DB code: M00166
| RLCP classification | 1.13.200.966 : Hydrolysis | |
|---|---|---|
| 3.103.90021.1120 : Transfer | ||
| CATH domain | 1.10.150.90 : DNA polymerase; domain 1 | |
| 1.10.375.- : Human Immunodeficiency Virus Type 1 Capsid Protein | ||
| 1.10.1200.- : Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein; Chain A | ||
| 4.10.60.- : HIV-1 Nucleocapsid Protein | ||
| -.-.-.- : | ||
| 2.40.70.10 : Cathepsin D, subunit A; domain 1 | Catalytic domain | |
| -.-.-.- : | ||
| 3.10.10.10 : HIV Type 1 Reverse Transcriptase; Chain A, domain 1 | ||
| 3.30.70.270 : Alpha-Beta Plaits | Catalytic domain | |
| 3.30.70.270 : Alpha-Beta Plaits | ||
| 3.30.70.270 : Alpha-Beta Plaits | ||
| 3.30.420.10 : Nucleotidyltransferase; domain 5 | Catalytic domain | |
| 1.10.10.200 : Arc Repressor Mutant, subunit A | ||
| 3.30.420.10 : Nucleotidyltransferase; domain 5 | ||
| 2.30.30.- : SH3 type barrels. | ||
| -.-.-.- : | ||
| E.C. | 3.4.23.47 2.7.7.49 2.7.7.7 3.1.26.4 | |
| CSA | ||
| M-CSA | ||
| MACiE | ||
| CATH domain | Related DB codes (homologues) |
|---|---|
| 1.10.10.200 : Arc Repressor Mutant, subunit A | M00206 |
| 2.40.70.10 : Cathepsin D, subunit A; domain 1 | D00471 D00436 D00438 D00439 D00440 D00441 D00442 D00443 D00437 D00444 D00423 D00445 D00484 M00206 D00231 D00529 |
| 3.10.10.10 : HIV Type 1 Reverse Transcriptase; Chain A, domain 1 | M00206 M00135 M00146 |
| 3.30.420.10 : Nucleotidyltransferase; domain 5 | M00206 T00252 M00019 M00020 M00055 M00135 M00146 M00173 M00175 M00186 |
| 3.30.70.270 : Alpha-Beta Plaits | M00206 M00019 M00135 M00146 M00209 |
| Uniprot Enzyme Name | UniprotKB | Protein name | Synonyms | Contains | Pfam |
|---|---|---|---|---|
| P04584 |
Gag-Pol polyprotein
|
Pr160Gag-Pol
|
Matrix protein p17
(MA) Capsid protein p24 (CA) Spacer peptide p2 Nucleocapsid protein p7 (NC) Transframe peptide (TF) p6-pol (p6*) Protease EC 3.4.23.47 PR Retropepsin Reverse transcriptase/ribonuclease H EC 2.7.7.49 EC 2.7.7.7 EC 3.1.26.13 Exoribonuclease H EC 3.1.13.2 p66 RT p51 RT p15 Integrase (IN) |
PF00540
(Gag_p17)
PF00607 (Gag_p24) PF00552 (IN_DBD_C) PF02022 (Integrase_Zn) PF00075 (RNase_H) PF00665 (rve) PF00077 (RVP) PF00078 (RVT_1) PF06815 (RVT_connect) PF06817 (RVT_thumb) PF00098 (zf-CCHC) [Graphical View] |
| KEGG enzyme name |
|---|
|
HIV-2 retropepsin
(EC 3.4.23.47 ) RNA-directed DNA polymerase (EC 2.7.7.49 ) DNA nucleotidyltransferase (RNA-directed) (EC 2.7.7.49 ) reverse transcriptase (EC 2.7.7.49 ) revertase (EC 2.7.7.49 ) RNA-dependent deoxyribonucleate nucleotidyltransferase (EC 2.7.7.49 ) RNA revertase (EC 2.7.7.49 ) RNA-dependent DNA polymerase (EC 2.7.7.49 ) RNA-instructed DNA polymerase (EC 2.7.7.49 ) RT (EC 2.7.7.49 ) DNA-directed DNA polymerase (EC 2.7.7.7 ) DNA polymerase I (EC 2.7.7.7 ) DNA polymerase II (EC 2.7.7.7 ) DNA polymerase III (EC 2.7.7.7 ) DNA polymerase alpha (EC 2.7.7.7 ) DNA polymerase beta (EC 2.7.7.7 ) DNA polymerase gamma (EC 2.7.7.7 ) DNA nucleotidyltransferase (DNA-directed) (EC 2.7.7.7 ) DNA nucleotidyltransferase (DNA-directed) (EC 2.7.7.7 ) deoxyribonucleate nucleotidyltransferase (EC 2.7.7.7 ) deoxynucleate polymerase (EC 2.7.7.7 ) deoxyribonucleic acid duplicase (EC 2.7.7.7 ) deoxyribonucleic acid polymerase (EC 2.7.7.7 ) deoxyribonucleic duplicase (EC 2.7.7.7 ) deoxyribonucleic polymerase (EC 2.7.7.7 ) deoxyribonucleic polymerase I (EC 2.7.7.7 ) DNA duplicase (EC 2.7.7.7 ) DNA nucleotidyltransferase (EC 2.7.7.7 ) DNA polymerase (EC 2.7.7.7 ) DNA replicase (EC 2.7.7.7 ) DNA-dependent DNA polymerase (EC 2.7.7.7 ) duplicase (EC 2.7.7.7 ) Klenow fragment (EC 2.7.7.7 ) sequenase (EC 2.7.7.7 ) Taq DNA polymerase (EC 2.7.7.7 ) Taq Pol I (EC 2.7.7.7 ) Tca DNA polymerase (EC 2.7.7.7 ) calf thymus ribonuclease H (EC 3.1.26.4 ) endoribonuclease H (calf thymus) (EC 3.1.26.4 ) RNase H (EC 3.1.26.4 ) RNA*DNA hybrid ribonucleotidohydrolase (EC 3.1.26.4 ) hybrid ribonuclease (EC 3.1.26.4 ) hybridase (EC 3.1.26.4 ) hybridase (ribonuclease H) (EC 3.1.26.4 ) ribonuclease H (EC 3.1.26.4 ) hybrid nuclease (EC 3.1.26.4 ) |
| UniprotKB: Accession Number | Entry name | Activity | Subunit | Subcellular location | Cofactor |
|---|---|---|---|---|---|
