DB code: D00037
| CATH domain | 3.40.50.720 : Rossmann fold | Catalytic domain |
|---|---|---|
| 3.30.9.10 : D-Amino Acid Oxidase; Chain A, domain 2 | Catalytic domain | |
| E.C. | 1.4.3.3 | |
| CSA | ||
| M-CSA | ||
| MACiE | ||
| CATH domain | Related DB codes (homologues) |
|---|---|
| 3.30.9.10 : D-Amino Acid Oxidase; Chain A, domain 2 | D00041 D00064 D00494 T00025 |
| 3.40.50.720 : Rossmann fold | S00543 S00551 S00552 S00553 S00602 S00604 S00605 S00608 S00610 S00625 S00319 S00328 S00329 S00330 S00331 S00332 D00456 D00457 D00458 S00324 S00320 S00325 S00326 S00327 D00459 S00335 S00336 S00334 T00219 S00339 D00513 D00001 D00002 D00003 D00005 D00007 D00008 D00010 D00012 D00017 D00018 D00023 D00027 D00028 D00031 D00032 D00033 D00034 D00035 D00048 D00071 D00476 D00481 D00482 D00490 D00492 D00494 D00545 D00601 D00603 D00604 D00605 D00615 D00845 D00857 D00858 M00161 M00171 M00210 T00002 T00010 T00011 T00015 T00227 T00247 T00408 T00414 D00827 D00262 D00274 D00275 M00035 T00109 |
| Uniprot Enzyme Name | UniprotKB | Protein name | Synonyms | RefSeq | Pfam |
|---|---|---|---|---|
| P00371 |
D-amino-acid oxidase
|
DAMOX
DAAO DAO EC 1.4.3.3 |
NP_999231.1
(Protein)
NM_214066.2 (DNA/RNA sequence) |
PF01266
(DAO)
[Graphical View] |
| KEGG enzyme name |
|---|
|
D-amino-acid oxidase
ophio-amino-acid oxidase L-amino acid:O2 oxidoreductase new yellow enzyme |
| UniprotKB: Accession Number | Entry name | Activity | Subunit | Subcellular location | Cofactor |
|---|---|---|---|---|---|
| P00371 | OXDA_PIG | A D-amino acid + H(2)O + O(2) = a 2-oxo acid + NH(3) + H(2)O(2). | Homodimer. | Peroxisome. | FAD. |
| KEGG Pathways | Map code | Pathways | E.C. |
|---|---|---|
| MAP00260 | Glycine, serine and threonine metabolism | |
| MAP00311 | Penicillin and cephalosporin biosynthesis | |
| MAP00330 | Arginine and proline metabolism | |
| MAP00472 | D-Arginine and D-ornithine metabolism |
| Compound table | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cofactors | Substrates | Products | Intermediates | ||||||||||
| KEGG-id | C00016 | C00405 | C00001 | C00007 | C00161 | C00014 | C00027 | ||||||
| E.C. | |||||||||||||
| Compound | FAD | D-Amino acid | H2O | O2 | 2-Oxo acid | NH3 | H2O2 | Imino acid | |||||
| Type | amide group,amine group,aromatic ring (only carbon atom),aromatic ring (with nitrogen atoms),carbohydrate,nucleotide | amino acids | H2O | others | carbohydrate,carboxyl group | amine group,organic ion | others | ||||||
| ChEBI |
16238 16238 |
15377 15377 |
15379 26689 27140 15379 26689 27140 |
16134 16134 |
16240 16240 |
||||||||
| PubChem |
643975 643975 |
22247451 962 22247451 962 |
977 977 |
222 222 |
22326046 784 22326046 784 |
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| 1aa8A01 |
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Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1aa8B01 |
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Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1an9A01 |
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Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1an9B01 |
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Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1daoA01 |
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Analogue:FAB | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1daoB01 |
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Analogue:FAB | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1daoC01 |
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Analogue:FAB | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1daoD01 |
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Analogue:FAB | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1daoE01 |
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Analogue:FAB | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1daoF01 |
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Analogue:FAB | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1daoG01 |
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Analogue:FAB | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1daoH01 |
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Analogue:FAB | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ddoA01 |
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Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ddoB01 |
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Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ddoC01 |
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Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ddoD01 |
