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References
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[1]
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Resource
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Comments
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ACTIVE SITE PEPTIDES OF CHYMOSIN B.
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Medline ID
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75060332
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PubMed ID
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4612029
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Journal
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J Biochem (Tokyo)
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Year
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1974
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Volume
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76
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Pages
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467-74
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Authors
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Chang WJ, Takahashi K
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Title
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The structure and function of acid proteases. III. Isolation and characterization of the active-site peptides from bovine rennin.
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Related PDB
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Related UniProtKB
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P00794
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[2]
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Resource
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Comments
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Medline ID
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PubMed ID
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2501781
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Journal
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Protein Eng
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Year
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1989
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Volume
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2
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Pages
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563-9
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Authors
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Suzuki J, Sasaki K, Sasao Y, Hamu A, Kawasaki H, Nishiyama M, Horinouchi S, Beppu T
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Title
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Alteration of catalytic properties of chymosin by site-directed mutagenesis.
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Related PDB
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Related UniProtKB
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[3]
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Resource
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Comments
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X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF MUTANT.
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Medline ID
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91104895
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PubMed ID
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2271625
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Journal
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Biochemistry
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Year
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1990
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Volume
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29
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Pages
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9863-71
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Authors
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Strop P, Sedlacek J, Stys J, Kaderabkova Z, Blaha I, Pavlickova L, Pohl J, Fabry M, Kostka V, Newman M, et al
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Title
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Engineering enzyme subsite specificity: preparation, kinetic characterization, and X-ray analysis at 2.0-A resolution of Val111Phe site-mutated calf chymosin.
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Related PDB
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3cms
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Related UniProtKB
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P00794
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[4]
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Resource
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Comments
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Medline ID
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PubMed ID
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2217134
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Journal
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Protein Eng
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Year
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1990
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Volume
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3
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Pages
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605-9
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Authors
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Mantafounis D, Pitts J
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Title
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Protein engineering of chymosin; modification of the optimum pH of enzyme catalysis.
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Related PDB
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Related UniProtKB
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[5]
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Resource
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Comments
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X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
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Medline ID
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91017501
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PubMed ID
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2217166
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Journal
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Proteins
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Year
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1990
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Volume
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8
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Pages
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82-101
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Authors
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Gilliland GL, Winborne EL, Nachman J, Wlodawer A
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Title
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The three-dimensional structure of recombinant bovine chymosin at 2.3 A resolution.
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Related PDB
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1cms
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Related UniProtKB
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P00794
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[6]
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Resource
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Comments
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Medline ID
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PubMed ID
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1812745
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Journal
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Adv Exp Med Biol
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Year
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1991
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Volume
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306
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Pages
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47-61
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Authors
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Cooper JB, Newman MP
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Title
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X-ray structural studies of mammalian aspartic proteinases.
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Related PDB
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Related UniProtKB
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[7]
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Resource
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Comments
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Medline ID
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PubMed ID
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1812710
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Journal
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Adv Exp Med Biol
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Year
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1991
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Volume
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306
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Pages
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23-37
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Authors
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Gilliland GL, Oliva MT, Dill J
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Title
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Functional implications of the three-dimensional structure of bovine chymosin.
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Related PDB
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Related UniProtKB
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[8]
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Resource
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Comments
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Medline ID
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PubMed ID
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1820027
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Journal
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Biomed Biochim Acta
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Year
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1991
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Volume
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50
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Pages
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S102-5
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Authors
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Abdel Malak CA, Lavrenova GI
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Title
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Chymosin-catalyzed peptide synthesis.
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Related PDB
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Related UniProtKB
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[9]
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Resource
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Comments
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X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
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Medline ID
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92046065
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PubMed ID
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1942052
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Journal
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J Mol Biol
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Year
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1991
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Volume
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221
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Pages
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1295-309
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Authors
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Newman M, Safro M, Frazao C, Khan G, Zdanov A, Tickle IJ, Blundell TL, Andreeva N
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Title
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X-ray analyses of aspartic proteinases. IV. Structure and refinement at 2.2 A resolution of bovine chymosin.
