DB code: D00490
| CATH domain | 3.90.180.10 : Quinone Oxidoreductase; Chain A, domain 1 | Catalytic domain |
|---|---|---|
| 3.40.50.720 : Rossmann fold | Catalytic domain | |
| E.C. | 1.1.1.1 | |
| CSA | ||
| M-CSA | ||
| MACiE | ||
| CATH domain | Related DB codes (homologues) |
|---|---|
| 3.40.50.720 : Rossmann fold | S00543 S00551 S00552 S00553 S00602 S00604 S00605 S00608 S00610 S00625 S00319 S00328 S00329 S00330 S00331 S00332 D00456 D00457 D00458 S00324 S00320 S00325 S00326 S00327 D00459 S00335 S00336 S00334 T00219 S00339 D00513 D00001 D00002 D00003 D00005 D00007 D00008 D00010 D00012 D00017 D00018 D00023 D00027 D00028 D00031 D00032 D00033 D00034 D00035 D00037 D00048 D00071 D00476 D00481 D00482 D00492 D00494 D00545 D00601 D00603 D00604 D00605 D00615 D00845 D00857 D00858 M00161 M00171 M00210 T00002 T00010 T00011 T00015 T00227 T00247 T00408 T00414 D00827 D00262 D00274 D00275 M00035 T00109 |
| 3.90.180.10 : Quinone Oxidoreductase; Chain A, domain 1 | D00001 D00002 D00018 D00048 D00481 D00482 D00492 D00615 |
| Uniprot Enzyme Name | UniprotKB | Protein name | Synonyms | Pfam |
|---|---|---|---|
| P26325 |
Alcohol dehydrogenase 1
|
EC
1.1.1.1
|
PF08240
(ADH_N)
PF00107 (ADH_zinc_N) [Graphical View] |
| KEGG enzyme name |
|---|
|
alcohol dehydrogenase
aldehyde reductase ADH alcohol dehydrogenase (NAD) aliphatic alcohol dehydrogenase ethanol dehydrogenase NAD-dependent alcohol dehydrogenase NAD-specific aromatic alcohol dehydrogenase NADH-alcohol dehydrogenase NADH-aldehyde dehydrogenase primary alcohol dehydrogenase yeast alcohol dehydrogenase |
| UniprotKB: Accession Number | Entry name | Activity | Subunit | Subcellular location | Cofactor |
|---|---|---|---|---|---|
| P26325 | ADH1_GADCA | An alcohol + NAD(+) = an aldehyde or ketone + NADH. | Homodimer. | Cytoplasm. | Binds 2 zinc ions per subunit. |
| KEGG Pathways | Map code | Pathways | E.C. |
|---|---|---|
| MAP00010 | Glycolysis / Gluconeogenesis | |
| MAP00071 | Fatty acid metabolism | |
| MAP00120 | Bile acid biosynthesis | |
| MAP00260 | Glycine, serine and threonine metabolism | |
| MAP00350 | Tyrosine metabolism | |
| MAP00624 | 1- and 2-Methylnaphthalene degradation | |
| MAP00641 | 3-Chloroacrylic acid degradation | |
| MAP00830 | Retinol metabolism | |
| MAP00980 | Metabolism of xenobiotics by cytochrome P450 | |
| MAP00982 | Drug metabolism - cytochrome P450 |
| Compound table | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cofactors | Substrates | Products | Intermediates | |||||||||||
| KEGG-id | C00038 | C00003 | C00226 | C00069 | C00004 | C00071 | C00709 | C00080 | ||||||
| E.C. | ||||||||||||||
| Compound | Zinc | NAD+ | Primary alcohol | Alcohol | NADH | Aldehyde | Ketone | H+ | ||||||
| Type | heavy metal | amide group,amine group,nucleotide | carbohydrate | carbohydrate | amide group,amine group,nucleotide | carbohydrate | carbohydrate | others | ||||||
| ChEBI |
29105 29105 |
15846 15846 |
16908 16908 |
15378 15378 |
||||||||||
| PubChem |
32051 32051 |
5893 5893 |
439153 439153 |
1038 1038 |
||||||||||
| 1cdoA01 |
|
|
|
|
|
Bound:2x_ZN | Bound:NAD | Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1cdoB01 |
|
|
|
|
|
Bound:2x_ZN | Bound:NAD | Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1cdoA02 |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1cdoB02 |
|
|
|
|
|
Unbound | Bound:NAD | Unbound | Unbound | Unbound | Unbound | Unbound | ||
| Reference for Active-site residues | ||
|---|---|---|
| resource | references | E.C. |
| Swiss-prot;P40394, P00325, P00327, P00326, P00328,P26325 | ||
| Active-site residues | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Catalytic residues | Cofactor-binding residues | Modified residues | Main-chain involved in catalysis | Comment | |||||
| 1cdoA01 |
|
|
|
|
|
HIS 47;THR 48 | CYS 46;HIS 68;CYS 175(Catalytic zinc binding) | |||
| 1cdoB01 |
|
|
|
|
|
HIS 47;THR 48 | CYS 46;HIS 68;CYS 175(Catalytic zinc binding) | |||
| 1cdoA02 |
|
|
|
|
|
|||||
| 1cdoB02 |
|
|
|
|
|
|||||
| References for Catalytic Mechanism | ||
|---|---|---|
| References | Sections | No. of steps in catalysis |
|
[3]
|
p.582-586 | |
|
[6]
|
p.437-438 | |
|
[9]
|
Fig.4, p.1065-1067 | |
|
[12]
|
Fig.2, p.619-621, p.624-625 | |
|
[31]
|
p.5235-5237 | |
|
[33]
|
p.273 | |
|
[34]
|
