DB code: M00329
| RLCP classification | 3.103.130000.1162 : Transfer | |
|---|---|---|
| CATH domain | 2.130.10.10 : Methylamine Dehydrogenase; Chain H | |
| 3.30.1680.10 : ligand-binding face of the semaphorins, domain 2 | ||
| 2.60.40.10 : Immunoglobulin-like | ||
| 2.60.40.10 : Immunoglobulin-like | ||
| 2.60.40.10 : Immunoglobulin-like | ||
| 2.60.40.10 : Immunoglobulin-like | ||
| -.-.-.- : | ||
| -.-.-.- : | ||
| 3.30.200.20 : Phosphorylase Kinase; domain 1 | ||
| 1.10.510.10 : Transferase(Phosphotransferase); domain 1 | Catalytic domain | |
| -.-.-.- : | ||
| E.C. | 2.7.10.1 | |
| CSA | ||
| M-CSA | ||
| MACiE | ||
| CATH domain | Related DB codes (homologues) |
|---|---|
| 1.10.510.10 : Transferase(Phosphotransferase); domain 1 | M00125 M00124 M00131 T00224 M00127 M00129 M00130 M00132 M00136 M00196 M00197 M00198 M00304 M00323 M00325 M00326 M00327 M00328 M00330 M00331 M00332 M00333 M00335 M00339 M00344 |
| 2.130.10.10 : Methylamine Dehydrogenase; Chain H | S00852 D00039 |
| 2.60.40.10 : Immunoglobulin-like | M00131 T00257 T00005 M00113 M00127 M00132 M00323 M00325 M00327 M00330 M00331 M00332 T00307 D00166 D00500 M00112 M00193 T00063 T00065 T00067 T00245 |
| 3.30.200.20 : Phosphorylase Kinase; domain 1 | M00125 M00124 M00131 T00224 M00127 M00129 M00130 M00132 M00136 M00196 M00197 M00198 M00304 M00323 M00325 M00326 M00327 M00328 M00330 M00331 M00332 M00333 M00335 M00339 M00344 D00298 |
| Uniprot Enzyme Name | UniprotKB | Protein name | Synonyms | Contains | RefSeq | Pfam |
|---|---|---|---|---|---|
| Q04912 |
Macrophage-stimulating protein receptor (MSP receptor) (EC 2.7.10.1) (CDw136) (Protein-tyrosine kinase 8) (p185-Ron)AltName: CD_antigen=CD136;
|
None |
Macrophage-stimulating protein receptor alpha chain
Macrophage-stimulating protein receptor beta chain |
NP_001231866.1
(Protein)
NM_001244937.1 (DNA/RNA sequence) NP_002438.2 (Protein) NM_002447.2 (DNA/RNA sequence) |
PF07714
(Pkinase_Tyr)
PF01403 (Sema) PF01833 (TIG) [Graphical View] |
| KEGG enzyme name |
|---|
|
Receptor protein-tyrosine kinase
ATP:protein-tyrosine O-phosphotransferase (ambiguous) MST1R Protein-tyrosine kinase (ambiguous) Protein tyrosine kinase (ambiguous) PTK Receptor protein tyrosine kinase RON |
| UniprotKB: Accession Number | Entry name | Activity | Subunit | Subcellular location | Cofactor |
|---|---|---|---|---|---|
| Q04912 | RON_HUMAN | ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. | Heterodimer of an alpha chain and a beta chain which are disulfide linked. Binds PLXNB1. Associates with and is negatively regulated by HYAL2. Interacts when phosphorylated with downstream effectors including PIK3R1, PCLG1, GRB2 and GAB1. Interacts with integrin beta1/ITGB1 in a ligand-independent fashion. | Membrane, Single-pass type I membrane protein. |
| KEGG Pathways | Map code | Pathways | E.C. |
|---|
| Compound table | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cofactors | Substrates | Products | Intermediates | ||||||||
| KEGG-id | C00305 | C00002 | C00585 | C00008 | C01167 | ||||||
| E.C. | |||||||||||
| Compound | Mg | ATP | [protein]-L-tyrosine | ADP | [protein]-L-tyrosine phosphate | ||||||
| Type | divalent metal (Ca2+, Mg2+) | amine group,nucleotide | aromatic ring (only carbon atom),peptide/protein | amine group,nucleotide | aromatic ring (only carbon atom),peptide/protein,phosphate group/phosphate ion | ||||||
| ChEBI |
18420 18420 |
15422 15422 |
16761 16761 |
||||||||
| PubChem |
888 888 |
5957 5957 |
6022 6022 |
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| 4fwwA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | |
| 4fwwA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3plsA01 |
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Unbound | Unbound | Unbound | Analogue:ANP | Unbound | |
| 3plsA02 |
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Bound:_MG | Unbound | Unbound | Unbound | Unbound | |
| Reference for Active-site residues | ||
|---|---|---|
| resource | references | E.C. |
| Literature [7] & Swiss-prot;Q04912 | ||
