DB code: M00212
| RLCP classification | 1.13.30000.10 : Hydrolysis | |
|---|---|---|
| CATH domain | 2.10.25.10 : Laminin | |
| 2.10.25.10 : Laminin | ||
| 2.40.10.10 : Thrombin, subunit H | Catalytic domain | |
| 2.40.10.10 : Thrombin, subunit H | Catalytic domain | |
| E.C. | 3.4.21.69 | |
| CSA | ||
| M-CSA | ||
| MACiE | ||
| CATH domain | Related DB codes (homologues) |
|---|---|
| 2.10.25.10 : Laminin | M00139 M00133 M00152 M00155 M00315 M00316 |
| 2.40.10.10 : Thrombin, subunit H | M00139 D00214 M00167 D00426 M00133 D00428 D00429 D00430 D00431 D00432 D00433 D00434 D00435 M00227 M00209 D00194 D00197 D00211 D00212 D00216 D00224 D00497 M00217 M00216 D00528 D00848 D00850 D00851 D00852 D00855 M00152 M00155 M00157 M00181 M00315 M00316 M00317 M00348 M00349 T00074 T00410 T00411 |
| Uniprot Enzyme Name | UniprotKB | Protein name | Synonyms | Contains | RefSeq | MEROPS | Pfam |
|---|---|---|---|---|---|---|
| P04070 |
Vitamin K-dependent protein C
|
EC
3.4.21.69
Autoprothrombin IIA Anticoagulant protein C Blood coagulation factor XIV |
Vitamin K-dependent protein C light chain
Vitamin K-dependent protein C heavy chain Activation peptide |
NP_000303.1
(Protein)
NM_000312.3 (DNA/RNA sequence) |
S01.218
(Serine)
|
PF00594
(Gla)
PF00089 (Trypsin) [Graphical View] |
| KEGG enzyme name |
|---|
|
protein C (activated)
blood-coagulation factor XIVa activated blood coagulation factor XIV activated protein C autoprothrombin II-A protein Ca APC GSAPC |
| UniprotKB: Accession Number | Entry name | Activity | Subunit | Subcellular location | Cofactor |
|---|---|---|---|---|---|
| P04070 | PROC_HUMAN | Degradation of blood coagulation factors Va and VIIIa. | Synthesized as a single chain precursor, which is cleaved into a light chain and a heavy chain held together by a disulfide bond. The enzyme is then activated by thrombin, which cleaves a tetradecapeptide from the amino end of the heavy chain, this reaction, which occurs at the surface of endothelial cells, is strongly promoted by thrombomodulin. |
| KEGG Pathways | Map code | Pathways | E.C. |
|---|
| Compound table | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Substrates | Products | Intermediates | ||||||||||||
| KEGG-id | C03780 | C04001 | C00017 | C00001 | C00017 | C00012 | I00087 | I00085 | I00086 | |||||
| E.C. | ||||||||||||||
| Compound | Blood coagulation Factor Va | Blood coagulation Factor VIIIa | Protein | H2O | Protein | Peptide | Peptidyl-tetrahedral intermediate | Acyl-enzyme | Tetrahedral intermediate | |||||
| Type | peptide/protein | peptide/protein | peptide/protein | H2O | peptide/protein | peptide/protein | ||||||||
| ChEBI |
15377 15377 |
|||||||||||||
| PubChem |
22247451 962 22247451 962 |
|||||||||||||
| 1autL01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1autL02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1autC01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:DPN-PRO-MAI(chain P) | |
| 1autC02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| Reference for Active-site residues | ||
|---|---|---|
| resource | references | E.C. |
| Swiss-prot;P04070 & literature [29], [35] | ||
| Active-site residues | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Catalytic residues | Cofactor-binding residues | Modified residues | Main-chain involved in catalysis | Comment | |||||
| 1autL01 |
|
|
|
|
|
|||||
| 1autL02 |
|
|
|
|
|
|||||
| 1autC01 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1autC02 |
|
|
|
|
|
HIS 57;ASP 102 | ||||
| References for Catalytic Mechanism | ||
|---|---|---|
| References | Sections | No. of steps in catalysis |
|
[29]
|
||
| References | |
|---|---|
