References
|
[1]
|
Resource
|
|
Comments
|
ACTIVE SITE.
|
Medline ID
|
69283592
|
PubMed ID
|
4897201
|
Journal
|
Biochem J
|
Year
|
1969
|
Volume
|
113
|
Pages
|
377-86
|
Authors
|
Bayliss RS, Knowles JR, Wybrandt GB
|
Title
|
An aspartic acid residue at the active site of pepsin. The isolation and sequence of the heptapeptide.
|
Related PDB
|
|
Related UniProtKB
|
P00791
|
[2]
|
Resource
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Comments
|
|
Medline ID
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|
PubMed ID
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4940603
|
Journal
|
Arch Biochem Biophys
|
Year
|
1971
|
Volume
|
144
|
Pages
|
59-65
|
Authors
|
Nakagawa Y, Perlmann GE
|
Title
|
Disulfide bonds of pepsinogen and pepsin: identification of the disulfide bonds which can be reversibly reduced and reoxidized.
|
Related PDB
|
|
Related UniProtKB
|
|
[3]
|
Resource
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Comments
|
|
Medline ID
|
|
PubMed ID
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4946266
|
Journal
|
Biochem Biophys Res Commun
|
Year
|
1971
|
Volume
|
45
|
Pages
|
293-6
|
Authors
|
Hubbard CD, Stein TP
|
Title
|
The pepsin catalysed hydrolysis of bis-P-nitrophenyl sulfite.
|
Related PDB
|
|
Related UniProtKB
|
|
[4]
|
Resource
|
|
Comments
|
|
Medline ID
|
|
PubMed ID
|
4561920
|
Journal
|
Biochem J
|
Year
|
1972
|
Volume
|
127
|
Pages
|
35P
|
Authors
|
Takahashi M, Hofmann T
|
Title
|
Evidence for an acyl intermediate in pepsin-catalysed reactions.
|
Related PDB
|
|
Related UniProtKB
|
|
[5]
|
Resource
|
|
Comments
|
|
Medline ID
|
|
PubMed ID
|
782445
|
Journal
|
Biochem J
|
Year
|
1976
|
Volume
|
153
|
Pages
|
691-9
|
Authors
|
Wang TT, Hofmann T
|
Title
|
Acyl and amino intermediates in reactions catalysed by pig pepsin. Analysis of transpeptidation products.
|
Related PDB
|
|
Related UniProtKB
|
|
[6]
|
Resource
|
|
Comments
|
X-RAY CRYSTALLOGRAPHY.
|
Medline ID
|
78077917
|
PubMed ID
|
339692
|
Journal
|
Adv Exp Med Biol
|
Year
|
1977
|
Volume
|
95
|
Pages
|
23-31
|
Authors
|
Andreeva NS, Gustchina AE, Fedorov AA, Shutzkever NE, Volnova TV
|
Title
|
X-ray crystallographic studies of pepsin.
|
Related PDB
|
|
Related UniProtKB
|
P00791
|
[7]
|
Resource
|
|
Comments
|
|
Medline ID
|
|
PubMed ID
|
346376
|
Journal
|
FEBS Lett
|
Year
|
1978
|
Volume
|
88
|
Pages
|
87-90
|
Authors
|
Antonov VK, Ginodman LM, Kapitannikov YV, Barshevskaya TN, Gurova AG, Rumsh LD
|
Title
|
Mechanism of pepsin catalysis: general base catalysis by the active-site carboxylate ion.
|
Related PDB
|
|
Related UniProtKB
|
|
[8]
|
Resource
|
|
Comments
|
|
Medline ID
|
|
PubMed ID
|
2862261
|
Journal
|
J Pharm Pharmacol
|
Year
|
1985
|
Volume
|
37
|
Pages
|
396-400
|
Authors
|
Lawton JB, Mekas CI
|
Title
|
The effect of polycations on the activity of pepsin.
