DB code: D00214
| RLCP classification | 1.13.30000.10 : Hydrolysis | |
|---|---|---|
| CATH domain | 2.40.10.10 : Thrombin, subunit H | Catalytic domain |
| 2.40.10.10 : Thrombin, subunit H | Catalytic domain | |
| E.C. | 3.4.21.36 | |
| CSA | ||
| M-CSA | ||
| MACiE | ||
| CATH domain | Related DB codes (homologues) |
|---|---|
| 2.40.10.10 : Thrombin, subunit H | M00139 M00167 D00426 M00133 D00428 D00429 D00430 D00431 D00432 D00433 D00434 D00435 M00227 M00209 D00194 D00197 D00211 D00212 D00216 M00212 D00224 D00497 M00217 M00216 D00528 D00848 D00850 D00851 D00852 D00855 M00152 M00155 M00157 M00181 M00315 M00316 M00317 M00348 M00349 T00074 T00410 T00411 |
| Uniprot Enzyme Name | UniprotKB | Protein name | Synonyms | MEROPS | Pfam | RefSeq |
|---|---|---|---|---|---|
| Q7SIG3 |
Elastase-1
|
EC
3.4.21.36
|
S01.153
(Serine)
|
PF00089
(Trypsin)
[Graphical View] |
|
| P00772 |
Elastase-1
|
EC
3.4.21.36
|
S01.153
(Serine)
|
PF00089
(Trypsin)
[Graphical View] |
NP_998988.1
(Protein)
NM_213823.1 (DNA/RNA sequence) |
| KEGG enzyme name |
|---|
|
pancreatic elastase
pancreatopeptidase E pancreatic elastase I elastase elaszym serine elastase |
| UniprotKB: Accession Number | Entry name | Activity | Subunit | Subcellular location | Cofactor |
|---|---|---|---|---|---|
| Q7SIG3 | ELA1_SALSA | Hydrolysis of proteins, including elastin. Preferential cleavage: Ala-|-Xaa. | Secreted. | Binds 1 calcium ion per subunit. | |
| P00772 | ELA1_PIG | Hydrolysis of proteins, including elastin. Preferential cleavage: Ala-|-Xaa. | Secreted. | Binds 1 calcium ion per subunit. |
| KEGG Pathways | Map code | Pathways | E.C. |
|---|
| Compound table | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cofactors | Substrates | Products | Intermediates | |||||||||||||
| KEGG-id | C00076 | C00017 | C00012 | C00373 | C00001 | C00098 | C00017 | C00012 | I00087 | I00085 | I00086 | |||||
| E.C. | ||||||||||||||||
| Compound | Calcium | Protein | Peptide | Elastin | H2O | Oligopeptide | Protein | Peptide | Peptidyl-tetrahedral intermediate | Acyl-enzyme | Tetrahedral intermediate | |||||
| Type | divalent metal (Ca2+, Mg2+) | peptide/protein | peptide/protein | peptide/protein | H2O | amine group,carboxyl group,peptide/protein | peptide/protein | peptide/protein | ||||||||
| ChEBI |
29108 29108 |
15377 15377 |
||||||||||||||
| PubChem |
271 271 |
439221 439221 |
22247451 962 22247451 962 |
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| 1eltA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1b0eA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:SEI | Unbound | Unbound | |
| 1bmaA01 |
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Unbound | Unbound | Analogue:TFA-LEU-MBH-ISO (chain B) | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1btuA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:2BL | Unbound | |
| 1c1mA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1e34B01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:TPX | Unbound | |
| 1e35B01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:TPX | Unbound | |
| 1e36B01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:TPY | Unbound | |
| 1e37B01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:TPY | Unbound | |
| 1e38B01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:TPY | Unbound | |
| 1eaiA01 |
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Unbound | Bound:LEU_31-MET_32 (chain C) | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1eaiB01 |
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Unbound | Bound:LEU_31-MET_32 (chain D) | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1easA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:TFK | Unbound | Unbound | |
| 1eatA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:TFI | Unbound | Unbound | |
| 1eauA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:BDK | Unbound | Unbound | |
| 1elaA01 |
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Unbound | Unbound | Analogue:TFA-LYS-PRO-ISO (chain B) | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1elbA01 |
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Unbound | Unbound | Analogue:TFA-LYS-LEU-ISO (chain B) | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1elcA01 |
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Unbound | Unbound | Analogue:TFA-LYS-PHE-ISO (chain B) | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1eldE01 |
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Unbound | Unbound | Analogue:TFA-PHE-ALA-ANI (chain I) | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1eleE01 |
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Unbound | Unbound | Analogue:TFA-VAL-ALA-ANI (chain I) | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1elfA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:BAF | Unbound | |
| 1elgA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:BAA | Unbound | |
| 1esaA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1esbA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1estA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:TOS | |
| 1fleE01 |
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Unbound | Bound:ALA_24-MET_25 (chain I) | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1fzzA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:681 | Unbound | Unbound | |
| 1gvkB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:ACE-ASN-PRO-ILE (chain A) | Unbound | |
| 1gwaA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1h9lB01 |
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Unbound | Unbound | Analogue:VAL-GLU-PRO-ILE (chain A) | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1haxB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-bound:VAL-GLU-PRO-ILE (chain A) | Unbound | |
| 1hayB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1hazB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-bound:VAL-GLU-PRO-ILE (chain A) | |
| 1hb0B01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1hv7A01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:616 | Unbound | |
