DB code: T00074

RLCP classification	1.13.30000.10 : Hydrolysis
CATH domain	4.10.140.10 : Epsilon-Thrombin; Chain L
	2.40.10.10 : Thrombin, subunit H	Catalytic domain
	2.40.10.10 : Thrombin, subunit H	Catalytic domain
E.C.	3.4.21.5
CSA
M-CSA
MACiE

CATH domain	Related DB codes (homologues)
2.40.10.10 : Thrombin, subunit H	M00139 D00214 M00167 D00426 M00133 D00428 D00429 D00430 D00431 D00432 D00433 D00434 D00435 M00227 M00209 D00194 D00197 D00211 D00212 D00216 M00212 D00224 D00497 M00217 M00216 D00528 D00848 D00850 D00851 D00852 D00855 M00152 M00155 M00157 M00181 M00315 M00316 M00317 M00348 M00349 T00410 T00411

Uniprot Enzyme Name
UniprotKB	Protein name	Synonyms	Contains	RefSeq	MEROPS	Pfam
P00734	Prothrombin	EC 3.4.21.5 Coagulation factor II	Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain	NP_000497.1 (Protein) NM_000506.3 (DNA/RNA sequence)	S01.217 (Serine)	PF00594 (Gla) PF00051 (Kringle) PF09396 (Thrombin_light) PF00089 (Trypsin) [Graphical View]
P00735	Prothrombin	EC 3.4.21.5 Coagulation factor II	Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain	NP_776302.1 (Protein) NM_173877.1 (DNA/RNA sequence)	S01.217 (Serine)	PF00594 (Gla) PF00051 (Kringle) PF09396 (Thrombin_light) PF00089 (Trypsin) [Graphical View]

KEGG enzyme name
thrombin fibrinogenase thrombase thrombofort topical thrombin-C tropostasin activated blood-coagulation factor II blood-coagulation factor IIa factor IIa E thrombin beta-thrombin gamma-thrombin

UniprotKB: Accession Number	Entry name	Activity	Subunit	Subcellular location	Cofactor
P00734	THRB_HUMAN	Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.		Secreted, extracellular space.
P00735	THRB_BOVIN	Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.		Secreted, extracellular space.

KEGG Pathways
Map code	Pathways	E.C.

Compound table
						Substrates			Products			Intermediates
KEGG-id						C00012	C00393	C00001	C00290	C00952	C02404
E.C.
Compound						Peptide	Fibrinogen	H2O	Fibrin	Fibrinopeptide A	Fibrinopeptide B
Type						peptide/protein	peptide/protein	H2O	amine group,peptide/protein	peptide/protein	peptide/protein
ChEBI								15377 15377	5054 5054
PubChem								22247451 962 22247451 962	439199 439199
1a2cL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1a3bL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1a3eL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1a46L						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1a4wL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1a5gL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1a61L						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1abiL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1abjL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ad8L						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ae8L						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1afeL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ahtL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ai8L						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1aixL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1avgL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1awfL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1awhA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1awhB						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ay6L						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1b5gL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1b7xA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ba8A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1bb0A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1bbrJ						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1bbrL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1bbrM						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1bcuL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1bhxA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1bmmL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1bmnL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1bthL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1bthJ						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c1uL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c1vL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c1wL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c4u1						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c4v1						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c4y1						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c5lL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c5nL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c5oL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ca8A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1d3dA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1d3pA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1d3qA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1d3tA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1d4pA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1de7L						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1de7K						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ditL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1dwcL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1dwdL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1dweL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1dx5A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1dx5B						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1dx5C						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1dx5D						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1etrL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1etsL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ettL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1fpcL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1fphL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1h8dL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1h8iL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1hahL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1haiL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1haoL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1hapL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1hbtL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1hdtL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1hgtL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1hltL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1hltJ						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1hrtL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1hutL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1hxeL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1hxfL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ihsL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ihtL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1lhcL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1lhdL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1lheL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1lhfL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1lhgL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1mkwL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1mkxL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1nrpL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1nrrL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1nrsL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ppbL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1qbvL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1qhrA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1qj1A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1qj6A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1qj7A						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1tbrJ						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1tbrL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1tbzL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1thpA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1thrL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1thsL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1tmbL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1tmuL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1tomL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ucyJ						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ucyL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ucyM						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1umaL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1uvsL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1uvtL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1uvuL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ycpJ						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ycpL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
2hatL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
2hgtL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
2thfA						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
3hatL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
4htcL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
4thnL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
5gdsL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
7kmeL						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
8kme1						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1a2cH01						Unbound	Unbound		Unbound	Analogue:ENO-2AC-RPH-OAR(chain R)	Unbound	Unbound
1a3bH01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:T29
1a3eH01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:T16
1a46H01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:BIC-LYS-OHO(chain R)
1a4wH01						Analogue:ANS-ARG-2EP-KTH(chain R)	Unbound		Unbound	Unbound	Unbound	Unbound
1a5gH01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:BIC-ARG-EOA(chain R)
1a61H01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:BIC-ARG-LOM(chain R)
1abiH01						Analogue:HMR_3-GLY_4(chain I)	Unbound		Unbound	Unbound	Unbound	Unbound
1abjH01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:PHE-PRO-ARG-CH2(chain I)
1ad8H01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:MDL
1ae8H01						Analogue:AZL	Unbound		Unbound	Unbound	Unbound	Unbound
1afeH01						Analogue:ALZ	Unbound		Unbound	Unbound	Unbound	Unbound
1ahtH01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:APA
1ai8H01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:T42
1aixH01						Analogue:T19	Unbound		Unbound	Unbound	Unbound	Unbound
1avgH01						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1awfH01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:GR4
1awhB01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:GR3
1awhD01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:GR3
1ay6H01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:HMF-PRO-ARG-HHO(chain I)
1b5gH01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:BCC-ARG-THZ(chain I)
1b7xB01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-bound:PHE-PRO-ARG(chain C)
1ba8B01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-bound:PMS-NVA-GLY-ARG(chain D)
1bb0B01						Analogue:PMS-NVA-GLY-3GA(chain D)	Unbound		Unbound	Unbound	Unbound	Unbound
1bbrE						Unbound	Unbound		Unbound	Bound:ARG_318(chain F)	Unbound	Unbound
1bbrK01						Unbound	Unbound		Unbound	Bound:ARG_318(chain G)	Unbound	Unbound
1bbrN01						Unbound	Unbound		Unbound	Bound:ARG_318(chain I)	Unbound	Unbound
1bcuH01						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1bhxF						Analogue:R56	Unbound		Unbound	Unbound	Unbound	Unbound
1bmmH01						Analogue:BM2	Unbound		Unbound	Unbound	Unbound	Unbound
1bmnH01						Analogue:BM9	Unbound		Unbound	Unbound	Unbound	Unbound
1bthH01						Analogue:LYS_15-ALA_16(chain P)	Unbound		Unbound	Unbound	Unbound	Unbound
1bthK01						Analogue:LYS_15-ALA_16(chain Q)	Unbound		Unbound	Unbound	Unbound	Unbound
1c1uH01						Analogue:BAI	Unbound		Unbound	Unbound	Unbound	Unbound
1c1vH01						Analogue:BAB	Unbound		Unbound	Unbound	Unbound	Unbound
1c1wH01						Analogue:BAH	Unbound		Unbound	Unbound	Unbound	Unbound
1c4u201						Analogue:IH1	Unbound		Unbound	Unbound	Unbound	Unbound
1c4v201						Analogue:IH2	Unbound		Unbound	Unbound	Unbound	Unbound
1c4y201						Analogue:IH3	Unbound		Unbound	Unbound	Unbound	Unbound
1c5lH01						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c5nH01						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c5oH01						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ca8B01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:PMS-NVA-GLY-3GA(chain D)
1d3dB01						Analogue:BZT	Unbound		Unbound	Unbound	Unbound	Unbound
1d3pB01						Analogue:BT3	Unbound		Unbound	Unbound	Unbound	Unbound
1d3qB01						Analogue:BT2	Unbound		Unbound	Unbound	Unbound	Unbound
1d3tB01						Analogue:BT1	Unbound		Unbound	Unbound	Unbound	Unbound
1d4pB01						Analogue:BPP	Unbound		Unbound	Unbound	Unbound	Unbound
1d6wA01						Analogue:AIM-HMM-SML	Unbound		Unbound	Unbound	Unbound	Unbound
1d9iA01						Analogue:CHN-HMM-SML	Unbound		Unbound	Unbound	Unbound	Unbound
1de7H01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-bound:PRO_36-ARG_37(chain A)
1de7K01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-bound:THR-VAL-GLU-LEU-GLN-GLY-VAL-VAL-PRO-ARG(chain B)
1ditH01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:ARG_4-FMT_5(chain P)
1dojA01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:CH3-DPN-PRO-AR2(chain I)
1dwcH01						Unbound	Unbound		Unbound	Analogue:MIT	Unbound	Unbound
1dwdH01						Analogue:MID	Unbound		Unbound	Unbound	Unbound	Unbound
