DB code: D00471
| RLCP classification | 1.13.200.966 : Hydrolysis | |
|---|---|---|
| CATH domain | 2.40.70.10 : Cathepsin D, subunit A; domain 1 | Catalytic domain |
| 2.40.70.10 : Cathepsin D, subunit A; domain 1 | Catalytic domain | |
| E.C. | 3.4.23.16 2.7.7.49 2.7.7.7 3.1.26.4 | |
| CSA | 1a30 1hiv | |
| M-CSA | 1a30 1hiv | |
| MACiE | M0175 | |
| CATH domain | Related DB codes (homologues) |
|---|---|
| 2.40.70.10 : Cathepsin D, subunit A; domain 1 | D00436 D00438 D00439 D00440 D00441 D00442 D00443 D00437 D00444 D00423 D00445 D00484 M00206 M00166 D00231 D00529 |
| Uniprot Enzyme Name | UniprotKB | Protein name | Synonyms | Contains | Pfam | RefSeq |
|---|---|---|---|---|---|
| P03366 |
Gag-Pol polyprotein
|
Pr160Gag-Pol
|
Matrix protein p17
(MA) Capsid protein p24 (CA) Spacer peptide p2 Nucleocapsid protein p7 (NC) Transframe peptide (TF) p6-pol (p6*) Protease EC 3.4.23.16 Retropepsin PR Reverse transcriptase/ribonuclease H EC 2.7.7.49 EC 2.7.7.7 EC 3.1.26.4 p66 RT p51 RT p15 Integrase (IN) |
PF00540
(Gag_p17)
PF00607 (Gag_p24) PF00552 (IN_DBD_C) PF02022 (Integrase_Zn) PF00075 (RNase_H) PF00665 (rve) PF00077 (RVP) PF00078 (RVT_1) PF06815 (RVT_connect) PF06817 (RVT_thumb) PF00098 (zf-CCHC) [Graphical View] |
|
| P04585 |
Gag-Pol polyprotein
|
Pr160Gag-Pol
|
Matrix protein p17
(MA) Capsid protein p24 (CA) Spacer peptide p2 Nucleocapsid protein p7 (NC) Transframe peptide (TF) p6-pol (p6*) Protease EC 3.4.23.16 Retropepsin PR Reverse transcriptase/ribonuclease H EC 2.7.7.49 EC 2.7.7.7 EC 3.1.26.4 p66 RT p51 RT p15 Integrase (IN) |
PF00540
(Gag_p17)
PF00607 (Gag_p24) PF00552 (IN_DBD_C) PF02022 (Integrase_Zn) PF00075 (RNase_H) PF00665 (rve) PF00077 (RVP) PF00078 (RVT_1) PF06815 (RVT_connect) PF06817 (RVT_thumb) PF00098 (zf-CCHC) [Graphical View] |
NP_057849.4
(Protein)
NC_001802.1 (DNA/RNA sequence) |
| P04587 |
Gag-Pol polyprotein
|
Pr160Gag-Pol
|
Matrix protein p17
(MA) Capsid protein p24 (CA) Spacer peptide p2 Nucleocapsid protein p7 (NC) Transframe peptide (TF) p6-pol (p6*) Protease EC 3.4.23.16 Retropepsin PR Reverse transcriptase/ribonuclease H EC 2.7.7.49 EC 2.7.7.7 EC 3.1.26.4 p66 RT p51 RT p15 Integrase (IN) |
PF00540
(Gag_p17)
PF00607 (Gag_p24) PF00552 (IN_DBD_C) PF02022 (Integrase_Zn) PF00075 (RNase_H) PF00665 (rve) PF00077 (RVP) PF00078 (RVT_1) PF06815 (RVT_connect) PF06817 (RVT_thumb) PF00098 (zf-CCHC) [Graphical View] |
|
| P35963 |
Gag-Pol polyprotein
|
Pr160Gag-Pol
|
Matrix protein p17
(MA) Capsid protein p24 (CA) Spacer peptide p2 Nucleocapsid protein p7 (NC) Transframe peptide (TF) p6-pol (p6*) Protease EC 3.4.23.16 Retropepsin PR Reverse transcriptase/ribonuclease H EC 2.7.7.49 EC 2.7.7.7 EC 3.1.26.4 p66 RT p51 RT p15 Integrase (IN) |
PF00540
(Gag_p17)
PF00607 (Gag_p24) PF00552 (IN_DBD_C) PF02022 (Integrase_Zn) PF00075 (RNase_H) PF00665 (rve) PF00077 (RVP) PF00078 (RVT_1) PF06815 (RVT_connect) PF06817 (RVT_thumb) PF00098 (zf-CCHC) [Graphical View] |
| KEGG enzyme name |
|---|
|
HIV-1 retropepsin
human immunodeficiency virus type 1 protease gag protease HIV aspartyl protease HIV proteinase retroproteinase HIV-1 protease HIV-2 protease |
| UniprotKB: Accession Number | Entry name | Activity | Subunit | Subcellular location | Cofactor |
|---|---|---|---|---|---|
| P03366 | POL_HV1B1 | Specific for a P1 residue that is hydrophobic, and P1'' variable, but often Pro. Endonucleolytic cleavage to 5''- phosphomonoester. Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). | Pre-integration complex interacts with human HMGA1. Matrix protein p17 is a trimer. Interacts with gp120 and human BAF. Capsid is a homodimer. Interacts with human PPIA/CYPA. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues. The reverse transcriptase is a heterodimer of p66 RT and p51 RT (RT p66/p51). Heterodimerization of RT is essential for DNA polymerase activity. Despite the sequence identities, p66 RT and p51 RT have distinct folding. Integrase is a homodimer and possibly can form homotetramer. Integrase interacts with human SMARCB1/INI1 and human PSIP1/LEDGF isoform 1 (By similarity). | Matrix protein p17: Virion (Potential). Nucleus (By similarity). Cytoplasm (By similarity). Cell membrane, Lipid-anchor (Potential). Note=Following virus entry, the nuclear localization signal (NLS) of the matrix protein participates with Vpr to the nuclear localization of the viral genome. During virus production, the nuclear export activity of the matrix protein counteracts the NLS to maintain the Gag and Gag-Pol polyproteins in the cytoplasm, thereby directing unspliced RNA to the plasma membrane (By similarity). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential). Nucleus (Potential). Cytoplasm (Potential). Note=Nuclear at initial phase, cytoplasmic at assembly (Potential). | Binds 2 magnesium ions for reverse transcriptase polymerase activity (By similarity). Binds 2 magnesium ions for ribonuclease H (RNase H) activity. Substrate-binding is a precondition for magnesium binding (By similarity). Magnesium ions for integrase activity. Binds at least 1, maybe 2 magnesium ions (By similarity). |
| P04585 | POL_HV1H2 | Specific for a P1 residue that is hydrophobic, and P1'' variable, but often Pro. Endonucleolytic cleavage to 5''- phosphomonoester. Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). | Pre-integration complex interacts with human HMGA1. Matrix protein p17 is a trimer. Interacts with gp120 and human BAF. Capsid is a homodimer. Interacts with human PPIA/CYPA. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues. The reverse transcriptase is a heterodimer of p66 RT and p51 RT (RT p66/p51). Heterodimerization of RT is essential for DNA polymerase activity. Despite the sequence identities, p66 RT and p51 RT have distinct folding. Integrase is a homodimer and possibly can form homotetramer. Integrase interacts with human SMARCB1/INI1 and human PSIP1/LEDGF isoform 1. | Matrix protein p17: Virion (Potential). Nucleus (By similarity). Cytoplasm (By similarity). Cell membrane, Lipid-anchor (Potential). Note=Following virus entry, the nuclear localization signal (NLS) of the matrix protein participates with Vpr to the nuclear localization of the viral genome. During virus production, the nuclear export activity of the matrix protein counteracts the NLS to maintain the Gag and Gag-Pol polyproteins in the cytoplasm, thereby directing unspliced RNA to the plasma membrane (By similarity). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential). Nucleus (Potential). Cytoplasm (Potential). Note=Nuclear at initial phase, cytoplasmic at assembly (Potential). | Binds 2 magnesium ions for reverse transcriptase polymerase activity (By similarity). Binds 2 magnesium ions for ribonuclease H (RNase H) activity. Substrate-binding is a precondition for magnesium binding (By similarity). Magnesium ions for integrase activity. Binds at least 1, maybe 2 magnesium ions (By similarity). |
| P04587 | POL_HV1B5 | Specific for a P1 residue that is hydrophobic, and P1'' variable, but often Pro. Endonucleolytic cleavage to 5''- phosphomonoester. Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). | Pre-integration complex interacts with human HMGA1. Matrix protein p17 is a trimer. Interacts with gp120 and human BAF. Capsid is a homodimer. Interacts with human PPIA/CYPA. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues. The reverse transcriptase is a heterodimer of p66 RT and p51 RT (RT p66/p51). Heterodimerization of RT is essential for DNA polymerase activity. Despite the sequence identities, p66 RT and p51 RT have distinct folding. Integrase is a homodimer and possibly can form homotetramer. Integrase interacts with human SMARCB1/INI1 and human PSIP1/LEDGF isoform 1 (By similarity). | Matrix protein p17: Virion (Potential). Nucleus (By similarity). Cytoplasm (By similarity). Cell membrane, Lipid-anchor (Potential). Note=Following virus entry, the nuclear localization signal (NLS) of the matrix protein participates with Vpr to the nuclear localization of the viral genome. During virus production, the nuclear export activity of the matrix protein counteracts the NLS to maintain the Gag and Gag-Pol polyproteins in the cytoplasm, thereby directing unspliced RNA to the plasma membrane (By similarity). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential). Nucleus (Potential). Cytoplasm (Potential). Note=Nuclear at initial phase, cytoplasmic at assembly (Potential). | Binds 2 magnesium ions for reverse transcriptase polymerase activity (By similarity). Binds 2 magnesium ions for ribonuclease H (RNase H) activity. Substrate-binding is a precondition for magnesium binding (By similarity). Magnesium ions for integrase activity. Binds at least 1, maybe 2 magnesium ions (By similarity). |