|
Related PDB
|
|
Related UniProtKB
|
|
[9]
|
Resource
|
|
Comments
|
|
Medline ID
|
|
PubMed ID
|
3109484
|
Journal
|
Biochim Biophys Acta
|
Year
|
1987
|
Volume
|
913
|
Pages
|
122-30
|
Authors
|
Dunn BM, Valler MJ, Rolph CE, Foundling SI, Jimenez M, Kay J
|
Title
|
The pH dependence of the hydrolysis of chromogenic substrates of the type, Lys-Pro-Xaa-Yaa-Phe-(NO2)Phe-Arg-Leu, by selected aspartic proteinases: evidence for specific interactions in subsites S3 and S2.
|
Related PDB
|
|
Related UniProtKB
|
|
[10]
|
Resource
|
|
Comments
|
|
Medline ID
|
|
PubMed ID
|
3313384
|
Journal
|
Proc Natl Acad Sci U S A
|
Year
|
1987
|
Volume
|
84
|
Pages
|
7009-13
|
Authors
|
Suguna K, Padlan EA, Smith CW, Carlson WD, Davies DR
|
Title
|
Binding of a reduced peptide inhibitor to the aspartic proteinase from Rhizopus chinensis: implications for a mechanism of action.
|
Related PDB
|
|
Related UniProtKB
|
|
[11]
|
Resource
|
|
Comments
|
|
Medline ID
|
|
PubMed ID
|
2492190
|
Journal
|
Biochem Biophys Res Commun
|
Year
|
1989
|
Volume
|
158
|
Pages
|
115-9
|
Authors
|
McPhie P
|
Title
|
A reversible unfolding reaction of swine pepsin; implications for pepsinogen's folding mechanism.
|
Related PDB
|
|
Related UniProtKB
|
|
[12]
|
Resource
|
|
Comments
|
X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
|
Medline ID
|
90317821
|
PubMed ID
|
2115088
|
Journal
|
J Mol Biol
|
Year
|
1990
|
Volume
|
214
|
Pages
|
199-222
|
Authors
|
Cooper JB, Khan G, Taylor G, Tickle IJ, Blundell TL
|
Title
|
X-ray analyses of aspartic proteinases. II. Three-dimensional structure of the hexagonal crystal form of porcine pepsin at 2.3 A resolution.
|
Related PDB
|
5pep
|
Related UniProtKB
|
P00791
|
[13]
|
Resource
|
|
Comments
|
X-ray crystallography
|
Medline ID
|
|
PubMed ID
|
2115087
|
Journal
|
J Mol Biol
|
Year
|
1990
|
Volume
|
214
|
Pages
|
143-70
|
Authors
|
Sielecki AR, Fedorov AA, Boodhoo A, Andreeva NS, James MN
|
Title
|
Molecular and crystal structures of monoclinic porcine pepsin refined at 1.8 A resolution.
|
Related PDB
|
4pep
|
Related UniProtKB
|
|
[14]
|
Resource
|
|
Comments
|
X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
|
Medline ID
|
91017500
|
PubMed ID
|
2217165
|
Journal
|
Proteins
|
Year
|
1990
|
Volume
|
8
|
Pages
|
62-81
|
Authors
|
Abad-Zapatero C, Rydel TJ, Erickson J
|
Title
|
Revised 2.3 A structure of porcine pepsin: evidence for a flexible subdomain.
|
Related PDB
|
3pep
|
Related UniProtKB
|
P00791
|
[15]
|
Resource
|
|
Comments
|
|
Medline ID
|
|
PubMed ID
|
1812734
|
Journal
|
Adv Exp Med Biol
|
Year
|
1991
|
Volume
|
306
|
Pages
|
39-45
|
Authors
|
Andreeva NS, James MN
|
Title
|
Why does pepsin have a negative charge at very low pH? An analysis of conserved charged residues in aspartic proteinases.
|
Related PDB
|
|
Related UniProtKB
|
|
[16]
|
Resource
|
|
Comments
|
|
Medline ID
|
|
PubMed ID
|
2065096
|
Journal
|
Biochim Biophys Acta
|
Year
|
1991
|
Volume
|
1078
|
Pages
|
283-8
|
Authors
|
Makarov AA, Protasevich II, Frank EG, Grishina IB, Bolotina IA, Esipova NG
|
Title
|
The number of cooperative regions (energetic domains) in a pepsin molecule depends on the pH of the medium.