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Related PDB
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4cms
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Related UniProtKB
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P00794
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[10]
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Resource
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Comments
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Medline ID
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PubMed ID
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1575726
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Journal
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Biochem Biophys Res Commun
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Year
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1992
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Volume
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184
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Pages
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1074-81
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Authors
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Andreeva N, Dill J, Gilliland GL
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Title
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Can enzymes adopt a self-inhibited form? Results of x-ray crystallographic studies of chymosin.
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Related PDB
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Related UniProtKB
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[11]
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Resource
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Comments
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MUTAGENESIS OF CYS-308 AND CYS-341.
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Medline ID
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92412108
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PubMed ID
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1530626
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Journal
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Biochem Biophys Res Commun
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Year
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1992
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Volume
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187
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Pages
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692-6
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Authors
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Huang K, Zhang Z, Liu N, Zhang Y, Zhang G, Yang K
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Title
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Functional implication of disulfide bond, Cys250 -Cys283, in bovine chymosin.
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Related PDB
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Related UniProtKB
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P00794
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[12]
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Resource
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Comments
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Medline ID
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PubMed ID
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1603805
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Journal
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Proteins
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Year
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1992
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Volume
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12
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Pages
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158-70
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Authors
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Sali A, Veerapandian B, Cooper JB, Moss DS, Hofmann T, Blundell TL
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Title
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Domain flexibility in aspartic proteinases.
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Related PDB
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Related UniProtKB
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[13]
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Resource
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Comments
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Medline ID
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PubMed ID
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8540386
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Journal
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Adv Exp Med Biol
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Year
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1995
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Volume
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362
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Pages
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95-9
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Authors
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Dhanaraj RR, Pitts JE, Nugent P, Orprayoon P, Cooper JB, Blundell TL, Uusitalo J, Penttila M
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Title
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Protein engineering of surface loops: preliminary X-ray analysis of the CHY155-165RHI mutant.
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Related PDB
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Related UniProtKB
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[14]
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Resource
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Comments
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|
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Medline ID
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PubMed ID
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7593830
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Journal
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J Dairy Res
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Year
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1995
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Volume
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62
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Pages
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451-67
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Authors
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Plowman JE, Creamer LK
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Title
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Restrained molecular dynamics study of the interaction between bovine kappa-casein peptide 98-111 and bovine chymosin and porcine pepsin.
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Related PDB
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Related UniProtKB
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[15]
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Resource
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Comments
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Medline ID
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PubMed ID
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8566230
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Journal
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FEBS Lett
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Year
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1996
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Volume
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379
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Pages
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60-2
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Authors
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Gustchina E, Rumsh L, Ginodman L, Majer P, Andreeva N
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Title
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Post X-ray crystallographic studies of chymosin: the existence of two structural forms and the regulation of activity by the interaction with the histidine-proline cluster of kappa-casein.
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Related PDB
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Related UniProtKB
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[16]
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Resource
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Comments
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Medline ID
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PubMed ID
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8931128
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Journal
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Protein Eng
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Year
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1996
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Volume
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9
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Pages
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885-93
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Authors
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Nugent PG, Albert A, Orprayoon P, Wilsher J, Pitts JE, Blundell TL, Dhanaraj V
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Title
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Protein engineering loops in aspartic proteinases: site-directed mutagenesis, biochemical characterization and X-ray analysis of chymosin with a replaced loop from rhizopuspepsin.
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Related PDB
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Related UniProtKB
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[17]
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Resource
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Comments
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Medline ID
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PubMed ID
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9434118
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Journal
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Biochim Biophys Acta
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Year
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1997
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Volume
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1343
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Pages
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278-86
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Authors
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Zhang Y, Li H, Wu H, Don Y, Liu N, Yang K
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Title
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Functional implications of disulfide bond, Cys45-Cys50, in recombinant prochymosin.