| P35963 | POL_HV1Y2 | Specific for a P1 residue that is hydrophobic, and P1'' variable, but often Pro. Endonucleolytic cleavage to 5''- phosphomonoester. Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). | Pre-integration complex interacts with human HMGA1. Matrix protein p17 is a trimer. Interacts with gp120 and human BAF. Capsid is a homodimer. Interacts with human PPIA/CYPA. The protease is a homodimer, whose active site consists of two apposed aspartic acid residues. The reverse transcriptase is a heterodimer of p66 RT and p51 RT (RT p66/p51). Heterodimerization of RT is essential for DNA polymerase activity. Despite the sequence identities, p66 RT and p51 RT have distinct folding. Integrase is a homodimer and possibly can form homotetramer. Integrase interacts with human SMARCB1/INI1 and human PSIP1/LEDGF isoform 1 (By similarity). | Matrix protein p17: Virion (Potential). Nucleus (By similarity). Cytoplasm (By similarity). Cell membrane, Lipid-anchor (Potential). Note=Following virus entry, the nuclear localization signal (NLS) of the matrix protein participates with Vpr to the nuclear localization of the viral genome. During virus production, the nuclear export activity of the matrix protein counteracts the NLS to maintain the Gag and Gag-Pol polyproteins in the cytoplasm, thereby directing unspliced RNA to the plasma membrane (By similarity). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential). Nucleus (Potential). Cytoplasm (Potential). Note=Nuclear at initial phase, cytoplasmic at assembly (Potential). | Binds 2 magnesium ions for reverse transcriptase polymerase activity (By similarity). Binds 2 magnesium ions for ribonuclease H (RNase H) activity. Substrate-binding is a precondition for magnesium binding (By similarity). Magnesium ions for integrase activity. Binds at least 1, maybe 2 magnesium ions (By similarity). |
| KEGG Pathways | Map code | Pathways | E.C. |
|---|
| Compound table | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Substrates | Products | Intermediates | |||||||||
| KEGG-id | C00017 | C00012 | C00001 | C00017 | C00012 | I00136 | |||||
| E.C. | |||||||||||
| Compound | Protein | Peptide | H2O | Protein | Peptide | Amino-diol-tetrahedral intermediate | |||||
| Type | peptide/protein | peptide/protein | H2O | peptide/protein | peptide/protein | ||||||
| ChEBI |
15377 15377 |
||||||||||
| PubChem |
22247451 962 22247451 962 |
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| 1a30A |
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Unbound | Analogue:GLU-ASP-LEU | Unbound | Unbound | Unbound | |
| 1ajvA |
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Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:NMB | |
| 1ajxA |
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Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:AH1 | |
| 1axaA |
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Unbound | Analogue:U0E-U0E | Unbound | Unbound | Unbound | |
| 1bdlA |
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Unbound | Unbound | Unbound | Analogue:IM1 | Unbound | |
| 1bdqA |
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Unbound | Analogue:IM1 | Unbound | Unbound | Unbound | |
| 1bdrA |
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Unbound | Analogue:IM1 | Unbound | Unbound | Unbound | |
| 1bv7A |
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Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:XV6 | |
| 1bv9A |
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Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:XV6 | |
| 1bveA |
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Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:DMP | |
| 1bvgA |
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Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:DMP | |
| 1bwaA |
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Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:XV6 | |
| 1bwbA |
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Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:146 | |
| 1d4hA |
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Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:BEH | |
| 1d4iA |
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Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:BEG | |
| 1d4jA |
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Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:MSC | |
| 1dmpA |
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Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:DMQ | |
| 1dw6C |
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Unbound | Analogue:ARG-VAL-DCL-PHE-GLU-ALA-NLN | Unbound | Unbound | Unbound | |
| 1ebkC |
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Unbound | Analogue:ARG-VAL-DCL-PHE-GLU-ALA-NLN | Unbound | Unbound | Unbound | |
| 1ebkE |
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Unbound | Analogue:ARG-VAL-DCL-PHE-GLU-ALA-NLN | Unbound | Unbound | Unbound | |
| 1ebwA |
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Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:BEI | |
| 1ebyA |
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Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:BEB | |
| 1ebzA |
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Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:BEC | |
| 1ec0A |
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Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:BED | |
| 1ec1A |
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Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:BEE | |
| 1ec2A |
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Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:BEJ | |
| 1ec3A |
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Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:MS3 | |
| 1fejC |
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Unbound | Analogue:ACE-THR-ILE-NLE-NLE-GLN-ARG | Unbound | Unbound | Unbound | |
| 1ff0C |
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Unbound | Analogue:ACE-THR-ILE-NLE-NLE-GLN-ARG | Unbound | Unbound | Unbound | |
| 1fffC |
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Unbound | Analogue:ARG-VAL-DCL-PHE-GLU-ALA-NLE-NH2 | Unbound | Unbound | Unbound | |
| 1ffiC |
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Unbound | Analogue:ACE-THR-ILE-NLE-NLE-GLN-ARG | Unbound | Unbound | Unbound | |
| 1fg6C |
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Unbound | Analogue:ACE-THR-ILE-NLE-NLE-GLN-ARG | Unbound | Unbound | Unbound | |
| 1fg8C |
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Unbound | Analogue:ARG-VAL-DCL-PHE-GLU-ALA-NLE-NH2 | Unbound | Unbound | Unbound | |
| 1fgcC |
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Unbound | Analogue:ACE-THR-ILE-NLE-NLE-GLN-ARG | Unbound | Unbound | Unbound | |
| 1g2kA |
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Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:NM1 | |
| 1g6lA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1gnnA |
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Unbound | Analogue:U0E-U0E | Unbound | Unbound | Unbound | |
| 1gnoA |
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Unbound | Analogue:U0E-U0E | Unbound | Unbound | Unbound | |
| 1hbvA |
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Unbound | Analogue:GAN | Unbound | Unbound | Unbound | |
| 1hefE |
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Unbound | Analogue:ALA-ALA-PHE-OHE-PHE-VAL-VAL-OME | Unbound | Unbound | Unbound | |
| 1hegE |
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Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1hihA |
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Unbound | Analogue:ALA-ALA-PHE-OHE-GLY-VAL-VAL-OME | Unbound | Unbound | Unbound | |
| 1hivA |
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Unbound | Analogue:C20 | Unbound | Unbound | Unbound | |
| 1hosA |
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Unbound | Analogue:NOA-HIS-CAV-ILE-APY | Unbound | Unbound | Transition-state-analogue:PHP | |
| 1hpsA |
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Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1hpvA |
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Unbound | Analogue:RUN-RUN | Unbound | Unbound | Unbound | |
| 1hteA |
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Unbound | Analogue:478 | Bound:LEU-GLN-GLU-SER | Analogue:G23 | Unbound | |
| 1htfA |
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Unbound | Unbound | Analogue:G26 | Unbound | Unbound | |
| 1htgA |
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Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1hvhA |
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Unbound | Analogue:G37 | Unbound | Unbound | Transition-state-analogue:Q82 | |
| 1hviA |
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Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:A77 | |
| 1hvjA |
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Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1hvkA |
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Unbound | Analogue:A78 | Unbound | Unbound | Transition-state-analogue:A79 | |
| 1hvlA |
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Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:A76 | |
| 1hvrA |
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Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:XK2 | |
| 1hvsA |
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Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:A77 | |
| 1hwrA |
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Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:216 | |
| 1hxbA |
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Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1k1tA |
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Unbound | Analogue:QNC-ASN-HPH-DIQ-NTB | Unbound | Unbound | Unbound | |
| 1k1uA |
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Unbound | Analogue:ARG-VAL-DCL-PHE-GLU-ALA-NLE | Unbound | Unbound | Unbound | |
| 1k2bA |
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Unbound | Analogue:ARG-VAL-DCL-PHE-GLU-ALA-NLE | Unbound | Unbound | Unbound | |
| 1k2cA |
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Unbound | Analogue:ARG-VAL-DCL-PHE-GLU-ALA-NLE-NH2 | Unbound | Unbound | Unbound | |
| 1k6cA |
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Unbound | Analogue:ARG-VAL-DCL-PHE-GLU-ALA-NLE-NH2 | Unbound | Unbound | Unbound | |
| 1k6pA |
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Unbound | Analogue:MK1 | Unbound | Unbound | Unbound | |
| 1k6tA |
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Unbound | Analogue:XN3 | Unbound | Unbound | Unbound | |
| 1k6vA |
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Unbound | Analogue:XN1 | Unbound | Unbound | Unbound | |
| 1lv1A01 |
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Unbound | Analogue:XN2 | Unbound | Unbound | Unbound | |
| 1merA |
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Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:DMQ | |
| 1mesA |
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Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:DMP | |
| 1metA |
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Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:DMP | |
| 1meuA |
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Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:DMP | |
| 1odwA |
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Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1odxA |
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Unbound | Analogue:BOC-HPH-DMN-HPH-BOC | Unbound | Unbound | Unbound | |
| 1odyA |
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Unbound | Analogue:BOC-HPH-DMN-HPH-BOC | Unbound | Unbound | Unbound | |
| 1qbrA |
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Unbound | Analogue:LP1 | Unbound | Unbound | Transition-state-analogue:XV6 | |
| 1qbsA |
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Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:DMP | |
| 1qbtA |
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Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:146 | |
| 1qbuA |
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Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:846 | |
| 1sbgA |
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Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1tcxA |
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Unbound | Analogue:IM1 | Unbound | Unbound | Unbound | |
| 2bpvA |
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Unbound | Analogue:IM1 | Unbound | Unbound | Unbound | |
| 2bpwA |
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Unbound | Analogue:1IN | Unbound | Unbound | Unbound | |
| 2bpxA |
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Unbound | Analogue:1IN | Unbound | Unbound | Unbound | |
| 2bpyA |
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Unbound | Analogue:MK1 | Unbound | Unbound | Unbound | |
| 2bpzA |
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Unbound | Analogue:3IN | Unbound | Unbound | Unbound | |
| 3phvA |
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Unbound | Analogue:3IN | Unbound | Unbound | Unbound | |
| 3tlhA |
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Unbound | Unbound | Unbound | Unbound | Unbound | |
| 9hvpA |
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Unbound | Analogue:INT | Unbound | Unbound | Unbound | |
| 1a30B |
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Unbound | Analogue:PHQ-VAL-COR-VAL-PHQ | Unbound | Unbound | Unbound | |
| 1ajvB |
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Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ajxB |
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Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1axaB |
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|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1bdlB |
|
|
|
|
|
Unbound | Unbound | Unbound | Analogue:IM1 | Unbound | |
| 1bdqB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1bdrB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1bv7B |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1bv9B |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1bveB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1bvgB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1bwaB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1bwbB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1d4hB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1d4iB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1d4jB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1dmpB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1dw6D |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ebkD |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ebkF |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ebwB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ebyB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ebzB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ec0B |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ec1B |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ec2B |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ec3B |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1fejD |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ff0D |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1fffD |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ffiD |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1fg6D |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1fg8D |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1fgcD |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1g2kB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1g6lA02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1gnnB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1gnoB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1hbvB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1hihB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1hivB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1hosB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1hpsB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1hpvB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1hteB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1htfB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1htgB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1hvhB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1hviB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1hvjB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1hvkB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1hvlB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1hvrB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1hvsB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1hwrB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1hxbB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1k1tB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1k1uB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1k2bB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1k2cB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1k6cB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1k6pB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1k6tB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1k6vB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1lv1A02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1merB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1mesB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1metB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1meuB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1odwB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1odxB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1odyB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qbrB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qbsB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qbtB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qbuB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1sbgB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1tcxB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2bpvB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2bpwB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2bpxB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2bpyB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2bpzB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| 9hvpB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | |
| Reference for Active-site residues | ||
|---|---|---|
| resource | references | E.C. |
| Swiss-prot;P35963 | ||
| Active-site residues | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Catalytic residues | Cofactor-binding residues | Modified residues | Main-chain involved in catalysis | Comment | |||||
| 1a30A |
|
|
|
|
|
ASP 25 | ||||
| 1ajvA |
|
|
|
|
|
ASP 25 | ||||
| 1ajxA |
|
|
|
|
|
ASP 25 | ||||
| 1axaA |
|
|
|
|
|
ASP 25 | mutant A28S | |||
| 1bdlA |
|
|
|
|
|
ASP 25 | mutant T31S, V32I, L33V, E34A, E35G, M36I, S37E | |||
| 1bdqA |
|
|
|
|
|
ASP 25 | mutant T31S, V32I, L33V, E34A, E35G, M36I, S37E, I47V, V82I | |||
| 1bdrA |
|
|
|
|
|
ASP 25 | mutant T31S, L33V, E34T, E35G, M36I, S37E | |||
| 1bv7A |
|
|
|
|
|