|
Related PDB
|
|
Related UniProtKB
|
|
[17]
|
Resource
|
|
Comments
|
|
Medline ID
|
|
PubMed ID
|
1820069
|
Journal
|
Biomed Biochim Acta
|
Year
|
1991
|
Volume
|
50
|
Pages
|
S94-7
|
Authors
|
Bemquerer MP, Theobaldo FC, Tominaga M
|
Title
|
Pepsin-catalyzed peptide synthesis in biphasic systems.
|
Related PDB
|
|
Related UniProtKB
|
|
[18]
|
Resource
|
|
Comments
|
|
Medline ID
|
|
PubMed ID
|
1820070
|
Journal
|
Biomed Biochim Acta
|
Year
|
1991
|
Volume
|
50
|
Pages
|
S98-101
|
Authors
|
Filippova IYu, Lysogorskaya EN, Anisimova VV, Abdel Malak CA, Lavrenova GI, Stepanov VM
|
Title
|
Pepsin behavior as a catalyst in equilibrium-controlled peptide synthesis.
|
Related PDB
|
|
Related UniProtKB
|
|
[19]
|
Resource
|
|
Comments
|
X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS).
|
Medline ID
|
91278095
|
PubMed ID
|
2056534
|
Journal
|
J Mol Biol
|
Year
|
1991
|
Volume
|
219
|
Pages
|
671-92
|
Authors
|
Sielecki AR, Fujinaga M, Read RJ, James MN
|
Title
|
Refined structure of porcine pepsinogen at 1.8 A resolution.
|
Related PDB
|
2psg
|
Related UniProtKB
|
P00791
|
[20]
|
Resource
|
|
Comments
|
X-ray crystallography
|
Medline ID
|
|
PubMed ID
|
1418819
|
Journal
|
Acta Crystallogr B
|
Year
|
1992
|
Volume
|
48
|
Pages
|
476-88
|
Authors
|
Chen L, Erickson JW, Rydel TJ, Park CH, Neidhart D, Luly J, Abad-Zapatero C
|
Title
|
Structure of a pepsin/renin inhibitor complex reveals a novel crystal packing induced by minor chemical alterations in the inhibitor.
|
Related PDB
|
1psa
|
Related UniProtKB
|
|
[21]
|
Resource
|
|
Comments
|
|
Medline ID
|
|
PubMed ID
|
1428533
|
Journal
|
Int J Pept Protein Res
|
Year
|
1992
|
Volume
|
39
|
Pages
|
443-9
|
Authors
|
Abdel Malak C, Filippova IY, Lysogorskaya EN, Anisimova VV, Lavrenova GI, Stepanov VM
|
Title
|
Pepsin as a catalyst of peptide synthesis. Enzyme co-precipitation with emerging peptide products.
|
Related PDB
|
|
Related UniProtKB
|
|
[22]
|
Resource
|
|
Comments
|
|
Medline ID
|
|
PubMed ID
|
1512263
|
Journal
|
J Biol Chem
|
Year
|
1992
|
Volume
|
267
|
Pages
|
17257-63
|
Authors
|
Lin XL, Lin YZ, Koelsch G, Gustchina A, Wlodawer A, Tang J
|
Title
|
Enzymic activities of two-chain pepsinogen, two-chain pepsin, and the amino-terminal lobe of pepsinogen.
|
Related PDB
|
|
Related UniProtKB
|
|
[23]
|
Resource
|
|
Comments
|
|
Medline ID
|
|
PubMed ID
|
1526982
|
Journal
|
J Biol Chem
|
Year
|
1992
|
Volume
|
267
|
Pages
|
18413-8
|
Authors
|
Lin Y, Fusek M, Lin X, Hartsuck JA, Kezdy FJ, Tang J
|
Title
|
pH dependence of kinetic parameters of pepsin, rhizopuspepsin, and their active-site hydrogen bond mutants.
