RLCP 6.20.8000.6100 :EzCatDB EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms


R 6.-.-.- : Exchange of double-bonded atoms (Schiff-base related reaction) (Reaction)

L 6.20.-.- : Schiff-base nitrogen to Carbonyl oxygen (Schiff-base deformation; hydration) (Ligand group involved)

C 6.20.8000.- : Base-Acid/Base; Base activation of substituted group; Substituted group attacks on double-bond partner atom; Formation of tetrahedral intermediate; Covalently-bonded base deprotonates substituted group; Lone pair on substituted group attacks again on double-bond partner atom leading to bond cleavage; Acid protonation to leaving group (Catalytic mechanism)

P 6.20.8000.6100 : An acidic residue + Lys double-bonded to substrate/intermediate (Residues/cofactors in Protein)

1st Nucleophile : Substituted group (substrate or water)
Catalytic groups : groups in residue/substrate
General Base : a catalytic residue
General Acid : a catalytic residue

Related Enzymes

There is one entry in this class.
  • S00222 : (reaction 3) 4.1.2.14, 4.1.3.16; KHG/KDPG aldolase (Catalytic domain; 3.20.20.70)
    • Copyright: Nozomi Nagano, JST & CBRC-AIST
    Funded by PRESTO/Japan Science and Technology Agency (JST) (December 2001 - November 2004)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
    Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (September 2005 - September 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (October 2007 - September 2010)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2012 - March 2013)
    Supported by the commission for the Development of Artificial Gene Synthesis Technology for Creating Innovative Biomaterial from the Ministry of Economy, Trade and Industry (METI) (October 2012 - March 2016)
    Funded by the project commissioned by the New Energy and Industrial Technology Development Organization (NEDO) (April 2016 -)