ASP 25 | ||||
| 1bv9A |
|
|
|
|
|
ASP 25 | mutant I84V | |||
| 1bveA |
|
|
|
|
|
ASP 25 | mutant C95A | |||
| 1bvgA |
|
|
|
|
|
ASP 25 | mutant C95A | |||
| 1bwaA |
|
|
|
|
|
ASP 25 | mutant V82F, I84V | |||
| 1bwbA |
|
|
|
|
|
ASP 25 | mutant V82F, I84V | |||
| 1d4hA |
|
|
|
|
|
ASP 25 | ||||
| 1d4iA |
|
|
|
|
|
ASP 25 | ||||
| 1d4jA |
|
|
|
|
|
ASP 25 | ||||
| 1dmpA |
|
|
|
|
|
ASP 25 | ||||
| 1dw6C |
|
|
|
|
|
ASP 25 | mutant Q7K, L33I, L63I, C67A, L90M, C95A | |||
| 1ebkC |
|
|
|
|
|
ASP 25 | mutant Q7K, R8Q, L33I, L63I, C67A, C95A | |||
| 1ebkE |
|
|
|
|
|
ASP 25 | mutant Q7K, R8Q, L33I, L63I, C67A, C95A | |||
| 1ebwA |
|
|
|
|
|
ASP 25 | ||||
| 1ebyA |
|
|
|
|
|
ASP 25 | ||||
| 1ebzA |
|
|
|
|
|
ASP 25 | ||||
| 1ec0A |
|
|
|
|
|
ASP 25 | ||||
| 1ec1A |
|
|
|
|
|
ASP 25 | ||||
| 1ec2A |
|
|
|
|
|
ASP 25 | ||||
| 1ec3A |
|
|
|
|
|
ASP 25 | ||||
| 1fejC |
|
|
|
|
|
ASP 25 | mutant L90M | |||
| 1ff0C |
|
|
|
|
|
ASP 25 | mutant K45I | |||
| 1fffC |
|
|
|
|
|
ASP 25 | mutant D30N | |||
| 1ffiC |
|
|
|
|
|
ASP 25 | mutant D30N | |||
| 1fg6C |
|
|
|
|
|
ASP 25 | mutant N88D | |||
| 1fg8C |
|
|
|
|
|
ASP 25 | mutant N88D | |||
| 1fgcC |
|
|
|
|
|
ASP 25 | ||||
| 1g2kA |
|
|
|
|
|
ASP 25 | ||||
| 1g6lA01 |
|
|
|
|
|
ASP 25 | ||||
| 1gnnA |
|
|
|
|
|
ASP 25 | mutant V82N | |||
| 1gnoA |
|
|
|
|
|
ASP 25 | ||||
| 1hbvA |
|
|
|
|
|
ASP 25 | ||||
| 1hefE |
|
|
|
|
|
ASP 25 | ||||
| 1hegE |
|
|
|
|
|
ASP 25 | ||||
| 1hihA |
|
|
|
|
|
ASP 25 | ||||
| 1hivA |
|
|
|
|
|
ASP 25 | ||||
| 1hosA |
|
|
|
|
|
ASP 25 | ||||
| 1hpsA |
|
|
|
|
|
ASP 25 | ||||
| 1hpvA |
|
|
|
|
|
ASP 25 | ||||
| 1hteA |
|
|
|
|
|
ASP 25 | ||||
| 1htfA |
|
|
|
|
|
ASP 25 | ||||
| 1htgA |
|
|
|
|
|
ASP 25 | ||||
| 1hvhA |
|
|
|
|
|
ASP 25 | ||||
| 1hviA |
|
|
|
|
|
ASP 25 | ||||
| 1hvjA |
|
|
|
|
|
ASP 25 | ||||
| 1hvkA |
|
|
|
|
|
ASP 25 | ||||
| 1hvlA |
|
|
|
|
|
ASP 25 | ||||
| 1hvrA |
|
|
|
|
|
ASP 25 | ||||
| 1hvsA |
|
|
|
|
|
ASP 25 | mutant V82A | |||
| 1hwrA |
|
|
|
|
|
ASP 25 | ||||
| 1hxbA |
|
|
|
|
|
ASP 25 | ||||
| 1k1tA |
|
|
|
|
|
ASP 25 | mutant K45I, V82S | |||
| 1k1uA |
|
|
|
|
|
ASP 25 | mutant K45I, L90M | |||
| 1k2bA |
|
|
|
|
|
ASP 25 | mutant N88D, L90M | |||
| 1k2cA |
|
|
|
|
|
ASP 25 | mutant D30N, V82S | |||
| 1k6cA |
|
|
|
|
|
ASP 25 | mutant Q7K, K14R, V82T, I84V | |||
| 1k6pA |
|
|
|
|
|
ASP 25 | mutant Q7K, K14R, V82T, I84V | |||
| 1k6tA |
|
|
|
|
|
ASP 25 | mutant Q7K, K14R, V82T, I84V | |||
| 1k6vA |
|
|
|
|
|
ASP 25 | mutant Q7K, K14R, V82T, I84V | |||
| 1lv1A01 |
|
|
|
|
|
ASP 25 | mutant C95M | |||
| 1merA |
|
|
|
|
|
ASP 25 | mutant I84V | |||
| 1mesA |
|
|
|
|
|
ASP 25 | mutant I84V | |||
| 1metA |
|
|
|
|
|
ASP 25 | mutant V82F | |||
| 1meuA |
|
|
|
|
|
ASP 25 | mutant V82F, I84V | |||
| 1odwA |
|
|
|
|
|
ASP 25 | ||||
| 1odxA |
|
|
|
|
|
ASP 25 | mutant A71T, V82A | |||
| 1odyA |
|
|
|
|
|
ASP 25 | ||||
| 1qbrA |
|
|
|
|
|
ASP 25 | ||||
| 1qbsA |
|
|
|
|
|
ASP 25 | ||||
| 1qbtA |
|
|
|
|
|
ASP 25 | ||||
| 1qbuA |
|
|
|
|
|
ASP 25 | ||||
| 1sbgA |
|
|
|
|
|
ASP 25 | ||||
| 1tcxA |
|
|
|
|
|
ASP 25 | mutant I32V, V47I, I82V | |||
| 2bpvA |
|
|
|
|
|
ASP 25 | ||||
| 2bpwA |
|
|
|
|
|
ASP 25 | ||||
| 2bpxA |
|
|
|
|
|
ASP 25 | ||||
| 2bpyA |
|
|
|
|
|
ASP 25 | ||||
| 2bpzA |
|
|
|
|
|
ASP 25 | ||||
| 3phvA |
|
|
|
|
|
ASP 25 | ||||
| 3tlhA |
|
|
|
|
|
ASP 25 | ||||
| 9hvpA |
|
|
|
|
|
ASP 25 | ||||
| 1a30B |
|
|
|
|
|
ASP 25 | ||||
| 1ajvB |
|
|
|
|
|
ASP 25 | ||||
| 1ajxB |
|
|
|
|
|
ASP 25 | ||||
| 1axaB |
|
|
|
|
|
ASP 25 | mutant A28S | |||
| 1bdlB |
|
|
|
|
|
ASP 25 | mutant T31S, V32I, L33V, E34A, E35G, M36I, S37E | |||
| 1bdqB |
|
|
|
|
|
ASP 25 | mutant T31S, V32I, L33V, E34A, E35G, M36I, S37E, I47V, V82I | |||
| 1bdrB |
|
|
|
|
|
ASP 25 | mutant T31S, L33V, E34T, E35G, M36I, S37E | |||
| 1bv7B |
|
|
|
|
|
ASP 25 | ||||
| 1bv9B |
|
|
|
|
|
ASP 25 | mutant I84V | |||
| 1bveB |
|
|
|
|
|
ASP 25 | mutant C95A | |||
| 1bvgB |
|
|
|
|
|
ASP 25 | mutant C95A | |||
| 1bwaB |
|
|
|
|
|
ASP 25 | mutant V82F, I84V | |||
| 1bwbB |
|
|
|
|
|
ASP 25 | mutant V82F, I84V | |||
| 1d4hB |
|
|
|
|
|
ASP 125 | ||||
| 1d4iB |
|
|
|
|
|
ASP 125 | ||||
| 1d4jB |
|
|
|
|
|
ASP 125 | ||||
| 1dmpB |
|
|
|
|
|
ASP 25 | ||||
| 1dw6D |
|
|
|
|
|
ASP 125 | mutant Q107K, L133I, L163I, C167A, L190M, C195A | |||
| 1ebkD |
|
|
|
|
|
ASP 125 | mutant Q107K, R108Q, L133I, L163I, C167A, C195A | |||
| 1ebkF |
|
|
|
|
|
ASP 125 | mutant Q107K, R108Q, L133I, L163I, C167A, C195A | |||
| 1ebwB |
|
|
|
|
|
ASP 125 | ||||
| 1ebyB |
|
|
|
|
|
ASP 125 | ||||
| 1ebzB |
|
|
|
|
|
ASP 125 | ||||
| 1ec0B |
|
|
|
|
|
ASP 125 | ||||
| 1ec1B |
|
|
|
|
|
ASP 125 | ||||
| 1ec2B |
|
|
|
|
|
ASP 125 | ||||
| 1ec3B |
|
|
|
|
|
ASP 125 | ||||
| 1fejD |
|
|
|
|
|
ASP 125 | mutant L190M | |||
| 1ff0D |
|
|
|
|
|
ASP 125 | mutant K145I | |||
| 1fffD |
|
|
|
|
|
ASP 125 | mutant D130N | |||
| 1ffiD |
|
|
|
|
|
ASP 125 | mutant D130N | |||
| 1fg6D |
|
|
|
|
|
ASP 125 | mutant N188D | |||
| 1fg8D |
|
|
|
|
|
ASP 125 | mutant N188D | |||
| 1fgcD |
|
|
|
|
|
ASP 125 | ||||
| 1g2kB |
|
|
|
|
|
ASP 25 | ||||
| 1g6lA02 |
|
|
|
|
|
ASP 1025 | ||||
| 1gnnB |
|
|
|
|
|
ASP 25 | mutant V82N | |||
| 1gnoB |
|
|
|
|
|
ASP 25 | ||||
| 1hbvB |
|
|
|
|
|
ASP 25 | ||||
| 1hihB |
|
|
|
|
|
ASP 25 | ||||
| 1hivB |
|
|
|
|
|
ASP 25 | ||||
| 1hosB |
|
|
|
|
|
ASP 25 | ||||
| 1hpsB |
|
|
|
|
|
ASP 25 | ||||
| 1hpvB |
|
|
|
|
|
ASP 25 | ||||
| 1hteB |
|
|
|
|
|
ASP 25 | ||||
| 1htfB |
|
|
|
|
|
ASP 25 | ||||
| 1htgB |
|
|
|
|
|
ASP 25 | ||||
| 1hvhB |
|
|
|
|
|
ASP 25 | ||||
| 1hviB |
|
|
|
|
|
ASP 25 | ||||
| 1hvjB |
|
|
|
|
|
ASP 25 | ||||
| 1hvkB |
|
|
|
|
|
ASP 25 | ||||
| 1hvlB |
|
|
|
|
|
ASP 25 | ||||
| 1hvrB |
|
|
|
|
|
ASP 25 | ||||
| 1hvsB |
|
|
|
|
|
ASP 25 | mutant V82A | |||
| 1hwrB |
|
|
|
|
|
ASP 25 | ||||
| 1hxbB |
|
|
|
|
|
ASP 25 | ||||
| 1k1tB |
|
|
|
|
|
ASP 125 | mutant K145I, V182S | |||
| 1k1uB |
|
|
|
|
|
ASP 125 | mutant K145I, L190M | |||
| 1k2bB |
|
|
|
|
|
ASP 25 | mutant N88D, L90M | |||
| 1k2cB |
|
|
|
|
|
ASP 25 | mutant D30N, V82S | |||
| 1k6cB |
|
|
|
|
|
ASP 25 | mutant Q7K, K14R, V82T, I84V | |||
| 1k6pB |
|
|
|
|
|
ASP 25 | mutant Q7K, K14R, V82T, I84V | |||
| 1k6tB |
|
|
|
|
|
ASP 25 | mutant Q7K, K14R, V82T, I84V | |||
| 1k6vB |
|
|
|
|
|
ASP 25 | mutant Q7K,K14R,V82T,I84V | |||
| 1lv1A02 |
|
|
|
|
|
ASP 1025 | mutant C1095A | |||
| 1merB |
|
|
|
|
|
ASP 25 | mutant I84V | |||
| 1mesB |
|
|
|
|
|
ASP 25 | mutant I84V | |||
| 1metB |
|
|
|
|
|
ASP 25 | mutant V82F | |||
| 1meuB |
|
|
|
|
|
ASP 25 | mutant V82F, I84V | |||
| 1odwB |
|
|
|
|
|
ASP 25 | ||||
| 1odxB |
|
|
|
|
|
ASP 25 | mutant A71T, V82A | |||
| 1odyB |
|
|
|
|
|
ASP 25 | ||||
| 1qbrB |
|
|
|
|
|
ASP 25 | ||||
| 1qbsB |
|
|
|
|
|
ASP 25 | ||||
| 1qbtB |
|
|
|
|
|
ASP 25 | ||||
| 1qbuB |
|
|
|
|
|
ASP 25 | ||||
| 1sbgB |
|
|
|
|
|
ASP 25 | ||||
| 1tcxB |
|
|
|
|
|
ASP 25 | mutant I32V, V47I, I82V | |||
| 2bpvB |
|
|
|
|
|
ASP 25 | ||||
| 2bpwB |
|
|
|
|
|
ASP 25 | ||||
| 2bpxB |
|
|
|
|
|
ASP 25 | ||||
| 2bpyB |
|
|
|
|
|
ASP 25 | ||||
| 2bpzB |
|
|
|
|
|
ASP 25 | ||||
| 9hvpB |
|
|
|
|
|
ASP 25 | ||||
| References for Catalytic Mechanism | ||
|---|---|---|
| References | Sections | No. of steps in catalysis |
|
[1]
|
p.302 | |
|
[7]
|
Fig.4, p.8461-8462 | |
|
[8]
|
p.1607-1608 | |
|
[9]
|
Fig.5, p.24363-24365 | |
|
[14]
|
p.7978-7979 | |
|
[33]
|
Fig.7, p.12942-12943 | |
|
[39]
|
Fig.17, p.336-339 | |
|
[40]
|
p.949 | |
|
[42]
|
p.682 | |
|
[79]
|
Fig.8, p.803 | |
|
[81]
|
Fig.1 | |
|
[100]
|
Fig.2 | |
| References | |
|---|---|
| [1] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 69-167. |
| Medline ID | 90044107 |
| PubMed ID | 2682266 |
| Journal | Nature |
| Year | 1989 |
| Volume | 342 |
| Pages | 299-302 |
| Authors | Lapatto R, Blundell T, Hemmings A, Overington J, Wilderspin A, Wood S, Merson JR, Whittle PJ, Danley DE, Geoghegan KF, et al |
| Title | X-ray analysis of HIV-1 proteinase at 2.7 A resolution confirms structural homology among retroviral enzymes. |
| Related PDB | 3phv |
| Related UniProtKB | P03366 |
| [2] | |
| Resource | |
| Comments | 3D-STRUCTURE MODELING OF PROTEASE DOMAIN. |
| Medline ID | 89146134 |
| PubMed ID | 2537531 |
| Journal | Science |
| Year | 1989 |
| Volume | 243 |
| Pages | 928-31 |
| Authors | Weber IT, Miller M, Jaskolski M, Leis J, Skalka AM, Wlodawer A |
| Title | Molecular modeling of the HIV-1 protease and its substrate binding site. |
| Related PDB | 1hvp |
| Related UniProtKB | P03366 |
| [3] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 2201682 |
| Journal | J Biol Chem |
| Year | 1990 |
| Volume | 265 |
| Pages | 14209-19 |
| Authors | Fitzgerald PM, McKeever BM, VanMiddlesworth JF, Springer JP, Heimbach JC, Leu CT, Herber WK, Dixon RA, Darke PL |
| Title | Crystallographic analysis of a complex between human immunodeficiency virus type 1 protease and acetyl-pepstatin at 2.0-A resolution. |
| Related PDB | |
| Related UniProtKB | |
| [4] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 2247458 |
| Journal | Proc Natl Acad Sci U S A |
| Year | 1990 |
| Volume | 87 |
| Pages | 8864-8 |
| Authors | Harte WE Jr, Swaminathan S, Mansuri MM, Martin JC, Rosenberg IE, Beveridge DL |
| Title | Domain communication in the dynamical structure of human immunodeficiency virus 1 protease. |
| Related PDB | |
| Related UniProtKB | |
| [5] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 69-167. |
| Medline ID | 90341771 |
| PubMed ID | 2200122 |
| Journal | Science |
| Year | 1990 |
