DB code: S00221
| CATH domain | 3.20.20.70 : TIM Barrel | Catalytic domain |
|---|---|---|
| E.C. | 4.1.1.23 | |
| CSA | 1dbt 1eix | |
| M-CSA | 1dbt 1eix | |
| MACiE | M0050 | |
| CATH domain | Related DB codes (homologues) |
|---|---|
| 3.20.20.70 : TIM Barrel | S00215 S00217 S00218 S00219 S00532 S00198 S00220 S00745 S00537 S00538 S00539 S00826 S00841 S00235 S00239 S00240 S00243 S00244 S00199 S00200 S00201 S00222 S00847 S00224 S00225 S00226 D00014 D00029 M00141 T00015 T00239 D00664 D00665 D00804 D00863 T00089 |
| Uniprot Enzyme Name | UniprotKB | Protein name | Synonyms | RefSeq | Pfam |
|---|---|---|---|---|
| O26232 |
Orotidine 5''-phosphate decarboxylase
|
EC
4.1.1.23
OMP decarboxylase OMPDCase OMPdecase |
NP_275272.1
(Protein)
NC_000916.1 (DNA/RNA sequence) |
PF00215
(OMPdecase)
[Graphical View] |
| P03962 |
Orotidine 5''-phosphate decarboxylase
|
EC
4.1.1.23
OMP decarboxylase OMPDCase OMPdecase Uridine 5''-monophosphate synthase UMP synthase |
NP_010893.3
(Protein)
NM_001178836.3 (DNA/RNA sequence) |
PF00215
(OMPdecase)
[Graphical View] |
| P25971 |
Orotidine 5''-phosphate decarboxylase
|
EC
4.1.1.23
OMP decarboxylase OMPDCase OMPdecase |
NP_389438.1
(Protein)
NC_000964.3 (DNA/RNA sequence) |
PF00215
(OMPdecase)
[Graphical View] |
| P08244 |
Orotidine 5''-phosphate decarboxylase
|
EC
4.1.1.23
OMP decarboxylase OMPDCase OMPdecase |
NP_415797.1
(Protein)
NC_000913.2 (DNA/RNA sequence) YP_489549.1 (Protein) NC_007779.1 (DNA/RNA sequence) |
PF00215
(OMPdecase)
[Graphical View] |
| KEGG enzyme name |
|---|
|
orotidine-5'-phosphate decarboxylase
orotidine-5'-monophosphate decarboxylase orotodylate decarboxylase orotidine phosphate decarboxylase OMP decarboxylase orotate monophosphate decarboxylase orotidine monophosphate decarboxylase orotidine phosphate decarboxylase OMP-DC orotate decarboxylase orotidine 5'-phosphate decarboxylase orotidylic decarboxylase orotidylic acid decarboxylase orotodylate decarboxylase ODCase orotic decarboxylase orotidine-5'-phosphate carboxy-lyase |
| UniprotKB: Accession Number | Entry name | Activity | Subunit | Subcellular location | Cofactor |
|---|---|---|---|---|---|
| O26232 | PYRF_METTH | Orotidine 5''-phosphate = UMP + CO(2). | Homodimer. | ||
| P03962 | PYRF_YEAST | Orotidine 5''-phosphate = UMP + CO(2). | |||
| P25971 | PYRF_BACSU | Orotidine 5''-phosphate = UMP + CO(2). | Homodimer. | ||
| P08244 | PYRF_ECOLI | Orotidine 5''-phosphate = UMP + CO(2). | Homodimer. |
| KEGG Pathways | Map code | Pathways | E.C. |
|---|---|---|
| MAP00240 | Pyrimidine metabolism |
| Compound table | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Substrates | Products | Intermediates | |||||||
| KEGG-id | C01103 | C00105 | C00011 | ||||||
| E.C. | |||||||||
| Compound | Orotidine 5'-phosphate | UMP | CO2 | literature | |||||
| Type | amide group,carbohydrate,nucleotide | amide group,nucleotide | others | [18] | |||||
| ChEBI |
15842 15842 |
16695 16695 |
16526 16526 |
||||||
| PubChem |
160617 160617 |
6030 6030 |
280 280 |
||||||
| 1dbtA |
|
|
|
|
|
Unbound | Bound:U5P | Unbound | Unbound |
| 1dbtB |
|
|
|
|
|
Unbound | Bound:U5P | Unbound | Unbound |
| 1dbtC |
|
|
|
|
|
Unbound | Bound:U5P | Unbound | Unbound |
| 1dqwA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound |
| 1dqwB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound |
| 1dqwC |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound |
| 1dqwD |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound |
| 1dqxA |
|
|
|
|
|
Unbound | Unbound | Unbound | Transition-state-analogue:BMP |
| 1dqxB |
|
|
|
|
|
Unbound | Unbound | Unbound | Transition-state-analogue:BMP |
| 1dqxC |
|
|
|
|
|
Unbound | Unbound | Unbound | Transition-state-analogue:BMP |
| 1dqxD |
|
|
|
|
|
Unbound | Unbound | Unbound | Transition-state-analogue:BMP |
| 1dv7A |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound |
| 1dvjA |
|
|
|
|
|
Unbound | Analogue:UP6 | Unbound | Unbound |
| 1dvjB |
|
|
|
|
|
Unbound | Analogue:UP6 | Unbound | Unbound |
| 1dvjC |
|
|
|
|
|
Unbound | Analogue:UP6 | Unbound | Unbound |
| 1dvjD |
|
|
|
|
|
Unbound | Analogue:UP6 | Unbound | Unbound |
| 1eixA |
|
|
|
|
|
Analogue:BMQ | Unbound | Unbound | Unbound |
| 1eixB |
|
|
|
|
|
Analogue:BMQ | Unbound | Unbound | Unbound |
| 1eixC |
|
|
|
|
|
Analogue:BMQ | Unbound | Unbound | Unbound |
| 1eixD |
|
|
|
|
|
Analogue:BMQ | Unbound | Unbound | Unbound |
| 1jjkA |
|
|
|
|
|
Unbound | Unbound | Unbound | Transition-state-analogue:BMP |
| 1jjkB |
|
|
|
|
|
Unbound | Unbound | Unbound | Transition-state-analogue:BMP |
| 1jjkC |
|
|
|
|
|
Unbound | Unbound | Unbound | Transition-state-analogue:BMP |
| 1jjkD |
|
|
|
|
|
Unbound | Unbound | Unbound | Transition-state-analogue:BMP |
| 1jjkE |
|
|
|
|
|
Unbound | Unbound | Unbound | Transition-state-analogue:BMP |
| 1jjkF |
|
|
|
|
|
Unbound | Unbound | Unbound | Transition-state-analogue:BMP |
| 1jjkG |
|
|
|
|
|
Unbound | Unbound | Unbound | Transition-state-analogue:BMP |
| 1jjkH |
|
|
|
|
|
Unbound | Unbound | Unbound | Transition-state-analogue:BMP |
| 1jjkI |
|
|
|
|
|
Unbound | Unbound | Unbound | Transition-state-analogue:BMP |
| 1jjkJ |
|
|
|
|
|
Unbound | Unbound | Unbound | Transition-state-analogue:BMP |
| 1jjkK |
|
|
|
|
|
Unbound | Unbound | Unbound | Transition-state-analogue:BMP |
| 1jjkL |
|
|
|
|
|
Unbound | Unbound | Unbound | Transition-state-analogue:BMP |
| 1jjkM |
|
|
|
|
|
Unbound | Unbound | Unbound | Transition-state-analogue:BMP |
| 1jjkN |
|
|
|
|
|
Unbound | Unbound | Unbound | Transition-state-analogue:BMP |
| 1jjkO |
|
|
|
|
|
Unbound | Unbound | Unbound | Transition-state-analogue:BMP |
| 1jjkP |
|
|
|
|
|
Unbound | Unbound | Unbound | Transition-state-analogue:BMP |
| 1l2uA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound |
| 1l2uB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound |
| Reference for Active-site residues | ||
|---|---|---|
| resource | references | E.C. |
| Swiss-prot;O26232, P03962, P25971 | ||
| Active-site residues | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Catalytic residues | Cofactor-binding residues | Modified residues | Main-chain involved in catalysis | Comment | |||||
| 1dbtA |
|
|
|
|
|
LYS 62 | ||||
| 1dbtB |
|
|
|
|
|
LYS 62 | ||||
| 1dbtC |
|
|
|
|
|
LYS 62 | ||||
| 1dqwA |
|
|
|
|
|
LYS 93 | ||||
| 1dqwB |
|
|
|
|
|
LYS 93 | ||||
| 1dqwC |
|
|
|
|
|
LYS 93 | ||||
| 1dqwD |
|
|
|
|
|
LYS 93 | ||||
| 1dqxA |
|
|
|
|
|
LYS 93 | ||||
| 1dqxB |
|
|
|
|
|
LYS 93 | ||||
| 1dqxC |
|
|
|
|
|
LYS 93 | ||||
| 1dqxD |
|
|
|
|
|
LYS 93 | ||||
| 1dv7A |
|
|
|
|
|
LYS 72 | ||||
| 1dvjA |
|
|
|
|
|
LYS 72 | ||||
| 1dvjB |
|
|
|
|
|
LYS 72 | ||||
| 1dvjC |
|
|
|
|
|
LYS 72 | ||||
| 1dvjD |
|
|
|
|
|
LYS 72 | ||||
| 1eixA |
|
|
|
|
|
LYS 73 | ||||
| 1eixB |
|
|
|
|
|
LYS 73 | ||||
| 1eixC |
|
|
|
|
|
LYS 73 | ||||
| 1eixD |
|
|
|
|
|
LYS 73 | ||||
| 1jjkA |
|
|
|
|
|
LYS 73 | ||||
| 1jjkB |
|
|
|
|
|
LYS 73 | ||||
| 1jjkC |
|
|
|
|
|
LYS 73 | ||||
| 1jjkD |
|
|
|
|
|
LYS 73 | ||||
| 1jjkE |
|
|
|
|
|
LYS 73 | ||||
| 1jjkF |
|
|
|
|
|
LYS 73 | ||||
| 1jjkG |
|
|
|
|
|
LYS 73 | ||||
| 1jjkH |
|
|
|
|
|
LYS 73 | ||||
| 1jjkI |
|
|
|
|
|
LYS 73 | ||||
| 1jjkJ |
|
|
|
|
|
LYS 73 | ||||
| 1jjkK |
|
|
|
|
|
LYS 73 | ||||
| 1jjkL |
|
|
|
|
|
LYS 73 | ||||
| 1jjkM |
|
|
|
|
|
LYS 73 | ||||
| 1jjkN |
|
|
|
|
|
LYS 73 | ||||
| 1jjkO |
|
|
|
|
|
LYS 73 | ||||
| 1jjkP |
|
|
|
|
|
LYS 73 | ||||
| 1l2uA |
|
|
|
|
|
LYS 73 | ||||
| 1l2uB |
|
|
|
|
|
LYS 73 | ||||
| References for Catalytic Mechanism | ||
|---|---|---|
| References | Sections | No. of steps in catalysis |
|
[6]
|
p.12167-12168 | |
|
[7]
|
p.336-341 | |
|
[9]
|
||
|
[11]
|
Fig.6, Fig.7, p.4222-4224 | 2 |
|
[12]
|
p.8116-8117 | |
|
[14]
|
Fig.3, Fig.4, Fig.5, p.4572-4574 | |
|
[15]
|
p.14731-14733 | |
|
[16]
|
Fig.2, p.714-716 | |
|
[17]
|
Scheme 1, Fig.7, p.2009-2010 | 2 |
|
[18]
|
Fig.7, p.2014-2016 | 3 |
|
[19]
|
Scheme II, p.2020-2022 | 3 |
|
[20]
|
||
|
[22]
|
Fig.1, Fig.2, p.104-105 | |
|
[23]
|
Scheme 3, Scheme 4, p.114-118 | |
|
[24]
|
Fig.12, p.12846-12848 | |
|
[26]
|
Fig.8, p.863-874 | |
|
[32]
|
Fig. 1 | p.268 |
| References | |
|---|---|
| [1] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 6894094 |
| Journal | Biochemistry |
| Year | 1980 |
| Volume | 19 |
| Pages | 6068-74 |
| Authors | Traut TW, Payne RC |
| Title | Dependence of the catalytic activities on the aggregation and conformation states of uridine 5'-phosphate synthase. |
| Related PDB | |
| Related UniProtKB | |
| [2] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 6894093 |
| Journal | Biochemistry |
| Year | 1980 |
| Volume | 19 |
| Pages | 6062-8 |
| Authors | Traut TW, Payne RC, Jones ME |
| Title |
Dependence of the aggregation and conformation states of uridine 5'-phosphate synthase on pyrimidine nucleotides. |
| Related PDB | |
| Related UniProtKB | |
| [3] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 2334689 |
| Journal | Biochemistry |
| Year | 1990 |
| Volume | 29 |
| Pages | 3198-202 |
| Authors | Acheson SA, Bell JB, Jones ME, Wolfenden R |
| Title | Orotidine-5'-monophosphate decarboxylase catalysis: kinetic isotope effects and the state of hybridization of a bound transition-state analogue. |
| Related PDB | |
| Related UniProtKB | |
| [4] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 2008434 |
| Journal | Proteins |
| Year | 1991 |
| Volume | 9 |
| Pages | 143-51 |
| Authors | Bell JB, Jones ME, Carter CW Jr |
| Title | Crystallization of yeast orotidine 5'-monophosphate decarboxylase complexed with 1-(5'-phospho-beta-D-ribofuranosyl) barbituric acid. |
| Related PDB | |
| Related UniProtKB | |
| [5] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1457411 |
| Journal | Biochemistry |
| Year | 1992 |
| Volume | 31 |
| Pages | 12155-61 |
| Authors | Shostak K, Jones ME |
| Title | Orotidylate decarboxylase: insights into the catalytic mechanism from substrate specificity studies. |
| Related PDB | |
| Related UniProtKB | |
| [6] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1457412 |
| Journal | Biochemistry |
| Year | 1992 |
| Volume | 31 |
| Pages | 12162-8 |
| Authors | Smiley JA, Jones ME |
| Title | A unique catalytic and inhibitor-binding role for Lys93 of yeast orotidylate decarboxylase. |
| Related PDB | |
| Related UniProtKB | |
| [7] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1499340 |
| Journal | Curr Top Cell Regul |
| Year | 1992 |
| Volume | 33 |
| Pages | 331-42 |
| Authors | Jones ME |
| Title | Orotidylate decarboxylase of yeast and man. |
| Related PDB | |
| Related UniProtKB | |
| [8] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8631878 |
| Journal | J Biol Chem |
| Year | 1996 |
| Volume | 271 |
| Pages | 10704-8 |
| Authors | Yablonski MJ, Pasek DA, Han BD, Jones ME, Traut TW |
| Title |
Intrinsic activity and stability of bifunctional human UMP synthase and its two separate catalytic domains, |
| Related PDB | |
| Related UniProtKB | |
| [9] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9139656 |
| Journal | Science |
| Year | 1997 |
| Volume | 276 |
| Pages | 942-5 |
| Authors | Lee JK, Houk KN |
| Title | A proficient enzyme revisited: the predicted mechanism for orotidine monophosphate decarboxylase. |
| Related PDB | |
| Related UniProtKB | |
| [10] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10334928 |
| Journal | Biochem Biophys Res Commun |
| Year | 1999 |
| Volume | 259 |
| Pages | 133-5 |
| Authors | Cui W, DeWitt JG, Miller SM, Wu W |
| Title | No metal cofactor in orotidine 5'-monophosphate decarboxylase. |
| Related PDB | |
| Related UniProtKB | |
| [11] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 10757968 |
| Journal | Biochemistry |
| Year | 2000 |
| Volume | 39 |
| Pages | 4217-24 |
| Authors | Harris P, Navarro Poulsen JC, Jensen KF, Larsen S |
| Title | Structural basis for the catalytic mechanism of a proficient enzyme: orotidine 5'-monophosphate decarboxylase. |
| Related PDB | 1eix |
| Related UniProtKB | |
| [12] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10889016 |
| Journal | Biochemistry |
| Year | 2000 |
| Volume | 39 |
| Pages | 8113-8 |
| Authors | