DB code: T00253
| RLCP classification | 1.12.30000.10 : Hydrolysis | |
|---|---|---|
| CATH domain | 3.40.50.1820 : Rossmann fold | Catalytic domain |
| 2.60.60.20 : Lipoxygenase-1 | ||
| 2.10.80.10 : Lipase, subunit A | ||
| E.C. | 3.1.1.3 | |
| CSA | 1hpl | |
| M-CSA | 1hpl | |
| MACiE | M0218 | |
| CATH domain | Related DB codes (homologues) |
|---|---|
| 2.60.60.20 : Lipoxygenase-1 | M00041 |
| 3.40.50.1820 : Rossmann fold | S00544 S00344 S00517 S00525 S00526 S00720 S00723 S00724 S00725 S00919 S00057 S00374 S00345 S00347 S00348 S00346 S00350 S00352 S00353 S00355 S00356 S00358 D00189 D00210 D00539 |
| Uniprot Enzyme Name | UniprotKB | Protein name | Synonyms | Pfam | RefSeq |
|---|---|---|---|---|
| P81139 |
Pancreatic lipase-related protein 2
|
PL-RP2
EC 3.1.1.3 GPL |
PF00151
(Lipase)
PF01477 (PLAT) [Graphical View] |
|
| P54318 |
Pancreatic lipase-related protein 2
|
PL-RP2
EC 3.1.1.3 Secretory glycoprotein GP-3 |
PF00151
(Lipase)
PF01477 (PLAT) [Graphical View] |
NP_476554.1
(Protein)
NM_057206.1 (DNA/RNA sequence) |
| P00591 |
Pancreatic triacylglycerol lipase
|
Pancreatic lipase
PL EC 3.1.1.3 |
PF00151
(Lipase)
PF01477 (PLAT) [Graphical View] |
|
| P29183 |
Pancreatic triacylglycerol lipase
|
Pancreatic lipase
PL EC 3.1.1.3 |
PF00151
(Lipase)
PF01477 (PLAT) [Graphical View] |
NP_001157421.1
(Protein)
NM_001163949.1 (DNA/RNA sequence) |
| P06857 |
Pancreatic lipase-related protein 1
|
PL-RP1
EC 3.1.1.3 |
PF00151
(Lipase)
PF01477 (PLAT) [Graphical View] |
NP_001003319.2
(Protein)
NM_001003319.2 (DNA/RNA sequence) |
| P16233 |
Pancreatic triacylglycerol lipase
|
Pancreatic lipase
PL EC 3.1.1.3 |
PF00151
(Lipase)
PF01477 (PLAT) [Graphical View] |
NP_000927.1
(Protein)
NM_000936.2 (DNA/RNA sequence) |
| P17084 |
Colipase
|
None |
PF01114
(Colipase)
PF02740 (Colipase_C) [Graphical View] |
NP_037271.1
(Protein)
NM_013139.1 (DNA/RNA sequence) |
| P02703 |
Colipase
|
Procolipase II
|
PF01114
(Colipase)
PF02740 (Colipase_C) [Graphical View] |
NP_999368.1
(Protein)
NM_214203.1 (DNA/RNA sequence) |
| P02704 |
Colipase A
|
None |
PF01114
(Colipase)
PF02740 (Colipase_C) [Graphical View] |
|
| P02705 |
Colipase B
|
None |
PF01114
(Colipase)
PF02740 (Colipase_C) [Graphical View] |
|
| P19090 |
Colipase
|
None |
PF01114
(Colipase)
PF02740 (Colipase_C) [Graphical View] |
NP_001003287.1
(Protein)
NM_001003287.1 (DNA/RNA sequence) |
| P04118 |
Colipase
|
None |
PF01114
(Colipase)
PF02740 (Colipase_C) [Graphical View] |
NP_001823.1
(Protein)
NM_001832.3 (DNA/RNA sequence) |
| KEGG enzyme name |
|---|
|
triacylglycerol lipase
lipase triglyceride lipase tributyrase butyrinase glycerol ester hydrolase tributyrinase Tween hydrolase steapsin triacetinase tributyrin esterase Tweenase amno N-AP Takedo 1969-4-9 Meito MY 30 Tweenesterase GA 56 capalase L triglyceride hydrolase triolein hydrolase tween-hydrolyzing esterase amano CE cacordase triglyceridase triacylglycerol ester hydrolase amano P amano AP PPL glycerol-ester hydrolase GEH meito Sangyo OF lipase hepatic lipase lipazin post-heparin plasma protamine-resistant lipase salt-resistant post-heparin lipase heparin releasable hepatic lipase amano CES amano B tributyrase triglyceride lipase liver lipase hepatic monoacylglycerol acyltransferase |
| UniprotKB: Accession Number | Entry name | Activity | Subunit | Subcellular location | Cofactor |
|---|---|---|---|---|---|
| P81139 | LIPR2_CAVPO | Triacylglycerol + H(2)O = diacylglycerol + a carboxylate. | Secreted. | ||