p.425-428 | |
|
[43]
|
Fig.2, p.9786-9789, p.9790-9791 | |
|
[44]
|
p.135-136 | |
|
[49]
|
p.666-667 | |
|
[61]
|
Scheme 1, p.13957-13959 | |
|
[66]
|
Chart 1, Chart 2, p.11955-11956, p.11957-11959 | |
|
[67]
|
Fig.5, p.9320 | |
|
[70]
|
Scheme 2, p.480 | |
|
[73]
|
Fig.3 | |
|
[78]
|
Scheme 1, p.3023-3025 | |
| References | |
|---|---|
| [1] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS). |
| Medline ID | 76193761 |
| PubMed ID | 178875 |
| Journal | J Mol Biol |
| Year | 1976 |
| Volume | 102 |
| Pages | 27-59 |
| Authors | Eklund H, Nordstrom B, Zeppezauer E, Soderlund G, Ohlsson I, Boiwe T, Soderberg BO, Tapia O, Branden CI, Akeson A |
| Title | Three-dimensional structure of horse liver alcohol dehydrogenase at 2-4 A resolution. |
| Related PDB | |
| Related UniProtKB | P00327 P00328 |
| [2] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 202459 |
| Journal | Eur J Biochem |
| Year | 1977 |
| Volume | 81 |
| Pages | 403-9 |
| Authors | Samama JP, Zeppezauer E, Biellmann JF, Branden CI |
| Title | The crystal structure of complexes between horse liver alcohol dehydrogenase and the coenzyme analogues 3-iodopyridine-adenine dinucleotide and pyridine-adenine dinucleotide. |
| Related PDB | |
| Related UniProtKB | |
| [3] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 7024556 |
| Journal | J Mol Biol |
| Year | 1981 |
| Volume | 146 |
| Pages | 561-87 |
| Authors | Eklund H, Samma JP, Wallen L, Branden CI, Akeson A, Jones TA |
| Title | Structure of a triclinic ternary complex of horse liver alcohol dehydrogenase at 2.9 A resolution. |
| Related PDB | 6adh |
| Related UniProtKB | |
| [4] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY. |
| Medline ID | 85122661 |
| PubMed ID | 6098306 |
| Journal | Biochemistry |
| Year | 1984 |
| Volume | 23 |
| Pages | 5982-96 |
| Authors | Eklund H, Samama JP, Jones TA |
| Title | Crystallographic investigations of nicotinamide adenine dinucleotide binding to horse liver alcohol dehydrogenase. |
| Related PDB | |
| Related UniProtKB | P00327 P00328 |
| [5] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 3771574 |
| Journal | J Biol Chem |
| Year | 1986 |
| Volume | 261 |
| Pages | 15273-80 |
| Authors | Colonna-Cesari F, Perahia D, Karplus M, Eklund H, Braden CI, Tapia O |
| Title |
Interdomain motion in liver alcohol dehydrogenase. |
| Related PDB | 5adh 7adh 8adh |
| Related UniProtKB | |
| [6] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 3608931 |
| Journal | Eur Biophys J |
| Year | 1987 |
| Volume | 14 |
| Pages | 431-9 |
| Authors | Bertini I, Lanini G, Luchinat C, Haas C, Maret W, Zeppezauer M |
| Title | The influence of anions and inhibitors on the catalytic metal ion in Co(II)-substituted horse liver alcohol dehydrogenase. |
| Related PDB | |
| Related UniProtKB | |
| [7] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 2322541 |
| Journal | Biochemistry |
| Year | 1990 |
| Volume | 29 |
| Pages | 196-203 |
| Authors | Strambini GB, Gonnelli M |
| Title |
Tryptophan luminescence from liver alcohol dehydrogenase in its complexes with coenzyme. |
| Related PDB | |
| Related UniProtKB | |
| [8] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1772423 |
| Journal | Biochem Int |
| Year | 1991 |
| Volume | 24 |
| Pages | 451-60 |
| Authors | Fong WP, Keung WM |
| Title | Examination of subunit interaction in human ADH: carboxymethylation of the heterodimer beta 2 gamma 1. |
| Related PDB | |
| Related UniProtKB | |
| [9] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1989677 |
| Journal | Biochemistry |
| Year | 1991 |
| Volume | 30 |
| Pages | 1062-8 |
| Authors | Ehrig T, Hurley TD, Edenberg HJ, Bosron WF |
| Title | General base catalysis in a glutamine for histidine mutant at position 51 of human liver alcohol dehydrogenase. |
| Related PDB | |
| Related UniProtKB | |
| [10] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 2054345 |
| Journal | Biochemistry |
| Year | 1991 |
| Volume | 30 |
| Pages | 6397-401 |
| Authors | Fan F, Lorenzen JA, Plapp BV |
| Title | An aspartate residue in yeast alcohol dehydrogenase I determines the specificity for coenzyme. |
| Related PDB | |
| Related UniProtKB | |
| [11] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1807973 |
| Journal | Eur Biophys J |
