DB code: M00317
| RLCP classification | 1.13.30000.10 : Hydrolysis | |
|---|---|---|
| CATH domain | 3.40.50.410 : Rossmann fold | |
| 2.40.10.10 : Thrombin, subunit H | Catalytic domain | |
| 2.40.10.10 : Thrombin, subunit H | Catalytic domain | |
| 2.-.-.- : | ||
| 2.60.40.690 : Immunoglobulin-like | ||
| 2.60.120.290 : Jelly Rolls | ||
| 1.50.10.20 : Glycosyltransferase | ||
| 2.60.40.690 : Immunoglobulin-like | ||
| 2.40.50.120 : OB fold (Dihydrolipoamide Acetyltransferase, E2P) | ||
| E.C. | 3.4.21.47 | |
| CSA | ||
| M-CSA | ||
| MACiE | ||
| CATH domain | Related DB codes (homologues) |
|---|---|
| 2.40.10.10 : Thrombin, subunit H | M00139 D00214 M00167 D00426 M00133 D00428 D00429 D00430 D00431 D00432 D00433 D00434 D00435 M00227 M00209 D00194 D00197 D00211 D00212 D00216 M00212 D00224 D00497 M00217 M00216 D00528 D00848 D00850 D00851 D00852 D00855 M00152 M00155 M00157 M00181 M00315 M00316 M00348 M00349 T00074 T00410 T00411 |
| 2.60.120.290 : Jelly Rolls | M00139 M00227 M00315 M00316 M00348 |
| Uniprot Enzyme Name | UniprotKB | Protein name | Synonyms | Contains | RefSeq | MEROPS | Pfam |
|---|---|---|---|---|---|---|
| P00751 |
Complement factor B
|
EC
3.4.21.47
C3/C5 convertase Glycine-rich beta glycoprotein GBG PBF2 Properdin factor B |
Complement factor B Ba fragment
Complement factor B Bb fragment |
NP_001701.2
(Protein)
NM_001710.5 (DNA/RNA sequence) |
S01.196
(Serine)
|
PF00084
(Sushi)
PF00089 (Trypsin) PF00092 (VWA) [Graphical View] |
| P01024 |
Complement C3
|
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1
|
Complement C3 beta chain
Complement C3 alpha chain C3a anaphylatoxin Acylation stimulating protein (ASP) C3adesArg Complement C3b alpha'' chain Complement C3c alpha'' chain fragment 1 Complement C3dg fragment Complement C3g fragment Complement C3d fragment Complement C3f fragment Complement C3c alpha'' chain fragment 2 |
NP_000055.2
(Protein)
NM_000064.2 (DNA/RNA sequence) |
I39.950
()
|
PF00207
(A2M)
PF07678 (A2M_comp) PF01835 (A2M_N) PF07703 (A2M_N_2) PF07677 (A2M_recep) PF01821 (ANATO) PF01759 (NTR) PF10569 (Thiol-ester_cl) [Graphical View] |
| Q91132 |
Cobra venom factor
|
CVF
CVFk Complement C3 homolog |
Cobra venom factor alpha chain
Cobra venom factor gamma chain Cobra venom factor beta chain |
I39.950
()
|
PF00207
(A2M)
PF07678 (A2M_comp) PF01835 (A2M_N) PF07703 (A2M_N_2) PF07677 (A2M_recep) PF01821 (ANATO) PF01759 (NTR) PF10569 (Thiol-ester_cl) [Graphical View] |
| KEGG enzyme name |
|---|
|
Alternative-complement-pathway C3/C5 convertase
Complement component C3/C5 convertase (alternative) Proenzyme factor B Properdin factor B C3 proactivator Glycine-rich beta-glycoprotein Heat-labile factor C3 convertase C3b,Bb,CVF,Bb,C5 convertase (C3b)n,Bb Complement C 3(C 5) convertase (amplification) Alternative complement pathway C3(C5) convertase C5 convertase CVF,Bb (CVF)-dependent glycine-rich-beta-glucoprotein Cobra venom factor-dependent C3 convertase |
| UniprotKB: Accession Number | Entry name | Activity | Subunit | Subcellular location | Cofactor |
|---|---|---|---|---|---|
| P00751 | CFAB_HUMAN | Cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to yield C5a and C5b. | Monomer. | Secreted. | |
| P01024 | CO3_HUMAN | C3 precursor is first processed by the removal of 4 Arg residues, forming two chains, beta and alpha, linked by a disulfide bond. C3 convertase activates C3 by cleaving the alpha chain, releasing C3a anaphylatoxin and generating C3b (beta chain + alpha' chain). During pregnancy, C3dg exists as a complex (probably a 2:2:2 heterohexamer) with AGT and the proform of PRG2. Interacts with CR2 and VSIG4. | Secreted. | ||
| Q91132 | CO3_NAJKA | Heterotrimer of alpha, beta and gamma chains. disulfide-linked. | Secreted. |
| KEGG Pathways | Map code | Pathways | E.C. |
|---|
| Compound table | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cofactors | Substrates | Products | Intermediates | |||||||||||||
| KEGG-id | C00305 | L00091 | L00092 | C00001 | L00093 | L00079 | L00094 | L00095 | I00087 | I00085 | I00086 | |||||
| E.C. | ||||||||||||||||
