RLCP 3.103.126600.1165 :EzCatDB EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms


R 3.-.-.- : Transfer (bond cleavage and new bond formation) (Reaction)

L 3.103.-.- : Phosphate group from Phosphate oxygen to Hydroxyl oxygen (Ligand group involved)

C 3.103.126600.- : Phosphorylase-kinase-like mechanism (Base-Acid/Stabilizer); Inorganic-cofactor-assisted SN1-like transition state between acceptor/transferred/leaving groups; Base deprotonation of acceptor group; Covalent bond formed between acceptor and transferred group; Acid protonation to transferred group; Inorganic-cofactor interacting with transferred/leaving groups (Catalytic mechanism)

P 3.103.126600.1165 : Asp + Lys cluster + mainchain amide + two magnesium ions bound to Asn/Asp (Residues/cofactors in Protein)

1st Nucleophile : an acceptor group in substrate
Catalytic groups : cofactor + groups in residue/substrate
General Base : a catalytic residue
General Acid : a catalytic residue

Related Enzymes

There are 3 entries in this class.
  • M00196 : 2.7.11.22; Cyclin-dependent kinase 5 (Catalytic domains; 1.10.510.10, 3.30.200.20)
  • M00197 : 2.7.11.1; Casein kinase II subunit alpha (Catalytic domains; 1.10.510.10, 3.30.200.20)
  • M00198 : 2.7.11.19; Phosphorylase b kinase regulatory subunit alpha (Catalytic domains; 1.10.510.10, 3.30.200.20)
    • Copyright: Nozomi Nagano, JST & CBRC-AIST
    Funded by PRESTO/Japan Science and Technology Agency (JST) (December 2001 - November 2004)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
    Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (September 2005 - September 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (October 2007 - September 2010)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2012 - March 2013)
    Supported by the commission for the Development of Artificial Gene Synthesis Technology for Creating Innovative Biomaterial from the Ministry of Economy, Trade and Industry (METI) (October 2012 - March 2016)
    Funded by the project commissioned by the New Energy and Industrial Technology Development Organization (NEDO) (April 2016 -)