| Year | 1991 |
| Volume | 20 |
| Pages | 215-21 |
| Authors | Bauer R, Adolph HW, Andersson I, Danielsen E, Formicka G, Zeppezauer M |
| Title | Coordination geometry for cadmium in the catalytic zinc site of horse liver alcohol dehydrogenase: studies by PAC spectroscopy. |
| Related PDB | |
| Related UniProtKB | |
| [12] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1935957 |
| Journal | Eur J Biochem |
| Year | 1991 |
| Volume | 201 |
| Pages | 615-25 |
| Authors | Adolph HW, Maurer P, Schneider-Bernlohr H, Sartorius C, Zeppezauer M |
| Title |
Substrate specificity and stereoselectivity of horse liver alcohol dehydrogenase. |
| Related PDB | |
| Related UniProtKB | |
| [13] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1712777 |
| Journal | J Biol Chem |
| Year | 1991 |
| Volume | 266 |
| Pages | 13296-302 |
| Authors | Park DH, Plapp BV |
| Title |
Isoenzymes of horse liver alcohol dehydrogenase active on ethanol and steroids. |
| Related PDB | |
| Related UniProtKB | |
| [14] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS). |
| Medline ID | 91376103 |
| PubMed ID | 1896463 |
| Journal | Proc Natl Acad Sci U S A |
| Year | 1991 |
| Volume | 88 |
| Pages | 8149-53 |
| Authors | Hurley TD, Bosron WF, Hamilton JA, Amzel LM |
| Title | Structure of human beta 1 beta 1 alcohol dehydrogenase: catalytic effects of non-active-site substitutions. |
| Related PDB | 3hud |
| Related UniProtKB | P00325 |
| [15] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1368113 |
| Journal | Enzyme Microb Technol |
| Year | 1992 |
| Volume | 14 |
| Pages | 371-5 |
| Authors | Kawakami K, Abe T, Yoshida T |
| Title | Silicone-immobilized biocatalysts effective for bioconversions in nonaqueous media. |
| Related PDB | |
| Related UniProtKB | |
| [16] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1572355 |
| Journal | Eur J Biochem |
| Year | 1992 |
| Volume | 205 |
| Pages | 519-26 |
| Authors | Hoog JO, Eklund H, Jornvall H |
| Title | A single-residue exchange gives human recombinant beta beta alcohol dehydrogenase gamma gamma isozyme properties. |
| Related PDB | |
| Related UniProtKB | |
| [17] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1324852 |
| Journal | FEBS Lett |
| Year | 1992 |
| Volume | 309 |
| Pages | 92-6 |
| Authors | Formicka G, Zeppezauer M, Fey F, Huttermann J |
| Title | Copper(II)-substituted horse liver alcohol dehydrogenase: structure of the minor species. |
| Related PDB | |
| Related UniProtKB | |
| [18] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1544927 |
| Journal | J Biol Chem |
| Year | 1992 |
| Volume | 267 |
| Pages | 5527-33 |
| Authors | Park DH, Plapp BV |
| Title |
Interconversion of E and S isoenzymes of horse liver alcohol dehydrogenase. |
| Related PDB | |
| Related UniProtKB | |
| [19] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8493927 |
| Journal | Adv Exp Med Biol |
| Year | 1993 |
| Volume | 328 |
| Pages | 481-91 |
| Authors | Henehan GT, Kenyon GL, Oppenheimer NJ |
| Title | The oxidation of aldehydes by horse liver alcohol dehydrogenase. |
| Related PDB | |
| Related UniProtKB | |
| [20] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8493923 |
| Journal | Adv Exp Med Biol |
| Year | 1993 |
| Volume | 328 |
| Pages | 451-5 |
| Authors | Hubatsch I, Zeppezauer M, Waidelich D, Bayer E |
| Title | Horse liver alcohol dehydrogenase-S-isozyme: confirmation of the primary structure by protein sequencing and ion spray mass spectrometry. |
| Related PDB | |
| Related UniProtKB | |
| [21] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8493917 |
| Journal | Adv Exp Med Biol |
| Year | 1993 |
| Volume | 328 |
| Pages | 391-400 |
| Authors | Plapp BV, Green DW, Sun HW, Park DH, Kim K |
| Title | Substrate specificity of alcohol dehydrogenases. |
| Related PDB | |
| Related UniProtKB | |
| [22] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8504071 |
| Journal | Biochemistry |
| Year | 1993 |
| Volume | 32 |
| Pages | 5503-7 |
| Authors | Bahnson BJ, Park DH, Kim K, Plapp BV, Klinman JP |
| Title | Unmasking of hydrogen tunneling in the horse liver alcohol dehydrogenase reaction by site-directed mutagenesis. |
| Related PDB | |
| Related UniProtKB | |
| [23] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8422379 |
