DB code: M00041

CATH domain 2.60.60.20 : Lipoxygenase-1
4.10.375.10 : Lipoxygenase-1; domain 2
4.10.372.10 : Lipoxygenase-1; domain 3
3.10.450.60 : Nuclear Transport Factor 2; Chain
1.20.245.10 : Lipoxygenase-1; domain 5 Catalytic domain
E.C. 1.13.11.12
CSA 1lnh
M-CSA 1lnh
MACiE

CATH domain Related DB codes (homologues)
2.60.60.20 : Lipoxygenase-1 T00253

Uniprot Enzyme Name
UniprotKB Protein name Synonyms RefSeq Pfam
P08170 Seed lipoxygenase-1
L-1
EC 1.13.11.12
NP_001236153.1 (Protein)
NM_001249224.1 (DNA/RNA sequence)
PF00305 (Lipoxygenase)
PF01477 (PLAT)
[Graphical View]
P09186 Seed lipoxygenase-3
L-3
EC 1.13.11.12
NP_001235383.1 (Protein)
NM_001248454.1 (DNA/RNA sequence)
PF00305 (Lipoxygenase)
PF01477 (PLAT)
[Graphical View]

KEGG enzyme name
lipoxygenase
lipoxidase
carotene oxidase
lipoperoxidase
fat oxidase
lipoxydase
lionoleate:O2 oxidoreductase

UniprotKB: Accession Number Entry name Activity Subunit Subcellular location Cofactor
P08170 LOX1_SOYBN Linoleate + O(2) = (9Z,11E)-(13S)-13- hydroperoxyoctadeca-9,11-dienoate. Monomer. Cytoplasm. Binds 1 iron ion per subunit. Iron is tightly bound (By similarity).
P09186 LOX3_SOYBN Linoleate + O(2) = (9Z,11E)-(13S)-13- hydroperoxyoctadeca-9,11-dienoate. Monomer. Cytoplasm. Binds 1 iron ion per subunit. Iron is tightly bound (By similarity).

KEGG Pathways
Map code Pathways E.C.
MAP00591 Linoleic acid metabolism
MAP00592 alpha-Linolenic acid metabolism

Compound table
Cofactors Substrates Products Intermediates
KEGG-id C00023 C01595 C00007 C04717
E.C.
Compound Iron Linoleate O2 (9Z,11E)-(13S)-13-Hydroperoxyoctadeca-9,11-dienoate
Type heavy metal fatty acid others carbohydrate,fatty acid,lipid
ChEBI 18248
 82664
 18248
 82664
 		17351
 17351
 		15379
 26689
 27140
 15379
 26689
 27140
 		15655
 15655
PubChem 23925
 23925
 		5280450
 5280450
 		977
 977
 		5280720
 5280720
1f8nA01 Unbound Unbound Unbound Unbound
1fgmA01 Unbound Unbound Unbound Unbound
1fgoA01 Unbound Unbound Unbound Unbound
1fgqA01 Unbound Unbound Unbound Unbound
1fgrA01 Unbound Unbound Unbound Unbound
1fgtA01 Unbound Unbound Unbound Unbound
1hu9A01 Unbound Unbound Unbound Unbound
1ik3A01 Unbound Unbound Unbound Unbound
1jnqA01 Unbound Unbound Unbound Unbound
1lnhA01 Unbound Unbound Unbound Unbound
1n8qA01 Unbound Unbound Unbound Unbound
1no3A01 Unbound Unbound Unbound Unbound
1ygeA01 Unbound Unbound Unbound Unbound
2sblB01 Unbound Unbound Unbound Unbound
1f8nA02 Unbound Unbound Unbound Unbound
1fgmA02 Unbound Unbound Unbound Unbound
1fgoA02 Unbound Unbound Unbound Unbound
1fgqA02 Unbound Unbound Unbound Unbound
1fgrA02 Unbound Unbound Unbound Unbound
1fgtA02 Unbound Unbound Unbound Unbound
1hu9A02 Unbound Unbound Unbound Unbound
1ik3A02 Unbound Unbound Unbound Unbound
1jnqA02 Unbound Unbound Unbound Unbound
1lnhA02 Unbound Unbound Unbound Unbound
1n8qA02 Unbound Unbound Unbound Unbound
1no3A02 Unbound Unbound Unbound Unbound
1ygeA02 Unbound Unbound Unbound Unbound
2sblB02 Unbound Unbound Unbound Unbound
1f8nA03 Unbound Unbound Unbound Unbound
1fgmA03 Unbound Unbound Unbound Unbound
1fgoA03 Unbound Unbound Unbound Unbound
1fgqA03 Unbound Unbound Unbound Unbound
1fgrA03 Unbound Unbound Unbound Unbound
1fgtA03 Unbound Unbound Unbound Unbound
1hu9A03 Unbound Unbound Unbound Unbound
1ik3A03 Unbound Unbound Unbound Unbound
1jnqA03 Unbound Unbound Unbound Unbound
1lnhA03 Unbound Unbound Unbound Unbound
1n8qA03 Unbound Unbound Unbound Unbound
1no3A03 Unbound Unbound Unbound Unbound
1ygeA03 Unbound Unbound Unbound Unbound
2sblB03 Unbound Unbound Unbound Unbound
1f8nA04 Unbound Unbound Unbound Unbound
1fgmA04 Unbound Unbound Unbound Unbound
1fgoA04 Unbound Unbound Unbound Unbound
1fgqA04 Unbound Unbound Unbound Unbound
1fgrA04 Unbound Unbound Unbound Unbound
1fgtA04 Unbound Unbound Unbound Unbound
1hu9A04 Unbound Unbound Unbound Unbound
1ik3A04 Unbound Unbound Unbound Unbound
1jnqA04 Unbound Unbound Unbound Unbound
1lnhA04 Unbound Unbound Unbound Unbound
1n8qA04 Unbound Unbound Unbound Unbound
1no3A04 Unbound Unbound Unbound Unbound
1ygeA04 Unbound Unbound Unbound Unbound
2sblB04 Unbound Unbound Unbound Unbound
1f8nA05 Bound:FE2 Unbound Unbound Unbound
1fgmA05 Bound:_FE Unbound Unbound Unbound
1fgoA05 Bound:_FE Unbound Unbound Unbound
1fgqA05 Bound:_FE Unbound Unbound Unbound
1fgrA05 Bound:_FE Unbound Unbound Unbound
1fgtA05 Bound:_FE Unbound Unbound Unbound
1hu9A05 Bound:_FE Unbound Unbound Analogue:4HM
1ik3A05 Bound:_FE Unbound Unbound Bound:13S
1jnqA05 Bound:FE2 Unbound Unbound Analogue:EGT
1lnhA05 Bound:FE2 Unbound Unbound Unbound
1n8qA05 Bound:FE2 Unbound Unbound Analogue:DHB
1no3A05 Bound:_FE Unbound Unbound Analogue:4NC
1ygeA05 Bound:_FE Unbound Unbound Unbound
2sblB05 Bound:_FE Unbound Unbound Unbound

Reference for Active-site residues
resource references E.C.
literature [13], [48], [54]

Active-site residues
PDB Catalytic residues Cofactor-binding residues Modified residues Main-chain involved in catalysis Comment
1f8nA01
1fgmA01
1fgoA01
1fgqA01
1fgrA01
1fgtA01
1hu9A01
1ik3A01
1jnqA01
1lnhA01
1n8qA01
1no3A01
1ygeA01
2sblB01
1f8nA02
1fgmA02
1fgoA02
1fgqA02
1fgrA02
1fgtA02
1hu9A02
1ik3A02
1jnqA02
1lnhA02
1n8qA02
1no3A02
1ygeA02
2sblB02
1f8nA03
1fgmA03
1fgoA03
1fgqA03
1fgrA03
1fgtA03
1hu9A03
1ik3A03
1jnqA03
1lnhA03
1n8qA03
1no3A03
1ygeA03
2sblB03
1f8nA04
1fgmA04
1fgoA04
1fgqA04
1fgrA04
1fgtA04
1hu9A04
1ik3A04
1jnqA04
1lnhA04
1n8qA04
1no3A04
1ygeA04
2sblB04
1f8nA05 ASN 694 HIS 499;HIS 504;HIS 690;ASN 694;ILE 839(Iron binding)
1fgmA05 HIS 499;HIS 504;HIS 690;;ILE 839(Iron binding) mutant N694H
1fgoA05 ASN 694 HIS 499;HIS 504;HIS 690;ASN 694;ILE 839(Iron binding) mutant Q495A
1fgqA05 ASN 694 HIS 499;HIS 504;HIS 690;ASN 694;ILE 839(Iron binding) mutant Q495E
1fgrA05 ASN 694 HIS 499;HIS 504;HIS 690;ASN 694;ILE 839(Iron binding) mutant Q697E
1fgtA05 ASN 694 HIS 499;HIS 504;HIS 690;ASN 694;ILE 839(Iron binding) mutant Q697N
1hu9A05 ASN 713 HIS 518;HIS 523;HIS 709;ASN 713;ILE 857(Iron binding)
1ik3A05 ASN 713 HIS 518;HIS 523;HIS 709;ASN 713;ILE 857(Iron binding)
1jnqA05 ASN 713 HIS 518;HIS 523;HIS 709;ASN 713;ILE 857(Iron binding)
1lnhA05 ASN 713 HIS 518;HIS 523;HIS 709;ASN 713;ILE 857(Iron binding)
1n8qA05 ASN 713 HIS 518;HIS 523;HIS 709;ASN 713;ILE 857(Iron binding)
1no3A05 ASN 713 HIS 518;HIS 523;HIS 709;ASN 713;ILE 857(Iron binding)
1ygeA05 ASN 694 HIS 499;HIS 504;HIS 690;ASN 694;ILE 839(Iron binding)
2sblB05 ASN 694 HIS 499;HIS 504;HIS 690;ASN 694;ILE 839(Iron binding)

References for Catalytic Mechanism
References Sections No. of steps in catalysis
[2]
Fig.4, p.619-621
[9]
Fig.1, p.748
[11]
p.1486
[13]
p.15021-15022
[14]
Fig.1, p.15033
[15]
p.3978-3979
[20]
p.452-455
[21]
p.12890-12891
[22]
p.10699-10700
[24]
p.137-138
[27]
Scheme 1, p.635-636
[28]
Fig.3, Fig.11, p.806
[30]
Scheme 1, p.41-42
[35]
Scheme 1, Scheme 2, p.12225-12226
[42]
p.7515-7516
[45]
Scheme 1, p.10818-10819
[47]
Scheme 1
[52]
Fig.1, p.5774
[53]
Fig.11, p.2008-2013

References
[1]
Resource
Comments
Medline ID
PubMed ID 6784730
Journal Biochem Biophys Res Commun
Year 1981
Volume 98
Pages 922-9
Authors Funk MO, Kim SH, Alteneder AW
Title Factors affecting the initial rate of lipoxygenase catalysis.
Related PDB
Related UniProtKB
[2]
Resource
Comments
Medline ID
PubMed ID 3026385
Journal Biochem Biophys Res Commun
Year 1986
Volume 141
Pages 614-21
Authors Connor HD, Fischer V, Mason RP
Title A search for oxygen-centered free radicals in the lipoxygenase/linoleic acid system.
Related PDB
Related UniProtKB
[3]
Resource
Comments
Medline ID
PubMed ID 3126736
Journal Biochem Biophys Res Commun
Year 1988
Volume 151
Pages 339-46
Authors Mansuy D, Cucurou C, Biatry B, Battioni JP
Title Soybean lipoxygenase-catalyzed oxidations by linoleic acid hydroperoxide: different reducing substrates and dehydrogenation of phenidone and BW 755C.
Related PDB
Related UniProtKB
[4]
Resource
Comments
Medline ID
PubMed ID 2537058
Journal Arch Biochem Biophys
Year 1989
Volume 269
Pages 208-18
Authors Draheim JE, Carroll RT, McNemar TB, Dunham WR, Sands RH, Funk MO Jr
Title Lipoxygenase isoenzymes: a spectroscopic and structural characterization of soybean seed enzymes.
Related PDB
Related UniProtKB
[5]
Resource
Comments
Medline ID
PubMed ID 2115880
Journal J Biol Chem
Year 1990
Volume 265
Pages 12771-3
Authors Boyington JC, Gaffney BJ, Amzel LM
Title Crystallization and preliminary x-ray analysis of soybean lipoxygenase-1, a non-heme iron-containing dioxygenase.
Related PDB
Related UniProtKB
[6]
Resource
Comments
Medline ID
PubMed ID 2113534
Journal J Biol Chem
Year 1990
Volume 265
Pages 11352-4
Authors Steczko J, Muchmore CR, Smith JL, Axelrod B
Title Crystallization and preliminary X-ray investigation of lipoxygenase 1 from soybeans.
Related PDB
Related UniProtKB
[7]
Resource
Comments
Medline ID
PubMed ID 2313694
Journal J Mol Biol
Year 1990
Volume 211
Pages 685-7
Authors Stallings WC, Kroa BA, Carroll RT, Metzger AL, Funk MO
Title Crystallization and preliminary X-ray characterization of a soybean seed lipoxygenase.
Related PDB
Related UniProtKB
[8]
Resource
Comments
Medline ID
PubMed ID 1324720
Journal Biochemistry
Year 1992
Volume 31
Pages 7700-6
Authors Ramachandran S, Carroll RT, Dunham WR, Funk MO Jr
Title Limited proteolysis and active-site labeling studies of soybean lipoxygenase.
Related PDB
Related UniProtKB
[9]
Resource
Comments
Medline ID
PubMed ID 8224502
Journal Biochem Soc Trans
Year 1993
Volume 21
Pages 744-8
Authors Boyington JC, Gaffney BJ, Amzel LM
Title Structure of soybean lipoxygenase-I.
Related PDB
Related UniProtKB
[10]
Resource
Comments ACTIVE SITE, AND IRON LIGANDS
Medline ID 93298753
PubMed ID 8518276
Journal Biochemistry
Year 1993
Volume 32
Pages 6320-3
Authors Minor W, Steczko J, Bolin JT, Otwinowski Z, Axelrod B
Title Crystallographic determination of the active site iron and its ligands in soybean lipoxygenase L-1.
Related PDB
Related UniProtKB P08170
[11]
Resource
Comments
Medline ID
PubMed ID 8347579
Journal Biochemistry
Year 1993
Volume 32
Pages 7686-91
Authors Schilstra MJ, Veldink GA, Vliegenthart JF
Title Kinetic analysis of the induction period in lipoxygenase catalysis.
Related PDB
Related UniProtKB
[12]
Resource
Comments X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS)
Medline ID 93276267
PubMed ID 8502991
Journal Science
Year 1993
Volume 260
Pages 1482-6
Authors Boyington JC, Gaffney BJ, Amzel LM
Title The three-dimensional structure of an arachidonic acid 15-lipoxygenase.
Related PDB 2sbl
Related UniProtKB P08170
[13]
Resource
Comments
Medline ID
PubMed ID 7999759
Journal Biochemistry
Year 1994
Volume 33
Pages 15017-22
Authors Kramer JA, Johnson KR, Dunham WR, Sands RH, Funk MO Jr
Title Position 713 is critical for catalysis but not iron binding in soybean lipoxygenase 3.
Related PDB
Related UniProtKB
[14]
Resource
Comments
Medline ID
PubMed ID 7999760
Journal Biochemistry
Year 1994
Volume 33
Pages 15023-35
Authors Scarrow RC, Trimitsis MG, Buck CP, Grove GN, Cowling RA, Nelson MJ
Title X-ray spectroscopy of the iron site in soybean lipoxygenase-1: changes in coordination upon oxidation or addition of methanol.