|
Related PDB
|
|
Related UniProtKB
|
|
[24]
|
Resource
|
|
Comments
|
X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS).
|
Medline ID
|
92279205
|
PubMed ID
|
1594574
|
Journal
|
Proteins
|
Year
|
1992
|
Volume
|
13
|
Pages
|
1-25
|
Authors
|
Hartsuck JA, Koelsch G, Remington SJ
|
Title
|
The high-resolution crystal structure of porcine pepsinogen.
|
Related PDB
|
3psg
|
Related UniProtKB
|
P00791
|
[25]
|
Resource
|
|
Comments
|
|
Medline ID
|
|
PubMed ID
|
8461297
|
Journal
|
Biochemistry
|
Year
|
1993
|
Volume
|
32
|
Pages
|
3325-33
|
Authors
|
Beveridge AJ, Heywood GC
|
Title
|
A quantum mechanical study of the active site of aspartic proteinases.
|
Related PDB
|
|
Related UniProtKB
|
|
[26]
|
Resource
|
|
Comments
|
|
Medline ID
|
|
PubMed ID
|
8401224
|
Journal
|
Protein Sci
|
Year
|
1993
|
Volume
|
2
|
Pages
|
1383-90
|
Authors
|
Lin X, Loy JA, Sussman F, Tang J
|
Title
|
Conformational instability of the N- and C-terminal lobes of porcine pepsin in neutral and alkaline solutions.
|
Related PDB
|
|
Related UniProtKB
|
|
[27]
|
Resource
|
|
Comments
|
|
Medline ID
|
|
PubMed ID
|
7925992
|
Journal
|
FEBS Lett
|
Year
|
1994
|
Volume
|
352
|
Pages
|
315-7
|
Authors
|
Iliadis G, Zundel G, Brzezinski B
|
Title
|
Aspartic proteinases--Fourier transform IR studies of the aspartic carboxylic groups in the active site of pepsin.
|
Related PDB
|
|
Related UniProtKB
|
|
[28]
|
Resource
|
|
Comments
|
|
Medline ID
|
|
PubMed ID
|
8138045
|
Journal
|
Int J Biochem
|
Year
|
1994
|
Volume
|
26
|
Pages
|
35-42
|
Authors
|
Balbaa M, Blum M, Hofmann T
|
Title
|
Mechanism of pepsin-catalyzed aminotranspeptidation reactions.
|
Related PDB
|
|
Related UniProtKB
|
|
[29]
|
Resource
|
|
Comments
|
|
Medline ID
|
|
PubMed ID
|
7896503
|
Journal
|
Int J Pept Protein Res
|
Year
|
1994
|
Volume
|
44
|
Pages
|
448-56
|
Authors
|
Bemquerer MP, Adlercreutz P, Tominaga M
|
Title
|
Pepsin-catalyzed peptide synthesis in organic media: studies with free and immobilized enzyme.
|
Related PDB
|
|
Related UniProtKB
|
|
[30]
|
Resource
|
|
Comments
|
|
Medline ID
|
|
PubMed ID
|
8540318
|
Journal
|
Adv Exp Med Biol
|
Year
|
1995
|
Volume
|
362
|
Pages
|
19-32
|
Authors
|
Andreeva NS, Bochkarev A, Pechik I
|
Title
|
A new way of looking at aspartic proteinase structures: a comparison of pepsin structure to other aspartic proteinases in the near active site region.
|
Related PDB
|
|
Related UniProtKB
|
|
[31]
|
Resource
|
|
Comments
|
|
Medline ID
|
|
PubMed ID
|
8540385
|
Journal
|
Adv Exp Med Biol
|
Year
|
1995
|
Volume
|
362
|
Pages
|
91-4
|
Authors
|
Rao C, Dunn BM
|
Title
|
Evidence for electrostatic interactions in the S2 subsite of porcine pepsin.
