DB code: T00074

RLCP classification 1.13.30000.10 : Hydrolysis
CATH domain 4.10.140.10 : Epsilon-Thrombin; Chain L
2.40.10.10 : Thrombin, subunit H Catalytic domain
2.40.10.10 : Thrombin, subunit H Catalytic domain
E.C. 3.4.21.5
CSA
M-CSA
MACiE

CATH domain Related DB codes (homologues)
2.40.10.10 : Thrombin, subunit H M00139 D00214 M00167 D00426 M00133 D00428 D00429 D00430 D00431 D00432 D00433 D00434 D00435 M00227 M00209 D00194 D00197 D00211 D00212 D00216 M00212 D00224 D00497 M00217 M00216 D00528 D00848 D00850 D00851 D00852 D00855 M00152 M00155 M00157 M00181 M00315 M00316 M00317 M00348 M00349 T00410 T00411

Uniprot Enzyme Name
UniprotKB Protein name Synonyms Contains RefSeq MEROPS Pfam
P00734 Prothrombin
EC 3.4.21.5
Coagulation factor II
Activation peptide fragment 1
Activation peptide fragment 2
Thrombin light chain
Thrombin heavy chain
NP_000497.1 (Protein)
NM_000506.3 (DNA/RNA sequence)
S01.217 (Serine)
PF00594 (Gla)
PF00051 (Kringle)
PF09396 (Thrombin_light)
PF00089 (Trypsin)
[Graphical View]
P00735 Prothrombin
EC 3.4.21.5
Coagulation factor II
Activation peptide fragment 1
Activation peptide fragment 2
Thrombin light chain
Thrombin heavy chain
NP_776302.1 (Protein)
NM_173877.1 (DNA/RNA sequence)
S01.217 (Serine)
PF00594 (Gla)
PF00051 (Kringle)
PF09396 (Thrombin_light)
PF00089 (Trypsin)
[Graphical View]

KEGG enzyme name
thrombin
fibrinogenase
thrombase
thrombofort
topical
thrombin-C
tropostasin
activated blood-coagulation factor II
blood-coagulation factor IIa
factor IIa
E thrombin
beta-thrombin
gamma-thrombin

UniprotKB: Accession Number Entry name Activity Subunit Subcellular location Cofactor
P00734 THRB_HUMAN Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B. Secreted, extracellular space.
P00735 THRB_BOVIN Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B. Secreted, extracellular space.

KEGG Pathways
Map code Pathways E.C.

Compound table
Substrates Products Intermediates
KEGG-id C00012 C00393 C00001 C00290 C00952 C02404
E.C.
Compound Peptide Fibrinogen H2O Fibrin Fibrinopeptide A Fibrinopeptide B
Type peptide/protein peptide/protein H2O amine group,peptide/protein peptide/protein peptide/protein
ChEBI 15377
15377
5054
5054
PubChem 22247451
962
22247451
962
439199
439199
1a2cL Unbound Unbound Unbound Unbound Unbound Unbound
1a3bL Unbound Unbound Unbound Unbound Unbound Unbound
1a3eL Unbound Unbound Unbound Unbound Unbound Unbound
1a46L Unbound Unbound Unbound Unbound Unbound Unbound
1a4wL Unbound Unbound Unbound Unbound Unbound Unbound
1a5gL Unbound Unbound Unbound Unbound Unbound Unbound
1a61L Unbound Unbound Unbound Unbound Unbound Unbound
1abiL Unbound Unbound Unbound Unbound Unbound Unbound
1abjL Unbound Unbound Unbound Unbound Unbound Unbound
1ad8L Unbound Unbound Unbound Unbound Unbound Unbound
1ae8L Unbound Unbound Unbound Unbound Unbound Unbound
1afeL Unbound Unbound Unbound Unbound Unbound Unbound
1ahtL Unbound Unbound Unbound Unbound Unbound Unbound
1ai8L Unbound Unbound Unbound Unbound Unbound Unbound
1aixL Unbound Unbound Unbound Unbound Unbound Unbound
1avgL Unbound Unbound Unbound Unbound Unbound Unbound
1awfL Unbound Unbound Unbound Unbound Unbound Unbound
1awhA Unbound Unbound Unbound Unbound Unbound Unbound
1awhB Unbound Unbound Unbound Unbound Unbound Unbound
1ay6L Unbound Unbound Unbound Unbound Unbound Unbound
1b5gL Unbound Unbound Unbound Unbound Unbound Unbound
1b7xA Unbound Unbound Unbound Unbound Unbound Unbound
1ba8A Unbound Unbound Unbound Unbound Unbound Unbound
1bb0A Unbound Unbound Unbound Unbound Unbound Unbound
1bbrJ Unbound Unbound Unbound Unbound Unbound Unbound
1bbrL Unbound Unbound Unbound Unbound Unbound Unbound
1bbrM Unbound Unbound Unbound Unbound Unbound Unbound
1bcuL Unbound Unbound Unbound Unbound Unbound Unbound
1bhxA Unbound Unbound Unbound Unbound Unbound Unbound
1bmmL Unbound Unbound Unbound Unbound Unbound Unbound
1bmnL Unbound Unbound Unbound Unbound Unbound Unbound
1bthL Unbound Unbound Unbound Unbound Unbound Unbound
1bthJ Unbound Unbound Unbound Unbound Unbound Unbound
1c1uL Unbound Unbound Unbound Unbound Unbound Unbound
1c1vL Unbound Unbound Unbound Unbound Unbound Unbound
1c1wL Unbound Unbound Unbound Unbound Unbound Unbound
1c4u1 Unbound Unbound Unbound Unbound Unbound Unbound
1c4v1 Unbound Unbound Unbound Unbound Unbound Unbound
