DB code: D00005
| CATH domain | 3.40.50.720 : Rossmann fold | Catalytic domain |
|---|---|---|
| 3.90.110.10 : L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2 | Catalytic domain | |
| E.C. | 1.1.1.27 | |
| CSA | 1ldm | |
| M-CSA | 1ldm | |
| MACiE | ||
| CATH domain | Related DB codes (homologues) |
|---|---|
| 3.40.50.720 : Rossmann fold | S00543 S00551 S00552 S00553 S00602 S00604 S00605 S00608 S00610 S00625 S00319 S00328 S00329 S00330 S00331 S00332 D00456 D00457 D00458 S00324 S00320 S00325 S00326 S00327 D00459 S00335 S00336 S00334 T00219 S00339 D00513 D00001 D00002 D00003 D00007 D00008 D00010 D00012 D00017 D00018 D00023 D00027 D00028 D00031 D00032 D00033 D00034 D00035 D00037 D00048 D00071 D00476 D00481 D00482 D00490 D00492 D00494 D00545 D00601 D00603 D00604 D00605 D00615 D00845 D00857 D00858 M00161 M00171 M00210 T00002 T00010 T00011 T00015 T00227 T00247 T00408 T00414 D00827 D00262 D00274 D00275 M00035 T00109 |
| 3.90.110.10 : L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2 | D00008 M00171 D00827 |
| Uniprot Enzyme Name | UniprotKB | Protein name | Synonyms | Pfam | RefSeq |
|---|---|---|---|---|
| P00343 |
L-lactate dehydrogenase
|
L-LDH
EC 1.1.1.27 |
PF02866
(Ldh_1_C)
PF00056 (Ldh_1_N) [Graphical View] |
|
| P00344 |
L-lactate dehydrogenase
|
L-LDH
EC 1.1.1.27 |
PF02866
(Ldh_1_C)
PF00056 (Ldh_1_N) [Graphical View] |
|
| P16115 |
L-lactate dehydrogenase
|
L-LDH
EC 1.1.1.27 |
PF02866
(Ldh_1_C)
PF00056 (Ldh_1_N) [Graphical View] |
NP_229663.1
(Protein)
NC_000853.1 (DNA/RNA sequence) |
| E8ME30 |
|
None |
PF02866
(Ldh_1_C)
PF00056 (Ldh_1_N) [Graphical View] |
YP_004221049.1
(Protein)
NC_015067.1 (DNA/RNA sequence) |
| Q27743 |
L-lactate dehydrogenase
|
EC
1.1.1.27
LDH-P |
PF02866
(Ldh_1_C)
PF00056 (Ldh_1_N) [Graphical View] |
|
| P00341 |
L-lactate dehydrogenase A chain
|
LDH-A
EC 1.1.1.27 LDH-M |
PF02866
(Ldh_1_C)
PF00056 (Ldh_1_N) [Graphical View] |
|
| P00339 |
L-lactate dehydrogenase A chain
|
LDH-A
EC 1.1.1.27 LDH muscle subunit LDH-M |
PF02866
(Ldh_1_C)
PF00056 (Ldh_1_N) [Graphical View] |
|
| P00336 |
L-lactate dehydrogenase B chain
|
LDH-B
EC 1.1.1.27 LDH heart subunit LDH-H |
PF02866
(Ldh_1_C)
PF00056 (Ldh_1_N) [Graphical View] |
NP_001106758.1
(Protein)
NM_001113287.1 (DNA/RNA sequence) |
| P00342 |
L-lactate dehydrogenase C chain
|
LDH-C
EC 1.1.1.27 LDH testis subunit LDH-X |
PF02866
(Ldh_1_C)
PF00056 (Ldh_1_N) [Graphical View] |
NP_038608.1
(Protein)
NM_013580.4 (DNA/RNA sequence) |
| P00338 |
L-lactate dehydrogenase A chain
|
LDH-A
EC 1.1.1.27 LDH muscle subunit LDH-M Renal carcinoma antigen NY-REN-59 Cell proliferation-inducing gene 19 protein |
PF02866
(Ldh_1_C)
PF00056 (Ldh_1_N) [Graphical View] |
NP_001128711.1
(Protein)
NM_001135239.1 (DNA/RNA sequence) NP_001158886.1 (Protein) NM_001165414.1 (DNA/RNA sequence) NP_001158887.1 (Protein) NM_001165415.1 (DNA/RNA sequence) NP_001158888.1 (Protein) NM_001165416.1 (DNA/RNA sequence) NP_005557.1 (Protein) NM_005566.3 (DNA/RNA sequence) |
| P07195 |
L-lactate dehydrogenase B chain
|
LDH-B
EC 1.1.1.27 LDH heart subunit LDH-H Renal carcinoma antigen NY-REN-46 |
PF02866
(Ldh_1_C)
PF00056 (Ldh_1_N) [Graphical View] |
NP_001167568.1
(Protein)
NM_001174097.1 (DNA/RNA sequence) NP_002291.1 (Protein) NM_002300.6 (DNA/RNA sequence) |
| KEGG enzyme name |
|---|
|
L-lactate dehydrogenase
lactic acid dehydrogenase L(+)-nLDH L-(+)-lactate dehydrogenase L-lactic dehydrogenase L-lactic acid dehydrogenase lactate dehydrogenase lactate dehydrogenase NAD+-dependent lactic dehydrogenase NAD+-lactate dehydrogenase |
| UniprotKB: Accession Number | Entry name | Activity | Subunit | Subcellular location | Cofactor |
|---|---|---|---|---|---|
| P00344 | LDH_BACST | (S)-lactate + NAD(+) = pyruvate + NADH. | Homotetramer. | Cytoplasm. | |
| P00343 | LDH_LACCA | (S)-lactate + NAD(+) = pyruvate + NADH. | Homotetramer. | Cytoplasm. | |
| P16115 | LDH_THEMA | (S)-lactate + NAD(+) = pyruvate + NADH. | Homotetramer. | Cytoplasm. | |
| E8ME30 | LDH2_BIFL2 | (S)-lactate + NAD(+) = pyruvate + NADH. | Homotetramer (By similarity). | Cytoplasm (By similarity). | |
| Q27743 | LDH_PLAFD | (S)-lactate + NAD(+) = pyruvate + NADH. | Homotetramer. | ||