| Compound | Magnesium | Complement C3 alpha chain | Complement C5 alpha chain | H2O | Complement component C3a | Complement component C3b | Complement component C5a | Complement component C5b | Peptidyl-tetrahedral intermediate | Acyl-enzyme | tetrahedral intermediate | |||||
| Type | divalent metal (Ca2+, Mg2+) | peptide/protein | peptide/protein | H2O | peptide/protein | peptide/protein | peptide/protein | peptide/protein | ||||||||
| ChEBI |
18420 18420 |
15377 15377 |
||||||||||||||
| PubChem |
888 888 |
22247451 962 22247451 962 |
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| 1q0pA00 |
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Analogue:_MN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1rrkA01 |
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Analogue:_CO | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1rs0A01 |
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Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1rtkA01 |
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Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2ok5A04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winI01 |
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Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winJ01 |
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Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winK01 |
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Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winL01 |
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Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwbF04 |
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Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwbH04 |
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Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjI04 |
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Analogue:_NI | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjJ04 |
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Analogue:_NI | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjK04 |
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Analogue:_NI | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjL04 |
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Analogue:_NI | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3hrzD04 |
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Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3hs0D04 |
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Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3hs0I04 |
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Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1rrkA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1rs0A02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1rtkA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1dleA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1dleB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2ok5A05 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winI02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winJ02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winK02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winL02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwbF05 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwbH05 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjI05 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjJ05 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjK05 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjL05 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3hrzD05 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3hs0D05 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3hs0I05 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1rrkA03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1rs0A03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:DFP | Unbound | Unbound | |
| 1rtkA03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:GBS | Unbound | |