1c4y1 Unbound Unbound Unbound Unbound Unbound Unbound
1c5lL Unbound Unbound Unbound Unbound Unbound Unbound
1c5nL Unbound Unbound Unbound Unbound Unbound Unbound
1c5oL Unbound Unbound Unbound Unbound Unbound Unbound
1ca8A Unbound Unbound Unbound Unbound Unbound Unbound
1d3dA Unbound Unbound Unbound Unbound Unbound Unbound
1d3pA Unbound Unbound Unbound Unbound Unbound Unbound
1d3qA Unbound Unbound Unbound Unbound Unbound Unbound
1d3tA Unbound Unbound Unbound Unbound Unbound Unbound
1d4pA Unbound Unbound Unbound Unbound Unbound Unbound
1de7L Unbound Unbound Unbound Unbound Unbound Unbound
1de7K Unbound Unbound Unbound Unbound Unbound Unbound
1ditL Unbound Unbound Unbound Unbound Unbound Unbound
1dwcL Unbound Unbound Unbound Unbound Unbound Unbound
1dwdL Unbound Unbound Unbound Unbound Unbound Unbound
1dweL Unbound Unbound Unbound Unbound Unbound Unbound
1dx5A Unbound Unbound Unbound Unbound Unbound Unbound
1dx5B Unbound Unbound Unbound Unbound Unbound Unbound
1dx5C Unbound Unbound Unbound Unbound Unbound Unbound
1dx5D Unbound Unbound Unbound Unbound Unbound Unbound
1etrL Unbound Unbound Unbound Unbound Unbound Unbound
1etsL Unbound Unbound Unbound Unbound Unbound Unbound
1ettL Unbound Unbound Unbound Unbound Unbound Unbound
1fpcL Unbound Unbound Unbound Unbound Unbound Unbound
1fphL Unbound Unbound Unbound Unbound Unbound Unbound
1h8dL Unbound Unbound Unbound Unbound Unbound Unbound
1h8iL Unbound Unbound Unbound Unbound Unbound Unbound
1hahL Unbound Unbound Unbound Unbound Unbound Unbound
1haiL Unbound Unbound Unbound Unbound Unbound Unbound
1haoL Unbound Unbound Unbound Unbound Unbound Unbound
1hapL Unbound Unbound Unbound Unbound Unbound Unbound
1hbtL Unbound Unbound Unbound Unbound Unbound Unbound
1hdtL Unbound Unbound Unbound Unbound Unbound Unbound
1hgtL Unbound Unbound Unbound Unbound Unbound Unbound
1hltL Unbound Unbound Unbound Unbound Unbound Unbound
1hltJ Unbound Unbound Unbound Unbound Unbound Unbound
1hrtL Unbound Unbound Unbound Unbound Unbound Unbound
1hutL Unbound Unbound Unbound Unbound Unbound Unbound
1hxeL Unbound Unbound Unbound Unbound Unbound Unbound
1hxfL Unbound Unbound Unbound Unbound Unbound Unbound
1ihsL Unbound Unbound Unbound Unbound Unbound Unbound
1ihtL Unbound Unbound Unbound Unbound Unbound Unbound
1lhcL Unbound Unbound Unbound Unbound Unbound Unbound
1lhdL Unbound Unbound Unbound Unbound Unbound Unbound
1lheL Unbound Unbound Unbound Unbound Unbound Unbound
1lhfL Unbound Unbound Unbound Unbound Unbound Unbound
1lhgL Unbound Unbound Unbound Unbound Unbound Unbound
1mkwL Unbound Unbound Unbound Unbound Unbound Unbound
1mkxL Unbound Unbound Unbound Unbound Unbound Unbound
1nrpL Unbound Unbound Unbound Unbound Unbound Unbound
1nrrL Unbound Unbound Unbound Unbound Unbound Unbound
1nrsL Unbound Unbound Unbound Unbound Unbound Unbound
1ppbL Unbound Unbound Unbound Unbound Unbound Unbound
1qbvL Unbound Unbound Unbound Unbound Unbound Unbound
1qhrA Unbound Unbound Unbound Unbound Unbound Unbound
1qj1A Unbound Unbound Unbound Unbound Unbound Unbound
1qj6A Unbound Unbound Unbound Unbound Unbound Unbound
1qj7A Unbound Unbound Unbound Unbound Unbound Unbound
1tbrJ Unbound Unbound Unbound Unbound Unbound Unbound
1tbrL Unbound Unbound Unbound Unbound Unbound Unbound
1tbzL Unbound Unbound Unbound Unbound Unbound Unbound
1thpA Unbound Unbound Unbound Unbound Unbound Unbound
1thrL Unbound Unbound Unbound Unbound Unbound Unbound
1thsL Unbound Unbound Unbound Unbound Unbound Unbound
1tmbL Unbound Unbound Unbound Unbound Unbound Unbound
1tmuL Unbound Unbound Unbound Unbound Unbound Unbound
1tomL Unbound Unbound Unbound Unbound Unbound Unbound
1ucyJ Unbound Unbound Unbound Unbound Unbound Unbound
1ucyL Unbound Unbound Unbound Unbound Unbound Unbound
1ucyM Unbound Unbound Unbound Unbound Unbound Unbound
1umaL Unbound Unbound Unbound Unbound Unbound Unbound
1uvsL Unbound Unbound Unbound Unbound Unbound Unbound
1uvtL Unbound Unbound Unbound Unbound Unbound Unbound
1uvuL Unbound Unbound Unbound Unbound Unbound Unbound
1ycpJ Unbound Unbound Unbound Unbound Unbound Unbound
1ycpL Unbound Unbound Unbound Unbound Unbound Unbound
2hatL Unbound Unbound Unbound Unbound Unbound Unbound
2hgtL Unbound Unbound Unbound Unbound Unbound Unbound
2thfA Unbound Unbound Unbound Unbound Unbound Unbound