| [1] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 3584108 |
| Journal | J Biol Chem |
| Year | 1987 |
| Volume | 262 |
| Pages | 7105-8 |
| Authors | Hill KA, Castellino FJ |
| Title | Topographical relationships between the monovalent and divalent cation binding sites of des-1-41-light chain bovine plasma protein C and des-1-41-light chain-activated bovine plasma protein C. |
| Related PDB | |
| Related UniProtKB | |
| [2] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 3584107 |
| Journal | J Biol Chem |
| Year | 1987 |
| Volume | 262 |
| Pages | 7098-104 |
| Authors | Hill KA, Steiner SA, Castellino FJ |
| Title | 205Tl+ as a spectroscopic probe of the monovalent cation binding sites of bovine plasma activated protein C and des-1-41-light-chain-activated protein C. |
| Related PDB | |
| Related UniProtKB | |
| [3] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 2839161 |
| Journal | Biochem J |
| Year | 1988 |
| Volume | 251 |
| Pages | 229-36 |
| Authors | Hill KA, Steiner SA, Castellino FJ |
| Title | Estimation of the distance between the divalent cation binding site of des-1-41-light chain-activated bovine plasma protein C and a nitroxide spin label attached to the active-site serine residue. |
| Related PDB | |
| Related UniProtKB | |
| [4] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 2538457 |
| Journal | J Biol Chem |
| Year | 1989 |
| Volume | 264 |
| Pages | 4743-6 |
| Authors | Esmon CT |
| Title | The roles of protein C and thrombomodulin in the regulation of blood coagulation. |
| Related PDB | |
| Related UniProtKB | |
| [5] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1939075 |
| Journal | J Biol Chem |
| Year | 1991 |
| Volume | 266 |
| Pages | 20139-45 |
| Authors | Fay PJ, Smudzin TM, Walker FJ |
| Title |
Activated protein C-catalyzed inactivation of human factor VIII and factor VIIIa. |
| Related PDB | |
| Related UniProtKB | |
| [6] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1761551 |
| Journal | J Biol Chem |
| Year | 1991 |
| Volume | 266 |
| Pages | 24514-9 |
| Authors | Mesters RM, Houghten RA, Griffin JH |
| Title | Identification of a sequence of human activated protein C (residues 390-404) essential for its anticoagulant activity. |
| Related PDB | |
| Related UniProtKB | |
| [7] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1657904 |
| Journal | J Biol Chem |
| Year | 1991 |
| Volume | 266 |
| Pages | 19886-9 |
| Authors | Zushi M, Gomi K, Honda G, Kondo S, Yamamoto S, Hayashi T, Suzuki K |
| Title | Aspartic acid 349 in the fourth epidermal growth factor-like structure of human thrombomodulin plays a role in its Ca(2+)-mediated binding to protein C. |
| Related PDB | |
| Related UniProtKB | |
| [8] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1317308 |
| Journal | FASEB J |
| Year | 1992 |
| Volume | 6 |
| Pages | 2561-7 |
| Authors | Walker FJ, Fay PJ |
| Title | Regulation of blood coagulation by the protein C system. |
| Related PDB | |
| Related UniProtKB | |
| [9] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1309772 |
| Journal | J Biol Chem |
| Year | 1992 |
| Volume | 267 |
| Pages | 703-6 |
| Authors | Hogg PJ, Ohlin AK, Stenflo J |
| Title | Identification of structural domains in protein C involved in its interaction with thrombin-thrombomodulin on the surface of endothelial cells. |
| Related PDB | |
| Related UniProtKB | |
| [10] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1464619 |
| Journal | J Biol Chem |
| Year | 1992 |
| Volume | 267 |
| Pages | 26078-84 |
| Authors | Zhang L, Castellino FJ |
| Title | Influence of specific gamma-carboxyglutamic acid residues on the integrity of the calcium-dependent conformation of human protein C. |
