DB code: S00334
| CATH domain | 3.40.50.720 : Rossmann fold | Catalytic domain |
|---|---|---|
| E.C. | 1.3.1.9 | |
| CSA | 1mfp 1qsg | |
| M-CSA | 1mfp 1qsg | |
| MACiE | ||
| CATH domain | Related DB codes (homologues) |
|---|---|
| 3.40.50.720 : Rossmann fold | S00543 S00551 S00552 S00553 S00602 S00604 S00605 S00608 S00610 S00625 S00319 S00328 S00329 S00330 S00331 S00332 D00456 D00457 D00458 S00324 S00320 S00325 S00326 S00327 D00459 S00335 S00336 T00219 S00339 D00513 D00001 D00002 D00003 D00005 D00007 D00008 D00010 D00012 D00017 D00018 D00023 D00027 D00028 D00031 D00032 D00033 D00034 D00035 D00037 D00048 D00071 D00476 D00481 D00482 D00490 D00492 D00494 D00545 D00601 D00603 D00604 D00605 D00615 D00845 D00857 D00858 M00161 M00171 M00210 T00002 T00010 T00011 T00015 T00227 T00247 T00408 T00414 D00827 D00262 D00274 D00275 M00035 T00109 |
| Uniprot Enzyme Name | UniprotKB | Protein name | Synonyms | RefSeq |
|---|---|---|---|
| P80030 |
Enoyl-{acyl-carrier-protein} reductase {NADH}, chloroplastic
|
EC
1.3.1.9
NADH-dependent enoyl-ACP reductase |
|
| P0AEK4 |
Enoyl-{acyl-carrier-protein} reductase {NADH}
|
EC
1.3.1.9
NADH-dependent enoyl-ACP reductase |
NP_415804.1
(Protein)
NC_000913.2 (DNA/RNA sequence) YP_489556.1 (Protein) NC_007779.1 (DNA/RNA sequence) |
| P0A5Y7 |
Enoyl-{acyl-carrier-protein} reductase {NADH}
|
EC
1.3.1.9
NADH-dependent enoyl-ACP reductase |
NP_855172.1
(Protein)
NC_002945.3 (DNA/RNA sequence) |
| P0A5Y6 |
Enoyl-{acyl-carrier-protein} reductase {NADH}
|
EC
1.3.1.9
NADH-dependent enoyl-ACP reductase |
NP_216000.1
(Protein)
NC_000962.3 (DNA/RNA sequence) NP_335982.1 (Protein) NC_002755.2 (DNA/RNA sequence) YP_006514868.1 (Protein) NC_018143.1 (DNA/RNA sequence) |
| KEGG enzyme name |
|---|
|
enoyl-[acyl-carrier-protein] reductase (NADH)
enoyl-[acyl carrier protein] reductase enoyl-ACP reductase NADH-enoyl acyl carrier protein reductase NADH-specific enoyl-ACP reductase enoyl-[acyl-carrier-protein] reductase (NADH) acyl-[acyl-carrier-protein]:NAD+ oxidoreductase |
| UniprotKB: Accession Number | Entry name | Activity | Subunit | Subcellular location | Cofactor |
|---|---|---|---|---|---|
| P80030 | FABI_BRANA | Acyl-[acyl-carrier-protein] + NAD(+) = trans- 2,3-dehydroacyl-[acyl-carrier-protein] + NADH. | Homotetramer. | Plastid, chloroplast. | |
| P0AEK4 | FABI_ECOLI | Acyl-[acyl-carrier-protein] + NAD(+) = trans- 2,3-dehydroacyl-[acyl-carrier-protein] + NADH. | Homotetramer. | Cell inner membrane, Peripheral membrane protein. | |
| P0A5Y7 | INHA_MYCBO | Acyl-[acyl-carrier-protein] + NAD(+) = trans- 2,3-dehydroacyl-[acyl-carrier-protein] + NADH. | Homotetramer (By similarity). | ||
| P0A5Y6 | INHA_MYCTU | Acyl-[acyl-carrier-protein] + NAD(+) = trans- 2,3-dehydroacyl-[acyl-carrier-protein] + NADH. | Homotetramer. |
| KEGG Pathways | Map code | Pathways | E.C. |
|---|---|---|
| MAP00061 | Fatty acid biosynthesis |
| Compound table | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Substrates | Products | Intermediates | |||||||||
| KEGG-id | C00173 | C00003 | C00693 | C00004 | C00080 | ||||||
| E.C. | |||||||||||
| Compound | Acyl-[acyl-carrier protein] | NAD+ | trans-2,3-Dehydroacyl-[acyl-carrier protein] | NADH | H+ | ||||||
