DB code: T00011
| CATH domain | 1.10.287.140 : Helix Hairpins | |
|---|---|---|
| 3.40.192.10 : Leucine Dehydrogenase; Chain A, domain 1 | Catalytic domain | |
| 3.40.50.720 : Rossmann fold | ||
| E.C. | 1.4.1.3 | |
| CSA | ||
| M-CSA | ||
| MACiE | ||
| CATH domain | Related DB codes (homologues) |
|---|---|
| 3.40.192.10 : Leucine Dehydrogenase; Chain A, domain 1 | D00458 D00032 D00033 D00035 D00605 D00845 D00857 D00858 M00210 T00010 T00414 |
| 3.40.50.720 : Rossmann fold | S00543 S00551 S00552 S00553 S00602 S00604 S00605 S00608 S00610 S00625 S00319 S00328 S00329 S00330 S00331 S00332 D00456 D00457 D00458 S00324 S00320 S00325 S00326 S00327 D00459 S00335 S00336 S00334 T00219 S00339 D00513 D00001 D00002 D00003 D00005 D00007 D00008 D00010 D00012 D00017 D00018 D00023 D00027 D00028 D00031 D00032 D00033 D00034 D00035 D00037 D00048 D00071 D00476 D00481 D00482 D00490 D00492 D00494 D00545 D00601 D00603 D00604 D00605 D00615 D00845 D00857 D00858 M00161 M00171 M00210 T00002 T00010 T00015 T00227 T00247 T00408 T00414 D00827 D00262 D00274 D00275 M00035 T00109 |
| Uniprot Enzyme Name | UniprotKB | Protein name | Synonyms | RefSeq | Pfam |
|---|---|---|---|---|
| P00366 |
Glutamate dehydrogenase 1, mitochondrial
|
GDH
EC 1.4.1.3 |
NP_872593.1
(Protein)
NM_182652.1 (DNA/RNA sequence) |
PF00208
(ELFV_dehydrog)
PF02812 (ELFV_dehydrog_N) [Graphical View] |
| KEGG enzyme name |
|---|
|
glutamate dehydrogenase [NAD(P)+]
glutamic dehydrogenase glutamate dehydrogenase [NAD(P)+] |
| UniprotKB: Accession Number | Entry name | Activity | Subunit | Subcellular location | Cofactor |
|---|---|---|---|---|---|
| P00366 | DHE3_BOVIN | L-glutamate + H(2)O + NAD(P)(+) = 2- oxoglutarate + NH(3) + NAD(P)H. | Homohexamer. | Mitochondrion matrix. |
| KEGG Pathways | Map code | Pathways | E.C. |
|---|---|---|
| MAP00251 | Glutamate metabolism | |
| MAP00330 | Arginine and proline metabolism | |
| MAP00471 | D-Glutamine and D-glutamate metabolism | |
| MAP00910 | Nitrogen metabolism |
| Compound table | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Substrates | Products | Intermediates | |||||||||||||
| KEGG-id | C00025 | C00001 | C00003 | C00006 | C00026 | C00014 | C00080 | C00004 | C00005 | ||||||
| E.C. | |||||||||||||||
| Compound | L-Glutamate | H2O | NAD+ | NADP+ | 2-Oxoglutarate | NH3 | H+ | NADH | NADPH | ||||||
| Type | amino acids,carboxyl group | H2O | amide group,amine group,nucleotide | amide group,amine group,nucleotide | carbohydrate,carboxyl group | amine group,organic ion | others | amide group,amine group,nucleotide | amide group,amine group,nucleotide | ||||||
| ChEBI |
16015 16015 |
15377 15377 |
15846 15846 |
18009 18009 |
30915 30915 |
16134 16134 |
15378 15378 |
16908 16908 |
16474 16474 |
||||||
| PubChem |
33032 44272391 88747398 33032 44272391 88747398 |
22247451 962 22247451 962 |
5893 5893 |
5886 5886 |
51 51 |
222 222 |
1038 1038 |
439153 439153 |
5884 5884 |
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| 1ch6A03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1ch6B03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1ch6C03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1ch6D03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1ch6E03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1ch6F03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwxA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwxB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwxC01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwxD01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwxE01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwxF01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwyA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwyB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwyC01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwyD01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwyE01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwyF01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwzA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwzB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwzC01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwzD01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwzE01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwzF01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1ch6A01 |
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Bound:GLU | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1ch6B01 |
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Bound:GLU | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1ch6C01 |
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Bound:GLU | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1ch6D01 |
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Bound:GLU | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1ch6E01 |