| 1incA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:ICL | Unbound | |
| 1jimA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:ICU | Unbound | |
| 1l0zA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1l1gA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1lkaA01 |
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Unbound | Unbound | Unbound | Unbound | Analogue:ACT | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1lkbA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1lvyA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1mcvA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1mmjN01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:FR1 | Unbound | Unbound | |
| 1nesE01 |
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Unbound | Unbound | Unbound | Unbound | Bound:ACE-ALA-PRO-ALA (chain J) | Unbound | Analogue:ACE-ALA-PRO-ALA (chain I) | Unbound | Unbound | Unbound | |
| 1okxA01 |
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Unbound | Unbound | Analogue:1BO-ALA-THR-THR-LEU-SUJ-CNT-VAL (chain C) | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1okxB01 |
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Unbound | Unbound | Analogue:1BO-ALA-THR-THR-LEU-SUJ-CNT-VAL (chain D) | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qgfA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:TPX | Unbound | |
| 1qixB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-bound:VAL-GLU-PRO-ILE (chain A) | Unbound | |
| 1qnjA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qr3E01 |
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Unbound | Analogue:AIB-ORN-THR-ABA-AA4-PHE-AA6-VAL (chain I) | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1uo6A01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1uvoA01 |
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Unbound | Unbound | Unbound | Unbound | Analogue:ACT | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1uvpA01 |
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Unbound | Unbound | Unbound | Unbound | Analogue:ACT | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2estE01 |
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Unbound | Unbound | Analogue:TFA-LYS-ALA-ANI (chain I) | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3estA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 4estE01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:ACE-ALA-PRO-VAL-FPA (chain I) | Unbound | Unbound | |
| 5estE01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:PHQ-ALA-B2I (chain I) | Unbound | |
| 6estA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 7estE01 |
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Unbound | Unbound | Analogue:TFA-LEU-ALA-ANI (chain I) | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 8estE01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:GIS | Unbound | |
| 9estA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:IBR | Unbound | |
| 1eltA02 |
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Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1b0eA02 |
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Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1bmaA02 |
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Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1btuA02 |
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Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1c1mA02 |
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Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1e34B02 |
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Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1e35B02 |
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Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1e36B02 |
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Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1e37B02 |
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Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1e38B02 |
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Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1eaiA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1eaiB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1easA02 |
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Analogue:_NA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1eatA02 |
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Analogue:_NA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1eauA02 |
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Analogue:_NA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1elaA02 |
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Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1elbA02 |
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Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1elcA02 |
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Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1eldE02 |
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Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1eleE02 |
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Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1elfA02 |
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Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1elgA02 |
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Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1esaA02 |
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Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1esbA02 |
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Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1estA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1fleE02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1fzzA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1gvkB02 |
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Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1gwaA02 |
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Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1h9lB02 |