| Related PDB | |
| Related UniProtKB | |
| [11] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8216224 |
| Journal | Biochem J |
| Year | 1993 |
| Volume | 295 |
| Pages | 239-45 |
| Authors | Hermans JM, Stone SR |
| Title | Interaction of activated protein C with serpins. |
| Related PDB | |
| Related UniProtKB | |
| [12] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8251484 |
| Journal | Biochemistry |
| Year | 1993 |
| Volume | 32 |
| Pages | 12656-63 |
| Authors | Mesters RM, Heeb MJ, Griffin JH |
| Title | A novel exosite in the light chain of human activated protein C essential for interaction with blood coagulation factor Va. |
| Related PDB | |
| Related UniProtKB | |
| [13] | |
| Resource | |
| Comments | VARIANTS TRP-38; CYS-42; HIS-42; GLN-271 AND ASN-294. |
| Medline ID | 93313192 |
| PubMed ID | 8324221 |
| Journal | Blood |
| Year | 1993 |
| Volume | 82 |
| Pages | 159-68 |
| Authors | Gandrille S, Alhenc-Gelas M, Gaussem P, Aillaud MF, Dupuy E, Juhan-Vague I, Aiach M |
| Title | Five novel mutations located in exons III and IX of the protein C gene in patients presenting with defective protein C anticoagulant activity. |
| Related PDB | |
| Related UniProtKB | P04070 |
| [14] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8130392 |
| Journal | Glycobiology |
| Year | 1993 |
| Volume | 3 |
| Pages | 597-608 |
| Authors | Yan SB, Chao YB, van Halbeek H |
| Title | Novel Asn-linked oligosaccharides terminating in GalNAc beta (1-->4)[Fuc alpha (1-->3)]GlcNAc beta (1-->.) are present in recombinant human protein C expressed in human kidney 293 cells. |
| Related PDB | |
| Related UniProtKB | |
| [15] | |
| Resource | |
| Comments |
NUCLEOTIDE SEQUENCE OF 43-64 FROM NUCLEIC ACID, |
| Medline ID | 93237511 |
| PubMed ID | 8477066 |
| Journal | Int J Hematol |
| Year | 1993 |
| Volume | 57 |
| Pages | 9-14 |
| Authors | Mimuro J, Muramatsu S, Kaneko M, Yoshitake S, Iijima K, Nakamura K, Sakata Y, Matsuda M |
| Title |
An abnormal protein C (protein C Yonago) with an amino acid substitution of Gly for Arg-15 caused by a single base mutation of C to G in codon 57 (CGG-->GGG). |
| Related PDB | |
| Related UniProtKB | P04070 |
| [16] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8104182 |
| Journal | J Biol Chem |
| Year | 1993 |
| Volume | 268 |
| Pages | 19943-8 |
| Authors | Rezaie AR, Esmon CT |
| Title | Conversion of glutamic acid 192 to glutamine in activated protein C changes the substrate specificity and increases reactivity toward macromolecular inhibitors. |
| Related PDB | |
| Related UniProtKB | |
| [17] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8505327 |
| Journal | J Biol Chem |
| Year | 1993 |
| Volume | 268 |
| Pages | 12040-5 |
| Authors | Zhang L, Castellino FJ |
| Title | The contributions of individual gamma-carboxyglutamic acid residues in the calcium-dependent binding of recombinant human protein C to acidic phospholipid vesicles. |
| Related PDB | |
| Related UniProtKB | |
| [18] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8401232 |
| Journal | Protein Sci |
| Year | 1993 |
| Volume | 2 |
| Pages | 1482-9 |
| Authors | Mesters RM, Heeb MJ, Griffin JH |
| Title | Interactions and inhibition of blood coagulation factor Va involving residues 311-325 of activated protein C. |
| Related PDB | |
| Related UniProtKB | |
| [19] | |
| Resource | |
| Comments | REVIEW ON PROC VARIANTS. |
| Medline ID | 93190290 |
| PubMed ID | 8446940 |
| Journal | Thromb Haemost |
| Year | 1993 |
| Volume | 69 |
| Pages | 77-84 |
| Authors | Reitsma PH, Poort SR, Bernardi F, Gandrille S, Long GL, Sala N, Cooper DN |
| Title |