| Volume | 249 |
| Pages | 527-33 |
| Authors | Erickson J, Neidhart DJ, VanDrie J, Kempf DJ, Wang XC, Norbeck DW, Plattner JJ, Rittenhouse JW, Turon M, Wideburg N, et al |
| Title |
Design, |
| Related PDB | 9hvp |
| Related UniProtKB | P03366 |
| [6] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1812742 |
| Journal | Adv Exp Med Biol |
| Year | 1991 |
| Volume | 306 |
| Pages | 455-60 |
| Authors | Graves BJ, Hatada MH, Miller JK, Graves MC, Roy S, Cook CM, Krohn A, Martin JA, Roberts NA |
| Title | The three-dimensional x-ray crystal structure of HIV-1 protease complexed with a hydroxyethylene inhibitor. |
| Related PDB | |
| Related UniProtKB | |
| [7] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1883831 |
| Journal | Biochemistry |
| Year | 1991 |
| Volume | 30 |
| Pages | 8454-63 |
| Authors | Hyland LJ, Tomaszek TA Jr, Meek TD |
| Title |
Human immunodeficiency virus-1 protease. |
| Related PDB | |
| Related UniProtKB | |
| [8] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1993177 |
| Journal | Biochemistry |
| Year | 1991 |
| Volume | 30 |
| Pages | 1600-9 |
| Authors | Jaskolski M, Tomasselli AG, Sawyer TK, Staples DG, Heinrikson RL, Schneider J, Kent SB, Wlodawer A |
| Title | Structure at 2.5-A resolution of chemically synthesized human immunodeficiency virus type 1 protease complexed with a hydroxyethylene-based inhibitor. |
| Related PDB | |
| Related UniProtKB | |
| [9] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1761538 |
| Journal | J Biol Chem |
| Year | 1991 |
| Volume | 266 |
| Pages | 24359-66 |
| Authors | Ido E, Han HP, Kezdy FJ, Tang J |
| Title | Kinetic studies of human immunodeficiency virus type 1 protease and its active-site hydrogen bond mutant A28S. |
| Related PDB | |
| Related UniProtKB | |
| [10] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 1956054 |
| Journal | J Med Chem |
| Year | 1991 |
| Volume | 34 |
| Pages | 3340-2 |
| Authors | Krohn A, Redshaw S, Ritchie JC, Graves BJ, Hatada MH |
| Title | Novel binding mode of highly potent HIV-proteinase inhibitors incorporating the (R)-hydroxyethylamine isostere. |
| Related PDB | 1hxb |
| Related UniProtKB | |
| [11] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 1429626 |
| Journal | J Biol Chem |
| Year | 1992 |
| Volume | 267 |
| Pages | 22770-8 |
| Authors | Murthy KH, Winborne EL, Minnich MD, Culp JS, Debouck C |
| Title | The crystal structures at 2.2-A resolution of hydroxyethylene-based inhibitors bound to human immunodeficiency virus type 1 protease show that the inhibitors are present in two distinct orientations. |
| Related PDB | 1heg |
| Related UniProtKB | |
| [12] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 1304383 |
| Journal | Protein Sci |
| Year | 1992 |
| Volume | 1 |
| Pages | 1061-72 |
| Authors | Thanki N, Rao JK, Foundling SI, Howe WJ, Moon JB, Hui JO, Tomasselli AG, Heinrikson RL, Thaisrivongs S, Wlodawer A |
| Title | Crystal structure of a complex of HIV-1 protease with a dihydroxyethylene-containing inhibitor: comparisons with molecular modeling. |
| Related PDB | 1hiv |
| Related UniProtKB | |
| [13] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8352596 |
| Journal | Annu Rev Biochem |
| Year | 1993 |
| Volume | 62 |
| Pages | 543-85 |
| Authors | Wlodawer A, Erickson JW |
| Title | Structure-based inhibitors of HIV-1 protease. |
| Related PDB | |
| Related UniProtKB | |
| [14] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 8347601 |
| Journal | Biochemistry |
| Year | 1993 |
| Volume | 32 |
| Pages | 7972-80 |
| Authors | Abdel-Meguid SS, Zhao B, Murthy KH, Winborne E, Choi JK, DesJarlais RL, Minnich MD, Culp JS, Debouck C, Tomaszek TA Jr, et al |
| Title |
Inhibition of human immunodeficiency virus-1 protease by a C2-symmetric phosphinate. |
| Related PDB | 1hos |
| Related UniProtKB | |
| [15] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 7918383 |
| Journal | Biochemistry |
| Year | 1994 |
| Volume | 33 |
| Pages | 11671-7 |
| Authors | Abdel-Meguid SS, Metcalf BW, Carr TJ, Demarsh P, DesJarlais RL, Fisher S, Green DW, Ivanoff L, Lambert DM, Murthy KH, et al |
| Title | An orally bioavailable HIV-1 protease inhibitor containing an imidazole-derived peptide bond replacement: crystallographic and pharmacokinetic analysis. |
| Related PDB | 1sbg |
| Related UniProtKB | |
| [16] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 8031777 |
| Journal | Biochemistry |
| Year | 1994 |
| Volume | 33 |
| Pages | 8417-27 |
| Authors | Jhoti H, Singh OM, Weir MP, Cooke R, Murray-Rust P, Wonacott A |
| Title | X-ray crystallographic studies of a series of penicillin-derived asymmetric inhibitors of HIV-1 protease. |
| Related PDB | 1hte 1htf 1htg |
| Related UniProtKB | |
| [17] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | |
| Journal | J Am Chem Soc |
| Year | 1994 |
| Volume | 116 |
| Pages | 847-55 |
| Authors | Hosur MV, Bhat TN, Kempf DJ, Baldwin ET, Liu B, Gulnik S, Wideburg NE, Norbeck DW, Appelt K, Erickson JW |
| Title | Influence of stereochemistry on activity and binding modes for C2 symmetry-based diol inhibitors of HIV-1 protease. |
| Related PDB | 1hvi 1hvj 1hvk 1hvl |
| Related UniProtKB | |
| [18] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 7932533 |
| Journal | J Med Chem |
| Year | 1994 |
| Volume | 37 |
| Pages | 3100-7 |
| Authors | Thompson SK, Murthy KH, Zhao B, Winborne E, Green DW, Fisher SM, DesJarlais RL, Tomaszek TA Jr, Meek TD, Gleason JG, et al |
| Title |
Rational design, |
| Related PDB | 1hps |
| Related UniProtKB | |
| [19] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 8278812 |
| Journal | Science |
| Year | 1994 |
| Volume | 263 |
| Pages | 380-4 |
| Authors | Lam PY, Jadhav PK, Eyermann CJ, Hodge CN, Ru Y, Bacheler LT, Meek JL, Otto MJ, Rayner MM, Wong YN, et al |
| Title |
Rational design of potent, |
| Related PDB | 1hvr |
| Related UniProtKB | |
| [20] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8540354 |
| Journal | Adv Exp Med Biol |
| Year | 1995 |
| Volume | 362 |
| Pages | 439-44 |
| Authors | Bhat TN, Baldwin ET, Liu B, Cheng YS, Erickson JW |
| Title | X-ray structure of a tethered dimer for HIV-1 protease. |
| Related PDB | |
| Related UniProtKB | |
| [21] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8540357 |
| Journal | Adv Exp Med Biol |
| Year | 1995 |
| Volume | 362 |
| Pages | 455-60 |
| Authors | Collins JR, Burt SK, Erickson JW |
| Title | Activated dynamics of flap opening in HIV-1 protease. |
| Related PDB | |
| Related UniProtKB | |
| [22] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8540356 |
| Journal | Adv Exp Med Biol |
| Year | 1995 |
| Volume | 362 |
| Pages | 451-4 |
| Authors | Silva AM, Cachau RE, Baldwin ET, Gulnik S, Sham HL, Erickson JW |
| Title | Molecular dynamics of HIV-1 protease in complex with a difluoroketone-containing inhibitor: implications for the catalytic mechanism. |
| Related PDB | |
| Related UniProtKB | |
| [23] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9383433 |
| Journal | Chem Biol |
| Year | 1995 |
| Volume | 2 |
| Pages | 317-24 |
| Authors | Gehlhaar DK, Verkhivker GM, Rejto PA, Sherman CJ, Fogel DB, Fogel LJ, Freer ST |
| Title | Molecular recognition of the inhibitor AG-1343 by HIV-1 protease: conformationally flexible docking by evolutionary programming. |
| Related PDB | |
| Related UniProtKB | |
| [24] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | |
| Journal | J Am Chem Soc |
| Year | 1995 |
| Volume | 117 |
| Pages | 1181-2 |
| Authors | Kim E.E, Baker CT, Dwyer MD, Murcko MA, Rao BG, Tung RD, Navia MA |
| Title |
Crystal structure of HIV-1 protease in complex with VX-478, |
| Related PDB | 1hpv |
| Related UniProtKB | |
| [25] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7665551 |
| Journal | J Biol Chem |
| Year | 1995 |
| Volume | 270 |
| Pages | 21433-6 |
| Authors | Chen Z, Li Y, Schock HB, Hall D, Chen E, Kuo LC |
| Title | Three-dimensional structure of a mutant HIV-1 protease displaying cross-resistance to all protease inhibitors in clinical trials. |
| Related PDB | |
| Related UniProtKB | |
| [26] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 7650677 |
| Journal | J Med Chem |
| Year | 1995 |
| Volume | 38 |
| Pages | 3246-52 |
| Authors | Hoog SS, Zhao B, Winborne E, Fisher S, Green DW, DesJarlais RL, Newlander KA, Callahan JF, Moore ML, Huffman WF, et al |
| Title | A check on rational drug design: crystal structure of a complex of human immunodeficiency virus type 1 protease with a novel gamma-turn mimetic inhibitor. |
| Related PDB | 1hef |
| Related UniProtKB | |
| [27] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7796263 |
| Journal | Nat Struct Biol |
| Year | 1995 |
| Volume | 2 |
| Pages | 274-80 |
| Authors | Nicholson LK, Yamazaki T, Torchia DA, Grzesiek S, Bax A, Stahl SJ, Kaufman JD, Wingfield PT, Lam PY, Jadhav PK, et al |
| Title | Flexibility and function in HIV-1 protease. |
| Related PDB | |
| Related UniProtKB | |
| [28] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8590019 |
| Journal | Structure |
| Year | 1995 |
| Volume | 3 |
| Pages | 581-90 |
| Authors | Baldwin ET, Bhat TN, Gulnik S, Liu B, Topol IA, Kiso Y, Mimoto T, Mitsuya H, Erickson JW |
| Title |
Structure of HIV-1 protease with KNI-272, |
| Related PDB | |
| Related UniProtKB | |
| [29] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 7613867 |
| Journal | Structure |
| Year | 1995 |
| Volume | 3 |
| Pages | 381-9 |
