RLCP 1.12.38700.511 :EzCatDB EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms


R 1.-.-.- : Hydrolysis (bond cleavage by water) (Reaction)

L 1.12.-.- : Carboxylic Ester (One of Carbonyl Ester bonds) (Ligand group involved)

C 1.12.38700.- : Phospholipase-A1-like mechanism (Nucleophile/Acid-Base/Modulator/Stabilizer); Inorganic cofactor-assisted activation of target bond; Inorganic cofactor-assisted base activation of nucleophile; Nucleophilic attack on target bond forming intermediate; Inorganic cofactor-assisted stabilization of intermediate; Nucleophilic attack by water on intermediate (Catalytic mechanism)

P 1.12.38700.511 : Ser/His/Asn + mainchain amide + calcium ion bound to mainchain carbonyl group and Ser (Residues/cofactors in Protein)

1st Nucleophile : a catalytic residue
Catalytic groups : cofactor + groups in residue/substrate
General Base : a catalytic residue
General Acid : a catalytic residue

Related Enzymes

There is one entry in this class.
  • S00127 : 3.1.1.4, 3.1.1.32; Phospholipase A1 (Catalytic domain; 2.40.230.10)
    • Copyright: Nozomi Nagano, JST & CBRC-AIST
    Funded by PRESTO/Japan Science and Technology Agency (JST) (December 2001 - November 2004)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
    Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (September 2005 - September 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (October 2007 - September 2010)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2012 - March 2013)
    Supported by the commission for the Development of Artificial Gene Synthesis Technology for Creating Innovative Biomaterial from the Ministry of Economy, Trade and Industry (METI) (October 2012 - March 2016)
    Funded by the project commissioned by the New Energy and Industrial Technology Development Organization (NEDO) (April 2016 -)