| 1dleA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1dleB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2ok5A06 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winI03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winJ03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winK03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winL03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwbF06 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwbH06 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjI06 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjJ06 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjK06 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjL06 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3hrzD06 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3hs0D06 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3hs0I06 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winD01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winF01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winH01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwbB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwbD01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjD01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjF01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjH01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3hrzB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3hs0B01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3hs0G01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winD02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winF02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winH02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwbB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwbD02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjD02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjF02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjH02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3hrzB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3hs0B02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3hs0G02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winB03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winD03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winF03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winH03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwbB03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwbD03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjB03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjD03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjF03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjH03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3hrzC01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3hs0C01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3hs0H01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winB04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winD04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winF04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winH04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwbB04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwbD04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjB04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjD04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjF04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjH04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winB05 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winD05 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winF05 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winH05 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwbB05 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwbD05 |
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|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjB05 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjD05 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjF05 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjH05 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3hrzC02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3hs0C02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3hs0H02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winB06 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winD06 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winF06 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2winH06 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwbB06 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwbD06 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjB06 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjD06 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjF06 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2xwjH06 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3hrzC03 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3hs0C03 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3hs0H03 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| Reference for Active-site residues | ||
|---|---|---|
| resource | references | E.C. |
| Literature [8] & Swiss-prot;P00751 | ||
| Active-site residues | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Catalytic residues | Cofactor-binding residues | Modified residues | Main-chain involved in catalysis | Comment | |||||
| 1q0pA00 |
|
|
|
|
|
SER 253;SER 255;THR 328(Magnesium binding) | ||||
| 1rrkA01 |
|
|
|
|
|
SER 253;SER 255;THR 328(Magnesium binding) | ||||
| 1rs0A01 |
|
|
|
|
|
SER 253;SER 255;THR 328(Magnesium binding) | ||||
| 1rtkA01 |
|
|
|
|
|
SER 253;SER 255;THR 328(Magnesium binding) | ||||
| 2ok5A04 |
|
|
|
|
|
SER 253;SER 255;THR 328(Magnesium binding) | ||||
| 2winI01 |
|
|
|
|
|
SER 253;SER 255;THR 328(Magnesium binding) | ||||
| 2winJ01 |
|
|
|
|
|
SER 253;SER 255;THR 328(Magnesium binding) | ||||
| 2winK01 |
|
|
|
|
|
SER 253;SER 255;THR 328(Magnesium binding) | ||||
| 2winL01 |
|
|
|
|
|
SER 253;SER 255;THR 328(Magnesium binding) | ||||
| 2xwbF04 |
|
|
|
|
|
SER 253;SER 255;THR 328(Magnesium binding) | ||||
| 2xwbH04 |
|
|
|
|
|
SER 253;SER 255;THR 328(Magnesium binding) | ||||
| 2xwjI04 |
|
|
|
|
|
SER 253;SER 255;THR 328(Magnesium binding) | ||||
| 2xwjJ04 |
|
|
|
|
|
SER 253;SER 255;THR 328(Magnesium binding) | ||||
| 2xwjK04 |
|
|
|
|
|
SER 253;SER 255;THR 328(Magnesium binding) | ||||
| 2xwjL04 |
|
|
|
|
|
SER 253;SER 255;THR 328(Magnesium binding) | ||||
| 3hrzD04 |
|
|
|
|
|
SER 253;SER 255;THR 328(Magnesium binding) | ||||
| 3hs0D04 |
|
|
|
|
|
SER 253;SER 255;THR 328(Magnesium binding) | ||||
| 3hs0I04 |
|
|
|
|
|
SER 253;SER 255;THR 328(Magnesium binding) | ||||
| 1rrkA02 |
|
|
|
|
|
HIS 501;ASP 551 | ||||
| 1rs0A02 |
|
|
|
|
|
HIS 501;ASP 551 | ||||
| 1rtkA02 |
|
|
|
|
|
HIS 501;ASP 551 | ||||
| 1dleA01 |
|
|
|
|
|
HIS 57;ASP 102 | ||||
| 1dleB01 |
|
|
|
|
|
HIS 57;ASP 102 | ||||
| 2ok5A05 |
|
|
|
|
|
HIS 501;ASP 551 | ||||
| 2winI02 |
|
|
|
|
|
HIS 501;ASP 551 | ||||
| 2winJ02 |
|
|
|
|
|
HIS 501;ASP 551 | ||||
| 2winK02 |
|
|
|
|
|
HIS 501;ASP 551 | ||||
| 2winL02 |
|
|
|
|
|
HIS 501;ASP 551 | ||||
| 2xwbF05 |
|
|
|
|
|
HIS 501;ASP 551 | ||||
| 2xwbH05 |
|
|
|
|
|
HIS 501;ASP 551 | ||||
| 2xwjI05 |
|
|
|
|
|
HIS 501;ASP 551 | ||||
| 2xwjJ05 |
|
|
|
|
|
HIS 501;ASP 551 | ||||
| 2xwjK05 |
|
|
|
|
|
HIS 501;ASP 551 | ||||
| 2xwjL05 |
|
|
|
|
|
HIS 501;ASP 551 | ||||
| 3hrzD05 |
|
|
|
|
|
HIS 501;ASP 551 | ||||
| 3hs0D05 |
|
|
|
|
|
HIS 501;ASP 551 | ||||
| 3hs0I05 |
|
|
|
|
|
HIS 501;ASP 551 | ||||
| 1rrkA03 |
|
|
|
|
|
SER 674 | GLY 672;SER 674 | |||
| 1rs0A03 |
|
|
|
|
|
SER 674 | GLY 672;SER 674 | |||
| 1rtkA03 |
|
|
|
|
|
SER 674 | GLY 672;SER 674 | |||
| 1dleA02 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 1dleB02 |
|
|
|
|
|
SER 195 | GLY 193;SER 195 | |||
| 2ok5A06 |
|
|
|
|
|
SER 674 | GLY 672;SER 674 | |||
| 2winI03 |
|
|
|
|
|
SER 674 | GLY 672;SER 674 | |||
| 2winJ03 |
|
|
|
|
|
SER 674 | GLY 672;SER 674 | |||
| 2winK03 |
|
|
|
|
|
SER 674 | GLY 672;SER 674 | |||
| 2winL03 |
|
|
|
|
|
SER 674 | GLY 672;SER 674 | |||
| 2xwbF06 |
|
|
|
|
|
SER 674 | GLY 672;SER 674 | |||
| 2xwbH06 |
|
|
|
|
|
SER 674 | GLY 672;SER 674 | |||
| 2xwjI06 |
|
|
|
|
|
SER 674 | GLY 672;SER 674 | |||
| 2xwjJ06 |
|
|
|
|
|
SER 674 | GLY 672;SER 674 | |||
| 2xwjK06 |
|
|
|
|
|
SER 674 | GLY 672;SER 674 | |||
| 2xwjL06 |
|
|
|
|
|
SER 674 | GLY 672;SER 674 | |||