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Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ddoE01 |
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Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ddoF01 |
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Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ddoG01 |
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Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ddoH01 |
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Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1eviA01 |
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Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1eviB01 |
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Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1kifA01 |
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Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1kifB01 |
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Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1kifC01 |
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Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1kifD01 |
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Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1kifE01 |
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Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1kifF01 |
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Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1kifG01 |
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Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1kifH01 |
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Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ve9A01 |
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Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ve9B01 |
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Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1aa8A02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:BEZ | |
| 1aa8B02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:BEZ | |
| 1an9A02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:BE2 | |
| 1an9B02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:BE2 | |
| 1daoA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1daoB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1daoC02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1daoD02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1daoE02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1daoF02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1daoG02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1daoH02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ddoA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-bound:ITR | |
| 1ddoB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-bound:ITR | |
| 1ddoC02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-bound:ITR | |
| 1ddoD02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-bound:ITR | |
| 1ddoE02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-bound:ITR | |
| 1ddoF02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-bound:ITR | |
| 1ddoG02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-bound:ITR | |
| 1ddoH02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-bound:ITR | |
| 1eviA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:2PC | |
| 1eviB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:2PC | |
| 1kifA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:BEZ | |
| 1kifB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:BEZ | |
| 1kifC02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:BEZ | |
| 1kifD02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:BEZ | |
| 1kifE02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:BEZ | |
| 1kifF02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:BEZ | |
| 1kifG02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:BEZ | |
| 1kifH02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:BEZ | |
| 1ve9A02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:BEZ | |
| 1ve9B02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:BEZ | |
| Reference for Active-site residues | ||
|---|---|---|
| resource | references | E.C. |
| Swiss-prot;P00371 & literature [15] | ||
| References for Catalytic Mechanism | ||
|---|---|---|
| References | Sections | No. of steps in catalysis |
|
[9]
|
Scheme 1, Scheme 2, Scheme 3 | |
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[11]
