DB code: M00332
| RLCP classification | 3.103.130000.1162 : Transfer | |
|---|---|---|
| CATH domain | -.-.-.- : | |
| 2.60.40.10 : Immunoglobulin-like | ||
| 2.60.40.10 : Immunoglobulin-like | ||
| 2.60.40.10 : Immunoglobulin-like | ||
| 2.60.40.10 : Immunoglobulin-like | ||
| -.-.-.- : | ||
| -.-.-.- : | ||
| 3.30.200.20 : Phosphorylase Kinase; domain 1 | ||
| 1.10.510.10 : Transferase(Phosphotransferase); domain 1 | Catalytic domain | |
| -.-.-.- : | ||
| E.C. | 2.7.10.1 | |
| CSA | ||
| M-CSA | ||
| MACiE | ||
| CATH domain | Related DB codes (homologues) |
|---|---|
| 1.10.510.10 : Transferase(Phosphotransferase); domain 1 | M00125 M00124 M00131 T00224 M00127 M00129 M00130 M00132 M00136 M00196 M00197 M00198 M00304 M00323 M00325 M00326 M00327 M00328 M00329 M00330 M00331 M00333 M00335 M00339 M00344 |
| 2.60.40.10 : Immunoglobulin-like | M00131 T00257 T00005 M00113 M00127 M00132 M00323 M00325 M00327 M00329 M00330 M00331 T00307 D00166 D00500 M00112 M00193 T00063 T00065 T00067 T00245 |
| 3.30.200.20 : Phosphorylase Kinase; domain 1 | M00125 M00124 M00131 T00224 M00127 M00129 M00130 M00132 M00136 M00196 M00197 M00198 M00304 M00323 M00325 M00326 M00327 M00328 M00329 M00330 M00331 M00333 M00335 M00339 M00344 D00298 |
| Uniprot Enzyme Name | UniprotKB | Protein name | Synonyms | RefSeq | MEROPS | Pfam |
|---|---|---|---|---|---|
| Q12866 |
Tyrosine-protein kinase Mer
|
EC
2.7.10.1
Proto-oncogene c-Mer Receptor tyrosine kinase MerTK |
NP_006334.2
(Protein)
NM_006343.2 (DNA/RNA sequence) |
I43.001
()
|
PF00041
(fn3)
PF07679 (I-set) PF07714 (Pkinase_Tyr) [Graphical View] |
| KEGG enzyme name |
|---|
|
Receptor protein-tyrosine kinase
ATP:protein-tyrosine O-phosphotransferase (ambiguous) MER MERTK Protein-tyrosine kinase (ambiguous) Protein tyrosine kinase (ambiguous) Receptor protein tyrosine kinase |
| UniprotKB: Accession Number | Entry name | Activity | Subunit | Subcellular location | Cofactor |
|---|---|---|---|---|---|
| Q12866 | MERTK_HUMAN | ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. | Interacts (upon activation) with TNK2, stimulates TNK2 autophosphorylation. Interacts (via N-terminus) with extracellular ligands LGALS3, TUB, TULP1 and GAS6 (By similarity). Interacts with VAV1 in a phosphotyrosine-independent manner. | Membrane, Single-pass type I membrane protein (By similarity). |
| KEGG Pathways | Map code | Pathways | E.C. |
|---|
| Compound table | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cofactors | Substrates | Products | Intermediates | ||||||||
| KEGG-id | C00305 | C00002 | C00585 | C00008 | C01167 | ||||||
| E.C. | |||||||||||
| Compound | Mg | ATP | [protein]-L-tyrosine | ADP | [protein]-L-tyrosine phosphate | ||||||
| Type | divalent metal (Ca2+, Mg2+) | amine group,nucleotide | aromatic ring (only carbon atom),peptide/protein | amine group,nucleotide | aromatic ring (only carbon atom),peptide/protein,phosphate group/phosphate ion | ||||||
| ChEBI |
18420 18420 |
15422 15422 |
16761 16761 |
||||||||
| PubChem |
888 888 |
5957 5957 |
6022 6022 |
||||||||
| 2dbjA00 |
|
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|
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|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2p0cA01 |
|
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|
Unbound | Analogue:ANP | Unbound | Unbound | Unbound | |
| 2p0cB01 |
|
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|
|
|
Unbound | Analogue:ANP | Unbound | Unbound | Unbound | |
| 3bprA01 |
|
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|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3bprB01 |
|
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|
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|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3bprC01 |
|
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|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3bprD01 |
|
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|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3brbA01 |
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|
Unbound | Unbound | Unbound | Bound:ADP | Unbound | |
| 3brbB01 |
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|
Unbound | Unbound | Unbound | Bound:ADP | Unbound | |
| 2p0cA02 |
|
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|
|
|
Bound:_MG | Unbound | Unbound | Unbound | Unbound | |
| 2p0cB02 |
|
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|
|
Bound:_MG | Unbound | Unbound | Unbound | Unbound | |
| 3bprA02 |
|
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|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3bprB02 |
