DB code: S00724
| RLCP classification | 1.12.30000.27 : Hydrolysis | |
|---|---|---|
| CATH domain | 3.40.50.1820 : Rossmann fold | Catalytic domain |
| E.C. | 3.1.1.74 | |
| CSA | 1agy | |
| M-CSA | 1agy | |
| MACiE | ||
| CATH domain | Related DB codes (homologues) |
|---|---|
| 3.40.50.1820 : Rossmann fold | S00544 S00344 S00517 S00525 S00526 S00720 S00723 S00725 S00919 S00057 S00374 S00345 S00347 S00348 S00346 S00350 S00352 S00353 S00355 S00356 S00358 D00189 D00210 D00539 T00253 |
| Uniprot Enzyme Name | UniprotKB | Protein name | Synonyms | Pfam | RefSeq |
|---|---|---|---|---|
| P00590 |
Cutinase 1
|
EC
3.1.1.74
Cutin hydrolase 1 |
PF01083
(Cutinase)
[Graphical View] |
|
| P11373 |
Cutinase 1
|
EC
3.1.1.74
Cutin hydrolase 1 |
PF01083
(Cutinase)
[Graphical View] |
|
| P52956 |
Cutinase 1
|
EC
3.1.1.74
Cutin hydrolase 1 L1 |
PF01083
(Cutinase)
[Graphical View] |
XP_001817153.1
(Protein)
XM_001817101.2 (DNA/RNA sequence) |
| KEGG enzyme name |
|---|
|
Cutinase
|
| UniprotKB: Accession Number | Entry name | Activity | Subunit | Subcellular location | Cofactor |
|---|---|---|---|---|---|
| P00590 | CUTI1_FUSSO | Cutin + H2O = cutin monomers. | Secreted. | ||
| P11373 | CUTI1_COLGL | Cutin + H2O = cutin monomers. | Secreted. | ||
| P52956 | CUTI1_ASPOR | Cutin + H2O = cutin monomers. | Secreted. |
| KEGG Pathways | Map code | Pathways | E.C. |
|---|
| Compound table | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Substrates | Products | Intermediates | |||||||||||||||
| KEGG-id | L00043 | C00001 | L00068 | L00067 | L00044 | L00069 | L00070 | L00071 | L00072 | I00123 | I00085 | I00086 | |||||
| E.C. | |||||||||||||||||
| Compound | Cutin | H2O | C16 cutin monomer (Palmitic acid) | Hydroxyl-C16 cutin monomer (16-hydroxypalmitic acid) | Dihydroxyl-C16 cutin monomer (dihydroxypalmitic acid) | C18 cutin monomer (Oleic acid) | Hydroxyl-C18 cutin monomer (18-hydroxyoleic acid) | Hydroxyl-epoxyl-C18 cutin monomer (9,10-epoxy-18-hydroxystearic acid) | Trihydroxyl-C18 cutin monomer (9,10,18-trihydroxystearic acid) | Peptidyl-Ser-tetrahedral intermediate (with previous carboxylic-ester) | Acyl-enzyme (Peptidyl-Ser-acyl group) | Peptidyl-Ser-tetrahedral-intermediate | |||||
| Type | carbohydrate,fatty acid | H2O | carbohydrate,fatty acid | carbohydrate,fatty acid | carbohydrate,fatty acid | carbohydrate,fatty acid | carbohydrate,fatty acid | carbohydrate,fatty acid | carbohydrate,fatty acid | ||||||||
| ChEBI |
15377 15377 |
15756 15756 |
55328 55328 |
16196 16196 |
79312 79312 |
||||||||||||
| PubChem |
22247451 962 22247451 962 |
985 985 |
10466 10466 |
322588 322588 |
445639 445639 |
5312773 5312773 |
9818312 9818312 |
5282938 5282938 |
|||||||||
| 1agyA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1cexA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1cuaA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1cubA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1cucA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1cudA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1cudB00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1cudC00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1cueA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1cufA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1cugA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1cuhA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1cuiA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1cujA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1cusA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1cuuA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1cuvA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1cuwA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1cuwB00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1cuxA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1cuyA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1cuzA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ffaA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ffbA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ffcA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ffdA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ffeA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1oxmA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:TC4 | Unbound | Unbound | |