| Journal | Biochemistry |
| Year | 1993 |
| Volume | 32 |
| Pages | 735-8 |
| Authors | Henehan GT, Oppenheimer NJ |
| Title | Horse liver alcohol dehydrogenase-catalyzed oxidation of aldehydes: dismutation precedes net production of reduced nicotinamide adenine dinucleotide. |
| Related PDB | |
| Related UniProtKB | |
| [24] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8218182 |
| Journal | Biochemistry |
| Year | 1993 |
| Volume | 32 |
| Pages | 11186-94 |
| Authors | Shearer GL, Kim K, Lee KM, Wang CK, Plapp BV |
| Title | Alternative pathways and reactions of benzyl alcohol and benzaldehyde with horse liver alcohol dehydrogenase. |
| Related PDB | |
| Related UniProtKB | |
| [25] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8490046 |
| Journal | Biochim Biophys Acta |
| Year | 1993 |
| Volume | 1163 |
| Pages | 144-8 |
| Authors | Adlercreutz P |
| Title | Activation of enzymes in organic media at low water activity by polyols and saccharides. |
| Related PDB | |
| Related UniProtKB | |
| [26] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7684231 |
| Journal | Enzyme Microb Technol |
| Year | 1993 |
| Volume | 15 |
| Pages | 383-92 |
| Authors | Creagh AL, Prausnitz JM, Blanch HW |
| Title | Structural and catalytic properties of enzymes in reverse micelles. |
| Related PDB | |
| Related UniProtKB | |
| [27] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8354263 |
| Journal | Eur J Biochem |
| Year | 1993 |
| Volume | 215 |
| Pages | 567-72 |
| Authors | Shilton BH, Campbell RL, Walton DJ |
| Title | Site specificity of glycation of horse liver alcohol dehydrogenase in vitro. |
| Related PDB | |
| Related UniProtKB | |
| [28] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) |
| Medline ID | |
| PubMed ID | |
| Journal | Acta Crystallogr D Biol Crystallogr |
| Year | 1994 |
| Volume | 50 |
| Pages | 793-807 |
| Authors | Al-Karadaghi S, Cedergren-Zeppezauer ES, Hovmoeller S, Petratos K, Terry H, Wilson KS |
| Title | Refined crystal structure of liver alcohol dehydrogenase-NADH complex at 1.8-A resolution. |
| Related PDB | |
| Related UniProtKB | P00327 |
| [29] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 8286346 |
| Journal | Biochemistry |
| Year | 1994 |
| Volume | 33 |
| Pages | 23-32 |
| Authors | Li H, Hallows WH, Punzi JS, Marquez VE, Carrell HL, Pankiewicz KW, Watanabe KA, Goldstein BM |
| Title |
Crystallographic studies of two alcohol dehydrogenase-bound analogues of thiazole-4-carboxamide adenine dinucleotide (TAD), |
| Related PDB | 1adf 1adg |
| Related UniProtKB | |
| [30] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 7918390 |
| Journal | Biochemistry |
| Year | 1994 |
| Volume | 33 |
| Pages | 11734-44 |
| Authors | Li H, Hallows WH, Punzi JS, Pankiewicz KW, Watanabe KA, Goldstein BM |
| Title | Crystallographic studies of isosteric NAD analogues bound to alcohol dehydrogenase: specificity and substrate binding in two ternary complexes. |
| Related PDB | 1adb 1adc |
| Related UniProtKB | |
| [31] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 8172897 |
| Journal | Biochemistry |
| Year | 1994 |
| Volume | 33 |
| Pages | 5230-7 |
| Authors | Ramaswamy S, Eklund H, Plapp BV |
| Title | Structures of horse liver alcohol dehydrogenase complexed with NAD+ and substituted benzyl alcohols. |
| Related PDB | 1hld |
| Related UniProtKB | |
| [32] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7957193 |
| Journal | Eur J Biochem |
| Year | 1994 |
| Volume | 225 |
| Pages | 1015-9 |
| Authors | Jelokova J, Karlsson C, Estonius M, Jornvall H, Hoog JO |
| Title |
Features of structural zinc in mammalian alcohol dehydrogenase. |
| Related PDB | |
| Related UniProtKB | |
| [33] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8032158 |
| Journal | EXS |
| Year | 1994 |
| Volume | 71 |
| Pages | 269-77 |
| Authors | Eklund H, Ramaswamy S, Plapp BV, el-Ahmad M, Danielsson O, Hoog JO, Jornvall H |
| Title | Crystallographic investigations of alcohol dehydrogenases. |
| Related PDB | |
| Related UniProtKB | |
| [34] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS). |
| Medline ID | 94260547 |
| PubMed ID | 8201622 |
| Journal | J Mol Biol |
| Year | 1994 |
| Volume | 239 |
| Pages | 415-29 |
