RLCP 1.15.8230.361 :EzCatDB EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms


R 1.-.-.- : Hydrolysis (bond cleavage by water) (Reaction)

L 1.15.-.- : Phosphoric Ester (Ligand group involved)

C 1.15.8230.- : DNA topoisomerase-II ATP hydrolysis mechanism (Base/Stabilizer); Water activation by base; Nucleophilic attack by water; Cofactor-assisted stabilization of transition-state; rather SN2 reaction (Catalytic mechanism)

P 1.15.8230.361 : An acidic residue + Lys + mainchain amide + magnesium ion bound to Asn (Residues/cofactors in Protein)

1st Nucleophile : water
Catalytic groups : cofactor + groups in residue/substrate
General Base : a catalytic residue
General Acid : non-existent

Related Enzymes

There are 2 entries in this class.
  • M00213 : (reaction 1) 5.99.1.3; DNA gyrase subunit B (Catalytic domains; 3.30.230.10, 3.30.565.10)
  • M00048 : (reaction 4) 5.99.1.3; DNA topoisomerase 2 (Catalytic domains; 3.30.230.10, 3.30.565.10, 3.40.50.670, 3.90.199.10)
    • Copyright: Nozomi Nagano, JST & CBRC-AIST
    Funded by PRESTO/Japan Science and Technology Agency (JST) (December 2001 - November 2004)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
    Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (September 2005 - September 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (October 2007 - September 2010)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2012 - March 2013)
    Supported by the commission for the Development of Artificial Gene Synthesis Technology for Creating Innovative Biomaterial from the Ministry of Economy, Trade and Industry (METI) (October 2012 - March 2016)
    Funded by the project commissioned by the New Energy and Industrial Technology Development Organization (NEDO) (April 2016 -)