| 1oxmB00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:TC4 | Unbound | Unbound | |
| 1xzaA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1xzbA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1xzcA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1xzdA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1xzeA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1xzfA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1xzgA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1xzhA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1xziA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1xzjA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1xzkA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:DFP | Unbound | Unbound | |
| 1xzkB00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:DFP | Unbound | Unbound | |
| 1xzlA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:HEE | Unbound | Unbound | |
| 1xzmA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:DPE | Unbound | Unbound | |
| 2cutA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:DEP | Unbound | Unbound | |
| 3ef3A00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:NXC | Unbound | Unbound | |
| 3esaA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:NXC | Unbound | Unbound | |
| 3esaB00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:NXC | Unbound | Unbound | |
| 3esbA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:NXC | Unbound | Unbound | |
| 3escA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:SXC | Unbound | Unbound | |
| 3esdA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:SXC | Unbound | Unbound | |
| 3dcnA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3dd5A00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:DEP | Unbound | Unbound | |
| 3dd5B00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:DEP | Unbound | Unbound | |
| 3dd5C00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:DEP | Unbound | Unbound | |
| 3dd5D00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:DEP | Unbound | Unbound | |
| 3dd5E00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:DEP | Unbound | Unbound | |
| 3dd5F00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:DEP | Unbound | Unbound | |
| 3dd5G00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:DEP | Unbound | Unbound | |
| 3dd5H00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:DEP | Unbound | Unbound | |
| 3deaA00 |
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Analogue:HZH | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3deaB00 |
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Analogue:HZH | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 3gbsA00 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| Reference for Active-site residues | ||
|---|---|---|
| resource | references | E.C. |
| literature [2], [3], [4], [11], [12], [13], [16], [19] | ||
| Active-site residues | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Catalytic residues | Cofactor-binding residues | Modified residues | Main-chain involved in catalysis | Comment | |||||
| 1agyA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | |||
| 1cexA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A | ||
| 1cuaA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A, N172K | ||
| 1cubA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A, N172K, R196D | ||
| 1cucA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A, N172K, R196D | ||
| 1cudA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A, N172K, R196D | ||
| 1cudB00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A, N172K, R196D | ||
| 1cudC00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A, N172K, R196D | ||