Protein C deficiency: a database of mutations. |
| Related PDB | |
| Related UniProtKB | P04070 |
| [20] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7980464 |
| Journal | Biochem J |
| Year | 1994 |
| Volume | 303 |
| Pages | 929-33 |
| Authors | Grinnell BW, Gerlitz B, Berg DT |
| Title | Identification of a region in protein C involved in thrombomodulin-stimulated activation by thrombin: potential repulsion at anion-binding site I in thrombin. |
| Related PDB | |
| Related UniProtKB | |
| [21] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8043441 |
| Journal | Br J Haematol |
| Year | 1994 |
| Volume | 86 |
| Pages | 590-600 |
| Authors | Murakawa M, Okamura T, Kamura T, Kuroiwa M, Harada M, Niho Y |
| Title | A comparative study of partial primary structures of the catalytic region of mammalian protein C. |
| Related PDB | |
| Related UniProtKB | |
| [22] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7989361 |
| Journal | J Biol Chem |
| Year | 1994 |
| Volume | 269 |
| Pages | 31869-80 |
| Authors | Kalafatis M, Rand MD, Mann KG |
| Title | The mechanism of inactivation of human factor V and human factor Va by activated protein C. |
| Related PDB | |
| Related UniProtKB | |
| [23] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7906267 |
| Journal | J Biol Chem |
| Year | 1994 |
| Volume | 269 |
| Pages | 3151-4 |
| Authors | Rezaie AR, Mather T, Sussman F, Esmon CT |
| Title | Mutation of Glu-80-->Lys results in a protein C mutant that no longer requires Ca2+ for rapid activation by the thrombin-thrombomodulin complex. |
| Related PDB | |
| Related UniProtKB | |
| [24] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8106403 |
| Journal | J Biol Chem |
| Year | 1994 |
| Volume | 269 |
| Pages | 3590-5 |
| Authors | Zhang L, Castellino FJ |
| Title | The binding energy of human coagulation protein C to acidic phospholipid vesicles contains a major contribution from leucine 5 in the gamma-carboxyglutamic acid domain. |
| Related PDB | |
| Related UniProtKB | |
| [25] | |
| Resource | |
| Comments | Model |
| Medline ID | 94272342 |
| PubMed ID | 8003977 |
| Journal | Protein Sci |
| Year | 1994 |
| Volume | 3 |
| Pages | 588-99 |
| Authors | Fisher CL, Greengard JS, Griffin JH |
| Title | Models of the serine protease domain of the human antithrombotic plasma factor activated protein C and its zymogen. |
| Related PDB | 2pct |
| Related UniProtKB | |
| [26] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7548032 |
| Journal | Biochemistry |
| Year | 1995 |
| Volume | 34 |
| Pages | 12775-81 |
| Authors | Persson E, Ezban M, Shymko RM |
| Title |
Kinetics of the interaction between the human factor VIIIa subunits: effects of pH, |
| Related PDB | |
| Related UniProtKB | |
| [27] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7547963 |
| Journal | Biochemistry |
| Year | 1995 |
| Volume | 34 |
| Pages | 12221-6 |
| Authors | Rezaie AR, Esmon CT |
| Title | Tryptophans 231 and 234 in protein C report the Ca(2+)-dependent conformational change required for activation by the thrombin-thrombomodulin complex. |
| Related PDB | |
| Related UniProtKB | |
| [28] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7673148 |
| Journal | J Biol Chem |
| Year | 1995 |
| Volume | 270 |
| Pages | 21158-66 |
| Authors | Nicolaes GA, Tans G, Thomassen MC, Hemker HC, Pabinger I, Varadi K, Schwarz HP, Rosing J |
| Title | Peptide bond cleavages and loss of functional activity during inactivation of factor Va and factor VaR506Q by activated protein C. |
| Related PDB | |
| Related UniProtKB | |
| [29] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 84-461. |
| Medline ID | 97157472 |