| P54318 | LIPR2_RAT | Triacylglycerol + H(2)O = diacylglycerol + a carboxylate. | Secreted. Membrane. | ||
| P00591 | LIPP_PIG | Triacylglycerol + H(2)O = diacylglycerol + a carboxylate. | Secreted. | ||
| P29183 | LIPP_HORSE | Triacylglycerol + H(2)O = diacylglycerol + a carboxylate. | Secreted. | ||
| P06857 | LIPR1_CANFA | Triacylglycerol + H(2)O = diacylglycerol + a carboxylate. | Secreted. | ||
| P16233 | LIPP_HUMAN | Triacylglycerol + H(2)O = diacylglycerol + a carboxylate. | Secreted. | ||
| P17084 | COL_RAT | Forms a 1:1 stoichiometric complex with pancreatic lipase (By similarity). | Secreted. | ||
| P02703 | COL_PIG | Forms a 1:1 stoichiometric complex with pancreatic lipase. | Secreted. | ||
| P02704 | COLA_HORSE | Forms a 1:1 stoichiometric complex with pancreatic lipase. | Secreted. | ||
| P02705 | COLB_HORSE | Forms a 1:1 stoichiometric complex with pancreatic lipase. | Secreted. | ||
| P19090 | COL_CANFA | Forms a 1:1 stoichiometric complex with pancreatic lipase. | Secreted. | ||
| P04118 | COL_HUMAN | Forms a 1:1 stoichiometric complex with pancreatic lipase. | Secreted. |
| KEGG Pathways | Map code | Pathways | E.C. |
|---|---|---|
| MAP00561 | Glycerolipid metabolism |
| Compound table | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cofactors | Substrates | Products | Intermediates | |||||||||||
| KEGG-id | C00076 | C00422 | C00001 | C00060 | C00162 | C00165 | I00123 | I00085 | I00086 | |||||
| E.C. | ||||||||||||||
| Compound | Calcium | Triacylglycerol | H2O | Carboxylate | Fatty acid | Diacylglycerol | Peptidyl-Ser-tetrahedral intermediate (with previous carboxylic-ester) | Acyl-enzyme(Peptidyl-Ser-acyl group) | Peptidyl-Ser-tetrahedral-intermediate | |||||
| Type | divalent metal (Ca2+, Mg2+) | carbohydrate,lipid | H2O | carboxyl group | fatty acid | carbohydrate,lipid | ||||||||
| ChEBI |
29108 29108 |
15377 15377 |
||||||||||||
| PubChem |
271 271 |
22247451 962 22247451 962 |
||||||||||||
| 1gplA01 |
|
|
|
|
|
Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1bu8A01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ethA01 |
|
|
|
|
|
Bound:_CA | Unbound | Unbound | Unbound | Analogue:C8E-C8E | Unbound | Unbound | Unbound | |
| 1ethC01 |
|
|
|
|
|
Bound:_CA | Unbound | Unbound | Unbound | Analogue:C8E-C8E | Unbound | Unbound | Unbound | |
| 1hplA01 |
|
|
|
|
|
Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1hplB01 |
|
|
|
|
|
Bound:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1rp1A01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1lpaB01 |
|
|
|
|
|
Bound:_CA | Analogue:PLC | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1lpbB01 |
|
|
|
|
|
Bound:_CA | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:MUP | Unbound | Unbound | |
| 1n8sA01 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1gplA02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1bu8A02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ethA02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ethC02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1hplA02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1hplB02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1rp1A02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1lpaB02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1lpbB02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n8sA02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ethB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ethD |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1lpaA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1lpbA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n8sC |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1pcnA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1pcoA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| Reference for Active-site residues | ||