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Bound:GLU | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1ch6F01 |
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Bound:GLU | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwxA02 |
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Bound:GLU | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwxB02 |
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Bound:GLU | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwxC02 |
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Bound:GLU | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwxD02 |
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Bound:GLU | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwxE02 |
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Bound:GLU | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwxF02 |
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Bound:GLU | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwyA02 |
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Unbound | Unbound | Unbound | Bound:AKG | Unbound | Unbound | Unbound | |||
| 1hwyB02 |
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Unbound | Unbound | Unbound | Bound:AKG | Unbound | Unbound | Unbound | |||
| 1hwyC02 |
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Unbound | Unbound | Unbound | Bound:AKG | Unbound | Unbound | Unbound | |||
| 1hwyD02 |
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Unbound | Unbound | Unbound | Bound:AKG | Unbound | Unbound | Unbound | |||
| 1hwyE02 |
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Unbound | Unbound | Unbound | Bound:AKG | Unbound | Unbound | Unbound | |||
| 1hwyF02 |
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Unbound | Unbound | Unbound | Bound:AKG | Unbound | Unbound | Unbound | |||
| 1hwzA02 |
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Bound:GLU | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwzB02 |
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Bound:GLU | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwzC02 |
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Bound:GLU | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwzD02 |
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Bound:GLU | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwzE02 |
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Bound:GLU | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwzF02 |
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Bound:GLU | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1ch6A02 |
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Unbound | Bound:NAD_551 | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1ch6B02 |
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Unbound | Bound:NAD_561 | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1ch6C02 |
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Unbound | Bound:NAD_571 | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1ch6D02 |
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Unbound | Bound:NAD_581 | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1ch6E02 |
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Unbound | Bound:NAD_591 | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1ch6F02 |
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Unbound | Bound:NAD_601 | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwxA03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Bound:NAI_17 | Unbound | |||
| 1hwxB03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Bound:NAI_14 | Unbound | |||
| 1hwxC03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Bound:NAI_20 | Unbound | |||
| 1hwxD03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Bound:NAI_19 | Unbound | |||
| 1hwxE03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Bound:NAI_15 | Unbound | |||
| 1hwxF03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Bound:NAI_21 | Unbound | |||
| 1hwyA03 |
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Unbound | Bound:NAD_38 | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwyB03 |
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Unbound | Bound:NAD_40 | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwyC03 |
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Unbound | Bound:NAD_37 | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwyD03 |
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Unbound | Bound:NAD_41 | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwyE03 |
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Unbound | Bound:NAD_42 | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwyF03 |
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Unbound | Bound:NAD_33 | Unbound | Unbound | Unbound | Unbound | Unbound | |||