| 1cueA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A, Q121L | ||
| 1cufA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A, R156I | ||
| 1cugA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A, R17E, N172K | ||
| 1cuhA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A, R196E | ||
| 1cuiA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A, S120A | ||
| 1cujA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A, S120C | ||
| 1cusA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A | ||
| 1cuuA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A, A199C | ||
| 1cuvA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A, A85F | ||
| 1cuwA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A, G82A, A85F, V184I, A185L, L189F | ||
| 1cuwB00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A, G82A, A85F, V184I, A185L, L189F | ||
| 1cuxA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A, I114Y | ||
| 1cuyA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A, I189F | ||
| 1cuzA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A, I81G, I182G | ||
| 1ffaA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant N84A | ||
| 1ffbA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant N84D | ||
| 1ffcA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant N84L | ||
| 1ffdA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant N84W | ||
| 1ffeA00 |
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;SER 120;ASP 175;HIS 188 | ;GLN 121 | mutant S42A | ||
| 1oxmA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A | ||
| 1oxmB00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A | ||
| 1xzaA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A, S129C | ||
| 1xzbA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A, S129C | ||
| 1xzcA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A, S129C | ||
| 1xzdA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A, S213C | ||
| 1xzeA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A, S92C | ||
| 1xzfA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A, T144C | ||
| 1xzgA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A, T45A | ||
| 1xzhA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A, T80P | ||
| 1xziA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A, Y119H | ||
| 1xzjA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A, Y38F | ||
| 1xzkA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A | ||
| 1xzkB00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A | ||
| 1xzlA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A | ||
| 1xzmA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A | ||
| 2cutA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A | ||
| 3ef3A00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A, N172K | ||
| 3esaA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A, N172K | ||
| 3esaB00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A, N172K | ||
| 3esbA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A, N172K | ||
| 3escA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A, N172K | ||
| 3esdA00 |
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SER 42;SER 120;ASP 175;HIS 188 | SER 42;GLN 121 | mutant R32A, N172K | ||
| 3dcnA00 |
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SER 57;SER 136;ASP 191;HIS 204 | SER 57;GLN 137 | |||
| 3dd5A00 |
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SER 57;SER 136;ASP 191;HIS 204 | SER 57;GLN 137 | |||
| 3dd5B00 |
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SER 57;SER 136;ASP 191;HIS 204 | SER 57;GLN 137 | |||
| 3dd5C00 |
|
|
|
|
|
SER 57;SER 136;ASP 191;HIS 204 | SER 57;GLN 137 | |||
| 3dd5D00 |
|
|
|
|
|
SER 57;SER 136;ASP 191;HIS 204 | SER 57;GLN 137 | |||
| 3dd5E00 |
|
|
|
|
|
SER 57;SER 136;ASP 191;HIS 204 | SER 57;GLN 137 | |||
| 3dd5F00 |
|
|
|
|
|
SER 57;SER 136;ASP 191;HIS 204 | SER 57;GLN 137 | |||
| 3dd5G00 |
|
|
|
|
|
SER 57;SER 136;ASP 191;HIS 204 | SER 57;GLN 137 | |||
| 3dd5H00 |
|
|
|
|
|
SER 57;SER 136;ASP 191;HIS 204 | SER 57;GLN 137 | |||
| 3deaA00 |
|
|
|
|
|