| P04584 | POL_HV2RO | Endonucleolytic cleavage to 5''- phosphomonoester. Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Endopeptidase for which the P1 residue is preferably hydrophobic. | Matrix protein p17 is a trimer. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues. The reverse transcriptase is a heterodimer of p66 RT and p51 RT (RT p66/p51). Heterodimerization of RT is essential for DNA polymerase activity. Despite the sequence identities, p66 RT and p51 RT have distinct folding. The integrase is a homodimer and possibly a homotetramer (By similarity). | Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential). Nucleus (Potential). Cytoplasm (Potential). Note=Nuclear at initial phase, cytoplasmic at assembly (Potential). Matrix protein p17: Virion (Potential). Nucleus (By similarity). Cytoplasm (By similarity). Cell membrane, Lipid-anchor (Potential). Note=Following virus entry, the nuclear localization signal (NLS) of the matrix protein participates with Vpr to the nuclear localization of the viral genome. During virus production, the nuclear export activity of the matrix protein counteracts the NLS to maintain the Gag and Gag-Pol polyproteins in the cytoplasm, thereby directing unspliced RNA to the plasma membrane (By similarity). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). | Binds 2 magnesium ions for reverse transcriptase polymerase activity (By similarity). Binds 2 magnesium ions for ribonuclease H (RNase H) activity. Substrate-binding is a precondition for magnesium binding (By similarity). Magnesium ions for integrase activity. Binds at least 1, maybe 2 magnesium ions (By similarity). |
| KEGG Pathways | Map code | Pathways | E.C. |
|---|---|---|
| MAP00230 | Purine metabolism | 2.7.7.7 |
| MAP00240 | Pyrimidine metabolism | 2.7.7.7 |
| Compound table | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cofactors | Substrates | Products | Intermediates | ||||||||||||||||
| KEGG-id | C00305 | C00038 | C00017 | C00012 | C00677 | C00039 | C00046 | C00001 | C00017 | C00012 | C00013 | C00039 | C00960 | I00136 | |||||
| E.C. |
2.7.7.49
2.7.7.7 3.1.26.4 |
3.4.23.47
|
3.4.23.47
|
2.7.7.49
2.7.7.7 |
2.7.7.49
2.7.7.7 |
3.1.26.4
|
3.1.26.4
3.4.23.47 |
3.4.23.47
|
3.4.23.47
|
2.7.7.49
2.7.7.7 |
2.7.7.49
2.7.7.7 |
3.1.26.4
|
3.4.23.47
|
||||||
| Compound | Magnesium | Zinc | Protein | Peptide | Deoxynucleoside triphosphate | DNA(n) | RNA | H2O | Protein | Peptide | Pyrophosphate | DNA(n+1) | RNA 5'-phosphate | Amino-diol-tetrahedral intermediate | |||||
| Type | divalent metal (Ca2+, Mg2+) | heavy metal | peptide/protein | peptide/protein | nucleotide | nucleic acids | nucleic acids | H2O | peptide/protein | peptide/protein | phosphate group/phosphate ion | nucleic acids | nucleic acids,phosphate group/phosphate ion | ||||||
| ChEBI |
18420 18420 |
29105 29105 |
15377 15377 |
29888 29888 |
|||||||||||||||
| PubChem |
888 888 |
32051 32051 |
22247451 962 22247451 962 |
1023 21961011 1023 21961011 |
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| 1hiiA |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:C20 | |
| 1hshA |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:MK1 | |
| 1hshC |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:MK1 | |
| 1hsiA |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1idaA |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:0PO | |
| 1idbA |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:0DO | |
| 1ivpA |
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Unbound | Unbound | Unbound | Analogue:1ZK | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ivqA |
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Unbound | Unbound | Unbound | Analogue:0PX | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1jldA |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:0PP | |
| 2hpeA |
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Unbound | Unbound | Unbound | Bound:UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2hpfA |
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Unbound | Unbound | Unbound | Bound:UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2mipA |
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Unbound | Unbound | Unbound | Analogue:PHE-VAL-PHE-LEU-GLU-ILE-NH2 (chain E,G) | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2mipC |