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Fig.7, p.618-619 | |
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[13]
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p.15 | |
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[15]
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Fig.5, p.7498-7499 | |
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[16]
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p.5858-5859 | |
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[18]
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Fig.1, p.804-806 | |
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[19]
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Fig.6, Fig.7, p.829-832 | |
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[22]
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Scheme 2, p.1741-1744 | |
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[23]
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||
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[24]
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Scheme 2 | |
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[26]
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Fig.6, p.12466-12468 | |
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[28]
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Fig.1, p.14120-14121 | |
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[29]
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p.540-541, p.542-544 | |
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[30]
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Scheme 1, Scheme 3, p.29-31 | |
| References | |
|---|---|
| [1] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 20559 |
| Journal | Med J Osaka Univ |
| Year | 1976 |
| Volume | 27 |
| Pages | 33-46 |
| Authors | Horiike K, Shiga K, Nishina Y, Yamano T |
| Title | pH dependence of catalysis of the monomer of hog kidney D-amino acid oxidase. |
| Related PDB | |
| Related UniProtKB | |
| [2] | |
| Resource | |
| Comments | PRELIMINARY STUDIES ON ACTIVE SITE |
| Medline ID | 82120157 |
| PubMed ID | 6120171 |
| Journal | J Biol Chem |
| Year | 1982 |
| Volume | 257 |
| Pages | 1937-44 |
| Authors | Swenson RP, Williams CH Jr, Massey V |
| Title |
Chemical modification of D-amino acid oxidase. |
| Related PDB | |
| Related UniProtKB | P00371 |
| [3] | |
| Resource | |
| Comments | PRELIMINARY STUDIES ON ACTIVE SITE |
| Medline ID | 83082913 |
| PubMed ID | 6129252 |
| Journal | J Biol Chem |
| Year | 1983 |
| Volume | 258 |
| Pages | 497-502 |
| Authors | Swenson RP, Williams CH Jr, Massey V |
| Title | Identification of the histidine residue in D-amino acid oxidase that is covalently modified during inactivation by 5-dimethylaminonaphthalene-1-sulfonyl chloride. |
| Related PDB | |
| Related UniProtKB | P00371 |
| [4] | |
| Resource | |
| Comments | MUTAGENESIS OF Y-55/M-110/H-217 TO SHOW THEY ARE NOT IN ACTIVE SITE |
| Medline ID | 8900569 |
| PubMed ID | 2901989 |
| Journal | FEBS Lett |
| Year | 1988 |
| Volume | 238 |
| Pages | 269-72 |
| Authors | Watanabe F, Fukui K, Momoi K, Miyake Y |
| Title |
Effect of site-specific mutagenesis of tyrosine-55, |
| Related PDB | |
| Related UniProtKB | P00371 |
| [5] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 2907883 |
| Journal | Int J Biochem |
| Year | 1988 |
| Volume | 20 |
| Pages | 1235-8 |
| Authors | Nagata Y, Shimojo T, Akino T |
| Title | Two spectrophotometric assays for D-amino acid oxidase: for the study of distribution patterns. |
| Related PDB | |
| Related UniProtKB | |
| [6] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 2570065 |
| Journal | J Biochem (Tokyo) |
| Year | 1989 |
| Volume | 105 |
| Pages | 1024-9 |
| Authors | Watanabe F, Fukui K, Momoi K, Miyake Y |
| Title |
Site-specific mutagenesis of lysine-204, |
| Related PDB | |
| Related UniProtKB | |
| [7] | |
| Resource | |
| Comments | ACTIVE SITES TYR-228 AND HIS-307 |
| Medline ID | 91201275 |
| PubMed ID | 1673125 |
| Journal | J Biochem (Tokyo) |
| Year | 1991 |
| Volume | 109 |
| Pages | 171-7 |
| Authors | Miyano M, Fukui K, Watanabe F, Takahashi S, Tada M, Kanashiro M, Miyake Y |
| Title |
Studies on Phe-228 and Leu-307 recombinant mutants of porcine kidney D-amino acid oxidase: expression, |
| Related PDB | |
| Related UniProtKB | P00371 |
| [8] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1351830 |
| Journal | Comp Biochem Physiol B |
| Year | 1992 |
| Volume | 101 |
| Pages | 509-11 |