1dweH01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:PHE-PRO-ARG-CH2(chain P)
1dx5M01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:GLU-GLY-ARM(chain E)
1dx5N01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:GLU-GLY-ARM(chain F)
1dx5O01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:GLU-GLY-ARM(chain G)
1dx5P01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:GLU-GLY-ARM(chain H)
1eojA01						Analogue:CPI_3-TIH_4(chain B)	Unbound		Unbound	Unbound	Unbound	Unbound
1eolA01						Analogue:CPI_3-NLE_4(chain B)	Unbound		Unbound	Unbound	Unbound	Unbound
1etrH01						Unbound	Unbound		Unbound	Analogue:MQI-ARG-MCP(chain M)	Unbound	Unbound
1etsH01						Analogue:NAS-GLY-APH-PIP(chain N)	Unbound		Unbound	Unbound	Unbound	Unbound
1ettH01						Analogue:TOS-APH-PIP(chain T)	Unbound		Unbound	Unbound	Unbound	Unbound
1fpcH01						Analogue:ANS-ARG-EPI(chain R)	Unbound		Unbound	Unbound	Unbound	Unbound
1fphH01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:ARG_16-CH2_17(chain F)
1h8dH01						Unbound	Unbound		Unbound	Analogue:PHW	Unbound	Unbound
1h8iH01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:PHW
1hagE01						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1hahH01						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1haiH01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:PHE-PRO-ARG-CH2(chain I)
1haoH01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:PHE-PRO-ARG-CH2(chain P)
1hapH01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:PHE-PRO-ARG-CH2(chain P)
1hbtH01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:ARG_3-PAA_3(chain I)
1hdtH01						Analogue:ALG-PHE-ALO-PHE-CH3(chain I)	Unbound		Unbound	Unbound	Unbound	Unbound
1hgtH01						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1hltH01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:PHE-PRO-ARG-CH2(chain I)
1hltK01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:PHE-PRO-ARG-CH2(chain M)
1hrtH01						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1hutH01						Unbound	Unbound		Unbound	Analogue:PHE-PRO-ARG-CH2(chain I)	Unbound	Unbound
1hxeH01						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1hxfH01						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ihsH01						Analogue:ARG_3-CBG_3(chain I)	Unbound		Unbound	Unbound	Unbound	Unbound
1ihtH01						Analogue:ARG_3-PTL_3(chain I)	Unbound		Unbound	Unbound	Unbound	Unbound
1lhcH01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:DP7
1lhdH01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:DI2
1lheH01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:DI3
1lhfH01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:DI4
1lhgH01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:DI5
1mkwH01						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1mkwK01						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1mkxH01						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1mkxK01						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1nrpH01						Analogue:LEU-ASP-PRO-HMR-SER	Unbound		Unbound	Unbound	Unbound	Unbound
1nrrH01						Unbound	Unbound		Unbound	Analogue:PHE-PRO-ARG-CH2(chain P)	Unbound	Unbound
1nrsH01						Unbound	Unbound		Unbound	Bound:LEU-ASP-PRO-ARG(chain R)	Unbound	Unbound
1ppbH01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:PHE-PRO-ARG-CH2(chain I)
1qbvH01						Analogue:PPX	Unbound		Unbound	Unbound	Unbound	Unbound
1qhrB01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:157
1qj1B01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:166
1qj6B01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:167
1qj7B01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:GR1
1tbrH01						Analogue:HIS_10-ALA_11(chain R)	Unbound		Unbound	Unbound	Unbound	Unbound
1tbrK01						Analogue:HIS_10-ALA_11(chain S)	Unbound		Unbound	Unbound	Unbound	Unbound
1tbzH01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:DPN-PRO-ARG-THZ(chain R)
1thpB01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:PHE-PRO-ARG-CH2(chain C)
1thrH01						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1thsH01						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1tmbH01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:FOR-ALA-PRO-ARG-FOR-PHE-AHT(chain T)
1tmtH01						Unbound	Unbound		Unbound	Bound:PHE-PRO-ARG(chain I)	Unbound	Unbound
1tmuH01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:PHE-PRO-ARG-CH2(chain I)
1tomH01						Analogue:MIN	Unbound		Unbound	Unbound	Unbound	Unbound
1ucyE						Analogue:OPR_16(chain F)	Unbound		Unbound	Unbound	Unbound	Unbound
1ucyK01						Analogue:OPR_16(chain G)	Unbound		Unbound	Unbound	Unbound	Unbound
1ucyN01						Analogue:OPR_16(chain I)	Unbound		Unbound	Unbound	Unbound	Unbound
1umaH01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:IN2
1uvsH01						Analogue:I11	Unbound		Unbound	Unbound	Unbound	Unbound
1uvtH01						Analogue:I48	Unbound		Unbound	Unbound	Unbound	Unbound
1uvuH01						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ycpH01						Bound:GLY-VAL-ARG-GLY-PRO(chain F)	Unbound		Unbound	Unbound	Unbound	Unbound
1ycpM						Bound:GLY-VAL-ARG-GLY-PRO(chain N)	Unbound		Unbound	Unbound	Unbound	Unbound
2hatH01						Unbound	Unbound		Unbound	Analogue:MBN-ABN-RNG-GLY-VAL-ARG-CH3(chain T)	Unbound	Unbound
2hgtH01						Unbound	Unbound		Unbound	Bound:PHE-PRO-ARG(chain I)	Unbound	Unbound
2thfB01						Unbound	Unbound		Unbound	Unbound	Unbound	Intermediate-analogue:PHE-PRO-ARG-CH2(chain C)
3hatH01						Unbound	Unbound		Unbound	Bound:RNG-GLY-VAL-ARG(chain T)	Unbound	Unbound
4htcH01						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
4thnH01						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
5gdsH01						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
7kmeH01						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
8kme201						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1a2cH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1a3bH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1a3eH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1a46H02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1a4wH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1a5gH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1a61H02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1abiH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1abjH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ad8H02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ae8H02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1afeH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ahtH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ai8H02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1aixH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1avgH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1awfH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1awhB02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1awhD02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ay6H02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1b5gH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1b7xB02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ba8B02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1bb0B02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1bbrH						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1bbrK02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1bbrN02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1bcuH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1bhxB						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1bmmH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1bmnH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1bthH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1bthK02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c1uH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c1vH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c1wH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c4u202						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c4v202						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c4y202						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c5lH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c5nH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1c5oH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ca8B02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1d3dB02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1d3pB02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1d3qB02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1d3tB02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1d4pB02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1d6wA02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1d9iA02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1de7H02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1de7K02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ditH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1dojA02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1dwcH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1dwdH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1dweH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1dx5M02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1dx5N02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1dx5O02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1dx5P02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1eojA02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1eolA02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1etrH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1etsH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ettH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1fpcH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1fphH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1h8dH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1h8iH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1hagE02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1hahH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1haiH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1haoH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1hapH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1hbtH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1hdtH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1hgtH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1hltH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1hltK02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1hrtH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1hutH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1hxeH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1hxfH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ihsH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ihtH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1lhcH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1lhdH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1lheH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1lhfH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1lhgH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1mkwH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1mkwK02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1mkxH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1mkxK02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1nrpH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1nrrH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1nrsH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ppbH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1qbvH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1qhrB02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1qj1B02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1qj6B02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1qj7B02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1tbrH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1tbrK02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1tbzH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1thpB02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1thrH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1thsH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1tmbH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1tmtH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1tmuH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1tomH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ucyH						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ucyK02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ucyN02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1umaH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1uvsH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1uvtH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1uvuH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ycpH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
1ycpK						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
2hatH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
2hgtH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
2thfB02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
3hatH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
4htcH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
4thnH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
5gdsH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
7kmeH02						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound
8kme202						Unbound	Unbound		Unbound	Unbound	Unbound	Unbound

Reference for Active-site residues
resource	references	E.C.