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Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1haxB02 |
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Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1hayB02 |
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Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1hazB02 |
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Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1hb0B02 |
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Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1hv7A02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1incA02 |
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Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1jimA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1l0zA02 |
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Analogue:_NA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1l1gA02 |
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Analogue:_NA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1lkaA02 |
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Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1lkbA02 |
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Analogue:_NA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1lvyA02 |
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Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1mcvA02 |
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Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1mmjN02 |
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Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1nesE02 |
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Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1okxA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1okxB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qgfA02 |
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Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qixB02 |
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Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qnjA02 |
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Analogue:_NA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qr3E02 |
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Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1uo6A02 |
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Analogue:_NA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1uvoA02 |
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Analogue:_CD | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1uvpA02 |
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Analogue:_CD | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2estE02 |
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|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3estA02 |
|
|
|
|
|
Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 4estE02 |
|
|
|
|
|
Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 5estE02 |
|
|
|
|
|
Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 6estA02 |
|
|
|
|
|
Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 7estE02 |
|
|
|
|
|
Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 8estE02 |
|
|
|
|
|
Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 9estA02 |
|
|
|
|
|
Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| Reference for Active-site residues | ||
|---|---|---|
| resource | references | E.C. |
| Swiss-prot;P00772 & PDB;1bma | ||
| Active-site residues | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Catalytic residues | Cofactor-binding residues | Modified residues | Main-chain involved in catalysis | Comment | |||||
| 1eltA01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1b0eA01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1bmaA01 |
|
|
|
|
|
SER 203 | GLY 201;SER 203 | |||
| 1btuA01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1c1mA01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1e34B01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1e35B01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1e36B01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1e37B01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1e38B01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1eaiA01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1eaiB01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1easA01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1eatA01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1eauA01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1elaA01 |
|
|
|
|
|
SER 203 | GLY 201;SER 203 | |||
| 1elbA01 |
|
|
|
|
|
SER 203 | GLY 201;SER 203 | |||
| 1elcA01 |
|
|
|
|
|
SER 203 | GLY 201;SER 203 | |||
| 1eldE01 |
|
|
|
|
|
SER 203 | GLY 201;SER 203 | |||
| 1eleE01 |
|
|
|
|
|
SER 203 | GLY 201;SER 203 | |||
| 1elfA01 |
|
|
|
|
|
SER 203 | GLY 201;SER 203 | |||
| 1elgA01 |
|
|
|
|
|
SER 203 | GLY 201;SER 203 | |||
| 1esaA01 |
|
|
|
|
|
SER 203 | GLY 201;SER 203 | |||
| 1esbA01 |
|
|
|
|
|
SER 203 | GLY 201;SER 203 | |||
| 1estA01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1fleE01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1fzzA01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1gvkB01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1gwaA01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1h9lB01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1haxB01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1hayB01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1hazB01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1hb0B01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1hv7A01 |
|
|
|
|
|
SER 203 | GLY 201;SER 203 | |||
| 1incA01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1jimA01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1l0zA01 |
|
|
|
|
|
SER 188 | GLY 186;SER 188 | |||
| 1l1gA01 |
|
|
|
|
|
SER 188 | GLY 186;SER 188 | |||
| 1lkaA01 |
|
|
|
|
|
SER 188 | GLY 186;SER 188 | |||
| 1lkbA01 |
|
|
|
|
|
SER 188 | GLY 186;SER 188 | |||