| Authors | Brachet P, Puigserver A |
| Title | Regional differences for the D-amino acid oxidase-catalysed oxidation of D-methionine in chicken small intestine. |
| Related PDB | |
| Related UniProtKB | |
| [9] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7908225 |
| Journal | Biochemistry |
| Year | 1994 |
| Volume | 33 |
| Pages | 4001-7 |
| Authors | Denu JM, Fitzpatrick PF |
| Title |
Intrinsic primary, |
| Related PDB | |
| Related UniProtKB | |
| [10] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7989339 |
| Journal | J Biol Chem |
| Year | 1994 |
| Volume | 269 |
| Pages | 31666-73 |
| Authors | Pollegioni L, Fukui K, Massey V |
| Title | Studies on the kinetic mechanism of pig kidney D-amino acid oxidase by site-directed mutagenesis of tyrosine 224 and tyrosine 228. |
| Related PDB | |
| Related UniProtKB | |
| [11] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8690726 |
| Journal | J Biochem (Tokyo) |
| Year | 1995 |
| Volume | 118 |
| Pages | 614-20 |
| Authors | Nishina Y, Sato K, Miura R, Shiga K |
| Title | Structures of charge-transfer complexes of flavoenzyme D-amino acid oxidase: a study by resonance Raman spectroscopy and extended Huckel molecular orbital method. |
| Related PDB | |
| Related UniProtKB | |
| [12] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8681967 |
| Journal | Eur J Biochem |
| Year | 1996 |
| Volume | 238 |
| Pages | 519-28 |
| Authors | Stocker A, Hecht HJ, Buckmann AF |
| Title |
Synthesis, |
| Related PDB | |
| Related UniProtKB | |
| [13] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY |
| Medline ID | 97018220 |
| PubMed ID | 8864836 |
| Journal | J Biochem (Tokyo) |
| Year | 1996 |
| Volume | 120 |
| Pages | 14-7 |
| Authors | Mizutani H, Miyahara I, Hirotsu K, Nishina Y, Shiga K, Setoyama C, Miura R |
| Title | Three-dimensional structure of porcine kidney D-amino acid oxidase at 3.0 A resolution. |
| Related PDB | 1aa8 1ve9 |
| Related UniProtKB | P00371 |
| [14] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8827446 |
| Journal | J Biochem (Tokyo) |
| Year | 1996 |
| Volume | 119 |
| Pages | 1114-7 |
| Authors | Setoyama C, Miura R, Nishina Y, Shiga K, Mizutani H, Miyahara I, Hirotsu K |
| Title | Crystallization of expressed porcine kidney D-amino acid oxidase and preliminary X-ray crystallographic characterization. |
| Related PDB | |
| Related UniProtKB | |
| [15] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) |
| Medline ID | 96353844 |
| PubMed ID | 8755502 |
| Journal | Proc Natl Acad Sci U S A |
| Year | 1996 |
| Volume | 93 |
| Pages | 7496-501 |
| Authors | Mattevi A, Vanoni MA, Todone F, Rizzi M, Teplyakov A, Coda A, Bolognesi M, Curti B |
| Title | Crystal structure of D-amino acid oxidase: a case of active site mirror-image convergent evolution with flavocytochrome b2. |
| Related PDB | 1kif |
| Related UniProtKB | P00371 |
| [16] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY |
| Medline ID | 97297794 |
| PubMed ID | 9153426 |
| Journal | Biochemistry |
| Year | 1997 |
| Volume | 36 |
| Pages | 5853-60 |
| Authors | Todone F, Vanoni MA, Mozzarelli A, Bolognesi M, Coda A, Curti B, Mattevi A |
| Title | Active site plasticity in D-amino acid oxidase: a crystallographic analysis. |
| Related PDB | 1ddo 1dao |
| Related UniProtKB | P00371 |
| [17] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9153402 |
| Journal | Biochemistry |
| Year | 1997 |
| Volume | 36 |
| Pages | 5624-32 |
| Authors | Vanoni MA, Cosma A, Mazzeo D, Mattevi A, Todone F, Curti B |
| Title | Limited proteolysis and X-ray crystallography reveal the origin of substrate specificity and of the rate-limiting product release during oxidation of D-amino acids catalyzed by mammalian D-amino acid oxidase. |
| Related PDB | |
| Related UniProtKB | |
| [18] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9434899 |
| Journal | Curr Opin Struct Biol |
| Year | 1997 |
| Volume | 7 |
| Pages | 804-10 |
| Authors | Mattevi A, Vanoni MA, Curti B |
| Title | Structure of D-amino acid oxidase: new insights from an old enzyme. |
| Related PDB | |
| Related UniProtKB | |
| [19] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 9399588 |
| Journal | J Biochem (Tokyo) |
| Year | 1997 |
| Volume | 122 |
| Pages | 825-33 |
| Authors | Miura R, Setoyama C, Nishina Y, Shiga K, Mizutani H, Miyahara I, Hirotsu K |
| Title | Structural and mechanistic studies on D-amino acid oxidase x substrate complex: implications of the crystal structure of enzyme x substrate analog complex. |
| Related PDB | 1an9 |
| Related UniProtKB | |