| P00341 | LDHA_SQUAC | (S)-lactate + NAD(+) = pyruvate + NADH. | Homotetramer. | Cytoplasm. | |
| P00339 | LDHA_PIG | (S)-lactate + NAD(+) = pyruvate + NADH. | Homotetramer. | Cytoplasm. | |
| P00336 | LDHB_PIG | (S)-lactate + NAD(+) = pyruvate + NADH. | Homotetramer. | Cytoplasm. | |
| P00342 | LDHC_MOUSE | (S)-lactate + NAD(+) = pyruvate + NADH. | Homotetramer. | Cytoplasm. | |
| P00338 | LDHA_HUMAN | (S)-lactate + NAD(+) = pyruvate + NADH. | Homotetramer. | Cytoplasm. | |
| P07195 | LDHB_HUMAN | (S)-lactate + NAD(+) = pyruvate + NADH. | Homotetramer. | Cytoplasm. |
| KEGG Pathways | Map code | Pathways | E.C. |
|---|---|---|
| MAP00010 | Glycolysis / Gluconeogenesis | |
| MAP00272 | Cysteine metabolism | |
| MAP00620 | Pyruvate metabolism | |
| MAP00640 | Propanoate metabolism |
| Compound table | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Substrates | Products | Intermediates | |||||||||
| KEGG-id | C00186 | C00003 | C00022 | C00004 | C00080 | ||||||
| E.C. | |||||||||||
| Compound | (S)-Lactate | NAD+ | Pyruvate | NADH | H+ | ||||||
| Type | carbohydrate,carboxyl group | amide group,amine group,nucleotide | carbohydrate,carboxyl group | amide group,amine group,nucleotide | others | ||||||
| ChEBI |
422 422 |
15846 15846 |
32816 32816 |
16908 16908 |
15378 15378 |
||||||
| PubChem |
107689 107689 |
5893 5893 |
1060 1060 |
439153 439153 |
1038 1038 |
||||||
| 1ldbA01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | ||
| 1ldnA01 |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1ldnB01 |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1ldnC01 |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1ldnD01 |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1ldnE01 |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1ldnF01 |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1ldnG01 |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1ldnH01 |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 2ldbA01 |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1llcA01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | ||
| 1a5zA01 |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1lldA01 |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1lldB01 |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1lthR01 |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1lthT01 |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1ceqA01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | ||
| 1cetA01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | ||
| 1ldgA01 |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1t24A01 |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1t25A01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | ||
| 1t26A01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Bound:NAI | ||
| 1t2cA01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Bound:NAI | ||
| 1t2dA01 |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Bound:NAI | ||
| 1t2eA01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | ||
| 1u4oA01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Bound:NAI | ||
| 1u4sA01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | ||
| 1u5aA01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | ||
| 1u5cA01 |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1xivA01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | ||
| 2a94A01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | ||
| 1ldmA01 |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Analogue:AP0 | ||
| 3ldhA01 |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 6ldhA01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | ||
| 8ldhA01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | ||
| 9ldbA01 |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 9ldbB01 |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 9ldtA01 |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 9ldtB01 |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 5ldhA01 |
|
|
|
|
|
Unbound | Analogue:LNC(NAD) | Unbound | Unbound | ||
| 2ldxA01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | ||
| 1i10A01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | ||