|---|---|---|
| resource | references | E.C. |
| Swiss-prot;P00591, P06857, P16233, P29183, P54318 & literature [11] | ||
| Active-site residues | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Catalytic residues | Cofactor-binding residues | Modified residues | Main-chain involved in catalysis | Comment | |||||
| 1gplA01 |
|
|
|
|
|
SER 152;ASP 176;HIS 263 | GLU 187;ARG 190;ASP 192;ASP 195(Calcium binding) | PHE 77;LEU 153 | ||
| 1bu8A01 |
|
|
|
|
|
SER 152;ASP 176;HIS 263 | GLU 187;ARG 190;ASP 192;ASP 195(Calcium binding) | PHE 77;LEU 153 | ||
| 1ethA01 |
|
|
|
|
|
SER 153;ASP 177;HIS 264 | GLU 188;ARG 191;ASP 193;ASP 196(Calcium binding) | PHE 78;LEU 154 | ||
| 1ethC01 |
|
|
|
|
|
SER 153;ASP 177;HIS 264 | GLU 188;ARG 191;ASP 193;ASP 196(Calcium binding) | PHE 78;LEU 154 | ||
| 1hplA01 |
|
|
|
|
|
SER 152;ASP 176;HIS 263 | GLU 187;ARG 190;ASP 192;ASP 195(Calcium binding) | PHE 77;LEU 153 | ||
| 1hplB01 |
|
|
|
|
|
SER 152;ASP 176;HIS 263 | GLU 187;ARG 190;ASP 192;ASP 195(Calcium binding) | PHE 77;LEU 153 | ||
| 1rp1A01 |
|
|
|
|
|
SER 152;ASP 176;HIS 263 | GLU 187;ARG 190;ASP 192;ASP 195(Calcium binding) | PHE 77;LEU 153 | ||
| 1lpaB01 |
|
|
|
|
|
SER 152;ASP 176;HIS 263 | GLU 187;ARG 190;ASP 192;ASP 195(Calcium binding) | PHE 77;LEU 153 | ||
| 1lpbB01 |
|
|
|
|
|
SER 152;ASP 176;HIS 263 | GLU 187;ARG 190;ASP 192;ASP 195(Calcium binding) | PHE 77;LEU 153 | ||
| 1n8sA01 |
|
|
|
|
|
SER 152;ASP 176;HIS 263 | GLU 187;ARG 190;ASP 192;ASP 195(Calcium binding) | PHE 77;LEU 153 | ||
| 1gplA02 |
|
|
|
|
|
|||||
| 1bu8A02 |
|
|
|
|
|
|||||
| 1ethA02 |
|
|
|
|
|
|||||
| 1ethC02 |
|
|
|
|
|
|||||
| 1hplA02 |
|
|
|
|
|
|||||
| 1hplB02 |
|
|
|
|
|
|||||
| 1rp1A02 |
|
|
|
|
|
|||||
| 1lpaB02 |
|
|
|
|
|
|||||
| 1lpbB02 |
|
|
|
|
|
|||||
| 1n8sA02 |
|
|
|
|
|
|||||
| 1ethB |
|
|
|
|
|
|||||
| 1ethD |
|
|
|
|
|
|||||
| 1lpaA |
|
|
|
|
|
|||||
| 1lpbA |
|
|
|
|
|
|||||
| 1n8sC |
|
|
|
|
|
|||||
| 1pcnA |
|
|
|
|
|
|||||
| 1pcoA |
|
|
|
|
|
|||||
| References for Catalytic Mechanism | ||
|---|---|---|
| References | Sections | No. of steps in catalysis |
|
[2]
|
||
|
[6]
|
Fig.7, p.99-103 | |
|
[11]
|
p.817 | |
|
[14]
|
p.720-722 | |
|
[15]
|
Fig.3, p.468 | |
|
[17]
|
||
| References | |
|---|---|
| [1] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 2322552 |
| Journal | Biochemistry |
| Year | 1990 |
| Volume | 29 |
| Pages | 1136-42 |
| Authors | Deckelbaum RJ, Hamilton JA, Moser A, Bengtsson-Olivecrona G, Butbul E, Carpentier YA, Gutman A, Olivecrona T |
| Title | Medium-chain versus long-chain triacylglycerol emulsion hydrolysis by lipoprotein lipase and hepatic lipase: implications for the mechanisms of lipase action. |
| Related PDB | |
| Related UniProtKB | |
| [2] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS). |
| Medline ID | 90158821 |
| PubMed ID | 2106079 |
| Journal | Nature |
| Year | 1990 |
| Volume | 343 |
| Pages | 771-4 |
| Authors | Winkler FK, D'Arcy A, Hunziker W |
| Title | Structure of human pancreatic lipase. |
| Related PDB | |