Active-site residues
PDB						Catalytic residues	Cofactor-binding residues	Modified residues	Main-chain involved in catalysis	Comment
1a2cL
1a3bL
1a3eL
1a46L
1a4wL
1a5gL
1a61L
1abiL
1abjL
1ad8L
1ae8L
1afeL
1ahtL
1ai8L
1aixL
1avgL
1awfL
1awhA
1awhB
1ay6L
1b5gL
1b7xA
1ba8A
1bb0A
1bbrJ
1bbrL
1bbrM
1bcuL
1bhxA
1bmmL
1bmnL
1bthL
1bthJ
1c1uL
1c1vL
1c1wL
1c4u1
1c4v1
1c4y1
1c5lL
1c5nL
1c5oL
1ca8A
1d3dA
1d3pA
1d3qA
1d3tA
1d4pA
1de7L
1de7K
1ditL
1dwcL
1dwdL
1dweL
1dx5A
1dx5B
1dx5C
1dx5D
1etrL
1etsL
1ettL
1fpcL
1fphL
1h8dL
1h8iL
1hahL
1haiL
1haoL
1hapL
1hbtL
1hdtL
1hgtL
1hltL
1hltJ
1hrtL
1hutL
1hxeL
1hxfL
1ihsL
1ihtL
1lhcL
1lhdL
1lheL
1lhfL
1lhgL
1mkwL
1mkxL
1nrpL
1nrrL
1nrsL
1ppbL
1qbvL
1qhrA
1qj1A
1qj6A
1qj7A
1tbrJ
1tbrL
1tbzL
1thpA
1thrL
1thsL
1tmbL
1tmuL
1tomL
1ucyJ
1ucyL
1ucyM
1umaL
1uvsL
1uvtL
1uvuL
1ycpJ
1ycpL
2hatL
2hgtL
2thfA
3hatL
4htcL
4thnL
5gdsL
7kmeL
8kme1
1a2cH01						SER 195			GLY 193;SER 195
1a3bH01						SER 195			GLY 193;SER 195
1a3eH01						SER 195			GLY 193;SER 195
1a46H01						SER 195			GLY 193;SER 195
1a4wH01						SER 195			GLY 193;SER 195
1a5gH01						SER 195			GLY 193;SER 195
1a61H01						SER 195			GLY 193;SER 195
1abiH01						SER 195			GLY 193;SER 195
1abjH01						SER 195			GLY 193;SER 195
1ad8H01						SER 195			GLY 193;SER 195
1ae8H01						SER 195			GLY 193;SER 195
1afeH01						SER 195			GLY 193;SER 195
1ahtH01						SER 195			GLY 193;SER 195
1ai8H01						SER 195			GLY 193;SER 195
1aixH01						SER 195			GLY 193;SER 195
1avgH01						SER 195			GLY 193;SER 195
1awfH01						SER 195			GLY 193;SER 195
1awhB01						SER 195			GLY 193;SER 195
1awhD01						SER 195			GLY 193;SER 195
1ay6H01						SER 195			GLY 193;SER 195
1b5gH01						SER 195			GLY 193;SER 195
1b7xB01						SER 195			GLY 193;SER 195	mutant Y225I
1ba8B01						SER 195			GLY 193;SER 195
1bb0B01						SER 195			GLY 193;SER 195
1bbrE						SER 195			GLY 193;SER 195
1bbrK01						SER 195			GLY 193;SER 195
1bbrN01						SER 195			GLY 193;SER 195
1bcuH01						SER 195			GLY 193;SER 195
1bhxF						SER 195			GLY 193;SER 195
1bmmH01						SER 195			GLY 193;SER 195
1bmnH01						SER 195			GLY 193;SER 195
1bthH01						SER 195			GLY 193;SER 195	mutant E192Q
1bthK01						SER 195			GLY 193;SER 195	mutant E192Q
1c1uH01						SER 201			GLY 199;SER 201
1c1vH01						SER 201			GLY 199;SER 201
1c1wH01						SER 201			GLY 199;SER 201
1c4u201						SER 195			GLY 193;SER 195
1c4v201						SER 195			GLY 193;SER 195
1c4y201						SER 195			GLY 193;SER 195
1c5lH01						SER 195			GLY 193;SER 195
1c5nH01						SER 195			GLY 193;SER 195
1c5oH01						SER 195			GLY 193;SER 195
1ca8B01						SER 195			GLY 193;SER 195
1d3dB01						SER 241			GLY 239;SER 241
1d3pB01						SER 241			GLY 239;SER 241
1d3qB01						SER 241			GLY 239;SER 241
1d3tB01						SER 241			GLY 239;SER 241
1d4pB01						SER 241			GLY 239;SER 241
1d6wA01						SER 195			GLY 193;SER 195
1d9iA01						SER 195			GLY 193;SER 195
1de7H01						SER 195			GLY 193;SER 195
1de7K01						SER 195			GLY 193;SER 195
1ditH01						SER 195			GLY 193;SER 195
1dojA01						SER 195			GLY 193;SER 195
1dwcH01						SER 195			GLY 193;SER 195
1dwdH01						SER 195			GLY 193;SER 195
1dweH01						SER 195			GLY 193;SER 195
1dx5M01						SER 195			GLY 193;SER 195
1dx5N01						SER 195			GLY 193;SER 195
1dx5O01						SER 195			GLY 193;SER 195
1dx5P01						SER 195			GLY 193;SER 195
1eojA01						SER 195			GLY 193;SER 195
1eolA01						SER 195			GLY 193;SER 195
1etrH01						SER 195			GLY 193;SER 195
1etsH01						SER 195			GLY 193;SER 195
1ettH01						SER 195			GLY 193;SER 195
1fpcH01						SER 195			GLY 193;SER 195
1fphH01						SER 195			GLY 193;SER 195
1h8dH01						SER 195			GLY 193;SER 195
1h8iH01						SER 195			GLY 193;SER 195
1hagE01						SER 195			GLY 193;SER 195
1hahH01						SER 195			GLY 193;SER 195
1haiH01						SER 195			GLY 193;SER 195
1haoH01						SER 195			GLY 193;SER 195
1hapH01						SER 195			GLY 193;SER 195
1hbtH01						SER 195			GLY 193;SER 195
1hdtH01						SER 195			GLY 193;SER 195
1hgtH01						SER 195			GLY 193;SER 195
1hltH01						SER 195			GLY 193;SER 195
1hltK01						SER 195			GLY 193;SER 195
1hrtH01						SER 195			GLY 193;SER 195
1hutH01						SER 195			GLY 193;SER 195
1hxeH01						SER 195			GLY 193;SER 195
1hxfH01						SER 195			GLY 193;SER 195
1ihsH01						SER 195			GLY 193;SER 195
1ihtH01						SER 195			GLY 193;SER 195
1lhcH01						SER 195			GLY 193;SER 195
1lhdH01						SER 195			GLY 193;SER 195
1lheH01						SER 195			GLY 193;SER 195
1lhfH01						SER 195			GLY 193;SER 195
1lhgH01						SER 195			GLY 193;SER 195
1mkwH01						SER 195			GLY 193;SER 195
1mkwK01						SER 195			GLY 193;SER 195
1mkxH01						SER 195			GLY 193;SER 195
1mkxK01						SER 195			GLY 193;SER 195
1nrpH01						SER 195			GLY 193;SER 195
1nrrH01						SER 195			GLY 193;SER 195
1nrsH01						SER 195			GLY 193;SER 195
1ppbH01						SER 195			GLY 193;SER 195
1qbvH01						SER 195			GLY 193;SER 195
1qhrB01						SER 195			GLY 193;SER 195
1qj1B01						SER 195			GLY 193;SER 195
1qj6B01						SER 195			GLY 193;SER 195
1qj7B01						SER 195			GLY 193;SER 195
1tbrH01						SER 195			GLY 193;SER 195
1tbrK01						SER 195			GLY 193;SER 195
1tbzH01						SER 195			GLY 193;SER 195
1thpB01						SER 195			GLY 193;SER 195	mutant Y225P
1thrH01						SER 195			GLY 193;SER 195
1thsH01						SER 195			GLY 193;SER 195
1tmbH01						SER 195			GLY 193;SER 195
1tmtH01						SER 195			GLY 193;SER 195
1tmuH01						SER 195			GLY 193;SER 195
1tomH01						SER 195			GLY 193;SER 195
1ucyE						SER 195			GLY 193;SER 195
1ucyK01						SER 195			GLY 193;SER 195
1ucyN01						SER 195			GLY 193;SER 195
1umaH01						SER 195			GLY 193;SER 195
1uvsH01						SER 195			GLY 193;SER 195
1uvtH01						SER 195			GLY 193;SER 195
1uvuH01						SER 195			GLY 193;SER 195
1ycpH01						SER 195			GLY 193;SER 195
1ycpM						SER 195			GLY 193;SER 195
2hatH01						SER 195			GLY 193;SER 195
2hgtH01						SER 195			GLY 193;SER 195
2thfB01						SER 195			GLY 193;SER 195	mutant Y225F
3hatH01						SER 195			GLY 193;SER 195
4htcH01						SER 195			GLY 193;SER 195
4thnH01						SER 195			GLY 193;SER 195
5gdsH01						SER 195			GLY 193;SER 195
7kmeH01						SER 195			GLY 193;SER 195
8kme201						SER 195			GLY 193;SER 195
1a2cH02						HIS 57;ASP 102
1a3bH02						HIS 57;ASP 102
1a3eH02						HIS 57;ASP 102
1a46H02						HIS 57;ASP 102
1a4wH02						HIS 57;ASP 102
1a5gH02						HIS 57;ASP 102
