DB code: D00197

RLCP classification	1.13.30000.10 : Hydrolysis
CATH domain	2.40.10.10 : Thrombin, subunit H	Catalytic domain
	2.40.10.10 : Thrombin, subunit H	Catalytic domain
E.C.	3.4.21.4
CSA	1a0j
M-CSA	1a0j
MACiE

CATH domain	Related DB codes (homologues)
2.40.10.10 : Thrombin, subunit H	M00139 D00214 M00167 D00426 M00133 D00428 D00429 D00430 D00431 D00432 D00433 D00434 D00435 M00227 M00209 D00194 D00211 D00212 D00216 M00212 D00224 D00497 M00217 M00216 D00528 D00848 D00850 D00851 D00852 D00855 M00152 M00155 M00157 M00181 M00315 M00316 M00317 M00348 M00349 T00074 T00410 T00411

Uniprot Enzyme Name
UniprotKB	Protein name	Synonyms	Contains	MEROPS	Pfam	RefSeq
P00775	Trypsin	EC 3.4.21.4 SGT	None	S01.101 (Serine)	PF00089 (Trypsin) [Graphical View]
P35049	Trypsin	EC 3.4.21.4	None	S01.103 (Serine)	PF00089 (Trypsin) [Graphical View]
P35031	Trypsin-1	EC 3.4.21.4 Trypsin I	None	S01.125 (Serine)	PF00089 (Trypsin) [Graphical View]	NP_001117183.1 (Protein) NM_001123711.1 (DNA/RNA sequence) NP_001119704.1 (Protein) NM_001126232.1 (DNA/RNA sequence)
P35033	Trypsin-3	EC 3.4.21.4 Trypsin III	None	S01.126 (Serine)	PF00089 (Trypsin) [Graphical View]
P00762	Anionic trypsin-1	EC 3.4.21.4 Anionic trypsin I Pretrypsinogen I Serine protease 1	None	S01.094 (Serine)	PF00089 (Trypsin) [Graphical View]	NP_036767.1 (Protein) NM_012635.1 (DNA/RNA sequence)
P00763	Anionic trypsin-2	EC 3.4.21.4 Anionic trypsin II Pretrypsinogen II Serine protease 2	None	S01.119 (Serine)	PF00089 (Trypsin) [Graphical View]	NP_036861.1 (Protein) NM_012729.1 (DNA/RNA sequence) XP_003749781.1 (Protein) XM_003749733.1 (DNA/RNA sequence)
P00761	Trypsin	EC 3.4.21.4	None		PF00089 (Trypsin) [Graphical View]
P00760	Cationic trypsin	EC 3.4.21.4 Beta-trypsin	Alpha-trypsin chain 1 Alpha-trypsin chain 2	S01.151 (Serine)	PF00089 (Trypsin) [Graphical View]	NP_001107199.1 (Protein) NM_001113727.1 (DNA/RNA sequence)
P07477	Trypsin-1	EC 3.4.21.4 Beta-trypsin Cationic trypsinogen Serine protease 1 Trypsin I	Alpha-trypsin chain 1 Alpha-trypsin chain 2	S01.127 (Serine)	PF00089 (Trypsin) [Graphical View]	NP_002760.1 (Protein) NM_002769.4 (DNA/RNA sequence)

KEGG enzyme name
trypsin alpha-trypsin beta-trypsin cocoonase parenzyme parenzymol tryptar trypure pseudotrypsin tryptase tripcellim sperm receptor hydrolase

UniprotKB: Accession Number	Entry name	Activity	Subunit	Subcellular location	Cofactor
P00775	TRYP_STRGR	Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.
P35049	TRYP_FUSOX	Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.		Secreted.
P35031	TRY1_SALSA	Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.		Secreted, extracellular space.	Binds 1 calcium ion per subunit.
P35033	TRY3_SALSA	Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.		Secreted, extracellular space.	Binds 1 calcium ion per subunit (By similarity).
P00762	TRY1_RAT	Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.		Secreted, extracellular space.	Binds 1 calcium ion per subunit.
P00763	TRY2_RAT	Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.		Secreted, extracellular space.	Binds 1 calcium ion per subunit.
P00761	TRYP_PIG	Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.		Secreted, extracellular space.	Binds 1 calcium ion per subunit.
P00760	TRY1_BOVIN	Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.		Secreted, extracellular space.	Binds 1 calcium ion per subunit.
P07477	TRY1_HUMAN	Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.		Secreted, extracellular space.	Binds 1 calcium ion per subunit.

KEGG Pathways
Map code	Pathways	E.C.

Compound table
						Substrates		Products		Intermediates
KEGG-id						C00012	C00001	C00012	C03253
E.C.
Compound						Peptide	H2O	Peptide	Amino acid(Arg-, Lys-)
Type						peptide/protein	H2O	peptide/protein	amino acids
ChEBI							15377 15377
PubChem							22247451 962 22247451 962
1sgtA01						Unbound		Unbound	Unbound	Unbound
1fn8A01						Unbound		Bound:GLY-ALA-ARG (chain B)	Unbound	Unbound
1fy4A01						Unbound		Unbound	Unbound	Intermediate-bound:GLY-ALA-ARG (chain B)
1fy5A01						Unbound		Bound:GLY-ALA-LYS (chain B)	Unbound	Unbound
1gdnA01						Unbound		Bound:GLY-ALA-LYS (chain B)	Unbound	Unbound
1gdqA01						Unbound		Unbound	Unbound	Intermediate-bound:ARG (chain B)
1gduA01						Unbound		Bound:GLY-ALA-ARG (chain B)	Unbound	Unbound
1tryA01						Unbound		Unbound	Unbound	Intermediate-analogue:ISP
1bitA01						Unbound		Unbound	Unbound	Unbound
1bzxE01						Bound:LYS_515-ALA_516 (chain I)		Unbound	Unbound	Unbound
1tbsA01						Unbound		Unbound	Unbound	Unbound
2staE01						Bound:ARG_505-ILE_506 (chain I)		Unbound	Unbound	Unbound
2stbE01						Bound:LYS_505-ILE_506 (chain I)		Unbound	Unbound	Unbound
2tbsA01						Unbound		Unbound	Unbound	Unbound
1a0jA01						Unbound		Unbound	Unbound	Unbound
1a0jB01						Unbound		Unbound	Unbound	Unbound
1a0jC01						Unbound		Unbound	Unbound	Unbound
1a0jD01						Unbound		Unbound	Unbound	Unbound
1braA01						Unbound		Unbound	Unbound	Unbound
1brbE01						Bound:LYS_15-ALA_16 (chain I)		Unbound	Unbound	Unbound
1brcE01						Bound:ARG_15-ALA_16 (chain I)		Unbound	Unbound	Unbound
1trmA01						Unbound		Unbound	Unbound	Unbound
1trmB01						Unbound		Unbound	Unbound	Unbound
2trmA01						Unbound		Unbound	Unbound	Unbound
1amhA01						Unbound		Unbound	Unbound	Unbound
1amhB01						Unbound		Unbound	Unbound	Unbound
1anbA01						Unbound		Unbound	Unbound	Unbound
1ancA01						Unbound		Unbound	Unbound	Unbound
1andA01						Unbound		Unbound	Unbound	Unbound
1aneA01						Unbound		Unbound	Unbound	Unbound
1dpoA01						Unbound		Unbound	Unbound	Unbound
1ezsC01						Bound:ARG_284-MET_285 (chain B)		Unbound	Unbound	Unbound
1ezsD01						Bound:ARG_84-MET_85 (chain A)		Unbound	Unbound	Unbound
1ezuC01						Analogue:MET_284-MET_285 (chain B)		Unbound	Unbound	Unbound
1ezuD01						Analogue:MET_84-MET_85 (chain A)		Unbound	Unbound	Unbound
1fy8E01						Bound:LYS_15-ALA_16 (chain I)		Unbound	Unbound	Unbound
1i99E01						Bound:LYS_353-SER_354 (chain I)		Unbound	Unbound	Unbound
1ql9A01						Unbound		Unbound	Unbound	Unbound
1sluB01						Analogue:MET_84-MET_85 (chain A)		Unbound	Unbound	Unbound
1slvB01						Analogue:MET_84-MET_85 (chain A)		Unbound	Unbound	Unbound
1slwB01						Analogue:MET_84-MET_85 (chain A)		Unbound	Unbound	Unbound
1slxB01						Analogue:MET_84-MET_85 (chain A)		Unbound	Unbound	Unbound
3tgiE01						Bound:LYS_15-ALA_16 (chain I)		Unbound	Unbound	Unbound
3tgjE01						Bound:LYS_15-ALA_16 (chain I)		Unbound	Unbound	Unbound
1aksB						Unbound		Unbound	Unbound	Unbound
1an1E01						Bound:LYS_8-ILE_9 (chain I)		Unbound	Unbound	Unbound
1avwA01						Bound:ARG_563-ILE_564 (chain B)		Unbound	Unbound	Unbound
1avxA01						Bound:ARG_563-ILE_564 (chain B)		Unbound	Unbound	Unbound
1ejaA01						Bound:LYS_34-VAL_35 (chain B)		Unbound	Unbound	Unbound
1eptC						Unbound		Unbound	Unbound	Unbound
1fmgA01						Unbound		Unbound	Unbound	Unbound
1fn6A01						Unbound		Unbound	Unbound	Unbound
1fniA01						Unbound		Unbound	Unbound	Unbound
1ldtT01						Bound:LYS_8-ILE_9 (chain L)		Unbound	Unbound	Unbound
1mctA01						Bound:ARG_5-ILE_6 (chain I)		Unbound	Unbound	Unbound
1qquA01						Unbound		Unbound	Unbound	Unbound
1tfxA01						Bound:ARG_15-GLY_16 (chain C)		Unbound	Unbound	Unbound
1tfxB01						Bound:ARG_15-GLY_16 (chain D)		Unbound	Unbound	Unbound
1aq7A01						Unbound		Analogue:AEB	Unbound	Unbound
1aujA01						Unbound		Unbound	Unbound	Intermediate-analogue:PPB
1az8A01						Unbound		Unbound	Unbound	Unbound
1bjuA01						Unbound		Unbound	Unbound	Unbound
1bjvA01						Unbound		Unbound	Unbound	Unbound
1btpA01						Unbound		Unbound	Unbound	Unbound
1btwA01						Unbound		Unbound	Unbound	Intermediate-analogue:BOC-ALA-VAL-BLY (chain H)
1btxA01						Unbound		Unbound	Unbound	Intermediate-analogue:BOC-ALA-VAL-BLY-ETH (chain H)
1btyA01						Unbound		Unbound	Unbound	Unbound
1btzA01						Unbound		Unbound	Unbound	Intermediate-analogue:BOC-ALA-VAL-BLY-CH3 (chain H)
1c1nA01						Unbound		Unbound	Unbound	Unbound
1c1oA01						Unbound		Unbound	Unbound	Unbound
1c1pA01						Unbound		Unbound	Unbound	Unbound
1c1qA01						Unbound		Unbound	Unbound	Unbound
1c1rA01						Unbound		Unbound	Unbound	Unbound
1c1sA01						Unbound		Unbound	Unbound	Unbound
1c1tA01						Unbound		Unbound	Unbound	Unbound
1c2dA01						Unbound		Unbound	Unbound	Unbound
1c2eA01						Unbound		Unbound	Unbound	Unbound
1c2fA01						Unbound		Unbound	Unbound	Unbound
1c2gA01						Unbound		Unbound	Unbound	Unbound
1c2hA01						Unbound		Unbound	Unbound	Unbound
1c2iA01						Unbound		Unbound	Unbound	Unbound
1c2jA01						Unbound		Unbound	Unbound	Unbound
1c2kA01						Unbound		Unbound	Unbound	Unbound
1c2lA01						Unbound		Unbound	Unbound	Unbound
1c2mA01						Unbound		Unbound	Unbound	Unbound
1c5pA01						Unbound		Unbound	Unbound	Unbound
1c5qA01						Unbound		Unbound	Unbound	Unbound
1c5rA01						Unbound		Unbound	Unbound	Unbound
1c5sA01						Unbound		Unbound	Unbound	Unbound
1c5tA01						Unbound		Unbound	Unbound	Unbound
1c5uA01						Unbound		Unbound	Unbound	Unbound
1c5vA01						Unbound		Unbound	Unbound	Unbound
1c9pA01						Bound:LYS_34-VAL_35 (chain B)		Unbound	Unbound	Unbound
1ce5A01						Unbound		Unbound	Unbound	Unbound
1d6rA01						Bound:LYS_16-SER_17 (chain I)		Unbound	Unbound	Unbound
1ejmA01						Bound:ARG_515-LEU_516 (chain B)		Unbound	Unbound	Unbound
1ejmC01						Bound:ARG_515-LEU_516 (chain D)		Unbound	Unbound	Unbound
1ejmE01						Bound:ARG_515-LEU_516 (chain F)		Unbound	Unbound	Unbound
1f0tA01						Unbound		Unbound	Unbound	Unbound
1f0uA01						Unbound		Unbound	Unbound	Unbound
1f2sE01						Bound:ARG_305-ILE_306 (chain I)		Unbound	Unbound	Unbound
1g3bA01						Unbound		Unbound	Unbound	Unbound
1g3cA01						Unbound		Unbound	Unbound	Unbound
1g3dA01						Unbound		Unbound	Unbound	Unbound
1g3eA01						Unbound		Unbound	Unbound	Unbound
1g9iE01						Bound:LYS_311-SER_312 (chain I)		Unbound	Unbound	Unbound
1gbtA01						Unbound		Unbound	Unbound	Intermediate-analogue:GBS
1jrsA01						Unbound		Unbound	Unbound	Intermediate-bound:ACE-LEU-LEU-ARG (chain B)
1jrtA01						Unbound		Unbound	Unbound	Intermediate-bound:ACE-LEU-LEU-ARG (chain B)
1maxA01						Unbound		Unbound	Unbound	Intermediate-analogue:ZAP
1mayA01						Unbound		Unbound	Unbound	Intermediate-analogue:ZAP
1mcuE01						Bound:ARG_305-ILE_306 (chain I)		Unbound	Unbound	Unbound
1mtsA01						Unbound		Unbound	Unbound	Unbound
1mtuA01						Unbound		Unbound	Unbound	Unbound
1mtvA01						Unbound		Unbound	Unbound	Unbound
1mtwA01						Unbound		Unbound	Unbound	Unbound
1ntpA01						Unbound		Unbound	Unbound	Intermediate-analogue:MIP
1ppcE01						Unbound		Analogue:NAS-GLY-APH-PIP (chain I)	Unbound	Unbound
1ppeE01						Bound:ARG_5-ILE_6 (chain I)		Unbound	Unbound	Unbound
1pphE01						Unbound		Analogue:TOS-APM-PIP (chain I)	Unbound	Unbound
1qa0A01						Unbound		Unbound	Unbound	Unbound
1qb1A01						Unbound		Unbound	Unbound	Unbound
1qb6A01						Unbound		Unbound	Unbound	Unbound
1qb9A01						Unbound		Unbound	Unbound	Unbound
1qbnA01						Unbound		Unbound	Unbound	Unbound
1qboA01						Unbound		Unbound	Unbound	Unbound
1ql7A01						Unbound		Unbound	Unbound	Unbound
1ql8A01						Unbound		Unbound	Unbound	Unbound
1sbwA01						Bound:LYS_20-SER_21 (chain I)		Unbound	Unbound	Unbound
1sfiA01						Bound:LYS_5-SER_6 (chain I)		Unbound	Unbound	Unbound
1smfE01						Bound:LYS_11-SER_12 (chain I)		Unbound	Unbound	Unbound
1tabE01						Bound:LYS_26-SER_27 (chain I)		Unbound	Unbound	Unbound
1tawA01						Bound:ARG_15-ALA_16 (chain B)		Unbound	Unbound	Unbound
1tgbA01						Unbound		Unbound	Unbound	Unbound
1tgcA01						Unbound		Unbound	Unbound	Unbound
1tgnA01						Unbound		Unbound	Unbound	Unbound
1tgsZ01						Bound:LYS_18-ILE_19 (chain I)		Unbound	Unbound	Unbound
1tgtA01						Unbound		Unbound	Unbound	Unbound
1tioA01						Unbound		Unbound	Unbound	Unbound
1tldA01						Unbound		Unbound	Unbound	Unbound
1tngA01						Unbound		Unbound	Unbound	Unbound
1tnhA01						Unbound		Unbound	Unbound	Unbound
1tniA01						Unbound		Unbound	Unbound	Unbound
1tnjA01						Unbound		Unbound	Unbound	Unbound
1tnkA01						Unbound		Unbound	Unbound	Unbound
1tnlA01						Unbound		Unbound	Unbound	Unbound
1tpaE01						Bound:LYS_15-ALA_16 (chain I)		Unbound	Unbound	Unbound
1tpoA01						Unbound		Unbound	Unbound	Unbound
1tppA01						Unbound		Unbound	Unbound	Intermediate-analogue:APA
1tpsA01						Analogue:A9A		Unbound	Unbound	Unbound
1tynA01						Unbound		Unbound	Unbound	Intermediate-analogue:CTA
1xufA01						Unbound		Unbound	Unbound	Unbound
1xugA01						Unbound		Unbound	Unbound	Unbound
1xuhA01						Unbound		Unbound	Unbound	Unbound
1xuiA01						Unbound		Unbound	Unbound	Unbound
1xujA01						Unbound		Unbound	Unbound	Unbound
1xukA01						Unbound		Unbound	Unbound	Unbound
1yyy101						Unbound		Unbound	Unbound	Intermediate-analogue:BNS-NVA-GLY-3GA
2btcE01						Bound:LYS_505-ILE_506 (chain I)		Unbound	Unbound	Unbound
2bzaA01						Unbound		Unbound	Unbound	Unbound
2ptcE01						Bound:LYS_15-ALA_16 (chain I)		Unbound	Unbound	Unbound
2ptnA01						Unbound		Unbound	Unbound	Unbound
2tgaA01						Unbound		Unbound	Unbound	Unbound
2tgdA01						Unbound		Unbound	Unbound	Intermediate-analogue:DFP
2tgpZ01						Bound:LYS_15-ALA_16 (chain I)		Unbound	Unbound	Unbound
2tgtA01						Unbound		Unbound	Unbound	Unbound
2tioA01						Unbound		Unbound	Unbound	Unbound
2tpiZ01						Bound:LYS_15-ALA_16 (chain I)		Unbound	Unbound	Unbound
3btdE01						Analogue:ASP_515-ALA_516 (chain I)		Unbound	Unbound	Unbound
3bteE01						Analogue:GLU_515-ALA_516 (chain I)		Unbound	Unbound	Unbound
3btfE01						Analogue:PHE_515-ALA_516 (chain I)		Unbound	Unbound	Unbound
3btgE01						Analogue:GLY_515-ALA_516 (chain I)		Unbound	Unbound	Unbound
3bthE01						Analogue:HIS_515-ALA_516 (chain I)		Unbound	Unbound	Unbound
3btkE01						Bound:LYS_515-ALA_516 (chain I)		Unbound	Unbound	Unbound
3btmE01						Analogue:MET_515-ALA_516 (chain I)		Unbound	Unbound	Unbound
3btqE01						Analogue:GLN_515-ALA_516 (chain I)		Unbound	Unbound	Unbound
3bttE01						Analogue:THR_515-ALA_516 (chain I)		Unbound	Unbound	Unbound
3btwE01						Analogue:TRP_515-ALA_516 (chain I)		Unbound	Unbound	Unbound
3ptbA01						Unbound		Unbound	Unbound	Unbound
3ptnA01						Unbound		Unbound	Unbound	Unbound
3tpiZ01						Bound:LYS_15-ALA_16 (chain I)		Unbound	Unbound	Unbound
4ptpA01						Unbound		Unbound	Unbound	Intermediate-analogue:DIP
4tpiZ01						Bound:ARG_15-ALA_16 (chain I)		Unbound	Unbound	Unbound
5ptpA01						Unbound		Unbound	Unbound	Intermediate-analogue:MIS
1ezxC01						Unbound		Bound:SER_359 (chain B)	Unbound	Intermediate-bound:MET_358 (chain A)
1trnA01						Unbound		Unbound	Unbound	Intermediate-analogue:ISP
1trnB01						Unbound		Unbound	Unbound	Intermediate-analogue:ISP
1sgtA02						Unbound		Unbound	Unbound	Unbound
1fn8A02						Unbound		Unbound	Unbound	Unbound
1fy4A02						Unbound		Unbound	Unbound	Unbound
1fy5A02						Unbound		Unbound	Unbound	Unbound
1gdnA02						Unbound		Unbound	Unbound	Unbound
1gdqA02						Unbound		Unbound	Unbound	Unbound
1gduA02						Unbound		Unbound	Unbound	Unbound
1tryA02						Unbound		Unbound	Unbound	Unbound
1bitA02						Unbound		Unbound	Unbound	Unbound
1bzxE02						Unbound		Unbound	Unbound	Unbound
1tbsA02						Unbound		Unbound	Unbound	Unbound
2staE02						Unbound		Unbound	Unbound	Unbound
2stbE02						Unbound		Unbound	Unbound	Unbound
2tbsA02						Unbound		Unbound	Unbound	Unbound
1a0jA02						Unbound		Unbound	Unbound	Unbound
1a0jB02						Unbound		Unbound	Unbound	Unbound
1a0jC02						Unbound		Unbound	Unbound	Unbound
1a0jD02						Unbound		Unbound	Unbound	Unbound
1braA02						Unbound		Unbound	Unbound	Unbound
1brbE02						Unbound		Unbound	Unbound	Unbound
1brcE02						Unbound		Unbound	Unbound	Unbound
1trmA02						Unbound		Unbound	Unbound	Unbound
1trmB02						Unbound		Unbound	Unbound	Unbound
2trmA02						Unbound		Unbound	Unbound	Unbound
1amhA02						Unbound		Unbound	Unbound	Unbound
1amhB02						Unbound		Unbound	Unbound	Unbound
1anbA02						Unbound		Unbound	Unbound	Unbound
1ancA02						Unbound		Unbound	Unbound	Unbound
1andA02						Unbound		Unbound	Unbound	Unbound
1aneA02						Unbound		Unbound	Unbound	Unbound
1dpoA02						Unbound		Unbound	Unbound	Unbound
1ezsC02						Unbound		Unbound	Unbound	Unbound
1ezsD02						Unbound		Unbound	Unbound	Unbound
1ezuC02						Unbound		Unbound	Unbound	Unbound
1ezuD02						Unbound		Unbound	Unbound	Unbound
1fy8E02						Unbound		Unbound	Unbound	Unbound
1i99E02						Unbound		Unbound	Unbound	Unbound
1ql9A02						Unbound		Unbound	Unbound	Unbound
1sluB02						Unbound		Unbound	Unbound	Unbound
1slvB02						Unbound		Unbound	Unbound	Unbound
1slwB02						Unbound		Unbound	Unbound	Unbound
1slxB02						Unbound		Unbound	Unbound	Unbound
3tgiE02						Unbound		Unbound	Unbound	Unbound
3tgjE02						Unbound		Unbound	Unbound	Unbound
1aksA						Unbound		Unbound	Unbound	Unbound
1an1E02						Unbound		Unbound	Unbound	Unbound
1avwA02						Unbound		Unbound	Unbound	Unbound
1avxA02						Unbound		Unbound	Unbound	Unbound
1ejaA02						Unbound		Unbound	Unbound	Unbound
1eptA						Unbound		Unbound	Unbound	Unbound
1eptB						Unbound		Unbound	Unbound	Unbound
1fmgA02						Unbound		Unbound	Unbound	Unbound
1fn6A02						Unbound		Unbound	Unbound	Unbound
1fniA02						Unbound		Unbound	Unbound	Unbound
1ldtT02						Unbound		Unbound	Unbound	Unbound
1mctA02						Unbound		Unbound	Unbound	Unbound
1qquA02						Unbound		Unbound	Unbound	Unbound
1tfxA02						Unbound		Unbound	Unbound	Unbound
1tfxB02						Unbound		Unbound	Unbound	Unbound
1aq7A02						Unbound		Unbound	Unbound	Unbound
1aujA02						Unbound		Unbound	Unbound	Unbound
1az8A02						Unbound		Unbound	Unbound	Unbound
1bjuA02						Unbound		Unbound	Unbound	Unbound
1bjvA02						Unbound		Unbound	Unbound	Unbound
1btpA02						Unbound		Unbound	Unbound	Unbound
1btwA02						Unbound		Unbound	Unbound	Unbound
1btxA02						Unbound		Unbound	Unbound	Unbound
1btyA02						Unbound		Unbound	Unbound	Unbound
1btzA02						Unbound		Unbound	Unbound	Unbound
1c1nA02						Unbound		Unbound	Unbound	Unbound
1c1oA02						Unbound		Unbound	Unbound	Unbound
1c1pA02						Unbound		Unbound	Unbound	Unbound
1c1qA02						Unbound		Unbound	Unbound	Unbound
1c1rA02						Unbound		Unbound	Unbound	Unbound
1c1sA02						Unbound		Unbound	Unbound	Unbound
1c1tA02						Unbound		Unbound	Unbound	Unbound
1c2dA02						Unbound		Unbound	Unbound	Unbound
1c2eA02						Unbound		Unbound	Unbound	Unbound
1c2fA02						Unbound		Unbound	Unbound	Unbound
1c2gA02						Unbound		Unbound	Unbound	Unbound
1c2hA02						Unbound		Unbound	Unbound	Unbound
1c2iA02						Unbound		Unbound	Unbound	Unbound
1c2jA02						Unbound		Unbound	Unbound	Unbound
1c2kA02						Unbound		Unbound	Unbound	Unbound
1c2lA02						Unbound		Unbound	Unbound	Unbound
1c2mA02						Unbound		Unbound	Unbound	Unbound
1c5pA02						Unbound		Unbound	Unbound	Unbound
1c5qA02						Unbound		Unbound	Unbound	Unbound
1c5rA02						Unbound		Unbound	Unbound	Unbound
1c5sA02						Unbound		Unbound	Unbound	Unbound
1c5tA02						Unbound		Unbound	Unbound	Unbound
1c5uA02						Unbound		Unbound	Unbound	Unbound
1c5vA02						Unbound		Unbound	Unbound	Unbound
1c9pA02						Unbound		Unbound	Unbound	Unbound
1ce5A02						Unbound		Unbound	Unbound	Unbound
1d6rA02						Unbound		Unbound	Unbound	Unbound
1ejmA02						Unbound		Unbound	Unbound	Unbound
1ejmC02						Unbound		Unbound	Unbound	Unbound
1ejmE02						Unbound		Unbound	Unbound	Unbound
1f0tA02						Unbound		Unbound	Unbound	Unbound
1f0uA02						Unbound		Unbound	Unbound	Unbound
1f2sE02						Unbound		Unbound	Unbound	Unbound
1g3bA02						Unbound		Unbound	Unbound	Unbound
1g3cA02						Unbound		Unbound	Unbound	Unbound
1g3dA02						Unbound		Unbound	Unbound	Unbound
1g3eA02						Unbound		Unbound	Unbound	Unbound
1g9iE02						Unbound		Unbound	Unbound	Unbound
1gbtA02						Unbound		Unbound	Unbound	Unbound
1jrsA02						Unbound		Unbound	Unbound	Unbound
1jrtA02						Unbound		Unbound	Unbound	Unbound
1maxA02						Unbound		Unbound	Unbound	Unbound
1mayA02						Unbound		Unbound	Unbound	Unbound
1mcuE02						Unbound		Unbound	Unbound	Unbound
1mtsA02						Unbound		Unbound	Unbound	Unbound
1mtuA02						Unbound		Unbound	Unbound	Unbound
1mtvA02						Unbound		Unbound	Unbound	Unbound
1mtwA02						Unbound		Unbound	Unbound	Unbound
1ntpA02						Unbound		Unbound	Unbound	Unbound
1ppcE02						Unbound		Unbound	Unbound	Unbound
1ppeE02						Unbound		Unbound	Unbound	Unbound
1pphE02						Unbound		Unbound	Unbound	Unbound
1qa0A02						Unbound		Unbound	Unbound	Unbound
1qb1A02						Unbound		Unbound	Unbound	Unbound
1qb6A02						Unbound		Unbound	Unbound	Unbound
1qb9A02						Unbound		Unbound	Unbound	Unbound
1qbnA02						Unbound		Unbound	Unbound	Unbound
1qboA02						Unbound		Unbound	Unbound	Unbound
1ql7A02						Unbound		Unbound	Unbound	Unbound
1ql8A02						Unbound		Unbound	Unbound	Unbound
1sbwA02						Unbound		Unbound	Unbound	Unbound
1sfiA02						Unbound		Unbound	Unbound	Unbound
1smfE02						Unbound		Unbound	Unbound	Unbound
1tabE02						Unbound		Unbound	Unbound	Unbound
1tawA02						Unbound		Unbound	Unbound	Unbound
1tgbA02						Unbound		Unbound	Unbound	Unbound
1tgcA02						Unbound		Unbound	Unbound	Unbound
1tgnA02						Unbound		Unbound	Unbound	Unbound
1tgsZ02						Unbound		Unbound	Unbound	Unbound
1tgtA02						Unbound		Unbound	Unbound	Unbound
1tioA02						Unbound		Unbound	Unbound	Unbound
1tldA02						Unbound		Unbound	Unbound	Unbound
1tngA02						Unbound		Unbound	Unbound	Unbound
1tnhA02						Unbound		Unbound	Unbound	Unbound
1tniA02						Unbound		Unbound	Unbound	Unbound
1tnjA02						Unbound		Unbound	Unbound	Unbound
1tnkA02						Unbound		Unbound	Unbound	Unbound
1tnlA02						Unbound		Unbound	Unbound	Unbound
1tpaE02						Unbound		Unbound	Unbound	Unbound
1tpoA02						Unbound		Unbound	Unbound	Unbound
1tppA02						Unbound		Unbound	Unbound	Unbound
1tpsA02						Unbound		Unbound	Unbound	Unbound
1tynA02						Unbound		Unbound	Unbound	Unbound
1xufA02						Unbound		Unbound	Unbound	Unbound
1xugA02						Unbound		Unbound	Unbound	Unbound
1xuhA02						Unbound		Unbound	Unbound	Unbound
1xuiA02						Unbound		Unbound	Unbound	Unbound
1xujA02						Unbound		Unbound	Unbound	Unbound
1xukA02						Unbound		Unbound	Unbound	Unbound
1yyy102						Unbound		Unbound	Unbound	Unbound
2btcE02						Unbound		Unbound	Unbound	Unbound
2bzaA02						Unbound		Unbound	Unbound	Unbound
2ptcE02						Unbound		Unbound	Unbound	Unbound
2ptnA02						Unbound		Unbound	Unbound	Unbound
2tgaA02						Unbound		Unbound	Unbound	Unbound
2tgdA02						Unbound		Unbound	Unbound	Unbound
2tgpZ02						Unbound		Unbound	Unbound	Unbound
2tgtA02						Unbound		Unbound	Unbound	Unbound
2tioA02						Unbound		Unbound	Unbound	Unbound
2tpiZ02						Unbound		Unbound	Unbound	Unbound
3btdE02						Unbound		Unbound	Unbound	Unbound
3bteE02						Unbound		Unbound	Unbound	Unbound
3btfE02						Unbound		Unbound	Unbound	Unbound
3btgE02						Unbound		Unbound	Unbound	Unbound
3bthE02						Unbound		Unbound	Unbound	Unbound
3btkE02						Unbound		Unbound	Unbound	Unbound
3btmE02						Unbound		Unbound	Unbound	Unbound
3btqE02						Unbound		Unbound	Unbound	Unbound
3bttE02						Unbound		Unbound	Unbound	Unbound
3btwE02						Unbound		Unbound	Unbound	Unbound
3ptbA02						Unbound		Unbound	Unbound	Unbound
3ptnA02						Unbound		Unbound	Unbound	Unbound
3tpiZ02						Unbound		Unbound	Unbound	Unbound
4ptpA02						Unbound		Unbound	Unbound	Unbound
4tpiZ02						Unbound		Unbound	Unbound	Unbound
5ptpA02						Unbound		Unbound	Unbound	Unbound
1ezxC02						Unbound		Unbound	Unbound	Unbound
1trnA02						Unbound		Unbound	Unbound	Unbound
1trnB02						Unbound		Unbound	Unbound	Unbound

Reference for Active-site residues
resource	references	E.C.

Active-site residues
PDB						Catalytic residues	Cofactor-binding residues	Modified residues	Main-chain involved in catalysis	Comment
1sgtA01						SER 195			GLY 193;SER 195
1fn8A01						SER 195			GLY 193;SER 195
1fy4A01						SER 195			GLY 193;SER 195
1fy5A01						SER 195			GLY 193;SER 195
1gdnA01						SER 195			GLY 193;SER 195
1gdqA01						SER 195			GLY 193;SER 195
1gduA01						SER 195			GLY 193;SER 195
1tryA01						SER 195			GLY 193;SER 195
1bitA01						SER 195			GLY 193;SER 195
1bzxE01						SER 195			GLY 193;SER 195
1tbsA01						SER 195			GLY 193;SER 195
2staE01						SER 195			GLY 193;SER 195
2stbE01						SER 195			GLY 193;SER 195
2tbsA01						SER 195			GLY 193;SER 195
1a0jA01						SER 195			GLY 193;SER 195
1a0jB01						SER 195			GLY 193;SER 195
1a0jC01						SER 195			GLY 193;SER 195
1a0jD01						SER 195			GLY 193;SER 195
1braA01						SER 195			GLY 193;SER 195	mutant D189G, G226D
1brbE01						SER 195			GLY 193;SER 195	mutant D189G, G226D
1brcE01						SER 195			GLY 193;SER 195	mutant D189G, G226D
1trmA01						SER 195			GLY 193;SER 195
1trmB01						SER 195			GLY 193;SER 195
2trmA01						SER 195			GLY 193;SER 195
1amhA01						SER 195			GLY 193;SER 195	mutant D189S
1amhB01						SER 195			GLY 193;SER 195	mutant D189S
1anbA01						SER 195			GLY 193;SER 195	mutant S214E
1ancA01						SER 195			GLY 193;SER 195	mutant S214K
1andA01						SER 195			GLY 193;SER 195
1aneA01						SER 195			GLY 193;SER 195
1dpoA01									GLY 193;	mutant S195C
1ezsC01						SER 595			GLY 593;SER 595
1ezsD01						SER 895			GLY 893;SER 895
1ezuC01						SER 595			GLY 593;SER 595
1ezuD01						SER 895			GLY 893;SER 895
1fy8E01						SER 195			GLY 193;SER 195
1i99E01									GLY 193;	mutant S195A
1ql9A01						SER 195			GLY 193;SER 195
1sluB01						SER 195			GLY 193;SER 195	mutant N143H, E151H
1slvB01						SER 195			GLY 193;SER 195	mutant N143H, E151H
1slwB01						SER 195			GLY 193;SER 195	mutant V121I, N143H, E151H
1slxB01						SER 195			GLY 193;SER 195	mutant N143H, E151H
3tgiE01						SER 195			GLY 193;SER 195
3tgjE01									GLY 193;	mutant S195A
1aksB						SER 195			GLY 193;SER 195
1an1E01						SER 195			GLY 193;SER 195
1avwA01						SER 195			GLY 193;SER 195
1avxA01						SER 195			GLY 193;SER 195
1ejaA01						SER 195			GLY 193;SER 195
1eptC						SER 195			GLY 193;SER 195
1fmgA01						SER 195			GLY 193;SER 195
1fn6A01						SER 195			GLY 193;SER 195
1fniA01						SER 195			GLY 193;SER 195
1ldtT01						SER 195			GLY 193;SER 195
1mctA01						SER 195			GLY 193;SER 195
1qquA01						SER 195			GLY 193;SER 195
1tfxA01						SER 195			GLY 193;SER 195
1tfxB01						SER 195			GLY 193;SER 195
1aq7A01						SER 195			GLY 193;SER 195
1aujA01						SER 195			GLY 193;SER 195
1az8A01						SER 195			GLY 193;SER 195
1bjuA01						SER 195			GLY 193;SER 195
1bjvA01						SER 195			GLY 193;SER 195
1btpA01						SER 195			GLY 193;SER 195
1btwA01						SER 195			GLY 193;SER 195
1btxA01						SER 195			GLY 193;SER 195
1btyA01						SER 195			GLY 193;SER 195
1btzA01						SER 195			GLY 193;SER 195
1c1nA01						SER 195			GLY 193;SER 195
1c1oA01						SER 195			GLY 193;SER 195
1c1pA01						SER 195			GLY 193;SER 195
1c1qA01						SER 195			GLY 193;SER 195
1c1rA01						SER 195			GLY 193;SER 195
1c1sA01						SER 195			GLY 193;SER 195
1c1tA01						SER 195			GLY 193;SER 195
1c2dA01						SER 195			GLY 193;SER 195
1c2eA01						SER 195			GLY 193;SER 195
1c2fA01						SER 195			GLY 193;SER 195
1c2gA01						SER 195			GLY 193;SER 195
1c2hA01						SER 195			GLY 193;SER 195
1c2iA01						SER 195			GLY 193;SER 195
1c2jA01						SER 195			GLY 193;SER 195
1c2kA01						SER 195			GLY 193;SER 195
1c2lA01						SER 195			GLY 193;SER 195
1c2mA01						SER 195			GLY 193;SER 195
1c5pA01						SER 195			GLY 193;SER 195
1c5qA01						SER 195			GLY 193;SER 195
1c5rA01						SER 195			GLY 193;SER 195
1c5sA01						SER 195			GLY 193;SER 195
1c5tA01						SER 195			GLY 193;SER 195
1c5uA01						SER 195			GLY 193;SER 195
1c5vA01						SER 195			GLY 193;SER 195
1c9pA01						SER 195			GLY 193;SER 195
1ce5A01						SER 195			GLY 193;SER 195
1d6rA01						SER 195			GLY 193;SER 195
1ejmA01						SER 195			GLY 193;SER 195	mutant A16L
1ejmC01						SER 195			GLY 193;SER 195	mutant A16L
1ejmE01						SER 195			GLY 193;SER 195	mutant A16L
1f0tA01						SER 195			GLY 193;SER 195
1f0uA01						SER 195			GLY 193;SER 195
1f2sE01						SER 195			GLY 193;SER 195
1g3bA01						SER 195			GLY 193;SER 195
1g3cA01						SER 195			GLY 193;SER 195
1g3dA01						SER 195			GLY 193;SER 195
1g3eA01						SER 195			GLY 193;SER 195
1g9iE01						SER 195			GLY 193;SER 195
1gbtA01						SER 195			GLY 193;SER 195
1jrsA01						SER 195			GLY 193;SER 195
1jrtA01						SER 195			GLY 193;SER 195
1maxA01						SER 195			GLY 193;SER 195
1mayA01						SER 195			GLY 193;SER 195
1mcuE01						SER 195			GLY 193;SER 195
1mtsA01						SER 195			GLY 193;SER 195
1mtuA01						SER 195			GLY 193;SER 195
1mtvA01						SER 195			GLY 193;SER 195
1mtwA01						SER 195			GLY 193;SER 195
1ntpA01						SER 195			GLY 193;SER 195
1ppcE01						SER 195			GLY 193;SER 195
1ppeE01						SER 195			GLY 193;SER 195
1pphE01						SER 195			GLY 193;SER 195
1qa0A01						SER 183			GLY 181;SER 183
1qb1A01						SER 183			GLY 181;SER 183
1qb6A01						SER 183			GLY 181;SER 183
1qb9A01						SER 183			GLY 181;SER 183
1qbnA01						SER 183			GLY 181;SER 183
1qboA01						SER 183			GLY 181;SER 183
1ql7A01						SER 195			GLY 193;SER 195
1ql8A01						SER 195			GLY 193;SER 195
1sbwA01						SER 195			GLY 193;SER 195
1sfiA01						SER 195			GLY 193;SER 195
1smfE01						SER 195			GLY 193;SER 195
1tabE01						SER 195			GLY 193;SER 195
1tawA01						SER 195			GLY 193;SER 195
1tgbA01						SER 195			GLY 193;SER 195
1tgcA01						SER 195			GLY 193;SER 195
1tgnA01						SER 195			GLY 193;SER 195
1tgsZ01						SER 195			GLY 193;SER 195
1tgtA01						SER 195			GLY 193;SER 195
1tioA01						SER 195			GLY 193;SER 195
1tldA01						SER 195			GLY 193;SER 195
1tngA01						SER 195			GLY 193;SER 195
1tnhA01						SER 195			GLY 193;SER 195
1tniA01						SER 195			GLY 193;SER 195
1tnjA01						SER 195			GLY 193;SER 195
1tnkA01						SER 195			GLY 193;SER 195
1tnlA01						SER 195			GLY 193;SER 195
1tpaE01						SER 195			GLY 193;SER 195
1tpoA01						SER 195			GLY 193;SER 195
1tppA01						SER 195			GLY 193;SER 195
1tpsA01						SER 195			GLY 193;SER 195
1tynA01						SER 195			GLY 193;SER 195
1xufA01						SER 195			GLY 193;SER 195
1xugA01						SER 195			GLY 193;SER 195
1xuhA01						SER 195			GLY 193;SER 195
1xuiA01						SER 195			GLY 193;SER 195
1xujA01						SER 195			GLY 193;SER 195
1xukA01						SER 195			GLY 193;SER 195
1yyy101						SER 195			GLY 193;SER 195
2btcE01						SER 195			GLY 193;SER 195
2bzaA01						SER 195			GLY 193;SER 195
2ptcE01						SER 195			GLY 193;SER 195
2ptnA01						SER 195			GLY 193;SER 195
2tgaA01						SER 195			GLY 193;SER 195
2tgdA01						SER 195			GLY 193;SER 195
2tgpZ01						SER 195			GLY 193;SER 195
2tgtA01						SER 195			GLY 193;SER 195
2tioA01						SER 195			GLY 193;SER 195
2tpiZ01						SER 195			GLY 193;SER 195
3btdE01						SER 195			GLY 193;SER 195
3bteE01						SER 195			GLY 193;SER 195
3btfE01						SER 195			GLY 193;SER 195
3btgE01						SER 195			GLY 193;SER 195
3bthE01						SER 195			GLY 193;SER 195
3btkE01						SER 195			GLY 193;SER 195
3btmE01						SER 195			GLY 193;SER 195
3btqE01						SER 195			GLY 193;SER 195
3bttE01						SER 195			GLY 193;SER 195
3btwE01						SER 195			GLY 193;SER 195
3ptbA01						SER 195			GLY 193;SER 195
3ptnA01						SER 195			GLY 193;SER 195
3tpiZ01						SER 195			GLY 193;SER 195
4ptpA01						SER 195			GLY 193;SER 195
4tpiZ01						SER 195			GLY 193;SER 195
5ptpA01								MIS 195(monoisopropyl-phosphorylated)	GLY 193;MIS 195
1ezxC01						SER 195			GLY 193;SER 195
1trnA01						SER 195			GLY 193;SER 195
1trnB01						SER 195			GLY 193;SER 195
1sgtA02						HIS 57;ASP 102
1fn8A02						HIS 57;ASP 102
1fy4A02						HIS 57;ASP 102
1fy5A02						HIS 57;ASP 102
1gdnA02						HIS 57;ASP 102
1gdqA02						HIS 57;ASP 102
1gduA02						HIS 57;ASP 102
1tryA02						HIS 57;ASP 102
1bitA02						HIS 57;ASP 102
1bzxE02						HIS 57;ASP 102
1tbsA02						HIS 57;ASP 102
2staE02						HIS 57;ASP 102
2stbE02						HIS 57;ASP 102
2tbsA02						HIS 57;ASP 102
1a0jA02						HIS 57;ASP 102
1a0jB02						HIS 57;ASP 102
1a0jC02						HIS 57;ASP 102
1a0jD02						HIS 57;ASP 102
1braA02						HIS 57;ASP 102
1brbE02						HIS 57;ASP 102
1brcE02						HIS 57;ASP 102
1trmA02						HIS 57;				mutant D102N
1trmB02						HIS 57;				mutant D102N
2trmA02						HIS 57;				mutant D102N
1amhA02						HIS 57;ASP 102
1amhB02						HIS 57;ASP 102
1anbA02						HIS 57;ASP 102
1ancA02						HIS 57;ASP 102
1andA02						HIS 57;ASP 102				mutant R96H
1aneA02						HIS 57;ASP 102
1dpoA02						HIS 57;ASP 102
1ezsC02						HIS 457;				mutant D502N
1ezsD02						HIS 757;				mutant D802N
1ezuC02						HIS 457;				mutant D502N
1ezuD02						HIS 757;				mutant D802N
1fy8E02						HIS 57;ASP 102
1i99E02						HIS 57;ASP 102
1ql9A02						HIS 57;ASP 102
1sluB02						HIS 57;ASP 102
1slvB02						HIS 57;ASP 102
1slwB02						HIS 57;ASP 102
1slxB02						HIS 57;ASP 102
3tgiE02						HIS 57;ASP 102
3tgjE02						HIS 57;ASP 102
1aksA						HIS 57;ASP 102
1an1E02						HIS 57;ASP 102
1avwA02						HIS 57;ASP 102
1avxA02						HIS 57;ASP 102
1ejaA02						HIS 57;ASP 102
1eptA						HIS 57;
1eptB						;ASP 102
1fmgA02						HIS 57;ASP 102
1fn6A02						HIS 57;ASP 102
1fniA02						HIS 57;ASP 102
1ldtT02						HIS 57;ASP 102
1mctA02						HIS 57;ASP 102
1qquA02						HIS 57;ASP 102
1tfxA02						HIS 57;ASP 102
1tfxB02						HIS 57;ASP 102
1aq7A02						HIS 57;ASP 102
1aujA02						HIS 57;ASP 102
1az8A02						HIS 57;ASP 102
1bjuA02						HIS 57;ASP 102
1bjvA02						HIS 57;ASP 102
1btpA02						HIS 57;ASP 102
1btwA02						HIS 57;ASP 102
1btxA02						HIS 57;ASP 102
1btyA02						HIS 57;ASP 102
1btzA02						HIS 57;ASP 102
1c1nA02						HIS 57;ASP 102
1c1oA02						HIS 57;ASP 102
1c1pA02						HIS 57;ASP 102
1c1qA02						HIS 57;ASP 102
1c1rA02						HIS 57;ASP 102
1c1sA02						HIS 57;ASP 102
1c1tA02						HIS 57;ASP 102
1c2dA02						HIS 57;ASP 102
1c2eA02						HIS 57;ASP 102
1c2fA02						HIS 57;ASP 102
1c2gA02						HIS 57;ASP 102
1c2hA02						HIS 57;ASP 102
1c2iA02						HIS 57;ASP 102
1c2jA02						HIS 57;ASP 102
1c2kA02						HIS 57;ASP 102
1c2lA02						HIS 57;ASP 102
1c2mA02						HIS 57;ASP 102
1c5pA02						HIS 57;ASP 102
1c5qA02						HIS 57;ASP 102
1c5rA02						HIS 57;ASP 102
1c5sA02						HIS 57;ASP 102
1c5tA02						HIS 57;ASP 102
1c5uA02						HIS 57;ASP 102
1c5vA02						HIS 57;ASP 102
1c9pA02						HIS 57;ASP 102
1ce5A02						HIS 57;ASP 102
1d6rA02						HIS 57;ASP 102
1ejmA02						HIS 57;ASP 102
1ejmC02						HIS 57;ASP 102
1ejmE02						HIS 57;ASP 102
1f0tA02						HIS 57;ASP 102
1f0uA02						HIS 57;ASP 102
1f2sE02						HIS 57;ASP 102
1g3bA02						HIS 57;ASP 102
1g3cA02						HIS 57;ASP 102
1g3dA02						HIS 57;ASP 102
1g3eA02						HIS 57;ASP 102
1g9iE02						HIS 57;ASP 102
1gbtA02						HIS 57;ASP 102
1jrsA02						HIS 57;ASP 102
1jrtA02						HIS 57;ASP 102
1maxA02						HIS 57;ASP 102
1mayA02						HIS 57;ASP 102
1mcuE02						HIS 57;ASP 102
1mtsA02						HIS 57;ASP 102
1mtuA02						HIS 57;ASP 102
1mtvA02						HIS 57;ASP 102
1mtwA02						HIS 57;ASP 102
1ntpA02						HIS 57;ASP 102
1ppcE02						HIS 57;ASP 102
1ppeE02						HIS 57;ASP 102
1pphE02						HIS 57;ASP 102
1qa0A02						HIS 46;ASP 90
1qb1A02						HIS 46;ASP 90
1qb6A02						HIS 46;ASP 90
1qb9A02						HIS 46;ASP 90
1qbnA02						HIS 46;ASP 90
1qboA02						HIS 46;ASP 90
1ql7A02						HIS 57;ASP 102
1ql8A02						HIS 57;ASP 102
1sbwA02						HIS 57;ASP 102
1sfiA02						HIS 57;ASP 102
1smfE02						HIS 57;ASP 102
1tabE02						HIS 57;ASP 102
1tawA02						HIS 57;ASP 102
1tgbA02						HIS 57;ASP 102
1tgcA02						HIS 57;ASP 102
1tgnA02						HIS 57;ASP 102
1tgsZ02						HIS 57;ASP 102
1tgtA02						HIS 57;ASP 102
1tioA02						HIS 57;ASP 102
1tldA02						HIS 57;ASP 102
1tngA02						HIS 57;ASP 102
1tnhA02						HIS 57;ASP 102
1tniA02						HIS 57;ASP 102
1tnjA02						HIS 57;ASP 102
1tnkA02						HIS 57;ASP 102
1tnlA02						HIS 57;ASP 102
1tpaE02						HIS 57;ASP 102
1tpoA02						HIS 57;ASP 102
1tppA02						HIS 57;ASP 102
1tpsA02						HIS 57;ASP 102
1tynA02						HIS 57;ASP 102
1xufA02						HIS 57;ASP 102
1xugA02						HIS 57;ASP 102
1xuhA02						HIS 57;ASP 102
1xuiA02						HIS 57;ASP 102
1xujA02						HIS 57;ASP 102
1xukA02						HIS 57;ASP 102
1yyy102						HIS 57;ASP 102
2btcE02						HIS 57;ASP 102
2bzaA02						HIS 57;ASP 102
2ptcE02						HIS 57;ASP 102
2ptnA02						HIS 57;ASP 102
2tgaA02						HIS 57;ASP 102
2tgdA02						HIS 57;ASP 102
2tgpZ02						HIS 57;ASP 102
2tgtA02						HIS 57;ASP 102
2tioA02						HIS 57;ASP 102
2tpiZ02						HIS 57;ASP 102
3btdE02						HIS 57;ASP 102
3bteE02						HIS 57;ASP 102
3btfE02						HIS 57;ASP 102
3btgE02						HIS 57;ASP 102
3bthE02						HIS 57;ASP 102
3btkE02						HIS 57;ASP 102
3btmE02						HIS 57;ASP 102
3btqE02						HIS 57;ASP 102
3bttE02						HIS 57;ASP 102
3btwE02						HIS 57;ASP 102
3ptbA02						HIS 57;ASP 102
3ptnA02						HIS 57;ASP 102
3tpiZ02						HIS 57;ASP 102
4ptpA02						HIS 57;ASP 102
4tpiZ02						HIS 57;ASP 102
5ptpA02						HIS 57;ASP 102
1ezxC02						HIS 57;ASP 102
1trnA02						HIS 57;ASP 102
1trnB02						HIS 57;ASP 102

References for Catalytic Mechanism
References	Sections	No. of steps in catalysis
[10]	p.905
[47]	Fig.9
[53]	Fig. 2, p.338-340	3
[68]	p.17079
[73]	p.355-356
[78]	p.146
[129]	Fig.2, p.43362	4

References
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Comments	X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF CALCIUM-BINDING SITE.
Medline ID	76072097
PubMed ID	512
Journal	J Mol Biol
Year	1975
Volume	98
Pages	693-717
Authors	Bode W, Schwager P
Title	The refined crystal structure of bovine beta-trypsin at 1.8 A resolution. II. Crystallographic refinement, calcium binding site, benzamidine binding site and active site at pH 7.0.
Related PDB
Related UniProtKB	P00760
[2]
Resource
Comments	X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
Medline ID	77112431
PubMed ID	556951
Journal	Biochemistry
Year	1977
Volume	16
Pages	654-64
Authors	Kossiakoff AA, Chambers JL, Kay LM, Stroud RM
Title	Structure of bovine trypsinogen at 1.9 A resolution.
Related PDB	1tgn
Related UniProtKB	P00760
[3]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	864704
Journal	J Mol Biol
Year	1977
Volume	111
Pages	415-38
Authors	Fehlhammer H, Bode W, Huber R
Title	Crystal structure of bovine trypsinogen at 1-8 A resolution. II. Crystallographic refinement, refined crystal structure and comparison with bovine trypsin.
Related PDB	1tgb
Related UniProtKB
[4]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID
Journal	Acta Crystallogr B
Year	1982
Volume	38
Pages	1462-72
Authors	Walter J, Steigemann W, Singh TP, Bartunik H, Bode W, Huber R
Title	On the disordered activation domain in trypsinogen: chemical labelling and low-temperature crystallography.
Related PDB	1tgc 1tgt 2ptn 2tga 2tgt 2tpi 3ptn
Related UniProtKB
[5]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	7169635
Journal	J Mol Biol
Year	1982
Volume	162
Pages	839-68
Authors	Bolognesi M, Gatti G, Menagatti E, Guarneri M, Marquart M, Papamokos E, Huber R
Title	Three-dimensional structure of the complex between pancreatic secretory trypsin inhibitor (Kazal type) and trypsinogen at 1.8 A resolution. Structure solution, crystallographic refinement and preliminary structural interpretation.
Related PDB	1tgs
Related UniProtKB
[6]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID
Journal	Acta Crystallogr B
Year	1983
Volume	39
Pages	480-90
Authors	Marquart M, Walter J, Deisenhofer J, Bode W, Huber R
Title	The geometry of the reactive site and of the peptide groups in trypsin, trypsinogen and its complexes with inhibitors.
Related PDB	1tpa 1tpo 1tpp 2ptc 2tgp 3ptb 3tpi 1tpo 1tpp 2ptc 2tgp 3ptb 3tpi
Related UniProtKB
[7]
Resource
Comments	Neutron Diffraction
Medline ID
PubMed ID	6712567
Journal	Basic Life Sci
Year	1984
Volume	27
Pages	281-304
Authors	Kossiakoff AA
Title	Use of the neutron diffraction--H/D exchange technique to determine the conformational dynamics of trypsin.
Related PDB	1ntp
Related UniProtKB
[8]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	6207021
Journal	Eur J Biochem
Year	1984
Volume	144
Pages	185-90
Authors	Bode W, Walter J, Huber R, Wenzel HR, Tschesche H
Title	The refined 2.2-A (0.22-nm) X-ray crystal structure of the ternary complex formed by bovine trypsinogen, valine-valine and the Arg15 analogue of bovine pancreatic trypsin inhibitor.
Related PDB	4tpi
Related UniProtKB
[9]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	3032921
Journal	J Biochem (Tokyo)
Year	1986
Volume	100
Pages	1637-46
Authors	Tsunogae Y, Tanaka I, Yamane T, Kikkawa J, Ashida T, Ishikawa C, Watanabe K, Nakamura S, Takahashi K
Title	Structure of the trypsin-binding domain of Bowman-Birk type protease inhibitor and its interaction with trypsin.
Related PDB	1tab
Related UniProtKB
[10]
Resource
Comments	X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
Medline ID	87292123
PubMed ID	3112942
Journal	Science
Year	1987
Volume	237
Pages	905-9
Authors	Sprang S, Standing T, Fletterick RJ, Stroud RM, Finer-Moore J, Xuong NH, Hamlin R, Rutter WJ, Craik CS
Title	The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis.
Related PDB	1trm 2trm
Related UniProtKB	P00762
[11]
Resource
Comments	X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS).
Medline ID	88286735
PubMed ID	3135412
Journal	J Mol Biol
Year	1988
Volume	200
Pages	523-51
Authors	Read RJ, James MN
Title	Refined crystal structure of Streptomyces griseus trypsin at 1.7 A resolution.
Related PDB	1sgt
Related UniProtKB	P00775
[12]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	2914611
Journal	FEBS Lett
Year	1989
Volume	242
Pages	285-92
Authors	Bode W, Greyling HJ, Huber R, Otlewski J, Wilusz T
Title	The refined 2.0 A X-ray crystal structure of the complex formed between bovine beta-trypsin and CMTI-I, a trypsin inhibitor from squash seeds (Cucurbita maxima). Topological similarity of the squash seed inhibitors with the carboxypeptidase A inhibitor from potatoes.
Related PDB	1ppe
Related UniProtKB
[13]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	2614845
Journal	J Mol Biol
Year	1989
Volume	210
Pages	813-28
Authors	Bartunik HD, Summers LJ, Bartsch HH
Title	Crystal structure of bovine beta-trypsin at 1.5 A resolution in a crystal form with low molecular packing density. Active site geometry, ion pairs and solvent structure.
Related PDB	1tld
Related UniProtKB
[14]
Resource
Comments
Medline ID
PubMed ID	2125487
Journal	Biochemistry
Year	1990
Volume	29
Pages	10018-22
Authors	Hynes TR, Randal M, Kennedy LA, Eigenbrot C, Kossiakoff AA
Title	X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid beta-protein precursor.
Related PDB
Related UniProtKB
[15]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	2252895
Journal	Biochemistry
Year	1990
Volume	29
Pages	8351-7
Authors	Mangel WF, Singer PT, Cyr DM, Umland TC, Toledo DL, Stroud RM, Pflugrath JW, Sweet RM
Title	Structure of an acyl-enzyme intermediate during catalysis: (guanidinobenzoyl)trypsin.
Related PDB	1gbt
Related UniProtKB
[16]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	2226434
Journal	Eur J Biochem
Year	1990
Volume	193
Pages	175-82
Authors	Bode W, Turk D, Sturzebecher J
Title	Geometry of binding of the benzamidine- and arginine-based inhibitors N alpha-(2-naphthyl-sulphonyl-glycyl)-DL-p-amidinophenylalanyl-pipe ridine (NAPAP) and (2R,4R)-4-methyl-1-[N alpha-(3-methyl-1,2,3,4-tetrahydro-8- quinolinesulphonyl)-L-arginyl]-2-piperidine carboxylic acid (MQPA) to human alpha-thrombin. X-ray crystallographic determination of the NAPAP-trypsin complex and modeling of NAPAP-thrombin and MQPA-thrombin.
Related PDB	1ppc
Related UniProtKB
[17]
Resource
Comments
Medline ID
PubMed ID	1988014
Journal	Biochemistry
Year	1991
Volume	30
Pages	133-43
Authors	Prestrelski SJ, Byler DM, Liebman MN
Title	Comparison of various molecular forms of bovine trypsin: correlation of infrared spectra with X-ray crystal structures.
Related PDB
Related UniProtKB
[18]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	1879520
Journal	FEBS Lett
Year	1991
Volume	287
Pages	133-8
Authors	Turk D, Sturzebecher J, Bode W
Title	Geometry of binding of the N alpha-tosylated piperidides of m-amidino-, p-amidino- and p-guanidino phenylalanine to thrombin and trypsin. X-ray crystal structures of their trypsin complexes and modeling of their thrombin complexes.
Related PDB	1pph
Related UniProtKB
[19]
Resource
Comments
Medline ID
PubMed ID	1794983
Journal	J Biochem (Tokyo)
Year	1991
Volume	110
Pages	945-50
Authors	Yamane T, Kobuke M, Tsutsui H, Toida T, Suzuki A, Ashida T, Kawata Y, Sakiyama F
Title	Crystal structure of Streptomyces erythraeus trypsin at 2.7 A resolution.
Related PDB
Related UniProtKB
[20]
Resource
Comments
Medline ID
PubMed ID	1714504
Journal	J Mol Biol
Year	1991
Volume	220
Pages	757-70
Authors	Housset D, Kim KS, Fuchs J, Woodward C, Wlodawer A
Title	Crystal structure of a Y35G mutant of bovine pancreatic trypsin inhibitor.
Related PDB
Related UniProtKB
[21]
Resource
Comments
Medline ID
PubMed ID	1904942
Journal	J Mol Biol
Year	1991
Volume	219
Pages	511-23
Authors	Wilke ME, Higaki JN, Craik CS, Fletterick RJ
Title	Crystal structure of rat trypsin-S195C at -150 degrees C. Analysis of low activity of recombinant and semisynthetic thiol proteases.
Related PDB
Related UniProtKB
[22]
Resource
Comments
Medline ID
PubMed ID	2051486
Journal	J Mol Biol
Year	1991
Volume	219
Pages	525-32
Authors	Wilke ME, Higaki JN, Craik CS, Fletterick RJ
Title	Crystallographic analysis of trypsin-G226A. A specificity pocket mutant of rat trypsin with altered binding and catalysis.
Related PDB
Related UniProtKB
[23]
Resource
Comments	X-RAY CRYSTALLOGRAPHY (1.59 ANGSTROMS).
Medline ID	91351998
PubMed ID	1881877
Journal	Proteins
Year	1991
Volume	10
Pages	171-87
Authors	Earnest T, Fauman E, Craik CS, Stroud R
Title	1.59 A structure of trypsin at 120 K: comparison of low temperature and room temperature structures.
Related PDB	1dpo
Related UniProtKB	P00763
[24]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	1554694
Journal	Biochemistry
Year	1992
Volume	31
Pages	3059-64
Authors	McGrath ME, Vasquez JR, Craik CS, Yang AS, Honig B, Fletterick RJ
Title	Perturbing the polar environment of Asp102 in trypsin: consequences of replacing conserved Ser214.
Related PDB	1anb 1anc
Related UniProtKB
[25]
Resource
Comments	X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS).
Medline ID	92201369
PubMed ID	1551419
Journal	FEBS Lett
Year	1992
Volume	297
Pages	143-6
Authors	Huang Q, Liu S, Tang Y, Zeng F, Qian R
Title	Amino acid sequencing of a trypsin inhibitor by refined 1.6 A X-ray crystal structure of its complex with porcine beta-trypsin.
Related PDB
Related UniProtKB	P00761
[26]
Resource
Comments
Medline ID
PubMed ID	1383552
Journal	J Mol Biol
Year	1992
Volume	227
Pages	757-75
Authors	Berndt KD, Guntert P, Orbons LP, Wuthrich K
Title	Determination of a high-quality nuclear magnetic resonance solution structure of the bovine pancreatic trypsin inhibitor and comparison with three crystal structures.
Related PDB
Related UniProtKB
[27]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	1584773
Journal	Proc Natl Acad Sci U S A
Year	1992
Volume	89
Pages	4407-11
Authors	Takeuchi Y, Nonaka T, Nakamura KT, Kojima S, Miura K, Mitsui Y
Title	Crystal structure of an engineered subtilisin inhibitor complexed with bovine trypsin.
Related PDB	2tld
Related UniProtKB
[28]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	1557349
Journal	Proteins
Year	1992
Volume	12
Pages	203-22
Authors	Finer-Moore JS, Kossiakoff AA, Hurley JH, Earnest T, Stroud RM
Title	Solvent structure in crystals of trypsin determined by X-ray and neutron diffraction.
Related PDB	4ptp 5ptp
Related UniProtKB
[29]
Resource
Comments
Medline ID
PubMed ID	1557350
Journal	Proteins
Year	1992
Volume	12
Pages	223-36
Authors	Kossiakoff AA, Sintchak MD, Shpungin J, Presta LG
Title	Analysis of solvent structure in proteins using neutron D2O-H2O solvent maps: pattern of primary and secondary hydration of trypsin.
Related PDB
Related UniProtKB
[30]
Resource
Comments	X-RAY CRYSTALLOGRAPHY (1.82 ANGSTROMS).
Medline ID
PubMed ID	15299521
Journal	Acta Crystallogr D Biol Crystallogr
Year	1993
Volume	49
Pages	318-30
Authors	Smalas AO, Hordvik A
Title	Structure determination and refinement of benzamidine-inhibited trypsin from the North Atlantic salmon (Salmo salar) at 1.82-A resolution.
Related PDB
Related UniProtKB	P35031
[31]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	8448149
Journal	Biochemistry
Year	1993
Volume	32
Pages	1914-9
Authors	McGrath ME, Haymore BL, Summers NL, Craik CS, Fletterick RJ
Title	Structure of an engineered, metal-actuated switch in trypsin.
Related PDB	1and
Related UniProtKB
[32]
Resource
Comments
Medline ID
PubMed ID	8444191
Journal	Eur J Biochem
Year	1993
Volume	212
Pages	549-55
Authors	Lin G, Bode W, Huber R, Chi C, Engh RA
Title	The 0.25-nm X-ray structure of the Bowman-Birk-type inhibitor from mung bean in ternary complex with porcine trypsin.
Related PDB
Related UniProtKB
[33]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID
Journal	J Am Chem Soc
Year	1993
Volume	115
Pages	12619-20
Authors	Lee AY, Hagihara M, Karmacharya R, Albers MW, Schreiber SL, Clardy J
Title	Atomic structure of the trypsin-cyclotheonamide A complex: lessons for the design of serine protease inhibitors.
Related PDB	1tyn
Related UniProtKB
[34]
Resource
Comments	X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS).
Medline ID	93187998
PubMed ID	8445634
Journal	J Mol Biol
Year	1993
Volume	229
Pages	1022-36
Authors	Huang Q, Liu S, Tang Y
Title	Refined 1.6 A resolution crystal structure of the complex formed between porcine beta-trypsin and MCTI-A, a trypsin inhibitor of the squash family. Detailed comparison with bovine beta-trypsin and its complex.
Related PDB	1mct
Related UniProtKB	P00761
[35]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	7683059
Journal	J Mol Biol
Year	1993
Volume	230
Pages	919-33
Authors	Perona JJ, Tsu CA, Craik CS, Fletterick RJ
Title	Crystal structures of rat anionic trypsin complexed with the protein inhibitors APPI and BPTI.
Related PDB	1brb
Related UniProtKB
[36]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	8478942
Journal	J Mol Biol
Year	1993
Volume	230
Pages	934-49
Authors	Perona JJ, Tsu CA, McGrath ME, Craik CS, Fletterick RJ
Title	Relocating a negative charge in the binding pocket of trypsin.
Related PDB	1bra 1brc
Related UniProtKB
[37]
Resource
Comments
Medline ID
PubMed ID	8332590
Journal	Protein Eng
Year	1993
Volume	6
Pages	341-8
Authors	Rypniewski WR, Hastrup S, Betzel C, Dauter M, Dauter Z, Papendorf G, Branner S, Wilson KS
Title	The sequence and X-ray structure of the trypsin from Fusarium oxysporum.
Related PDB
Related UniProtKB
[38]
Resource
Comments	X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS).
Medline ID	95035057
PubMed ID	7947985
Journal	Biochim Biophys Acta
Year	1994
Volume	1209
Pages	77-82
Authors	Huang Q, Wang Z, Li Y, Liu S, Tang Y
Title	Refined 1.8 A resolution crystal structure of the porcine epsilon-trypsin.
Related PDB	1ept
Related UniProtKB	P00761
[39]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	9383379
Journal	Chem Biol
Year	1994
Volume	1
Pages	113-7
Authors	Lee AY, Smitka TA, Bonjouklian R, Clardy J
Title	Atomic structure of the trypsin-A90720A complex: a unified approach to structure and function.
Related PDB	1tps
Related UniProtKB
[40]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	7798176
Journal	J Biochem (Tokyo)
Year	1994
Volume	116
Pages	18-25
Authors	Li Y, Huang Q, Zhang S, Liu S, Chi C, Tang Y
Title	Studies on an artificial trypsin inhibitor peptide derived from the mung bean trypsin inhibitor: chemical synthesis, refolding, and crystallographic analysis of its complex with trypsin.
Related PDB	1g9i 1smf
Related UniProtKB
[41]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	7634078
Journal	Nat Struct Biol
Year	1994
Volume	1
Pages	735-43
Authors	Kurinov IV, Harrison RW
Title	Prediction of new serine proteinase inhibitors.
Related PDB	1tng 1tnh 1tni 1tnj 1tnk 1tnl
Related UniProtKB
[42]
Resource
Comments	X-RAY CRYSTALLOGRAPHY (1.82 ANGSTROMS).
Medline ID	95148588
PubMed ID	7846025
Journal	Proteins
Year	1994
Volume	20
Pages	149-66
Authors	Smalas AO, Heimstad ES, Hordvik A, Willassen NP, Male R
Title	Cold adaption of enzymes: structural comparison between salmon and bovine trypsins.
Related PDB	1tbs 2tbs
Related UniProtKB	P35031
[43]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	15299802
Journal	Acta Crystallogr D Biol Crystallogr
Year	1995
Volume	51
Pages	725-30
Authors	Berglund GI, Smalas AO, Hordvik A, Willassen NP
Title	Structure of anionic salmon trypsin in a second crystal form
Related PDB	1bit
Related UniProtKB
[44]
Resource
Comments	X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS).
Medline ID
PubMed ID	15299338
Journal	Acta Crystallogr D Biol Crystallogr
Year	1995
Volume	51
Pages	73-84
Authors	Rypniewski WR, Dambmann C, von der Osten C, Dauter M, Wilson K.S
Title	Structure of inhibited trypsin from Fusarium oxysporum at 1.55 A.
Related PDB	1try
Related UniProtKB	P35049
[45]
Resource
Comments
Medline ID
PubMed ID	7503719
Journal	Biochem Biophys Res Commun
Year	1995
Volume	217
Pages	437-44
Authors	Ascenzi P, Balliano G, Milla P, Ferraccioli R, Sartori P, Djinovic-Carugo K, Bolognesi M
Title	Inhibition of bovine beta-trypsin by the active site titrant N alpha-(N,N-dimethylcarbamoyl)-alpha-azaornithine p-nitrophenyl ester: a kinetic and X-ray crystallographic study.
Related PDB
Related UniProtKB
[46]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	7599119
Journal	Biochemistry
Year	1995
Volume	34
Pages	8264-80
Authors	Katz BA, Finer-Moore J, Mortezaei R, Rich DH, Stroud RM
Title	Episelection: novel Ki approximately nanomolar inhibitors of serine proteases selected by binding or chemistry on an enzyme surface.
Related PDB	1btw 1btx 1bty 1btz
Related UniProtKB
[47]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	7548040
Journal	Biochemistry
Year	1995
Volume	34
Pages	12849-53
Authors	Odagaki Y, Nakai H, Senokuchi K, Kawamura M, Hamanaka N, Nakamura M, Tomoo K, Ishida T
Title	Unique binding of a novel synthetic inhibitor, N-[3-[4-[4-(amidinophenoxy)carbonyl]phenyl]-2-methyl-2-propenoyl]- N-allylglycine methanesulfonate, to bovine trypsin, revealed by the crystal structure of the complex.
Related PDB	1btp
Related UniProtKB
[48]
Resource
Comments
Medline ID
PubMed ID	7703351
Journal	Biophys Chem
Year	1995
Volume	54
Pages	75-81
Authors	Casale E, Collyer C, Ascenzi P, Balliano G, Milla P, Viola F, Fasano M, Menegatti E, Bolognesi M
Title	Inhibition of bovine beta-trypsin, human alpha-thrombin and porcine pancreatic beta-kallikrein-B by 4',6-diamidino-2-phenylindole, 6-amidinoindole and benzamidine: a comparative thermodynamic and X-ray structural study.
Related PDB
Related UniProtKB
[49]
Resource
Comments
Medline ID
PubMed ID	7821429
Journal	FEBS Lett
Year	1995
Volume	358
Pages	53-6
Authors	Sartori P, Djinovic Carugo K, Ferraccioli R, Balliano G, Milla P, Ascenzi P, Bolognesi M
Title	Active site titration of bovine beta-trypsin by N alpha-(N,N-dimethylcarbamoyl)-alpha-aza-lysine p-nitrophenyl ester: kinetic and crystallographic analysis.
Related PDB
Related UniProtKB
[50]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	7498454
Journal	FEBS Lett
Year	1995
Volume	375
Pages	103-7
Authors	Stubbs MT, Huber R, Bode W
Title	Crystal structures of factor Xa specific inhibitors in complex with trypsin: structural grounds for inhibition of factor Xa and selectivity against thrombin.
Related PDB	1mts 1mtu 1mtv 1mtw
Related UniProtKB
[51]
Resource
Comments
Medline ID
PubMed ID	8749303
Journal	J Biochem (Tokyo)
Year	1995
Volume	118
Pages	882-94
Authors	Yamane T, Iwasaki A, Suzuki A, Ashida T, Kawata Y
Title	Crystal structure of Streptomyces erythraeus trypsin at 1.9 A resolution.
Related PDB
Related UniProtKB
[52]
Resource
Comments
Medline ID
PubMed ID	7616573
Journal	J Mol Biol
Year	1995
Volume	250
Pages	553-70
Authors	McDowell RS, Kossiakoff AA
Title	A comparison of neutron diffraction and molecular dynamics structures: hydroxyl group and water molecule orientations in trypsin.
Related PDB
Related UniProtKB
[53]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	7795518
Journal	Protein Sci
Year	1995
Volume	4
Pages	337-60
Authors	Perona JJ, Craik CS
Title	Structural basis of substrate specificity in the serine proteases.
Related PDB	1amh
Related UniProtKB
[54]
Resource
Comments
Medline ID
PubMed ID	9092457
Journal	Basic Life Sci
Year	1996
Volume	64
Pages	273-87
Authors	McDowell RS, Kossiakoff AA
Title	Hydroxyl and water molecule orientations in trypsin: comparison to molecular dynamic structures.
Related PDB
Related UniProtKB
[55]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	8605148
Journal	Biochemistry
Year	1996
Volume	35
Pages	3147-55
Authors	Bertrand JA, Oleksyszyn J, Kam CM, Boduszek B, Presnell S, Plaskon RR, Suddath FL, Powers JC, Williams LD
Title	Inhibition of trypsin and thrombin by amino(4-amidinophenyl)methanephosphonate diphenyl ester derivatives: X-ray structures and molecular models.
Related PDB	1max 1may
Related UniProtKB
[56]
Resource
Comments	X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
Medline ID	96214506
PubMed ID	8634241
Journal	Biochemistry
Year	1996
Volume	35
Pages	5999-6009
Authors	Brinen LS, Willett WS, Craik CS, Fletterick RJ
Title	X-ray structures of a designed binding site in trypsin show metal-dependent geometry.
Related PDB	1slu 1slv 1slw 1slx
Related UniProtKB	P00763
[57]
Resource
Comments
Medline ID
PubMed ID	8960786
Journal	Clin Chim Acta
Year	1996
Volume	256
Pages	37-51
Authors	Finotti P
Title	Separation by heparin-affinity chromatography of catalytically active and inactive forms of trypsin which retain the (Na-K)ATPase stimulating property.
Related PDB
Related UniProtKB
[58]
Resource
Comments	X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS), AND PHOSPHORYLATION.
Medline ID	96266496
PubMed ID	8683601
Journal	J Mol Biol
Year	1996
Volume	259
Pages	995-1010
Authors	Gaboriaud C, Serre L, Guy-Crotte O, Forest E, Fontecilla-Camps JC
Title	Crystal structure of human trypsin 1: unexpected phosphorylation of Tyr151.
Related PDB	1trn
Related UniProtKB	P07477
[59]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	8845765
Journal	Protein Sci
Year	1996
Volume	5
Pages	752-8
Authors	Kurinov IV, Harrison RW
Title	Two crystal structures of the leupeptin-trypsin complex.
Related PDB	1jrs 1jrt
Related UniProtKB
[60]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	15299934
Journal	Acta Crystallogr D Biol Crystallogr
Year	1997
Volume	53
Pages	311-5
Authors	Johnson A, Krishnaswamy S, Sundaram PV, Pattabhi V
Title	The First Structure at 1.8 A Resolution of an Active Autolysate Form of Porcine [alpha]-Trysoin.
Related PDB	1aks
Related UniProtKB
[61]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	9341205
Journal	Biochemistry
Year	1997
Volume	36
Pages	13180-6
Authors	Lee SL, Alexander RS, Smallwood A, Trievel R, Mersinger L, Weber PC, Kettner C
Title	New inhibitors of thrombin and other trypsin-like proteases: hydrogen bonding of an aromatic cyano group with a backbone amide of the P1 binding site replaces binding of a basic side chain.
Related PDB	1auj
Related UniProtKB
[62]
Resource
Comments	X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF COMPLEX WITH LDTI.
Medline ID	97390427
PubMed ID	9242660
Journal	J Biol Chem
Year	1997
Volume	272
Pages	19931-7
Authors	Stubbs MT, Morenweiser R, Sturzebecher J, Bauer M, Bode W, Huber R, Piechottka GP, Matschiner G, Sommerhoff CP, Fritz H, Auerswald EA
Title	The three-dimensional structure of recombinant leech-derived tryptase inhibitor in complex with trypsin. Implications for the structure of human mast cell tryptase and its inhibition.
Related PDB	1ldt
Related UniProtKB	P00761
[63]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	9199408
Journal	J Mol Biol
Year	1997
Volume	269
Pages	395-407
Authors	Burgering MJ, Orbons LP, van der Doelen A, Mulders J, Theunissen HJ, Grootenhuis PD, Bode W, Huber R, Stubbs MT
Title	The second Kunitz domain of human tissue factor pathway inhibitor: cloning, structure determination and interaction with factor Xa.
Related PDB	1tfx
Related UniProtKB
[64]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	9300481
Journal	Protein Sci
Year	1997
Volume	6
Pages	1806-24
Authors	Scheidig AJ, Hynes TR, Pelletier LA, Wells JA, Kossiakoff AA
Title	Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.
Related PDB	1taw
Related UniProtKB
[65]
Resource
Comments	X-RAY CRYSTALLOGRAPHY (2.03 ANGSTROMS) OF COMPLEX WITH LDTI.
Medline ID	98046095
PubMed ID	9384562
Journal	Structure
Year	1997
Volume	5
Pages	1465-74
Authors	Di Marco S, Priestle JP
Title	Structure of the complex of leech-derived tryptase inhibitor (LDTI) with trypsin and modeling of the LDTI-tryptase system.
Related PDB	1an1
Related UniProtKB	P00761
[66]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	9757092
Journal	Acta Crystallogr D Biol Crystallogr
Year	1998
Volume	54
Pages	780-98
Authors	Schroder HK, Willassen NP, Smalas AO
Title	Structure of a non-psychrophilic trypsin from a cold-adapted fish species.
Related PDB	1a0j
Related UniProtKB
[67]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	9724521
Journal	Biochemistry
Year	1998
Volume	37
Pages	12094-103
Authors	Krishnan R, Zhang E, Hakansson K, Arni RK, Tulinsky A, Lim-Wilby MS, Levy OE, Semple JE, Brunck TK
Title	Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes.
Related PDB	1yyy 1zzz
Related UniProtKB
[68]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	9836602
Journal	Biochemistry
Year	1998
Volume	37
Pages	17068-81
Authors	Presnell SR, Patil GS, Mura C, Jude KM, Conley JM, Bertrand JA, Kam CM, Powers JC, Williams LD
Title	Oxyanion-mediated inhibition of serine proteases.
Related PDB	1bju 1bjv
Related UniProtKB
[69]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	9920392
Journal	Biochim Biophys Acta
Year	1998
Volume	1429
Pages	142-50
Authors	Zhu G, Huang Q, Wang Z, Qian M, Jia Y, Tang Y
Title	X-ray studies on two forms of bovine beta-trypsin crystals in neat cyclohexane.
Related PDB	1tio 2tio
Related UniProtKB
[70]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	9760170
Journal	Eur J Biochem
Year	1998
Volume	256
Pages	317-24
Authors	Helland R, Leiros I, Berglund GI, Willassen NP, Smalas AO
Title	The crystal structure of anionic salmon trypsin in complex with bovine pancreatic trypsin inhibitor.
Related PDB	1bzx
Related UniProtKB
[71]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID
Journal	J Am Chem Soc
Year	1998
Volume	120
Pages	595-6
Authors	Sandler B, Murakami M, Clardy J
Title	Atomic Structure of the Trypsin-Aeruginosin 98-B Complex.
Related PDB	1aq7
Related UniProtKB
[72]
Resource
Comments
Medline ID
PubMed ID	9876114
Journal	J Med Chem
Year	1998
Volume	41
Pages	5445-56
Authors	Renatus M, Bode W, Huber R, Sturzebecher J, Stubbs MT
Title	Structural and functional analyses of benzamidine-based inhibitors in complex with trypsin: implications for the inhibition of factor Xa, tPA, and urokinase.
Related PDB
Related UniProtKB
[73]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	9466914
Journal	J Mol Biol
Year	1998
Volume	275
Pages	347-63
Authors	Song HK, Suh SW
Title	Kunitz-type soybean trypsin inhibitor revisited: refined structure of its complex with porcine trypsin reveals an insight into the interaction between a homologous inhibitor from Erythrina caffra and tissue-type plasminogen activator.
Related PDB	1avw 1avx
Related UniProtKB
[74]
Resource
Comments
Medline ID
PubMed ID	9495588
Journal	J Pept Res
Year	1998
Volume	51
Pages	29-37
Authors	Bemquerer MP, Liria CW, Kitagawa K, Miranda MT, Tominaga M
Title	Mixtures of trifluoroethanol or hexafluoroisopropanol and dimethylformamide are not of general applicability for peptide condensations catalyzed by trypsin.
Related PDB
Related UniProtKB
[75]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	9468142
Journal	Nature
Year	1998
Volume	391
Pages	608-12
Authors	Katz BA, Clark JM, Finer-Moore JS, Jenkins TE, Johnson CR, Ross MJ, Luong C, Moore WR, Stroud RM
Title	Design of potent selective zinc-mediated serine protease inhibitors.