| Related UniProtKB | P16233 |
| [3] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1940628 |
| Journal | J Lipid Res |
| Year | 1991 |
| Volume | 32 |
| Pages | 963-75 |
| Authors | Komaromy MC, Reed M |
| Title | Expression of rat hepatic lipase in heterologous systems: evidence for different sites for interface binding and catalysis. |
| Related PDB | |
| Related UniProtKB | |
| [4] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 2046751 |
| Journal | Nature |
| Year | 1991 |
| Volume | 351 |
| Pages | 491-4 |
| Authors | Brzozowski AM, Derewenda U, Derewenda ZS, Dodson GG, Lawson DM, Turkenburg JP, Bjorkling F, Huge-Jensen B, Patkar SA, Thim L |
| Title | A model for interfacial activation in lipases from the structure of a fungal lipase-inhibitor complex. |
| Related PDB | |
| Related UniProtKB | |
| [5] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1368796 |
| Journal | Enzyme Microb Technol |
| Year | 1992 |
| Volume | 14 |
| Pages | 426-46 |
| Authors | Malcata FX, Reyes HR, Garcia HS, Hill CG Jr, Amundson CH |
| Title | Kinetics and mechanisms of reactions catalysed by immobilized lipases. |
| Related PDB | |
| Related UniProtKB | |
| [6] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1290943 |
| Journal | Faraday Discuss |
| Year | 1992 |
| Volume | -93 |
| Pages | 95-105 |
| Authors | Dodson GG, Lawson DM, Winkler FK |
| Title | Structural and evolutionary relationships in lipase mechanism and activation. |
| Related PDB | |
| Related UniProtKB | |
| [7] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1544468 |
| Journal | FEBS Lett |
| Year | 1992 |
| Volume | 299 |
| Pages | 111-5 |
| Authors | Luthi-Peng Q, Marki HP, Hadvary P |
| Title | Identification of the active-site serine in human pancreatic lipase by chemical modification with tetrahydrolipstatin. |
| Related PDB | |
| Related UniProtKB | |
| [8] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS). |
| Medline ID | 92396238 |
| PubMed ID | 1522902 |
| Journal | Nature |
| Year | 1992 |
| Volume | 359 |
| Pages | 159-62 |
| Authors | van Tilbeurgh H, Sarda L, Verger R, Cambillau C |
| Title | Structure of the pancreatic lipase-procolipase complex. |
| Related PDB | |
| Related UniProtKB | P16233 |
| [9] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8409770 |
| Journal | J Lipid Res |
| Year | 1993 |
| Volume | 34 |
| Pages | 1393-40 |
| Authors | Dichek HL, Parrott C, Ronan R, Brunzell JD, Brewer HB Jr, Santamarina-Fojo S |
| Title | Functional characterization of a chimeric lipase genetically engineered from human lipoprotein lipase and human hepatic lipase. |
| Related PDB | |
| Related UniProtKB | |
| [10] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8301235 |
| Journal | J Lipid Res |
| Year | 1993 |
| Volume | 34 |
| Pages | 2169-76 |
| Authors | Wolle J, Jansen H, Smith LC, Chan L |
| Title | Functional role of N-linked glycosylation in human hepatic lipase: asparagine-56 is important for both enzyme activity and secretion. |
| Related PDB | |
| Related UniProtKB | |
| [11] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS). |
| Medline ID | 93241293 |
| PubMed ID | 8479519 |
| Journal | Nature |
| Year | 1993 |
| Volume | 362 |
| Pages | 814-20 |
| Authors | van Tilbeurgh H, Egloff MP, Martinez C, Rugani N, Verger R, Cambillau C |
| Title | Interfacial activation of the lipase-procolipase complex by mixed micelles revealed by X-ray crystallography. |
| Related PDB | |