1a61H02						HIS 57;ASP 102
1abiH02						HIS 57;ASP 102
1abjH02						HIS 57;ASP 102
1ad8H02						HIS 57;ASP 102
1ae8H02						HIS 57;ASP 102
1afeH02						HIS 57;ASP 102
1ahtH02						HIS 57;ASP 102
1ai8H02						HIS 57;ASP 102
1aixH02						HIS 57;ASP 102
1avgH02						HIS 57;ASP 102
1awfH02						HIS 57;ASP 102
1awhB02						HIS 57;ASP 102
1awhD02						HIS 57;ASP 102
1ay6H02						HIS 57;ASP 102
1b5gH02						HIS 57;ASP 102
1b7xB02						HIS 57;ASP 102
1ba8B02						HIS 57;ASP 102
1bb0B02						HIS 57;ASP 102
1bbrH						HIS 57;ASP 102
1bbrK02						HIS 57;ASP 102
1bbrN02						HIS 57;ASP 102
1bcuH02						HIS 57;ASP 102
1bhxB						HIS 57;ASP 102
1bmmH02						HIS 57;ASP 102
1bmnH02						HIS 57;ASP 102
1bthH02						HIS 57;ASP 102
1bthK02						HIS 57;ASP 102
1c1uH02						HIS 57;ASP 102
1c1vH02						HIS 57;ASP 102
1c1wH02						HIS 57;ASP 102
1c4u202						HIS 57;ASP 102
1c4v202						HIS 57;ASP 102
1c4y202						HIS 57;ASP 102
1c5lH02						HIS 57;ASP 102
1c5nH02						HIS 57;ASP 102
1c5oH02						HIS 57;ASP 102
1ca8B02						HIS 57;ASP 102
1d3dB02						HIS 79;ASP 135
1d3pB02						HIS 79;ASP 135
1d3qB02						HIS 79;ASP 135
1d3tB02						HIS 79;ASP 135
1d4pB02						HIS 79;ASP 135
1d6wA02						HIS 57;ASP 102
1d9iA02						HIS 57;ASP 102
1de7H02						HIS 57;ASP 102
1de7K02						HIS 57;ASP 102
1ditH02						HIS 57;ASP 102
1dojA02						HIS 57;ASP 102
1dwcH02						HIS 57;ASP 102
1dwdH02						HIS 57;ASP 102
1dweH02						HIS 57;ASP 102
1dx5M02						HIS 57;ASP 102
1dx5N02						HIS 57;ASP 102
1dx5O02						HIS 57;ASP 102
1dx5P02						HIS 57;ASP 102
1eojA02						HIS 57;ASP 102
1eolA02						HIS 57;ASP 102
1etrH02						HIS 57;ASP 102
1etsH02						HIS 57;ASP 102
1ettH02						HIS 57;ASP 102
1fpcH02						HIS 57;ASP 102
1fphH02						HIS 57;ASP 102
1h8dH02						HIS 57;ASP 102
1h8iH02						HIS 57;ASP 102
1hagE02						HIS 57;ASP 102
1hahH02						HIS 57;ASP 102
1haiH02						HIS 57;ASP 102
1haoH02						HIS 57;ASP 102
1hapH02						HIS 57;ASP 102
1hbtH02						HIS 57;ASP 102
1hdtH02						HIS 57;ASP 102
1hgtH02						HIS 57;ASP 102
1hltH02						HIS 57;ASP 102
1hltK02						HIS 57;ASP 102
1hrtH02						HIS 57;ASP 102
1hutH02						HIS 57;ASP 102
1hxeH02						HIS 57;ASP 102
1hxfH02						HIS 57;ASP 102
1ihsH02						HIS 57;ASP 102
1ihtH02						HIS 57;ASP 102
1lhcH02						HIS 57;ASP 102
1lhdH02						HIS 57;ASP 102
1lheH02						HIS 57;ASP 102
1lhfH02						HIS 57;ASP 102
1lhgH02						HIS 57;ASP 102
1mkwH02						HIS 57;ASP 102
1mkwK02						HIS 57;ASP 102
1mkxH02						HIS 57;ASP 102
1mkxK02						HIS 57;ASP 102
1nrpH02						HIS 57;ASP 102
1nrrH02						HIS 57;ASP 102
1nrsH02						HIS 57;ASP 102
1ppbH02						HIS 57;ASP 102
1qbvH02						HIS 57;ASP 102
1qhrB02						HIS 57;ASP 102
1qj1B02						HIS 57;ASP 102
1qj6B02						HIS 57;ASP 102
1qj7B02						HIS 57;ASP 102
1tbrH02						HIS 57;ASP 102
1tbrK02						HIS 57;ASP 102
1tbzH02						HIS 57;ASP 102
1thpB02						HIS 57;ASP 102
1thrH02						HIS 57;ASP 102
1thsH02						HIS 57;ASP 102
1tmbH02						HIS 57;ASP 102
1tmtH02						HIS 57;ASP 102
1tmuH02						HIS 57;ASP 102
1tomH02						HIS 57;ASP 102
1ucyH						HIS 57;ASP 102
1ucyK02						HIS 57;ASP 102
1ucyN02						HIS 57;ASP 102
1umaH02						HIS 57;ASP 102
1uvsH02						HIS 57;ASP 102
1uvtH02						HIS 57;ASP 102
1uvuH02						HIS 57;ASP 102
1ycpH02						HIS 57;ASP 102
1ycpK						HIS 57;ASP 102
2hatH02						HIS 57;ASP 102
2hgtH02						HIS 57;ASP 102
2thfB02						HIS 57;ASP 102
3hatH02						HIS 57;ASP 102
4htcH02						HIS 57;ASP 102
4thnH02						HIS 57;ASP 102
5gdsH02						HIS 57;ASP 102
7kmeH02						HIS 57;ASP 102
8kme202						HIS 57;ASP 102

References for Catalytic Mechanism
References	Sections	No. of steps in catalysis
[85]	Fig.7, p.553-554	4
[89]	Fig.3

References
[1]
Resource
Comments	X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF ACTIVATION PEPTIDE 1.
Medline ID	86296631
PubMed ID	3741841
Journal	Biochemistry
Year	1986
Volume	25
Pages	3977-82
Authors	Park CH, Tulinsky A
Title	Three-dimensional structure of the kringle sequence: structure of prothrombin fragment 1.
Related PDB
Related UniProtKB	P00735
[2]
Resource
Comments	VARIANT DYSPROTHROMBINEMIA VAL-601.
Medline ID	89247398
PubMed ID	2719946
Journal	Biochemistry
Year	1989
Volume	28
Pages	2078-82
Authors	Henriksen RA, Mann KG
Title	Substitution of valine for glycine-558 in the congenital dysthrombin thrombin Quick II alters primary substrate specificity.
Related PDB
Related UniProtKB	P00734
[3]
Resource
Comments	X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
Medline ID	90059942
PubMed ID	2583108
Journal	EMBO J
Year	1989
Volume	8
Pages	3467-75
Authors	Bode W, Mayr I, Baumann U, Huber R, Stone SR, Hofsteenge J
Title	The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment.
Related PDB	1ppb
Related UniProtKB	P00734
[4]
Resource
Comments
Medline ID
PubMed ID	2369893
Journal	EMBO J
Year	1990
Volume	9
Pages	2361-5
Authors	Grutter MG, Priestle JP, Rahuel J, Grossenbacher H, Bode W, Hofsteenge J, Stone SR
Title	Crystal structure of the thrombin-hirudin complex: a novel mode of serine protease inhibition.
Related PDB
Related UniProtKB
[5]
Resource
Comments	X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
Medline ID	90327074
PubMed ID	2374926
Journal	Science
Year	1990
Volume	249
Pages	277-80
Authors	Rydel TJ, Ravichandran KG, Tulinsky A, Bode W, Huber R, Roitsch C, Fenton JW 2nd
Title	The structure of a complex of recombinant hirudin and human alpha-thrombin.
Related PDB
Related UniProtKB	P00734
[6]
Resource
Comments
Medline ID
PubMed ID	1751488
Journal	Biochemistry
Year	1991
Volume	30
Pages	11694-9
Authors	Gan ZR, Lewis SD, Stone JR, Shafer JA
Title	Reconstitution of catalytically competent human zeta-thrombin by combination of zeta-thrombin residues A1-36 and B1-148 and an Escherichia coli expressed polypeptide corresponding to zeta-thrombin residues B149-259.
Related PDB
Related UniProtKB
[7]
Resource
Comments
Medline ID
PubMed ID	1911776
Journal	Biochemistry
Year	1991
Volume	30
Pages	9841-8
Authors	Stone SR, Betz A, Hofsteenge J
Title	Mechanistic studies on thrombin catalysis.
Related PDB
Related UniProtKB
[8]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	1939071
Journal	J Biol Chem
Year	1991
Volume	266
Pages	20085-93
Authors	Banner DW, Hadvary P
Title	Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors.