| Active-site residues | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Catalytic residues | Cofactor-binding residues | Modified residues | Main-chain involved in catalysis | Comment | |||||
| 4fwwA01 |
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| 4fwwA02 |
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| 3plsA01 |
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| 3plsA02 |
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ASP 1208;ARG 1212 | ASN 1213;ASP 1226(Magnesium binding) | TYR 1238;TYR 1239;TYR 1358 (auto-phosphorylation) | ||
| References for Catalytic Mechanism | ||
|---|---|---|
| References | Sections | No. of steps in catalysis |
|
[7]
|
FIGURE 1 | |
| References | |
|---|---|
| [1] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8062829 |
| Journal | EMBO J |
| Year | 1994 |
| Volume | 13 |
| Pages | 3524-32 |
| Authors | Gaudino G, Follenzi A, Naldini L, Collesi C, Santoro M, Gallo KA, Godowski PJ, Comoglio PM |
| Title | RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP. |
| Related PDB | |
| Related UniProtKB | |
| [2] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7939629 |
| Journal | Science |
| Year | 1994 |
| Volume | 266 |
| Pages | 117-9 |
| Authors | Wang MH, Ronsin C, Gesnel MC, Coupey L, Skeel A, Leonard EJ, Breathnach R |
| Title | Identification of the ron gene product as the receptor for the human macrophage stimulating protein. |
| Related PDB | |
| Related UniProtKB | |
| [3] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10631120 |
| Journal | Biochem Biophys Res Commun |
| Year | 2000 |
| Volume | 267 |
| Pages | 669-75 |
| Authors | Xiao ZQ, Chen YQ, Wang MH |
| Title | Requirement of both tyrosine residues 1330 and 1337 in the C-terminal tail of the RON receptor tyrosine kinase for epithelial cell scattering and migration. |
| Related PDB | |
| Related UniProtKB | |
| [4] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 14597639 |
| Journal | J Biol Chem |
| Year | 2004 |
| Volume | 279 |
| Pages | 3726-32 |
| Authors | Angeloni D, Danilkovitch-Miagkova A, Miagkov A, Leonard EJ, Lerman MI |
| Title | The soluble sema domain of the RON receptor inhibits macrophage-stimulating protein-induced receptor activation. |
| Related PDB | |
| Related UniProtKB | |
| [5] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 15632155 |
| Journal | J Biol Chem |
| Year | 2005 |
| Volume | 280 |
| Pages | 8893-900 |
| Authors | Yokoyama N, Ischenko I, Hayman MJ, Miller WT |
| Title | The C terminus of RON tyrosine kinase plays an autoinhibitory role. |
| Related PDB | |
| Related UniProtKB | |
| [6] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 18950514 |
| Journal | J Exp Clin Cancer Res |
| Year | 2008 |
| Volume | 27 |
| Pages | 55 |
| Authors | Lu Y, Yao HP, Wang MH |
| Title | Significance of the entire C-terminus in biological activities mediated by the RON receptor tyrosine kinase and its oncogenic variant RON160. |
| Related PDB | |
| Related UniProtKB | |
| [7] | |
| Resource | |
| Comments |
X-RAY CRYSTALLOGRAPHY (2.24 ANGSTROMS) OF 1060-1357 IN COMPLEX WITH AMP-PNP AND MAGNESIUM, |
| Medline ID | |
| PubMed ID | 20726546 |
| Journal | Biochemistry |
| Year | 2010 |
| Volume | 49 |
| Pages | 7972-4 |
| Authors | Wang J, Steinbacher S, Augustin M, Schreiner P, Epstein D, Mulvihill MJ, Crew AP |
| Title | The crystal structure of a constitutively active mutant RON kinase suggests an intramolecular autophosphorylation hypothesis. |
| Related PDB | 3pls |
| Related UniProtKB | Q04912 |
| [8] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 22848655 |
| Journal | PLoS One |
| Year | 2012 |
| Volume | 7 |
| Pages | e41912 |
| Authors | Chao KL, Tsai IW, Chen C, Herzberg O |
| Title | Crystal structure of the Sema-PSI extracellular domain of human RON receptor tyrosine kinase. |
| Related PDB | 4fww |
| Related UniProtKB | |
| Comments |
|---|
|
This enzyme is homologous to c-MET (M00322 in EzCatDB).
The catalytic domain of this enzyme is homologous to that of vascular endothelial growth factor receptor (M00131 in EzCatDB). |
| Created | Updated |
|---|---|
| 2011-11-09 | 2012-12-11 |