-32
Authors	Pjura P, Matthews BW
Title	Structures of randomly generated mutants of T4 lysozyme show that protein stability can be enhanced by relaxation of strain and by improved hydrogen bonding via bound solvent.
Related PDB	129l 130l 131l
Related UniProtKB
[47]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	8460110
Journal	Proteins
Year	1993
Volume	15
Pages	401-12
Authors	Pjura P, McIntosh LP, Wozniak JA, Matthews BW
Title	Perturbation of Trp 138 in T4 lysozyme by mutations at Gln 105 used to correlate changes in structure, stability, solvation, and spectroscopic properties.
Related PDB	1l00 1l98 1l99
Related UniProtKB
[48]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	8259514
Journal	Science
Year	1993
Volume	262
Pages	1715-8
Authors	Baldwin EP, Hajiseyedjavadi O, Baase WA, Matthews BW
Title	The role of backbone flexibility in the accommodation of variants that repack the core of T4 lysozyme.
Related PDB	140l 141l 142l 143l 144l 145l 146l 147l
Related UniProtKB
[49]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	8503008
Journal	Science
Year	1993
Volume	260
Pages	1637-40
Authors	Blaber M, Zhang XJ, Matthews BW
Title	Structural basis of amino acid alpha helix propensity.
Related PDB	107l 108l 109l 110l 111l 112l 113l 114l 115l 116l 137l 216l 217l
Related UniProtKB
[50]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	8266098
Journal	Science
Year	1993
Volume	262
Pages	2030-3
Authors	Kuroki R, Weaver LH, Matthews BW
Title	A covalent enzyme-substrate intermediate with saccharide distortion in a mutant T4 lysozyme.
Related PDB	148l
Related UniProtKB
[51]
Resource
Comments
Medline ID
PubMed ID	7727368
Journal	Biochemistry
Year	1994
Volume	33
Pages	11174-83
Authors	McLeish MJ, Nielsen KJ, Najbar LV, Wade JD, Lin F, Doughty MB, Craik DJ
Title	Conformation of a peptide corresponding to T4 lysozyme residues 59-81 by NMR and CD spectroscopy.
Related PDB
Related UniProtKB
[52]
Resource
Comments
Medline ID
PubMed ID	7961435
Journal	J Bacteriol
Year	1994
Volume	176
Pages	6783-8
Authors	Poteete AR, Hardy LW
Title	Genetic analysis of bacteriophage T4 lysozyme structure and function.
Related PDB
Related UniProtKB
[53]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	8289284
Journal	J Mol Biol
Year	1994
Volume	235
Pages	600-24
Authors	Blaber M, Zhang XJ, Lindstrom JD, Pepiot SD, Baase WA, Matthews BW
Title	Determination of alpha-helix propensity within the context of a folded protein. Sites 44 and 131 in bacteriophage T4 lysozyme.
Related PDB	1dya 1dyb 1dyc 1dyd 1dye 1dyf 1dyg
Related UniProtKB
[54]
Resource
Comments
Medline ID
PubMed ID	8114100
Journal	J Mol Biol
Year	1994
Volume	236
Pages	869-86
Authors	Heinz DW, Baase WA, Zhang XJ, Blaber M, Dahlquist FW, Matthews BW
Title	Accommodation of amino acid insertions in an alpha-helix of T4 lysozyme. Structural and thermodynamic analysis.
Related PDB
Related UniProtKB
[55]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	8177878
Journal	Protein Eng
Year	1994
Volume	7
Pages	301-7
Authors	Heinz DW, Matthews BW
Title	Rapid crystallization of T4 lysozyme by intermolecular disulfide cross-linking.
Related PDB	138l 139l
Related UniProtKB
[56]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	7920248
Journal	Protein Sci
Year	1994
Volume	3
Pages	1031-9
Authors	Zhang XJ, Matthews BW
Title	Conservation of solvent-binding sites in 10 crystal forms of T4 lysozyme.
Related PDB	149l 150l 151l 152l
Related UniProtKB
[57]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	7612599
Journal	Biochemistry
Year	1995
Volume	34
Pages	8576-88
Authors	Morton A, Matthews BW
Title	Specificity of ligand binding in a buried nonpolar cavity of T4 lysozyme: linkage of dynamics and structural plasticity.