Related PDB	1dwc 1dwd 1dwe
Related UniProtKB
[9]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	1920434
Journal	J Mol Biol
Year	1991
Volume	221
Pages	583-601
Authors	Rydel TJ, Tulinsky A, Bode W, Huber R
Title	Refined structure of the hirudin-thrombin complex.
Related PDB	4htc
Related UniProtKB
[10]
Resource
Comments	X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF ACTIVATION PEPTIDE 1.
Medline ID	91311686
PubMed ID	1856869
Journal	J Mol Biol
Year	1991
Volume	220
Pages	481-94
Authors	Seshadri TP, Tulinsky A, Skrzypczak-Jankun E, Park CH
Title	Structure of bovine prothrombin fragment 1 refined at 2.25 A resolution.
Related PDB
Related UniProtKB	P00735
[11]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	1942057
Journal	J Mol Biol
Year	1991
Volume	221
Pages	1379-93
Authors	Skrzypczak-Jankun E, Carperos VE, Ravichandran KG, Tulinsky A, Westbrook M, Maraganore JM
Title	Structure of the hirugen and hirulog 1 complexes of alpha-thrombin.
Related PDB	1hgt 2hgt
Related UniProtKB
[12]
Resource
Comments
Medline ID
PubMed ID	1850875
Journal	Thromb Haemost
Year	1991
Volume	65
Pages	40-5
Authors	Nienaber VL, Berliner LJ
Title	Subtle differences in active site structure between bovine and human thrombins: ESR and fluorescence studies.
Related PDB
Related UniProtKB
[13]
Resource
Comments	VARIANT DYSPROTHROMBINEMIA ALA-509.
Medline ID	92378975
PubMed ID	1354985
Journal	Biochemistry
Year	1992
Volume	31
Pages	7457-62
Authors	Miyata T, Aruga R, Umeyama H, Bezeaud A, Guillin MC, Iwanaga S
Title	Prothrombin Salakta: substitution of glutamic acid-466 by alanine reduces the fibrinogen clotting activity and the esterase activity.
Related PDB
Related UniProtKB	P00734
[14]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	1445905
Journal	Biochemistry
Year	1992
Volume	31
Pages	11689-97
Authors	Qiu X, Padmanabhan KP, Carperos VE, Tulinsky A, Kline T, Maraganore JM, Fenton JW 2nd
Title	Structure of the hirulog 3-thrombin complex and nature of the S' subsites of substrates and inhibitors.
Related PDB	1abi 1abj
Related UniProtKB
[15]
Resource
Comments	X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF ACTIVATION PEPTIDE 1.
Medline ID	92190185
PubMed ID	1547238
Journal	Biochemistry
Year	1992
Volume	31
Pages	2554-66
Authors	Soriano-Garcia M, Padmanabhan K, de Vos AM, Tulinsky A
Title	The Ca2+ ion and membrane binding structure of the Gla domain of Ca-prothrombin fragment 1.
Related PDB
Related UniProtKB	P00735
[16]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	1587268
Journal	Eur J Biochem
Year	1992
Volume	206
Pages	187-95
Authors	Stubbs MT, Oschkinat H, Mayr I, Huber R, Angliker H, Stone SR, Bode W
Title	The interaction of thrombin with fibrinogen. A structural basis for its specificity.
Related PDB	1fph
Related UniProtKB
[17]
Resource
Comments	X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
Medline ID	92218459
PubMed ID	1560020
Journal	J Biol Chem
Year	1992
Volume	267
Pages	7911-20
Authors	Martin PD, Robertson W, Turk D, Huber R, Bode W, Edwards BF
Title	The structure of residues 7-16 of the A alpha-chain of human fibrinogen bound to bovine thrombin at 2.3-A resolution.
Related PDB	1bbr
Related UniProtKB	P00735
[18]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	1517214
Journal	J Biol Chem
Year	1992
Volume	267
Pages	17670-8
Authors	Vitali J, Martin PD, Malkowski MG, Robertson WD, Lazar JB, Winant RC, Johnson PH, Edwards BF
Title	The structure of a complex of bovine alpha-thrombin and recombinant hirudin at 2.8-A resolution.
Related PDB	1hrt
Related UniProtKB
[19]
Resource
Comments	X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
Medline ID	92389319
PubMed ID	1518046
Journal	J Mol Biol
Year	1992
Volume	226
Pages	1085-99
Authors	Brandstetter H, Turk D, Hoeffken HW, Grosse D, Sturzebecher J, Martin PD, Edwards BF, Bode W
Title	Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics.
Related PDB	1etr 1ets 1ett
Related UniProtKB	P00735
[20]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	1304349
Journal	Protein Sci
Year	1992
Volume	1
Pages	426-71
Authors	Bode W, Turk D, Karshikov A
Title	The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships.
Related PDB	1ai8
Related UniProtKB
[21]
Resource
Comments
Medline ID
PubMed ID	8154332
Journal	Adv Exp Med Biol
Year	1993
Volume	340
Pages	15-26
Authors	Bode W
Title	X-ray crystal structures of thrombin in complex with D-Phe-Pro-Arg and with small benzamidine- and arginine-based "non-peptidic" inhibitors.
Related PDB
Related UniProtKB
[22]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	8102368
Journal	J Biol Chem
Year	1993
Volume	268
Pages	17651-4
Authors	Padmanabhan K, Padmanabhan KP, Ferrara JD, Sadler JE, Tulinsky A
Title	The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer.
Related PDB	1hut 1hut
Related UniProtKB
[23]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	8376390
Journal	J Biol Chem
Year	1993
Volume	268
Pages	20318-26
Authors	Qiu X, Yin M, Padmanabhan KP, Krstenansky JL, Tulinsky A
Title	Structures of thrombin complexes with a designed and a natural exosite peptide inhibitor.
Related PDB	1thr 1ths
Related UniProtKB
[24]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	8367461
Journal	Proc Natl Acad Sci U S A
Year	1993
Volume	90
Pages	8048-52
Authors	Maryanoff BE, Qiu X, Padmanabhan KP, Tulinsky A, Almond HR Jr, Andrade-Gordon P, Greco MN, Kauffman JA, Nicolaou KC, Liu A, et al
Title	Molecular basis for the inhibition of human alpha-thrombin by the macrocyclic peptide cyclotheonamide A.
Related PDB	1ay6 1tmb
Related UniProtKB
[25]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	8251938
Journal	Protein Sci
Year	1993
Volume	2
Pages	1630-42
Authors	Priestle JP, Rahuel J, Rink H, Tones M, Grutter MG
Title	Changes in interactions in complexes of hirudin derivatives and human alpha-thrombin due to different crystal forms.
Related PDB	1tmt 1tmu
Related UniProtKB
[26]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	8272424
Journal	Proteins
Year	1993
Volume	17
Pages	252-65
Authors	Zdanov A, Wu S, DiMaio J, Konishi Y, Li Y, Wu X, Edwards BF, Martin PD, Cygler M
Title	Crystal structure of the complex of human alpha-thrombin and nonhydrolyzable bifunctional inhibitors, hirutonin-2 and hirutonin-6.
Related PDB	1a3b 1a3c 1ihs 1iht
Related UniProtKB
[27]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	8136362
Journal	Biochemistry
Year	1994
Volume	33
Pages	3266-79
Authors	Mathews II, Padmanabhan KP, Ganesh V, Tulinsky A, Ishii M, Chen J, Turck CW, Coughlin SR, Fenton JW 2nd
Title	Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes.
Related PDB	1nrp 1nrr 1nrs
Related UniProtKB
[28]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	7947765
Journal	Biochemistry
Year	1994
Volume	33
Pages	13547-52
Authors	Mathews II, Padmanabhan KP, Tulinksy A, Sadler JE
Title	Structure of a nonadecapeptide of the fifth EGF domain of thrombomodulin complexed with thrombin.
Related PDB	1hlt
Related UniProtKB
[29]
Resource
Comments
Medline ID
PubMed ID	7981204
Journal	Biochemistry
Year	1994
Volume	33
Pages	14443-51
Authors	Tsuda Y, Cygler M, Gibbs BF, Pedyczak A, Fethiere J, Yue SY, Konishi Y
Title	Design of potent bivalent thrombin inhibitors based on hirudin sequence: incorporation of nonsubstrate-type active site inhibitors.
Related PDB
Related UniProtKB
[30]
Resource
Comments
Medline ID
PubMed ID	8288594
Journal	J Biol Chem
Year	1994
Volume	269
Pages	1301-5
Authors	Gan ZR, Li Y, Chen Z, Lewis SD, Shafer JA
Title	Identification of basic amino acid residues in thrombin essential for heparin-catalyzed inactivation by antithrombin III.
Related PDB
Related UniProtKB
[31]
Resource
Comments	X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
Medline ID	94350942
PubMed ID	8071320
Journal	J Biol Chem
Year	1994
Volume	269
Pages	22000-6
Authors	Rydel TJ, Yin M, Padmanabhan KP, Blankenship DT, Cardin AD, Correa PE, Fenton JW 2nd, Tulinsky A
Title	Crystallographic structure of human gamma-thrombin.
