DB code: D00197

RLCP classification 1.13.30000.10 : Hydrolysis
CATH domain 2.40.10.10 : Thrombin, subunit H Catalytic domain
2.40.10.10 : Thrombin, subunit H Catalytic domain
E.C. 3.4.21.4
CSA 1a0j
M-CSA 1a0j
MACiE

CATH domain Related DB codes (homologues)
2.40.10.10 : Thrombin, subunit H M00139 D00214 M00167 D00426 M00133 D00428 D00429 D00430 D00431 D00432 D00433 D00434 D00435 M00227 M00209 D00194 D00211 D00212 D00216 M00212 D00224 D00497 M00217 M00216 D00528 D00848 D00850 D00851 D00852 D00855 M00152 M00155 M00157 M00181 M00315 M00316 M00317 M00348 M00349 T00074 T00410 T00411

Uniprot Enzyme Name
UniprotKB Protein name Synonyms Contains MEROPS Pfam RefSeq
P00775 Trypsin
EC 3.4.21.4
SGT
None S01.101 (Serine)
PF00089 (Trypsin)
[Graphical View]
P35049 Trypsin
EC 3.4.21.4
None S01.103 (Serine)
PF00089 (Trypsin)
[Graphical View]
P35031 Trypsin-1
EC 3.4.21.4
Trypsin I
None S01.125 (Serine)
PF00089 (Trypsin)
[Graphical View]
NP_001117183.1 (Protein)
NM_001123711.1 (DNA/RNA sequence)
NP_001119704.1 (Protein)
NM_001126232.1 (DNA/RNA sequence)
P35033 Trypsin-3
EC 3.4.21.4
Trypsin III
None S01.126 (Serine)
PF00089 (Trypsin)
[Graphical View]
P00762 Anionic trypsin-1
EC 3.4.21.4
Anionic trypsin I
Pretrypsinogen I
Serine protease 1
None S01.094 (Serine)
PF00089 (Trypsin)
[Graphical View]
NP_036767.1 (Protein)
NM_012635.1 (DNA/RNA sequence)
P00763 Anionic trypsin-2
EC 3.4.21.4
Anionic trypsin II
Pretrypsinogen II
Serine protease 2
None S01.119 (Serine)
PF00089 (Trypsin)
[Graphical View]
NP_036861.1 (Protein)
NM_012729.1 (DNA/RNA sequence)
XP_003749781.1 (Protein)
XM_003749733.1 (DNA/RNA sequence)
P00761 Trypsin
EC 3.4.21.4
None PF00089 (Trypsin)
[Graphical View]
P00760 Cationic trypsin
EC 3.4.21.4
Beta-trypsin
Alpha-trypsin chain 1
Alpha-trypsin chain 2
S01.151 (Serine)
PF00089 (Trypsin)
[Graphical View]
NP_001107199.1 (Protein)
NM_001113727.1 (DNA/RNA sequence)
P07477 Trypsin-1
EC 3.4.21.4
Beta-trypsin
Cationic trypsinogen
Serine protease 1
Trypsin I
Alpha-trypsin chain 1
Alpha-trypsin chain 2
S01.127 (Serine)
PF00089 (Trypsin)
[Graphical View]
NP_002760.1 (Protein)
NM_002769.4 (DNA/RNA sequence)

KEGG enzyme name
trypsin
alpha-trypsin
beta-trypsin
cocoonase
parenzyme
parenzymol
tryptar
trypure
pseudotrypsin
tryptase
tripcellim
sperm receptor hydrolase

UniprotKB: Accession Number Entry name Activity Subunit Subcellular location Cofactor
P00775 TRYP_STRGR Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.
P35049 TRYP_FUSOX Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa. Secreted.
P35031 TRY1_SALSA Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa. Secreted, extracellular space. Binds 1 calcium ion per subunit.
P35033 TRY3_SALSA Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa. Secreted, extracellular space. Binds 1 calcium ion per subunit (By similarity).
P00762 TRY1_RAT Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa. Secreted, extracellular space. Binds 1 calcium ion per subunit.
P00763 TRY2_RAT Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa. Secreted, extracellular space. Binds 1 calcium ion per subunit.
P00761 TRYP_PIG Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa. Secreted, extracellular space. Binds 1 calcium ion per subunit.
P00760 TRY1_BOVIN Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa. Secreted, extracellular space. Binds 1 calcium ion per subunit.
P07477 TRY1_HUMAN Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa. Secreted, extracellular space. Binds 1 calcium ion per subunit.

KEGG Pathways
Map code Pathways E.C.

Compound table
Substrates Products Intermediates
KEGG-id C00012 C00001 C00012 C03253
E.C.
Compound Peptide H2O Peptide Amino acid(Arg-, Lys-)
Type peptide/protein H2O peptide/protein amino acids
ChEBI 15377
15377
PubChem 22247451
962
22247451
962
1sgtA01 Unbound Unbound Unbound Unbound
1fn8A01 Unbound Bound:GLY-ALA-ARG (chain B) Unbound Unbound
1fy4A01 Unbound Unbound Unbound Intermediate-bound:GLY-ALA-ARG (chain B)
1fy5A01 Unbound Bound:GLY-ALA-LYS (chain B) Unbound Unbound
1gdnA01 Unbound Bound:GLY-ALA-LYS (chain B) Unbound Unbound
1gdqA01 Unbound Unbound Unbound Intermediate-bound:ARG (chain B)
1gduA01 Unbound Bound:GLY-ALA-ARG (chain B) Unbound Unbound
1tryA01 Unbound Unbound Unbound Intermediate-analogue:ISP
1bitA01 Unbound Unbound Unbound Unbound
1bzxE01 Bound:LYS_515-ALA_516 (chain I) Unbound Unbound Unbound
1tbsA01 Unbound Unbound Unbound Unbound
2staE01 Bound:ARG_505-ILE_506 (chain I) Unbound Unbound Unbound
2stbE01 Bound:LYS_505-ILE_506 (chain I) Unbound Unbound Unbound
2tbsA01 Unbound Unbound Unbound Unbound
1a0jA01 Unbound Unbound Unbound Unbound
1a0jB01 Unbound Unbound Unbound Unbound
1a0jC01 Unbound Unbound Unbound Unbound
1a0jD01 Unbound Unbound Unbound Unbound
1braA01 Unbound Unbound Unbound Unbound
1brbE01 Bound:LYS_15-ALA_16 (chain I) Unbound Unbound Unbound
1brcE01 Bound:ARG_15-ALA_16 (chain I) Unbound Unbound Unbound
1trmA01 Unbound Unbound Unbound Unbound
1trmB01 Unbound Unbound Unbound Unbound
2trmA01 Unbound Unbound Unbound Unbound
1amhA01 Unbound Unbound Unbound Unbound
1amhB01 Unbound Unbound Unbound Unbound
1anbA01 Unbound Unbound Unbound Unbound
1ancA01 Unbound Unbound Unbound Unbound
1andA01 Unbound Unbound Unbound Unbound
1aneA01 Unbound Unbound Unbound Unbound
1dpoA01 Unbound Unbound Unbound Unbound
1ezsC01 Bound:ARG_284-MET_285 (chain B) Unbound Unbound Unbound
1ezsD01 Bound:ARG_84-MET_85 (chain A) Unbound Unbound Unbound
1ezuC01 Analogue:MET_284-MET_285 (chain B) Unbound Unbound Unbound
1ezuD01 Analogue:MET_84-MET_85 (chain A) Unbound Unbound Unbound
1fy8E01 Bound:LYS_15-ALA_16 (chain I) Unbound Unbound Unbound
1i99E01 Bound:LYS_353-SER_354 (chain I) Unbound Unbound Unbound
1ql9A01 Unbound Unbound Unbound Unbound
1sluB01 Analogue:MET_84-MET_85 (chain A) Unbound Unbound Unbound
1slvB01 Analogue:MET_84-MET_85 (chain A) Unbound Unbound Unbound
1slwB01 Analogue:MET_84-MET_85 (chain A) Unbound Unbound Unbound
1slxB01 Analogue:MET_84-MET_85 (chain A) Unbound Unbound Unbound
3tgiE01 Bound:LYS_15-ALA_16 (chain I) Unbound Unbound Unbound
3tgjE01 Bound:LYS_15-ALA_16 (chain I) Unbound Unbound Unbound
1aksB Unbound Unbound Unbound Unbound
1an1E01 Bound:LYS_8-ILE_9 (chain I) Unbound Unbound Unbound
1avwA01 Bound:ARG_563-ILE_564 (chain B) Unbound Unbound Unbound
1avxA01 Bound:ARG_563-ILE_564 (chain B) Unbound Unbound Unbound
1ejaA01 Bound:LYS_34-VAL_35 (chain B) Unbound Unbound Unbound
1eptC Unbound Unbound Unbound Unbound
1fmgA01 Unbound Unbound Unbound Unbound
1fn6A01 Unbound Unbound Unbound Unbound
1fniA01 Unbound Unbound Unbound Unbound
1ldtT01 Bound:LYS_8-ILE_9 (chain L) Unbound Unbound Unbound
1mctA01 Bound:ARG_5-ILE_6 (chain I) Unbound Unbound Unbound
1qquA01 Unbound Unbound Unbound Unbound
1tfxA01 Bound:ARG_15-GLY_16 (chain C) Unbound Unbound Unbound
1tfxB01 Bound:ARG_15-GLY_16 (chain D) Unbound Unbound Unbound
1aq7A01 Unbound Analogue:AEB Unbound Unbound
1aujA01 Unbound Unbound Unbound Intermediate-analogue:PPB
1az8A01 Unbound Unbound Unbound Unbound
1bjuA01 Unbound Unbound Unbound Unbound
1bjvA01 Unbound Unbound Unbound Unbound
1btpA01 Unbound Unbound Unbound Unbound
1btwA01 Unbound Unbound Unbound Intermediate-analogue:BOC-ALA-VAL-BLY (chain H)
1btxA01 Unbound Unbound Unbound Intermediate-analogue:BOC-ALA-VAL-BLY-ETH (chain H)
1btyA01 Unbound Unbound Unbound Unbound
1btzA01 Unbound Unbound Unbound Intermediate-analogue:BOC-ALA-VAL-BLY-CH3 (chain H)
1c1nA01 Unbound Unbound Unbound Unbound
1c1oA01 Unbound Unbound Unbound Unbound
1c1pA01 Unbound Unbound Unbound Unbound
1c1qA01 Unbound Unbound Unbound Unbound
1c1rA01 Unbound Unbound Unbound Unbound
1c1sA01 Unbound Unbound Unbound Unbound
1c1tA01 Unbound Unbound Unbound Unbound
1c2dA01 Unbound Unbound Unbound Unbound
1c2eA01 Unbound Unbound Unbound Unbound
1c2fA01 Unbound Unbound Unbound Unbound
1c2gA01 Unbound Unbound Unbound Unbound
1c2hA01 Unbound Unbound Unbound Unbound
1c2iA01 Unbound Unbound Unbound Unbound
1c2jA01 Unbound Unbound Unbound Unbound
1c2kA01 Unbound Unbound Unbound Unbound
1c2lA01 Unbound Unbound Unbound Unbound
1c2mA01 Unbound Unbound Unbound Unbound
1c5pA01 Unbound Unbound Unbound Unbound
1c5qA01 Unbound Unbound Unbound Unbound
1c5rA01 Unbound Unbound Unbound Unbound
1c5sA01 Unbound Unbound Unbound Unbound
1c5tA01 Unbound Unbound Unbound Unbound
1c5uA01 Unbound Unbound Unbound Unbound
1c5vA01 Unbound Unbound Unbound Unbound
1c9pA01 Bound:LYS_34-VAL_35 (chain B) Unbound Unbound Unbound
1ce5A01 Unbound Unbound Unbound Unbound
1d6rA01 Bound:LYS_16-SER_17 (chain I) Unbound Unbound Unbound
1ejmA01 Bound:ARG_515-LEU_516 (chain B) Unbound Unbound Unbound
1ejmC01 Bound:ARG_515-LEU_516 (chain D) Unbound Unbound Unbound
1ejmE01 Bound:ARG_515-LEU_516 (chain F) Unbound Unbound Unbound
1f0tA01 Unbound Unbound Unbound Unbound
1f0uA01 Unbound Unbound Unbound Unbound
1f2sE01 Bound:ARG_305-ILE_306 (chain I) Unbound Unbound Unbound
1g3bA01 Unbound Unbound Unbound Unbound
1g3cA01 Unbound Unbound Unbound Unbound
1g3dA01 Unbound Unbound Unbound Unbound
1g3eA01 Unbound Unbound Unbound Unbound
1g9iE01 Bound:LYS_311-SER_312 (chain I) Unbound Unbound Unbound
1gbtA01 Unbound Unbound Unbound Intermediate-analogue:GBS
1jrsA01 Unbound Unbound Unbound Intermediate-bound:ACE-LEU-LEU-ARG (chain B)
1jrtA01 Unbound Unbound Unbound Intermediate-bound:ACE-LEU-LEU-ARG (chain B)
1maxA01 Unbound Unbound Unbound Intermediate-analogue:ZAP
1mayA01 Unbound Unbound Unbound Intermediate-analogue:ZAP
1mcuE01 Bound:ARG_305-ILE_306 (chain I) Unbound Unbound Unbound
1mtsA01 Unbound Unbound Unbound Unbound
1mtuA01 Unbound Unbound Unbound Unbound
1mtvA01 Unbound Unbound Unbound Unbound
1mtwA01 Unbound Unbound Unbound Unbound
1ntpA01 Unbound Unbound Unbound Intermediate-analogue:MIP
1ppcE01 Unbound Analogue:NAS-GLY-APH-PIP (chain I) Unbound Unbound
1ppeE01 Bound:ARG_5-ILE_6 (chain I) Unbound Unbound Unbound
1pphE01 Unbound Analogue:TOS-APM-PIP (chain I) Unbound Unbound
1qa0A01 Unbound Unbound Unbound Unbound
1qb1A01 Unbound Unbound Unbound Unbound
1qb6A01 Unbound Unbound Unbound Unbound
1qb9A01 Unbound Unbound Unbound Unbound
1qbnA01 Unbound Unbound Unbound Unbound
1qboA01 Unbound Unbound Unbound Unbound
1ql7A01 Unbound Unbound Unbound Unbound
1ql8A01 Unbound Unbound Unbound Unbound
1sbwA01 Bound:LYS_20-SER_21 (chain I) Unbound Unbound Unbound
1sfiA01 Bound:LYS_5-SER_6 (chain I) Unbound Unbound Unbound
1smfE01 Bound:LYS_11-SER_12 (chain I) Unbound Unbound Unbound
1tabE01 Bound:LYS_26-SER_27 (chain I) Unbound Unbound Unbound
1tawA01 Bound:ARG_15-ALA_16 (chain B) Unbound Unbound Unbound
1tgbA01 Unbound Unbound Unbound Unbound
1tgcA01 Unbound Unbound Unbound Unbound
1tgnA01 Unbound Unbound Unbound Unbound
1tgsZ01 Bound:LYS_18-ILE_19 (chain I) Unbound Unbound Unbound
1tgtA01 Unbound Unbound Unbound Unbound
1tioA01 Unbound Unbound Unbound Unbound
1tldA01 Unbound Unbound Unbound Unbound
1tngA01 Unbound Unbound Unbound Unbound
1tnhA01 Unbound Unbound Unbound Unbound
1tniA01 Unbound Unbound Unbound Unbound
1tnjA01 Unbound Unbound Unbound Unbound
1tnkA01 Unbound Unbound Unbound Unbound
1tnlA01 Unbound Unbound Unbound Unbound
1tpaE01 Bound:LYS_15-ALA_16 (chain I) Unbound Unbound Unbound
1tpoA01 Unbound Unbound Unbound Unbound
1tppA01 Unbound Unbound Unbound Intermediate-analogue:APA
1tpsA01 Analogue:A9A Unbound Unbound Unbound
1tynA01 Unbound Unbound Unbound Intermediate-analogue:CTA
1xufA01 Unbound Unbound Unbound Unbound
1xugA01 Unbound Unbound Unbound Unbound
1xuhA01 Unbound Unbound Unbound Unbound
1xuiA01 Unbound Unbound Unbound Unbound
1xujA01 Unbound Unbound Unbound Unbound
1xukA01 Unbound Unbound Unbound Unbound
1yyy101 Unbound Unbound Unbound Intermediate-analogue:BNS-NVA-GLY-3GA
2btcE01 Bound:LYS_505-ILE_506 (chain I) Unbound Unbound Unbound
2bzaA01 Unbound Unbound Unbound Unbound
2ptcE01 Bound:LYS_15-ALA_16 (chain I) Unbound Unbound Unbound
2ptnA01 Unbound Unbound Unbound Unbound
2tgaA01 Unbound Unbound Unbound Unbound
2tgdA01 Unbound Unbound Unbound Intermediate-analogue:DFP
2tgpZ01 Bound:LYS_15-ALA_16 (chain I) Unbound Unbound Unbound
2tgtA01 Unbound Unbound Unbound Unbound
2tioA01 Unbound Unbound Unbound Unbound
2tpiZ01 Bound:LYS_15-ALA_16 (chain I) Unbound Unbound Unbound
3btdE01 Analogue:ASP_515-ALA_516 (chain I) Unbound Unbound Unbound
3bteE01 Analogue:GLU_515-ALA_516 (chain I) Unbound Unbound Unbound
3btfE01 Analogue:PHE_515-ALA_516 (chain I) Unbound Unbound Unbound
3btgE01 Analogue:GLY_515-ALA_516 (chain I) Unbound Unbound Unbound
3bthE01 Analogue:HIS_515-ALA_516 (chain I) Unbound Unbound Unbound
3btkE01 Bound:LYS_515-ALA_516 (chain I) Unbound Unbound Unbound
3btmE01 Analogue:MET_515-ALA_516 (chain I) Unbound Unbound Unbound
3btqE01 Analogue:GLN_515-ALA_516 (chain I) Unbound Unbound Unbound
3bttE01 Analogue:THR_515-ALA_516 (chain I) Unbound Unbound Unbound
3btwE01 Analogue:TRP_515-ALA_516 (chain I) Unbound Unbound Unbound
3ptbA01 Unbound Unbound Unbound Unbound
3ptnA01 Unbound Unbound Unbound Unbound
3tpiZ01 Bound:LYS_15-ALA_16 (chain I) Unbound Unbound Unbound
4ptpA01 Unbound Unbound Unbound Intermediate-analogue:DIP
4tpiZ01 Bound:ARG_15-ALA_16 (chain I) Unbound Unbound Unbound
5ptpA01 Unbound Unbound Unbound Intermediate-analogue:MIS
1ezxC01 Unbound Bound:SER_359 (chain B) Unbound Intermediate-bound:MET_358 (chain A)
1trnA01 Unbound Unbound Unbound Intermediate-analogue:ISP
1trnB01 Unbound Unbound Unbound Intermediate-analogue:ISP
1sgtA02 Unbound Unbound Unbound Unbound
1fn8A02 Unbound Unbound Unbound Unbound
1fy4A02 Unbound Unbound Unbound Unbound
1fy5A02 Unbound Unbound Unbound Unbound
1gdnA02 Unbound Unbound Unbound Unbound
1gdqA02 Unbound Unbound Unbound Unbound
1gduA02 Unbound Unbound Unbound Unbound
1tryA02 Unbound Unbound Unbound Unbound
1bitA02 Unbound Unbound Unbound Unbound
1bzxE02 Unbound Unbound Unbound Unbound
1tbsA02 Unbound Unbound Unbound Unbound
2staE02 Unbound Unbound Unbound Unbound
2stbE02 Unbound Unbound Unbound Unbound
2tbsA02 Unbound Unbound Unbound Unbound
1a0jA02 Unbound Unbound Unbound Unbound
1a0jB02 Unbound Unbound Unbound Unbound
1a0jC02 Unbound Unbound Unbound Unbound
1a0jD02 Unbound Unbound Unbound Unbound
1braA02 Unbound Unbound Unbound Unbound
1brbE02 Unbound Unbound Unbound Unbound
1brcE02 Unbound Unbound Unbound Unbound
1trmA02 Unbound Unbound Unbound Unbound
1trmB02 Unbound Unbound Unbound Unbound
2trmA02 Unbound Unbound Unbound Unbound
1amhA02 Unbound Unbound Unbound Unbound
1amhB02 Unbound Unbound Unbound Unbound
1anbA02 Unbound Unbound Unbound Unbound
1ancA02 Unbound Unbound Unbound Unbound
1andA02 Unbound Unbound Unbound Unbound
1aneA02 Unbound Unbound Unbound Unbound
1dpoA02 Unbound Unbound Unbound Unbound
1ezsC02 Unbound Unbound Unbound Unbound
1ezsD02 Unbound Unbound Unbound Unbound
1ezuC02 Unbound Unbound Unbound Unbound
1ezuD02 Unbound Unbound Unbound Unbound
1fy8E02 Unbound Unbound Unbound Unbound
1i99E02 Unbound Unbound Unbound Unbound
1ql9A02 Unbound Unbound Unbound Unbound
1sluB02 Unbound Unbound Unbound Unbound
1slvB02 Unbound Unbound Unbound Unbound
1slwB02 Unbound Unbound Unbound Unbound
1slxB02 Unbound Unbound Unbound Unbound
3tgiE02 Unbound Unbound Unbound Unbound
3tgjE02 Unbound Unbound Unbound Unbound
1aksA Unbound Unbound Unbound Unbound
1an1E02 Unbound Unbound Unbound Unbound
1avwA02 Unbound Unbound Unbound Unbound
1avxA02 Unbound Unbound Unbound Unbound
1ejaA02 Unbound Unbound Unbound Unbound
1eptA Unbound Unbound Unbound Unbound
1eptB Unbound Unbound Unbound Unbound
1fmgA02 Unbound Unbound Unbound Unbound
1fn6A02 Unbound Unbound Unbound Unbound
1fniA02 Unbound Unbound Unbound Unbound
1ldtT02 Unbound Unbound Unbound Unbound
1mctA02 Unbound Unbound Unbound Unbound
1qquA02 Unbound Unbound Unbound Unbound
1tfxA02 Unbound Unbound Unbound Unbound
1tfxB02 Unbound Unbound Unbound Unbound
1aq7A02 Unbound Unbound Unbound Unbound
1aujA02 Unbound Unbound Unbound Unbound
1az8A02 Unbound Unbound Unbound Unbound
1bjuA02 Unbound Unbound Unbound Unbound
1bjvA02 Unbound Unbound Unbound Unbound
1btpA02 Unbound Unbound Unbound Unbound
1btwA02 Unbound Unbound Unbound Unbound
1btxA02 Unbound Unbound Unbound Unbound
1btyA02 Unbound Unbound Unbound Unbound
1btzA02 Unbound Unbound Unbound Unbound
1c1nA02 Unbound Unbound Unbound Unbound
1c1oA02 Unbound Unbound Unbound Unbound
1c1pA02 Unbound Unbound Unbound Unbound
1c1qA02 Unbound Unbound Unbound Unbound
1c1rA02 Unbound Unbound Unbound Unbound
1c1sA02 Unbound Unbound Unbound Unbound
1c1tA02 Unbound Unbound Unbound Unbound
1c2dA02 Unbound Unbound Unbound Unbound
1c2eA02 Unbound Unbound Unbound Unbound
1c2fA02 Unbound Unbound Unbound Unbound
1c2gA02 Unbound Unbound Unbound Unbound
1c2hA02 Unbound Unbound Unbound Unbound
1c2iA02 Unbound Unbound Unbound Unbound
1c2jA02 Unbound Unbound Unbound Unbound
1c2kA02 Unbound Unbound Unbound Unbound
1c2lA02 Unbound Unbound Unbound Unbound
1c2mA02 Unbound Unbound Unbound Unbound
1c5pA02 Unbound Unbound Unbound Unbound
1c5qA02 Unbound Unbound Unbound Unbound
1c5rA02 Unbound Unbound Unbound Unbound
1c5sA02 Unbound Unbound Unbound Unbound
1c5tA02 Unbound Unbound Unbound Unbound
1c5uA02 Unbound Unbound Unbound Unbound
1c5vA02 Unbound Unbound Unbound Unbound
1c9pA02 Unbound Unbound Unbound Unbound
1ce5A02 Unbound Unbound Unbound Unbound
1d6rA02 Unbound Unbound Unbound Unbound
1ejmA02 Unbound Unbound Unbound Unbound
1ejmC02 Unbound Unbound Unbound Unbound
1ejmE02 Unbound Unbound Unbound Unbound
1f0tA02 Unbound Unbound Unbound Unbound
1f0uA02 Unbound Unbound Unbound Unbound
1f2sE02 Unbound Unbound Unbound Unbound
1g3bA02 Unbound Unbound Unbound Unbound
1g3cA02 Unbound Unbound Unbound Unbound
1g3dA02 Unbound Unbound Unbound Unbound
1g3eA02 Unbound Unbound Unbound Unbound
1g9iE02 Unbound Unbound Unbound Unbound
1gbtA02 Unbound Unbound Unbound Unbound
1jrsA02 Unbound Unbound Unbound Unbound
1jrtA02 Unbound Unbound Unbound Unbound
1maxA02 Unbound Unbound Unbound Unbound
1mayA02 Unbound Unbound Unbound Unbound
1mcuE02 Unbound Unbound Unbound Unbound
1mtsA02 Unbound Unbound Unbound Unbound
1mtuA02 Unbound Unbound Unbound Unbound
1mtvA02 Unbound Unbound Unbound Unbound
1mtwA02 Unbound Unbound Unbound Unbound
1ntpA02 Unbound Unbound Unbound Unbound
1ppcE02 Unbound Unbound Unbound Unbound
1ppeE02 Unbound Unbound Unbound Unbound
1pphE02 Unbound Unbound Unbound Unbound
1qa0A02 Unbound Unbound Unbound Unbound
1qb1A02 Unbound Unbound Unbound Unbound
1qb6A02 Unbound Unbound Unbound Unbound
1qb9A02 Unbound Unbound Unbound Unbound
1qbnA02 Unbound Unbound Unbound Unbound
1qboA02 Unbound Unbound Unbound Unbound
1ql7A02 Unbound Unbound Unbound Unbound
1ql8A02 Unbound Unbound Unbound Unbound
1sbwA02 Unbound Unbound Unbound Unbound
1sfiA02 Unbound Unbound Unbound Unbound
1smfE02 Unbound Unbound Unbound Unbound
1tabE02 Unbound Unbound Unbound Unbound
1tawA02 Unbound Unbound Unbound Unbound
1tgbA02 Unbound Unbound Unbound Unbound
1tgcA02 Unbound Unbound Unbound Unbound
1tgnA02 Unbound Unbound Unbound Unbound
1tgsZ02 Unbound Unbound Unbound Unbound
1tgtA02 Unbound Unbound Unbound Unbound
1tioA02 Unbound Unbound Unbound Unbound
1tldA02 Unbound Unbound Unbound Unbound
1tngA02 Unbound Unbound Unbound Unbound
1tnhA02 Unbound Unbound Unbound Unbound
1tniA02 Unbound Unbound Unbound Unbound
1tnjA02 Unbound Unbound Unbound Unbound
1tnkA02 Unbound Unbound Unbound Unbound
1tnlA02 Unbound Unbound Unbound Unbound
1tpaE02 Unbound Unbound Unbound Unbound
1tpoA02 Unbound Unbound Unbound Unbound
1tppA02 Unbound Unbound Unbound Unbound
1tpsA02 Unbound Unbound Unbound Unbound
1tynA02 Unbound Unbound Unbound Unbound
1xufA02 Unbound Unbound Unbound Unbound
1xugA02 Unbound Unbound Unbound Unbound
1xuhA02 Unbound Unbound Unbound Unbound
1xuiA02 Unbound Unbound Unbound Unbound
1xujA02 Unbound Unbound Unbound Unbound
1xukA02 Unbound Unbound Unbound Unbound
1yyy102 Unbound Unbound Unbound Unbound
2btcE02 Unbound Unbound Unbound Unbound
2bzaA02 Unbound Unbound Unbound Unbound
2ptcE02 Unbound Unbound Unbound Unbound
2ptnA02 Unbound Unbound Unbound Unbound
2tgaA02 Unbound Unbound Unbound Unbound
2tgdA02 Unbound Unbound Unbound Unbound
2tgpZ02 Unbound Unbound Unbound Unbound
2tgtA02 Unbound Unbound Unbound Unbound
2tioA02 Unbound Unbound Unbound Unbound
2tpiZ02 Unbound Unbound Unbound Unbound
3btdE02 Unbound Unbound Unbound Unbound
3bteE02 Unbound Unbound Unbound Unbound
3btfE02 Unbound Unbound Unbound Unbound
3btgE02 Unbound Unbound Unbound Unbound
3bthE02 Unbound Unbound Unbound Unbound
3btkE02 Unbound Unbound Unbound Unbound
3btmE02 Unbound Unbound Unbound Unbound
3btqE02 Unbound Unbound Unbound Unbound
3bttE02 Unbound Unbound Unbound Unbound
3btwE02 Unbound Unbound Unbound Unbound
3ptbA02 Unbound Unbound Unbound Unbound
3ptnA02 Unbound Unbound Unbound Unbound
3tpiZ02 Unbound Unbound Unbound Unbound
4ptpA02 Unbound Unbound Unbound Unbound
4tpiZ02 Unbound Unbound Unbound Unbound
5ptpA02 Unbound Unbound Unbound Unbound
1ezxC02 Unbound Unbound Unbound Unbound
1trnA02 Unbound Unbound Unbound Unbound
1trnB02 Unbound Unbound Unbound Unbound

Reference for Active-site residues
resource references E.C.

Active-site residues
PDB Catalytic residues Cofactor-binding residues Modified residues Main-chain involved in catalysis Comment
1sgtA01 SER 195 GLY 193;SER 195
1fn8A01 SER 195 GLY 193;SER 195
1fy4A01 SER 195 GLY 193;SER 195
1fy5A01 SER 195 GLY 193;SER 195
1gdnA01 SER 195 GLY 193;SER 195
1gdqA01 SER 195 GLY 193;SER 195
1gduA01 SER 195 GLY 193;SER 195
1tryA01 SER 195 GLY 193;SER 195
1bitA01 SER 195 GLY 193;SER 195
1bzxE01 SER 195 GLY 193;SER 195
1tbsA01 SER 195 GLY 193;SER 195
2staE01 SER 195 GLY 193;SER 195
2stbE01 SER 195 GLY 193;SER 195
2tbsA01 SER 195 GLY 193;SER 195
1a0jA01 SER 195 GLY 193;SER 195
1a0jB01 SER 195 GLY 193;SER 195
1a0jC01 SER 195 GLY 193;SER 195
1a0jD01 SER 195 GLY 193;SER 195
1braA01 SER 195 GLY 193;SER 195 mutant D189G, G226D
1brbE01 SER 195 GLY 193;SER 195 mutant D189G, G226D
1brcE01 SER 195 GLY 193;SER 195 mutant D189G, G226D
1trmA01 SER 195 GLY 193;SER 195
1trmB01 SER 195 GLY 193;SER 195
2trmA01 SER 195 GLY 193;SER 195
1amhA01 SER 195 GLY 193;SER 195 mutant D189S
1amhB01 SER 195 GLY 193;SER 195 mutant D189S
1anbA01 SER 195 GLY 193;SER 195 mutant S214E
1ancA01 SER 195 GLY 193;SER 195 mutant S214K
1andA01 SER 195 GLY 193;SER 195
1aneA01 SER 195 GLY 193;SER 195
1dpoA01 GLY 193; mutant S195C
1ezsC01 SER 595 GLY 593;SER 595
1ezsD01 SER 895 GLY 893;SER 895
1ezuC01 SER 595 GLY 593;SER 595
1ezuD01 SER 895 GLY 893;SER 895
1fy8E01 SER 195 GLY 193;SER 195
1i99E01 GLY 193; mutant S195A
1ql9A01 SER 195 GLY 193;SER 195
1sluB01 SER 195 GLY 193;SER 195 mutant N143H, E151H
1slvB01 SER 195 GLY 193;SER 195 mutant N143H, E151H
1slwB01 SER 195 GLY 193;SER 195 mutant V121I, N143H, E151H
1slxB01 SER 195 GLY 193;SER 195 mutant N143H, E151H
3tgiE01 SER 195 GLY 193;SER 195
3tgjE01 GLY 193; mutant S195A
1aksB SER 195 GLY 193;SER 195
1an1E01 SER 195 GLY 193;SER 195
1avwA01 SER 195 GLY 193;SER 195
1avxA01 SER 195 GLY 193;SER 195
1ejaA01 SER 195 GLY 193;SER 195
1eptC SER 195 GLY 193;SER 195
1fmgA01 SER 195 GLY 193;SER 195
1fn6A01 SER 195 GLY 193;SER 195
1fniA01 SER 195 GLY 193;SER 195
1ldtT01 SER 195 GLY 193;SER 195
1mctA01 SER 195 GLY 193;SER 195
1qquA01 SER 195 GLY 193;SER 195
1tfxA01 SER 195 GLY 193;SER 195
1tfxB01 SER 195 GLY 193;SER 195
1aq7A01 SER 195 GLY 193;SER 195
1aujA01 SER 195 GLY 193;SER 195
1az8A01 SER 195 GLY 193;SER 195
1bjuA01 SER 195 GLY 193;SER 195
1bjvA01 SER 195 GLY 193;SER 195
1btpA01 SER 195 GLY 193;SER 195
1btwA01 SER 195 GLY 193;SER 195
1btxA01 SER 195 GLY 193;SER 195
1btyA01 SER 195 GLY 193;SER 195
1btzA01 SER 195 GLY 193;SER 195
1c1nA01 SER 195 GLY 193;SER 195
1c1oA01 SER 195 GLY 193;SER 195
1c1pA01 SER 195 GLY 193;SER 195
1c1qA01 SER 195 GLY 193;SER 195
1c1rA01 SER 195 GLY 193;SER 195
1c1sA01 SER 195 GLY 193;SER 195
1c1tA01 SER 195 GLY 193;SER 195
1c2dA01 SER 195 GLY 193;SER 195
1c2eA01 SER 195 GLY 193;SER 195
1c2fA01 SER 195 GLY 193;SER 195
1c2gA01 SER 195 GLY 193;SER 195
1c2hA01 SER 195 GLY 193;SER 195
1c2iA01 SER 195 GLY 193;SER 195
1c2jA01 SER 195 GLY 193;SER 195
1c2kA01 SER 195 GLY 193;SER 195
1c2lA01 SER 195 GLY 193;SER 195
1c2mA01 SER 195 GLY 193;SER 195
1c5pA01 SER 195 GLY 193;SER 195
1c5qA01 SER 195 GLY 193;SER 195
1c5rA01 SER 195 GLY 193;SER 195
1c5sA01 SER 195 GLY 193;SER 195
1c5tA01 SER 195 GLY 193;SER 195
1c5uA01 SER 195 GLY 193;SER 195
1c5vA01 SER 195 GLY 193;SER 195
1c9pA01 SER 195 GLY 193;SER 195
1ce5A01 SER 195 GLY 193;SER 195
1d6rA01 SER 195 GLY 193;SER 195
1ejmA01 SER 195 GLY 193;SER 195 mutant A16L
1ejmC01 SER 195 GLY 193;SER 195 mutant A16L
1ejmE01 SER 195 GLY 193;SER 195 mutant A16L
1f0tA01 SER 195 GLY 193;SER 195
1f0uA01 SER 195 GLY 193;SER 195
1f2sE01 SER 195 GLY 193;SER 195
1g3bA01 SER 195 GLY 193;SER 195
1g3cA01 SER 195 GLY 193;SER 195
1g3dA01 SER 195 GLY 193;SER 195
1g3eA01 SER 195 GLY 193;SER 195
1g9iE01 SER 195 GLY 193;SER 195
1gbtA01 SER 195 GLY 193;SER 195
1jrsA01 SER 195 GLY 193;SER 195
1jrtA01 SER 195 GLY 193;SER 195
1maxA01 SER 195 GLY 193;SER 195
1mayA01 SER 195 GLY 193;SER 195
1mcuE01 SER 195 GLY 193;SER 195
1mtsA01 SER 195 GLY 193;SER 195
1mtuA01 SER 195 GLY 193;SER 195
1mtvA01 SER 195 GLY 193;SER 195
1mtwA01 SER 195 GLY 193;SER 195
1ntpA01 SER 195 GLY 193;SER 195
1ppcE01 SER 195 GLY 193;SER 195
1ppeE01 SER 195 GLY 193;SER 195
1pphE01 SER 195 GLY 193;SER 195
1qa0A01 SER 183 GLY 181;SER 183
1qb1A01 SER 183 GLY 181;SER 183
1qb6A01 SER 183 GLY 181;SER 183
1qb9A01 SER 183 GLY 181;SER 183
1qbnA01 SER 183 GLY 181;SER 183
1qboA01 SER 183 GLY 181;SER 183
1ql7A01 SER 195 GLY 193;SER 195
1ql8A01 SER 195 GLY 193;SER 195
1sbwA01 SER 195 GLY 193;SER 195
1sfiA01 SER 195 GLY 193;SER 195
1smfE01 SER 195 GLY 193;SER 195
1tabE01 SER 195 GLY 193;SER 195
1tawA01 SER 195 GLY 193;SER 195
1tgbA01 SER 195 GLY 193;SER 195
1tgcA01 SER 195 GLY 193;SER 195
1tgnA01 SER 195 GLY 193;SER 195
1tgsZ01 SER 195 GLY 193;SER 195
1tgtA01 SER 195 GLY 193;SER 195