Related PDB
Related UniProtKB
[15]
Resource
Comments
Medline ID
PubMed ID 8142401
Journal Biochemistry
Year 1994
Volume 33
Pages 3974-9
Authors Schilstra MJ, Veldink GA, Vliegenthart JF
Title The dioxygenation rate in lipoxygenase catalysis is determined by the amount of iron (III) lipoxygenase in solution.
Related PDB
Related UniProtKB
[16]
Resource
Comments
Medline ID
PubMed ID 7578097
Journal Biochemistry
Year 1995
Volume 34
Pages 14868-73
Authors Ramachandran S, Richards-Sucheck TJ, Skrzypczak-Jankun E, Wheelock MJ, Funk MO Jr
Title Catalysis sensitive conformational changes in soybean lipoxygenase revealed by limited proteolysis and monoclonal antibody experiments.
Related PDB
Related UniProtKB
[17]
Resource
Comments
Medline ID
PubMed ID 7628469
Journal Eur J Biochem
Year 1995
Volume 231
Pages 186-91
Authors van der Heijdt LM, Schilstra MJ, Feiters MC, Nolting HF, Hermes C, Veldink GA, Vliegenthart JF
Title Changes in the iron coordination sphere of Fe(II) lipoxygenase-1 from soybeans upon binding of linoleate or oleate.
Related PDB
Related UniProtKB
[18]
Resource
Comments
Medline ID
PubMed ID 7549886
Journal Protein Sci
Year 1995
Volume 4
Pages 1233-5
Authors Steczko J, Minor W, Stojanoff V, Axelrod B
Title Crystallization and preliminary X-ray investigation of lipoxygenase-3 from soybeans.
Related PDB
Related UniProtKB
[19]
Resource
Comments
Medline ID
PubMed ID 7878664
Journal Toxicol Appl Pharmacol
Year 1995
Volume 131
Pages 1-12
Authors Yu WK, Wells PG
Title Evidence for lipoxygenase-catalyzed bioactivation of phenytoin to a teratogenic reactive intermediate: in vitro studies using linoleic acid-dependent soybean lipoxygenase, and in vivo studies using pregnant CD-1 mice.
Related PDB
Related UniProtKB
[20]
Resource
Comments
Medline ID
PubMed ID 8800477
Journal Annu Rev Biophys Biomol Struct
Year 1996
Volume 25
Pages 431-59
Authors Gaffney BJ
Title Lipoxygenases: structural principles and spectroscopy.
Related PDB
Related UniProtKB
[21]
Resource
Comments
Medline ID
PubMed ID 8841132
Journal Biochemistry
Year 1996
Volume 35
Pages 12882-92
Authors Glickman MH, Klinman JP
Title Lipoxygenase reaction mechanism: demonstration that hydrogen abstraction from substrate precedes dioxygen binding during catalytic turnover.
Related PDB
Related UniProtKB
[22]
Resource
Comments X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS)
Medline ID 96346062
PubMed ID 8718858
Journal Biochemistry
Year 1996
Volume 35
Pages 10687-701
Authors Minor W, Steczko J, Stec B, Otwinowski Z, Bolin JT, Walter R, Axelrod B
Title Crystal structure of soybean lipoxygenase L-1 at 1.4 A resolution.
Related PDB 1yge
Related UniProtKB P08170
[23]
Resource
Comments
Medline ID
PubMed ID 8778775
Journal Proteins
Year 1996
Volume 24
Pages 275-91
Authors Prigge ST, Boyington JC, Gaffney BJ, Amzel LM
Title Structure conservation in lipoxygenases: structural analysis of soybean lipoxygenase-1 and modeling of human lipoxygenases.
Related PDB
Related UniProtKB
[24]
Resource
Comments
Medline ID
PubMed ID 9547548
Journal Adv Exp Med Biol
Year 1997
Volume 400A
Pages 133-8
Authors Boyington JC, Gaffney BJ, Amzel LM
Title The three-dimensional structure of soybean lipoxygenase-1: an arachidonic acid 15-lipoxygenase.
Related PDB
Related UniProtKB
[25]
Resource
Comments
Medline ID
PubMed ID 9561173
Journal Adv Exp Med Biol
Year 1997
Volume 433
Pages 371-4
Authors Suzuki H, Yamamoto S
Title Molecular and catalytic properties of mammalian lipoxygenases compared with soybean lipoxygenase-1.
Related PDB
Related UniProtKB
[26]
Resource
Comments
Medline ID
PubMed ID 9295158
Journal Biochim Biophys Acta
Year 1997
Volume 1347
Pages 140-50
Authors Lopez-Nicolas JM, Bru R, Garcia-Carmona F
Title Kinetic characteristics of the enzymatic conversion in presence of cyclodextrins: study of the oxidation of polyunsaturated fatty acids by lipoxygenase.
Related PDB
Related UniProtKB
[27]
Resource
Comments
Medline ID
PubMed ID 9479444
Journal Biochimie
Year 1997
Volume 79
Pages 629-36
Authors Prigge ST, Boyington JC, Faig M, Doctor KS, Gaffney BJ, Amzel LM
Title Structure and mechanism of lipoxygenases.
Related PDB
Related UniProtKB
[28]
Resource
Comments
Medline ID
PubMed ID 9384534
Journal Chem Biol
Year 1997
Volume 4
Pages 795-808
Authors Solomon EI, Zhou J, Neese F, Pavel EG
Title New insights from spectroscopy into the structure/function relationships of lipoxygenases.
Related PDB
Related UniProtKB
[29]
Resource
Comments X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS)
Medline ID 97440646
PubMed ID 9294864
Journal Proteins
Year 1997
Volume 29
Pages 15-31
Authors Skrzypczak-Jankun E, Amzel LM, Kroa BA, Funk MO Jr
Title Structure of soybean lipoxygenase L3 and a comparison with its L1 isoenzyme.
Related PDB 1lnh
Related UniProtKB P09186
[30]
Resource
Comments
Medline ID
PubMed ID 9639559
Journal Biochem J
Year 1998
Volume 333
Pages 33-43
Authors Hughes RK, Wu Z, Robinson DS, Hardy D, West SI, Fairhurst SA, Casey R
Title Characterization of authentic recombinant pea-seed lipoxygenases with distinct properties and reaction mechanisms.
Related PDB
Related UniProtKB
[31]
Resource
Comments X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS)
Medline ID
PubMed ID 9922163
Journal Biochemistry
Year 1998
Volume 37
Pages 17952-7
Authors Pham C, Jankun J, Skrzypczak-Jankun E, Flowers RA 2nd, Funk MO Jr
Title Structural and thermochemical characterization of lipoxygenase-catechol complexes.
Related PDB
Related UniProtKB P09186
[32]
Resource
Comments
Medline ID
PubMed ID 9858760
Journal Biochim Biophys Acta
Year 1998
Volume 1388
Pages 325-36
Authors Wu Y, Wang ZX
Title Comparison of conformational changes and inactivation of soybean lipoxygenase-1 during urea denaturation.
Related PDB
Related UniProtKB
[33]
Resource
Comments
Medline ID
PubMed ID 10558895
Journal Biochem Biophys Res Commun
Year 1999
Volume 265
Pages 489-93
Authors Garcia-Barrado JA, Gata JL, Santano E, Solis JI, Pinto MC, Macias P
Title The use of fluorescein 5'-isothiocyanate for studies of structural and molecular mechanisms of soybean lipoxygenase.
Related PDB
Related UniProtKB
[34]
Resource
Comments
Medline ID
PubMed ID 10529238
Journal Biochemistry
Year 1999
Volume 38
Pages 13920-7
Authors Began G, Sudharshan E, Appu Rao AG
Title Change in the positional specificity of lipoxygenase 1 due to insertion of fatty acids into phosphatidylcholine deoxycholate mixed micelles.
Related PDB
Related UniProtKB
[35]
Resource
Comments
Medline ID 99119225
PubMed ID 10493789
Journal Biochemistry
Year 1999
Volume 38
Pages 12218-28
Authors Rickert KW, Klinman JP
Title Nature of hydrogen transfer in soybean lipoxygenase 1: separation of primary and secondary isotope effects.
Related PDB
Related UniProtKB
[36]
Resource
Comments
Medline ID
PubMed ID 10585402
Journal J Biol Chem
Year 1999
Volume 274
Pages 35351-8
Authors Sudharshan E, Rao AG
Title Involvement of cysteine residues and domain interactions in the reversible unfolding of lipoxygenase-1.
Related PDB
Related UniProtKB
[37]
Resource
Comments
Medline ID
PubMed ID 10769137
Journal Biochemistry
Year 2000
Volume 39
Pages 4801-7
Authors Mogul R, Johansen E, Holman TR
Title Oleyl sulfate reveals allosteric inhibition of soybean lipoxygenase-1 and human 15-lipoxygenase.
Related PDB
Related UniProtKB
[38]
Resource
Comments
Medline ID
PubMed ID 10672019
Journal Eur J Biochem
Year 2000
Volume 267
Pages 1100-9
Authors May C, Hohne M, Gnau P, Schwennesen K, Kindl H
Title The N-terminal beta-barrel structure of lipid body lipoxygenase mediates its binding to liposomes and lipid bodies.
Related PDB
Related UniProtKB
[39]
Resource
Comments
Medline ID
PubMed ID 11029517
Journal Int J Mol Med
Year 2000
Volume 6
Pages 521-6
Authors Skrzypczak-Jankun E, McCabe NP, Selman SH, Jankun J
Title Curcumin inhibits lipoxygenase by binding to its central cavity: theoretical and X-ray evidence.
Related PDB
Related UniProtKB
[40]
Resource
Comments
Medline ID
PubMed ID 11396936
Journal Biochem Biophys Res Commun
Year 2001
Volume 284
Pages 563-7
Authors Kariapper MS, Dunham WR, Funk MO Jr
Title Iron extraction from soybean lipoxygenase 3 and reconstitution of catalytic activity from the apoenzyme.
Related PDB
Related UniProtKB
[41]
Resource
Comments
Medline ID
PubMed ID 11741336
Journal Biochem Biophys Res Commun
Year 2001
Volume 289
Pages 1295-300
Authors Malvezzi-Campeggi F, Rosato N, Finazzi-Agro A, Maccarrone M
Title Effect of denaturants on the structural properties of soybean lipoxygenase-1.
Related PDB
Related UniProtKB
[42]
Resource
Comments X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS).
Medline ID
PubMed ID 11412104
Journal Biochemistry
Year 2001
Volume 40
Pages 7509-17
Authors Tomchick DR, Phan P, Cymborowski M, Minor W, Holman TR
Title Structural and functional characterization of second-coordination sphere mutants of soybean lipoxygenase-1.
Related PDB 1f8n 1fgm 1fgo 1fgq 1fgr 1fgt
Related UniProtKB P08170
[43]
Resource
Comments
Medline ID
PubMed ID 11407646
Journal Biophys Chem
Year 2001
Volume 90
Pages 303-6
Authors Maccarrone M, Bari M, Battista N, Finazzi-Agro A
Title The catalytic efficiency of soybean lipoxygenase-1 is enhanced at low gravity.
Related PDB
Related UniProtKB
[44]
Resource
Comments
Medline ID
PubMed ID 11321679
Journal Biophys Chem
Year 2001
Volume 90
Pages 97-101
Authors Maccarrone M, Bari M, Battista N, Finazzi-Agro A
Title The catalytic efficiency of soybean lipoxygenase-1 is enhanced at low gravity.