3hatL Unbound Unbound Unbound Unbound Unbound Unbound
4htcL Unbound Unbound Unbound Unbound Unbound Unbound
4thnL Unbound Unbound Unbound Unbound Unbound Unbound
5gdsL Unbound Unbound Unbound Unbound Unbound Unbound
7kmeL Unbound Unbound Unbound Unbound Unbound Unbound
8kme1 Unbound Unbound Unbound Unbound Unbound Unbound
1a2cH01 Unbound Unbound Unbound Analogue:ENO-2AC-RPH-OAR(chain R) Unbound Unbound
1a3bH01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:T29
1a3eH01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:T16
1a46H01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:BIC-LYS-OHO(chain R)
1a4wH01 Analogue:ANS-ARG-2EP-KTH(chain R) Unbound Unbound Unbound Unbound Unbound
1a5gH01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:BIC-ARG-EOA(chain R)
1a61H01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:BIC-ARG-LOM(chain R)
1abiH01 Analogue:HMR_3-GLY_4(chain I) Unbound Unbound Unbound Unbound Unbound
1abjH01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:PHE-PRO-ARG-CH2(chain I)
1ad8H01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:MDL
1ae8H01 Analogue:AZL Unbound Unbound Unbound Unbound Unbound
1afeH01 Analogue:ALZ Unbound Unbound Unbound Unbound Unbound
1ahtH01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:APA
1ai8H01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:T42
1aixH01 Analogue:T19 Unbound Unbound Unbound Unbound Unbound
1avgH01 Unbound Unbound Unbound Unbound Unbound Unbound
1awfH01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:GR4
1awhB01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:GR3
1awhD01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:GR3
1ay6H01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:HMF-PRO-ARG-HHO(chain I)
1b5gH01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:BCC-ARG-THZ(chain I)
1b7xB01 Unbound Unbound Unbound Unbound Unbound Intermediate-bound:PHE-PRO-ARG(chain C)
1ba8B01 Unbound Unbound Unbound Unbound Unbound Intermediate-bound:PMS-NVA-GLY-ARG(chain D)
1bb0B01 Analogue:PMS-NVA-GLY-3GA(chain D) Unbound Unbound Unbound Unbound Unbound
1bbrE Unbound Unbound Unbound Bound:ARG_318(chain F) Unbound Unbound
1bbrK01 Unbound Unbound Unbound Bound:ARG_318(chain G) Unbound Unbound
1bbrN01 Unbound Unbound Unbound Bound:ARG_318(chain I) Unbound Unbound
1bcuH01 Unbound Unbound Unbound Unbound Unbound Unbound
1bhxF Analogue:R56 Unbound Unbound Unbound Unbound Unbound
1bmmH01 Analogue:BM2 Unbound Unbound Unbound Unbound Unbound
1bmnH01 Analogue:BM9 Unbound Unbound Unbound Unbound Unbound
1bthH01 Analogue:LYS_15-ALA_16(chain P) Unbound Unbound Unbound Unbound Unbound
1bthK01 Analogue:LYS_15-ALA_16(chain Q) Unbound Unbound Unbound Unbound Unbound
1c1uH01 Analogue:BAI Unbound Unbound Unbound Unbound Unbound
1c1vH01 Analogue:BAB Unbound Unbound Unbound Unbound Unbound
1c1wH01 Analogue:BAH Unbound Unbound Unbound Unbound Unbound
1c4u201 Analogue:IH1 Unbound Unbound Unbound Unbound Unbound
1c4v201 Analogue:IH2 Unbound Unbound Unbound Unbound Unbound
1c4y201 Analogue:IH3 Unbound Unbound Unbound Unbound Unbound
1c5lH01 Unbound Unbound Unbound Unbound Unbound Unbound
1c5nH01 Unbound Unbound Unbound Unbound Unbound Unbound
1c5oH01 Unbound Unbound Unbound Unbound Unbound Unbound
1ca8B01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:PMS-NVA-GLY-3GA(chain D)
1d3dB01 Analogue:BZT Unbound Unbound Unbound Unbound Unbound
1d3pB01 Analogue:BT3 Unbound Unbound Unbound Unbound Unbound
1d3qB01 Analogue:BT2 Unbound Unbound Unbound Unbound Unbound
1d3tB01 Analogue:BT1 Unbound Unbound Unbound Unbound Unbound
1d4pB01 Analogue:BPP Unbound Unbound Unbound Unbound Unbound
1d6wA01 Analogue:AIM-HMM-SML Unbound Unbound Unbound Unbound Unbound
1d9iA01 Analogue:CHN-HMM-SML Unbound Unbound Unbound Unbound Unbound
1de7H01 Unbound Unbound Unbound Unbound Unbound Intermediate-bound:PRO_36-ARG_37(chain A)
1de7K01 Unbound Unbound Unbound Unbound Unbound Intermediate-bound:THR-VAL-GLU-LEU-GLN-GLY-VAL-VAL-PRO-ARG(chain B)
1ditH01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:ARG_4-FMT_5(chain P)
1dojA01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:CH3-DPN-PRO-AR2(chain I)
1dwcH01 Unbound Unbound Unbound Analogue:MIT Unbound Unbound
1dwdH01 Analogue:MID Unbound Unbound Unbound Unbound Unbound
1dweH01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:PHE-PRO-ARG-CH2(chain P)