| 1hwzA03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Bound:NDP | |||
| 1hwzB03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Bound:NDP | |||
| 1hwzC03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Bound:NDP | |||
| 1hwzD03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Bound:NDP | |||
| 1hwzE03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Bound:NDP | |||
| 1hwzF03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Bound:NDP | |||
| Reference for Active-site residues | ||
|---|---|---|
| resource | references | E.C. |
| Swiss-prot;P00366 | ||
| Active-site residues | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Catalytic residues | Cofactor-binding residues | Modified residues | Main-chain involved in catalysis | Comment | |||||
| 1ch6A03 |
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| 1ch6B03 |
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| 1ch6C03 |
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| 1ch6D03 |
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| 1ch6E03 |
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| 1ch6F03 |
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| 1hwxA01 |
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| 1hwxB01 |
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| 1hwxC01 |
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| 1hwxD01 |
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| 1hwxE01 |
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| 1hwxF01 |
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| 1hwyA01 |
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| 1hwyB01 |
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| 1hwyC01 |
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| 1hwyD01 |
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| 1hwyE01 |
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| 1hwyF01 |
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| 1hwzA01 |
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| 1hwzB01 |
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| 1hwzC01 |
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| 1hwzD01 |
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| 1hwzE01 |
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| 1hwzF01 |
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| 1ch6A01 |
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LYS 126 | ||||
| 1ch6B01 |
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LYS 126 | ||||
| 1ch6C01 |
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LYS 126 | ||||
| 1ch6D01 |
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LYS 126 | ||||
| 1ch6E01 |
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LYS 126 | ||||
| 1ch6F01 |
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LYS 126 | ||||
| 1hwxA02 |
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LYS 126 | ||||
| 1hwxB02 |
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LYS 126 | ||||
| 1hwxC02 |
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LYS 126 | ||||
| 1hwxD02 |
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LYS 126 | ||||
| 1hwxE02 |
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LYS 126 | ||||
| 1hwxF02 |
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LYS 126 | ||||
| 1hwyA02 |
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LYS 126 | ||||
| 1hwyB02 |
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LYS 126 | ||||
| 1hwyC02 |
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LYS 126 | ||||
| 1hwyD02 |
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LYS 126 | ||||
| 1hwyE02 |
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LYS 126 | ||||
| 1hwyF02 |
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LYS 126 | ||||
| 1hwzA02 |
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LYS 126 | ||||
| 1hwzB02 |
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LYS 126 | ||||
| 1hwzC02 |
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LYS 126 | ||||
| 1hwzD02 |
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LYS 126 | ||||
| 1hwzE02 |
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LYS 126 | ||||
| 1hwzF02 |
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LYS 126 | ||||
| 1ch6A02 |
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| 1ch6B02 |
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| 1ch6C02 |
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| 1ch6D02 |
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| 1ch6E02 |
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| 1ch6F02 |
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| 1hwxA03 |
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| 1hwxB03 |
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| 1hwxC03 |