| 1lvyA01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1mcvA01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1mmjN01 |
|
|
|
|
|
SER 188 | GLY 186;SER 188 | |||
| 1nesE01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1okxA01 |
|
|
|
|
|
SER 203 | GLY 201;SER 203 | |||
| 1okxB01 |
|
|
|
|
|
SER 203 | GLY 201;SER 203 | |||
| 1qgfA01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1qixB01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1qnjA01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1qr3E01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1uo6A01 |
|
|
|
|
|
SER 188 | GLY 186;SER 188 | |||
| 1uvoA01 |
|
|
|
|
|
SER 188 | GLY 186;SER 188 | |||
| 1uvpA01 |
|
|
|
|
|
SER 188 | GLY 186;SER 188 | |||
| 2estE01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 3estA01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 4estE01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 5estE01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 6estA01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 7estE01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 8estE01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 9estA01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1eltA02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;THR 75;GLU 77;GLU 80(Calcium binding) | |||
| 1b0eA02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding) | |||
| 1bmaA02 |
|
|
|
|
|
HIS 60;ASP 108 | GLU 74;ASN 76;GLN 79;ASN 81;GLU 84(Calcium binding) | |||
| 1btuA02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding) | |||
| 1c1mA02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASP 77;GLU 80(Calcium binding) | |||
| 1e34B02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding) | |||
| 1e35B02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding) | |||
| 1e36B02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding) | |||
| 1e37B02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding) | |||
| 1e38B02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding) | |||
| 1eaiA02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASP 77;GLU 80(Calcium binding) | |||
| 1eaiB02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASP 77;GLU 80(Calcium binding) | |||
| 1easA02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding) | |||
| 1eatA02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding) | |||
| 1eauA02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding) | |||
| 1elaA02 |
|
|
|
|
|
HIS 60;ASP 108 | GLU 74;ASN 76;GLN 79;ASN 81;GLU 84(Calcium binding) | |||
| 1elbA02 |
|
|
|
|
|
HIS 60;ASP 108 | GLU 74;ASN 76;GLN 79;ASN 81;GLU 84(Calcium binding) | |||
| 1elcA02 |
|
|
|
|
|
HIS 60;ASP 108 | GLU 74;ASN 76;GLN 79;ASN 81;GLU 84(Calcium binding) | |||
| 1eldE02 |
|
|
|
|
|
HIS 60;ASP 108 | GLU 74;ASN 76;GLN 79;ASN 81;GLU 84(Calcium binding) | |||
| 1eleE02 |
|
|
|
|
|
HIS 60;ASP 108 | GLU 74;ASN 76;GLN 79;ASN 81;GLU 84(Calcium binding) | |||
| 1elfA02 |
|
|
|
|
|
HIS 60;ASP 108 | GLU 74;ASN 76;GLN 79;ASN 81;GLU 84(Calcium binding) | |||
| 1elgA02 |
|
|
|
|
|
HIS 60;ASP 108 | GLU 74;ASN 76;GLN 79;ASN 81;GLU 84(Calcium binding) | |||
| 1esaA02 |
|
|
|
|
|
HIS 60;ASP 108 | GLU 74;ASN 76;GLN 79;ASN 81;GLU 84(Calcium binding) | |||
| 1esbA02 |
|
|
|
|
|
HIS 60;ASP 108 | GLU 74;ASN 76;GLN 79;ASN 81;GLU 84(Calcium binding) | |||
| 1estA02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding) | |||
| 1fleE02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding) | |||
| 1fzzA02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASP 77;GLU 80(Calcium binding) | |||
| 1gvkB02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding) | |||
| 1gwaA02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASP 77;GLU 80(Calcium binding) | |||
| 1h9lB02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding) | |||
| 1haxB02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding) | |||
| 1hayB02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding) | |||
| 1hazB02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding) | |||
| 1hb0B02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding) | |||
| 1hv7A02 |
|
|
|
|
|
HIS 60;ASP 108 | GLU 74;ASN 76;GLN 79;ASP 81;GLU 84(Calcium binding) | |||
| 1incA02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding) | |||
| 1jimA02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding) | |||
| 1l0zA02 |
|
|
|
|
|
HIS 45;ASP 93 | GLU 59;ASN 61;GLN 64;ASP 66;GLU 69(Calcium binding) | |||
| 1l1gA02 |
|
|
|
|
|
HIS 45;ASP 93 | GLU 59;ASN 61;GLN 64;ASP 66;GLU 69(Calcium binding) | |||
| 1lkaA02 |
|
|
|
|
|
HIS 45;ASP 93 | GLU 59;ASN 61;GLN 64;ASP 66;GLU 69(Calcium binding) | |||
| 1lkbA02 |
|
|
|
|
|
HIS 45;ASP 93 | GLU 59;ASN 61;GLN 64;ASP 66;GLU 69(Calcium binding) | |||
| 1lvyA02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding) | |||
| 1mcvA02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASP 77;GLU 80(Calcium binding) | |||
| 1mmjN02 |
|
|
|
|
|
HIS 45;ASP 93 | GLU 59;ASN 61;GLN 64;ASP 66;GLU 69(Calcium binding) | |||
| 1nesE02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding) | |||
| 1okxA02 |
|
|
|
|
|
HIS 60;ASP 108 | GLU 74;ASN 76;GLN 79;ASN 81;GLU 84(Calcium binding) | |||
| 1okxB02 |
|
|
|
|
|
HIS 60;ASP 108 | GLU 74;ASN 76;GLN 79;ASN 81;GLU 84(Calcium binding) | |||
| 1qgfA02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding) | |||
| 1qixB02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding) | |||
| 1qnjA02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASP 77;GLU 80(Calcium binding) | |||
| 1qr3E02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding) | |||
| 1uo6A02 |
|
|
|
|
|
HIS 45;ASP 93 | GLU 59;ASN 61;GLN 64;ASP 66;GLU 69(Calcium binding) | |||
| 1uvoA02 |
|
|
|
|
|
HIS 45;ASP 93 | GLU 59;ASN 61;GLN 64;ASP 66;GLU 69(Calcium binding) | |||
| 1uvpA02 |
|
|
|
|
|
HIS 45;ASP 93 | GLU 59;ASN 61;GLN 64;ASP 66;GLU 69(Calcium binding) | |||
| 2estE02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding) | |||
| 3estA02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding) | |||