| Type | carbohydrate,peptide/protein,phosphate group/phosphate ion,sulfide group | amide group,amine group,nucleotide | carbohydrate,peptide/protein,phosphate group/phosphate ion,sulfide group | amide group,amine group,nucleotide | others | ||||||
| ChEBI |
15846 15846 |
16908 16908 |
15378 15378 |
||||||||
| PubChem |
5893 5893 |
439153 439153 |
1038 1038 |
||||||||
| 1bvrA |
|
|
|
|
|
Analogue:THT | Bound:NAD | Unbound | Unbound | ||
| 1bvrB |
|
|
|
|
|
Analogue:THT | Bound:NAD | Unbound | Unbound | ||
| 1bvrC |
|
|
|
|
|
Analogue:THT | Bound:NAD | Unbound | Unbound | ||
| 1bvrD |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1bvrE |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1bvrF |
|
|
|
|
|
Analogue:THT | Bound:NAD | Unbound | Unbound | ||
| 1c14A |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1c14B |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1cwuA |
|
|
|
|
|
Unbound | Analogue:NAD-TDB | Unbound | Unbound | ||
| 1cwuB |
|
|
|
|
|
Unbound | Analogue:NAD-TDB | Unbound | Unbound | ||
| 1d7oA |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1d8aA |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1d8aB |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1dfgA |
|
|
|
|
|
Unbound | Analogue:NAD-NDT | Unbound | Unbound | ||
| 1dfgB |
|
|
|
|
|
Unbound | Analogue:NAD-NDT | Unbound | Unbound | ||
| 1dfhA |
|
|
|
|
|
Unbound | Analogue:NAD-TDB | Unbound | Unbound | ||
| 1dfhB |
|
|
|
|
|
Unbound | Analogue:NAD-TDB | Unbound | Unbound | ||
| 1dfiA |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1dfiB |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1dfiC |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1dfiD |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1enoA |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1enpA |
|
|
|
|
|
Unbound | Unbound | Unbound | Bound:NAD | ||
| 1enyA |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1enzA |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1i2zA |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1i2zB |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1i30A |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1i30B |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1lx6A |
|
|
|
|
|
Analogue:ZAM | Bound:NAD | Unbound | Unbound | ||
| 1lx6B |
|
|
|
|
|
Analogue:ZAM | Bound:NAD | Unbound | Unbound | ||
| 1lxcA |
|
|
|
|
|
Analogue:AYM | Bound:NAD | Unbound | Unbound | ||
| 1lxcB |
|
|
|
|
|
Analogue:AYM | Bound:NAD | Unbound | Unbound | ||
| 1mfpA |
|
|
|
|
|
Analogue:IDN | Bound:NAD | Unbound | Unbound | ||
| 1mfpB |
|
|
|
|
|
Analogue:IDN | Bound:NAD | Unbound | Unbound | ||
| 1p44A |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1p44B |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1p44C |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1p44D |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1p44E |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1p44F |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1p45A |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1p45B |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1qg6A |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1qg6B |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1qg6C |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1qg6D |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1qsgA |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1qsgB |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1qsgC |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1qsgD |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1qsgE |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1qsgF |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1qsgG |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1qsgH |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | ||
| 1zidA |
|
|
|
|
|
Unbound | Analogue:ZID | Unbound | Unbound | ||
| Reference for Active-site residues | ||
|---|---|---|
| resource | references | E.C. |
| literature [6], [9], [11] | ||
| Active-site residues | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Catalytic residues | Cofactor-binding residues | Modified residues | Main-chain involved in catalysis | Comment | |||||
| 1bvrA |
|
|
|
|
|
TYR 158 | ||||
| 1bvrB |
|
|
|
|
|
TYR 158 | ||||
| 1bvrC |
|
|
|
|
|
TYR 158 | ||||
| 1bvrD |
|
|
|
|
|
TYR 158 | ||||
| 1bvrE |
|
|
|
|
|
TYR 158 | ||||
| 1bvrF |
|
|
|
|
|
TYR 158 | ||||
| 1c14A |
|
|
|
|
|
TYR 156 | ||||
| 1c14B |
|
|
|
|
|
TYR 1156 | ||||
| 1cwuA |
|
|
|
|
|
TYR 198 | mutant A138G | |||
| 1cwuB |
|
|
|
|
|
TYR 198 | mutant A138G | |||
| 1d7oA |
|
|
|
|
|
TYR 198 | ||||
| 1d8aA |
|
|
|
|
|
TYR 156 | ||||
| 1d8aB |
|
|
|
|
|
TYR 156 | ||||
| 1dfgA |
|
|
|
|
|
TYR 156 | ||||
| 1dfgB |
|
|
|
|
|
TYR 156 | ||||
| 1dfhA |
|
|
|
|
|
TYR 156 | ||||
| 1dfhB |
|
|
|
|
|
TYR 156 | ||||
| 1dfiA |
|
|
|
|
|
TYR 156 | ||||
| 1dfiB |
|
|
|
|
|
TYR 156 | ||||
| 1dfiC |
|
|
|
|
|
TYR 156 | ||||
| 1dfiD |
|
|
|
|
|
TYR 156 | ||||
| 1enoA |
|
|
|
|
|
TYR 198 | mutant S1A | |||
| 1enpA |
|
|
|
|
|
TYR 198 | mutant S1A | |||
| 1enyA |
|
|
|
|
|
TYR 158 | ||||
| 1enzA |
|
|
|
|
|
TYR 158 | mutant S94A | |||
| 1i2zA |
|
|
|
|
|
TYR 156 | ||||
| 1i2zB |
|
|
|
|
|
TYR 1156 | ||||
| 1i30A |
|
|
|
|
|
TYR 156 | ||||
| 1i30B |
|
|
|
|
|
TYR 1156 | ||||
| 1lx6A |
|
|
|
|
|
TYR 156 | ||||
| 1lx6B |
|
|
|
|
|
TYR 156 | ||||
| 1lxcA |
|
|
|
|
|
TYR 156 | ||||
| 1lxcB |
|
|
|
|
|
TYR 156 | ||||
| 1mfpA |
|
|
|
|
|
TYR 156 | ||||
| 1mfpB |
|
|
|
|
|
TYR 1156 | ||||
| 1p44A |
|
|
|
|
|
TYR 158 | ||||
| 1p44B |
|
|
|
|
|
TYR 158 | ||||
| 1p44C |
|
|
|
|
|
TYR 158 | ||||
| 1p44D |
|
|
|
|
|
TYR 158 | ||||
| 1p44E |
|
|
|
|
|
TYR 158 | ||||
| 1p44F |
|
|
|
|
|
TYR 158 | ||||
| 1p45A |
|
|
|
|
|
TYR 158 | ||||
| 1p45B |
|
|
|
|
|
TYR 158 | ||||
| 1qg6A |
|
|
|
|
|
TYR 156 | ||||
| 1qg6B |
|
|
|
|
|
TYR 156 | ||||
| 1qg6C |
|
|
|
|
|
TYR 156 | ||||
| 1qg6D |
|
|
|
|
|
TYR 156 | ||||
| 1qsgA |
|
|
|
|
|
TYR 156 | ||||
| 1qsgB |
|
|
|
|
|
TYR 156 | ||||
| 1qsgC |
|
|
|
|
|
TYR 156 | ||||
| 1qsgD |
|
|
|
|
|
TYR 156 | ||||
| 1qsgE |
|
|
|
|
|
TYR 156 | ||||
| 1qsgF |
|
|
|
|
|
TYR 156 | ||||
| 1qsgG |
|
|
|
|
|
TYR 156 | ||||
| 1qsgH |
|
|
|
|
|
TYR 156 | ||||
| 1zidA |
|
|
|
|
|
TYR 158 | mutant T2A | |||
| References for Catalytic Mechanism | ||
|---|---|---|
| References | Sections | No. of steps in catalysis |
|
[5]
|
Fig.8, p.932-933 | |
|
[8]
|
Fig.8, p.1539-1541 | |
|
[10]
|
p.13628-13629 | |
|
[11]
|
||
|