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Unbound | Unbound | Unbound | Analogue:PHE-VAL-PHE-LEU-GLU-ILE-NH2 (chain F,H) | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3upjA |
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Unbound | Unbound | Unbound | Analogue:U03 | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 4upjA |
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Unbound | Unbound | Unbound | Analogue:U04 | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 5upjA |
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Unbound | Unbound | Unbound | Analogue:UIN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 6upjA |
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Unbound | Unbound | Unbound | Analogue:NIU | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1hiiB |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1hshB |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1hshD |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1hsiB |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1idaB |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1idbB |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ivpB |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ivqB |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1jldB |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2hpeB |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2hpfB |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2mipB |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2mipD |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3upjB |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 4upjB |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 5upjB |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 6upjB |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1mu2A01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1mu2B01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1mu2A02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1mu2B02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1mu2A03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1mu2B03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1mu2A04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1mu2B04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1mu2A05 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kA01 |
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Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kB01 |
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Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kE01 |
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Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kF01 |
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Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kI01 |
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Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kJ01 |
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Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kM01 |
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Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kN01 |
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Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kQ01 |
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Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kR01 |
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Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kU01 |
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Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kV01 |
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Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kY01 |
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Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kZ01 |
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Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kc01 |
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Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kd01 |
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Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kg01 |
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Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kh01 |
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Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kk01 |
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Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kl01 |
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Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9ko01 |
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Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kp01 |
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Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9ks01 |
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Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kt01 |
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Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1aubA |
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Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1e0eA |
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Unbound | Bound:_ZN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kA02 |
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Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kB02 |
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Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kE02 |
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Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kF02 |
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Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kI02 |
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Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kJ02 |
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Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kM02 |
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Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kN02 |
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Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kQ02 |
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Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kR02 |
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|
|
|
Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kU02 |
|
|
|
|
|
Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kV02 |
|
|
|
|
|
Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kY02 |
|
|
|
|
|
Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kZ02 |
|
|
|
|
|
Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kc02 |
|
|
|
|
|
Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kd02 |
|
|
|
|
|
Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kg02 |
|
|
|
|
|
Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kh02 |
|
|
|
|
|
Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kk02 |
|
|
|
|
|
Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kl02 |
|
|
|
|
|
Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9ko02 |
|
|
|
|
|
Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kp02 |
|
|
|
|
|
Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9ks02 |
|
|
|
|
|
Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3f9kt02 |
|
|
|
|
|
Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| Reference for Active-site residues | ||
|---|---|---|
| resource | references | E.C. |
| PDB;1aub & literature [6], M00135, M00146 | ||
| Active-site residues | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Catalytic residues | Cofactor-binding residues | Modified residues | Main-chain involved in catalysis | Comment | |||||
| 1hiiA |
|
|
|
|
|
ASP 25 | (EC 3.4.23.47) | |||
| 1hshA |
|
|
|
|
|
ASP 25 | (EC 3.4.23.47) | |||
| 1hshC |
|
|
|
|
|
ASP 25 | (EC 3.4.23.47) | |||
| 1hsiA |
|
|
|
|
|
ASP 25 | (EC 3.4.23.47) | |||
| 1idaA |
|
|
|
|
|
ASP 25 | (EC 3.4.23.47) | |||
| 1idbA |
|
|
|
|
|
ASP 25 | (EC 3.4.23.47) | |||
| 1ivpA |
|
|
|
|
|
ASP 25 | (EC 3.4.23.47) mutant K57L | |||
| 1ivqA |
|
|
|
|
|
ASP 25 | (EC 3.4.23.47) mutant K57L | |||
| 1jldA |
|
|
|
|
|
ASP 25 | (EC 3.4.23.47) | |||
| 2hpeA |
|
|
|
|
|
ASP 25 | (EC 3.4.23.47) mutant K57L | |||
| 2hpfA |
|
|
|
|
|
ASP 25 | (EC 3.4.23.47) mutant K57L | |||