Related PDB	1c1n 1c1o 1c1p 1c1q 1c1r 1c1s 1c1t 1c2d 1c2e 1c2f 1c2g 1c2h 1c2i 1c2j 1c2k 1c2l 1c2m 1xuf 1xug 1xuh 1xui 1xuj 1xuk
Related UniProtKB
[76]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	9707558
Journal	Proc Natl Acad Sci U S A
Year	1998
Volume	95
Pages	9813-8
Authors	Hopfner KP, Kopetzki E, Kresse GB, Bode W, Huber R, Engh RA
Title	New enzyme lineages by subdomain shuffling.
Related PDB	1fxy
Related UniProtKB
[77]
Resource
Comments
Medline ID
PubMed ID	9749919
Journal	Protein Eng
Year	1998
Volume	11
Pages	669-73
Authors	Hung SH, Hedstrom L
Title	Converting trypsin to elastase: substitution of the S1 site and adjacent loops reconstitutes esterase specificity but not amidase activity.
Related PDB
Related UniProtKB
[78]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	10089404
Journal	Acta Crystallogr D Biol Crystallogr
Year	1999
Volume	55
Pages	139-48
Authors	Helland R, Berglund GI, Otlewski J, Apostoluk W, Andersen OA, Willassen NP, Smalas AO
Title	High-resolution structures of three new trypsin-squash-inhibitor complexes: a detailed comparison with other trypsins and their complexes.
Related PDB	2btc 2sta 2stb
Related UniProtKB
[79]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	10531473
Journal	Acta Crystallogr D Biol Crystallogr
Year	1999
Volume	55
Pages	1785-91
Authors	Recacha R, Carson M, Costanzo MJ, Maryanoff B, DeLucas LJ, Chattopadhyay D
Title	Structure of the RWJ-51084-bovine pancreatic beta-trypsin complex at 1.8 A.
Related PDB	1qcp
Related UniProtKB
[80]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	10417407
Journal	Acta Crystallogr D Biol Crystallogr
Year	1999
Volume	55
Pages	1395-404
Authors	Whitlow M, Arnaiz DO, Buckman BO, Davey DD, Griedel B, Guilford WJ, Koovakkat SK, Liang A, Mohan R, Phillips GB, Seto M, Shaw KJ, Xu W, Zhao Z, Light DR, Morrissey MM
Title	Crystallographic analysis of potent and selective factor Xa inhibitors complexed to bovine trypsin.
Related PDB	1qa0 1qb1 1qb6 1qb9 1qbn 1qbo
Related UniProtKB
[81]
Resource
Comments
Medline ID
PubMed ID	9989934
Journal	Arch Biochem Biophys
Year	1999
Volume	362
Pages	254-64
Authors	Kaslik G, Westler WM, Graf L, Markley JL
Title	Properties of the His57-Asp102 dyad of rat trypsin D189S in the zymogen, activated enzyme, and alpha1-proteinase inhibitor complexed forms.
Related PDB
Related UniProtKB
[82]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	10561533
Journal	Biochim Biophys Acta
Year	1999
Volume	1435
Pages	7-21
Authors	Johnson A, Gautham N, Pattabhi V
Title	Crystal structure at 1.63 A resolution of the native form of porcine beta-trypsin: revealing an acetate ion binding site and functional water network.
Related PDB	1qqu
Related UniProtKB
[83]
Resource
Comments
Medline ID
PubMed ID	10429182
Journal	Eur J Biochem
Year	1999
Volume	263
Pages	20-6
Authors	Szabo E, Bocskei Z, Naray-Szabo G, Graf L
Title	The three-dimensional structure of Asp189Ser trypsin provides evidence for an inherent structural plasticity of the protease.
Related PDB
Related UniProtKB
[84]
Resource
Comments
Medline ID
PubMed ID	10641732
Journal	Free Radic Biol Med
Year	1999
Volume	27
Pages	1378-85
Authors	Finotti P, Corvaja C, Pagetta A
Title	Differential mechanisms for structural and functional alterations of trypsin by heparin, evidence for a specific, radical-generating mechanism at low heparin concentrations.
Related PDB
Related UniProtKB
[85]
Resource
Comments
Medline ID
PubMed ID	10517520
Journal	Int J Biol Macromol
Year	1999
Volume	26
Pages	135-44
Authors	Finotti P, Pagetta A, Corvaja C
Title	Role of reducing terminals in unfractionated and low-molecular-mass heparins in causing free radical generation and loss of structure and activity of trypsin.
Related PDB
Related UniProtKB
[86]
Resource
Comments
Medline ID
PubMed ID	10373424
Journal	J Biol Chem
Year	1999
Volume	274
Pages	18231-6
Authors	Lin CY, Anders J, Johnson M, Sang QA, Dickson RB
Title	Molecular cloning of cDNA for matriptase, a matrix-degrading serine protease with trypsin-like activity.
Related PDB
Related UniProtKB
[87]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	10447205
Journal	J Biomol Struct Dyn
Year	1999
Volume	16
Pages	1219-24
Authors	Zhu Y, Huang Q, Chi C
Title	Crystal structure of mung bean inhibitor lysine active fragment complex with bovine beta-trypsin at 1.8A resolution.
Related PDB	1sbw
Related UniProtKB
[88]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	10222201
Journal	J Mol Biol
Year	1999
Volume	287
Pages	923-42
Authors	Helland R, Otlewski J, Sundheim O, Dadlez M, Smalas AO
Title	The crystal structures of the complexes between bovine beta-trypsin and ten P1 variants of BPTI.
Related PDB	3btd 3bte 3btf 3btg 3bth 3btk 3btm 3btq 3btt 3btw
Related UniProtKB
[89]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	10390350
Journal	J Mol Biol
Year	1999
Volume	290
Pages	525-33
Authors	Luckett S, Garcia RS, Barker JJ, Konarev AV, Shewry PR, Clarke AR, Brady RL
Title	High-resolution structure of a potent, cyclic proteinase inhibitor from sunflower seeds.
Related PDB	1sfi
Related UniProtKB
[90]
Resource
Comments
Medline ID
PubMed ID	10356328
Journal	J Mol Biol
Year	1999
Volume	289
Pages	547-64
Authors	Nakasako M
Title	Large-scale networks of hydration water molecules around bovine beta-trypsin revealed by cryogenic X-ray crystal structure analysis.
Related PDB
Related UniProtKB
[91]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	10512718
Journal	J Mol Biol
Year	1999
Volume	293
Pages	93-106
Authors	Rester U, Bode W, Moser M, Parry MA, Huber R, Auerswald E
Title	Structure of the complex of the antistasin-type inhibitor bdellastasin with trypsin and modelling of the bdellastasin-microplasmin system.
Related PDB	1c9p 1c9t
Related UniProtKB
[92]
Resource
Comments
Medline ID
PubMed ID	10591040
Journal	J Nat Toxins
Year	1999
Volume	8
Pages	363-84
Authors	Azim MK, Grossmann JG, Zaidi ZH
Title	Predicted three-dimensional structural models of venom serine protease inhibitors and their interactions with trypsin and chymotrypsin.
Related PDB
Related UniProtKB
[93]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	10524768
Journal	J Protein Chem
Year	1999
Volume	18
Pages	505-9
Authors	Zhu Y, Huang Q, Qian M, Jia Y, Tang Y
Title	Crystal structure of the complex formed between bovine beta-trypsin and MCTI-A, a trypsin inhibitor of squash family, at 1.8-A resolution.
Related PDB	1f2s 1mcu
Related UniProtKB
[94]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	10210204
Journal	Protein Sci
Year	1999
Volume	8
Pages	253-8
Authors	Pasternak A, Ringe D, Hedstrom L
Title	Comparison of anionic and cationic trypsinogens: the anionic activation domain is more flexible in solution and differs in its mode of BPTI binding in the crystal structure.
Related PDB	3tgi 3tgj
Related UniProtKB
[95]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	10651279
Journal	Proteins
Year	1999
Volume	37
Pages	641-53
Authors	Ota N, Stroupe C, Ferreira-da-Silva JM, Shah SA, Mares-Guia M, Brunger AT
Title	Non-Boltzmann thermodynamic integration (NBTI) for macromolecular systems: relative free energy of binding of trypsin to benzamidine and benzylamine.
Related PDB	1ce5 2bza
Related UniProtKB
[96]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	10771427
Journal	Acta Crystallogr D Biol Crystallogr
Year	2000
Volume	56
Pages	581-8
Authors	Rester U, Moser M, Huber R, Bode W
Title	L-Isoaspartate 115 of porcine beta-trypsin promotes crystallization of its complex with bdellastasin.
Related PDB	1eja
Related UniProtKB
[97]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	10779411
Journal	Chem Biol
Year	2000
Volume	7
Pages	299-312
Authors	Katz BA, Mackman R, Luong C, Radika K, Martelli A, Sprengeler PA, Wang J, Chan H, Wong L
Title	Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
Related PDB	1c5p 1c5q 1c5r 1c5s 1c5t 1c5u 1c5v
Related UniProtKB
[98]
Resource
Comments
Medline ID
PubMed ID	11126764
Journal	Comp Biochem Physiol B Biochem Mol Biol
Year	2000
Volume	127
Pages	337-46
Authors	Sekizaki H, Itoh K, Murakami M, Toyota E, Tanizawa K
Title	Anionic trypsin from chum salmon: activity with p-amidinophenyl ester and comparison with bovine and Streptomyces griseus trypsins.
Related PDB
Related UniProtKB
[99]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	10966741
Journal	J Med Chem
Year	2000
Volume	43
Pages	3226-32
Authors	Maignan S, Guilloteau JP, Pouzieux S, Choi-Sledeski YM, Becker MR, Klein SI, Ewing WR, Pauls HW, Spada AP, Mikol V
Title	Crystal structures of human factor Xa complexed with potent inhibitors.
Related PDB	1f0t 1f0u
Related UniProtKB
[100]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	10843853
Journal	J Mol Biol
Year	2000
Volume	299
Pages	993-1003
Authors	Gillmor SA, Takeuchi T, Yang SQ, Craik CS, Fletterick RJ
Title	Compromise and accommodation in ecotin, a dimeric macromolecular inhibitor of serine proteases.
Related PDB	1ezs 1ezu
Related UniProtKB
[101]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	10926503
Journal	J Mol Biol
Year	2000
Volume	301
Pages	205-17
Authors	Grzesiak A, Helland R, Smalas AO, Krowarsch D, Dadlez M, Otlewski J
Title	Substitutions at the P(1) position in BPTI strongly affect the association energy with serine proteinases.
Related PDB	1ejm
Related UniProtKB
[102]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	10772864
Journal	J Mol Biol
Year	2000
Volume	298
Pages	477-91
Authors	Koepke J, Ermler U, Warkentin E, Wenzl G, Flecker P
Title	Crystal structure of cancer chemopreventive Bowman-Birk inhibitor in ternary complex with bovine trypsin at 2.3 A resolution. Structural basis of Janus-faced serine protease inhibitor specificity.
Related PDB	1d6r
Related UniProtKB
[103]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	11057674
Journal	Nature
Year	2000
Volume	407
Pages	923-6
Authors	Huntington JA, Read RJ, Carrell RW
Title	Structure of a serpin-protease complex shows inhibition by deformation.
Related PDB	1ezx
Related UniProtKB
[104]
Resource
Comments
Medline ID
PubMed ID	10944388
Journal	Proteins
Year	2000
Volume	41
Pages	8-16
Authors	Pletnev VZ, Zamolodchikova TS, Pangborn WA, Duax WL
Title	Crystal structure of bovine duodenase, a serine protease, with dual trypsin and chymotrypsin-like specificities.
Related PDB
Related UniProtKB
[105]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	11679713
Journal	Acta Crystallogr D Biol Crystallogr
Year	2001
Volume	57
Pages	1506-12
Authors	Deepthi S, Johnson A, Pattabhi V
Title	Structures of porcine beta-trypsin-detergent complexes: the stabilization of proteins through hydrophilic binding of polydocanol.
Related PDB	1fmg 1fn6 1fni
Related UniProtKB
[106]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	11264577
Journal	Acta Crystallogr D Biol Crystallogr
Year	2001
Volume	57
Pages	488-97
Authors	Leiros HK, McSweeney SM, Smalas AO
Title	Atomic resolution structures of trypsin provide insight into structural radiation damage.
Related PDB	1hj8 1hj9
Related UniProtKB
[107]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	11134922
Journal	Acta Crystallogr D Biol Crystallogr
Year	2001
Volume	57
Pages	8-19
Authors	Rypniewski WR, Ostergaard PR, Norregaard-Madsen M, Dauter M, Wilson KS
Title	Fusarium oxysporum trypsin at atomic resolution at 100 and 283 K: a study of ligand binding.
Related PDB	1fn8 1fy4 1fy5 1gdn 1gdq 1gdu
Related UniProtKB
[108]
Resource
Comments
Medline ID
PubMed ID	11371189
Journal	Biochemistry
Year	2001
Volume	40
Pages	6275-83
Authors	Peterson FC, Gordon NC, Gettins PG
Title	High-level bacterial expression and 15N-alanine-labeling of bovine trypsin. Application to the study of trypsin-inhibitor complexes and trypsinogen activation by NMR spectroscopy.
Related PDB
Related UniProtKB
[109]
Resource
Comments
Medline ID
PubMed ID	11731085
Journal	Biochim Biophys Acta
Year	2001
Volume	1568
Pages	53-9
Authors	Park H, Chi YM
Title	The enhancement of electrostriction caused by lowering the solvent dielectric constant leads to the decrease of activation energy in trypsin catalysis.
Related PDB
Related UniProtKB
[110]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	11731301
Journal	Chem Biol
Year	2001
Volume	8
Pages	1107-21
Authors	Katz BA, Sprengeler PA, Luong C, Verner E, Elrod K, Kirtley M, Janc J, Spencer JR, Breitenbucher JG, Hui H, McGee D, Allen D, Martelli A, Mackman RL
Title	Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets.
Related PDB	1gj6
Related UniProtKB
[111]
Resource
Comments
Medline ID
PubMed ID	11508835
Journal	Eur Biophys J
Year	2001
Volume	30
Pages	163-70
Authors	Caracciolo G, Amiconi G, Bencivenni L, Boumis G, Caminiti R, Finocchiaro E, Maras B, Paolinelli C, Congiu Castellano A
Title	Conformational study of proteins by SAXS and EDXD: the case of trypsin and trypsinogen.
Related PDB
Related UniProtKB
[112]
Resource
Comments
Medline ID
PubMed ID	11226886
Journal	J Biochem (Tokyo)
Year	2001
Volume	129
Pages	455-60
Authors	Tomoo K, Satoh K, Tsuda Y, Wanaka K, Okamoto S, Hijikata-Okunomiya A, Okada Y, Ishida T
Title	Binding diversity of a noncovalent-type low-molecular-weight serine protease inhibitor and function of a catalytic water molecule: X-ray crystal structure of PKSI-527--inhibited trypsin.
Related PDB
Related UniProtKB
[113]
Resource
Comments
Medline ID
PubMed ID	11312265
Journal	J Biol Chem
Year	2001
Volume	276
Pages	24574-80
Authors	Szilagyi L, Kenesi E, Katona G, Kaslik G, Juhasz G, Graf L
Title	Comparative in vitro studies on native and recombinant human cationic trypsins. Cathepsin B is a possible pathological activator of trypsinogen in pancreatitis.
Related PDB
Related UniProtKB
[114]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	11676542
Journal	J Mol Biol
Year	2001
Volume	313
Pages	593-614
Authors	Dullweber F, Stubbs MT, Musil D, Sturzebecher J, Klebe G
Title	Factorising ligand affinity: a combined thermodynamic and crystallographic study of trypsin and thrombin inhibition.
Related PDB	1k1i 1k1j 1k1l 1k1m 1k1n 1k1o 1k1p
Related UniProtKB
[115]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	11292354
Journal	J Mol Biol
Year	2001
Volume	307
Pages	1451-86
Authors	Katz BA, Elrod K, Luong C, Rice MJ, Mackman RL, Sprengeler PA, Spencer J, Hataye J, Janc J, Link J, Litvak J, Rai R, Rice K, Sideris S, Verner E, Young W
Title	A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.
Related PDB	1ghz 1gi0 1gi1 1gi2 1gi3 1gi4 1gi5 1gi6
Related UniProtKB
[116]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	11152605
Journal	J Mol Biol
Year	2001
Volume	305
Pages	471-9
Authors	Toyota E, Ng KK, Sekizaki H, Itoh K, Tanizawa K, James MN
Title	X-ray crystallographic analyses of complexes between bovine beta-trypsin and Schiff base copper(II) or iron(III) chelates.
Related PDB	1g3b 1g3c 1g3d 1g3e
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[117]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	11685246
Journal	Nat Struct Biol
Year	2001
Volume	8
Pages	979-83
Authors	Ye S, Cech AL, Belmares R, Bergstrom RC, Tong Y, Corey DR, Kanost MR, Goldsmith EJ
Title	The structure of a Michaelis serpin-protease complex.
Related PDB	1i99 1k9o
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[118]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	11420435
Journal	Protein Sci
Year	2001
Volume	10
Pages	1331-42
Authors	Pasternak A, White A, Jeffery CJ, Medina N, Cahoon M, Ringe D, Hedstrom L
Title	The energetic cost of induced fit catalysis: Crystal structures of trypsinogen mutants with enhanced activity and inhibitor affinity.
Related PDB	1fy8 1f5r 1f7z 3tgk
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[119]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	11342132
Journal	Structure (Camb)
Year	2001
Volume	9
Pages	29-37
Authors	Nar H, Bauer M, Schmid A, Stassen JM, Wienen W, Priepke HW, Kauffmann IK, Ries UJ, Hauel NH
Title	Structural basis for inhibition promiscuity of dual specific thrombin and factor Xa blood coagulation inhibitors.
Related PDB	1g36 1oyq
Related UniProtKB
[120]
Resource
Comments
Medline ID
PubMed ID	11779198
Journal	Biochem Biophys Res Commun
Year	2002
Volume	290
Pages	494-7
Authors	Marana SR, Lopes AR, Juliano L, Juliano MA, Ferreira C, Terra WR
Title	Subsites of trypsin active site favor catalysis or substrate binding.
Related PDB
Related UniProtKB
[121]
Resource
Comments
Medline ID
PubMed ID	11921406
Journal	Chembiochem
Year	2002
Volume	3
Pages	246-9
Authors	Stubbs MT, Reyda S, Dullweber F, Moller M, Klebe G, Dorsch D, Mederski WW, Wurziger H
Title	pH-dependent binding modes observed in trypsin crystals: lessons for structure-based drug design.
Related PDB	1ql7 1ql8 1ql9
Related UniProtKB
[122]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	12061878
Journal	J Med Chem
Year	2002
Volume	45
Pages	2749-69
Authors	Matter H, Defossa E, Heinelt U, Blohm PM, Schneider D, Muller A, Herok S, Schreuder H, Liesum A, Brachvogel V, Lonze P, Walser A, Al-Obeidi F, Wildgoose P
Title	Design and quantitative structure-activity relationship of 3-amidinobenzyl-1H-indole-2-carboxamides as potent, nonchiral, and selective inhibitors of blood coagulation factor Xa.
Related PDB	1lqe
Related UniProtKB
[123]
Resource
Comments
Medline ID
PubMed ID	11827488
Journal	J Mol Biol
Year	2002
Volume	315
Pages	1209-18
Authors	Katona G, Berglund GI, Hajdu J, Graf L, Szilagyi L
Title	Crystal structure reveals basis for the inhibitor resistance of human brain trypsin.
Related PDB
Related UniProtKB
[124]
Resource
Comments
Medline ID
PubMed ID	12445776
Journal	J Mol Biol
Year	2002
Volume	324
Pages	391-7
Authors	Toyota E, Ng KK, Kuninaga S, Sekizaki H, Itoh K, Tanizawa K, James MN
Title	Crystal structure and nucleotide sequence of an anionic trypsin from chum salmon (Oncorhynchus keta) in comparison with Atlantic salmon (Salmo salar) and bovine trypsin.
Related PDB
Related UniProtKB
[125]
Resource
Comments
Medline ID
PubMed ID	12705877
Journal	Biochem Biophys Res Commun
Year	2003
Volume	304
Pages	18-21
Authors	Kotorman M, Laczko I, Szabo A, Simon LM
Title	Effects of Ca2+ on catalytic activity and conformation of trypsin and alpha-chymotrypsin in aqueous ethanol.
Related PDB
Related UniProtKB
[126]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	12885239
Journal	Biochemistry
Year	2003
Volume	42
Pages	9060-6
Authors	Page MJ, Wong SL, Hewitt J, Strynadka NC, MacGillivray RT
Title	Engineering the primary substrate specificity of Streptomyces griseus trypsin.
Related PDB	1os8 1oss
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[127]
Resource
Comments
Medline ID
PubMed ID	12837799
Journal	J Bacteriol
Year	2003
Volume	185
Pages	4233-42
Authors	Sudom A, Walters R, Pastushok L, Goldie D, Prasad L, Delbaere LT, Goldie H
Title	Mechanisms of activation of phosphoenolpyruvate carboxykinase from Escherichia coli by Ca2+ and of desensitization by trypsin.
Related PDB
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[128]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	12860985
Journal	J Biol Chem
Year	2003
Volume	278
Pages	37881-7
Authors	Dementiev A, Simonovic M, Volz K, Gettins PG
Title	Canonical inhibitor-like interactions explain reactivity of alpha1-proteinase inhibitor Pittsburgh and antithrombin with proteinases.
Related PDB	1oph
Related UniProtKB
[129]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	12937176
Journal	J Biol Chem
Year	2003
Volume	278
Pages	43357-62
Authors	Schmidt A, Jelsch C, Ostergaard P, Rypniewski W, Lamzin VS
Title	Trypsin revisited: crystallography AT (SUB) atomic resolution and quantum chemistry revealing details of catalysis.
Related PDB	1ppz 1pq5 1pq7 1pq8 1pqa
Related UniProtKB
[130]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	12930148
Journal	J Med Chem
Year	2003
Volume	46
Pages	3865-76
Authors	Costanzo MJ, Yabut SC, Almond HR Jr, Andrade-Gordon P, Corcoran TW, De Garavilla L, Kauffman JA, Abraham WM, Recacha R, Chattopadhyay D, Maryanoff BE
Title	Potent, small-molecule inhibitors of human mast cell tryptase. Antiasthmatic action of a dipeptide-based transition-state analogue containing a benzothiazole ketone.
Related PDB	1nc6
Related UniProtKB
[131]
Resource
Comments
Medline ID
PubMed ID	14568540
Journal	J Mol Biol
Year	2003
Volume	333
Pages	845-61
Authors	Helland R, Czapinska H, Leiros I, Olufsen M, Otlewski J, Smalas AO
Title	Structural consequences of accommodation of four non-cognate amino acid residues in the S1 pocket of bovine trypsin and chymotrypsin.
Related PDB
Related UniProtKB
[132]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	12742021
Journal	J Mol Biol
Year	2003
Volume	329
Pages	93-120
Authors	Katz BA, Elrod K, Verner E, Mackman RL, Luong C, Shrader WD, Sendzik M, Spencer JR, Sprengeler PA, Kolesnikov A, Tai VW, Hui HC, Breitenbucher JG, Allen D, Janc JW
Title	Elaborate manifold of short hydrogen bond arrays mediating binding of active site-directed serine protease inhibitors.
Related PDB	1o2h 1o2i 1o2j 1o2k 1o2l 1o2m 1o2n 1o2o 1o2p 1o2q 1o2r 1o2s 1o2t 1o2u 1o2v 1o2w 1o2x 1o2y 1o2z 1o30 1o31 1o32 1o33 1o34 1o35 1o36 1o37 1o38 1o39 1o3a 1o3b 1o3c 1o3d 1o3e 1o3f 1o3g 1o3h 1o3i 1o3j 1o3k 1o3l 1o3m 1o3n 1o3o
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[133]
Resource
Comments
Medline ID
PubMed ID	12527302
Journal	J Mol Biol
Year	2003
Volume	325
Pages	963-77
Authors	Reyda S, Sohn C, Klebe G, Rall K, Ullmann D, Jakubke HD, Stubbs MT
Title	Reconstructing the binding site of factor Xa in trypsin reveals ligand-induced structural plasticity.
Related PDB	1j14 1j15 1j16 1j17
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[134]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	12575941
Journal	Structure (Camb)
Year	2003
Volume	11
Pages	217-24
Authors	Ravelli RB, Leiros HK, Pan B, Caffrey M, McSweeney S
Title	Specific radiation damage can be used to solve macromolecular crystal structures.
Related PDB	1n6x 1n6y
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[135]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	14672690
Journal	Biochem Biophys Res Commun
Year	2004
Volume	313
Pages	8-16
Authors	Ibrahim BS, Pattabhi V
Title	Crystal structure of trypsin-turkey egg white inhibitor complex.
Related PDB	1r0t
Related UniProtKB
[136]
Resource
Comments
Medline ID
PubMed ID	14729347
Journal	J Mol Biol
Year	2004
Volume	335
Pages	1325-41
Authors	Rauh D, Klebe G, Stubbs MT
Title	Understanding protein-ligand interactions: the price of protein flexibility.
Related PDB
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[137]
Resource
Comments	X-ray crystallography
Medline ID
PubMed ID	15044735
Journal	Protein Sci
Year	2004
Volume	13
Pages	1056-70
Authors	Leiros HK, Brandsdal BO, Andersen OA, Os V, Leiros I, Helland R, Otlewski J, Willassen NP, Smalas AO
Title	Trypsin specificity as elucidated by LIE calculations, X-ray structures, and association constant measurements.
Related PDB	1utj 1utk 1utl 1utm 1utn 1uto 1utp 1utq
Related UniProtKB

Comments

The chains of the enzymes deposited in the following PDB structures are split into two or three fragments. PDB;1aksA, Swiss-prot;TRYP_PIG;P00761, residues 9-133 (PDB;16-145) PDB;1aksB, Swiss-prot;TRYP_PIG;P00761, residues 134-231 (PDB;146-245) PDB;1eptA, Swiss-prot;TRYP_PIG;P00761, residues 9-51 (PDB;16-60) PDB;1eptB, Swiss-prot;TRYP_PIG;P00761, residues 52-133 (PDB;61-145) PDB;1eptC, Swiss-prot;TRYP_PIG;P00761, residues 132-231 (PDB;146-245) This enzyme, trypsin, is a calssical serine protease, whose catalytic mechanism has been elucidated by various studies. This enzyme has got a catalytic triad, composed of Ser195/His57/Asp102. According to the literature [10] and [53], the catalytic reaction proceeds as follows: (1) His57 acts as a general base, by abstracting a proton from the hydroxyl group of Ser195. Here, Asp102 stabilizes the charged His57, and orients the conformation of His57 correctly (see [10]). (2) Ser195, whose nucleophilicity was enhanced by His57, makes a nucleophilic attack on the carbonyl carbon atom of the scissile bond, peptide bond, leading to the formation of a tetrahedral acyl-intermediate. (3) The oxyanion of the intermediate is stabilized by the mainchain amide nitrogens of Gly193 and Ser195. (4) His57 acts as a general acid, by protonating to the newly formed amine group. This leads to the dissociation of the first product. (5) A water molecule makes a nucleophilic attack on the acyl group, resulting in the deacylation.

Created	Updated
2004-09-17	2021-04-21