[13]
|
p.30817 | |
|
[14]
|
p.15587-15588 | |
|
[16]
|
||
| References | |
|---|---|
| [1] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 3535882 |
| Journal | Biochemistry |
| Year | 1986 |
| Volume | 25 |
| Pages | 5617-24 |
| Authors | Leanz GF, Hammes GG |
| Title | Kinetic and nuclear magnetic resonance study of the interaction of NADP+ and NADPH with chicken liver fatty acid synthase. |
| Related PDB | |
| Related UniProtKB | |
| [2] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8126737 |
| Journal | J Mol Biol |
| Year | 1994 |
| Volume | 237 |
| Pages | 240-2 |
| Authors | Rafferty JB, Simon JW, Stuitje AR, Slabas AR, Fawcett T, Rice DW |
| Title | Crystallization of the NADH-specific enoyl acyl carrier protein reductase from Brassica napus. |
| Related PDB | |
| Related UniProtKB | |
| [3] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7932735 |
| Journal | J Mol Biol |
| Year | 1994 |
| Volume | 243 |
| Pages | 126-7 |
| Authors | Wagner UG, Bergler H, Fuchsbichler S, Turnowsky F, Hogenauer G, Kratky C |
| Title | Crystallization and preliminary X-ray diffraction studies of the enoyl-ACP reductase from Escherichia coli. |
| Related PDB | |
| Related UniProtKB | |
| [4] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 7886450 |
| Journal | Science |
| Year | 1995 |
| Volume | 267 |
| Pages | 1638-41 |
| Authors | Dessen A, Quemard A, Blanchard JS, Jacobs WR Jr, Sacchettini JC |
| Title | Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis. |
| Related PDB | 1eny 1enz |
| Related UniProtKB | |
| [5] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 74-382. |
| Medline ID | 96097399 |
| PubMed ID | 8535786 |
| Journal | Structure |
| Year | 1995 |
| Volume | 3 |
| Pages | 927-38 |
| Authors | Rafferty JB, Simon JW, Baldock C, Artymiuk PJ, Baker PJ, Stuitje AR, Slabas AR, Rice DW |
| Title | Common themes in redox chemistry emerge from the X-ray structure of oilseed rape (Brassica napus) enoyl acyl carrier protein reductase. |
| Related PDB | 1eno 1enp |
| Related UniProtKB | P80030 |
| [6] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS). |
| Medline ID | 97113207 |
| PubMed ID | 8953047 |
| Journal | Science |
| Year | 1996 |
| Volume | 274 |
| Pages | 2107-10 |
| Authors | Baldock C, Rafferty JB, Sedelnikova SE, Baker PJ, Stuitje AR, Slabas AR, Hawkes TR, Rice DW |
| Title | A mechanism of drug action revealed by structural studies of enoyl reductase. |
| Related PDB | 1dfg 1dfh 1dfi |
| Related UniProtKB | P0AEK4 |
| [7] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9204389 |
| Journal | J Enzyme Inhib |
| Year | 1997 |
| Volume | 11 |
| Pages | 209-16 |
| Authors | Mukherjee S, Katiyar SS |
| Title | Evidence for the essential histidine at the NADPH binding site of enoyl-CoA reductase domain of pigeon liver fatty acid synthetase. |
| Related PDB | |
| Related UniProtKB | |
| [8] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9878369 |
| Journal | J Mol Biol |
| Year | 1998 |
| Volume | 284 |
| Pages | 1529-46 |
| Authors | Baldock C, Rafferty JB, Stuitje AR, Slabas AR, Rice DW |
| Title | The X-ray structure of Escherichia coli enoyl reductase with bound NAD+ at 2.1 A resolution. |
| Related PDB | |
| Related UniProtKB | |