1dx5M01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:GLU-GLY-ARM(chain E)
1dx5N01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:GLU-GLY-ARM(chain F)
1dx5O01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:GLU-GLY-ARM(chain G)
1dx5P01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:GLU-GLY-ARM(chain H)
1eojA01 Analogue:CPI_3-TIH_4(chain B) Unbound Unbound Unbound Unbound Unbound
1eolA01 Analogue:CPI_3-NLE_4(chain B) Unbound Unbound Unbound Unbound Unbound
1etrH01 Unbound Unbound Unbound Analogue:MQI-ARG-MCP(chain M) Unbound Unbound
1etsH01 Analogue:NAS-GLY-APH-PIP(chain N) Unbound Unbound Unbound Unbound Unbound
1ettH01 Analogue:TOS-APH-PIP(chain T) Unbound Unbound Unbound Unbound Unbound
1fpcH01 Analogue:ANS-ARG-EPI(chain R) Unbound Unbound Unbound Unbound Unbound
1fphH01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:ARG_16-CH2_17(chain F)
1h8dH01 Unbound Unbound Unbound Analogue:PHW Unbound Unbound
1h8iH01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:PHW
1hagE01 Unbound Unbound Unbound Unbound Unbound Unbound
1hahH01 Unbound Unbound Unbound Unbound Unbound Unbound
1haiH01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:PHE-PRO-ARG-CH2(chain I)
1haoH01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:PHE-PRO-ARG-CH2(chain P)
1hapH01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:PHE-PRO-ARG-CH2(chain P)
1hbtH01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:ARG_3-PAA_3(chain I)
1hdtH01 Analogue:ALG-PHE-ALO-PHE-CH3(chain I) Unbound Unbound Unbound Unbound Unbound
1hgtH01 Unbound Unbound Unbound Unbound Unbound Unbound
1hltH01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:PHE-PRO-ARG-CH2(chain I)
1hltK01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:PHE-PRO-ARG-CH2(chain M)
1hrtH01 Unbound Unbound Unbound Unbound Unbound Unbound
1hutH01 Unbound Unbound Unbound Analogue:PHE-PRO-ARG-CH2(chain I) Unbound Unbound
1hxeH01 Unbound Unbound Unbound Unbound Unbound Unbound
1hxfH01 Unbound Unbound Unbound Unbound Unbound Unbound
1ihsH01 Analogue:ARG_3-CBG_3(chain I) Unbound Unbound Unbound Unbound Unbound
1ihtH01 Analogue:ARG_3-PTL_3(chain I) Unbound Unbound Unbound Unbound Unbound
1lhcH01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:DP7
1lhdH01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:DI2
1lheH01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:DI3
1lhfH01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:DI4
1lhgH01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:DI5
1mkwH01 Unbound Unbound Unbound Unbound Unbound Unbound
1mkwK01 Unbound Unbound Unbound Unbound Unbound Unbound
1mkxH01 Unbound Unbound Unbound Unbound Unbound Unbound
1mkxK01 Unbound Unbound Unbound Unbound Unbound Unbound
1nrpH01 Analogue:LEU-ASP-PRO-HMR-SER Unbound Unbound Unbound Unbound Unbound
1nrrH01 Unbound Unbound Unbound Analogue:PHE-PRO-ARG-CH2(chain P) Unbound Unbound
1nrsH01 Unbound Unbound Unbound Bound:LEU-ASP-PRO-ARG(chain R) Unbound Unbound
1ppbH01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:PHE-PRO-ARG-CH2(chain I)
1qbvH01 Analogue:PPX Unbound Unbound Unbound Unbound Unbound
1qhrB01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:157
1qj1B01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:166
1qj6B01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:167
1qj7B01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:GR1
1tbrH01 Analogue:HIS_10-ALA_11(chain R) Unbound Unbound Unbound Unbound Unbound
1tbrK01 Analogue:HIS_10-ALA_11(chain S) Unbound Unbound Unbound Unbound Unbound
1tbzH01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:DPN-PRO-ARG-THZ(chain R)
1thpB01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:PHE-PRO-ARG-CH2(chain C)
1thrH01 Unbound Unbound Unbound Unbound Unbound Unbound
1thsH01 Unbound Unbound Unbound Unbound Unbound Unbound
1tmbH01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:FOR-ALA-PRO-ARG-FOR-PHE-AHT(chain T)
1tmtH01 Unbound Unbound Unbound Bound:PHE-PRO-ARG(chain I) Unbound Unbound
1tmuH01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:PHE-PRO-ARG-CH2(chain I)
1tomH01 Analogue:MIN Unbound Unbound Unbound Unbound Unbound
1ucyE Analogue:OPR_16(chain F) Unbound Unbound Unbound Unbound Unbound
1ucyK01 Analogue:OPR_16(chain G) Unbound Unbound Unbound Unbound Unbound
1ucyN01 Analogue:OPR_16(chain I) Unbound Unbound Unbound Unbound Unbound
1umaH01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:IN2
1uvsH01 Analogue:I11 Unbound Unbound Unbound Unbound Unbound
1uvtH01 Analogue:I48 Unbound Unbound Unbound Unbound Unbound
1uvuH01 Unbound Unbound Unbound Unbound Unbound Unbound
1ycpH01 Bound:GLY-VAL-ARG-GLY-PRO(chain F) Unbound Unbound Unbound Unbound Unbound
1ycpM Bound:GLY-VAL-ARG-GLY-PRO(chain N) Unbound Unbound Unbound Unbound Unbound
2hatH01 Unbound Unbound Unbound Analogue:MBN-ABN-RNG-GLY-VAL-ARG-CH3(chain T) Unbound Unbound
2hgtH01 Unbound Unbound Unbound Bound:PHE-PRO-ARG(chain I) Unbound Unbound
2thfB01 Unbound Unbound Unbound Unbound Unbound Intermediate-analogue:PHE-PRO-ARG-CH2(chain C)
3hatH01 Unbound Unbound Unbound Bound:RNG-GLY-VAL-ARG(chain T) Unbound Unbound
4htcH01 Unbound Unbound Unbound Unbound Unbound Unbound
4thnH01 Unbound Unbound Unbound Unbound Unbound Unbound
5gdsH01 Unbound Unbound Unbound Unbound Unbound Unbound
7kmeH01 Unbound Unbound Unbound Unbound Unbound Unbound
8kme201 Unbound Unbound Unbound Unbound Unbound Unbound
1a2cH02 Unbound Unbound Unbound Unbound Unbound Unbound
1a3bH02 Unbound Unbound Unbound Unbound Unbound Unbound
1a3eH02 Unbound Unbound Unbound Unbound Unbound Unbound
1a46H02 Unbound Unbound Unbound Unbound Unbound Unbound
1a4wH02 Unbound Unbound Unbound Unbound Unbound Unbound
1a5gH02 Unbound Unbound Unbound Unbound Unbound Unbound
1a61H02 Unbound Unbound Unbound Unbound Unbound Unbound
1abiH02 Unbound Unbound Unbound Unbound Unbound Unbound
1abjH02 Unbound Unbound Unbound Unbound Unbound Unbound
1ad8H02 Unbound Unbound Unbound Unbound Unbound Unbound
1ae8H02 Unbound Unbound Unbound Unbound Unbound Unbound
1afeH02 Unbound Unbound Unbound Unbound Unbound Unbound
1ahtH02 Unbound Unbound Unbound Unbound Unbound Unbound
1ai8H02 Unbound Unbound Unbound Unbound Unbound Unbound
1aixH02 Unbound Unbound Unbound Unbound Unbound Unbound
1avgH02 Unbound Unbound Unbound Unbound Unbound Unbound
1awfH02 Unbound Unbound Unbound Unbound Unbound Unbound
1awhB02 Unbound Unbound Unbound Unbound Unbound Unbound
1awhD02 Unbound Unbound Unbound Unbound Unbound Unbound
1ay6H02 Unbound Unbound Unbound Unbound Unbound Unbound
1b5gH02 Unbound Unbound Unbound Unbound Unbound Unbound
1b7xB02 Unbound Unbound Unbound Unbound Unbound Unbound
1ba8B02 Unbound Unbound Unbound Unbound Unbound Unbound
1bb0B02 Unbound Unbound Unbound Unbound Unbound Unbound
1bbrH Unbound Unbound Unbound Unbound Unbound Unbound
1bbrK02 Unbound Unbound Unbound Unbound Unbound Unbound
1bbrN02 Unbound Unbound Unbound Unbound Unbound Unbound
1bcuH02 Unbound Unbound Unbound Unbound Unbound Unbound
1bhxB Unbound Unbound Unbound Unbound Unbound Unbound
1bmmH02 Unbound Unbound Unbound Unbound Unbound Unbound
1bmnH02 Unbound Unbound Unbound Unbound Unbound Unbound
1bthH02 Unbound Unbound Unbound Unbound Unbound Unbound
1bthK02 Unbound Unbound Unbound Unbound Unbound Unbound
1c1uH02 Unbound Unbound Unbound Unbound Unbound Unbound
1c1vH02 Unbound Unbound Unbound Unbound Unbound Unbound
1c1wH02 Unbound Unbound Unbound Unbound Unbound Unbound
1c4u202 Unbound Unbound Unbound Unbound Unbound Unbound
1c4v202 Unbound Unbound Unbound Unbound Unbound Unbound
1c4y202 Unbound Unbound Unbound Unbound Unbound Unbound
1c5lH02 Unbound Unbound Unbound Unbound Unbound Unbound
1c5nH02 Unbound Unbound Unbound Unbound Unbound Unbound
1c5oH02 Unbound Unbound Unbound Unbound Unbound Unbound
1ca8B02 Unbound Unbound Unbound Unbound Unbound Unbound
1d3dB02 Unbound Unbound Unbound Unbound Unbound Unbound
1d3pB02 Unbound Unbound Unbound Unbound Unbound Unbound
1d3qB02 Unbound Unbound Unbound Unbound Unbound Unbound
1d3tB02 Unbound Unbound Unbound Unbound Unbound Unbound
1d4pB02 Unbound Unbound Unbound Unbound Unbound Unbound
1d6wA02 Unbound Unbound Unbound Unbound Unbound Unbound
1d9iA02 Unbound Unbound Unbound Unbound Unbound Unbound
1de7H02 Unbound Unbound Unbound Unbound Unbound Unbound
1de7K02 Unbound Unbound Unbound Unbound Unbound Unbound
1ditH02 Unbound Unbound Unbound Unbound Unbound Unbound
1dojA02 Unbound Unbound Unbound Unbound Unbound Unbound
1dwcH02 Unbound Unbound Unbound Unbound Unbound Unbound
1dwdH02 Unbound Unbound Unbound Unbound Unbound Unbound