Related PDB
Related UniProtKB	P00734
[32]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	7756983
Journal	Protein Sci
Year	1994
Volume	3
Pages	2254-71
Authors	Vijayalakshmi J, Padmanabhan KP, Mann KG, Tulinsky A
Title	The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin.
Related PDB	1hag 1hah 1hai
Related UniProtKB
[33]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID
Journal	Acta Crystallogr D Biol Crystallogr
Year	1995
Volume	51
Pages	550-9
Authors	Mathews II, Tulinsky A
Title	Active-site mimetic inhibition of thrombin.
Related PDB	1fpc
Related UniProtKB
[34]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	7574675
Journal	Arch Biochem Biophys
Year	1995
Volume	322
Pages	198-203
Authors	Chen Z, Li Y, Mulichak AM, Lewis SD, Shafer JA
Title	Crystal structure of human alpha-thrombin complexed with hirugen and p-amidinophenylpyruvate at 1.6 A resolution.
Related PDB	1aht
Related UniProtKB
[35]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	7547884
Journal	Biochemistry
Year	1995
Volume	34
Pages	11537-44
Authors	Rehse PH, Steinmetzer T, Li Y, Konishi Y, Cygler M
Title	Crystal structure of a peptidyl pyridinium methyl ketone inhibitor with thrombin.
Related PDB	1hbt
Related UniProtKB
[36]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	7893672
Journal	Biochemistry
Year	1995
Volume	34
Pages	3750-7
Authors	Weber PC, Lee SL, Lewandowski FA, Schadt MC, Chang CW, Kettner CA
Title	Kinetic and crystallographic studies of thrombin with Ac-(D)Phe-Pro-boroArg-OH and its lysine, amidine, homolysine, and ornithine analogs.
Related PDB	1lhc 1lhd 1lhe 1lhf 1lhg
Related UniProtKB
[37]
Resource
Comments
Medline ID
PubMed ID	7582986
Journal	Bioorg Med Chem
Year	1995
Volume	3
Pages	1145-56
Authors	St Laurent DR, Balasubramanian N, Han WT, Trehan A, Federici ME, Meanwell NA, Wright JJ, Seiler SM
Title	Active site-directed thrombin inhibitors--II. Studies related to arginine/guanidine bioisosteres.
Related PDB
Related UniProtKB
[38]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	7489704
Journal	EMBO J
Year	1995
Volume	14
Pages	5149-57
Authors	van de Locht A, Lamba D, Bauer M, Huber R, Friedrich T, Kroger B, Hoffken W, Bode W
Title	Two heads are better than one: crystal structure of the insect derived double domain Kazal inhibitor rhodniin in complex with thrombin.
Related PDB	1tbr
Related UniProtKB
[39]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	7853394
Journal	J Mol Biol
Year	1995
Volume	246
Pages	14-20
Authors	Tabernero L, Chang CY, Ohringer SL, Lau WF, Iwanowicz EJ, Han WC, Wang TC, Seiler SM, Roberts DG, Sack JS
Title	Structure of a retro-binding peptide inhibitor complexed with human alpha-thrombin.
Related PDB	1hdt
Related UniProtKB
[40]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID
Journal	Acta Crystallogr D Biol Crystallogr
Year	1996
Volume	52
Pages	272-82
Authors	Padmanabhan K, Tulinsky A
Title	An ambiguous structure of a DNA 15-mer thrombin complex.
Related PDB	1hao 1hap
Related UniProtKB
[41]
Resource
Comments
Medline ID
PubMed ID	8753800
Journal	Biochem Biophys Res Commun
Year	1996
Volume	225
Pages	557-61
Authors	Balliano G, Milla P, Giordano C, Gallina C, Coletta M, Menegatti E, Rizzi M, Bolognesi M, Ascenzi P
Title	N-ethoxycarbonyl-D-phenylalanyl-L-prolyl-alpha-azalysine p-nitrophenyl ester: a novel, high selective and optimal chromogenic active site titrant for human and bovine alpha-, beta- and gamma-thrombin.
Related PDB
Related UniProtKB
[42]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	8855938
Journal	Biochemistry
Year	1996
Volume	35
Pages	13030-9
Authors	Martin PD, Malkowski MG, DiMaio J, Konishi Y, Ni F, Edwards BF
Title	Bovine thrombin complexed with an uncleavable analog of residues 7-19 of fibrinogen A alpha: geometry of the catalytic triad and interactions of the P1', P2', and P3' substrate residues.
Related PDB	1ucy
Related UniProtKB
[43]
Resource
Comments
Medline ID
PubMed ID	8718936
Journal	Biomaterials
Year	1996
Volume	17
Pages	903-12
Authors	Charef S, Tapon-Bretaudiere J, Fischer AM, Pfluger F, Jozefowicz M, Labarre D
Title	Heparin-like functionalized polymer surfaces: discrimination between catalytic and adsorption processes during the course of thrombin inhibition.
Related PDB
Related UniProtKB
[44]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	8913620
Journal	Biophys J
Year	1996
Volume	71
Pages	2830-9
Authors	Matthews JH, Krishnan R, Costanzo MJ, Maryanoff BE, Tulinsky A
Title	Crystal structures of thrombin with thiazole-containing inhibitors: probes of the S1' binding site.
Related PDB	1a4w 1tbz
Related UniProtKB
[45]
Resource
Comments	X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF COMPLEX WITH ORNITHODORIN.
Medline ID	97102783
PubMed ID	8947023
Journal	EMBO J
Year	1996
Volume	15
Pages	6011-7
Authors	van de Locht A, Stubbs MT, Bode W, Friedrich T, Bollschweiler C, Hoffken W, Huber R
Title	The ornithodorin-thrombin crystal structure, a key to the TAP enigma?
Related PDB
Related UniProtKB	P00735
[46]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	8637015
Journal	J Mol Biol
Year	1996
Volume	258
Pages	851-9
Authors	Nardini M, Pesce A, Rizzi M, Casale E, Ferraccioli R, Balliano G, Milla P, Ascenzi P, Bolognesi M
Title	Human alpha-thrombin inhibition by the active site titrant N alpha-(N,N-dimethylcarbamoyl)-alpha-azalysine p-nitrophenyl ester: a comparative kinetic and X-ray crystallographic study.
Related PDB	1uma
Related UniProtKB
[47]
Resource
Comments
Medline ID
PubMed ID	8762149
Journal	Protein Sci
Year	1996
Volume	5
Pages	1174-83
Authors	Fethiere J, Tsuda Y, Coulombe R, Konishi Y, Cygler M
Title	Crystal structure of two new bifunctional nonsubstrate type thrombin inhibitors complexed with human alpha-thrombin.
Related PDB
Related UniProtKB
[48]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	8868478
Journal	Protein Sci
Year	1996
Volume	5
Pages	422-33
Authors	Krishnan R, Tulinsky A, Vlasuk GP, Pearson D, Vallar P, Bergum P, Brunck TK, Ripka WC
Title	Synthesis, structure, and structure-activity relationships of divalent thrombin inhibitors containing an alpha-keto-amide transition-state mimetic.
Related PDB	1dit
Related UniProtKB
[49]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	8745399
Journal	Protein Sci
Year	1996
Volume	5
Pages	221-8
Authors	Malley MF, Tabernero L, Chang CY, Ohringer SL, Roberts DG, Das J, Sack JS
Title	Crystallographic determination of the structures of human alpha-thrombin complexed with BMS-186282 and BMS-189090.
Related PDB	1bmm 1bmn
Related UniProtKB
[50]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	8939759
Journal	Structure
Year	1996
Volume	4
Pages	1353-62
Authors	Engh RA, Brandstetter H, Sucher G, Eichinger A, Baumann U, Bode W, Huber R, Poll T, Rudolph R, von der Saal W
Title	Enzyme flexibility, solvent and 'weak' interactions characterize thrombin-ligand interactions: implications for drug design.
Related PDB	1uvs 1uvt 1uvu
Related UniProtKB
[51]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	9307032
Journal	Biochem J
Year	1997
Volume	326
Pages	815-22
Authors	Malkowski MG, Martin PD, Lord ST, Edwards BF
Title	Crystal structure of fibrinogen-Aalpha peptide 1-23 (F8Y) bound to bovine thrombin explains why the mutation of Phe-8 to tyrosine strongly inhibits normal cleavage at Arg-16.
Related PDB	1ycp
Related UniProtKB
[52]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	9033393
Journal	Biochemistry
Year	1997
Volume	36
Pages	1034-40
Authors	Malikayil JA, Burkhart JP, Schreuder HA, Broersma RJ Jr, Tardif C, Kutcher LW 3rd, Mehdi S, Schatzman GL, Neises B, Peet NP
Title	Molecular design and characterization of an alpha-thrombin inhibitor containing a novel P1 moiety.