Related PDB
Related UniProtKB
[45]
Resource
Comments X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
Medline ID
PubMed ID 11686682
Journal J Am Chem Soc
Year 2001
Volume 123
Pages 10814-20
Authors Skrzypczak-Jankun E, Bross RA, Carroll RT, Dunham WR, Funk MO Jr
Title Three-dimensional structure of a purple lipoxygenase.
Related PDB 1ik3
Related UniProtKB P09186
[46]
Resource
Comments
Medline ID
PubMed ID 12105957
Journal J Agric Food Chem
Year 2002
Volume 50
Pages 4270-4
Authors Noordermeer MA, Van Der Goot W, Van Kooij AJ, Veldsink JW, Veldink GA, Vliegenthart JF
Title Development of a biocatalytic process for the production of c6-aldehydes from vegetable oils by soybean lipoxygenase and recombinant hydroperoxide lyase.
Related PDB
Related UniProtKB
[47]
Resource
Comments
Medline ID
PubMed ID 11942823
Journal J Am Chem Soc
Year 2002
Volume 124
Pages 3865-74
Authors Knapp MJ, Rickert K, Klinman JP
Title Temperature-dependent isotope effects in soybean lipoxygenase-1: correlating hydrogen tunneling with protein dynamics.
Related PDB
Related UniProtKB
[48]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 12964012
Journal Int J Mol Med
Year 2003
Volume 12
Pages 415-20
Authors Skrzypczak-Jankun E, Zhou K, Jankun J
Title Inhibition of lipoxygenase by (-)-epigallocatechin gallate: X-ray analysis at 2.1 A reveals degradation of EGCG and shows soybean LOX-3 complex with EGC instead.
Related PDB 1jnq
Related UniProtKB
[49]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 12792803
Journal Int J Mol Med
Year 2003
Volume 12
Pages 17-24
Authors Skrzypczak-Jankun E, Zhou K, McCabe NP, Selman SH, Jankun J
Title Structure of curcumin in complex with lipoxygenase and its significance in cancer.
Related PDB 1hu9
Related UniProtKB
[50]
Resource
Comments
Medline ID
PubMed ID 12626522
Journal J Biol Chem
Year 2003
Volume 278
Pages 18281-8
Authors Di Venere A, Salucci ML, van Zadelhoff G, Veldink G, Mei G, Rosato N, Finazzi-Agro A, Maccarrone M
Title Structure-to-function relationship of mini-lipoxygenase, a 60-kDa fragment of soybean lipoxygenase-1 with lower stability but higher enzymatic activity.
Related PDB
Related UniProtKB
[51]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 14993710
Journal Acta Crystallogr D Biol Crystallogr
Year 2004
Volume 60
Pages 613-5
Authors Skrzypczak-Jankun E, Borbulevych OY, Jankun J
Title Soybean lipoxygenase-3 in complex with 4-nitrocatechol.
Related PDB 1no3
Related UniProtKB
[52]
Resource
Comments
Medline ID
PubMed ID 15125669
Journal J Am Chem Soc
Year 2004
Volume 126
Pages 5763-75
Authors Hatcher E, Soudackov AV, Hammes-Schiffer S
Title Proton-coupled electron transfer in soybean lipoxygenase.
Related PDB
Related UniProtKB
[53]
Resource
Comments
Medline ID
PubMed ID 14971933
Journal J Am Chem Soc
Year 2004
Volume 126
Pages 2006-15
Authors Vahedi-Faridi A, Brault PA, Shah P, Kim YW, Dunham WR, Funk MO Jr
Title Interaction between non-heme iron of lipoxygenases and cumene hydroperoxide: basis for enzyme activation, inactivation, and inhibition.
Related PDB
Related UniProtKB
[54]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 14705020
Journal Proteins
Year 2004
Volume 54
Pages 13-9
Authors Borbulevych OY, Jankun J, Selman SH, Skrzypczak-Jankun E
Title Lipoxygenase interactions with natural flavonoid, quercetin, reveal a complex with protocatechuic acid in its X-ray structure at 2.1 A resolution.
Related PDB 1n8q
Related UniProtKB

Comments

Created Updated
2004-11-22 2009-02-26