| 3hrzD06 |
|
|
|
|
|
SER 674 | GLY 672;SER 674 | |||
| 3hs0D06 |
|
|
|
|
|
SER 674 | GLY 672;SER 674 | |||
| 3hs0I06 |
|
|
|
|
|
SER 674 | GLY 672;SER 674 | |||
| 2winB01 |
|
|
|
|
|
|||||
| 2winD01 |
|
|
|
|
|
|||||
| 2winF01 |
|
|
|
|
|
|||||
| 2winH01 |
|
|
|
|
|
|||||
| 2xwbB01 |
|
|
|
|
|
|||||
| 2xwbD01 |
|
|
|
|
|
|||||
| 2xwjB01 |
|
|
|
|
|
|||||
| 2xwjD01 |
|
|
|
|
|
|||||
| 2xwjF01 |
|
|
|
|
|
|||||
| 2xwjH01 |
|
|
|
|
|
|||||
| 3hrzB01 |
|
|
|
|
|
|||||
| 3hs0B01 |
|
|
|
|
|
|||||
| 3hs0G01 |
|
|
|
|
|
|||||
| 2winB02 |
|
|
|
|
|
|||||
| 2winD02 |
|
|
|
|
|
|||||
| 2winF02 |
|
|
|
|
|
|||||
| 2winH02 |
|
|
|
|
|
|||||
| 2xwbB02 |
|
|
|
|
|
|||||
| 2xwbD02 |
|
|
|
|
|
|||||
| 2xwjB02 |
|
|
|
|
|
|||||
| 2xwjD02 |
|
|
|
|
|
|||||
| 2xwjF02 |
|
|
|
|
|
|||||
| 2xwjH02 |
|
|
|
|
|
|||||
| 3hrzB02 |
|
|
|
|
|
|||||
| 3hs0B02 |
|
|
|
|
|
|||||
| 3hs0G02 |
|
|
|
|
|
|||||
| 2winB03 |
|
|
|
|
|
|||||
| 2winD03 |
|
|
|
|
|
|||||
| 2winF03 |
|
|
|
|
|
|||||
| 2winH03 |
|
|
|
|
|
|||||
| 2xwbB03 |
|
|
|
|
|
|||||
| 2xwbD03 |
|
|
|
|
|
|||||
| 2xwjB03 |
|
|
|
|
|
|||||
| 2xwjD03 |
|
|
|
|
|
|||||
| 2xwjF03 |
|
|
|
|
|
|||||
| 2xwjH03 |
|
|
|
|
|
|||||
| 3hrzC01 |
|
|
|
|
|
|||||
| 3hs0C01 |
|
|
|
|
|
|||||
| 3hs0H01 |
|
|
|
|
|
|||||
| 2winB04 |
|
|
|
|
|
|||||
| 2winD04 |
|
|
|
|
|
|||||
| 2winF04 |
|
|
|
|
|
|||||
| 2winH04 |
|
|
|
|
|
|||||
| 2xwbB04 |
|
|
|
|
|
|||||
| 2xwbD04 |
|
|
|
|
|
|||||
| 2xwjB04 |
|
|
|
|
|
|||||
| 2xwjD04 |
|
|
|
|
|
|||||
| 2xwjF04 |
|
|
|
|
|
|||||
| 2xwjH04 |
|
|
|
|
|
|||||
| 2winB05 |
|
|
|
|
|
|||||
| 2winD05 |
|
|
|
|
|
|||||
| 2winF05 |
|
|
|
|
|
|||||
| 2winH05 |
|
|
|
|
|
|||||
| 2xwbB05 |
|
|
|
|
|
|||||
| 2xwbD05 |
|
|
|
|
|
|||||
| 2xwjB05 |
|
|
|
|
|
|||||
| 2xwjD05 |
|
|
|
|
|
|||||
| 2xwjF05 |
|
|
|
|
|
|||||
| 2xwjH05 |
|
|
|
|
|
|||||
| 3hrzC02 |
|
|
|
|
|
|||||
| 3hs0C02 |
|
|
|
|
|
|||||
| 3hs0H02 |
|
|
|
|
|
|||||
| 2winB06 |
|
|
|
|
|
ASN 1641(Magnesium binding) | ||||
| 2winD06 |
|
|
|
|
|
ASN 1641(Magnesium binding) | ||||
| 2winF06 |
|
|
|
|
|
ASN 1641(Magnesium binding) | ||||
| 2winH06 |
|
|
|
|
|
ASN 1641(Magnesium binding) | ||||
| 2xwbB06 |
|
|
|
|
|
ASN 1641(Magnesium binding) | ||||
| 2xwbD06 |
|
|
|
|
|
ASN 1641(Magnesium binding) | ||||
| 2xwjB06 |
|
|
|
|
|
ASN 1641(Magnesium binding) | ||||
| 2xwjD06 |
|
|
|
|
|
ASN 1641(Magnesium binding) | ||||
| 2xwjF06 |
|
|
|
|
|
ASN 1641(Magnesium binding) | ||||
| 2xwjH06 |
|
|
|
|
|
ASN 1641(Magnesium binding) | ||||
| 3hrzC03 |
|
|
|
|
|
THR 1620(Magnesium binding) | ||||
| 3hs0C03 |
|
|
|
|
|
|||||
| 3hs0H03 |
|
|
|
|
|
|||||
| References for Catalytic Mechanism | ||
|---|---|---|
| References | Sections | No. of steps in catalysis |
|
[16]
|
Figure 5 | |
|
[17]
|
Figure 1 | |
|
[20]
|
Figure 1 | |
|
[21]
|
Figure 3 | |
|
[22]
|
Figure 6 | |
| References | |
|---|---|
| [1] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 6559201 |
| Journal | J Immunol |
| Year | 1984 |
| Volume | 132 |
| Pages | 1430-4 |
| Authors | Fishelson Z, Pangburn MK, Muller-Eberhard HJ |
| Title | Characterization of the initial C3 convertase of the alternative pathway of human complement. |
| Related PDB | |
| Related UniProtKB | |
| [2] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 3638964 |
| Journal | Biochem J |
| Year | 1986 |
| Volume | 235 |
| Pages | 723-30 |
| Authors | Pangburn MK, Muller-Eberhard HJ |
| Title |
The C3 convertase of the alternative pathway of human complement. |
| Related PDB | |
| Related UniProtKB | |
| [3] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 3643213 |
| Journal | J Biol Chem |
| Year | 1987 |
| Volume | 262 |
| Pages | 1519-25 |
| Authors | Pryzdial EL, Isenman DE |
| Title |
Alternative complement pathway activation fragment Ba binds to C3b. |
| Related PDB | |
| Related UniProtKB | |
| [4] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 2433342 |
| Journal | J Immunol |
| Year | 1987 |
| Volume | 138 |
| Pages | 1143-9 |
| Authors | Ueda A, Kearney JF, Roux KH, Volanakis JE |
| Title |
Probing functional sites on complement protein B with monoclonal antibodies. |
| Related PDB | |
| Related UniProtKB | |