| 2mipA |
|
|
|
|
|
ASP 25 | (EC 3.4.23.47) | |||
| 2mipC |
|
|
|
|
|
ASP 25 | (EC 3.4.23.47) | |||
| 3upjA |
|
|
|
|
|
ASP 25 | (EC 3.4.23.47) mutant K57L | |||
| 4upjA |
|
|
|
|
|
ASP 25 | (EC 3.4.23.47) mutant K57L | |||
| 5upjA |
|
|
|
|
|
ASP 25 | (EC 3.4.23.47) mutant K57L | |||
| 6upjA |
|
|
|
|
|
ASP 25 | (EC 3.4.23.47) mutant K57L | |||
| 1hiiB |
|
|
|
|
|
ASP 25 | (EC 3.4.23.47) | |||
| 1hshB |
|
|
|
|
|
ASP 25 | (EC 3.4.23.47) | |||
| 1hshD |
|
|
|
|
|
ASP 25 | (EC 3.4.23.47) | |||
| 1hsiB |
|
|
|
|
|
ASP 25 | (EC 3.4.23.47) | |||
| 1idaB |
|
|
|
|
|
ASP 25 | (EC 3.4.23.47) | |||
| 1idbB |
|
|
|
|
|
ASP 25 | (EC 3.4.23.47) | |||
| 1ivpB |
|
|
|
|
|
ASP 25 | (EC 3.4.23.47) mutant K57L | |||
| 1ivqB |
|
|
|
|
|
ASP 25 | (EC 3.4.23.47) mutant K57L | |||
| 1jldB |
|
|
|
|
|
ASP 25 | (EC 3.4.23.47) | |||
| 2hpeB |
|
|
|
|
|
ASP 25 | (EC 3.4.23.47) mutant K57L | |||
| 2hpfB |
|
|
|
|
|
ASP 25 | (EC 3.4.23.47) mutant K57L | |||
| 2mipB |
|
|
|
|
|
ASP 25 | (EC 3.4.23.47) | |||
| 2mipD |
|
|
|
|
|
ASP 25 | (EC 3.4.23.47) | |||
| 3upjB |
|
|
|
|
|
ASP 25 | (EC 3.4.23.47) mutant K57L | |||
| 4upjB |
|
|
|
|
|
ASP 25 | (EC 3.4.23.47) mutant K57L | |||
| 5upjB |
|
|
|
|
|
ASP 25 | (EC 3.4.23.47) mutant K57L | |||
| 6upjB |
|
|
|
|
|
ASP 25 | (EC 3.4.23.47) mutant K57L | |||
| 1mu2A01 |
|
|
|
|
|
|||||
| 1mu2B01 |
|
|
|
|
|
|||||
| 1mu2A02 |
|
|
|
|
|
ASP 110;ASP 185;ASP 186(Magnesium binding) | ASP 113;ALA 114 | (EC 2.7.7.49 & 2.7.7.7) | ||
| 1mu2B02 |
|
|
|
|
|
|||||
| 1mu2A03 |
|
|
|
|
|
|||||
| 1mu2B03 |
|
|
|
|
|
|||||
| 1mu2A04 |
|
|
|
|
|
|||||
| 1mu2B04 |
|
|
|
|
|
|||||
| 1mu2A05 |
|
|
|
|
|
ASP 442;ASP 497(Magnesium binding) | (EC 3.1.26.4) | |||
| 3f9kA01 |
|
|
|
|
|
HIS 12;HIS 16;CYS 40;CYS 43(Zinc binding) | (integrase) | |||
| 3f9kB01 |
|
|
|
|
|
HIS 12;HIS 16;CYS 40;CYS 43(Zinc binding) | (integrase) | |||
| 3f9kE01 |
|
|
|
|
|
HIS 12;HIS 16;CYS 40;CYS 43(Zinc binding) | (integrase) | |||
| 3f9kF01 |
|
|
|
|
|
HIS 12;HIS 16;CYS 40;CYS 43(Zinc binding) | (integrase) | |||
| 3f9kI01 |
|
|
|
|
|
HIS 12;HIS 16;CYS 40;CYS 43(Zinc binding) | (integrase) | |||
| 3f9kJ01 |
|
|
|
|
|
HIS 12;HIS 16;CYS 40;CYS 43(Zinc binding) | (integrase) | |||
| 3f9kM01 |
|
|
|
|
|
HIS 12;HIS 16;CYS 40;CYS 43(Zinc binding) | (integrase) | |||
| 3f9kN01 |
|
|
|
|
|
HIS 12;HIS 16;CYS 40;CYS 43(Zinc binding) | (integrase) | |||
| 3f9kQ01 |
|
|
|
|
|
HIS 12;HIS 16;CYS 40;CYS 43(Zinc binding) | (integrase) | |||
| 3f9kR01 |
|
|
|
|
|
HIS 12;HIS 16;CYS 40;CYS 43(Zinc binding) | (integrase) | |||
| 3f9kU01 |
|
|
|
|
|
HIS 12;HIS 16;CYS 40;CYS 43(Zinc binding) | (integrase) | |||
| 3f9kV01 |
|
|
|
|
|
HIS 12;HIS 16;CYS 40;CYS 43(Zinc binding) | (integrase) | |||
| 3f9kY01 |
|
|
|
|
|
HIS 12;HIS 16;CYS 40;CYS 43(Zinc binding) | (integrase) | |||
| 3f9kZ01 |
|
|
|
|
|
HIS 12;HIS 16;CYS 40;CYS 43(Zinc binding) | (integrase) | |||
| 3f9kc01 |
|
|
|
|
|
HIS 12;HIS 16;CYS 40;CYS 43(Zinc binding) | (integrase) | |||
| 3f9kd01 |
|
|
|
|
|
HIS 12;HIS 16;CYS 40;CYS 43(Zinc binding) | (integrase) | |||
| 3f9kg01 |
|
|
|
|
|
HIS 12;HIS 16;CYS 40;CYS 43(Zinc binding) | (integrase) | |||
| 3f9kh01 |
|
|
|
|
|
HIS 12;HIS 16;CYS 40;CYS 43(Zinc binding) | (integrase) | |||
| 3f9kk01 |
|
|
|
|
|
HIS 12;HIS 16;CYS 40;CYS 43(Zinc binding) | (integrase) | |||
| 3f9kl01 |
|
|
|
|
|
HIS 12;HIS 16;CYS 40;CYS 43(Zinc binding) | (integrase) | |||
| 3f9ko01 |
|
|
|
|
|
HIS 12;HIS 16;CYS 40;CYS 43(Zinc binding) | (integrase) | |||
| 3f9kp01 |
|
|
|
|
|
HIS 12;HIS 16;CYS 40;CYS 43(Zinc binding) | (integrase) | |||
| 3f9ks01 |
|
|
|
|
|
HIS 12;HIS 16;CYS 40;CYS 43(Zinc binding) | (integrase) | |||
| 3f9kt01 |
|
|
|
|
|
HIS 12;HIS 16;CYS 40;CYS 43(Zinc binding) | (integrase) | |||
| 1aubA |
|
|
|
|
|
HIS 12;HIS 16;CYS 40;CYS 43(Zinc binding) | (integrase) | |||
| 1e0eA |
|
|
|
|
|
HIS 12;HIS 16;CYS 40;CYS 43(Zinc binding) | (integrase) | |||
| 3f9kA02 |
|
|
|
|
|
ASP 64;ASP 116(Magnesium binding) | (integrase) | |||
| 3f9kB02 |
|
|
|
|
|
ASP 64;ASP 116(Magnesium binding) | (integrase) | |||
| 3f9kE02 |
|
|
|
|
|
ASP 64;ASP 116(Magnesium binding) | (integrase) | |||
| 3f9kF02 |
|
|
|
|
|
ASP 64;ASP 116(Magnesium binding) | (integrase) | |||
| 3f9kI02 |
|
|
|
|
|