Related PDB	181l 182l 183l 184l 185l 186l 187l 188l 1nhb
Related UniProtKB
[58]
Resource
Comments
Medline ID
PubMed ID	7632721
Journal	Biochim Biophys Acta
Year	1995
Volume	1250
Pages	163-70
Authors	Najbar LV, Craik DJ, Wade JD, Lin F, McLeish MJ
Title	CD and NMR determination of the solution structure of a peptide corresponding to T4 lysozyme residues 38-51.
Related PDB
Related UniProtKB
[59]
Resource
Comments
Medline ID
PubMed ID	7823320
Journal	J Mol Biol
Year	1995
Volume	245
Pages	54-68
Authors	Weaver LH, Grutter MG, Matthews BW
Title	The refined structures of goose lysozyme and its complex with a bound trisaccharide show that the "goose-type" lysozymes lack a catalytic aspartate residue.
Related PDB
Related UniProtKB
[60]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	7616572
Journal	J Mol Biol
Year	1995
Volume	250
Pages	527-52
Authors	Zhang XJ, Wozniak JA, Matthews BW
Title	Protein flexibility and adaptability seen in 25 crystal forms of T4 lysozyme.
Related PDB	167l 168l 169l 170l 171l 172l 173l 174l 175l 176l 177l 178l 179l 180l
Related UniProtKB
[61]
Resource
Comments
Medline ID
PubMed ID	7583653
Journal	Nat Struct Biol
Year	1995
Volume	2
Pages	1007-11
Authors	Kuroki R, Weaver LH, Matthews BW
Title	Structure-based design of a lysozyme with altered catalytic activity.
Related PDB
Related UniProtKB
[62]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	7831309
Journal	Proc Natl Acad Sci U S A
Year	1995
Volume	92
Pages	452-6
Authors	Shoichet BK, Baase WA, Kuroki R, Matthews BW
Title	A relationship between protein stability and protein function.
Related PDB	253l 254l 255l
Related UniProtKB
[63]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	8771182
Journal	Protein Eng
Year	1995
Volume	8
Pages	1017-22
Authors	Zhang XJ, Baase WA, Shoichet BK, Wilson KP, Matthews BW
Title	Enhancement of protein stability by the combination of point mutations in T4 lysozyme is additive.
Related PDB	189l
Related UniProtKB
[64]
Resource
Comments
Medline ID
PubMed ID	8958073
Journal	Ann N Y Acad Sci
Year	1996
Volume	799
Pages	56-60
Authors	Morimoto K, Kuroki R, Matthews BW
Title	Control of the catalytic mechanism of an enzyme by amino acid substitution.
Related PDB
Related UniProtKB
[65]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	8676387
Journal	J Mol Biol
Year	1996
Volume	259
Pages	542-59
Authors	Baldwin E, Xu J, Hajiseyedjavadi O, Baase WA, Matthews BW
Title	Thermodynamic and structural compensation in "size-switch" core repacking variants of bacteriophage T4 lysozyme.
Related PDB	195l 196l 197l 198l 199l 200l
Related UniProtKB
[66]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	8976549
Journal	Protein Sci
Year	1996
Volume	5
Pages	2399-415
Authors	Vetter IR, Baase WA, Heinz DW, Xiong JP, Snow S, Matthews BW
Title	Protein structural plasticity exemplified by insertion and deletion mutants in T4 lysozyme.
Related PDB	209l 210l 211l 212l 213l 214l 215l 218l 219l
Related UniProtKB
[67]
Resource
Comments
Medline ID
PubMed ID	9003182
Journal	Biochemistry
Year	1997
Volume	36
Pages	307-16
Authors	Mchaourab HS, Oh KJ, Fang CJ, Hubbell WL
Title	Conformation of T4 lysozyme in solution. Hinge-bending motion and the substrate-induced conformational transition studied by site-directed spin labeling.
Related PDB
Related UniProtKB
[68]
Resource
Comments
Medline ID
PubMed ID	10099305
Journal	Biotechnol Bioeng
Year	1998
Volume	58
Pages	658-62
Authors	Bower CK, Xu Q, McGuire J
Title	Activity losses among T4 lysozyme variants after adsorption to colloidal silica.
Related PDB
Related UniProtKB
[69]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	9514755
Journal	J Mol Biol
Year	1998
Volume	277
Pages	467-85
Authors	Baldwin E, Baase WA, Zhang X, Feher V, Matthews BW
Title	Generation of ligand binding sites in T4 lysozyme by deficiency-creating substitutions.