| 4estE02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding) | |||
| 5estE02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding) | |||
| 6estA02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding) | |||
| 7estE02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding) | |||
| 8estE02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding) | |||
| 9estA02 |
|
|
|
|
|
HIS 57;ASP 102 | GLU 70;ASN 72;GLN 75;ASN 77;GLU 80(Calcium binding) | |||
| References for Catalytic Mechanism | ||
|---|---|---|
| References | Sections | No. of steps in catalysis |
|
[7]
|
Fig.2 | |
|
[10]
|
p.1958 | |
|
[26]
|
Scheme 1, p.7755 | |
|
[30]
|
Fig.3 | |
|
[33]
|
Fig.7 | |
|
[37]
|
Fig.1 | |
|
[38]
|
Scheme 2 | |
|
[42]
|
Scheme 2 | |
|
[43]
|
Fig.1 | |
|
[50]
|
Fig.1 | |
| References | |
|---|---|
| [1] | |
| Resource | |
| Comments |
X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS), |
| Medline ID | |
| PubMed ID | 5415110 |
| Journal | Nature |
| Year | 1970 |
| Volume | 225 |
| Pages | 811-6 |
| Authors | Shotton DM, Watson HC |
| Title | Three-dimensional structure of tosyl-elastase. |
| Related PDB | |
| Related UniProtKB | P00772 |
| [2] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) |
| Medline ID | |
| PubMed ID | 628010 |
| Journal | J Mol Biol |
| Year | 1978 |
| Volume | 118 |
| Pages | 137-208 |
| Authors | Sawyer L, Shotton DM, Campbell JW, Wendell PL, Muirhead H, Watson HC |
| Title | The atomic structure of crystalline porcine pancreatic elastase at 2.5 A resolution: comparisons with the structure of alpha-chymotrypsin. |
| Related PDB | 1est |
| Related UniProtKB | P00772 |
| [3] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 6926029 |
| Journal | J Mol Biol |
| Year | 1982 |
| Volume | 162 |
| Pages | 645-58 |
| Authors | Hughes DL, Sieker LC, Bieth J, Dimicoli JL |
| Title | Crystallographic study of the binding of a trifluoroacetyl dipeptide anilide inhibitor with elastase. |
| Related PDB | 2est |
| Related UniProtKB | |
| [4] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | |
| Journal | J Am Chem Soc |
| Year | 1985 |
| Volume | 107 |
| Pages | 4091-3 |
| Authors | Meyer EF Jr, Presta LG, Radhakrishnan R |
| Title | Stereospecific reaction of 3-methoxy-4-chloro-7-aminoisocoumarin with crystalline porcine pancreatic elastase. |
| Related PDB | 1jim |
| Related UniProtKB | |
| [5] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 3640831 |
| Journal | J Mol Biol |
| Year | 1986 |
| Volume | 189 |
| Pages | 533-9 |
| Authors | Meyer EF Jr, Radhakrishnan R, Cole GM, Presta LG |
| Title | Structure of the product complex of acetyl-Ala-Pro-Ala with porcine pancreatic elastase at 1.65 A resolution. |
| Related PDB | 1nes |
| Related UniProtKB | |
| [6] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 3504964 |
| Journal | J Comput Aided Mol Des |
| Year | 1987 |
| Volume | 1 |
| Pages | 211-7 |
| Authors | Lesyng B, Meyer EF Jr |
| Title | Energy minimization and molecular dynamics studies of Asn-102 elastase. |
| Related PDB | |
| Related UniProtKB | |
| [7] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 3430613 |
| Journal | J Mol Biol |
| Year | 1987 |
| Volume | 198 |
| Pages | 417-24 |
| Authors | Radhakrishnan R, Presta LG, Meyer EF Jr, Wildonger R |
| Title | Crystal structures of the complex of porcine pancreatic elastase with two valine-derived benzoxazinone inhibitors. |
| Related PDB | 1inc |
| Related UniProtKB | |
| [8] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 3271103 |
| Journal | Acta Crystallogr B |
| Year | 1988 |
| Volume | 44 |
| Pages | 26-38 |
| Authors | Meyer E, Cole G, Radhakrishnan R, Epp O |
| Title | Structure of native porcine pancreatic elastase at 1.65 A resolutions. |
| Related PDB | 3est |
| Related UniProtKB | |
| [9] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 3349061 |
| Journal | Biochemistry |
| Year | 1988 |
| Volume | 27 |
| Pages | 725-30 |
| Authors | Meyer EF Jr, Clore GM, Gronenborn AM, Hansen HA |
| Title | Analysis of an enzyme-substrate complex by X-ray crystallography and transferred nuclear Overhauser enhancement measurements: porcine pancreatic elastase and a hexapeptide. |
| Related PDB | |
| Related UniProtKB | |
| [10] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 2655701 |
| Journal | Biochemistry |
| Year | 1989 |
| Volume | 28 |
| Pages | 1951-63 |
| Authors | Bode W, Meyer E Jr, Powers JC |
| Title |
Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, |
| Related PDB | |
| Related UniProtKB | |
| [11] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 2611205 |
| Journal | Biochemistry |
| Year | 1989 |
| Volume | 28 |
| Pages | 7610-7 |
| Authors | Takahashi LH, Radhakrishnan R, Rosenfield RE Jr, Meyer EF Jr |
| Title | Crystallographic analysis of the inhibition of porcine pancreatic elastase by a peptidyl boronic acid: structure of a reaction intermediate. |
| Related PDB | 5est |
| Related UniProtKB | |
| [12] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 2930798 |
| Journal | Biochim Biophys Acta |
| Year | 1989 |
| Volume | 995 |
| Pages | 201-3 |
| Authors | Fitzpatrick PF |
| Title | Identification of the rate-limiting step in serine proteinases from the effect of temperature on steady-state kinetics. |
| Related PDB | |
| Related UniProtKB | |
| [13] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | |
| Journal | J Am Chem Soc |
| Year | 1989 |
| Volume | 111 |
| Pages | 3368-74 |
| Authors | Takahashi LH, Radhakrishnan R, Rosenfieldjunior RE, Meyer EF Jr, Trainor DA |
| Title |
Crystal structure of the covalent complex formed by a peptidyl .alpha.,.alpha.-difluoro-.beta.-keto amide with porcine pancreatic elastase at 1.78 .ANG. |
| Related PDB | 4est |
| Related UniProtKB | |
| [14] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 2337582 |
| Journal | Biochemistry |
| Year | 1990 |
| Volume | 29 |
| Pages | 3108-18 |
| Authors | Powers JC, Oleksyszyn J, Narasimhan SL, Kam CM |
| Title | Reaction of porcine pancreatic elastase with 7-substituted 3-alkoxy-4-chloroisocoumarins: design of potent inhibitors using the crystal structure of the complex formed with 4-chloro-3-ethoxy-7-guanidinoisocoumarin. |