| Authors | Hurley TD, Bosron WF, Stone CL, Amzel LM |
| Title |
Structures of three human beta alcohol dehydrogenase variants. |
| Related PDB | 1hdx 1hdy 1hdz |
| Related UniProtKB | P00325 |
| [35] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8127901 |
| Journal | Proc Natl Acad Sci U S A |
| Year | 1994 |
| Volume | 91 |
| Pages | 1893-7 |
| Authors | Pares X, Cederlund E, Moreno A, Hjelmqvist L, Farres J, Jornvall H |
| Title |
Mammalian class IV alcohol dehydrogenase (stomach alcohol dehydrogenase): structure, |
| Related PDB | |
| Related UniProtKB | |
| [36] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7484400 |
| Journal | Adv Exp Med Biol |
| Year | 1995 |
| Volume | 372 |
| Pages | 365-71 |
| Authors | el-Ahmad M, Ramaswamy S, Danielsson O, Karlsson C, Estonius M, Hoog JO, Eklund H, Jornvall H |
| Title | Crystallizations of novel forms of alcohol dehydrogenase. |
| Related PDB | |
| Related UniProtKB | |
| [37] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7484389 |
| Journal | Adv Exp Med Biol |
| Year | 1995 |
| Volume | 372 |
| Pages | 281-94 |
| Authors | Jornvall H, Danielsson O, Hjelmqvist L, Persson B, Shafqat J |
| Title | The alcohol dehydrogenase system. |
| Related PDB | |
| Related UniProtKB | |
| [38] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7766625 |
| Journal | Biochemistry |
| Year | 1995 |
| Volume | 34 |
| Pages | 7145-53 |
| Authors | Hemmingsen L, Bauer R, Bjerrum MJ, Zeppezauer M, Adolph HW, Formicka G, Cedergren-Zeppezauer E |
| Title | Cd-substituted horse liver alcohol dehydrogenase: catalytic site metal coordination geometry and protein conformation. |
| Related PDB | |
| Related UniProtKB | |
| [39] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7479907 |
| Journal | Proc Natl Acad Sci U S A |
| Year | 1995 |
| Volume | 92 |
| Pages | 10904-8 |
| Authors | Hjelmqvist L, Estonius M, Jornvall H |
| Title | The vertebrate alcohol dehydrogenase system: variable class II type form elucidates separate stages of enzymogenesis. |
| Related PDB | |
| Related UniProtKB | |
| [40] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7549877 |
| Journal | Protein Sci |
| Year | 1995 |
| Volume | 4 |
| Pages | 1124-32 |
| Authors | Ryde U |
| Title | On the role of Glu-68 in alcohol dehydrogenase. |
| Related PDB | |
| Related UniProtKB | |
| [41] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8638928 |
| Journal | Arch Biochem Biophys |
| Year | 1996 |
| Volume | 328 |
| Pages | 173-83 |
| Authors | Edwards KJ, Barton JD, Rossjohn J, Thorn JM, Taylor GL, Ollis DL |
| Title |
Structural and sequence comparisons of quinone oxidoreductase, |
| Related PDB | |
| Related UniProtKB | |
| [42] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8713071 |
| Journal | Biochem J |
| Year | 1996 |
| Volume | 317 |
| Pages | 447-56 |
| Authors | Farrar JA, Formicka G, Zeppezauer M, Thomson AJ |
| Title | Magnetic and optical properties of copper-substituted alcohol dehydrogenase: a bisthiolate copper (II) complex. |
| Related PDB | |
| Related UniProtKB | |
| [43] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8703951 |
| Journal | Biochemistry |
| Year | 1996 |
| Volume | 35 |
| Pages | 9782-91 |
| Authors | Olson LP, Luo J, Almarsson O, Bruice TC |
| Title | Mechanism of aldehyde oxidation catalyzed by horse liver alcohol dehydrogenase. |
| Related PDB | |
| Related UniProtKB | |
| [44] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8695638 |
| Journal | Biochim Biophys Acta |
| Year | 1996 |
| Volume | 1295 |
| Pages | 125-38 |
| Authors | Vanhommerig SA, Sluyterman LA, Meijer EM |
| Title | Kinetic and modelling studies of NAD+ and poly(ethylene glycol)-bound NAD+ in horse liver alcohol dehydrogenase. |
| Related PDB | |
| Related UniProtKB | |
| [45] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8917454 |
| Journal | Eur J Biochem |
| Year | 1996 |
| Volume | 241 |
| Pages | 546-51 |
| Authors | Hemmingsen L, Bauer R, Bjerrum MJ, Adolph HW, Zeppezauer M, Cedergren-Zeppezauer E |
| Title | The protein conformation of Cd-substituted horse liver alcohol dehydrogenase and its metal-site coordination geometry in binary and ternary inhibitor complexes. |
| Related PDB | |
| Related UniProtKB | |