ASP 64;ASP 116(Magnesium binding) | (integrase) | |||
| 3f9kJ02 |
|
|
|
|
|
ASP 64;ASP 116(Magnesium binding) | (integrase) | |||
| 3f9kM02 |
|
|
|
|
|
ASP 64;ASP 116(Magnesium binding) | (integrase) | |||
| 3f9kN02 |
|
|
|
|
|
ASP 64;ASP 116(Magnesium binding) | (integrase) | |||
| 3f9kQ02 |
|
|
|
|
|
ASP 64;ASP 116(Magnesium binding) | (integrase) | |||
| 3f9kR02 |
|
|
|
|
|
ASP 64;ASP 116(Magnesium binding) | (integrase) | |||
| 3f9kU02 |
|
|
|
|
|
ASP 64;ASP 116(Magnesium binding) | (integrase) | |||
| 3f9kV02 |
|
|
|
|
|
ASP 64;ASP 116(Magnesium binding) | (integrase) | |||
| 3f9kY02 |
|
|
|
|
|
ASP 64;ASP 116(Magnesium binding) | (integrase) | |||
| 3f9kZ02 |
|
|
|
|
|
ASP 64;ASP 116(Magnesium binding) | (integrase) | |||
| 3f9kc02 |
|
|
|
|
|
ASP 64;ASP 116(Magnesium binding) | (integrase) | |||
| 3f9kd02 |
|
|
|
|
|
ASP 64;ASP 116(Magnesium binding) | (integrase) | |||
| 3f9kg02 |
|
|
|
|
|
ASP 64;ASP 116(Magnesium binding) | (integrase) | |||
| 3f9kh02 |
|
|
|
|
|
ASP 64;ASP 116(Magnesium binding) | (integrase) | |||
| 3f9kk02 |
|
|
|
|
|
ASP 64;ASP 116(Magnesium binding) | (integrase) | |||
| 3f9kl02 |
|
|
|
|
|
ASP 64;ASP 116(Magnesium binding) | (integrase) | |||
| 3f9ko02 |
|
|
|
|
|
ASP 64;ASP 116(Magnesium binding) | (integrase) | |||
| 3f9kp02 |
|
|
|
|
|
ASP 64;ASP 116(Magnesium binding) | (integrase) | |||
| 3f9ks02 |
|
|
|
|
|
ASP 64;ASP 116(Magnesium binding) | (integrase) | |||
| 3f9kt02 |
|
|
|
|
|
ASP 64;ASP 116(Magnesium binding) | (integrase) | |||
| References for Catalytic Mechanism | ||
|---|---|---|
| References | Sections | No. of steps in catalysis |
| References | |
|---|---|
| [1] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1812757 |
| Journal | Adv Exp Med Biol |
| Year | 1991 |
| Volume | 306 |
| Pages | 549-53 |
| Authors | Gustchina A, Weber IT, Wlodawer A |
| Title | Molecular modeling of the HIV-2 protease. |
| Related PDB | |
| Related UniProtKB | |
| [2] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 2001747 |
| Journal | FEBS Lett |
| Year | 1991 |
| Volume | 279 |
| Pages | 356-60 |
| Authors | Tozser J, Gustchina A, Weber IT, Blaha I, Wondrak EM, Oroszlan S |
| Title | Studies on the role of the S4 substrate binding site of HIV proteinases. |
| Related PDB | |
| Related UniProtKB | |
| [3] | |
| Resource | |
| Comments | Theoretical model |
| Medline ID | |
| PubMed ID | 1946342 |
| Journal | Proteins |
| Year | 1991 |
| Volume | 10 |
| Pages | 325-39 |
| Authors | Gustchina A, Weber IT |
| Title | Comparative analysis of the sequences and structures of HIV-1 and HIV-2 proteases. |
| Related PDB | 1phv 2phv |
| Related UniProtKB | |
| [4] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8241159 |
| Journal | Biochemistry |
| Year | 1993 |
| Volume | 32 |
| Pages | 13054-60 |
| Authors | Zhao B, Winborne E, Minnich MD, Culp JS, Debouck C, Abdel-Meguid SS |
| Title |
Three-dimensional structure of a simian immunodeficiency virus protease/inhibitor complex. |
| Related PDB | |
| Related UniProtKB | |
| [5] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8087563 |
| Journal | Bioorg Med Chem |
| Year | 1993 |
| Volume | 1 |
| Pages | 415-22 |
| Authors | Sui Z, Salto R, Li J, Craik C, Ortiz de Montellano PR |
| Title | Inhibition of the HIV-1 and HIV-2 proteases by curcumin and curcumin boron complexes. |
| Related PDB | |
| Related UniProtKB | |
| [6] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8514751 |
| Journal | J Biol Chem |
| Year | 1993 |
| Volume | 268 |
| Pages | 13103-9 |
| Authors | Mulichak AM, Hui JO, Tomasselli AG, Heinrikson RL, Curry KA, Tomich CS, Thaisrivongs S, Sawyer TK, Watenpaugh KD |
| Title | The crystallographic structure of the protease from human immunodeficiency virus type 2 with two synthetic peptidic transition state analog inhibitors. |
| Related PDB | |
| Related UniProtKB | |
| [7] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 86-184. |
| Medline ID | 93391360 |
| PubMed ID | 8378311 |
| Journal | Proc Natl Acad Sci U S A |
| Year | 1993 |
| Volume | 90 |
| Pages | 8387-91 |
| Authors | Tong L, Pav S, Pargellis C, Do F, Lamarre D, Anderson PC |
| Title | Crystal structure of human immunodeficiency virus (HIV) type 2 protease in complex with a reduced amide inhibitor and comparison with HIV-1 protease structures. |