| PubMed ID | 9003757 |
| Journal | EMBO J |
| Year | 1996 |
| Volume | 15 |
| Pages | 6822-31 |
| Authors | Mather T, Oganessyan V, Hof P, Huber R, Foundling S, Esmon C, Bode W |
| Title | The 2.8 A crystal structure of Gla-domainless activated protein C. |
| Related PDB | 1aut |
| Related UniProtKB | P04070 |
| [30] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8902996 |
| Journal | Thromb Haemost |
| Year | 1996 |
| Volume | 76 |
| Pages | 556-60 |
| Authors | De Cristofaro R |
| Title | Effect of thrombomodulin on the molecular recognition and early catalytic events in thrombin-protein C interaction. |
| Related PDB | |
| Related UniProtKB | |
| [31] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8713779 |
| Journal | Thromb Haemost |
| Year | 1996 |
| Volume | 75 |
| Pages | 49-55 |
| Authors | Mori T, Takeya H, Nishioka J, Gabazza EC, Suzuki K |
| Title | beta 2-Glycoprotein I modulates the anticoagulant activity of activated protein C on the phospholipid surface. |
| Related PDB | |
| Related UniProtKB | |
| [32] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8815576 |
| Journal | Thromb Haemost |
| Year | 1996 |
| Volume | 75 |
| Pages | 275-82 |
| Authors | Nishioka J, Ido M, Hayashi T, Suzuki K |
| Title |
The Gla26 residue of protein C is required for the binding of protein C to thrombomodulin and endothelial cell protein C receptor, |
| Related PDB | |
| Related UniProtKB | |
| [33] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9334197 |
| Journal | J Biol Chem |
| Year | 1997 |
| Volume | 272 |
| Pages | 26279-84 |
| Authors | Regan LM, Mollica JS, Rezaie AR, Esmon CT |
| Title | The interaction between the endothelial cell protein C receptor and protein C is dictated by the gamma-carboxyglutamic acid domain of protein C. |
| Related PDB | |
| Related UniProtKB | |
| [34] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9300501 |
| Journal | Protein Sci |
| Year | 1997 |
| Volume | 6 |
| Pages | 2016-27 |
| Authors | Egan JO, Kalafatis M, Mann KG |
| Title | The effect of Arg306-->Ala and Arg506-->Gln substitutions in the inactivation of recombinant human factor Va by activated protein C and protein S. |
| Related PDB | |
| Related UniProtKB | |
| [35] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9198204 |
| Journal | Thromb Haemost |
| Year | 1997 |
| Volume | 78 |
| Pages | 501-11 |
| Authors | Bode W, Brandstetter H, Mather T, Stubbs MT |
| Title |
Comparative analysis of haemostatic proteinases: structural aspects of thrombin, |
| Related PDB | |
| Related UniProtKB | |
| [36] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9988741 |
| Journal | J Biol Chem |
| Year | 1999 |
| Volume | 274 |
| Pages | 4970-6 |
| Authors | He X, Rezaie AR |
| Title | Identification and characterization of the sodium-binding site of activated protein C. |
| Related PDB | |
| Related UniProtKB | |
| [37] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10096438 |
| Journal | Life Sci |
| Year | 1999 |
| Volume | 64 |
| Pages | 879-85 |
| Authors | Martinez-Cruz R, Cordoba F, Mireles-Lopez JC, Zenteno E, Perez-Ortega E, Martinez M, Perez-Campos E |
| Title | Effects of concanavalin A on protein-C activity. |
| Related PDB | |
| Related UniProtKB | |
| [38] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10223294 |
| Journal | Proteins |
| Year | 1999 |
| Volume | 35 |
| Pages | 218-34 |
| Authors | Knobe KE, Berntsdotter A, Shen L, Morser J, Dahlback B, Villoutreix BO |
| Title |
Probing the activation of protein C by the thrombin-thrombomodulin complex using structural analysis, |
| Related PDB | |
| Related UniProtKB | |
| [39] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10456457 |