| [46] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8612630 |
| Journal | Eur J Biochem |
| Year | 1996 |
| Volume | 236 |
| Pages | 563-70 |
| Authors | Hjelmqvist L, Shafqat J, Siddiqi AR, Jornvall H |
| Title |
Linking of isozyme and class variability patterns in the emergence of novel alcohol dehydrogenase functions. |
| Related PDB | |
| Related UniProtKB | |
| [47] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8898073 |
| Journal | FEBS Lett |
| Year | 1996 |
| Volume | 395 |
| Pages | 99-102 |
| Authors | Moreno A, Farres J, Pares X, Jornvall H, Persson B |
| Title | Molecular modelling of human gastric alcohol dehydrogenase (class IV) and substrate docking: differences towards the classical liver enzyme (class I). |
| Related PDB | |
| Related UniProtKB | |
| [48] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS). |
| Medline ID | 96291846 |
| PubMed ID | 8663387 |
| Journal | J Biol Chem |
| Year | 1996 |
| Volume | 271 |
| Pages | 17057-61 |
| Authors | Davis GJ, Bosron WF, Stone CL, Owusu-Dekyi K, Hurley TD |
| Title |
X-ray structure of human beta3beta3 alcohol dehydrogenase. |
| Related PDB | 1deh 1htb |
| Related UniProtKB | P00325 |
| [49] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS). |
| Medline ID | 96259224 |
| PubMed ID | 8845755 |
| Journal | Protein Sci |
| Year | 1996 |
| Volume | 5 |
| Pages | 663-71 |
| Authors | Ramaswamy S, el Ahmad M, Danielsson O, Jornvall H, Eklund H |
| Title | Crystal structure of cod liver class I alcohol dehydrogenase: substrate pocket and structurally variable segments. |
| Related PDB | 1cdo |
| Related UniProtKB | P26325 |
| [50] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9059633 |
| Journal | Adv Exp Med Biol |
| Year | 1997 |
| Volume | 414 |
| Pages | 291-302 |
| Authors | Hurley TD, Steinmetz CG, Xie P, Yang ZN |
| Title | Three-dimensional structures of human alcohol dehydrogenase isoenzymes reveal the molecular basis for their functional diversity. |
| Related PDB | |
| Related UniProtKB | |
| [51] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9059632 |
| Journal | Adv Exp Med Biol |
| Year | 1997 |
| Volume | 414 |
| Pages | 281-9 |
| Authors | Jornvall H, Shafqat J, el-Ahmad M, Hjelmqvist L, Persson B, Danielsson O |
| Title |
Alcohol dehydrogenase variability. |
| Related PDB | |
| Related UniProtKB | |
| [52] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9220961 |
| Journal | Biochemistry |
| Year | 1997 |
| Volume | 36 |
| Pages | 8743-54 |
| Authors | Adolph HW, Kiefer M, Cedergren-Zeppezauer E |
| Title | Electrostatic effects in the kinetics of coenzyme binding to isozymes of alcohol dehydrogenase from horse liver. |
| Related PDB | |
| Related UniProtKB | |
| [53] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 9003191 |
| Journal | Biochemistry |
| Year | 1997 |
| Volume | 36 |
| Pages | 382-9 |
| Authors | Cho H, Ramaswamy S, Plapp BV |
| Title | Flexibility of liver alcohol dehydrogenase in stereoselective binding of 3-butylthiolane 1-oxides. |
| Related PDB | 1bto 3bto |
| Related UniProtKB | |
| [54] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 9132002 |
| Journal | Biochemistry |
| Year | 1997 |
| Volume | 36 |
| Pages | 3522-7 |
| Authors | Ramaswamy S, Scholze M, Plapp BV |
| Title | Binding of formamides to liver alcohol dehydrogenase. |
| Related PDB | 1lde 1ldy |
| Related UniProtKB | |
| [55] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 9371755 |
| Journal | Proc Natl Acad Sci U S A |
| Year | 1997 |
| Volume | 94 |
| Pages | 12797-802 |
| Authors | Bahnson BJ, Colby TD, Chin JK, Goldstein BM, Klinman JP |
| Title | A link between protein structure and enzyme catalyzed hydrogen tunneling. |
| Related PDB | 1axe 1axg |
| Related UniProtKB | |
| [56] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9521768 |
| Journal | Biochemistry |
| Year | 1998 |
| Volume | 37 |
| Pages | 4482-9 |
| Authors | Cho H, Plapp BV |
| Title | Specificity of alcohol dehydrogenases for sulfoxides. |
| Related PDB | |
| Related UniProtKB | |
| [57] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 9649310 |
| Journal | Biochemistry |
| Year | 1998 |
| Volume | 37 |
| Pages | 9295-304 |
| Authors | Colby TD, Bahnson BJ, Chin JK, Klinman JP, Goldstein BM |