| Related PDB | 8est |
| Related UniProtKB | |
| [15] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 2205243 |
| Journal | Biol Chem Hoppe Seyler |
| Year | 1990 |
| Volume | 371 Suppl |
| Pages | 59-64 |
| Authors | Meyer E, Geller M |
| Title | Irregular elastase complexes: crystallographic and molecular dynamics studies of small inhibitors and water. |
| Related PDB | |
| Related UniProtKB | |
| [16] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 2275978 |
| Journal | Biopolymers |
| Year | 1990 |
| Volume | 30 |
| Pages | 781-96 |
| Authors | Geller M, Carlson-Golab G, Lesyng B, Swanson SM, Meyer EF Jr |
| Title |
Dynamic properties of the first enzymatic reaction steps of porcine pancreatic elastase. |
| Related PDB | |
| Related UniProtKB | |
| [17] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 2354062 |
| Journal | J Mol Recognit |
| Year | 1990 |
| Volume | 3 |
| Pages | 36-44 |
| Authors | de la Sierra IL, Papamichael E, Sakarellos C, Dimicoli JL, Prange T |
| Title |
Interaction of the peptide CF3-Leu-Ala-NH-C6H4-CF3 (TFLA) with porcine pancreatic elastase. |
| Related PDB | 6est 7est |
| Related UniProtKB | |
| [18] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 1998677 |
| Journal | Biochemistry |
| Year | 1991 |
| Volume | 30 |
| Pages | 2175-83 |
| Authors | Vijayalakshmi J, Meyer EF Jr, Kam CM, Powers JC |
| Title | Structural study of porcine pancreatic elastase complexed with 7-amino-3-(2-bromoethoxy)-4-chloroisocoumarin as a nonreactivatable doubly covalent enzyme-inhibitor complex. |
| Related PDB | 9est |
| Related UniProtKB | |
| [19] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8298497 |
| Journal | Biochem Mol Biol Int |
| Year | 1993 |
| Volume | 31 |
| Pages | 685-92 |
| Authors | Bru R, Walde P |
| Title | Catalytic activity of elastase in reverse micelles. |
| Related PDB | |
| Related UniProtKB | |
| [20] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 8049229 |
| Journal | Biochemistry |
| Year | 1994 |
| Volume | 33 |
| Pages | 9285-93 |
| Authors | Ding X, Rasmussen BF, Petsko GA, Ringe D |
| Title | Direct structural observation of an acyl-enzyme intermediate in the hydrolysis of an ester substrate by elastase. |
| Related PDB | 1esa 1esb |
| Related UniProtKB | |
| [21] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8005753 |
| Journal | Int J Pept Protein Res |
| Year | 1994 |
| Volume | 43 |
| Pages | 297-304 |
| Authors | Amour A, Collet A, Dubar C, Reboud-Ravaux M |
| Title | Synthesis and protease-catalyzed hydrolysis of a novel hydrazinopeptide. |
| Related PDB | |
| Related UniProtKB | |
| [22] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 7932559 |
| Journal | J Med Chem |
| Year | 1994 |
| Volume | 37 |
| Pages | 3313-26 |
| Authors | Bernstein PR, Andisik D, Bradley PK, Bryant CB, Ceccarelli C, Damewood JR Jr, Earley R, Edwards PD, Feeney S, Gomes BC, et al |
| Title |
Nonpeptidic inhibitors of human leukocyte elastase. |
| Related PDB | 1eas |
| Related UniProtKB | |
| [23] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 7656008 |
| Journal | Nat Struct Biol |
| Year | 1994 |
| Volume | 1 |
| Pages | 55-8 |
| Authors | Mattos C, Rasmussen B, Ding X, Petsko GA, Ringe D |
| Title | Analogous inhibitors of elastase do not always bind analogously. |
| Related PDB | 1ela 1elb 1elc |
| Related UniProtKB | |
| [24] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF COMPLEX WITH INHIBITOR |
| Medline ID | |
| PubMed ID | 7922044 |
| Journal | Structure |
| Year | 1994 |
| Volume | 2 |
| Pages | 679-89 |
| Authors | Huang K, Strynadka NC, Bernard VD, Peanasky RJ, James MN |
| Title | The molecular structure of the complex of Ascaris chymotrypsin/elastase inhibitor with porcine elastase. |
| Related PDB | 1eai |
| Related UniProtKB | P00772 |
| [25] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 15299762 |
| Journal | Acta Crystallogr D Biol Crystallogr |
| Year | 1995 |
| Volume | 51 |
| Pages | 925-37 |
| Authors | Berglund GI, Willassen NP, Hordvik A, Smalas AO |
| Title | Structure of native pancreatic elastase from North Atlantic salmon at 1.61 A resolution. |
| Related PDB | 1elt |
| Related UniProtKB | |
| [26] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 7779821 |
| Journal | Biochemistry |
| Year | 1995 |
| Volume | 34 |
| Pages | 7749-56 |
| Authors | Ding X, Rasmussen BF, Demuth HU, Ringe D, Steinmetz AC |
| Title | Nature of the inactivation of elastase by N-peptidyl-O-aroyl hydroxylamine as a function of pH. |
| Related PDB | 1elf 1elg |
| Related UniProtKB | |
| [27] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 7880814 |
| Journal | Biochemistry |
| Year | 1995 |
| Volume | 34 |
| Pages | 3193-203 |
| Authors | Mattos C, Giammona DA, Petsko GA, Ringe D |
| Title | Structural analysis of the active site of porcine pancreatic elastase based on the X-ray crystal structures of complexes with trifluoroacetyl-dipeptide-anilide inhibitors. |
| Related PDB | 1eld 1ele |
| Related UniProtKB | |
| [28] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 7837235 |
| Journal | J Med Chem |
| Year | 1995 |
| Volume | 38 |
| Pages | 212-5 |
| Authors | Bernstein PR, Gomes BC, Kosmider BJ, Vacek EP, Williams JC |
| Title |
Nonpeptidic inhibitors of human leukocyte elastase. |
| Related PDB | 1eau |
| Related UniProtKB | |
| [29] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 7837246 |
| Journal | J Med Chem |
| Year | 1995 |
| Volume | 38 |
| Pages | 98-108 |
| Authors | Veale CA, Bernstein PR, Bryant C, Ceccarelli C, Damewood JR Jr, Earley R, Feeney SW, Gomes B, Kosmider BJ, Steelman GB, et al |
| Title |
Nonpeptidic inhibitors of human leukocyte elastase. |
| Related PDB | 1eat |
| Related UniProtKB | |
| [30] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7837244 |
| Journal | J Med Chem |
| Year | 1995 |
| Volume | 38 |
| Pages | 86-97 |
| Authors | Veale CA, Damewood JR Jr, Steelman GB, Bryant C, Gomes B, Williams J |
| Title |