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| 1hwxD03 |
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| 1hwxE03 |
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| 1hwxF03 |
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| 1hwyA03 |
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| 1hwyB03 |
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| 1hwyC03 |
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| 1hwyD03 |
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| 1hwyE03 |
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| 1hwyF03 |
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| 1hwzA03 |
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| 1hwzB03 |
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| 1hwzC03 |
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| 1hwzD03 |
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| 1hwzE03 |
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| 1hwzF03 |
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| References for Catalytic Mechanism | ||
|---|---|---|
| References | Sections | No. of steps in catalysis |
|
[2]
|
Fig.4, p.884 | 3 |
|
[4]
|
p.2749-2751 | |
|
[19]
|
p.714 | |
| References | |
|---|---|
| [1] | |
| Resource | |
| Comments | CHARACTERIZATION. |
| Medline ID | 74252258 |
| PubMed ID | 4365183 |
| Journal | Eur J Biochem |
| Year | 1974 |
| Volume | 43 |
| Pages | 319-25 |
| Authors | Witzemann V, Koberstein R, Sund H, Rasched I, Jornvall H, Noack K |
| Title | Studies of glutamate dehydrogenase: chemical modification and quantitative determination of tryptophan residues. |
| Related PDB | |
| Related UniProtKB | P00366 |
| [2] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7024012 |
| Journal | Int J Biochem |
| Year | 1981 |
| Volume | 13 |
| Pages | 879-86 |
| Authors | Gore MG |
| Title | L-Glutamic acid dehydrogenase. |
| Related PDB | |
| Related UniProtKB | |
| [3] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 6696727 |
| Journal | Biochem J |
| Year | 1984 |
| Volume | 217 |
| Pages | 327-30 |
| Authors | Bell ET, Bell JE |
| Title | Catalytic activity of bovine glutamate dehydrogenase requires a hexamer structure. |
| Related PDB | |
| Related UniProtKB | |
| [4] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 6144102 |
| Journal | Proc Natl Acad Sci U S A |
| Year | 1984 |
| Volume | 81 |
| Pages | 2747-51 |
| Authors | Fisher HF, Viswanathan TS |
| Title | Carbonyl oxygen exchange evidence of imine formation in the glutamate dehydrogenase reaction and identification of the "occult role" of NADPH. |
| Related PDB | |
| Related UniProtKB | |
| [5] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 3442667 |
| Journal | Biochemistry |
| Year | 1987 |
| Volume | 26 |
| Pages | 8443-50 |
| Authors | Banerjee A, Levy HR, Levy GC, LiMuti C, Goldstein BM, Bell JE |
| Title | A transfer nuclear Overhauser effect study of coenzyme binding to distinct sites in binary and ternary complexes in glutamate dehydrogenase. |
| Related PDB | |
| Related UniProtKB | |
| [6] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 3569640 |
| Journal | Int J Biochem |
| Year | 1987 |
| Volume | 19 |
| Pages | 53-61 |
| Authors | Pour-Rahimi F, Nemat-Gorgani M |
| Title | Reversible association of ox liver glutamate dehydrogenase with the inner mitochondrial membrane. |
| Related PDB | |
| Related UniProtKB | |
| [7] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 3149742 |
| Journal | Protein Eng |
| Year | 1988 |
| Volume | 2 |
| Pages | 147-52 |
| Authors | McPherson MJ, Baron AJ, Jones KM, Price GJ, Wootton JC |
| Title | Multiple interactions of lysine-128 of Escherichia coli glutamate dehydrogenase revealed by site-directed mutagenesis studies. |
| Related PDB | |
| Related UniProtKB | |
| [8] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 2575093 |
| Journal | J Biochem (Tokyo) |
| Year | 1989 |
| Volume | 106 |
| Pages | 515-7 |
| Authors | Nakajima N, Nakamura K, Esaki N, Tanaka H, Soda K |
| Title | Enzymatic in situ analysis by 1H-NMR of the hydrogen transfer stereospecificity of NAD(P)+-dependent dehydrogenases. |
| Related PDB | |
| Related UniProtKB | |
| [9] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1743279 |
| Journal | FEBS Lett |
| Year | 1991 |
| Volume | 294 |
| Pages | 1-5 |
| Authors | Fisher HF, Singh N |
| Title | Transduction of enzyme-ligand binding energy into catalytic driving force. |
| Related PDB | |
| Related UniProtKB | |
| [10] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7961946 |
| Journal | J Biol Chem |
| Year | 1994 |
| Volume | 269 |
| Pages | 29592-7 |
| Authors | Saha SK, Maniscalco SJ, Singh N, Fisher HF |
| Title | The demonstration of a glutamate dehydrogenase-NADP-L-glutamate charge-transfer complex and its location on the reaction pathway. |
| Related PDB | |