| Title | Active site modifications in a double mutant of liver alcohol dehydrogenase: structural studies of two enzyme-ligand complexes. |
| Related PDB | 1a71 1a72 |
| Related UniProtKB | |
| [58] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9485460 |
| Journal | Biochemistry |
| Year | 1998 |
| Volume | 37 |
| Pages | 3068-77 |
| Authors | Piersma SR, Visser AJ, de Vries S, Duine JA |
| Title | Optical spectroscopy of nicotinoprotein alcohol dehydrogenase from Amycolatopsis methanolica: a comparison with horse liver alcohol dehydrogenase and UDP-galactose epimerase. |
| Related PDB | |
| Related UniProtKB | |
| [59] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9572895 |
| Journal | J Med Chem |
| Year | 1998 |
| Volume | 41 |
| Pages | 1696-701 |
| Authors | Schindler JF, Berst KB, Plapp BV |
| Title | Inhibition of human alcohol dehydrogenases by formamides. |
| Related PDB | |
| Related UniProtKB | |
| [60] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10352708 |
| Journal | Adv Exp Med Biol |
| Year | 1999 |
| Volume | 463 |
| Pages | 373-7 |
| Authors | Persson B, Nordling E, Kallberg Y, Lundh D, Oppermann UC, Marschall HU, Jornvall H |
| Title | Bioinformatics in studies of SDR and MDR enzymes. |
| Related PDB | |
| Related UniProtKB | |
| [61] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 10529241 |
| Journal | Biochemistry |
| Year | 1999 |
| Volume | 38 |
| Pages | 13951-9 |
| Authors | Ramaswamy S, Park DH, Plapp BV |
| Title | Substitutions in a flexible loop of horse liver alcohol dehydrogenase hinder the conformational change and unmask hydrogen transfer. |
| Related PDB | 1qlh 1qlj |
| Related UniProtKB | |
| [62] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10407146 |
| Journal | Biochim Biophys Acta |
| Year | 1999 |
| Volume | 1432 |
| Pages | 239-50 |
| Authors | Foglio MH, Duester G |
| Title | Molecular docking studies on interaction of diverse retinol structures with human alcohol dehydrogenases predict a broad role in retinoid ligand synthesis. |
| Related PDB | |
| Related UniProtKB | |
| [63] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 11041853 |
| Journal | Biochemistry |
| Year | 2000 |
| Volume | 39 |
| Pages | 12885-97 |
| Authors | Adolph HW, Zwart P, Meijers R, Hubatsch I, Kiefer M, Lamzin V, Cedergren-Zeppezauer E |
| Title | Structural basis for substrate specificity differences of horse liver alcohol dehydrogenase isozymes. |
| Related PDB | 1ee2 |
| Related UniProtKB | |
| [64] | |
| Resource | |
| Comments | Theoretical model |
| Medline ID | |
| PubMed ID | 10733557 |
| Journal | Hepatology |
| Year | 2000 |
| Volume | 31 |
| Pages | 990-6 |
| Authors | Marschall HU, Oppermann UC, Svensson S, Nordling E, Persson B, Hoog JO, Jornvall H |
| Title | Human liver class I alcohol dehydrogenase gammagamma isozyme: the sole cytosolic 3beta-hydroxysteroid dehydrogenase of iso bile acids. |
| Related PDB | 1dda |
| Related UniProtKB | |
| [65] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 11601993 |
| Journal | Biochemistry |
| Year | 2001 |
| Volume | 40 |
| Pages | 12686-94 |
| Authors | Rubach JK, Ramaswamy S, Plapp BV |
| Title | Contributions of valine-292 in the nicotinamide binding site of liver alcohol dehydrogenase and dynamics to catalysis. |
| Related PDB | 1ju9 |
| Related UniProtKB | |
| [66] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11724603 |
| Journal | J Am Chem Soc |
| Year | 2001 |
| Volume | 123 |
| Pages | 11952-9 |
| Authors | Luo J, Bruice TC |
| Title |
Dynamic structures of horse liver alcohol dehydrogenase (HLADH): results of molecular dynamics simulations of HLADH-NAD(+)-PhCH(2)OH, |
| Related PDB | |
| Related UniProtKB | |
| [67] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 11134046 |
| Journal | J Biol Chem |
| Year | 2001 |
| Volume | 276 |
| Pages | 9316-21 |
| Authors | Meijers R, Morris RJ, Adolph HW, Merli A, Lamzin VS, Cedergren-Zeppezauer ES |
| Title | On the enzymatic activation of NADH. |
| Related PDB | 1het 1heu |
| Related UniProtKB | |
| [68] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11173978 |
| Journal | J Biomed Sci |
| Year | 2001 |
| Volume | 8 |
| Pages | 71-6 |
| Authors | Hoog JO, Hedberg JJ, Stromberg P, Svensson S |