| Related PDB | 2mip |
| Related UniProtKB | P04584 |
| [8] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 86-184 IN COMPLEX WITH INHIB. |
| Medline ID | 95014470 |
| PubMed ID | 7929352 |
| Journal | J Biol Chem |
| Year | 1994 |
| Volume | 269 |
| Pages | 26344-8 |
| Authors | Chen Z, Li Y, Chen E, Hall DL, Darke PL, Culberson C, Shafer JA, Kuo LC |
| Title |
Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, |
| Related PDB | 1hsh 1hsi |
| Related UniProtKB | P04584 |
| [9] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8035428 |
| Journal | J Med Chem |
| Year | 1994 |
| Volume | 37 |
| Pages | 2206-15 |
| Authors | Oprea TI, Waller CL, Marshall GR |
| Title |
Three-dimensional quantitative structure-activity relationship of human immunodeficiency virus (I) protease inhibitors. |
| Related PDB | |
| Related UniProtKB | |
| [10] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7526778 |
| Journal | Annu Rev Biochem |
| Year | 1994 |
| Volume | 63 |
| Pages | 133-73 |
| Authors | Katz RA, Skalka AM |
| Title | The retroviral enzymes. |
| Related PDB | |
| Related UniProtKB | |
| [11] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 7783120 |
| Journal | J Med Chem |
| Year | 1995 |
| Volume | 38 |
| Pages | 1884-91 |
| Authors | Romines KR, Watenpaugh KD, Tomich PK, Howe WJ, Morris JK, Lovasz KD, Mulichak AM, Finzel BC, Lynn JC, Horng MM, et al |
| Title | Use of medium-sized cycloalkyl rings to enhance secondary binding: discovery of a new class of human immunodeficiency virus (HIV) protease inhibitors. |
| Related PDB | 5upj 6upj |
| Related UniProtKB | |
| [12] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 7658450 |
| Journal | J Med Chem |
| Year | 1995 |
| Volume | 38 |
| Pages | 3624-37 |
| Authors | Thaisrivongs S, Watenpaugh KD, Howe WJ, Tomich PK, Dolak LA, Chong KT, Tomich CC, Tomasselli AG, Turner SR, Strohbach JW, et al |
| Title | Structure-based design of novel HIV protease inhibitors: carboxamide-containing 4-hydroxycoumarins and 4-hydroxy-2-pyrones as potent nonpeptidic inhibitors. |
| Related PDB | 3upj 4upj |
| Related UniProtKB | |
| [13] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 86-184 IN COMPLEX WITH INHIB. |
| Medline ID | 95338600 |
| PubMed ID | 7613867 |
| Journal | Structure |
| Year | 1995 |
| Volume | 3 |
| Pages | 381-9 |
| Authors | Priestle JP, Fassler A, Rosel J, Tintelnot-Blomley M, Strop P, Grutter MG |
| Title |
Comparative analysis of the X-ray structures of HIV-1 and HIV-2 proteases in complex with CGP 53820, |
| Related PDB | 1hii |
| Related UniProtKB | P04584 |
| [14] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7743130 |
| Journal | Structure |
| Year | 1995 |
| Volume | 3 |
| Pages | 33-40 |
| Authors | Tong L, Pav S, Mui S, Lamarre D, Yoakim C, Beaulieu P, Anderson PC |
| Title | Crystal structures of HIV-2 protease in complex with inhibitors containing the hydroxyethylamine dipeptide isostere. |
| Related PDB | |
| Related UniProtKB | |
| [15] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 86-184 IN COMPLEX WITH INHIB. |
| Medline ID | 97359919 |
| PubMed ID | 9216835 |
| Journal | J Med Chem |
| Year | 1997 |
| Volume | 40 |
| Pages | 2164-76 |
| Authors | Beaulieu PL, Wernic D, Abraham A, Anderson PC, Bogri T, Bousquet Y, Croteau G, Guse I, Lamarre D, Liard F, Paris W, Thibeault D, Pav S, Tong L |
| Title | Potent HIV protease inhibitors containing a novel (hydroxyethyl)amide isostere. |
| Related PDB | 1jld |
| Related UniProtKB | P04584 |
| [16] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9209317 |
| Journal | Leukemia |
| Year | 1997 |
| Volume | 11 Suppl 3 |
| Pages | 120-2 |
| Authors | Pichova I, Weber J, Litera J, Konvalinka J, Vondrasek J, Soucek M, Strop P, Majer P, Heuser AM, Kraeusslich HG |
| Title | Peptide inhibitors of HIV-1 and HIV-2 proteases: a comparative study. |
| Related PDB | |
| Related UniProtKB | |
| [17] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9368756 |
| Journal | Curr Biol |
| Year | 1997 |
| Volume | 7 |
| Pages | 739-46 |
| Authors | Eijkelenboom AP, van den Ent FM, Vos A, Doreleijers JF, Hard K, Tullius TD, Plasterk RH, Kaptein R, Boelens R |
| Title | The solution structure of the amino-terminal HHCC domain of HIV-2 integrase: a three-helix bundle stabilized by zinc. |
| Related PDB | |
| Related UniProtKB | |
| [18] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9692985 |
| Journal | Biochemistry |
| Year | 1998 |
| Volume | 37 |
| Pages | 10928-36 |
| Authors | Swairjo MA, Towler EM, Debouck C, Abdel-Meguid SS |
| Title | Structural role of the 30's loop in determining the ligand specificity of the human immunodeficiency virus protease. |
| Related PDB | |
| Related UniProtKB | |
| [19] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9557677 |
| Journal | J Virol |
| Year | 1998 |
| Volume | 72 |
| Pages | 3916-24 |
| Authors | van den Ent FM, Vos A, Plasterk RH |
| Title | Mutational scan of the human immunodeficiency virus type 2 integrase protein. |
| Related PDB | |
| Related UniProtKB | |
| [20] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10491141 |
| Journal | Eur J Biochem |
| Year | 1999 |
| Volume | 264 |
| Pages | 921-9 |
| Authors | Boross P, Bagossi P, Copeland TD, Oroszlan S, Louis JM, Tozser J |
| Title | Effect of substrate residues on the P2' preference of retroviral proteinases. |
| Related PDB | |
| Related UniProtKB | |
| [21] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10631984 |
| Journal | Protein Sci |
| Year | 1999 |
| Volume | 8 |
| Pages | 2686-96 |
| Authors | Lescar J, Brynda J, Rezacova P, Stouracova R, Riottot MM, Chitarra V, Fabry M, Horejsi M, Sedlacek J, Bentley GA |
| Title | Inhibition of the HIV-1 and HIV-2 proteases by a monoclonal antibody. |
| Related PDB | |
| Related UniProtKB | |
| [22] | |
| Resource | |
| Comments | NMR structure |
| Medline ID | |
| PubMed ID | 11101216 |
| Journal | J Biomol NMR |
| Year | 2000 |
| Volume | 18 |
| Pages | 119-28 |
| Authors | Eijkelenboom AP, van den Ent FM, Wechselberger R, Plasterk RH, Kaptein R, Boelens R |
| Title | Refined solution structure of the dimeric N-terminal HHCC domain of HIV-2 integrase. |
| Related PDB | 1aub |
| Related UniProtKB | |
| [23] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11591344 |
| Journal | Structure (Camb) |
| Year | 2001 |
| Volume | 9 |
| Pages | 887-95 |
| Authors | Rezacova P, Lescar J, Brynda J, Fabry M, Horejsi M, Sedlacek J, Bentley GA |
| Title | Structural basis of HIV-1 and HIV-2 protease inhibition by a monoclonal antibody. |
| Related PDB | |
| Related UniProtKB | |
| [24] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12386343 |
| Journal | Proc Natl Acad Sci U S A |
| Year | 2002 |
| Volume | 99 |
| Pages | 14410-5 |
| Authors | Ren J, Bird LE, Chamberlain PP, Stewart-Jones GB, Stuart DI, Stammers DK |
| Title | Structure of HIV-2 reverse transcriptase at 2.35-A resolution and the mechanism of resistance to non-nucleoside inhibitors. |
| Related PDB | |
| Related UniProtKB | |
| [25] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12511797 |
| Journal | J Synchrotron Radiat |
| Year | 2003 |
| Volume | 10 |
| Pages | 86-95 |
| Authors | Feiters MC, Eijkelenboom AP, Nolting HF, Krebs B, van den Ent FM, Plasterk RH, Kaptein R, Boelens R |
| Title | X-ray absorption spectroscopic studies of zinc in the N-terminal domain of HIV-2 integrase and model compounds. |
| Related PDB | |
| Related UniProtKB | |
| [26] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 19132083 |
| Journal | PLoS Pathog |
| Year | 2009 |
| Volume | 5 |
| Pages | e1000259 |
| Authors | Hare S, Shun MC, Gupta SS, Valkov E, Engelman A, Cherepanov P |
| Title | A novel co-crystal structure affords the design of gain-of-function lentiviral integrase mutants in the presence of modified PSIP1/LEDGF/p75. |
| Related PDB | 3f9k |
| Related UniProtKB | |
| Comments |
|---|
|
The protein, This entry corresponds to the protease domain (residues 86-184), ### The protease domain form a homodimer to function as an enzyme. The homodimer of this domain contains a catalytic dyad, ### According to the literature [17], The paper [10] mentioned that zinc binding in this domain stabilizes its structure, ### On the other hand, Since the catalytic site of the reverse transcriptase (E.C. |
| Created | Updated |
|---|---|
| 2002-09-10 | 2012-06-29 |