1tioA01 SER 195 GLY 193;SER 195
1tldA01 SER 195 GLY 193;SER 195
1tngA01 SER 195 GLY 193;SER 195
1tnhA01 SER 195 GLY 193;SER 195
1tniA01 SER 195 GLY 193;SER 195
1tnjA01 SER 195 GLY 193;SER 195
1tnkA01 SER 195 GLY 193;SER 195
1tnlA01 SER 195 GLY 193;SER 195
1tpaE01 SER 195 GLY 193;SER 195
1tpoA01 SER 195 GLY 193;SER 195
1tppA01 SER 195 GLY 193;SER 195
1tpsA01 SER 195 GLY 193;SER 195
1tynA01 SER 195 GLY 193;SER 195
1xufA01 SER 195 GLY 193;SER 195
1xugA01 SER 195 GLY 193;SER 195
1xuhA01 SER 195 GLY 193;SER 195
1xuiA01 SER 195 GLY 193;SER 195
1xujA01 SER 195 GLY 193;SER 195
1xukA01 SER 195 GLY 193;SER 195
1yyy101 SER 195 GLY 193;SER 195
2btcE01 SER 195 GLY 193;SER 195
2bzaA01 SER 195 GLY 193;SER 195
2ptcE01 SER 195 GLY 193;SER 195
2ptnA01 SER 195 GLY 193;SER 195
2tgaA01 SER 195 GLY 193;SER 195
2tgdA01 SER 195 GLY 193;SER 195
2tgpZ01 SER 195 GLY 193;SER 195
2tgtA01 SER 195 GLY 193;SER 195
2tioA01 SER 195 GLY 193;SER 195
2tpiZ01 SER 195 GLY 193;SER 195
3btdE01 SER 195 GLY 193;SER 195
3bteE01 SER 195 GLY 193;SER 195
3btfE01 SER 195 GLY 193;SER 195
3btgE01 SER 195 GLY 193;SER 195
3bthE01 SER 195 GLY 193;SER 195
3btkE01 SER 195 GLY 193;SER 195
3btmE01 SER 195 GLY 193;SER 195
3btqE01 SER 195 GLY 193;SER 195
3bttE01 SER 195 GLY 193;SER 195
3btwE01 SER 195 GLY 193;SER 195
3ptbA01 SER 195 GLY 193;SER 195
3ptnA01 SER 195 GLY 193;SER 195
3tpiZ01 SER 195 GLY 193;SER 195
4ptpA01 SER 195 GLY 193;SER 195
4tpiZ01 SER 195 GLY 193;SER 195
5ptpA01 MIS 195(monoisopropyl-phosphorylated) GLY 193;MIS 195
1ezxC01 SER 195 GLY 193;SER 195
1trnA01 SER 195 GLY 193;SER 195
1trnB01 SER 195 GLY 193;SER 195
1sgtA02 HIS 57;ASP 102
1fn8A02 HIS 57;ASP 102
1fy4A02 HIS 57;ASP 102
1fy5A02 HIS 57;ASP 102
1gdnA02 HIS 57;ASP 102
1gdqA02 HIS 57;ASP 102
1gduA02 HIS 57;ASP 102
1tryA02 HIS 57;ASP 102
1bitA02 HIS 57;ASP 102
1bzxE02 HIS 57;ASP 102
1tbsA02 HIS 57;ASP 102
2staE02 HIS 57;ASP 102
2stbE02 HIS 57;ASP 102
2tbsA02 HIS 57;ASP 102
1a0jA02 HIS 57;ASP 102
1a0jB02 HIS 57;ASP 102
1a0jC02 HIS 57;ASP 102
1a0jD02 HIS 57;ASP 102
1braA02 HIS 57;ASP 102
1brbE02 HIS 57;ASP 102
1brcE02 HIS 57;ASP 102
1trmA02 HIS 57; mutant D102N
1trmB02 HIS 57; mutant D102N
2trmA02 HIS 57; mutant D102N
1amhA02 HIS 57;ASP 102
1amhB02 HIS 57;ASP 102
1anbA02 HIS 57;ASP 102
1ancA02 HIS 57;ASP 102
1andA02 HIS 57;ASP 102 mutant R96H
1aneA02 HIS 57;ASP 102
1dpoA02 HIS 57;ASP 102
1ezsC02 HIS 457; mutant D502N
1ezsD02 HIS 757; mutant D802N
1ezuC02 HIS 457; mutant D502N
1ezuD02 HIS 757; mutant D802N
1fy8E02 HIS 57;ASP 102
1i99E02 HIS 57;ASP 102
1ql9A02 HIS 57;ASP 102
1sluB02 HIS 57;ASP 102
1slvB02 HIS 57;ASP 102
1slwB02 HIS 57;ASP 102
1slxB02 HIS 57;ASP 102
3tgiE02 HIS 57;ASP 102
3tgjE02 HIS 57;ASP 102
1aksA HIS 57;ASP 102
1an1E02 HIS 57;ASP 102
1avwA02 HIS 57;ASP 102
1avxA02 HIS 57;ASP 102
1ejaA02 HIS 57;ASP 102
1eptA HIS 57;
1eptB ;ASP 102
1fmgA02 HIS 57;ASP 102
1fn6A02 HIS 57;ASP 102
1fniA02 HIS 57;ASP 102
1ldtT02 HIS 57;ASP 102
1mctA02 HIS 57;ASP 102
1qquA02 HIS 57;ASP 102
1tfxA02 HIS 57;ASP 102
1tfxB02 HIS 57;ASP 102
1aq7A02 HIS 57;ASP 102
1aujA02 HIS 57;ASP 102
1az8A02 HIS 57;ASP 102
1bjuA02 HIS 57;ASP 102
1bjvA02 HIS 57;ASP 102
1btpA02 HIS 57;ASP 102
1btwA02 HIS 57;ASP 102
1btxA02 HIS 57;ASP 102
1btyA02 HIS 57;ASP 102
1btzA02 HIS 57;ASP 102
1c1nA02 HIS 57;ASP 102
1c1oA02 HIS 57;ASP 102
1c1pA02 HIS 57;ASP 102
1c1qA02 HIS 57;ASP 102
1c1rA02 HIS 57;ASP 102
1c1sA02 HIS 57;ASP 102
1c1tA02 HIS 57;ASP 102
1c2dA02 HIS 57;ASP 102
1c2eA02 HIS 57;ASP 102
1c2fA02 HIS 57;ASP 102
1c2gA02 HIS 57;ASP 102
1c2hA02 HIS 57;ASP 102
1c2iA02 HIS 57;ASP 102
1c2jA02 HIS 57;ASP 102
1c2kA02 HIS 57;ASP 102
1c2lA02 HIS 57;ASP 102
1c2mA02 HIS 57;ASP 102
1c5pA02 HIS 57;ASP 102
1c5qA02 HIS 57;ASP 102
1c5rA02