1dweH02 Unbound Unbound Unbound Unbound Unbound Unbound
1dx5M02 Unbound Unbound Unbound Unbound Unbound Unbound
1dx5N02 Unbound Unbound Unbound Unbound Unbound Unbound
1dx5O02 Unbound Unbound Unbound Unbound Unbound Unbound
1dx5P02 Unbound Unbound Unbound Unbound Unbound Unbound
1eojA02 Unbound Unbound Unbound Unbound Unbound Unbound
1eolA02 Unbound Unbound Unbound Unbound Unbound Unbound
1etrH02 Unbound Unbound Unbound Unbound Unbound Unbound
1etsH02 Unbound Unbound Unbound Unbound Unbound Unbound
1ettH02 Unbound Unbound Unbound Unbound Unbound Unbound
1fpcH02 Unbound Unbound Unbound Unbound Unbound Unbound
1fphH02 Unbound Unbound Unbound Unbound Unbound Unbound
1h8dH02 Unbound Unbound Unbound Unbound Unbound Unbound
1h8iH02 Unbound Unbound Unbound Unbound Unbound Unbound
1hagE02 Unbound Unbound Unbound Unbound Unbound Unbound
1hahH02 Unbound Unbound Unbound Unbound Unbound Unbound
1haiH02 Unbound Unbound Unbound Unbound Unbound Unbound
1haoH02 Unbound Unbound Unbound Unbound Unbound Unbound
1hapH02 Unbound Unbound Unbound Unbound Unbound Unbound
1hbtH02 Unbound Unbound Unbound Unbound Unbound Unbound
1hdtH02 Unbound Unbound Unbound Unbound Unbound Unbound
1hgtH02 Unbound Unbound Unbound Unbound Unbound Unbound
1hltH02 Unbound Unbound Unbound Unbound Unbound Unbound
1hltK02 Unbound Unbound Unbound Unbound Unbound Unbound
1hrtH02 Unbound Unbound Unbound Unbound Unbound Unbound
1hutH02 Unbound Unbound Unbound Unbound Unbound Unbound
1hxeH02 Unbound Unbound Unbound Unbound Unbound Unbound
1hxfH02 Unbound Unbound Unbound Unbound Unbound Unbound
1ihsH02 Unbound Unbound Unbound Unbound Unbound Unbound
1ihtH02 Unbound Unbound Unbound Unbound Unbound Unbound
1lhcH02 Unbound Unbound Unbound Unbound Unbound Unbound
1lhdH02 Unbound Unbound Unbound Unbound Unbound Unbound
1lheH02 Unbound Unbound Unbound Unbound Unbound Unbound
1lhfH02 Unbound Unbound Unbound Unbound Unbound Unbound
1lhgH02 Unbound Unbound Unbound Unbound Unbound Unbound
1mkwH02 Unbound Unbound Unbound Unbound Unbound Unbound
1mkwK02 Unbound Unbound Unbound Unbound Unbound Unbound
1mkxH02 Unbound Unbound Unbound Unbound Unbound Unbound
1mkxK02 Unbound Unbound Unbound Unbound Unbound Unbound
1nrpH02 Unbound Unbound Unbound Unbound Unbound Unbound
1nrrH02 Unbound Unbound Unbound Unbound Unbound Unbound
1nrsH02 Unbound Unbound Unbound Unbound Unbound Unbound
1ppbH02 Unbound Unbound Unbound Unbound Unbound Unbound
1qbvH02 Unbound Unbound Unbound Unbound Unbound Unbound
1qhrB02 Unbound Unbound Unbound Unbound Unbound Unbound
1qj1B02 Unbound Unbound Unbound Unbound Unbound Unbound
1qj6B02 Unbound Unbound Unbound Unbound Unbound Unbound
1qj7B02 Unbound Unbound Unbound Unbound Unbound Unbound
1tbrH02 Unbound Unbound Unbound Unbound Unbound Unbound
1tbrK02 Unbound Unbound Unbound Unbound Unbound Unbound
1tbzH02 Unbound Unbound Unbound Unbound Unbound Unbound
1thpB02 Unbound Unbound Unbound Unbound Unbound Unbound
1thrH02 Unbound Unbound Unbound Unbound Unbound Unbound
1thsH02 Unbound Unbound Unbound Unbound Unbound Unbound
1tmbH02 Unbound Unbound Unbound Unbound Unbound Unbound
1tmtH02 Unbound Unbound Unbound Unbound Unbound Unbound
1tmuH02 Unbound Unbound Unbound Unbound Unbound Unbound
1tomH02 Unbound Unbound Unbound Unbound Unbound Unbound
1ucyH Unbound Unbound Unbound Unbound Unbound Unbound
1ucyK02 Unbound Unbound Unbound Unbound Unbound Unbound
1ucyN02 Unbound Unbound Unbound Unbound Unbound Unbound
1umaH02 Unbound Unbound Unbound Unbound Unbound Unbound
1uvsH02 Unbound Unbound Unbound Unbound Unbound Unbound
1uvtH02 Unbound Unbound Unbound Unbound Unbound Unbound
1uvuH02 Unbound Unbound Unbound Unbound Unbound Unbound
1ycpH02 Unbound Unbound Unbound Unbound Unbound Unbound
1ycpK Unbound Unbound Unbound Unbound Unbound Unbound
2hatH02 Unbound Unbound Unbound Unbound Unbound Unbound
2hgtH02 Unbound Unbound Unbound Unbound Unbound Unbound
2thfB02 Unbound Unbound Unbound Unbound Unbound Unbound
3hatH02 Unbound Unbound Unbound Unbound Unbound Unbound
4htcH02 Unbound Unbound Unbound Unbound Unbound Unbound
4thnH02 Unbound Unbound Unbound Unbound Unbound Unbound
5gdsH02 Unbound Unbound Unbound Unbound Unbound Unbound
7kmeH02 Unbound Unbound Unbound Unbound Unbound Unbound
8kme202 Unbound Unbound Unbound Unbound Unbound Unbound

Reference for Active-site residues
resource references E.C.