| Related UniProtKB | P16233 |
| [12] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7918595 |
| Journal | Biochim Biophys Acta |
| Year | 1994 |
| Volume | 1214 |
| Pages | 148-60 |
| Authors | van Kuiken BA, Behnke WD |
| Title | The activation of porcine pancreatic lipase by cis-unsaturated fatty acids. |
| Related PDB | |
| Related UniProtKB | |
| [13] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7929247 |
| Journal | J Biol Chem |
| Year | 1994 |
| Volume | 269 |
| Pages | 25470-4 |
| Authors | Jennens ML, Lowe ME |
| Title | A surface loop covering the active site of human pancreatic lipase influences interfacial activation and lipid binding. |
| Related PDB | |
| Related UniProtKB | |
| [14] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) |
| Medline ID | 94238688 |
| PubMed ID | 8182745 |
| Journal | J Mol Biol |
| Year | 1994 |
| Volume | 238 |
| Pages | 709-32 |
| Authors | Bourne Y, Martinez C, Kerfelec B, Lombardo D, Chapus C, Cambillau C |
| Title |
Horse pancreatic lipase. |
| Related PDB | 1hpl |
| Related UniProtKB | P29183 |
| [15] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7765546 |
| Journal | Trends Biotechnol |
| Year | 1994 |
| Volume | 12 |
| Pages | 464-72 |
| Authors | Kazlauskas RJ |
| Title | Elucidating structure-mechanism relationships in lipases: prospects for predicting and engineering catalytic properties. |
| Related PDB | |
| Related UniProtKB | |
| [16] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7785848 |
| Journal | Ann N Y Acad Sci |
| Year | 1995 |
| Volume | 750 |
| Pages | 190-4 |
| Authors | Verger R, Ferrato F, Carriere F, Cudrey C, Rugani N, Gargouri Y, Hjorth A, Woldike H, Boel E, Thim L, et al |
| Title | Relationships between structures and kinetic properties of pancreatic lipases. |
| Related PDB | |
| Related UniProtKB | |
| [17] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 7893686 |
| Journal | Biochemistry |
| Year | 1995 |
| Volume | 34 |
| Pages | 2751-62 |
| Authors | Egloff MP, Marguet F, Buono G, Verger R, Cambillau C, van Tilbeurgh H |
| Title | The 2.46 A resolution structure of the pancreatic lipase-colipase complex inhibited by a C11 alkyl phosphonate. |
| Related PDB | 1lpb |
| Related UniProtKB | |
| [18] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9704093 |
| Journal | Biotechnol Annu Rev |
| Year | 1995 |
| Volume | 1 |
| Pages | 315-71 |
| Authors | Anthonsen HW, Baptista A, Drablos F, Martel P, Petersen SB, Sebastiao M, Vaz L |
| Title |
Lipases and esterases: a review of their sequences, |
| Related PDB | |
| Related UniProtKB | |
| [19] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7579978 |
| Journal | EXS |
| Year | 1995 |
| Volume | 73 |
| Pages | 3-26 |
| Authors | Carriere F, Verger R, Lookene A, Olivecrona G |
| Title | Lipase structures at the interface between chemistry and biochemistry. |
| Related PDB | |
| Related UniProtKB | |
| [20] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7533157 |
| Journal | J Biol Chem |
| Year | 1995 |
| Volume | 270 |
| Pages | 3932-7 |
| Authors | Aoubala M, de la Fourniere L, Douchet I, Abousalham A, Daniel C, Hirn M, Gargouri Y, Verger R, De Caro A |
| Title |
Human pancreatic lipase. |
| Related PDB | |
| Related UniProtKB | |
| [21] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7658150 |
| Journal | J Lipid Res |
| Year | 1995 |
| Volume | 36 |
| Pages | 1029-36 |
| Authors | Jennens ML, Lowe ME |