Related PDB	220l 222l 223l 225l 226l 227l 228l 229l 252l
Related UniProtKB
[70]
Resource
Comments
Medline ID
PubMed ID	9514719
Journal	J Mol Biol
Year	1998
Volume	276
Pages	151-64
Authors	Evrard C, Fastrez J, Declercq JP
Title	Crystal structure of the lysozyme from bacteriophage lambda and its relationship with V and C-type lysozymes.
Related PDB
Related UniProtKB
[71]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	9541409
Journal	Protein Sci
Year	1998
Volume	7
Pages	765-73
Authors	Lipscomb LA, Gassner NC, Snow SD, Eldridge AM, Baase WA, Drew DL, Matthews BW
Title	Context-dependent protein stabilization by methionine-to-leucine substitution shown in T4 lysozyme.
Related PDB	230l 231l 232l 233l 234l
Related UniProtKB
[72]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	9514271
Journal	Protein Sci
Year	1998
Volume	7
Pages	158-77
Authors	Xu J, Baase WA, Baldwin E, Matthews BW
Title	The response of T4 lysozyme to large-to-small substitutions within the core and its relation to the hydrophobic effect.
Related PDB	235l 236l 237l 238l 239l 240l 241l 242l 243l 244l 245l 246l 247l 248l 249l 250l 251l
Related UniProtKB
[73]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	10545167
Journal	Biochemistry
Year	1999
Volume	38
Pages	14451-60
Authors	Gassner NC, Baase WA, Lindstrom JD, Lu J, Dahlquist FW, Matthews BW
Title	Methionine and alanine substitutions show that the formation of wild-type-like structure in the carboxy-terminal domain of T4 lysozyme is a rate-limiting step in folding.
Related PDB	1ctw 1cu0 1cu2 1cu3 1cu5 1cu6 1cup 1cuq 1cv0 1cv1 1cv3 1cv4 1cv5 1cv6 1cvk 1cx7 1qsq
Related UniProtKB
[74]
Resource
Comments
Medline ID
PubMed ID	10074347
Journal	Biochemistry
Year	1999
Volume	38
Pages	2947-55
Authors	Mchaourab HS, Kalai T, Hideg K, Hubbell WL
Title	Motion of spin-labeled side chains in T4 lysozyme: effect of side chain structure.
Related PDB
Related UniProtKB
[75]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	10556025
Journal	J Mol Biol
Year	1999
Volume	294
Pages	17-20
Authors	Gassner NC, Baase WA, Hausrath AC, Matthews BW
Title	Substitution with selenomethionine can enhance the stability of methionine-rich proteins.
Related PDB	1cx6 1d2w 1d2y 1d3f 1d3j 1d3m 1d3n
Related UniProtKB
[76]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	10512706
Journal	J Mol Biol
Year	1999
Volume	292
Pages	1111-20
Authors	Wray JW, Baase WA, Lindstrom JD, Weaver LH, Poteete AR, Matthews BW
Title	Structural analysis of a non-contiguous second-site revertant in T4 lysozyme shows that increasing the rigidity of a protein can enhance its stability.
Related PDB	1qud 1qug 1quh 1quo
Related UniProtKB
[77]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	10430876
Journal	Proc Natl Acad Sci U S A
Year	1999
Volume	96
Pages	8949-54
Authors	Kuroki R, Weaver LH, Matthews BW
Title	Structural basis of the conversion of T4 lysozyme into a transglycosidase by reengineering the active site.
Related PDB	1qt3 1qt4 1qt5 1qt6 1qt7 1qt8 1qtv 1qtz
Related UniProtKB
[78]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	10339544
Journal	Proc Natl Acad Sci U S A
Year	1999
Volume	96
Pages	6078-83
Authors	Sagermann M, Baase WA, Matthews BW
Title	Structural characterization of an engineered tandem repeat contrasts the importance of context and sequence in protein folding.
Related PDB	262l 261l
Related UniProtKB
[79]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	10623513
Journal	J Mol Biol
Year	2000
Volume	295
Pages	127-45
Authors	Liu R, Baase WA, Matthews BW
Title	The introduction of strain and its effects on the structure and stability of T4 lysozyme.