| Journal | Thromb Haemost |
| Year | 1999 |
| Volume | 82 |
| Pages | 72-9 |
| Authors | Shen L, Villoutreix BO, Dahlback B |
| Title | Involvement of Lys 62(217) and Lys 63(218) of human anticoagulant protein C in heparin stimulation of inhibition by the protein C inhibitor. |
| Related PDB | |
| Related UniProtKB | |
| [40] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10715104 |
| Journal | Biochemistry |
| Year | 2000 |
| Volume | 39 |
| Pages | 2853-60 |
| Authors | Shen L, Dahlback B, Villoutreix BO |
| Title | Tracking structural features leading to resistance of activated protein C to alpha 1-antitrypsin. |
| Related PDB | |
| Related UniProtKB | |
| [41] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11106601 |
| Journal | Biophys J |
| Year | 2000 |
| Volume | 79 |
| Pages | 2925-43 |
| Authors | Perera L, Foley C, Darden TA, Stafford D, Mather T, Esmon CT, Pedersen LG |
| Title | Modeling zymogen protein C. |
| Related PDB | |
| Related UniProtKB | |
| [42] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10688829 |
| Journal | Blood |
| Year | 2000 |
| Volume | 95 |
| Pages | 1714-20 |
| Authors | O'Brien LM, Mastri M, Fay PJ |
| Title | Regulation of factor VIIIa by human activated protein C and protein S: inactivation of cofactor in the intrinsic factor Xase. |
| Related PDB | |
| Related UniProtKB | |
| [43] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11380450 |
| Journal | Br J Haematol |
| Year | 2001 |
| Volume | 113 |
| Pages | 642-8 |
| Authors | Lind B, Koefoed P, Thorsen S |
| Title | Symptomatic type 1 protein C deficiency caused by a de novo Ser270Leu mutation in the catalytic domain. |
| Related PDB | |
| Related UniProtKB | |
| [44] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11309403 |
| Journal | J Biol Chem |
| Year | 2001 |
| Volume | 276 |
| Pages | 23105-8 |
| Authors | Friedrich U, Nicolaes GA, Villoutreix BO, Dahlback B |
| Title | Secondary substrate-binding exosite in the serine protease domain of activated protein C important for cleavage at Arg-506 but not at Arg-306 in factor Va. |
| Related PDB | |
| Related UniProtKB | |
| [45] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11814362 |
| Journal | Biochemistry |
| Year | 2002 |
| Volume | 41 |
| Pages | 1672-80 |
| Authors | Silveira JR, Kalafatis M, Tracy PB |
| Title |
Carbohydrate moieties on the procofactor factor V, |
| Related PDB | |
| Related UniProtKB | |
| [46] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11994010 |
| Journal | Biochemistry |
| Year | 2002 |
| Volume | 41 |
| Pages | 6149-57 |
| Authors | Yang L, Manithody C, Rezaie AR |
| Title | Contribution of basic residues of the 70-80-loop to heparin binding and anticoagulant function of activated protein C. |
| Related PDB | |
| Related UniProtKB | |
| [47] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12034704 |
| Journal | J Biol Chem |
| Year | 2002 |
| Volume | 277 |
| Pages | 24851-4 |
| Authors | Oganesyan V, Oganesyan N, Terzyan S, Qu D, Dauter Z, Esmon NL, Esmon CT |
| Title | The crystal structure of the endothelial protein C receptor and a bound phospholipid. |
| Related PDB | |
| Related UniProtKB | |
| [48] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12029084 |
| Journal | J Biol Chem |
| Year | 2002 |
| Volume | 277 |
| Pages | 28987-95 |
| Authors | Schmidt AE, Padmanabhan K, Underwood MC, Bode W, Mather T, Bajaj SP |
| Title |
Thermodynamic linkage between the S1 site, |
| Related PDB | |
| Related UniProtKB | |
| [49] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12595311 |
| Journal | Blood |
| Year | 2003 |
| Volume | 101 |
| Pages | 4802-7 |