| [5] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 3183384 |
| Journal | J Immunol |
| Year | 1988 |
| Volume | 141 |
| Pages | 3895-901 |
| Authors | Kinoshita T, Takata Y, Kozono H, Takeda J, Hong KS, Inoue K |
| Title | C5 convertase of the alternative complement pathway: covalent linkage between two C3b molecules within the trimolecular complex enzyme. |
| Related PDB | |
| Related UniProtKB | |
| [6] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7649982 |
| Journal | J Biol Chem |
| Year | 1995 |
| Volume | 270 |
| Pages | 19716-22 |
| Authors | Hourcade DE, Wagner LM, Oglesby TJ |
| Title | Analysis of the short consensus repeats of human complement factor B by site-directed mutagenesis. |
| Related PDB | |
| Related UniProtKB | |
| [7] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9642242 |
| Journal | J Biol Chem |
| Year | 1998 |
| Volume | 273 |
| Pages | 16828-35 |
| Authors | Rawal N, Pangburn MK |
| Title |
C5 convertase of the alternative pathway of complement. |
| Related PDB | |
| Related UniProtKB | |
| [8] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 467-764. |
| Medline ID | |
| PubMed ID | 10637221 |
| Journal | EMBO J |
| Year | 2000 |
| Volume | 19 |
| Pages | 164-73 |
| Authors | Jing H, Xu Y, Carson M, Moore D, Macon KJ, Volanakis JE, Narayana SV |
| Title | New structural motifs on the chymotrypsin fold and their potential roles in complement factor B. |
| Related PDB | 1dle |
| Related UniProtKB | P00751 |
| [9] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10617628 |
| Journal | J Biol Chem |
| Year | 2000 |
| Volume | 275 |
| Pages | 378-85 |
| Authors | Xu Y, Circolo A, Jing H, Wang Y, Narayana SV, Volanakis JE |
| Title |
Mutational analysis of the primary substrate specificity pocket of complement factor B. |
| Related PDB | |
| Related UniProtKB | |
| [10] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10640753 |
| Journal | J Immunol |
| Year | 2000 |
| Volume | 164 |
| Pages | 1379-85 |
| Authors | Rawal N, Pangburn MK |
| Title | Functional role of the noncatalytic subunit of complement C5 convertase. |
| Related PDB | |
| Related UniProtKB | |
| [11] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10966820 |
| Journal | J Mol Biol |
| Year | 2000 |
| Volume | 301 |
| Pages | 1267-85 |
| Authors | Hinshelwood J, Perkins SJ |
| Title | Conformational changes during the assembly of factor B from its domains by (1)H NMR spectroscopy and molecular modelling: their relevance to the regulation of factor B activity. |
| Related PDB | |
| Related UniProtKB | |
| [12] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11414354 |
| Journal | Immunol Rev |
| Year | 2001 |
| Volume | 180 |
| Pages | 123-35 |
| Authors | Xu Y, Narayana SV, Volanakis JE |
| Title | Structural biology of the alternative pathway convertase. |
| Related PDB | |
| Related UniProtKB | |
| [13] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11367526 |
| Journal | Int Immunopharmacol |
| Year | 2001 |
| Volume | 1 |
| Pages | 415-22 |
| Authors | Rawal N, Pangburn MK |
| Title | Structure/function of C5 convertases of complement. |
| Related PDB | |
| Related UniProtKB | |
| [14] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11160326 |
| Journal | J Immunol |
| Year | 2001 |
| Volume | 166 |
| Pages | 2635-42 |
| Authors | Rawal N, Pangburn M |
| Title | Formation of high-affinity C5 convertases of the alternative pathway of complement. |
| Related PDB | |
| Related UniProtKB | |
| [15] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12440962 |
| Journal | Biochem Soc Trans |
| Year | 2002 |
| Volume | 30 |
| Pages | 1006-10 |
| Authors | Pangburn MK, Rawal N |
| Title | Structure and function of complement C5 convertase enzymes. |
| Related PDB | |
| Related UniProtKB | |
| [16] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12475199 |
| Journal | Chem Rev |
| Year | 2002 |
| Volume | 102 |
| Pages | 4501-24 |
| Authors | Hedstrom L |
| Title | Serine protease mechanism and specificity. |
| Related PDB | |
| Related UniProtKB | |
| [17] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 15068800 |
| Journal | Mol Cell |
| Year | 2004 |