Active-site residues
PDB Catalytic residues Cofactor-binding residues Modified residues Main-chain involved in catalysis Comment
1a2cL
1a3bL
1a3eL
1a46L
1a4wL
1a5gL
1a61L
1abiL
1abjL
1ad8L
1ae8L
1afeL
1ahtL
1ai8L
1aixL
1avgL
1awfL
1awhA
1awhB
1ay6L
1b5gL
1b7xA
1ba8A
1bb0A
1bbrJ
1bbrL
1bbrM
1bcuL
1bhxA
1bmmL
1bmnL
1bthL
1bthJ
1c1uL
1c1vL
1c1wL
1c4u1
1c4v1
1c4y1
1c5lL
1c5nL
1c5oL
1ca8A
1d3dA
1d3pA
1d3qA
1d3tA
1d4pA
1de7L
1de7K
1ditL
1dwcL
1dwdL
1dweL
1dx5A
1dx5B
1dx5C
1dx5D
1etrL
1etsL
1ettL
1fpcL
1fphL
1h8dL
1h8iL
1hahL
1haiL
1haoL
1hapL
1hbtL
1hdtL
1hgtL
1hltL
1hltJ
1hrtL
1hutL
1hxeL
1hxfL
1ihsL
1ihtL
1lhcL
1lhdL
1lheL
1lhfL
1lhgL
1mkwL
1mkxL
1nrpL
1nrrL
1nrsL
1ppbL
1qbvL
1qhrA
1qj1A
1qj6A
1qj7A
1tbrJ
1tbrL
1tbzL
1thpA
1thrL
1thsL
1tmbL
1tmuL
1tomL
1ucyJ
1ucyL
1ucyM
1umaL
1uvsL
1uvtL
1uvuL
1ycpJ
1ycpL
2hatL
2hgtL
2thfA
3hatL
4htcL
4thnL
5gdsL
7kmeL
8kme1
1a2cH01 SER 195 GLY 193;SER 195
1a3bH01 SER 195 GLY 193;SER 195
1a3eH01 SER 195 GLY 193;SER 195
1a46H01 SER 195 GLY 193;SER 195
1a4wH01 SER 195 GLY 193;SER 195
1a5gH01 SER 195 GLY 193;SER 195
1a61H01 SER 195 GLY 193;SER 195
1abiH01 SER 195 GLY 193;SER 195
1abjH01 SER 195 GLY 193;SER 195
1ad8H01 SER 195 GLY 193;SER 195
1ae8H01 SER 195 GLY 193;SER 195
1afeH01 SER 195 GLY 193;SER 195
1ahtH01 SER 195 GLY 193;SER 195
1ai8H01 SER 195 GLY 193;SER 195
1aixH01 SER 195 GLY 193;SER 195
1avgH01 SER 195 GLY 193;SER 195
1awfH01 SER 195 GLY 193;SER 195
1awhB01 SER 195 GLY 193;SER 195
1awhD01 SER 195 GLY 193;SER 195
1ay6H01 SER 195 GLY 193;SER 195
1b5gH01 SER 195 GLY 193;SER 195
1b7xB01 SER 195 GLY 193;SER 195 mutant Y225I
1ba8B01 SER 195 GLY 193;SER 195
1bb0B01 SER 195 GLY 193;SER 195
1bbrE SER 195 GLY 193;SER 195
1bbrK01 SER 195 GLY 193;SER 195
1bbrN01 SER 195 GLY 193;SER 195
1bcuH01 SER 195 GLY 193;SER 195
1bhxF SER 195 GLY 193;SER 195
1bmmH01 SER 195 GLY 193;SER 195
1bmnH01 SER 195 GLY 193;SER 195
1bthH01 SER 195 GLY 193;SER 195 mutant E192Q
1bthK01 SER 195 GLY 193;SER 195 mutant E192Q
1c1uH01 SER 201 GLY 199;SER 201
1c1vH01 SER 201 GLY 199;SER 201
1c1wH01 SER 201 GLY 199;SER 201
1c4u201 SER 195 GLY 193;SER 195
1c4v201 SER 195 GLY 193;SER 195
1c4y201 SER 195 GLY 193;SER 195
1c5lH01 SER 195 GLY 193;SER 195
1c5nH01 SER 195 GLY 193;SER 195
1c5oH01 SER 195 GLY 193;SER 195
1ca8B01 SER 195 GLY 193;SER 195
1d3dB01 SER 241 GLY 239;SER 241
1d3pB01 SER 241 GLY 239;SER 241
1d3qB01 SER 241 GLY 239;SER 241
1d3tB01 SER 241 GLY 239;SER 241
1d4pB01 SER 241 GLY 239;SER 241
1d6wA01 SER 195 GLY 193;SER 195
1d9iA01 SER 195 GLY 193;SER 195
1de7H01 SER 195 GLY 193;SER 195
1de7K01 SER 195 GLY 193;SER 195
1ditH01 SER 195 GLY 193;SER 195
1dojA01 SER 195 GLY 193;SER 195
1dwcH01 SER 195 GLY 193;SER 195
1dwdH01 SER 195 GLY 193;SER 195
1dweH01 SER 195 GLY 193;SER 195
1dx5M01 SER 195 GLY 193;SER 195
1dx5N01 SER 195 GLY 193;SER 195