| Authors | Manithody C, Fay PJ, Rezaie AR |
| Title | Exosite-dependent regulation of factor VIIIa by activated protein C. |
| Related PDB | |
| Related UniProtKB | |
| [50] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12393635 |
| Journal | Blood |
| Year | 2003 |
| Volume | 101 |
| Pages | 20-30 |
| Authors | Mann KG, Kalafatis M |
| Title | Factor V: a combination of Dr Jekyll and Mr Hyde. |
| Related PDB | |
| Related UniProtKB | |
| [51] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12446455 |
| Journal | Blood |
| Year | 2003 |
| Volume | 101 |
| Pages | 2277-84 |
| Authors | Sun YH, Shen L, Dahlback B |
| Title | Gla domain-mutated human protein C exhibiting enhanced anticoagulant activity and increased phospholipid binding. |
| Related PDB | |
| Related UniProtKB | |
| [52] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12970121 |
| Journal | Chest |
| Year | 2003 |
| Volume | 124 |
| Pages | 26S-32S |
| Authors | Esmon CT |
| Title | The protein C pathway. |
| Related PDB | |
| Related UniProtKB | |
| [53] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12554095 |
| Journal | Trends Cardiovasc Med |
| Year | 2003 |
| Volume | 13 |
| Pages | 8-15 |
| Authors | Rezaie AR |
| Title | Exosite-dependent regulation of the protein C anticoagulant pathway. |
| Related PDB | |
| Related UniProtKB | |
| [54] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 15337738 |
| Journal | J Biol Chem |
| Year | 2004 |
| Volume | 279 |
| Pages | 47528-35 |
| Authors | Sun YH, Tran S, Norstrom EA, Dahlback B |
| Title | Enhanced rate of cleavage at Arg-306 and Arg-506 in coagulation factor Va by Gla domain-mutated human-activated protein C. |
| Related PDB | |
| Related UniProtKB | |
| [55] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 14660667 |
| Journal | J Biol Chem |
| Year | 2004 |
| Volume | 279 |
| Pages | 6567-75 |
| Authors | van der Neut Kolfschoten M, Dirven RJ, Vos HL, Tans G, Rosing J, Bertina RM |
| Title |
Factor Va is inactivated by activated protein C in the absence of cleavage sites at Arg-306, |
| Related PDB | |
| Related UniProtKB | |
| [56] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 15254039 |
| Journal | J Biol Chem |
| Year | 2004 |
| Volume | 279 |
| Pages | 38519-24 |
| Authors | Yang L, Prasad S, Di Cera E, Rezaie AR |
| Title | The conformation of the activation peptide of protein C is influenced by Ca2+ and Na+ binding. |
| Related PDB | |
| Related UniProtKB | |
| [57] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 15943976 |
| Journal | FEBS Lett |
| Year | 2005 |
| Volume | 579 |
| Pages | 3310-6 |
| Authors | Dahlback B, Villoutreix BO |
| Title | The anticoagulant protein C pathway. |
| Related PDB | |
| Related UniProtKB | |
| [58] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 16113785 |
| Journal | Thromb Haemost |
| Year | 2005 |
| Volume | 94 |
| Pages | 60-8 |
| Authors | Yang L, Manithody C, Rezaie AR |
| Title | The functional significance of the autolysis loop in protein C and activated protein C. |
| Related PDB | |
| Related UniProtKB | |
| [59] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 16418283 |
| Journal | Proc Natl Acad Sci U S A |
| Year | 2006 |
| Volume | 103 |
| Pages | 879-84 |
| Authors | Yang L, Manithody C, Rezaie AR |
| Title | Activation of protein C by the thrombin-thrombomodulin complex: Cooperative roles of Arg-35 of thrombin and Arg-67 of protein C. |
| Related PDB | |
| Related UniProtKB | |
| Comments |
|---|
|
This enzyme belongs to the peptidase family-S1.
This enzyme is composed of a light chain and a heavy chain, |
| Created | Updated |
|---|---|
| 2004-08-24 | 2011-02-21 |