| Title | Mammalian alcohol dehydrogenase - functional and structural implications. |
| Related PDB | |
| Related UniProtKB | |
| [69] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 11274460 |
| Journal | Protein Sci |
| Year | 2001 |
| Volume | 10 |
| Pages | 697-706 |
| Authors | Niederhut MS, Gibbons BJ, Perez-Miller S, Hurley TD |
| Title | Three-dimensional structures of the three human class I alcohol dehydrogenases. |
| Related PDB | 1hso 1hsz 1ht0 |
| Related UniProtKB | |
| [70] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12491384 |
| Journal | Angew Chem Int Ed Engl |
| Year | 2002 |
| Volume | 41 |
| Pages | 478-81 |
| Authors | Lo HC, Fish RH |
| Title |
Biomimetic NAD(+) models for tandem cofactor regeneration, |
| Related PDB | |
| Related UniProtKB | |
| [71] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 12501206 |
| Journal | Biochemistry |
| Year | 2002 |
| Volume | 41 |
| Pages | 15770-9 |
| Authors | Rubach JK, Plapp BV |
| Title | Mobility of fluorobenzyl alcohols bound to liver alcohol dehydrogenases as determined by NMR and X-ray crystallographic studies. |
| Related PDB | 1mg0 1mgo |
| Related UniProtKB | |
| [72] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11916410 |
| Journal | J Am Chem Soc |
| Year | 2002 |
| Volume | 124 |
| Pages | 3270-6 |
| Authors | Caratzoulas S, Mincer JS, Schwartz SD |
| Title | Identification of a protein-promoting vibration in the reaction catalyzed by horse liver alcohol dehydrogenase. |
| Related PDB | |
| Related UniProtKB | |
| [73] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11942822 |
| Journal | J Am Chem Soc |
| Year | 2002 |
| Volume | 124 |
| Pages | 3858-64 |
| Authors | Kohen A, Jensen JH |
| Title | Boundary conditions for the Swain-Schaad relationship as a criterion for hydrogen tunneling. |
| Related PDB | |
| Related UniProtKB | |
| [74] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12481026 |
| Journal | Proc Natl Acad Sci U S A |
| Year | 2002 |
| Volume | 99 |
| Pages | 16597-600 |
| Authors | Luo J, Bruice TC |
| Title | Ten-nanosecond molecular dynamics simulation of the motions of the horse liver alcohol dehydrogenase.PhCH2O- complex. |
| Related PDB | |
| Related UniProtKB | |
| [75] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 12627956 |
| Journal | Biochemistry |
| Year | 2003 |
| Volume | 42 |
| Pages | 2907-15 |
| Authors | Rubach JK, Plapp BV |
| Title | Amino acid residues in the nicotinamide binding site contribute to catalysis by horse liver alcohol dehydrogenase. |
| Related PDB | 1n8k 1n92 |
| Related UniProtKB | |
| [76] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 14523561 |
| Journal | Cell Mol Life Sci |
| Year | 2003 |
| Volume | 60 |
| Pages | 2009-16 |
| Authors | Hjelmqvist L, Norin A, El-Ahmad M, Griffiths W, Jornvall H |
| Title | Distinct but parallel evolutionary patterns between alcohol and aldehyde dehydrogenases: addition of fish/human betaine aldehyde dehydrogenase divergence. |
| Related PDB | |
| Related UniProtKB | |
| [77] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 12855684 |
| Journal | J Biol Chem |
| Year | 2003 |
| Volume | 278 |
| Pages | 36699-706 |
| Authors | Venkataramaiah TH, Plapp BV |
| Title | Formamides mimic aldehydes and inhibit liver alcohol dehydrogenases and ethanol metabolism. |
| Related PDB | 1p1r |
| Related UniProtKB | |
| [78] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 15023053 |
| Journal | Biochemistry |
| Year | 2004 |
| Volume | 43 |
| Pages | 3014-26 |
| Authors | LeBrun LA, Park DH, Ramaswamy S, Plapp BV |
| Title | Participation of histidine-51 in catalysis by horse liver alcohol dehydrogenase. |
| Related PDB | 1qv6 1qv7 |
| Related UniProtKB | |
| [79] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 15331786 |
| Journal | Proc Natl Acad Sci U S A |
| Year | 2004 |
| Volume | 101 |
| Pages | 13152-6 |
| Authors | Luo J, Bruice TC |
| Title | Anticorrelated motions as a driving force in enzyme catalysis: the dehydrogenase reaction. |
| Related PDB | |
| Related UniProtKB | |
| Comments |
|---|
|
This enzyme is structurally similar to class III of zinc-containing alcohol dehydrogenase superfamily.
Although this enzyme binds two zinc ions, |
| Created | Updated |
|---|---|
| 2005-01-11 | 2009-02-26 |