Related PDB	1qs5 1qs9 1qsb 1qtb 1qtc 1qtd 1qth
Related UniProtKB
[80]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	10993735
Journal	J Mol Biol
Year	2000
Volume	302
Pages	955-77
Authors	Quillin ML, Breyer WA, Griswold IJ, Matthews BW
Title	Size versus polarizability in protein-ligand interactions: binding of noble gases within engineered cavities in phage T4 lysozyme.
Related PDB	1c60 1c61 1c62 1c63 1c64 1c65 1c66 1c67 1c68 1c69 1c6a 1c6b 1c6c 1c6d 1c6e 1c6f 1c6g 1c6h 1c6i 1c6j 1c6k 1c6l 1c6m 1c6n 1c6p 1c6q 1c6t
Related UniProtKB
[81]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	10618384
Journal	Proc Natl Acad Sci U S A
Year	2000
Volume	97
Pages	139-44
Authors	Yang G, Cecconi C, Baase WA, Vetter IR, Breyer WA, Haack JA, Matthews BW, Dahlquist FW, Bustamante C
Title	Solid-state synthesis and mechanical unfolding of polymers of T4 lysozyme.
Related PDB	1b6i
Related UniProtKB
[82]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	10835104
Journal	Protein Eng
Year	2000
Volume	13
Pages	313-21
Authors	Wray JW, Baase WA, Ostheimer GJ, Zhang XJ, Matthews BW
Title	Use of a non-rigid region in T4 lysozyme to design an adaptable metal-binding site.
Related PDB	1epy 257l 258l 260l
Related UniProtKB
[83]
Resource
Comments
Medline ID
PubMed ID	11300763
Journal	Biochemistry
Year	2001
Volume	40
Pages	3828-46
Authors	Columbus L, Kalai T, Jeko J, Hideg K, Hubbell WL
Title	Molecular motion of spin labeled side chains in alpha-helices: analysis by variation of side chain structure.
Related PDB
Related UniProtKB
[84]
Resource
Comments
Medline ID
PubMed ID	11341831
Journal	Biochemistry
Year	2001
Volume	40
Pages	5665-73
Authors	Leung AK, Duewel HS, Honek JF, Berghuis AM
Title	Crystal structure of the lytic transglycosylase from bacteriophage lambda in complex with hexa-N-acetylchitohexaose.
Related PDB
Related UniProtKB
[85]
Resource
Comments
Medline ID
PubMed ID	11350172
Journal	J Mol Biol
Year	2001
Volume	308
Pages	745-64
Authors	Goto NK, Skrynnikov NR, Dahlquist FW, Kay LE
Title	What is the average conformation of bacteriophage T4 lysozyme in solution? A domain orientation study using dipolar couplings measured by solution NMR.
Related PDB
Related UniProtKB
[86]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	11316887
Journal	Protein Sci
Year	2001
Volume	10
Pages	1067-78
Authors	Xu J, Baase WA, Quillin ML, Baldwin EP, Matthews BW
Title	Structural and thermodynamic analysis of the binding of solvent at internal sites in T4 lysozyme.
Related PDB	1g06 1g07 1g0g 1g0j 1g0k 1g0l 1g0m 1g0p 1g0q 1g1v 1g1w 1i6s
Related UniProtKB
[87]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	12487988
Journal	Biophys Chem
Year	2002
Volume	101-102
Pages	43-56
Authors	Zhang X, Baase WA, Matthews BW
Title	A helix initiation signal in T4 lysozyme identified by polyalanine mutagenesis.
Related PDB	190l 191l 192l 1d9w
Related UniProtKB
[88]
Resource
Comments
Medline ID
PubMed ID	11996571
Journal	J Am Chem Soc
Year	2002
Volume	124
Pages	5304-14
Authors	Borbat PP, McHaourab HS, Freed JH
Title	Protein structure determination using long-distance constraints from double-quantum coherence ESR: study of T4 lysozyme.
Related PDB
Related UniProtKB
[89]
Resource
Comments
Medline ID
PubMed ID	11841314
Journal	J Am Chem Soc
Year	2002
Volume	124
Pages	1443-51
Authors	Mulder FA, Hon B, Mittermaier A, Dahlquist FW, Kay LE
Title	Slow internal dynamics in proteins: application of NMR relaxation dispersion spectroscopy to methyl groups in a cavity mutant of T4 lysozyme.