| Authors | Priestle JP, Fassler A, Rosel J, Tintelnot-Blomley M, Strop P, Grutter MG |
| Title |
Comparative analysis of the X-ray structures of HIV-1 and HIV-2 proteases in complex with CGP 53820, |
| Related PDB | 1hih |
| Related UniProtKB | |
| [30] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8652592 |
| Journal | Biochemistry |
| Year | 1996 |
| Volume | 35 |
| Pages | 2482-8 |
| Authors | Davis DA, Dorsey K, Wingfield PT, Stahl SJ, Kaufman J, Fales HM, Levine RL |
| Title | Regulation of HIV-1 protease activity through cysteine modification. |
| Related PDB | |
| Related UniProtKB | |
| [31] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 8718851 |
| Journal | Biochemistry |
| Year | 1996 |
| Volume | 35 |
| Pages | 10627-33 |
| Authors | Hong L, Treharne A, Hartsuck JA, Foundling S, Tang J |
| Title | Crystal structures of complexes of a peptidic inhibitor with wild-type and two mutant HIV-1 proteases. |
| Related PDB | 1gnn 1gno |
| Related UniProtKB | |
| [32] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 8756683 |
| Journal | Biochemistry |
| Year | 1996 |
| Volume | 35 |
| Pages | 10279-86 |
| Authors | Hoog SS, Towler EM, Zhao B, Doyle ML, Debouck C, Abdel-Meguid SS |
| Title | Human immunodeficiency virus protease ligand specificity conferred by residues outside of the active site cavity. |
| Related PDB | 1tcx |
| Related UniProtKB | |
| [33] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8841139 |
| Journal | Biochemistry |
| Year | 1996 |
| Volume | 35 |
| Pages | 12933-44 |
| Authors | Rose RB, Craik CS, Douglas NL, Stroud RM |
| Title | Three-dimensional structures of HIV-1 and SIV protease product complexes. |
| Related PDB | |
| Related UniProtKB | |
| [34] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8756455 |
| Journal | Biochemistry |
| Year | 1996 |
| Volume | 35 |
| Pages | 9945-50 |
| Authors | Wang YX, Freedberg DI, Yamazaki T, Wingfield PT, Stahl SJ, Kaufman JD, Kiso Y, Torchia DA |
| Title | Solution NMR evidence that the HIV-1 protease catalytic aspartyl groups have different ionization states in the complex formed with the asymmetric drug KNI-272. |
| Related PDB | |
| Related UniProtKB | |
| [35] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 8807858 |
| Journal | Chem Biol |
| Year | 1996 |
| Volume | 3 |
| Pages | 301-14 |
| Authors | Hodge CN, Aldrich PE, Bacheler LT, Chang CH, Eyermann CJ, Garber S, Grubb M, Jackson DA, Jadhav PK, Korant B, Lam PY, Maurin MB, Meek JL, Otto MJ, Rayner MM, Reid C, Sharpe TR, Shum L, Winslow DL, Erickson-Viitanen S |
| Title |
Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, |
| Related PDB | 1dmp |
| Related UniProtKB | |
| [36] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8621402 |
| Journal | J Biol Chem |
| Year | 1996 |
| Volume | 271 |
| Pages | 5458-63 |
| Authors | Szeltner Z, Polgar L |
| Title | Conformational stability and catalytic activity of HIV-1 protease are both enhanced at high salt concentration. |
| Related PDB | |
| Related UniProtKB | |
| [37] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 8784449 |
| Journal | J Med Chem |
| Year | 1996 |
| Volume | 39 |
| Pages | 3514-25 |
| Authors | Lam PY, Ru Y, Jadhav PK, Aldrich PE, DeLucca GV, Eyermann CJ, Chang CH, Emmett G, Holler ER, Daneker WF, Li L, Confalone PN, McHugh RJ, Han Q, Li R, Markwalder JA, Seitz SP, Sharpe TR, Bacheler LT, Rayner MM, Klabe RM, Shum L, Winslow DL, Kornhauser DM, Hodge CN, et al |
| Title |
Cyclic HIV protease inhibitors: synthesis, |
| Related PDB | 1qbs |
| Related UniProtKB | |
| [38] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8667359 |
| Journal | J Med Chem |
| Year | 1996 |
| Volume | 39 |
| Pages | 2156-69 |
| Authors | Nugiel DA, Jacobs K, Kaltenbach RF, Worley T, Patel M, Meyer DT, Jadhav PK, De Lucca GV, Smyser TE, Klabe RM, Bacheler LT, Rayner MM, Seitz SP |
| Title | Preparation and structure-activity relationship of novel P1/P1'-substituted cyclic urea-based human immunodeficiency virus type-1 protease inhibitors. |
| Related PDB | |
| Related UniProtKB | |
| [39] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8551523 |
| Journal | J Mol Biol |
| Year | 1996 |
| Volume | 255 |
| Pages | 321-46 |
| Authors | Silva AM, Cachau RE, Sham HL, Erickson JW |
| Title | Inhibition and catalytic mechanism of HIV-1 aspartic protease. |
| Related PDB | |
| Related UniProtKB | |
| [40] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8901873 |
| Journal | Nat Struct Biol |
| Year | 1996 |
| Volume | 3 |
| Pages | 946-50 |
| Authors | Smith R, Brereton IM, Chai RY, Kent SB |
| Title | Ionization states of the catalytic residues in HIV-1 protease. |
| Related PDB | |
| Related UniProtKB | |
| [41] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9390264 |
| Journal | Pac Symp Biocomput |
| Year | 1996 |
| Volume | |
| Pages | 638-52 |
| Authors | Verkhivker GM |
| Title |
Empirical free energy calculations of human immunodeficiency virus type 1 protease crystallographic complexes. |
| Related PDB | |
| Related UniProtKB | |
| [42] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8875645 |
| Journal | Protein Eng |
| Year | 1996 |
| Volume | 9 |
| Pages | 679-90 |
| Authors | Weber IT, Harrison RW |
| Title | Molecular mechanics calculations on HIV-1 protease with peptide substrates correlate with experimental data. |
| Related PDB | |
| Related UniProtKB | |
| [43] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | |
| Journal | Protein Pept Lett |
| Year | 1996 |
| Volume | 3 |
| Pages | 399-406 |
| Authors | Kervinen J, Thanki N, Zdanov A, Tino J, Barrish J, Pin FL, Colonno R, Riccardi K, Samanta H, Wlodawer A |
| Title | Structural Analysis of the Native and Drug-Resistant HIV-1 Proteinases Complexed with an Aminodiol Inhibitor. |
| Related PDB | 1odx |
| Related UniProtKB | |
| [44] | |
| Resource | |
| Comments | STRUCTURE BY NMR OF 57-155. |
| Medline ID | 97022126 |
| PubMed ID | 8868486 |
| Journal | Protein Sci |
| Year | 1996 |
| Volume | 5 |
| Pages | 495-506 |
| Authors | Yamazaki T, Hinck AP, Wang YX, Nicholson LK, Torchia DA, Wingfield P, Stahl SJ, Kaufman JD, Chang CH, Domaille PJ, Lam PY |
| Title |
Three-dimensional solution structure of the HIV-1 protease complexed with DMP323, |
| Related PDB | 1bve 1bvg |
| Related UniProtKB | P04585 |
| [45] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 9048541 |
| Journal | Biochemistry |
| Year | 1997 |
| Volume | 36 |
| Pages | 1573-80 |
| Authors | Ala PJ, Huston EE, Klabe RM, McCabe DD, Duke JL, Rizzo CJ, Korant BD, DeLoskey RJ, Lam PY, Hodge CN, Chang CH |
| Title | Molecular basis of HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with cyclic urea inhibitors. |
| Related PDB | 1mer 1mes 1met 1meu |
| Related UniProtKB | |
| [46] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9346283 |
| Journal | Eur J Biochem |
| Year | 1997 |
| Volume | 248 |
| Pages | 313-22 |
| Authors | Lange-Savage G, Berchtold H, Liesum A, Budt KH, Peyman A, Knolle J, Sedlacek J, Fabry M, Hilgenfeld R |
| Title | Structure of HOE/BAY 793 complexed to human immunodeficiency virus (HIV-1) protease in two different crystal forms--structure/function relationship and influence of crystal packing. |
| Related PDB | |
| Related UniProtKB | |
| [47] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9188447 |
| Journal | J Biol Chem |
| Year | 1997 |
| Volume | 272 |
| Pages | 15603-6 |
| Authors | Vance JE, LeBlanc DA, Wingfield P, London RE |
| Title | Conformational selectivity of HIV-1 protease cleavage of X-Pro peptide bonds and its implications. |
| Related PDB | |
| Related UniProtKB | |
| [48] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 9083478 |
| Journal | J Med Chem |
| Year | 1997 |
| Volume | 40 |
| Pages | 898-902 |
| Authors | Backbro K, Lowgren S, Osterlund K, Atepo J, Unge T, Hulten J, Bonham NM, Schaal W, Karlen A, Hallberg A |
| Title | Unexpected binding mode of a cyclic sulfamide HIV-1 protease inhibitor. |
| Related PDB | 1ajv 1ajx |
| Related UniProtKB | |
| [49] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 9003516 |
| Journal | J Med Chem |
| Year | 1997 |
| Volume | 40 |
| Pages | 181-91 |
| Authors | Jadhav PK, Ala P, Woerner FJ, Chang CH, Garber SS, Anton ED, Bacheler LT |
| Title | Cyclic urea amides: HIV-1 protease inhibitors with low nanomolar potency against both wild type and protease inhibitor resistant mutants of HIV. |
| Related PDB | 1qbr 1qbt 1qbu |
| Related UniProtKB | |
| [50] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9258349 |
| Journal | J Med Chem |
| Year | 1997 |
| Volume | 40 |
| Pages | 2440-4 |
| Authors | Smith AB 3rd, Hirschmann R, Pasternak A, Yao W, Sprengeler PA, Holloway MK, Kuo LC, Chen Z, Darke PL, Schleif WA |
| Title | An orally bioavailable pyrrolinone inhibitor of HIV-1 protease: computational analysis and X-ray crystal structure of the enzyme complex. |
| Related PDB | |
| Related UniProtKB | |
| [51] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9061782 |
| Journal | Proteins |
| Year | 1997 |
| Volume | 27 |
| Pages | 184-94 |
| Authors | Miller M, Geller M, Gribskov M, Kent SB |
| Title |
Analysis of the structure of chemically synthesized HIV-1 protease complexed with a hexapeptide inhibitor. |
| Related PDB | |
| Related UniProtKB | |
| [52] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 9757136 |
| Journal | Acta Crystallogr D Biol Crystallogr |
| Year | 1998 |