1dx5O01 SER 195 GLY 193;SER 195
1dx5P01 SER 195 GLY 193;SER 195
1eojA01 SER 195 GLY 193;SER 195
1eolA01 SER 195 GLY 193;SER 195
1etrH01 SER 195 GLY 193;SER 195
1etsH01 SER 195 GLY 193;SER 195
1ettH01 SER 195 GLY 193;SER 195
1fpcH01 SER 195 GLY 193;SER 195
1fphH01 SER 195 GLY 193;SER 195
1h8dH01 SER 195 GLY 193;SER 195
1h8iH01 SER 195 GLY 193;SER 195
1hagE01 SER 195 GLY 193;SER 195
1hahH01 SER 195 GLY 193;SER 195
1haiH01 SER 195 GLY 193;SER 195
1haoH01 SER 195 GLY 193;SER 195
1hapH01 SER 195 GLY 193;SER 195
1hbtH01 SER 195 GLY 193;SER 195
1hdtH01 SER 195 GLY 193;SER 195
1hgtH01 SER 195 GLY 193;SER 195
1hltH01 SER 195 GLY 193;SER 195
1hltK01 SER 195 GLY 193;SER 195
1hrtH01 SER 195 GLY 193;SER 195
1hutH01 SER 195 GLY 193;SER 195
1hxeH01 SER 195 GLY 193;SER 195
1hxfH01 SER 195 GLY 193;SER 195
1ihsH01 SER 195 GLY 193;SER 195
1ihtH01 SER 195 GLY 193;SER 195
1lhcH01 SER 195 GLY 193;SER 195
1lhdH01 SER 195 GLY 193;SER 195
1lheH01 SER 195 GLY 193;SER 195
1lhfH01 SER 195 GLY 193;SER 195
1lhgH01 SER 195 GLY 193;SER 195
1mkwH01 SER 195 GLY 193;SER 195
1mkwK01 SER 195 GLY 193;SER 195
1mkxH01 SER 195 GLY 193;SER 195
1mkxK01 SER 195 GLY 193;SER 195
1nrpH01 SER 195 GLY 193;SER 195
1nrrH01 SER 195 GLY 193;SER 195
1nrsH01 SER 195 GLY 193;SER 195
1ppbH01 SER 195 GLY 193;SER 195
1qbvH01 SER 195 GLY 193;SER 195
1qhrB01 SER 195 GLY 193;SER 195
1qj1B01 SER 195 GLY 193;SER 195
1qj6B01 SER 195 GLY 193;SER 195
1qj7B01 SER 195 GLY 193;SER 195
1tbrH01 SER 195 GLY 193;SER 195
1tbrK01 SER 195 GLY 193;SER 195
1tbzH01 SER 195 GLY 193;SER 195
1thpB01 SER 195 GLY 193;SER 195 mutant Y225P
1thrH01 SER 195 GLY 193;SER 195
1thsH01 SER 195 GLY 193;SER 195
1tmbH01 SER 195 GLY 193;SER 195
1tmtH01 SER 195 GLY 193;SER 195
1tmuH01 SER 195 GLY 193;SER 195
1tomH01 SER 195 GLY 193;SER 195
1ucyE SER 195 GLY 193;SER 195
1ucyK01 SER 195 GLY 193;SER 195
1ucyN01 SER 195 GLY 193;SER 195
1umaH01 SER 195 GLY 193;SER 195
1uvsH01 SER 195 GLY 193;SER 195
1uvtH01 SER 195 GLY 193;SER 195
1uvuH01 SER 195 GLY 193;SER 195
1ycpH01 SER 195 GLY 193;SER 195
1ycpM SER 195 GLY 193;SER 195
2hatH01 SER 195 GLY 193;SER 195
2hgtH01 SER 195 GLY 193;SER 195
2thfB01 SER 195 GLY 193;SER 195 mutant Y225F
3hatH01 SER 195 GLY 193;SER 195
4htcH01 SER 195 GLY 193;SER 195
4thnH01 SER 195 GLY 193;SER 195
5gdsH01 SER 195 GLY 193;SER 195
7kmeH01 SER 195 GLY 193;SER 195
8kme201 SER 195 GLY 193;SER 195
1a2cH02 HIS 57;ASP 102
1a3bH02 HIS 57;ASP 102
1a3eH02 HIS 57;ASP 102
1a46H02 HIS 57;ASP 102
1a4wH02 HIS 57;ASP 102
1a5gH02 HIS 57;ASP 102
1a61H02 HIS 57;ASP 102
1abiH02 HIS 57;ASP 102
1abjH02 HIS 57;ASP 102
1ad8H02 HIS 57;ASP 102
1ae8H02 HIS 57;ASP 102
1afeH02 HIS 57;ASP 102
1ahtH02 HIS 57;ASP 102
1ai8H02 HIS 57;ASP 102
1aixH02 HIS 57;ASP 102
1avgH02 HIS 57;ASP 102
1awfH02 HIS 57;ASP 102
1awhB02 HIS 57;ASP 102
1awhD02 HIS 57;ASP 102
1ay6H02 HIS 57;