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Related PDB
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Related UniProtKB
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[18]
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Resource
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Comments
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Medline ID
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PubMed ID
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9464563
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Journal
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Protein Eng
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Year
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1997
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Volume
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10
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Pages
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991-7
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Authors
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Williams MG, Wilsher J, Nugent P, Mills A, Dhanaraj V, Fabry M, Sedlacek J, Uusitalo JM, Penttila ME, Pitts JE, Blundell TL
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Title
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Mutagenesis, biochemical characterization and X-ray structural analysis of point mutants of bovine chymosin.
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Related PDB
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Related UniProtKB
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[19]
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Resource
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Comments
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Medline ID
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PubMed ID
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9561215
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Journal
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Adv Exp Med Biol
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Year
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1998
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Volume
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436
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Pages
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169-77
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Authors
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Albert A, Blundell TL, Dhanaraj V, Donate LE, Groves M, Guruprasad K, Nugent PG, Orprayoon P, Pitts JE, Rufino S, Srinivasan N, Williams M, Wilsher J
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Title
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Protein engineering aspartic proteinases. Site-directed mutagenesis, biochemical characterisation, and X-ray analysis of chymosins with substituted single amino acid substitutions and loop replacements.
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Related PDB
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Related UniProtKB
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[20]
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Resource
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Comments
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Medline ID
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PubMed ID
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9561216
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Journal
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Adv Exp Med Biol
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Year
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1998
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Volume
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436
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Pages
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179-84
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Authors
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Gustchina EA, Majer P, Rumsh LD, Ginodman LM, Andreeva NS
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Title
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Post X-ray crystallographic studies of chymosin specificity. The role of histidine-proline cluster of kappa-casein in catalytic reactions.
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Related PDB
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Related UniProtKB
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[21]
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Resource
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Comments
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Medline ID
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PubMed ID
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9794784
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Journal
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Biochem J
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Year
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1998
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Volume
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335
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Pages
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481-90
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Authors
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Richter C, Tanaka T, Yada RY
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Title
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Mechanism of activation of the gastric aspartic proteinases: pepsinogen, progastricsin and prochymosin.
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Related PDB
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Related UniProtKB
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[22]
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Resource
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Comments
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X-ray crystallography
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Medline ID
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PubMed ID
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9862200
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Journal
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Protein Eng
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Year
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1998
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Volume
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11
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Pages
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833-40
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Authors
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Groves MR, Dhanaraj V, Badasso M, Nugent P, Pitts JE, Hoover DJ, Blundell TL
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Title
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A 2.3 A resolution structure of chymosin complexed with a reduced bond inhibitor shows that the active site beta-hairpin flap is rearranged when compared with the native crystal structure.
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Related PDB
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1czi
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Related UniProtKB
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[23]
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Resource
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Comments
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Medline ID
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PubMed ID
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11015192
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Journal
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Biochemistry
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Year
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2000
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Volume
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39
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Pages
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12140-8
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Authors
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Chen H, Zhang G, Zhang Y, Dong Y, Yang K
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Title
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Functional implications of disulfide bond, Cys206-Cys210, in recombinant prochymosin (chymosin).
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Related PDB
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Related UniProtKB
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[24]
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Resource
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Comments
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Medline ID
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PubMed ID
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11298755
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Journal
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Eur J Biochem
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Year
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2001
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Volume
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268
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Pages
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2362-8
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Authors
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Francky A, Francky BM, Strukelj B, Gruden K, Ritonja A, Krizaj I, Kregar I, Pain RH, Pungercar J
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Title
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A basic residue at position 36p of the propeptide is not essential for the correct folding and subsequent autocatalytic activation of prochymosin.
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Related PDB
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Related UniProtKB
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[25]
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Resource
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Comments
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Medline ID
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PubMed ID
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15568804
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Journal
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Biochemistry
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Year
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2004
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Volume
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43
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Pages
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15122-30
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Authors
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Kageyama T
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Title
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Role of S'1 loop residues in the substrate specificities of pepsin A and chymosin.
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Related PDB
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Related UniProtKB
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