| Volume | 14 |
| Pages | 17-28 |
| Authors | Ponnuraj K, Xu Y, Macon K, Moore D, Volanakis JE, Narayana SV |
| Title | Structural analysis of engineered Bb fragment of complement factor B: insights into the activation mechanism of the alternative pathway C3-convertase. |
| Related PDB | 1rrk 1rs0 1rtk |
| Related UniProtKB | P00751 |
| [18] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 15016353 |
| Journal | Structure |
| Year | 2004 |
| Volume | 12 |
| Pages | 371-8 |
| Authors | Bhattacharya AA, Lupher ML Jr, Staunton DE, Liddington RC |
| Title | Crystal structure of the A domain from complement factor B reveals an integrin-like open conformation. |
| Related PDB | 1q0p |
| Related UniProtKB | P00751 |
| [19] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 16301317 |
| Journal | J Biol Chem |
| Year | 2006 |
| Volume | 281 |
| Pages | 2128-32 |
| Authors | Hourcade DE |
| Title | The role of properdin in the assembly of the alternative pathway C3 convertases of complement. |
| Related PDB | |
| Related UniProtKB | |
| [20] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 17310251 |
| Journal | Nat Struct Mol Biol |
| Year | 2007 |
| Volume | 14 |
| Pages | 224-8 |
| Authors | Milder FJ, Gomes L, Schouten A, Janssen BJ, Huizinga EG, Romijn RA, Hemrika W, Roos A, Daha MR, Gros P |
| Title | Factor B structure provides insights into activation of the central protease of the complement system. |
| Related PDB | 2ok5 |
| Related UniProtKB | P00751 |
| [21] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 18064050 |
| Journal | Nat Rev Immunol |
| Year | 2008 |
| Volume | 8 |
| Pages | 48-58 |
| Authors | Gros P, Milder FJ, Janssen BJ |
| Title | Complement driven by conformational changes. |
| Related PDB | |
| Related UniProtKB | |
| [22] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 19574954 |
| Journal | EMBO J |
| Year | 2009 |
| Volume | 28 |
| Pages | 2469-78 |
| Authors | Janssen BJ, Gomes L, Koning RI, Svergun DI, Koster AJ, Fritzinger DC, Vogel CW, Gros P |
| Title | Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex. |
| Related PDB | 3hrz 3hs0 |
| Related UniProtKB | P00751 Q91132 |
| [23] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 19890040 |
| Journal | J Immunol |
| Year | 2009 |
| Volume | 183 |
| Pages | 7347-51 |
| Authors | Torreira E, Tortajada A, Montes T, Rodriguez de Cordoba S, Llorca O |
| Title | Coexistence of closed and open conformations of complement factor B in the alternative pathway C3bB(Mg2+) proconvertase. |
| Related PDB | |
| Related UniProtKB | |
| [24] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 19503103 |
| Journal | Nat Immunol |
| Year | 2009 |
| Volume | 10 |
| Pages | 721-7 |
| Authors | Rooijakkers SH, Wu J, Ruyken M, van Domselaar R, Planken KL, Tzekou A, Ricklin D, Lambris JD, Janssen BJ, van Strijp JA, Gros P |
| Title | Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor. |
| Related PDB | 2win |
| Related UniProtKB | P00751 P01024 |
| [25] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 19136636 |
| Journal | Proc Natl Acad Sci U S A |
| Year | 2009 |
| Volume | 106 |
| Pages | 882-7 |
| Authors | Torreira E, Tortajada A, Montes T, Rodriguez de Cordoba S, Llorca O |
| Title | 3D structure of the C3bB complex provides insights into the activation and regulation of the complement alternative pathway convertase. |
| Related PDB | |
| Related UniProtKB | |
| [26] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 21205667 |
| Journal | Science |
| Year | 2010 |
| Volume | 330 |
| Pages | 1816-20 |
| Authors | Forneris F, Ricklin D, Wu J, Tzekou A, Wallace RS, Lambris JD, Gros P |
| Title | Structures of C3b in complex with factors B and D give insight into complement convertase formation. |
| Related PDB | 2xwb 2xwj |
| Related UniProtKB | |
| Comments |
|---|
|
This enzyme belongs to peptidase family-S1.
There are three types of activation of complement system: the classical pathway, This enzyme is composed of C-terminal fragment of complement factor B, Moreover, Since this enzyme has got the same catalytic site as trypsin, |
| Created | Updated |
|---|---|
| 2011-05-09 | 2011-08-27 |