| Title | C-terminal domain of human pancreatic lipase is required for stability and maximal activity but not colipase reactivation. |
| Related PDB | |
| Related UniProtKB | |
| [22] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7773176 |
| Journal | Protein Sci |
| Year | 1995 |
| Volume | 4 |
| Pages | 44-57 |
| Authors | Egloff MP, Sarda L, Verger R, Cambillau C, van Tilbeurgh H |
| Title | Crystallographic study of the structure of colipase and of the interaction with pancreatic lipase. |
| Related PDB | |
| Related UniProtKB | |
| [23] | |
| Resource | |
| Comments |
X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS), |
| Medline ID | 96279347 |
| PubMed ID | 8663362 |
| Journal | J Biol Chem |
| Year | 1996 |
| Volume | 271 |
| Pages | 18007-16 |
| Authors | Hermoso J, Pignol D, Kerfelec B, Crenon I, Chapus C, Fontecilla-Camps JC |
| Title |
Lipase activation by nonionic detergents. |
| Related PDB | 1eth |
| Related UniProtKB | P00591 |
| [24] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8939760 |
| Journal | Structure |
| Year | 1996 |
| Volume | 4 |
| Pages | 1363-74 |
| Authors | Withers-Martinez C, Carriere F, Verger R, Bourgeois D, Cambillau C |
| Title | A pancreatic lipase with a phospholipase A1 activity: crystal structure of a chimeric pancreatic lipase-related protein 2 from guinea pig. |
| Related PDB | |
| Related UniProtKB | |
| [25] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 8993339 |
| Journal | Biochemistry |
| Year | 1997 |
| Volume | 36 |
| Pages | 239-48 |
| Authors | Carriere F, Thirstrup K, Hjorth S, Ferrato F, Nielsen PF, Withers-Martinez C, Cambillau C, Boel E, Thim L, Verger R |
| Title | Pancreatic lipase structure-function relationships by domain exchange. |
| Related PDB | 1gpl |
| Related UniProtKB | |
| [26] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9312012 |
| Journal | EMBO J |
| Year | 1997 |
| Volume | 16 |
| Pages | 5531-6 |
| Authors | Hermoso J, Pignol D, Penel S, Roth M, Chapus C, Fontecilla-Camps JC |
| Title | Neutron crystallographic evidence of lipase-colipase complex activation by a micelle. |
| Related PDB | |
| Related UniProtKB | |
| [27] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9109604 |
| Journal | J Nutr |
| Year | 1997 |
| Volume | 127 |
| Pages | 549-57 |
| Authors | Lowe ME |
| Title | Molecular mechanisms of rat and human pancreatic triglyceride lipases. |
| Related PDB | |
| Related UniProtKB | |
| [28] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9502110 |
| Journal | Bioorg Med Chem |
| Year | 1998 |
| Volume | 6 |
| Pages | 109-18 |
| Authors | Parmar VS, Pati HN, Azim A, Kumar R, Himanshu, Bisht KS, Prasad AK, Errington W |
| Title | Lipase-catalysed selective deacetylation of phenolic/enolic acetoxy groups in peracetylated benzyl phenyl ketones. |
| Related PDB | |
| Related UniProtKB | |
| [29] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9720253 |
| Journal | Chem Phys Lipids |
| Year | 1998 |
| Volume | 93 |
| Pages | 103-14 |
| Authors | Bezzine S, Roussel A, de Caro J, Gastinel L, de Caro A, Carriere F, Leydier S, Verger R, Cambillau C |
| Title | An inactive pancreatic lipase-related protein is activated into a triglyceride-lipase by mutagenesis based on the 3-D structure. |
| Related PDB | |
| Related UniProtKB | |
| [30] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9720254 |
| Journal | Chem Phys Lipids |
| Year | 1998 |
| Volume | 93 |
| Pages | 123-9 |
