RLCP 5.201.2781500.453 :EzCatDB EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms


R 5.-.-.- : Eliminative double-bond formation (bond cleavage and increased bond-order) (Reaction)

L 5.201.-.- : Amine group from Carbon (sp3) (with hydroxyl group) [leading to carbonyl group] (Ligand group involved)

C 5.201.2781500.- : Adenosine deaminase 2nd reaction step-like mechanism (Acid-Base/Stabilizer-Modulator); Inorganic cofactor-assisted stabilization of eliminated group; Modulator-assisted acid-base; Acid protonation to eliminated group leads to elimination; Base deprotonation of deprotonation site of leaving group; E1-like reaction (Catalytic mechanism)

P 5.201.2781500.453 : An acidic residue + His + zinc ion bound to His/(acidic residue) cluster (Residues/cofactors in Protein)

1st Nucleophile : non-existent
Catalytic groups : cofactor + groups in residue/substrate
General Base : a catalytic residue
General Acid : a catalytic residue

Related Enzymes

There are 2 entries in this class.
  • S00232 : (reaction 2) 3.5.4.4; Adenosine deaminase (Catalytic domain; 3.20.20.140)
  • D00873 : (reaction 2) 3.5.4.3; Guanine deaminase (Catalytic domain; 3.20.20.140)
    • Copyright: Nozomi Nagano, JST & CBRC-AIST
    Funded by PRESTO/Japan Science and Technology Agency (JST) (December 2001 - November 2004)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
    Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (September 2005 - September 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (October 2007 - September 2010)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2012 - March 2013)
    Supported by the commission for the Development of Artificial Gene Synthesis Technology for Creating Innovative Biomaterial from the Ministry of Economy, Trade and Industry (METI) (October 2012 - March 2016)
    Funded by the project commissioned by the New Energy and Industrial Technology Development Organization (NEDO) (April 2016 -)