Non-peptidic inhibitors of human leukocyte elastase. |
| Related PDB | |
| Related UniProtKB | |
| [31] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7613461 |
| Journal | Protein Sci |
| Year | 1995 |
| Volume | 4 |
| Pages | 613-21 |
| Authors | Huntington JA, Patston PA, Gettins PG |
| Title |
S-ovalbumin, |
| Related PDB | |
| Related UniProtKB | |
| [32] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 7604279 |
| Journal | Science |
| Year | 1995 |
| Volume | 269 |
| Pages | 66-9 |
| Authors | Peisach E, Casebier D, Gallion SL, Furth P, Petsko GA, Hogan JC Jr, Ringe D |
| Title | Interaction of a peptidomimetic aminimide inhibitor with elastase. |
| Related PDB | 1bma |
| Related UniProtKB | |
| [33] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 8794736 |
| Journal | Biochemistry |
| Year | 1996 |
| Volume | 35 |
| Pages | 11570-6 |
| Authors | Tsunemi M, Matsuura Y, Sakakibara S, Katsube Y |
| Title | Crystal structure of an elastase-specific inhibitor elafin complexed with porcine pancreatic elastase determined at 1.9 A resolution. |
| Related PDB | 1fle |
| Related UniProtKB | |
| [34] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9630949 |
| Journal | Nat Biotechnol |
| Year | 1996 |
| Volume | 14 |
| Pages | 595-9 |
| Authors | Mattos C, Ringe D |
| Title | Locating and characterizing binding sites on proteins. |
| Related PDB | |
| Related UniProtKB | |
| [35] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 15299973 |
| Journal | Acta Crystallogr D Biol Crystallogr |
| Year | 1997 |
| Volume | 53 |
| Pages | 78-92 |
| Authors | Schiltz M, Shepard W, Fourme R, Prange T, de la Fortelle E, Bricogne G |
| Title | High-pressure krypton gas and statistical heavy-atom refinement: a successful combination of tools for macromolecular structure determination. |
| Related PDB | 1lvy |
| Related UniProtKB | |
| [36] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9159490 |
| Journal | J Mol Biol |
| Year | 1997 |
| Volume | 268 |
| Pages | 557-69 |
| Authors | Baker BM, Murphy KP |
| Title | Dissecting the energetics of a protein-protein interaction: the binding of ovomucoid third domain to elastase. |
| Related PDB | |
| Related UniProtKB | |
| [37] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 9187653 |
| Journal | Nat Struct Biol |
| Year | 1997 |
| Volume | 4 |
| Pages | 456-62 |
| Authors | Wilmouth RC, Clifton IJ, Robinson CV, Roach PL, Aplin RT, Westwood NJ, Hajdu J, Schofield CJ |
| Title | Structure of a specific acyl-enzyme complex formed between beta-casomorphin-7 and porcine pancreatic elastase. |
| Related PDB | 1qix |
| Related UniProtKB | |
| [38] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 9860865 |
| Journal | Biochemistry |
| Year | 1998 |
| Volume | 37 |
| Pages | 17506-13 |
| Authors | Wilmouth RC, Westwood NJ, Anderson K, Brownlee W, Claridge TD, Clifton IJ, Pritchard GJ, Aplin RT, Schofield CJ |
| Title | Inhibition of elastase by N-sulfonylaryl beta-lactams: anatomy of a stable acyl-enzyme complex. |
| Related PDB | 1btu |
| Related UniProtKB | |
| [39] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9504720 |
| Journal | Biol Chem |
| Year | 1998 |
| Volume | 379 |
| Pages | 71-4 |
| Authors | Haensler M, Wehofsky N, Gerisch S, Wissmann JD, Jakubke HD |
| Title | Reverse catalysis of elastase from porcine pancreas in frozen aqueous systems. |
| Related PDB | |
| Related UniProtKB | |
| [40] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 9651152 |
| Journal | J Med Chem |
| Year | 1998 |
| Volume | 41 |
| Pages | 2461-80 |
| Authors | Cregge RJ, Durham SL, Farr RA, Gallion SL, Hare CM, Hoffman RV, Janusz MJ, Kim HO, Koehl JR, Mehdi S, Metz WA, Peet NP, Pelton JT, Schreuder HA, Sunder S, Tardif C |
| Title |
Inhibition of human neutrophil elastase. |
| Related PDB | 1b0e |
| Related UniProtKB | |
| [41] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 9443341 |
| Journal | Proteins |
| Year | 1998 |
| Volume | 30 |
| Pages | 61-73 |
| Authors | Prange T, Schiltz M, Pernot L, Colloc'h N, Longhi S, Bourguet W, Fourme R |
| Title | Exploring hydrophobic sites in proteins with xenon or krypton. |
| Related PDB | 1c1m |
| Related UniProtKB | |
| [42] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 10387042 |
| Journal | Biochemistry |
| Year | 1999 |
| Volume | 38 |
| Pages | 7989-98 |
| Authors | Wilmouth RC, Kassamally S, Westwood NJ, Sheppard RJ, Claridge TD, Aplin RT, Wright PA, Pritchard GJ, Schofield CJ |
| Title | Mechanistic insights into the inhibition of serine proteases by monocyclic lactams. |
| Related PDB | 1qgf |
| Related UniProtKB | |
| [43] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10455164 |
| Journal | J Biol Chem |
| Year | 1999 |
| Volume | 274 |
| Pages | 24901-5 |
| Authors | Taylor P, Anderson V, Dowden J, Flitsch SL, Turner NJ, Loughran K, Walkinshaw MD |
| Title | Novel mechanism of inhibition of elastase by beta-lactams is defined by two inhibitor crystal complexes. |
| Related PDB | |
| Related UniProtKB | |
| [44] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 10739939 |
| Journal | Acta Crystallogr D Biol Crystallogr |
| Year | 2000 |
| Volume | 56 |
| Pages | 520-3 |
| Authors | Wurtele M, Hahn M, Hilpert K, Hohne W |
| Title | Atomic resolution structure of native porcine pancreatic elastase at 1.1 A. |
| Related PDB | 1qnj |
| Related UniProtKB | |
| [45] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 11023818 |
| Journal | Biochem J |
| Year | 2000 |
| Volume | 351 Pt 2 |
| Pages | 335-40 |
| Authors | Wright PA, Wilmouth RC, Clifton IJ, Schofield CJ |
| Title | 'pH-jump' crystallographic analyses of gamma-lactam-porcine pancreatic elastase complexes. |
| Related PDB | 1e34 1e35 1e36 1e37 1e38 |
| Related UniProtKB | |
| [46] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 10738204 |
| Journal | Biopolymers |
| Year | 2000 |
| Volume | 53 |
| Pages | 434-45 |
| Authors | Nakanishi I, Kinoshita T, Sato A, Tada T |
| Title |
Structure of porcine pancreatic elastase complexed with FR901277, |
| Related PDB | 1qr3 |