| Authors | Pignol D, Hermoso J, Kerfelec B, Crenon I, Chapus C, Fontecilla-Camps JC |
| Title | The lipase/colipase complex is activated by a micelle: neutron crystallographic evidence. |
| Related PDB | |
| Related UniProtKB | |
| [31] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9837944 |
| Journal | J Biol Chem |
| Year | 1998 |
| Volume | 273 |
| Pages | 33604-9 |
| Authors | Ayvazian L, Crenon I, Hermoso J, Pignol D, Chapus C, Kerfelec B |
| Title | Ion pairing between lipase and colipase plays a critical role in catalysis. |
| Related PDB | |
| Related UniProtKB | |
| [32] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 17-468 |
| Medline ID | 99041983 |
| PubMed ID | 9822688 |
| Journal | J Biol Chem |
| Year | 1998 |
| Volume | 273 |
| Pages | 32121-8 |
| Authors | Roussel A, Yang Y, Ferrato F, Verger R, Cambillau C, Lowe M |
| Title | Structure and activity of rat pancreatic lipase-related protein 2. |
| Related PDB | 1bu8 |
| Related UniProtKB | P54318 |
| [33] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) |
| Medline ID | 98393022 |
| PubMed ID | 9726421 |
| Journal | Proteins |
| Year | 1998 |
| Volume | 32 |
| Pages | 523-31 |
| Authors | Roussel A, de Caro J, Bezzine S, Gastinel L, de Caro A, Carriere F, Leydier S, Verger R, Cambillau C |
| Title | Reactivation of the totally inactive pancreatic lipase RP1 by structure-predicted point mutations. |
| Related PDB | 1rp1 |
| Related UniProtKB | P06857 |
| [34] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10501005 |
| Journal | Biosci Biotechnol Biochem |
| Year | 1999 |
| Volume | 63 |
| Pages | 1467-70 |
| Authors | Tsuzuki W, Kitamura Y, Suzuki T, Mase T |
| Title | Effects of glucose on lipase activity. |
| Related PDB | |
| Related UniProtKB | |
| [35] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10669782 |
| Journal | Biochim Biophys Acta |
| Year | 2000 |
| Volume | 1476 |
| Pages | 165-72 |
| Authors | Miled N, De Caro A, De Caro J, Verger R |
| Title | A conformational transition between an open and closed form of human pancreatic lipase revealed by a monoclonal antibody. |
| Related PDB | |
| Related UniProtKB | |
| [36] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11099794 |
| Journal | Biochimie |
| Year | 2000 |
| Volume | 82 |
| Pages | 973-86 |
| Authors | Miled N, Canaan S, Dupuis L, Roussel A, Riviere M, Carriere F, de Caro A, Cambillau C, Verger R |
| Title | Digestive lipases: from three-dimensional structure to physiology. |
| Related PDB | |
| Related UniProtKB | |
| [37] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12369922 |
| Journal | Curr Protein Pept Sci |
| Year | 2000 |
| Volume | 1 |
| Pages | 91-103 |
| Authors | Chahinian H, Sias B, Carriere F |
| Title | The C-terminal domain of pancreatic lipase: functional and structural analogies with c2 domains. |
| Related PDB | |
| Related UniProtKB | |
| [38] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11377191 |
| Journal | Bioorg Med Chem |
| Year | 2001 |
| Volume | 9 |
| Pages | 1345-8 |
| Authors | Azim A, Sharma SK, Olsen CE, Parmar VS |
| Title | Lipase catalysed synthesis of optically enriched alpha-haloamides. |
| Related PDB | |
| Related UniProtKB | |
| [39] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11557352 |
| Journal | Bioorg Med Chem |
| Year | 2001 |
| Volume | 9 |
| Pages | 2643-52 |
| Authors | Kumar R, Azim A, Kumar V, Sharma SK, Prasad AK, Howarth OW, Olsen CE, Jain SC, Parmar VS |