| 1i10B01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Bound:NAI | ||
| 1i10C01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Bound:NAI | ||
| 1i10D01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Bound:NAI | ||
| 1i10E01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Bound:NAI | ||
| 1i10F01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Bound:NAI | ||
| 1i10G01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Bound:NAI | ||
| 1i10H01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Bound:NAI | ||
| 1i0zA01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Bound:NAI | ||
| 1i0zB01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Bound:NAI | ||
| 1t2fA01 |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Bound:NAI | ||
| 1t2fB01 |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1t2fC01 |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1t2fD01 |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1ldbA02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | ||
| 1ldnA02 |
|
|
|
|
|
Unbound | Unbound | Analogue:OXM | Unbound | ||
| 1ldnB02 |
|
|
|
|
|
Unbound | Unbound | Analogue:OXM | Unbound | ||
| 1ldnC02 |
|
|
|
|
|
Unbound | Unbound | Analogue:OXM | Unbound | ||
| 1ldnD02 |
|
|
|
|
|
Unbound | Unbound | Analogue:OXM | Unbound | ||
| 1ldnE02 |
|
|
|
|
|
Unbound | Unbound | Analogue:OXM | Unbound | ||
| 1ldnF02 |
|
|
|
|
|
Unbound | Unbound | Analogue:OXM | Unbound | ||
| 1ldnG02 |
|
|
|
|
|
Unbound | Unbound | Analogue:OXM | Unbound | ||
| 1ldnH02 |
|
|
|
|
|
Unbound | Unbound | Analogue:OXM | Unbound | ||
| 2ldbA02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | ||
| 1llcA02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | ||
| 1a5zA02 |
|
|
|
|
|
Unbound | Unbound | Analogue:OXM | Unbound | ||
| 1lldA02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | ||
| 1lldB02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | ||
| 1lthR02 |
|
|
|
|
|
Unbound | Unbound | Analogue:OXM | Unbound | ||
| 1lthT02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | ||
| 1ceqA02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | ||
| 1cetA02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | ||
| 1ldgA02 |
|
|
|
|
|
Unbound | Unbound | Analogue:OXM | Unbound | ||
| 1t24A02 |
|
|
|
|
|
Unbound | Unbound | Analogue:OXQ | Unbound | ||
| 1t25A02 |
|
|
|
|
|
Unbound | Unbound | Analogue:GAG | Unbound | ||
| 1t26A02 |
|
|
|
|
|
Unbound | Unbound | Analogue:GBD | Unbound | ||
| 1t2cA02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | ||
| 1t2dA02 |
|
|
|
|
|
Unbound | Unbound | Analogue:OXL | Unbound | ||
| 1t2eA02 |
|
|
|
|
|
Unbound | Unbound | Analogue:OXM | Unbound | ||
| 1u4oA02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | ||
| 1u4sA02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | ||
| 1u5aA02 |
|
|
|
|
|
Unbound | Unbound | Analogue:BIK | Unbound | ||
| 1u5cA02 |
|
|
|
|
|
Unbound | Unbound | Analogue:BIK | Unbound | ||
| 1xivA02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | ||
| 2a94A02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | ||
| 1ldmA02 |
|
|
|
|
|
Unbound | Unbound | Analogue:OXM | Unbound | ||
| 3ldhA02 |
|
|
|
|
|
Unbound | Unbound | Bound:PYR | Unbound | ||
| 6ldhA02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | ||
| 8ldhA02 |
|
|
|
|
|
Analogue:CIT_1 | Unbound | Unbound | Unbound | ||
| 9ldbA02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | ||
| 9ldbB02 |
|
|
|
|
|
Unbound | Unbound | Analogue:OXM | Unbound | ||
| 9ldtA02 |
|
|
|
|
|
Unbound | Unbound | Analogue:OXM | Unbound | ||
| 9ldtB02 |
|
|
|
|
|
Unbound | Unbound | Analogue:OXM | Unbound | ||
| 5ldhA02 |
|
|
|
|
|
Analogue:LNC(S-lactate) | Unbound | Unbound | Unbound | ||
| 2ldxA02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | ||
| 1i10A02 |
|
|
|
|
|
Unbound | Unbound | Analogue:OXM | Unbound | ||
| 1i10B02 |
|
|
|
|
|
Unbound | Unbound | Analogue:OXM | Unbound | ||
| 1i10C02 |
|
|
|
|
|
Unbound | Unbound | Analogue:OXM | Unbound | ||
| 1i10D02 |
|
|
|
|
|
Unbound | Unbound | Analogue:OXM | Unbound | ||
| 1i10E02 |
|
|
|
|
|
Unbound | Unbound | Analogue:OXM | Unbound | ||
| 1i10F02 |
|
|
|
|
|
Unbound | Unbound | Analogue:OXM | Unbound | ||
| 1i10G02 |
|
|
|
|
|
Unbound | Unbound | Analogue:OXM | Unbound | ||
| 1i10H02 |
|
|
|
|
|
Unbound | Unbound | Analogue:OXM | Unbound | ||
| 1i0zA02 |
|
|
|
|
|
Unbound | Unbound | Analogue:OXM | Unbound | ||
| 1i0zB02 |
|
|
|
|
|
Unbound | Unbound | Analogue:OXM | Unbound | ||
| 1t2fA02 |
|
|
|
|
|
Unbound | Unbound | Analogue:OXQ | Unbound | ||
| 1t2fB02 |
|
|
|
|
|
Unbound | Unbound | Analogue:OXQ | Unbound | ||
| 1t2fC02 |
|
|
|
|
|
Unbound | Unbound | Analogue:OXQ | Unbound | ||
| 1t2fD02 |
|
|
|
|
|
Unbound | Unbound | Analogue:OXQ | Unbound | ||
| Reference for Active-site residues | ||
|---|---|---|
| resource | references | E.C. |
| Swiss-prot;Q27743, P00336, P00339, P00341, P00342, P00344, P00343, P16115, literature [22] | ||
| Active-site residues | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Catalytic residues | Cofactor-binding residues | Modified residues | Main-chain involved in catalysis | Comment | |||||
| 1ldbA01 |
|
|
|
|
|
invisible 100-107 | ||||
| 1ldnA01 |
|
|
|
|
|
ARG 106 | ||||
| 1ldnB01 |
|
|
|
|
|
ARG 106 | ||||
| 1ldnC01 |
|
|
|
|
|
ARG 106 | ||||
| 1ldnD01 |
|
|
|
|
|
ARG 106 | ||||
| 1ldnE01 |
|
|
|
|
|
ARG 106 | ||||
| 1ldnF01 |
|
|
|
|
|
ARG 106 | ||||
| 1ldnG01 |
|
|
|
|
|
ARG 106 | ||||
| 1ldnH01 |
|
|
|
|
|
ARG 106 | ||||
| 2ldbA01 |
|
|
|
|
|
invisible 99-106 | ||||
| 1llcA01 |
|
|
|
|
|
ARG 109 | ||||
| 1a5zA01 |
|
|
|
|
|
ARG 109 | ||||
| 1lldA01 |
|
|
|
|
|
ARG 93 | ||||
| 1lldB01 |
|
|
|
|
|
ARG 93 | ||||
| 1lthR01 |
|
|
|
|
|
ARG 93 | ||||
| 1lthT01 |
|
|
|
|
|
ARG 93 | ||||
| 1ceqA01 |
|
|
|
|
|
ARG 109 | ||||
| 1cetA01 |
|
|
|
|
|
ARG 109 | ||||
| 1ldgA01 |
|
|
|
|
|
ARG 109 | ||||
| 1t24A01 |
|
|
|
|
|
ARG 109 | ||||
| 1t25A01 |
|
|
|
|
|
ARG 109 | ||||
| 1t26A01 |
|
|
|
|
|
ARG 109 | ||||
| 1t2cA01 |
|
|
|
|
|
ARG 109 | ||||
| 1t2dA01 |
|
|
|
|
|
ARG 94 | ||||
| 1t2eA01 |
|
|
|
|
|
ARG 109 | ||||
| 1u4oA01 |
|
|
|
|
|
ARG 109 | ||||
| 1u4sA01 |
|
|
|
|
|
ARG 109 | ||||
| 1u5aA01 |
|
|
|
|
|
ARG 109 | ||||
| 1u5cA01 |
|
|
|
|
|
ARG 109 | ||||
| 1xivA01 |
|
|
|
|
|
ARG 109 | ||||
| 2a94A01 |
|
|
|
|
|
ARG 109 | ||||
| 1ldmA01 |
|
|
|
|
|
ARG 106 | ||||
| 3ldhA01 |
|
|
|
|
|
ARG 109 | ||||
| 6ldhA01 |
|
|
|
|
|
ARG 106 | ||||
| 8ldhA01 |
|
|
|
|
|
ARG 106 | ||||
| 9ldbA01 |
|
|
|
|
|
ARG 109 | ||||
| 9ldbB01 |
|
|
|
|
|
ARG 109 | ||||
| 9ldtA01 |
|
|
|
|
|
ARG 109 | ||||
| 9ldtB01 |
|
|
|
|
|
ARG 109 | ||||
| 5ldhA01 |
|
|
|
|
|
ARG 109 | ||||
| 2ldxA01 |
|
|
|
|
|
ARG 105 | ||||
| 1i10A01 |
|
|
|
|
|
ARG 105 | ||||
| 1i10B01 |
|
|
|
|
|
ARG 105 | ||||
| 1i10C01 |
|
|
|
|
|
ARG 105 | ||||
| 1i10D01 |
|
|
|
|
|
ARG 105 | ||||
| 1i10E01 |
|
|
|
|
|
ARG 105 | ||||
| 1i10F01 |
|
|
|
|
|
ARG 105 | ||||
| 1i10G01 |
|
|
|
|
|
invisible 101-106 | ||||
| 1i10H01 |
|
|
|
|
|
ARG 105 | ||||
| 1i0zA01 |
|
|
|
|
|
ARG 106 | ||||
| 1i0zB01 |
|
|
|
|
|
ARG 106 | ||||
| 1t2fA01 |
|
|
|
|
|
ARG 106 | ||||
| 1t2fB01 |
|
|
|
|
|
ARG 106 | ||||
| 1t2fC01 |
|
|
|
|
|
ARG 106 | ||||
| 1t2fD01 |
|
|
|
|
|
ARG 106 | ||||
| 1ldbA02 |
|
|
|
|
|
ASP 166;ARG 169;HIS 193 | ||||
| 1ldnA02 |
|
|
|
|
|
ASP 166;ARG 169;HIS 193 | ||||
| 1ldnB02 |
|
|
|
|
|
ASP 166;ARG 169;HIS 193 | ||||
| 1ldnC02 |
|
|
|
|
|
ASP 166;ARG 169;HIS 193 | ||||
| 1ldnD02 |
|
|
|
|
|
ASP 166;ARG 169;HIS 193 | ||||
| 1ldnE02 |
|
|
|
|
|
ASP 166;ARG 169;HIS 193 | ||||
| 1ldnF02 |
|
|
|
|
|
ASP 166;ARG 169;HIS 193 | ||||
| 1ldnG02 |
|
|
|
|
|
ASP 166;ARG 169;HIS 193 | ||||
| 1ldnH02 |
|
|
|
|
|
ASP 166;ARG 169;HIS 193 | ||||
| 2ldbA02 |
|
|
|
|
|
ASP 166;ARG 169;HIS 193 | ||||
| 1llcA02 |
|
|
|
|
|
ASP 168;ARG 171;HIS 195 | ||||
| 1a5zA02 |
|
|
|
|
|
ASP 168;ARG 171;HIS 195 | ||||
| 1lldA02 |
|
|
|
|
|
ASP 153;ARG 156;HIS 180 | mutant C199S | |||
| 1lldB02 |
|
|
|
|
|
ASP 153;ARG 156;HIS 180 | mutant C199S | |||
| 1lthR02 |
|
|
|
|
|
ASP 153;ARG 156;HIS 180 | mutant C199S | |||
| 1lthT02 |
|
|
|
|
|
ASP 153;ARG 156;HIS 180 | mutant C199S | |||
| 1ceqA02 |
|
|
|
|
|
ASP 168;ARG 171;HIS 195 | ||||
| 1cetA02 |
|
|
|
|
|
ASP 168;ARG 171;HIS 195 | ||||
| 1ldgA02 |
|
|
|
|
|
ASP 168;ARG 171;HIS 195 | ||||
| 1t24A02 |
|
|
|
|
|
ASP 168;ARG 171;HIS 195 | ||||
| 1t25A02 |
|
|
|
|
|
ASP 168;ARG 171;HIS 195 | ||||
| 1t26A02 |
|
|
|
|
|
ASP 168;ARG 171;HIS 195 | ||||
| 1t2cA02 |
|
|
|
|
|
ASP 168;ARG 171;HIS 195 | ||||
| 1t2dA02 |
|
|
|
|
|
ASP 154;ARG 157;HIS 181 | ||||
| 1t2eA02 |
|
|
|
|
|
ASP 168;ARG 171;HIS 195 | ||||
| 1u4oA02 |
|
|
|
|
|
ASP 168;ARG 171;HIS 195 | ||||
| 1u4sA02 |
|
|
|
|
|
ASP 168;ARG 171;HIS 195 | ||||
| 1u5aA02 |
|
|
|
|
|
ASP 168;ARG 171;HIS 195 | ||||
| 1u5cA02 |
|
|
|
|
|
ASP 168;ARG 171;HIS 195 | ||||
| 1xivA02 |
|
|
|
|
|
ASP 168;ARG 171;HIS 195 | ||||
| 2a94A02 |
|
|
|
|
|
ASP 168;ARG 171;HIS 195 | ||||
| 1ldmA02 |
|
|
|
|
|
ASP 166;ARG 169;HIS 193 | ||||
| 3ldhA02 |
|
|
|
|
|
ASP 168;ARG 171;HIS 195 | ||||
| 6ldhA02 |
|
|
|
|
|
ASP 166;ARG 169;HIS 193 | ||||
| 8ldhA02 |
|
|
|
|
|
ASP 166;ARG 169;HIS 193 | ||||
| 9ldbA02 |
|
|
|
|
|
ASP 168;ARG 171;HIS 195 | ||||
| 9ldbB02 |
|
|
|
|
|
ASP 168;ARG 171;HIS 195 | ||||
| 9ldtA02 |
|
|
|
|
|
ASP 168;ARG 171;HIS 195 | ||||
| 9ldtB02 |
|
|
|
|
|
ASP 168;ARG 171;HIS 195 | ||||
| 5ldhA02 |
|
|
|
|
|
ASP 168;ARG 171;HIS 195 | ||||
| 2ldxA02 |
|
|
|
|
|
ASP 165;ARG 168;HIS 192 | ||||
| 1i10A02 |
|
|
|
|
|
ASP 165;ARG 168;HIS 192 | ||||
| 1i10B02 |
|
|
|
|
|
ASP 165;ARG 168;HIS 192 | ||||
| 1i10C02 |
|
|
|
|
|
ASP 165;ARG 168;HIS 192 | ||||
| 1i10D02 |
|
|
|
|
|
ASP 165;ARG 168;HIS 192 | ||||
| 1i10E02 |
|
|
|
|
|
ASP 165;ARG 168;HIS 192 | ||||
| 1i10F02 |
|
|
|
|
|
ASP 165;ARG 168;HIS 192 | ||||
| 1i10G02 |
|
|
|
|
|
ASP 165;ARG 168;HIS 192 | ||||
| 1i10H02 |
|
|
|
|
|
ASP 165;ARG 168;HIS 192 | ||||
| 1i0zA02 |
|
|
|
|
|
ASP 166;ARG 169;HIS 193 | ||||
| 1i0zB02 |
|
|
|
|
|
ASP 166;ARG 169;HIS 193 | ||||
| 1t2fA02 |
|
|
|
|
|
ASP 166;ARG 169;HIS 193 | ||||
| 1t2fB02 |
|
|
|
|
|
ASP 166;ARG 169;HIS 193 | ||||
| 1t2fC02 |
|
|
|
|
|
ASP 166;ARG 169;HIS 193 | ||||
| 1t2fD02 |
|
|
|
|
|
ASP 166;ARG 169;HIS 193 | ||||
| References for Catalytic Mechanism | ||
|---|---|---|
| References | Sections | No. of steps in catalysis |
|
[3]
|
Fig.2, p.2677-2679 | |
|
[5]
|
Fig.9, p.303-305 | |
|
[9]
|
p.462-465 | |
|
[12]
|
Fig.1, p.178-179 | |
|
[16]
|
Fig.12, p.1133-1137 | |
|
[22]
|
Fig. 1, p.228 | |
|
[23]
|
p.771 | |
|
[28]
|
p.1355-1358 | |
| References | |
|---|---|
| [1] | |
| Resource | |
| Comments | ATOMIC COORDINATES |
| Medline ID | |
| PubMed ID | 4795361 |
| Journal | Biochem Biophys Res Commun |
| Year | 1973 |
| Volume | 53 |
| Pages | 46-51 |
| Authors | Adams MJ, Ford GC, Liljas A, Rossmann MG |
| Title | Atomic co-ordinates for dogfish M4 apo-lactate dehydrogenase. |
| Related PDB | |
| Related UniProtKB | P00341 |
| [2] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 940154 |
| Journal | J Mol Biol |
| Year | 1976 |
| Volume | 102 |
| Pages | 759-79 |
| Authors | White JL, Hackert ML, Buehner M, Adams MJ, Ford GC, Lentz PJ Jr, Smiley IE, Steindel SJ, Rossmann MG |
| Title | A comparison of the structures of apo dogfish M4 lactate dehydrogenase and its ternary complexes. |
| Related PDB | 3ldh |
| Related UniProtKB | |
| [3] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) |
| Medline ID | |
| PubMed ID | 197516 |
| Journal | Proc Natl Acad Sci U S A |
| Year | 1977 |
| Volume | 74 |
| Pages | 2677-81 |
| Authors | Eventoff W, Rossmann MG, Taylor SS, Torff HJ, Meyer H, Keil W, Kiltz HH |
| Title | Structural adaptations of lactate dehydrogenase isozymes. |
| Related PDB | |
| Related UniProtKB | P00341 |
| [4] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) |
| Medline ID | |
| PubMed ID | 468772 |
| Journal | J Biol Chem |
| Year | 1979 |
| Volume | 254 |
| Pages | 7611-20 |
| Authors | Musick WD, Rossmann MG |
| Title | The structure of mouse testicular lactate dehydrogenase isoenzyme C4 at 2.9 A resolution. |
| Related PDB | |
| Related UniProtKB | P00342 |
| [5] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) |
| Medline ID | |
| PubMed ID | 7338899 |
| Journal | J Mol Biol |
| Year | 1981 |
| Volume | 151 |
| Pages | 289-307 |
| Authors | Grau UM, Trommer WE, Rossmann MG |
| Title | Structure of the active ternary complex of pig heart lactate dehydrogenase with S-lac-NAD at 2.7 A resolution. |
| Related PDB | 5ldh |
| Related UniProtKB | P00336 |
| [6] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 6411465 |
| Journal | Eur J Biochem |
| Year | 1983 |
| Volume | 134 |
| Pages | 503-11 |
| Authors | Hensel R, Mayr U, Yang CY |
| Title | The complete primary structure of the allosteric L-lactate dehydrogenase from Lactobacillus casei. |
| Related PDB | 1llc |
| Related UniProtKB | |
| [7] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS). |
| Medline ID | |
| PubMed ID | |
| Journal | Acta Crystallogr A |
| Year | 1984 |
| Volume | 40 |
| Pages | 32-4 |
| Authors | Buehner M, Hecht HJ |
| Title | Structure determination of the allosteric L-lactate dehydrogenase from Lactobacillus-casei at 3A resolution. |
| Related PDB | |
| Related UniProtKB | P00343 |
| [8] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 2443489 |
| Journal | J Biol Chem |
| Year | 1987 |
| Volume | 262 |
| Pages | 13155-62 |
| Authors | Hogrefe HH, Griffith JP, Rossmann MG, Goldberg E |
| Title | Characterization of the antigenic sites on the refined 3-A resolution structure of mouse testicular lactate dehydrogenase C4. |
| Related PDB | 2ldx |
| Related UniProtKB | |
| [9] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (0.25 ANGSTROMS). |
| Medline ID | |
| PubMed ID | 3430615 |
| Journal | J Mol Biol |
| Year | 1987 |
| Volume | 198 |
| Pages | 445-67 |
| Authors | Abad-Zapatero C, Griffith JP, Sussman JL, Rossmann MG |
| Title | Refined crystal structure of dogfish M4 apo-lactate dehydrogenase. |
| Related PDB | 1ldm 6ldh 8ldh |
| Related UniProtKB | P00341 |
| [10] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 2610514 |
| Journal | Appl Biochem Biotechnol |
| Year | 1989 |
| Volume | 22 |
| Pages | 169-79 |
| Authors | Simon ES, Plante R, Whitesides GM |
| Title |
D-lactate dehydrogenase. |
| Related PDB | |
| Related UniProtKB | |
| [11] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 2330370 |
| Journal | Proteins |
| Year | 1990 |
| Volume | 7 |
| Pages | 74-92 |
| Authors | Piontek K, Chakrabarti P, Schar HP, Rossmann MG, Zuber H |
| Title | Structure determination and refinement of Bacillus stearothermophilus lactate dehydrogenase. |
| Related PDB | 1ldb 2ldb |
| Related UniProtKB | |
| [12] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) |
| Medline ID | |
| PubMed ID | 1678537 |
| Journal | Philos Trans R Soc Lond B Biol Sci |
| Year | 1991 |
| Volume | 332 |
| Pages | 177-84 |
| Authors | Dunn CR, Wilks HM, Halsall DJ, Atkinson T, Clarke AR, Muirhead H, Holbrook JJ |
| Title | Design and synthesis of new enzymes based on the lactate dehydrogenase framework. |
| Related PDB | 9ldb 9ldt |
| Related UniProtKB | P00339 |
| [13] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) |
| Medline ID | |
| PubMed ID | 1731077 |
| Journal | J Mol Biol |
| Year | 1992 |
| Volume | 223 |
| Pages | 317-35 |
| Authors | Wigley DB, Gamblin SJ, Turkenburg JP, Dodson EJ, Piontek K, Muirhead H, Holbrook JJ |
| Title | Structure of a ternary complex of an allosteric lactate dehydrogenase from Bacillus stearothermophilus at 2.5 A resolution. |
| Related PDB | 1ldn |
| Related UniProtKB | P00344 |
| [14] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1304374 |
| Journal | Protein Sci |
| Year | 1992 |
| Volume | 1 |
| Pages | 892-901 |
| Authors | Cortes A, Emery DC, Halsall DJ, Jackson RM, Clarke AR, Holbrook JJ |
| Title | Charge balance in the alpha-hydroxyacid dehydrogenase vacuole: an acid test. |
| Related PDB | |
| Related UniProtKB | |
| [15] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) |
| Medline ID | |
| PubMed ID | 8450537 |
| Journal | J Mol Biol |
| Year | 1993 |
| Volume | 230 |
| Pages | 21-7 |
| Authors | Iwata S, Ohta T |
| Title | Molecular basis of allosteric activation of bacterial L-lactate dehydrogenase. |
| Related PDB | 1lld |
| Related UniProtKB | P19869 |
| [16] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8120891 |
| Journal | J Mol Biol |
| Year | 1994 |
| Volume | 1123-4 |
| Pages | 236(4) |
| Authors | Goldberg JD, Yoshida T, Brick P |
| Title | Crystal structure of a NAD-dependent D-glycerate dehydrogenase at 2.4 A resolution. |
| Related PDB | |
| Related UniProtKB | |
| [17] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) |
| Medline ID | |
| PubMed ID | 7656036 |
| Journal | Nat Struct Biol |
| Year | 1994 |
| Volume | 1 |
| Pages | 176-85 |
| Authors | Iwata S, Kamata K, Yoshida S, Minowa T, Ohta T |
| Title | T and R states in the crystals of bacterial L-lactate dehydrogenase reveal the mechanism for allosteric control. |
| Related PDB | 1lth |
| Related UniProtKB | P19869 |
| [18] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8532681 |
| Journal | Protein Eng |
| Year | 1995 |
| Volume | 8 |
| Pages | 565-73 |
| Authors | Philippopoulos M, Xiang Y, Lim C |
| Title | Identifying the mechanism of protein loop closure: a molecular dynamics simulation of the Bacillus stearothermophilus LDH loop in solution. |
| Related PDB | |
| Related UniProtKB | |
| [19] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (1.74 ANGSTROMS) |
| Medline ID | |
| PubMed ID | 8901865 |
| Journal | Nat Struct Biol |
| Year | 1996 |
| Volume | 3 |
| Pages | 912-5 |
| Authors | Dunn CR, Banfield MJ, Barker JJ, Higham CW, Moreton KM, Turgut-Balik D, Brady RL, Holbrook JJ |
| Title | The structure of lactate dehydrogenase from Plasmodium falciparum reveals a new target for anti-malarial design. |
| Related PDB | 1ceq 1ldg |
| Related UniProtKB | Q27743 |
| [20] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9162946 |
| Journal | Proteins |
| Year | 1996 |
| Volume | 24 |
| Pages | 450-66 |
| Authors | van der Spoel D, Vogel HJ, Berendsen HJ |
| Title | Molecular dynamics simulations of N-terminal peptides from a nucleotide binding protein. |
| Related PDB | |
| Related UniProtKB | |
| [21] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9017191 |
| Journal | Biophys J |
| Year | 1997 |
| Volume | 72 |
| Pages | 619-26 |
| Authors | van Beek J, Callender R, Gunner MR |
| Title | The contribution of electrostatic and van der Waals interactions to the stereospecificity of the reaction catalyzed by lactate dehydrogenase. |
| Related PDB | |
| Related UniProtKB | |
| [22] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9329087 |
| Journal | Proteins |
| Year | 1997 |
| Volume | 29 |
| Pages | 228-39 |
| Authors | Dafforn TR, Badcoe IG, Sessions RB, el Hawrani AS, Holbrook JJ |
| Title | Correlation of the enzyme activities of Bacillus stearothermophilus lactate dehydrogenase on three substrates with the results of molecular dynamics/energy minimization conformational searching. |
| Related PDB | |
| Related UniProtKB | |
| [23] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) |
| Medline ID | |
| PubMed ID | 9655830 |
| Journal | Structure |
| Year | 1998 |
| Volume | 6 |
| Pages | 769-81 |
| Authors | Auerbach G, Ostendorp R, Prade L, Korndorfer I, Dams T, Huber R, Jaenicke R |
| Title | Lactate dehydrogenase from the hyperthermophilic bacterium thermotoga maritima: the crystal structure at 2.1 A resolution reveals strategies for intrinsic protein stabilization. |
| Related PDB | 1a5z |
| Related UniProtKB | P16115 |
| [24] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 10187806 |
| Journal | J Biol Chem |
| Year | 1999 |
| Volume | 274 |
| Pages | 10213-8 |
| Authors | Read JA, Wilkinson KW, Tranter R, Sessions RB, Brady RL |
| Title | Chloroquine binds in the cofactor binding site of Plasmodium falciparum lactate dehydrogenase. |
| Related PDB | 1cet |
| Related UniProtKB | |
| [25] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10556245 |
| Journal | Protein Eng |
| Year | 1999 |
| Volume | 12 |
| Pages | 851-6 |
| Authors | Holmberg N, Ryde U, Bulow L |
| Title | Redesign of the coenzyme specificity in L-lactate dehydrogenase from bacillus stearothermophilus using site-directed mutagenesis and media engineering. |
| Related PDB | |
| Related UniProtKB | |
| [26] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10951199 |
| Journal | Eur J Biochem |
| Year | 2000 |
| Volume | 267 |
| Pages | 5413-20 |
| Authors | Berr K, Wassenberg D, Lilie H, Behlke J, Jaenicke R |
| Title | epsilon-crystallin from duck eye lens comparison of its quaternary structure and stability with other lactate dehydrogenases and complex formation with alpha-crystallin. |