| Volume | 54 |
| Pages | 1053-60 |
| Authors | Munshi S, Chen Z, Li Y, Olsen DB, Fraley ME, Hungate RW, Kuo LC |
| Title | Rapid X-ray diffraction analysis of HIV-1 protease-inhibitor complexes: inhibitor exchange in single crystals of the bound enzyme. |
| Related PDB | 2bpv 2bpw 2bpx 2bpy 2bpz |
| Related UniProtKB | |
| [53] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9561200 |
| Journal | Adv Exp Med Biol |
| Year | 1998 |
| Volume | 436 |
| Pages | 59-63 |
| Authors | Hong L, Zhang C, Hartsuck JA, Foundling S, Tang J |
| Title | X-ray crystallographic studies of the structure-function relationships of HIV-1 protease. |
| Related PDB | |
| Related UniProtKB | |
| [54] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 9790666 |
| Journal | Biochemistry |
| Year | 1998 |
| Volume | 37 |
| Pages | 15042-9 |
| Authors | Ala PJ, Huston EE, Klabe RM, Jadhav PK, Lam PY, Chang CH |
| Title |
Counteracting HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with XV638 and SD146, |
| Related PDB | 1bv7 1bv9 1bwa 1bwb |
| Related UniProtKB | |
| [55] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 9485357 |
| Journal | Biochemistry |
| Year | 1998 |
| Volume | 37 |
| Pages | 2105-10 |
| Authors | Louis JM, Dyda F, Nashed NT, Kimmel AR, Davies DR |
| Title | Hydrophilic peptides derived from the transframe region of Gag-Pol inhibit the HIV-1 protease. |
| Related PDB | 1a30 |
| Related UniProtKB | |
| [56] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 9692985 |
| Journal | Biochemistry |
| Year | 1998 |
| Volume | 37 |
| Pages | 10928-36 |
| Authors | Swairjo MA, Towler EM, Debouck C, Abdel-Meguid SS |
| Title | Structural role of the 30's loop in determining the ligand specificity of the human immunodeficiency virus protease. |
| Related PDB | 1bdr |
| Related UniProtKB | |
| [57] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9860826 |
| Journal | Biochemistry |
| Year | 1998 |
| Volume | 37 |
| Pages | 17137-44 |
| Authors | Towler EM, Gulnik SV, Bhat TN, Xie D, Gustschina E, Sumpter TR, Robertson N, Jones C, Sauter M, Mueller-Lantzsch N, Debouck C, Erickson JW |
| Title |
Functional characterization of the protease of human endogenous retrovirus, |
| Related PDB | |
| Related UniProtKB | |
| [58] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9881109 |
| Journal | Bioorg Med Chem |
| Year | 1998 |
| Volume | 6 |
| Pages | 2185-92 |
| Authors | Gupta SP, Babu MS, Sowmya S |
| Title | A quantitative structure-activity relationship study on some sulfolanes and arylthiomethanes acting as HIV-1 protease inhibitors. |
| Related PDB | |
| Related UniProtKB | |
| [59] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9789740 |
| Journal | Gen Physiol Biophys |
| Year | 1998 |
| Volume | 17 Suppl 1 |
| Pages | 3-6 |
| Authors | Lescar J, Stouracova R, Riottot MM, Chitarra V, Brynda J, Fabry M, Horejsi M, Sedlacek J, Bentley GA |
| Title | Structural studies of HIV-1 protease-inhibiting antibodies. |
| Related PDB | |
| Related UniProtKB | |
| [60] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 9575185 |
| Journal | J Biol Chem |
| Year | 1998 |
| Volume | 273 |
| Pages | 12325-31 |
| Authors | Ala PJ, DeLoskey RJ, Huston EE, Jadhav PK, Lam PY, Eyermann CJ, Hodge CN, Schadt MC, Lewandowski FA, Weber PC, McCabe DD, Duke JL, Chang CH |
| Title | Molecular recognition of cyclic urea HIV-1 protease inhibitors. |
| Related PDB | 1hwr |
| Related UniProtKB | |
| [61] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 9554878 |
| Journal | J Med Chem |
| Year | 1998 |
| Volume | 41 |
| Pages | 1446-55 |
| Authors | Jadhav PK, Woerner FJ, Lam PY, Hodge CN, Eyermann CJ, Man HW, Daneker WF, Bacheler LT, Rayner MM, Meek JL, Erickson-Viitanen S, Jackson DA, Calabrese JC, Schadt M, Chang CH |
| Title |
Nonpeptide cyclic cyanoguanidines as HIV-1 protease inhibitors: synthesis, |
| Related PDB | 1hvh |
| Related UniProtKB | |
| [62] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 9521105 |
| Journal | Protein Sci |
| Year | 1998 |
| Volume | 7 |
| Pages | 300-5 |
| Authors | Hong L, Hartsuck JA, Foundling S, Ermolieff J, Tang J |
| Title |
Active-site mobility in human immunodeficiency virus, |
| Related PDB | 1axa |
| Related UniProtKB | |
| [63] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 57-155. |
| Medline ID | 99043699 |
| PubMed ID | 9827997 |
| Journal | Protein Sci |
| Year | 1998 |
| Volume | 7 |
| Pages | 2314-23 |
| Authors | Kervinen J, Lubkowski J, Zdanov A, Bhatt D, Dunn BM, Hui KY, Powell DJ, Kay J, Wlodawer A, Gustchina A |
| Title |
Toward a universal inhibitor of retroviral proteases: comparative analysis of the interactions of LP-130 complexed with proteases from HIV-1, |
| Related PDB | 1ody |
| Related UniProtKB | P04585 |
| [64] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9672038 |
| Journal | Proteins |
| Year | 1998 |
| Volume | 32 |
| Pages | 7-16 |
| Authors | Rick SW, Erickson JW, Burt SK |
| Title | Reaction path and free energy calculations of the transition between alternate conformations of HIV-1 protease. |
| Related PDB | |
| Related UniProtKB | |
| [65] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 10429209 |
| Journal | Eur J Biochem |
| Year | 1999 |
| Volume | 263 |
| Pages | 238-45 |
| Authors | Mahalingam B, Louis JM, Reed CC, Adomat JM, Krouse J, Wang YF, Harrison RW, Weber IT |
| Title | Structural and kinetic analysis of drug resistant mutants of HIV-1 protease. |
| Related PDB | 1dw6 1ebk |
| Related UniProtKB | |
| [66] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10438521 |
| Journal | J Biol Chem |
| Year | 1999 |
| Volume | 274 |
| Pages | 23437-42 |
| Authors | Louis JM, Wondrak EM, Kimmel AR, Wingfield PT, Nashed NT |
| Title |
Proteolytic processing of HIV-1 protease precursor, |
| Related PDB | |
| Related UniProtKB | |
| [67] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11000004 |
| Journal | J Med Chem |
| Year | 2000 |
| Volume | 43 |
| Pages | 3495-504 |
| Authors | Tyndall JD, Reid RC, Tyssen DP, Jardine DK, Todd B, Passmore M, March DR, Pattenden LK, Bergman DA, Alewood D, Hu SH, Alewood PF, Birch CJ, Martin JL, Fairlie DP |
| Title |
Synthesis, |
| Related PDB | |
| Related UniProtKB | |
| [68] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 10651036 |
| Journal | Proteins |
| Year | 2000 |
| Volume | 38 |
| Pages | 29-40 |
| Authors | Li M, Morris GM, Lee T, Laco GS, Wong CH, Olson AJ, Elder JH, Wlodawer A, Gustchina A |
| Title | Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease. |
| Related PDB | 3tlh |
| Related UniProtKB | |
| [69] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10858137 |
| Journal | Science |
| Year | 2000 |
| Volume | 288 |
| Pages | 1590 |
| Authors | Kent S, Marshall GR, Wlodawer A |
| Title | Determining the 3D structure of HIV-1 protease. |
| Related PDB | |
| Related UniProtKB | |
| [70] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11741592 |
| Journal | FEBS Lett |
| Year | 2001 |
| Volume | 509 |
| Pages | 218-24 |
| Authors | Bhavesh NS, Panchal SC, Mittal R, Hosur RV |
| Title | NMR identification of local structural preferences in HIV-1 protease tethered heterodimer in 6 M guanidine hydrochloride. |
| Related PDB | |
| Related UniProtKB | |
| [71] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 11170625 |
| Journal | J Med Chem |
| Year | 2001 |
| Volume | 44 |
| Pages | 155-69 |
| Authors | Schaal W, Karlsson A, Ahlsen G, Lindberg J, Andersson HO, Danielson UH, Classon B, Unge T, Samuelsson B, Hulten J, Hallberg A, Karlen A |
| Title | Synthesis and comparative molecular field analysis (CoMFA) of symmetric and nonsymmetric cyclic sulfamide HIV-1 protease inhibitors. |
| Related PDB | 1g2k |
| Related UniProtKB | |
| [72] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11410934 |
| Journal | Med Res Rev |
| Year | 2001 |
| Volume | 21 |
| Pages | 348-53 |
| Authors | Mager PP |
| Title | The active site of HIV-1 protease. |
| Related PDB | |
| Related UniProtKB | |
| [73] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 11340661 |
| Journal | Proteins |
| Year | 2001 |
| Volume | 43 |
| Pages | 455-64 |
| Authors | Mahalingam B, Louis JM, Hung J, Harrison RW, Weber IT |
| Title | Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes. |
| Related PDB | 1fej 1ff0 1fff 1ffi 1fg6 1fg8 1fgc |
| Related UniProtKB | |
| [74] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 11170214 |
| Journal | Proteins |
| Year | 2001 |
| Volume | 43 |
| Pages | 57-64 |
| Authors | Pillai B, Kannan KK, Hosur MV |
| Title | 1.9 A x-ray study shows closed flap conformation in crystals of tethered HIV-1 PR. |
| Related PDB | 1g6l |
| Related UniProtKB | |
| [75] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11591344 |
| Journal | Structure |
| Year | 2001 |
| Volume | 9 |
| Pages | 887-95 |
| Authors | Rezacova P, Lescar J, Brynda J, Fabry M, Horejsi M, Sedlacek J, Bentley GA |
| Title | Structural basis of HIV-1 and HIV-2 protease inhibition by a monoclonal antibody. |
| Related PDB | |
| Related UniProtKB | |
| [76] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 12051725 |
| Journal | Biochem Biophys Res Commun |
| Year | 2002 |
| Volume | 294 |
| Pages | 395-401 |
| Authors | Kumar M, Kannan KK, Hosur MV, Bhavesh NS, Chatterjee A, Mittal R, Hosur RV |
| Title | Effects of remote mutation on the autolysis of HIV-1 PR: X-ray and NMR investigations. |
| Related PDB | 1lv1 |
| Related UniProtKB | |