SER 57;SER 136;ASP 191; | SER 57;GLN 137 | invisible 197-204 | ||
| 3deaB00 |
|
|
|
|
|
SER 57;SER 136;ASP 191; | SER 57;GLN 137 | invisible 201-204 | ||
| 3gbsA00 |
|
|
|
|
|
SER 48;SER 126;ASP 181;HIS 194 | SER 48;GLN 127 | |||
| References for Catalytic Mechanism | ||
|---|---|---|
| References | Sections | No. of steps in catalysis |
|
[2]
|
p.615-618 | |
|
[3]
|
p.83, p.86-88 | |
|
[4]
|
p.406-409 | |
|
[11]
|
p.186-188 | |
|
[12]
|
p.90-97 | |
|
[16]
|
Fig.1, p.1004-1005 | |
|
[19]
|
p.231-233 | |
| References | |
|---|---|
| [1] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 17779010 |
| Journal | Science |
| Year | 1980 |
| Volume | 208 |
| Pages | 990-1000 |
| Authors | Kolattukudy PE |
| Title | Biopolyester membranes of plants: cutin and suberin. |
| Related PDB | |
| Related UniProtKB | |
| [2] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS). |
| Medline ID | |
| PubMed ID | 1560844 |
| Journal | Nature |
| Year | 1992 |
| Volume | 356 |
| Pages | 615-8 |
| Authors | Martinez C, De Geus P, Lauwereys M, Matthyssens G, Cambillau C |
| Title | Fusarium solani cutinase is a lipolytic enzyme with a catalytic serine accessible to solvent. |
| Related PDB | 1cus |
| Related UniProtKB | P00590 |
| [3] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS). |
| Medline ID | |
| PubMed ID | 8286366 |
| Journal | Biochemistry |
| Year | 1994 |
| Volume | 33 |
| Pages | 83-9 |
| Authors | Martinez C, Nicolas A, van Tilbeurgh H, Egloff MP, Cudrey C, Verger R, Cambillau C |
| Title |
Cutinase, |
| Related PDB | 2cut |
| Related UniProtKB | P00590 |
| [4] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8555209 |
| Journal | Biochemistry |
| Year | 1996 |
| Volume | 35 |
| Pages | 398-410 |
| Authors | Nicolas A, Egmond M, Verrips CT, de Vlieg J, Longhi S, Cambillau C, Martinez C |
| Title | Contribution of cutinase serine 42 side chain to the stabilization of the oxyanion transition state. |
| Related PDB | 1ffa 1ffb 1ffc 1ffd 1ffe |
| Related UniProtKB | |
| [5] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8990497 |
| Journal | Proteins |
| Year | 1996 |
| Volume | 26 |
| Pages | 442-58 |
| Authors | Longhi S, Nicolas A, Creveld L, Egmond M, Verrips CT, de Vlieg J, Martinez C, Cambillau C |
| Title | Dynamics of Fusarium solani cutinase investigated through structural comparison among different crystal forms of its variants. |
| Related PDB | 1cua 1cub 1cuc 1cud 1cue 1cuf 1cug 1cuh 1cui 1cuj 1cuu 1cuv 1cuw 1cux 1cuy 1cuz 1xza 1xzd 1xze 1xzf 1xzg 1xzh 1xzi 1xzj 1xzk 1xzl 1xzm |
| Related UniProtKB | |
| [6] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (1.0 ANGSTROMS) OF 17-230. |
| Medline ID | |
| PubMed ID | 9175860 |
| Journal | J Mol Biol |
| Year | 1997 |
| Volume | 268 |
| Pages | 779-99 |
| Authors | Longhi S, Czjzek M, Lamzin V, Nicolas A, Cambillau C |
| Title | Atomic resolution (1.0 A) crystal structure of Fusarium solani cutinase: stereochemical analysis. |
| Related PDB | 1agy 1cex |
| Related UniProtKB | P00590 |
| [7] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9041628 |
| Journal | Protein Sci |
| Year | 1997 |
| Volume | 6 |
| Pages | 275-86 |
| Authors | Longhi S, Mannesse M, Verheij HM, De Haas GH, Egmond M, Knoops-Mouthuy E, Cambillau C |
| Title | Crystal structure of cutinase covalently inhibited by a triglyceride analogue. |
| Related PDB | 1oxm |
| Related UniProtKB | |
| [8] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS). |
| Medline ID | |
| PubMed ID | 9438866 |
| Journal | Structure |
| Year | 1997 |
| Volume | 5 |
| Pages | 1571-84 |
| Authors | Kim KK, Song HK, Shin DH, Hwang KY, Choe S, Yoo OJ, Suh SW |
| Title |
Crystal structure of carboxylesterase from Pseudomonas fluorescens, |
| Related PDB | 1auo 1aur |
| Related UniProtKB | Q53547 |
| [9] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | |
| Journal | Electron. J. Biotechnol |
| Year | 1998 |
| Volume | 1 |
| Pages | 160-173 |
| Authors | Cristina M. L. Carvalho, Maria Raquel Aires-Barros, Joaquim M. S. Cabral |
| Title |
Cutinase structure, |
| Related PDB | |
