RLCP 1.30.35890.994 :EzCatDB EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms


R 1.-.-.- : Hydrolysis (bond cleavage by water) (Reaction)

L 1.30.-.- : C-O bond (O-glycoside bond) (Ligand group involved)

C 1.30.35890.- : alpha-N-acetylgalactosaminidase-like mechanism (Nucleophile/Acid-Base/Stabilizer/Modulator); Modulation of nucleophile and acid-base; Acid protonation to leaving group leading to transition-state (SN1-like); Stabilization of transition-state; Nucleohilic attack forming intermediate; Base deprotonation of water; Activated water attack on intermediate completing reaction (Catalytic mechanism)

P 1.30.35890.994 : Three acidic residues + Arg/Tyr (Residues/cofactors in Protein)

1st Nucleophile : a catalytic residue
Catalytic groups : groups in residue/substrate
General Base : a catalytic residue
General Acid : a catalytic residue

Related Enzymes

There are 3 entries in this class.
  • D00664 : 3.2.1.22; Alpha-galactosidase (Catalytic domain; 3.20.20.70)
  • D00665 : 3.2.1.49; Alpha-N-acetylgalactosaminidase (Catalytic domain; 3.20.20.70)
  • D00863 : 3.2.1.22; Alpha-galactosidase (Catalytic domain; 3.20.20.70)
    • Copyright: Nozomi Nagano, JST & CBRC-AIST
    Funded by PRESTO/Japan Science and Technology Agency (JST) (December 2001 - November 2004)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
    Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (September 2005 - September 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (October 2007 - September 2010)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2012 - March 2013)
    Supported by the commission for the Development of Artificial Gene Synthesis Technology for Creating Innovative Biomaterial from the Ministry of Economy, Trade and Industry (METI) (October 2012 - March 2016)
    Funded by the project commissioned by the New Energy and Industrial Technology Development Organization (NEDO) (April 2016 -)