Related PDB	1ad8
Related UniProtKB
[53]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID
Journal	Bioorg Med Chem Lett
Year	1997
Volume	7
Pages	67-72
Authors	Lyle TA, Chen Z, Applebyd SD, Freidingerb RM, Gardella SJ, Lewisa SD, Lia Y, Lyled EA, Lynch Jr. JJ, Mulichaka AM, Nga AS, Naylor-Olsenc AM, Sanders WM
Title	Synthesis, evaluation, and crystallographic analysis of L-371,912: A potent and selective active-site thrombin inhibitor.
Related PDB	1tom
Related UniProtKB
[54]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	9108691
Journal	Biophys Chem
Year	1997
Volume	63
Pages	185-200
Authors	Zhang E, Tulinsky A
Title	The molecular environment of the Na+ binding site of thrombin.
Related PDB	1hxe 1hxf
Related UniProtKB
[55]
Resource
Comments
Medline ID
PubMed ID	9195869
Journal	Chem Biol
Year	1997
Volume	4
Pages	287-95
Authors	Obst U, Banner DW, Weber L, Diederich F
Title	Molecular recognition at the thrombin active site: structure-based design and synthesis of potent and selective thrombin inhibitors and the X-ray crystal structures of two thrombin-inhibitor complexes.
Related PDB
Related UniProtKB
[56]
Resource
Comments	X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
Medline ID	97357286
PubMed ID	9214615
Journal	EMBO J
Year	1997
Volume	16
Pages	2977-84
Authors	van de Locht A, Bode W, Huber R, Le Bonniec BF, Stone SR, Esmon CT, Stubbs MT
Title	The thrombin E192Q-BPTI complex reveals gross structural rearrangements: implications for the interaction with antithrombin and thrombomodulin.
Related PDB	1bth
Related UniProtKB	P00734
[57]
Resource
Comments
Medline ID
PubMed ID	9357512
Journal	J Med Chem
Year	1997
Volume	40
Pages	3489-93
Authors	Sall DJ, Bastian JA, Briggs SL, Buben JA, Chirgadze NY, Clawson DK, Denney ML, Giera DD, Gifford-Moore DS, Harper RW, Hauser KL, Klimkowski VJ, Kohn TJ, Lin HS, McCowan JR, Palkowitz AD, Smith GF, Takeuchi K, Thrasher KJ, Tinsley JM, Utterback BG, Yan SC, Zhang M
Title	Dibasic benzo[b]thiophene derivatives as a novel class of active site-directed thrombin inhibitors. 1. Determination of the serine protease selectivity, structure-activity relationships, and binding orientation.
Related PDB
Related UniProtKB
[58]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	9217260
Journal	J Mol Biol
Year	1997
Volume	269
Pages	558-69
Authors	De Simone G, Balliano G, Milla P, Gallina C, Giordano C, Tarricone C, Rizzi M, Bolognesi M, Ascenzi P
Title	Human alpha-thrombin inhibition by the highly selective compounds N-ethoxycarbonyl-D-Phe-Pro-alpha-azaLys p-nitrophenyl ester and N-carbobenzoxy-Pro-alpha-azaLys p-nitrophenyl ester: a kinetic, thermodynamic and X-ray crystallographic study.
Related PDB	1ae8 1afe
Related UniProtKB
[59]
Resource
Comments	X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF COMPLEX WITH TRIABIN.
Medline ID	98004486
PubMed ID	9342325
Journal	Proc Natl Acad Sci U S A
Year	1997
Volume	94
Pages	11845-50
Authors	Fuentes-Prior P, Noeske-Jungblut C, Donner P, Schleuning WD, Huber R, Bode W
Title	Structure of the thrombin complex with triabin, a lipocalin-like exosite-binding inhibitor derived from a triatomine bug.
Related PDB	1avg
Related UniProtKB	P00735
[60]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	9232642
Journal	Protein Sci
Year	1997
Volume	6
Pages	1412-7
Authors	Chirgadze NY, Sall DJ, Klimkowski VJ, Clawson DK, Briggs SL, Hermann R, Smith GF, Gifford-Moore DS, Wery JP
Title	The crystal structure of human alpha-thrombin complexed with LY178550, a nonpeptidyl, active site-directed inhibitor.
Related PDB	1d4p
Related UniProtKB
[61]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	9232645
Journal	Protein Sci
Year	1997
Volume	6
Pages	1438-48
Authors	Malkowski MG, Martin PD, Guzik JC, Edwards BF
Title	The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding.
Related PDB	1mkw 1mkx
Related UniProtKB
[62]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	9724521
Journal	Biochemistry
Year	1998
Volume	37
Pages	12094-103
Authors	Krishnan R, Zhang E, Hakansson K, Arni RK, Tulinsky A, Lim-Wilby MS, Levy OE, Semple JE, Brunck TK
Title	Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes.
Related PDB	1ba8 1bb0 1ca8
Related UniProtKB
[63]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	9578548
Journal	Biochemistry
Year	1998
Volume	37
Pages	6645-57
Authors	Weir MP, Bethell SS, Cleasby A, Campbell CJ, Dennis RJ, Dix CJ, Finch H, Jhoti H, Mooney CJ, Patel S, Tang CM, Ward M, Wonacott AJ, Wharton CW
Title	Novel natural product 5,5-trans-lactone inhibitors of human alpha-thrombin: mechanism of action and structural studies.
Related PDB	1awf 1awh
Related UniProtKB
[64]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	9559654
Journal	FEBS Lett
Year	1998
Volume	425
Pages	229-33
Authors	Conti E, Rivetti C, Wonacott A, Brick P
Title	X-ray and spectrophotometric studies of the binding of proflavin to the S1 specificity pocket of human alpha-thrombin.
Related PDB	1bcu
Related UniProtKB
[65]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID
Journal	J Am Chem Soc
Year	1998
Volume	120
Pages	597-8
Authors	Rios-Steiner JL, Murakami M, Tulinsky A
Title	Structure of Thrombin Inhibited by Aeruginosin 298-A from a Blue-Green Alga.
Related PDB	1a2c
Related UniProtKB
[66]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	9622548
Journal	J Med Chem
Year	1998
Volume	41
Pages	2068-75
Authors	Bone R, Lu T, Illig CR, Soll RM, Spurlino JC
Title	Structural analysis of thrombin complexed with potent inhibitors incorporating a phenyl group as a peptide mimetic and aminopyridines as guanidine substitutes.
Related PDB	1qbv
Related UniProtKB
[67]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	9733491
Journal	J Med Chem
Year	1998
Volume	41
Pages	3664-74
Authors	Wagner J, Kallen J, Ehrhardt C, Evenou JP, Wagner D
Title	Rational design, synthesis, and X-ray structure of selective noncovalent thrombin inhibitors.
Related PDB	1bhx
Related UniProtKB
[68]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	9468142
Journal	Nature
Year	1998
Volume	391
Pages	608-12
Authors	Katz BA, Clark JM, Finer-Moore JS, Jenkins TE, Johnson CR, Ross MJ, Luong C, Moore WR, Stroud RM
Title	Design of potent selective zinc-mediated serine protease inhibitors.
Related PDB	1c1u 1c1v 1c1w
Related UniProtKB
[69]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	9521099
Journal	Protein Sci
Year	1998
Volume	7
Pages	243-53
Authors	De Simone G, Lombardi A, Galdiero S, Nastri F, Della Morte R, Staiano N, Pedone C, Bolognesi M, Pavone V
Title	Hirunorms are true hirudin mimetics. The crystal structure of human alpha-thrombin-hirunorm V complex.
Related PDB	5gds
Related UniProtKB
[70]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	10089309
Journal	Acta Crystallogr D Biol Crystallogr
Year	1999
Volume	55
Pages	785-93
Authors	Mochalkin I, Tulinsky A
Title	Structures of thrombin retro-inhibited with SEL2711 and SEL2770 as they relate to factor Xa binding.
Related PDB	7kme 8kme
Related UniProtKB
[71]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	10387040
Journal	Biochemistry
Year	1999
Volume	38
Pages	7969-77
Authors	Jhoti H, Cleasby A, Reid S, Thomas PJ, Weir M, Wonacott A
Title	Crystal structures of thrombin complexed to a novel series of synthetic inhibitors containing a 5,5-trans-lactone template.
Related PDB	1qhr 1qj1 1qj6 1qj7
Related UniProtKB
[72]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	10212123
Journal	J Med Chem
Year	1999
Volume	42
Pages	1376-83
Authors	St Charles R, Matthews JH, Zhang E, Tulinsky A
Title	Bound structures of novel P3-P1' beta-strand mimetic inhibitors of thrombin.
Related PDB	1a46 1a5g 1a61 1b5g
Related UniProtKB
[73]
Resource
Comments	X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 328-601.