|
Related PDB
|
|
Related UniProtKB
|
|
[32]
|
Resource
|
|
Comments
|
|
Medline ID
|
|
PubMed ID
|
8556555
|
Journal
|
Clin Exp Allergy
|
Year
|
1995
|
Volume
|
25
|
Pages
|
1007-17
|
Authors
|
Schmidt DG, Meijer RJ, Slangen CJ, van Beresteijn EC
|
Title
|
Raising the pH of the pepsin-catalysed hydrolysis of bovine whey proteins increases the antigenicity of the hydrolysates.
|
Related PDB
|
|
Related UniProtKB
|
|
[33]
|
Resource
|
|
Comments
|
|
Medline ID
|
|
PubMed ID
|
7650014
|
Journal
|
J Biol Chem
|
Year
|
1995
|
Volume
|
270
|
Pages
|
19974-8
|
Authors
|
Cottrell TJ, Harris LJ, Tanaka T, Yada RY
|
Title
|
The sole lysine residue in porcine pepsin works as a key residue for catalysis and conformational flexibility.
|
Related PDB
|
|
Related UniProtKB
|
|
[34]
|
Resource
|
|
Comments
|
|
Medline ID
|
|
PubMed ID
|
7593830
|
Journal
|
J Dairy Res
|
Year
|
1995
|
Volume
|
62
|
Pages
|
451-67
|
Authors
|
Plowman JE, Creamer LK
|
Title
|
Restrained molecular dynamics study of the interaction between bovine kappa-casein peptide 98-111 and bovine chymosin and porcine pepsin.
|
Related PDB
|
|
Related UniProtKB
|
|
[35]
|
Resource
|
|
Comments
|
X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
|
Medline ID
|
95392399
|
PubMed ID
|
7663352
|
Journal
|
Protein Sci
|
Year
|
1995
|
Volume
|
4
|
Pages
|
960-72
|
Authors
|
Fujinaga M, Chernaia MM, Tarasova NI, Mosimann SC, James MN
|
Title
|
Crystal structure of human pepsin and its complex with pepstatin.
|
Related PDB
|
1psn
1pso
|
Related UniProtKB
|
P00790
|
[36]
|
Resource
|
|
Comments
|
|
Medline ID
|
|
PubMed ID
|
8907496
|
Journal
|
Int J Pept Protein Res
|
Year
|
1996
|
Volume
|
47
|
Pages
|
28-35
|
Authors
|
Anisimova VV, Filippova IY, Lysogorskaya EN, Oksenoit ES, Kolobanova SV, Stepanov VM
|
Title
|
Proteinase-catalyzed peptide synthesis in concentrated solutions of urea and other denaturing agents.
|
Related PDB
|
|
Related UniProtKB
|
|
[37]
|
Resource
|
|
Comments
|
|
Medline ID
|
|
PubMed ID
|
9228062
|
Journal
|
J Biol Chem
|
Year
|
1997
|
Volume
|
272
|
Pages
|
18855-61
|
Authors
|
Shintani T, Nomura K, Ichishima E
|
Title
|
Engineering of porcine pepsin. Alteration of S1 substrate specificity of pepsin to those of fungal aspartic proteinases by site-directed mutagenesis.
|
Related PDB
|
|
Related UniProtKB
|
|
[38]
|
Resource
|
|
Comments
|
X-ray crystallography
|
Medline ID
|
|
PubMed ID
|
9761815
|
Journal
|
Acta Crystallogr D Biol Crystallogr
|
Year
|
1998
|
Volume
|
54
|
Pages
|
32-46
|
Authors
|
Karlsen S, Hough E, Olsen RL
|
Title
|
Structure and proposed amino-acid sequence of a pepsin from atlantic cod (Gadus morhua).
|
Related PDB
|
1am5
|
Related UniProtKB
|
|
[39]
|
Resource
|
|
Comments
|
|
Medline ID
|
|
PubMed ID
|
10408333
|
Journal
|
J Pept Res
|
Year
|
1999
|
Volume
|
53
|
Pages
|
606-10
|
Authors
|
Malak CA
|
Title
|
Pepsin as a catalyst for peptide synthesis: formation of peptide bonds not typical for pepsin substrate specificity.