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|
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|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3bprC02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3bprD02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3brbA02 |
|
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Bound:_MG | Unbound | Unbound | Unbound | Unbound | |
| 3brbB02 |
|
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|
|
Bound:_MG | Unbound | Unbound | Unbound | Unbound | |
| Reference for Active-site residues | ||
|---|---|---|
| resource | references | E.C. |
| Literature [4] & Swiss-prot;Q12866 | ||
| Active-site residues | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Catalytic residues | Cofactor-binding residues | Modified residues | Main-chain involved in catalysis | Comment | |||||
| 2dbjA00 |
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|||||
| 2p0cA01 |
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|
|
invisible 596-597, 622-632, 658-664 | ||||
| 2p0cB01 |
|
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|
invisible 596-598, 622-632, 658-664 | ||||
| 3bprA01 |
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invisible 623-628, 662-666 | ||||
| 3bprB01 |
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invisible 624-630, 660-666 | ||||
| 3bprC01 |
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invisible 623-630, 663-666 | ||||
| 3bprD01 |
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invisible 623-630, 662-666 | ||||
| 3brbA01 |
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invisible 622-624, 659-665 | ||||
| 3brbB01 |
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| 2p0cA02 |
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ASP 723;ARG 727 | ASN 728;ASP 741 (Magnesium binding) | invisible 745-762 | ||
| 2p0cB02 |
|
|
|
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|
ASP 723;ARG 727 | ASN 728;ASP 741 (Magnesium binding) | invisible 745-762 | ||
| 3bprA02 |
|
|
|
|
|
ASP 723;ARG 727 | ASN 728;ASP 741 (Magnesium binding) | invisible 746-762 | ||
| 3bprB02 |
|
|
|
|
|
ASP 723;ARG 727 | ASN 728;ASP 741 (Magnesium binding) | invisible 746-762 | ||
| 3bprC02 |
|
|
|
|
|
ASP 723;ARG 727 | ASN 728;ASP 741 (Magnesium binding) | invisible 746-762 | ||
| 3bprD02 |
|
|
|
|
|
ASP 723;ARG 727 | ASN 728;ASP 741 (Magnesium binding) | invisible 746-762 | ||
| 3brbA02 |
|
|
|
|
|
ASP 723;ARG 727 | ASN 728;ASP 741 (Magnesium binding) | invisible 746-761 | ||
| 3brbB02 |
|
|
|
|
|
ASP 723;ARG 727 | ASN 728;ASP 741 (Magnesium binding) | invisible 745-762 | ||
| References for Catalytic Mechanism | ||
|---|---|---|
| References | Sections | No. of steps in catalysis |
| References | |
|---|---|
| [1] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8702477 |
| Journal | J Biol Chem |
| Year | 1996 |
| Volume | 271 |
| Pages | 18355-62 |
| Authors | Ling L, Templeton D, Kung HJ |
| Title |
Identification of the major autophosphorylation sites of Nyk/Mer, |
| Related PDB | |
| Related UniProtKB | |
| [2] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9160883 |
| Journal | Oncogene |
| Year | 1997 |
| Volume | 14 |
| Pages | 2033-9 |
| Authors | Chen J, Carey K, Godowski PJ |
| Title |
Identification of Gas6 as a ligand for Mer, |
| Related PDB | |
| Related UniProtKB | |
| [3] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 16737840 |
| Journal | Cytokine Growth Factor Rev |
| Year | 2006 |
| Volume | 17 |
| Pages | 295-304 |
| Authors | Hafizi S, Dahlback B |
| Title | Signalling and functional diversity within the Axl subfamily of receptor tyrosine kinases. |
| Related PDB | |
| Related UniProtKB | |
| [4] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 19028587 |
| Journal | J Struct Biol |
| Year | 2009 |
| Volume | 165 |
| Pages | 88-96 |
| Authors | Huang X, Finerty P Jr, Walker JR, Butler-Cole C, Vedadi M, Schapira M, Parker SA, Turk BE, Thompson DA, Dhe-Paganon S |
| Title | Structural insights into the inhibited states of the Mer receptor tyrosine kinase. |
| Related PDB | 2p0c 3bpr 3brb |
| Related UniProtKB | Q12866 |
| Comments |
|---|
|
This enzyme belongs to Tyr protein kinase family.
The catalytic domain of this enzyme is homologous to that of vascular endothelial growth factor receptor (M00131 in EzCatDB). The extracellular region of this enzyme is composed of two immunoglobulin (Ig) repeats and two fibronectin type three (Fn-III) repeats (see [2] and [3]). |
| Created | Updated |
|---|---|
| 2011-11-17 | 2012-12-11 |