| Related UniProtKB | |
| [10] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9593202 |
| Journal | Proteins |
| Year | 1998 |
| Volume | 31 |
| Pages | 320-33 |
| Authors | Jelsch C, Longhi S, Cambillau C |
| Title | Packing forces in nine crystal forms of cutinase. |
| Related PDB | |
| Related UniProtKB | |
| [11] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10570246 |
| Journal | Biochim Biophys Acta |
| Year | 1999 |
| Volume | 1441 |
| Pages | 185-96 |
| Authors | Longhi S, Cambillau C |
| Title |
Structure-activity of cutinase, |
| Related PDB | |
| Related UniProtKB | |
| [12] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10388742 |
| Journal | Biophys J |
| Year | 1999 |
| Volume | 77 |
| Pages | 85-98 |
| Authors | Lau EY, Bruice TC |
| Title | Consequences of breaking the Asp-His hydrogen bond of the catalytic triad: effects on the structure and dynamics of the serine esterase cutinase. |
| Related PDB | |
| Related UniProtKB | |
| [13] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11099798 |
| Journal | Biochimie |
| Year | 2000 |
| Volume | 82 |
| Pages | 1015-21 |
| Authors | Egmond MR, de Vlieg J |
| Title | Fusarium solani pisi cutinase. |
| Related PDB | |
| Related UniProtKB | |
| [14] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11243887 |
| Journal | J Struct Biol |
| Year | 2000 |
| Volume | 132 |
| Pages | 180-90 |
| Authors | Hakulinen N, Tenkanen M, Rouvinen J |
| Title | Three-dimensional structure of the catalytic core of acetylxylan esterase from Trichoderma reesei: insights into the deacetylation mechanism. |
| Related PDB | |
| Related UniProtKB | |
| [15] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11080636 |
| Journal | Structure |
| Year | 2000 |
| Volume | 8 |
| Pages | 1137-46 |
| Authors | Devedjiev Y, Dauter Z, Kuznetsov SR, Jones TL, Derewenda ZS |
| Title | Crystal structure of the human acyl protein thioesterase I from a single X-ray data set to 1.5 A. |
| Related PDB | 1fj2 |
| Related UniProtKB | |
| [16] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 15923226 |
| Journal | Biophys J |
| Year | 2005 |
| Volume | 89 |
| Pages | 999-1008 |
| Authors | Micaelo NM, Teixeira VH, Baptista AM, Soares CM |
| Title | Water dependent properties of cutinase in nonaqueous solvents: a computational study of enantioselectivity. |
| Related PDB | |
| Related UniProtKB | |
| [17] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 19219875 |
| Journal | Chemistry |
| Year | 2009 |
| Volume | 15 |
| Pages | 4270-80 |
| Authors | Rutten L, Wieczorek B, Mannie JP, Kruithof CA, Dijkstra HP, Egmond MR, Lutz M, Klein Gebbink RJ, Gros P, van Koten G |
| Title | Solid-state structural characterization of cutinase-ECE-pincer-metal hybrids. |
| Related PDB | 3ef3 3esa 3esb 3esc 3esd |
| Related UniProtKB | |
| [18] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 19810726 |
| Journal | J Am Chem Soc |
| Year | 2009 |
| Volume | 131 |
| Pages | 15711-6 |
| Authors | Liu Z, Gosser Y, Baker PJ, Ravee Y, Lu Z, Alemu G, Li H, Butterfoss GL, Kong XP, Gross R, Montclare JK |
| Title | Structural and functional studies of Aspergillus oryzae cutinase: enhanced thermostability and hydrolytic activity of synthetic ester and polyester degradation. |
| Related PDB | 3gbs |
| Related UniProtKB | |
| [19] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 18983850 |
| Journal | J Mol Biol |
| Year | 2009 |
| Volume | 385 |
| Pages | 226-35 |
| Authors | Nyon MP, Rice DW, Berrisford JM, Hounslow AM, Moir AJ, Huang H, Nathan S, Mahadi NM, Bakar FD, Craven CJ |
| Title | Catalysis by Glomerella cingulata cutinase requires conformational cycling between the active and inactive states of its catalytic triad. |
| Related PDB | 3dcn 3dd5 3dea |
| Related UniProtKB | |
| Comments |
|---|
|
This enzyme belongs to the lipase family (subfamily of the serine hydrolase superfamily).
Cutin is a carbohydraate polymer, This enzyme has got a catalytic triad composed of serine/histidine/aspartate, |
| Created | Updated |
|---|---|
| 2010-01-25 | 2012-02-16 |