| Title | Lipase-catalyzed chemo- and enantioselective acetylation of 2-alkyl/aryl-3-hydroxypropiophenones. |
| Related PDB | |
| Related UniProtKB | |
| [40] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11212097 |
| Journal | Bioorg Med Chem Lett |
| Year | 2001 |
| Volume | 11 |
| Pages | 305-7 |
| Authors | Basak A, Rudra KR, Bdour HM, Dasgupta J |
| Title | Active site geometry of porcine pancreatic lipase: an interesting switchover from Jones' to Seebach's model. |
| Related PDB | |
| Related UniProtKB | |
| [41] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11514151 |
| Journal | Bioorg Med Chem Lett |
| Year | 2001 |
| Volume | 11 |
| Pages | 2117-21 |
| Authors | Mukherjee S, Prasad AK, Parmar VS, Howarth OW |
| Title | Novel lipase-catalysed enantioselective deacetylation of (+/-)-5-acetoxy-3-(4-fluorophenyl)-2-phenylisoxazolidine. |
| Related PDB | |
| Related UniProtKB | |
| [42] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11457440 |
| Journal | Chem Phys Lipids |
| Year | 2001 |
| Volume | 111 |
| Pages | 105-10 |
| Authors | Ciuffreda P, Loseto A, Manzocchi A, Santaniello E |
| Title | Lipolytic activity of porcine pancreas lipase on fatty acid esters of dialkylglycerols: a structural basis for the design of new substrates for the assay of pancreatic lipases activity. |
| Related PDB | |
| Related UniProtKB | |
| [43] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11154696 |
| Journal | J Biol Chem |
| Year | 2001 |
| Volume | 276 |
| Pages | 14014-8 |
| Authors | Ayvazian L, Kerfelec B, Granon S, Foglizzo E, Crenon I, Dubois C, Chapus C |
| Title |
The lipase C-terminal domain. |
| Related PDB | |
| Related UniProtKB | |
| [44] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12022871 |
| Journal | Biochemistry |
| Year | 2002 |
| Volume | 41 |
| Pages | 6679-87 |
| Authors | Alam M, Vance DE, Lehner R |
| Title | Structure-function analysis of human triacylglycerol hydrolase by site-directed mutagenesis: identification of the catalytic triad and a glycosylation site. |
| Related PDB | |
| Related UniProtKB | |
| [45] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12427035 |
| Journal | Biochemistry |
| Year | 2002 |
| Volume | 41 |
| Pages | 13725-35 |
| Authors | Chahinian H, Bezzine S, Ferrato F, Ivanova MG, Perez B, Lowe ME, Carriere F |
| Title | The beta 5' loop of the pancreatic lipase C2-like domain plays a critical role in the lipase-lipid interactions. |
| Related PDB | |
| Related UniProtKB | |
| [46] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11836103 |
| Journal | Bioorg Med Chem |
| Year | 2002 |
| Volume | 10 |
| Pages | 947-51 |
| Authors | Prasad AK, Himanshu, Bhattacharya A, Olsen CE, Parmar VS |
| Title | Novel lipase-catalysed highly selective acetylation studies on D-arabino- and D-threo-polyhydroxyalkyltriazoles. |
| Related PDB | |
| Related UniProtKB | |
| [47] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12454260 |
| Journal | J Lipid Res |
| Year | 2002 |
| Volume | 43 |
| Pages | 2007-16 |
| Authors | Lowe ME |
| Title | The triglyceride lipases of the pancreas. |
| Related PDB | |
| Related UniProtKB | |
| Comments |
|---|
|
This enzyme forms a complex with a colipase protein, Although this enzyme binds a calcium ion, This enzyme has got a catalytic triad composed of serine/histidine/aspartate in the N-terminal domain. |
| Created | Updated |
|---|---|
| 2004-08-16 | 2012-10-22 |