|
Related PDB
|
|
Related UniProtKB
|
|
[40]
|
Resource
|
|
Comments
|
|
Medline ID
|
|
PubMed ID
|
10065711
|
Journal
|
Protein Eng
|
Year
|
1999
|
Volume
|
12
|
Pages
|
55-61
|
Authors
|
Okoniewska M, Tanaka T, Yada RY
|
Title
|
The role of the flap residue, threonine 77, in the activation and catalytic activity of pepsin A.
|
Related PDB
|
|
Related UniProtKB
|
|
[41]
|
Resource
|
|
Comments
|
X-ray crystallography
|
Medline ID
|
|
PubMed ID
|
10713513
|
Journal
|
Acta Crystallogr D Biol Crystallogr
|
Year
|
2000
|
Volume
|
56
|
Pages
|
272-9
|
Authors
|
Fujinaga M, Cherney MM, Tarasova NI, Bartlett PA, Hanson JE, James MN
|
Title
|
Structural study of the complex between human pepsin and a phosphorus-containing peptidic -transition-state analog.
|
Related PDB
|
1qrp
|
Related UniProtKB
|
|
[42]
|
Resource
|
|
Comments
|
|
Medline ID
|
|
PubMed ID
|
10861225
|
Journal
|
Biochem J
|
Year
|
2000
|
Volume
|
349
|
Pages
|
169-77
|
Authors
|
Okoniewska M, Tanaka T, Yada RY
|
Title
|
The pepsin residue glycine-76 contributes to active-site loop flexibility and participates in catalysis.
|
Related PDB
|
|
Related UniProtKB
|
|
[43]
|
Resource
|
|
Comments
|
X-ray crystallography
|
Medline ID
|
|
PubMed ID
|
10932249
|
Journal
|
Nat Struct Biol
|
Year
|
2000
|
Volume
|
7
|
Pages
|
653-7
|
Authors
|
Ng KK, Petersen JF, Cherney MM, Garen C, Zalatoris JJ, Rao-Naik C, Dunn BM, Martzen MR, Peanasky RJ, James MN
|
Title
|
Structural basis for the inhibition of porcine pepsin by Ascaris pepsin inhibitor-3.
|
Related PDB
|
1f34
|
Related UniProtKB
|
|
[44]
|
Resource
|
|
Comments
|
X-ray crystallography
|
Medline ID
|
|
PubMed ID
|
11679720
|
Journal
|
Acta Crystallogr D Biol Crystallogr
|
Year
|
2001
|
Volume
|
57
|
Pages
|
1560-70
|
Authors
|
Canduri F, Teodoro LG, Fadel V, Lorenzi CC, Hial V, Gomes RA, Neto JR, de Azevedo WF Jr
|
Title
|
Structure of human uropepsin at 2.45 A resolution.
|
Related PDB
|
1flh
|
Related UniProtKB
|
|
[45]
|
Resource
|
|
Comments
|
|
Medline ID
|
|
PubMed ID
|
11707613
|
Journal
|
Protein Eng
|
Year
|
2001
|
Volume
|
14
|
Pages
|
669-74
|
Authors
|
Tanaka T, Yada RY
|
Title
|
N-terminal portion acts as an initiator of the inactivation of pepsin at neutral pH.
|
Related PDB
|
|
Related UniProtKB
|
|
[46]
|
Resource
|
|
Comments
|
|
Medline ID
|
|
PubMed ID
|
11714911
|
Journal
|
Protein Sci
|
Year
|
2001
|
Volume
|
10
|
Pages
|
2439-50
|
Authors
|
Andreeva NS, Rumsh LD
|
Title
|
Analysis of crystal structures of aspartic proteinases: on the role of amino acid residues adjacent to the catalytic site of pepsin-like enzymes.
|
Related PDB
|
|
Related UniProtKB
|
|
[47]
|
Resource
|
|
Comments
|
|
Medline ID
|
|
PubMed ID
|
12089768
|
Journal
|
Q Rev Biol
|
Year
|
2002
|
Volume
|
77
|
Pages
|
127-47
|
Authors
|
Fruton JS
|
Title
|
A history of pepsin and related enzymes.
|
Related PDB
|
|
Related UniProtKB
|
|