Medline ID	99162521
PubMed ID	10051558
Journal	Proc Natl Acad Sci U S A
Year	1999
Volume	96
Pages	1852-7
Authors	Guinto ER, Caccia S, Rose T, Futterer K, Waksman G, Di Cera E
Title	Unexpected crucial role of residue 225 in serine proteases.
Related PDB	1b7x 1thp 2thf
Related UniProtKB	P00734
[74]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	10210187
Journal	Protein Sci
Year	1999
Volume	8
Pages	91-5
Authors	Lombardi A, De Simone G, Nastri F, Galdiero S, Della Morte R, Staiano N, Pedone C, Bolognesi M, Pavone V
Title	The crystal structure of alpha-thrombin-hirunorm IV complex reveals a novel specificity site recognition mode.
Related PDB	4thn
Related UniProtKB
[75]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	10713516
Journal	Acta Crystallogr D Biol Crystallogr
Year	2000
Volume	56
Pages	294-303
Authors	Krishnan R, Mochalkin I, Arni R, Tulinsky A
Title	Structure of thrombin complexed with selective non-electrophilic inhibitors having cyclohexyl moieties at P1.
Related PDB	1c4u 1c4v 1c4y 1d6w 1d9i
Related UniProtKB
[76]
Resource
Comments
Medline ID
PubMed ID	10739913
Journal	Acta Crystallogr D Biol Crystallogr
Year	2000
Volume	56
Pages	406-10
Authors	Krishnan R, Sadler JE, Tulinsky A
Title	Structure of the Ser195Ala mutant of human alpha--thrombin complexed with fibrinopeptide A(7--16): evidence for residual catalytic activity.
Related PDB
Related UniProtKB
[77]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	11053836
Journal	Acta Crystallogr D Biol Crystallogr
Year	2000
Volume	56
Pages	1395-400
Authors	Recacha R, Costanzo MJ, Maryanoff BE, Carson M, DeLucas L, Chattopadhyay D
Title	Structure of human alpha-thrombin complexed with RWJ-51438 at 1.7 A: unusual perturbation of the 60A-60I insertion loop.
Related PDB	1doj
Related UniProtKB
[78]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	10694407
Journal	Biochemistry
Year	2000
Volume	39
Pages	2384-91
Authors	Slon-Usakiewicz JJ, Sivaraman J, Li Y, Cygler M, Konishi Y
Title	Design of P1' and P3' residues of trivalent thrombin inhibitors and their crystal structures.
Related PDB	1eoj 1eol
Related UniProtKB
[79]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	10779411
Journal	Chem Biol
Year	2000
Volume	7
Pages	299-312
Authors	Katz BA, Mackman R, Luong C, Radika K, Martelli A, Sprengeler PA, Wang J, Chan H, Wong L
Title	Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
Related PDB	1c5l 1c5n 1c5o
Related UniProtKB
[80]
Resource
Comments
Medline ID
PubMed ID	11060016
Journal	EMBO J
Year	2000
Volume	19
Pages	5650-60
Authors	Richardson JL, Kroger B, Hoeffken W, Sadler JE, Pereira P, Huber R, Bode W, Fuentes-Prior P
Title	Crystal structure of the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor.
Related PDB
Related UniProtKB
[81]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	10956659
Journal	J Biol Chem
Year	2000
Volume	275
Pages	36942-8
Authors	Sadasivan C, Yee VC
Title	Interaction of the factor XIII activation peptide with alpha -thrombin. Crystal structure of its enzyme-substrate analog complex.
Related PDB	1de7
Related UniProtKB
[82]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	10761923
Journal	Nature
Year	2000
Volume	404
Pages	518-25
Authors	Fuentes-Prior P, Iwanaga Y, Huber R, Pagila R, Rumennik G, Seto M, Morser J, Light DR, Bode W
Title	Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex.
Related PDB	1dx5
Related UniProtKB
[83]
Resource
Comments
Medline ID
PubMed ID	10739244
Journal	Protein Sci
Year	2000
Volume	9
Pages	29-36
Authors	Chirgadze NY, Sall DJ, Briggs SL, Clawson DK, Zhang M, Smith GF, Schevitz RW
Title	The crystal structures of human alpha-thrombin complexed with active site-directed diamino benzo[b]thiophene derivatives: a binding mode for a structurally novel class of inhibitors.
Related PDB
Related UniProtKB
[84]
Resource
Comments
Medline ID
PubMed ID	11513582
Journal	Biochemistry
Year	2001
Volume	40
Pages	10038-46
Authors	Wang SX, Esmon CT, Fletterick RJ
Title	Crystal structure of thrombin-ecotin reveals conformational changes and extended interactions.
Related PDB
Related UniProtKB
[85]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	11493008
Journal	J Mol Biol
Year	2001
Volume	311
Pages	549-55
Authors	Skordalakes E, Dodson GG, Green DS, Goodwin CA, Scully MF, Hudson HR, Kakkar VV, Deadman JJ
Title	Inhibition of human alpha-thrombin by a phosphonate tripeptide proceeds via a metastable pentacoordinated phosphorus intermediate.
Related PDB	1h8d 1h8i
Related UniProtKB
[86]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	11342132
Journal	Structure (Camb)
Year	2001
Volume	9
Pages	29-37
Authors	Nar H, Bauer M, Schmid A, Stassen JM, Wienen W, Priepke HW, Kauffmann IK, Ries UJ, Hauel NH
Title	Structural basis for inhibition promiscuity of dual specific thrombin and factor Xa blood coagulation inhibitors.
Related PDB	1d3d 1d3p 1d3q 1d3t
Related UniProtKB
[87]
Resource
Comments
Medline ID
PubMed ID	11827547
Journal	Biochemistry
Year	2002
Volume	41
Pages	2002-13
Authors	Thuring JW, Li H, Porter NA
Title	Comparative study of the active site caging of serine proteases: thrombin and factor Xa.
Related PDB
Related UniProtKB
[88]
Resource
Comments
Medline ID
PubMed ID	12205081
Journal	J Biol Chem
Year	2002
Volume	277
Pages	40177-80
Authors	Pineda AO, Savvides SN, Waksman G, Di Cera E
Title	Crystal structure of the anticoagulant slow form of thrombin.
Related PDB
Related UniProtKB
[89]
Resource
Comments
Medline ID
PubMed ID	12885234
Journal	Biochemistry
Year	2003
Volume	42
Pages	9013-21
Authors	De Simone G, Menchise V, Omaggio S, Pedone C, Scozzafava A, Supuran CT
Title	Design of weakly basic thrombin inhibitors incorporating novel P1 binding functions: molecular and X-ray crystallographic studies.
Related PDB
Related UniProtKB
[90]
Resource
Comments
Medline ID
PubMed ID	12954052
Journal	J Med Chem
Year	2003
Volume	46
Pages	3985-4001
Authors	Nilsson JW, Kvarnstrom I, Musil D, Nilsson I, Samulesson B
Title	Synthesis and SAR of thrombin inhibitors incorporating a novel 4-amino-morpholinone sscaffold: analysis of X-ray crystal structure of enzyme inhibitor complex.
Related PDB
Related UniProtKB
[91]
Resource
Comments
Medline ID
PubMed ID	14523451
Journal	Nature
Year	2003
Volume	425
Pages	535-9
Authors	Friedrich R, Panizzi P, Fuentes-Prior P, Richter K, Verhamme I, Anderson PJ, Kawabata S, Huber R, Bode W, Bock PE
Title	Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation.
Related PDB
Related UniProtKB
[92]
Resource
Comments
Medline ID
PubMed ID	12855810
Journal	Science
Year	2003
Volume	301
Pages	218-21
Authors	Celikel R, McClintock RA, Roberts JR, Mendolicchio GL, Ware J, Varughese KI, Ruggeri ZM
Title	Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha.
Related PDB
Related UniProtKB
[93]
Resource
Comments
Medline ID
PubMed ID	12855811
Journal	Science
Year	2003
Volume	301
Pages	222-6
Authors	Dumas JJ, Kumar R, Seehra J, Somers WS, Mosyak L
Title	Crystal structure of the GpIbalpha-thrombin complex essential for platelet aggregation.
Related PDB
Related UniProtKB

Comments

This enzyme belongs to the peptidase family-S1. This enzyme is composed of light chain and heavy chain. Chain L (light chain) of PDB structures corresponds to the residues 328-363 of Swiss-prot P00734 or the residues 318-366 of Swiss-prot P00735, whilst chain H (heavy chain) of PDB structures corresponds to the residues 364-622 of Swiss-prot P00734 or the residues 367-625 of Swiss-prot P00735. This enzyme has got the classical catalytic triad, Ser/His/Asp, along with "oxyanion hole" coposed of mainchain amide groups. The catalytic serine residue acts as a nucleophile to form a covalent-bonded intermediate, whilst the histidine residue acts as acid/base, which assists the nucleophile by abstracting a proton from the serine residue.

Created	Updated
2004-10-08	2010-02-18