Related PDB
Related UniProtKB
[90]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	11884133
Journal	J Mol Biol
Year	2002
Volume	316
Pages	931-40
Authors	Sagermann M, Matthews BW
Title	Crystal structures of a T4-lysozyme duplication-extension mutant demonstrate that the highly conserved beta-sheet region has low intrinsic folding propensity.
Related PDB	1jtm
Related UniProtKB
[91]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	12217695
Journal	J Mol Biol
Year	2002
Volume	322
Pages	339-55
Authors	Wei BQ, Baase WA, Weaver LH, Matthews BW, Shoichet BK
Title	A model binding site for testing scoring functions in molecular docking.
Related PDB	1lgu 1lgw 1lgx 1li2 1li3 1li6
Related UniProtKB
[92]
Resource
Comments
Medline ID
PubMed ID	12364581
Journal	Protein Eng
Year	2002
Volume	15
Pages	669-75
Authors	Machicado C, Bueno M, Sancho J
Title	Predicting the structure of protein cavities created by mutation.
Related PDB
Related UniProtKB
[93]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	11847274
Journal	Protein Sci
Year	2002
Volume	11
Pages	516-21
Authors	Sagermann M, Martensson LG, Baase WA, Matthews BW
Title	A test of proposed rules for helix capping: implications for protein design.
Related PDB	1jqu 1llh
Related UniProtKB
[94]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	12646375
Journal	Biophys Chem
Year	2003
Volume	100
Pages	325-40
Authors	Gassner NC, Baase WA, Mooers BH, Busam RD, Weaver LH, Lindstrom JD, Quillin ML, Matthews BW
Title	Multiple methionine substitutions are tolerated in T4 lysozyme and have coupled effects on folding and stability.
Related PDB	1ks3 1kw5 1kw7 1ky0 1ky1 1l0j 1l0k 1lpy 1lw9 1lwg 1lwk
Related UniProtKB
[95]
Resource
Comments
Medline ID
PubMed ID	12770868
Journal	Biophys J
Year	2003
Volume	84
Pages	3583-93
Authors	Zhang Z, Shi Y, Liu H
Title	Molecular dynamics simulations of peptides and proteins with amplified collective motions.
Related PDB
Related UniProtKB
[96]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	12963380
Journal	J Mol Biol
Year	2003
Volume	332
Pages	741-56
Authors	Mooers BH, Datta D, Baase WA, Zollars ES, Mayo SL, Matthews BW
Title	Repacking the Core of T4 lysozyme by automated design.
Related PDB	1p2l 1p2r 1p36 1p37 1p3n 1p46 1p64 1p6y 1p7s 1pqd 1pqi 1pqj 1pqk 1pqm 1pqo
Related UniProtKB
[97]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	12869697
Journal	Proc Natl Acad Sci U S A
Year	2003
Volume	100
Pages	9191-5
Authors	Sagermann M, Gay L, Matthews BW
Title	Long-distance conformational changes in a protein engineered by modulated sequence duplication
Related PDB	1oyu
Related UniProtKB
[98]
Resource
Comments
Medline ID
PubMed ID	14756565
Journal	Biochemistry
Year	2004
Volume	43
Pages	1296-301
Authors	Sagermann M, Baase WA, Mooers BH, Gay L, Matthews BW
Title	Relocation or duplication of the helix A sequence of T4 lysozyme causes only modest changes in structure but can increase or decrease the rate of folding.
Related PDB
Related UniProtKB

Comments

This enzyme belongs to the glycosidase family-24, which seems to have an inverting mechanism. It converts the configuration of substrate saccharide from equatorial one (or beta-anomer) to axial conformation (or alpha-anomer) (see [77]). According to the literature [61], [64] & [77], the catalytic reaction proceeds in a single displacement mechanism, as follows: (1) Asp20 acts as a general base to acitivate a nearby water molecule. (2) The activated water makes a nucleophilic attack on the C1-atom of glycosidic bond, releasing an alpha-anomer, whilst Glu11 acts as a general acid to protonate the oxygen atom of the glycosidic bond, resulting in the formation of alpha-anomer product. However, the paper [77] suggested that Asp20 is not so essential as Glu11. A counterpart of this residue in Goose lysozyme does not exist (see [59]). In contrast to the wild-type enzyme, the mutant T26H has got a double displacement mechanism, in which the mutated residue, His26, acts as a nucleophile to form a covalent-bonded intermediate, releasing beta-anomer products (see [61], [64] & [77]).

Created	Updated
2004-09-27	2009-02-26