| [20] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9268372 |
| Journal | J Biol Chem |
| Year | 1997 |
| Volume | 272 |
| Pages | 22248-52 |
| Authors | Raibekas AA, Massey V |
| Title | Glycerol-assisted restorative adjustment of flavoenzyme conformation perturbed by site-directed mutagenesis. |
| Related PDB | |
| Related UniProtKB | |
| [21] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10427728 |
| Journal | FEMS Microbiol Lett |
| Year | 1999 |
| Volume | 176 |
| Pages | 443-8 |
| Authors | Lin LL, Wang WC, Ju SS, Chien HR, Hsu WH |
| Title |
The role of a conserved histidine residue, |
| Related PDB | |
| Related UniProtKB | |
| [22] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11130179 |
| Journal | Cell Mol Life Sci |
| Year | 2000 |
| Volume | 57 |
| Pages | 1732-47 |
| Authors | Pilone MS |
| Title | D-Amino acid oxidase: new findings. |
| Related PDB | |
| Related UniProtKB | |
| [23] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 10876160 |
| Journal | J Biochem (Tokyo) |
| Year | 2000 |
| Volume | 128 |
| Pages | 73-81 |
| Authors | Mizutani H, Miyahara I, Hirotsu K, Nishina Y, Shiga K, Setoyama C, Miura R |
| Title |
Three-dimensional structure of the purple intermediate of porcine kidney D-amino acid oxidase. |
| Related PDB | 1evi |
| Related UniProtKB | |
| [24] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10920257 |
| Journal | J Biochem (Tokyo) |
| Year | 2000 |
| Volume | 128 |
| Pages | 213-23 |
| Authors | Nishina Y, Sato K, Miura R, Shiga K |
| Title | Substrate recognition and activation mechanism of D-amino acid oxidase: a study using substrate analogs. |
| Related PDB | |
| Related UniProtKB | |
| [25] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10716694 |
| Journal | Proc Natl Acad Sci U S A |
| Year | 2000 |
| Volume | 97 |
| Pages | 3089-93 |
| Authors | Raibekas AA, Fukui K, Massey V |
| Title | Design and properties of human D-amino acid oxidase with covalently attached flavin. |
| Related PDB | |
| Related UniProtKB | |
| [26] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11070076 |
| Journal | Proc Natl Acad Sci U S A |
| Year | 2000 |
| Volume | 97 |
| Pages | 12463-8 |
| Authors | Umhau S, Pollegioni L, Molla G, Diederichs K, Welte W, Pilone MS, Ghisla S |
| Title | The x-ray structure of D-amino acid oxidase at very high resolution identifies the chemical mechanism of flavin-dependent substrate dehydrogenation. |
| Related PDB | 1c0k 1c0l 1c0p |
| Related UniProtKB | |
| [27] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11686926 |
| Journal | J Biochem (Tokyo) |
| Year | 2001 |
| Volume | 130 |
| Pages | 637-47 |
| Authors | Nishina Y, Sato K, Shi R, Setoyama C, Miura R, Shiga K |
| Title | On the ligands in charge-transfer complexes of porcine kidney flavoenzyme D-amino acid oxidase in three redox states: a resonance Raman study. |
| Related PDB | |
| Related UniProtKB | |
| [28] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12450374 |
| Journal | Biochemistry |
| Year | 2002 |
| Volume | 41 |
| Pages | 14111-21 |
| Authors | Tilocca A, Gamba A, Vanoni MA, Fois E |
| Title | First-principles molecular dynamics investigation of the D-amino acid oxidative half-reaction catalyzed by the flavoenzyme D-amino acid oxidase. |
| Related PDB | |
| Related UniProtKB | |
| [29] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12445787 |
| Journal | J Mol Biol |
| Year | 2002 |
| Volume | 324 |
| Pages | 535-46 |
| Authors | Pollegioni L, Diederichs K, Molla G, Umhau S, Welte W, Ghisla S, Pilone MS |
| Title | Yeast D-amino acid oxidase: structural basis of its catalytic properties. |
| Related PDB | 1c0i |
| Related UniProtKB | |
| [30] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 15450847 |
| Journal | Biochim Biophys Acta |
| Year | 2004 |
| Volume | 1702 |
| Pages | 19-32 |
| Authors | Boselli A, Piubelli L, Molla G, Sacchi S, Pilone MS, Ghisla S, Pollegioni L |
| Title | On the mechanism of Rhodotorula gracilis D-amino acid oxidase: role of the active site serine 335. |
| Related PDB | |
| Related UniProtKB | |
| Comments |
|---|
|
Although the first domain of this enzyme is classified in CATH 3.40.50.720, Although this enzyme is homologous to yeast counterpart (D00494 in EzCatDB), According to the literature [22], (A) Hydride transfer from D-amino acid to FAD, (B) Hydride transfer from FADH2 to O2, (C) Exchange of double-bonded atoms of the imino acid (Schiff-base deformation by water) |
| Created | Updated |
|---|---|
| 2005-01-25 | 2009-02-26 |