| [77] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12034371 |
| Journal | Biochem Pharmacol |
| Year | 2002 |
| Volume | 63 |
| Pages | 1863-73 |
| Authors | Lebon F, Boggetto N, Ledecq M, Durant F, Benatallah Z, Sicsic S, Lapouyade R, Kahn O, Mouithys-Mickalad A, Deby-Dupont G, Reboud-Ravaux M. Metal-organic compounds: a new approach for drug discovery |
| Title | N1-(4-methyl-2-pyridyl)-2,3,6-trimethoxybenzamide copper(II) complex as an inhibitor of human immunodeficiency virus 1 protease. |
| Related PDB | |
| Related UniProtKB | |
| [78] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11802730 |
| Journal | Biochemistry |
| Year | 2002 |
| Volume | 41 |
| Pages | 1302-7 |
| Authors | Porter DJ, Hanlon MH, Furfine ES |
| Title | HIV-1 protease: characterization of a catalytically competent enzyme-substrate intermediate. |
| Related PDB | |
| Related UniProtKB | |
| [79] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12124265 |
| Journal | Biophys J |
| Year | 2002 |
| Volume | 83 |
| Pages | 794-807 |
| Authors | Trylska J, Bala P, Geller M, Grochowski P |
| Title | Molecular dynamics simulations of the first steps of the reaction catalyzed by HIV-1 protease. |
| Related PDB | |
| Related UniProtKB | |
| [80] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11906284 |
| Journal | J Med Chem |
| Year | 2002 |
| Volume | 45 |
| Pages | 1432-8 |
| Authors | Dohnalek J, Hasek J, Duskova J, Petrokova H, Hradilek M, Soucek M, Konvalinka J, Brynda J, Sedlacek J, Fabry M |
| Title |
Hydroxyethylamine isostere of an HIV-1 protease inhibitor prefers its amine to the hydroxy group in binding to catalytic aspartates. |
| Related PDB | |
| Related UniProtKB | |
| [81] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12051929 |
| Journal | J Mol Biol |
| Year | 2002 |
| Volume | 319 |
| Pages | 567-83 |
| Authors | Piana S, Carloni P, Parrinello M |
| Title | Role of conformational fluctuations in the enzymatic reaction of HIV-1 protease. |
| Related PDB | |
| Related UniProtKB | |
| [82] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11771964 |
| Journal | J Mol Biol |
| Year | 2002 |
| Volume | 315 |
| Pages | 21-52 |
| Authors | Zoete V, Michielin O, Karplus M |
| Title | Relation between sequence and structure of HIV-1 protease inhibitor complexes: a model system for the analysis of protein flexibility. |
| Related PDB | |
| Related UniProtKB | |
| [83] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11773409 |
| Journal | J Virol |
| Year | 2002 |
| Volume | 76 |
| Pages | 1349-58 |
| Authors | Yoshimura K, Kato R, Kavlick MF, Nguyen A, Maroun V, Maeda K, Hussain KA, Ghosh AK, Gulnik SV, Erickson JW, Mitsuya H |
| Title |
A potent human immunodeficiency virus type 1 protease inhibitor, |
| Related PDB | |
| Related UniProtKB | |
| [84] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 11790852 |
| Journal | Protein Sci |
| Year | 2002 |
| Volume | 11 |
| Pages | 418-29 |
| Authors | King NM, Melnick L, Prabu-Jeyabalan M, Nalivaika EA, Yang SS, Gao Y, Nie X, Zepp C, Heefner DL, Schiffer CA |
| Title | Lack of synergy for inhibitors targeting a multi-drug-resistant HIV-1 protease. |
| Related PDB | 1k6c 1k6p 1k6t 1k6v |
| Related UniProtKB | |
| [85] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12237461 |
| Journal | Protein Sci |
| Year | 2002 |
| Volume | 11 |
| Pages | 2393-402 |
| Authors | Piana S, Carloni P, Rothlisberger U |
| Title | Drug resistance in HIV-1 protease: Flexibility-assisted mechanism of compensatory mutations. |
| Related PDB | |
| Related UniProtKB | |
| [86] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 12012342 |
| Journal | Proteins |
| Year | 2002 |
| Volume | 48 |
| Pages | 107-16 |
| Authors | Mahalingam B, Boross P, Wang YF, Louis JM, Fischer CC, Tozser J, Harrison RW, Weber IT |
| Title | Combining mutations in HIV-1 protease to understand mechanisms of resistance. |
| Related PDB | 1k1t 1k1u 1k2b 1k2c |
| Related UniProtKB | |
| [87] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12005435 |
| Journal | Structure |
| Year | 2002 |
| Volume | 10 |
| Pages | 369-81 |
| Authors | Prabu-Jeyabalan M, Nalivaika E, Schiffer CA |
| Title | Substrate shape determines specificity of recognition for HIV-1 protease: analysis of crystal structures of six substrate complexes. |
| Related PDB | |
| Related UniProtKB | |
| [88] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12534275 |
| Journal | Biochemistry |
| Year | 2003 |
| Volume | 42 |
| Pages | 631-8 |
| Authors | Muzammil S, Ross P, Freire E |
| Title | A major role for a set of non-active site mutations in the development of HIV-1 protease drug resistance. |
| Related PDB | |
| Related UniProtKB | |
| [89] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12564936 |
| Journal | Biochemistry |
| Year | 2003 |
| Volume | 42 |
| Pages | 1326-33 |
| Authors | Zhu Z, Schuster DI, Tuckerman ME |
| Title | Molecular dynamics study of the connection between flap closing and binding of fullerene-based inhibitors of the HIV-1 protease. |
| Related PDB | |
| Related UniProtKB | |
| [90] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12675950 |
| Journal | BMC Struct Biol |
| Year | 2003 |
| Volume | 3 |
| Pages | 2 |
| Authors | Jenwitheesuk E, Samudrala R |
| Title | Improved prediction of HIV-1 protease-inhibitor binding energies by molecular dynamics simulations. |
| Related PDB | |
| Related UniProtKB | |
| [91] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12644464 |
| Journal | J Biol Chem |
| Year | 2003 |
| Volume | 278 |
| Pages | 19980-5 |
| Authors | Bhavesh NS, Sinha R, Mohan PM, Hosur RV |
| Title | NMR elucidation of early folding hierarchy in HIV-1 protease. |
| Related PDB | |
| Related UniProtKB | |
| [92] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12933791 |
| Journal | J Biol Chem |
| Year | 2003 |
| Volume | 278 |
| Pages | 43311-9 |
| Authors | Ishima R, Torchia DA, Lynch SM, Gronenborn AM, Louis JM |
| Title | Solution structure of the mature HIV-1 protease monomer: insight into the tertiary fold and stability of a precursor. |
| Related PDB | |
| Related UniProtKB | |
| [93] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12696052 |
| Journal | Proteins |
| Year | 2003 |
| Volume | 51 |
| Pages | 409-22 |
| Authors | Kurt N, Scott WR, Schiffer CA, Haliloglu T |
| Title | Cooperative fluctuations of unliganded and substrate-bound HIV-1 protease: a structure-based analysis on a variety of conformations from crystallography and molecular dynamics simulations. |
| Related PDB | |
| Related UniProtKB | |
| [94] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 15317462 |
| Journal | J Med Chem |
| Year | 2004 |
| Volume | 47 |
| Pages | 4507-16 |
| Authors | Fornabaio M, Spyrakis F, Mozzarelli A, Cozzini P, Abraham DJ, Kellogg GE |
| Title |
Simple, |
| Related PDB | |
| Related UniProtKB | |
| [95] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 15184023 |
| Journal | J Mol Biol |
| Year | 2004 |
| Volume | 340 |
| Pages | 67-79 |
| Authors | Levy Y, Caflisch A, Onuchic JN, Wolynes PG |
| Title | The folding and dimerization of HIV-1 protease: evidence for a stable monomer from simulations. |
| Related PDB | |
| Related UniProtKB | |
| [96] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 15066436 |
| Journal | J Mol Biol |
| Year | 2004 |
| Volume | 338 |
| Pages | 341-52 |
| Authors | Tie Y, Boross PI, Wang YF, Gaddis L, Hussain AK, Leshchenko S, Ghosh AK, Louis JM, Harrison RW, Weber IT |
| Title | High resolution crystal structures of HIV-1 protease with a potent non-peptide inhibitor (UIC-94017) active against multi-drug-resistant clinical strains. |
| Related PDB | |
| Related UniProtKB | |
| [97] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 14990731 |
| Journal | J Virol |
| Year | 2004 |
| Volume | 78 |
| Pages | 3123-32 |
| Authors | Logsdon BC, Vickrey JF, Martin P, Proteasa G, Koepke JI, Terlecky SR, Wawrzak Z, Winters MA, Merigan TC, Kovari LC |
| Title | Crystal structures of a multidrug-resistant human immunodeficiency virus type 1 protease reveal an expanded active-site cavity. |
| Related PDB | |
| Related UniProtKB | |
| [98] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 15289598 |
| Journal | Proc Natl Acad Sci U S A |
| Year | 2004 |
| Volume | 101 |
| Pages | 11640-5 |
| Authors | Fernandez A, Rogale K, Scott R, Scheraga HA |
| Title | Inhibitor design by wrapping packing defects in HIV-1 proteins. |
| Related PDB | |
| Related UniProtKB | |
| [99] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 15044738 |
| Journal | Protein Sci |
| Year | 2004 |
| Volume | 13 |
| Pages | 1108-23 |
| Authors | Perryman AL, Lin JH, McCammon JA |
| Title | HIV-1 protease molecular dynamics of a wild-type and of the V82F/I84V mutant: possible contributions to drug resistance and a potential new target site for drugs. |
| Related PDB | |
| Related UniProtKB | |
| [100] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 14739332 |
| Journal | Protein Sci |
| Year | 2004 |
| Volume | 13 |
| Pages | 513-28 |
| Authors | Trylska J, Grochowski P, McCammon JA |
| Title | The role of hydrogen bonding in the enzymatic reaction catalyzed by HIV-1 protease. |
| Related PDB | |
| Related UniProtKB | |
| Comments |
|---|
|
The protein, This entry corresponds to the protease domain, According to the literature, |
| Created | Updated |
|---|---|
| 2004-03-05 | 2012-07-03 |