| Related UniProtKB | |
| [11] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9356294 |
| Journal | J Struct Biol |
| Year | 1997 |
| Volume | 120 |
| Pages | 73-7 |
| Authors | Peterson PE, Pierce J, Smith TJ |
| Title | Crystallization and characterization of bovine liver glutamate dehydrogenase. |
| Related PDB | |
| Related UniProtKB | |
| [12] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9772187 |
| Journal | Biochemistry |
| Year | 1998 |
| Volume | 37 |
| Pages | 14585-90 |
| Authors | Maniscalco SJ, Saha SK, Fisher HF |
| Title | Identification and characterization of kinetically competent carbinolamine and alpha-iminoglutarate complexes in the glutamate dehydrogenase-catalyzed oxidation of L-glutamate using a multiwavelength transient state approach. |
| Related PDB | |
| Related UniProtKB | |
| [13] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10318805 |
| Journal | J Biol Chem |
| Year | 1999 |
| Volume | 274 |
| Pages | 13948-53 |
| Authors | Cho SW, Yoon HY |
| Title | Photoaffinity labeling of brain glutamate dehydrogenase isoproteins with an azido-ADP. |
| Related PDB | |
| Related UniProtKB | |
| [14] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS). |
| Medline ID | 99354411 |
| PubMed ID | 10425679 |
| Journal | Structure Fold Des |
| Year | 1999 |
| Volume | 7 |
| Pages | 769-82 |
| Authors | Peterson PE, Smith TJ |
| Title | The structure of bovine glutamate dehydrogenase provides insights into the mechanism of allostery. |
| Related PDB | 1ch6 1hwx |
| Related UniProtKB | P00366 |
| [15] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11554732 |
| Journal | Biochem Biophys Res Commun |
| Year | 2001 |
| Volume | 287 |
| Pages | 343-7 |
| Authors | Fisher HF, Maniscalco SJ, Tally J |
| Title | Stabilization of noncovalent intermediates in enzymatically catalyzed reactions. |
| Related PDB | |
| Related UniProtKB | |
| [16] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11327816 |
| Journal | Biochemistry |
| Year | 2001 |
| Volume | 40 |
| Pages | 1577-86 |
| Authors | Madhusoodanan KS, Colman RF |
| Title | Adenosine 5'-0-[S-(4-succinimidyl-benzophenone)thiophosphate]: a new photoaffinity label of the allosteric ADP site of bovine liver glutamate dehydrogenase. |
| Related PDB | |
| Related UniProtKB | |
| [17] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11389722 |
| Journal | Eur J Biochem |
| Year | 2001 |
| Volume | 268 |
| Pages | 3205-13 |
| Authors | Cho SW, Yoon HY, Ahn JY, Lee EY, Lee J |
| Title |
Cassette mutagenesis of lysine 130 of human glutamate dehydrogenase. |
| Related PDB | |
| Related UniProtKB | |
| [18] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11686930 |
| Journal | J Biochem (Tokyo) |
| Year | 2001 |
| Volume | 130 |
| Pages | 671-7 |
| Authors | Ghobadi S, Safarian S, Moosavi-Movahedi AA, Ranjbar B |
| Title | Octyl glucoside induced formation of the molten globule-like state of glutamate dehydrogenase. |
| Related PDB | |
| Related UniProtKB | |
| [19] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 11254391 |
| Journal | J Mol Biol |
| Year | 2001 |
| Volume | 307 |
| Pages | 707-20 |
| Authors | Smith TJ, Peterson PE, Schmidt T, Fang J, Stanley CA |
| Title | Structures of bovine glutamate dehydrogenase complexes elucidate the mechanism of purine regulation. |
| Related PDB | 1hwy 1hwz |
| Related UniProtKB | |
| [20] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12324473 |
| Journal | J Biol Chem |
| Year | 2002 |
| Volume | 277 |
| Pages | 46552-8 |
| Authors | Zaganas I, Spanaki C, Karpusas M, Plaitakis A |
| Title | Substitution of Ser for Arg-443 in the regulatory domain of human housekeeping (GLUD1) glutamate dehydrogenase virtually abolishes basal activity and markedly alters the activation of the enzyme by ADP and L-leucine. |
| Related PDB | |
| Related UniProtKB | |
| [21] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11950837 |
| Journal | J Biol Chem |
| Year | 2002 |
| Volume | 277 |
| Pages | 26422-8 |
| Authors | Zaganas I, Plaitakis A |
| Title | Single amino acid substitution (G456A) in the vicinity of the GTP binding domain of human housekeeping glutamate dehydrogenase markedly attenuates GTP inhibition and abolishes the cooperative behavior of the enzyme. |
| Related PDB | |
| Related UniProtKB | |
| [22] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12054821 |
| Journal | J Mol Biol |
| Year | 2002 |
| Volume | 318 |
| Pages | 765-77 |
| Authors | Smith TJ, Schmidt T, Fang J, Wu J, Siuzdak G, Stanley CA |
| Title | The structure of apo human glutamate dehydrogenase details subunit communication and allostery. |
| Related PDB | 1l1f |
| Related UniProtKB | |
| Comments |
|---|
|
This enzyme has got a second coenzyme subsite for NAD(P), |
| Created | Updated |
|---|---|
| 2004-04-01 | 2009-02-26 |