| Related UniProtKB | |
| [47] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 11310599 |
| Journal | Bioorg Med Chem |
| Year | 2001 |
| Volume | 9 |
| Pages | 647-51 |
| Authors | Odagaki Y, Ohmoto K, Matsuoka S, Hamanaka N, Nakai H, Toda M, Katsuya Y |
| Title | The crystal structure of the complex of non-peptidic inhibitor of human neutrophil elastase ONO-6818 and porcine pancreatic elastase. |
| Related PDB | 1fzz |
| Related UniProtKB | |
| [48] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 11294386 |
| Journal | Bioorg Med Chem Lett |
| Year | 2001 |
| Volume | 11 |
| Pages | 895-8 |
| Authors | Macdonald SJ, Dowle MD, Harrison LA, Shah P, Johnson MR, Inglis GG, Clarke GD, Smith RA, Humphreys D, Molloy CR, Amour A, Dixon M, Murkitt G, Godward RE, Padfield T, Skarzynski T, Singh OM, Kumar KA, Fleetwood G, Hodgson ST, Hardy GW, Finch H |
| Title |
The discovery of a potent, |
| Related PDB | 1hv7 |
| Related UniProtKB | |
| [49] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 11358514 |
| Journal | Eur J Biochem |
| Year | 2001 |
| Volume | 268 |
| Pages | 2969-74 |
| Authors | Wright PA, Wilmouth RC, Clifton IJ, Schofield CJ |
| Title | Kinetic and crystallographic analysis of complexes formed between elastase and peptides from beta-casein. |
| Related PDB | 1h9l |
| Related UniProtKB | |
| [50] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 11473259 |
| Journal | Nat Struct Biol |
| Year | 2001 |
| Volume | 8 |
| Pages | 689-94 |
| Authors | Wilmouth RC, Edman K, Neutze R, Wright PA, Clifton IJ, Schneider TR, Schofield CJ, Hajdu J |
| Title | X-ray snapshots of serine protease catalysis reveal a tetrahedral intermediate. |
| Related PDB | 1hax 1hay 1haz 1hb0 |
| Related UniProtKB | |
| [51] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11730873 |
| Journal | Phytochemistry |
| Year | 2001 |
| Volume | 58 |
| Pages | 1087-95 |
| Authors | Matern U, Oberer L, Falchetto RA, Erhard M, Konig WA, Herdman M, Weckesser J |
| Title |
Scyptolin A and B, |
| Related PDB | |
| Related UniProtKB | |
| [52] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 12037300 |
| Journal | Acta Crystallogr D Biol Crystallogr |
| Year | 2002 |
| Volume | 58 |
| Pages | 976-91 |
| Authors | Evans G, Bricogne G |
| Title | Triiodide derivatization and combinatorial counter-ion replacement: two methods for enhancing phasing signal using laboratory Cu Kalpha X-ray equipment. |
| Related PDB | 1gwa |
| Related UniProtKB | |
| [53] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11914493 |
| Journal | Acta Crystallogr D Biol Crystallogr |
| Year | 2002 |
| Volume | 58 |
| Pages | 672-4 |
| Authors | Hilpert K, Schneider-Mergener J, Ay J |
| Title | Crystallization and preliminary X-ray analysis of the complex of porcine pancreatic elastase and a hybrid squash inhibitor. |
| Related PDB | |
| Related UniProtKB | |
| [54] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 12198297 |
| Journal | Acta Crystallogr D Biol Crystallogr |
| Year | 2002 |
| Volume | 58 |
| Pages | 1413-20 |
| Authors | Panjikar S, Tucker PA |
| Title | Xenon derivatization of halide-soaked protein crystals. |
| Related PDB | 1l0z 1l1g 1lka 1lkb |
| Related UniProtKB | |
| [55] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12109112 |
| Journal | Chem Commun (Camb) |
| Year | 2002 |
| Volume | -12 |
| Pages | 1274-5 |
| Authors | Migaud ME, Wilmouth RC, Mills GI, Wayne GJ, Risley C, Chambers C, Macdonald SJ, Schofield CJ |
| Title | 5,5-Fused thiophene gamma-lactams as templates for serine protease inhibition. |
| Related PDB | |
| Related UniProtKB | |
| [56] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 11896054 |
| Journal | J Biol Chem |
| Year | 2002 |
| Volume | 277 |
| Pages | 21962-70 |
| Authors | Katona G, Wilmouth RC, Wright PA, Berglund GI, Hajdu J, Neutze R, Schofield CJ |
| Title | X-ray structure of a serine protease acyl-enzyme complex at 0.95-A resolution. |
| Related PDB | 1gvk |
| Related UniProtKB | |
| [57] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 12554935 |
| Journal | Acta Crystallogr D Biol Crystallogr |
| Year | 2003 |
| Volume | 59 |
| Pages | 247-54 |
| Authors | Ay J, Hilpert K, Krauss N, Schneider-Mergener J, Hohne W |
| Title | Structure of a hybrid squash inhibitor in complex with porcine pancreatic elastase at 1.8 A resolution. |
| Related PDB | 1mcv |
| Related UniProtKB | |
| [58] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 12467609 |
| Journal | Bioorg Med Chem Lett |
| Year | 2003 |
| Volume | 13 |
| Pages | 21-4 |
| Authors | Kinoshita T, Nakanishi I, Sato A, Tada T |
| Title |
True interaction mode of porcine pancreatic elastase with FR136706, |
| Related PDB | 1mmj |
| Related UniProtKB | |
| [59] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 14583266 |
| Journal | Chem Biol |
| Year | 2003 |
| Volume | 10 |
| Pages | 997-1001 |
| Authors | Matern U, Schleberger C, Jelakovic S, Weckesser J, Schulz GE |
| Title | Binding structure of elastase inhibitor scyptolin A. |
| Related PDB | 1okx |
| Related UniProtKB | |
| [60] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | |
| Journal | Acta Crystallogr D Biol Crystallogr |
| Year | 2004 |
| Volume | 60 |
| Pages | 28-38 |
| Authors | Mueller-Dieckmann C, Polentarutti M, Djinovic-Carugo K, Panjikar S, Tucker PA, Weiss MS |
| Title |
On the Routine Use of Soft X-Rays in Macromolecular Crystallography. |
| Related PDB | 1uo6 |
| Related UniProtKB | |
| [61] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 14593107 |
| Journal | J Biol Chem |
| Year | 2004 |
| Volume | 279 |
| Pages | 9264-9 |
| Authors | Dobo J, Gettins PG |
| Title |
alpha1-Proteinase inhibitor forms initial non-covalent and final covalent complexes with elastase analogously to other serpin-proteinase pairs, |
| Related PDB | |
| Related UniProtKB | |
| Comments |
|---|
|
E.C. This enzyme belongs to the peptidase family-S1. Although this enzyme binds a calcium ion, As this enzyme has got a catalytic triad composed of Ser/His/Asp, |
| Created | Updated |
|---|---|
| 2004-03-25 | 2011-02-22 |