| [9] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS). |
| Medline ID | 98079172 |
| PubMed ID | 9417034 |
| Journal | Science |
| Year | 1998 |
| Volume | 279 |
| Pages | 98-102 |
| Authors | Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC |
| Title | Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis. |
| Related PDB | 1zid |
| Related UniProtKB | P46533 |
| [10] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10521269 |
| Journal | Biochemistry |
| Year | 1999 |
| Volume | 38 |
| Pages | 13623-34 |
| Authors | Parikh S, Moynihan DP, Xiao G, Tonge PJ |
| Title |
Roles of tyrosine 158 and lysine 165 in the catalytic mechanism of InhA, |
| Related PDB | |
| Related UniProtKB | |
| [11] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS). |
| Medline ID | 99425142 |
| PubMed ID | 10493822 |
| Journal | Biochemistry |
| Year | 1999 |
| Volume | 38 |
| Pages | 12514-25 |
| Authors | Ward WH, Holdgate GA, Rowsell S, McLean EG, Pauptit RA, Clayton E, Nichols WW, Colls JG, Minshull CA, Jude DA, Mistry A, Timms D, Camble R, Hales NJ, Britton CJ, Taylor IW |
| Title | Kinetic and structural characteristics of the inhibition of enoyl (acyl carrier protein) reductase by triclosan. |
| Related PDB | 1qg6 |
| Related UniProtKB | P0AEK4 |
| [12] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10196195 |
| Journal | J Biol Chem |
| Year | 1999 |
| Volume | 274 |
| Pages | 11110-4 |
| Authors | Heath RJ, Rubin JR, Holland DR, Zhang E, Snow ME, Rock CO |
| Title | Mechanism of triclosan inhibition of bacterial fatty acid synthesis. |
| Related PDB | |
| Related UniProtKB | |
| [13] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 10521472 |
| Journal | J Biol Chem |
| Year | 1999 |
| Volume | 274 |
| Pages | 30811-7 |
| Authors | Roujeinikova A, Sedelnikova S, de Boer GJ, Stuitje AR, Slabas AR, Rafferty JB, Rice DW |
| Title | Inhibitor binding studies on enoyl reductase reveal conformational changes related to substrate recognition. |
| Related PDB | 1cwu |
| Related UniProtKB | |
| [14] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS). |
| Medline ID | 99269096 |
| PubMed ID | 10336454 |
| Journal | J Biol Chem |
| Year | 1999 |
| Volume | 274 |
| Pages | 15582-9 |
| Authors | Rozwarski DA, Vilcheze C, Sugantino M, Bittman R, Sacchettini JC |
| Title |
Crystal structure of the Mycobacterium tuberculosis enoyl-ACP reductase, |
| Related PDB | 1bvr |
| Related UniProtKB | P46533 |
| [15] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 84-380. |
| Medline ID | 20079515 |
| PubMed ID | 10610777 |
| Journal | J Mol Biol |
| Year | 1999 |
| Volume | 294 |
| Pages | 527-35 |
| Authors | Roujeinikova A, Levy CW, Rowsell S, Sedelnikova S, Baker PJ, Minshull CA, Mistry A, Colls JG, Camble R, Stuitje AR, Slabas AR, Rafferty JB, Pauptit RA, Viner R, Rice DW |
| Title | Crystallographic analysis of triclosan bound to enoyl reductase. |
| Related PDB | 1d7o |
| Related UniProtKB | P80030 |
| [16] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS). |
| Medline ID | 99329134 |
| PubMed ID | 10398587 |
| Journal | J Mol Biol |
| Year | 1999 |
| Volume | 290 |
| Pages | 859-65 |
| Authors | Stewart MJ, Parikh S, Xiao G, Tonge PJ, Kisker C |
| Title | Structural basis and mechanism of enoyl reductase inhibition by triclosan. |
| Related PDB | 1qsg |
| Related UniProtKB | P0AEK4 |
| [17] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10027962 |
| Journal | Mol Microbiol |
| Year | 1999 |
| Volume | 31 |
| Pages | 443-50 |
| Authors | de Boer GJ, Pielage GJ, Nijkamp HJ, Slabas AR, Rafferty JB, Baldock C, Rice DW, Stuitje AR |
| Title | Molecular genetic analysis of enoyl-acyl carrier protein reductase inhibition by diazaborine. |
| Related PDB | |
| Related UniProtKB | |
| [18] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS). |
| Medline ID | 99215552 |
| PubMed ID | 10201369 |
| Journal | Nature |
| Year | 1999 |
| Volume | 398 |
| Pages | 383-4 |
| Authors | Levy CW, Roujeinikova A, Sedelnikova S, Baker PJ, Stuitje AR, Slabas AR, Rice DW, Rafferty JB |
| Title | Molecular basis of triclosan activity. |
| Related PDB | 1d8a |
| Related UniProtKB | P0AEK4 |
| [19] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 10595560 |
| Journal | Protein Sci |
| Year | 1999 |
| Volume | 8 |
| Pages | 2529-32 |
| Authors | Qiu X, Janson CA, Court RI, Smyth MG, Payne DJ, Abdel-Meguid SS |
| Title | Molecular basis for triclosan activity involves a flipping loop in the active site. |
| Related PDB | 1c14 |
| Related UniProtKB | |
| [20] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11068033 |
| Journal | FEBS Lett |
| Year | 2000 |
| Volume | 484 |
| Pages | 65-8 |
| Authors | Fawcett T, Copse CL, Simon JW, Slabas AR |
| Title | Kinetic mechanism of NADH-enoyl-ACP reductase from Brassica napus. |
| Related PDB | |
| Related UniProtKB | |
| [21] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 11514139 |
| Journal | Bioorg Med Chem Lett |
| Year | 2001 |
| Volume | 11 |
| Pages | 2061-5 |
| Authors | Heerding DA, Chan G, DeWolf WE, Fosberry AP, Janson CA, Jaworski DD, McManus E, Miller WH, Moore TD, Payne DJ, Qiu X, Rittenhouse SF, Slater-Radosti C, Smith W, Takata DT, Vaidya KS, Yuan CC, Huffman WF |
| Title | 1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI). |
| Related PDB | 1i2z 1i30 |
| Related UniProtKB | |
| [22] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11491286 |
| Journal | J Mol Biol |
| Year | 2001 |
| Volume | 309 |
| Pages | 171-80 |
| Authors | Levy CW, Baldock C, Wallace AJ, Sedelnikova S, Viner RC, Clough JM, Stuitje AR, Slabas AR, Rice DW, Rafferty JB |
| Title | A study of the structure-activity relationship for diazaborine inhibition of Escherichia coli enoyl-ACP reductase. |
| Related PDB | |
| Related UniProtKB | |
| [23] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11552685 |
| Journal | J Mol Graph Model |
| Year | 2001 |
| Volume | 19 |
| Pages | 560-70 |
| Authors | Chen YZ, Gu XL, Cao ZW |
| Title | Can an optimization/scoring procedure in ligand-protein docking be employed to probe drug-resistant mutations in proteins? |
| Related PDB | |
| Related UniProtKB | |
| [24] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12459184 |
| Journal | Biochem Biophys Res Commun |
| Year | 2002 |
| Volume | 299 |
| Pages | 621-7 |
| Authors | Lee IH, Kim EJ, Cho YH, Lee JK |
| Title | Characterization of a novel enoyl-acyl carrier protein reductase of diazaborine-resistant Rhodobacter sphaeroides mutant. |
| Related PDB | |
| Related UniProtKB | |
| [25] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11792710 |
| Journal | J Biol Chem |
| Year | 2002 |
| Volume | 277 |
| Pages | 13106-14 |
| Authors | Perozzo R, Kuo M, Sidhu AS, Valiyaveettil JT, Bittman R, Jacobs WR Jr, Fidock DA, Sacchettini JC |
| Title | Structural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductase. |
| Related PDB | |
| Related UniProtKB | |
| [26] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12109908 |
| Journal | J Med Chem |
| Year | 2002 |
| Volume | 45 |
| Pages | 3246-56 |
| Authors | Miller WH, Seefeld MA, Newlander KA, Uzinskas IN, Burgess WJ, Heerding DA, Yuan CC, Head MS, Payne DJ, Rittenhouse SF, Moore TD, Pearson SC, Berry V, DeWolf WE Jr, Keller PM, Polizzi BJ, Qiu X, Janson CA, Huffman WF |
| Title | Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI). |
| Related PDB | |
| Related UniProtKB | |
| [27] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 12606558 |
| Journal | J Biol Chem |
| Year | 2003 |
| Volume | 278 |
| Pages | 20851-9 |
| Authors | Kuo MR, Morbidoni HR, Alland D, Sneddon SF, Gourlie BB, Staveski MM, Leonard M, Gregory JS, Janjigian AD, Yee C, Musser JM, Kreiswirth B, Iwamoto H, Perozzo R, Jacobs WR Jr, Sacchettini JC, Fidock DA |
| Title | Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data. |
| Related PDB | 1p44 1p45 |
| Related UniProtKB | |
| [28] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12529157 |
| Journal | J Biomol Struct Dyn |
| Year | 2003 |
| Volume | 20 |
| Pages | 589-94 |
| Authors | Muralidharan J, Suguna K, Surolia A, Surolia N |
| Title | Exploring the interaction energies for the binding of hydroxydiphenyl ethers to enoyl-acyl carrier protein reductases. |
| Related PDB | |
| Related UniProtKB | |
| [29] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 12699381 |
| Journal | J Med Chem |
| Year | 2003 |
| Volume | 46 |
| Pages | 1627-35 |
| Authors | Seefeld MA, Miller WH, Newlander KA, Burgess WJ, DeWolf WE Jr, Elkins PA, Head MS, Jakas DR, Janson CA, Keller PM, Manley PJ, Moore TD, Payne DJ, Pearson S, Polizzi BJ, Qiu X, Rittenhouse SF, Uzinskas IN, Wallis NG, Huffman WF |
| Title | Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK. |
| Related PDB | 1mfp |
| Related UniProtKB | |
| [30] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 15491144 |
| Journal | Biochemistry |
| Year | 2004 |
| Volume | 43 |
| Pages | 13380-9 |
| Authors | Protasevich II, Brouillette CG, Snow ME, Dunham S, Rubin JR, Gogliotti R, Siegel K |
| Title | Role of inhibitor aliphatic chain in the thermodynamics of inhibitor binding to Escherichia coli enoyl-ACP reductase and the Phe203Leu mutant: a proposed mechanism for drug resistance. |
| Related PDB | |
| Related UniProtKB | |
| [31] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 15381426 |
| Journal | J Mol Biol |
| Year | 2004 |
| Volume | 343 |
| Pages | 147-55 |
| Authors | Pidugu LS, Kapoor M, Surolia N, Surolia A, Suguna K |
| Title | Structural basis for the variation in triclosan affinity to enoyl reductases. |
| Related PDB | |
| Related UniProtKB | |
| Comments |
|---|
| Created | Updated |
|---|---|
| 2005-04-11 | 2012-06-01 |