| Related PDB | |
| Related UniProtKB | |
| [27] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11401572 |
| Journal | Biochemistry |
| Year | 2001 |
| Volume | 40 |
| Pages | 7247-52 |
| Authors | Kedzierski P, Moreton K, Clarke AR, Holbrook JJ |
| Title | The A245K mutation exposes another stage of the bacterial L-lactate dehydrogenase reaction mechanism. |
| Related PDB | |
| Related UniProtKB | |
| [28] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11292347 |
| Journal | J Mol Biol |
| Year | 2001 |
| Volume | 307 |
| Pages | 1351-62 |
| Authors | Lee BI, Chang C, Cho SJ, Eom SH, Kim KK, Yu YG, Suh SW |
| Title |
Crystal structure of the MJ0490 gene product of the hyperthermophilic archaebacterium Methanococcus jannaschii, |
| Related PDB | |
| Related UniProtKB | |
| [29] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 11276087 |
| Journal | Proteins |
| Year | 2001 |
| Volume | 43 |
| Pages | 175-85 |
| Authors | Read JA, Winter VJ, Eszes CM, Sessions RB, Brady RL |
| Title | Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase. |
| Related PDB | 1i0z 1i10 |
| Related UniProtKB | |
| [30] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11807949 |
| Journal | Proteins |
| Year | 2002 |
| Volume | 46 |
| Pages | 206-14 |
| Authors | Uchikoba H, Fushinobu S, Wakagi T, Konno M, Taguchi H, Matsuzawa H |
| Title | Crystal structure of non-allosteric L-lactate dehydrogenase from Lactobacillus pentosus at 2.3 A resolution: specific interactions at subunit interfaces. |
| Related PDB | |
| Related UniProtKB | |
| [31] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12967707 |
| Journal | Mol Biochem Parasitol |
| Year | 2003 |
| Volume | 131 |
| Pages | 1-10 |
| Authors | Winter VJ, Cameron A, Tranter R, Sessions RB, Brady RL |
| Title | Crystal structure of Plasmodium berghei lactate dehydrogenase indicates the unique structural differences of these enzymes are shared across the Plasmodium genus. |
| Related PDB | |
| Related UniProtKB | |
| [32] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 15147206 |
| Journal | Biochemistry |
| Year | 2004 |
| Volume | 43 |
| Pages | 6219-29 |
| Authors | Brown WM, Yowell CA, Hoard A, Vander Jagt TA, Hunsaker LA, Deck LM, Royer RE, Piper RC, Dame JB, Makler MT, Vander Jagt DL |
| Title | Comparative structural analysis and kinetic properties of lactate dehydrogenases from the four species of human malarial parasites. |
| Related PDB | |
| Related UniProtKB | |
| [33] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 15117937 |
| Journal | J Biol Chem |
| Year | 2004 |
| Volume | 279 |
| Pages | 31429-39 |
| Authors | Cameron A, Read J, Tranter R, Winter VJ, Sessions RB, Brady RL, Vivas L, Easton A, Kendrick H, Croft SL, Barros D, Lavandera JL, Martin JJ, Risco F, Garcia-Ochoa S, Gamo FJ, Sanz L, Leon L, Ruiz JR, Gabarro R, Mallo A, Gomez de las Heras F |
| Title | Identification and activity of a series of azole-based compounds with lactate dehydrogenase-directed anti-malarial activity. |
| Related PDB | 1t2f 1t24 1t25 1t26 1t2c 1t2d 1t2e |
| Related UniProtKB | |
| [34] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 15978953 |
| Journal | Mol Biochem Parasitol |
| Year | 2005 |
| Volume | 142 |
| Pages | 137-48 |
| Authors | Conners R, Schambach F, Read J, Cameron A, Sessions RB, Vivas L, Easton A, Croft SL, Brady RL |
| Title | Mapping the binding site for gossypol-like inhibitors of Plasmodium falciparum lactate dehydrogenase. |
| Related PDB | 1u4o 1u4s 1u5a 1u5c 1xiv |
| Related UniProtKB | |
| [35] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 16331982 |
| Journal | Biochemistry |
| Year | 2005 |
| Volume | 44 |
| Pages | 16221-8 |
| Authors | Chaikuad A, Fairweather V, Conners R, Joseph-Horne T, Turgut-Balik D, Brady RL |
| Title | Structure of lactate dehydrogenase from Plasmodium vivax: complexes with NADH and APADH. |
| Related PDB | 2a94 |
| Related UniProtKB | |
| Comments |
|---|
|
This enzyme belongs to the LDH famiyl in the LDH/MDH superfamily.
|
| Created | Updated |
|---|---|
| 2004-12-01 | 2012-06-25 |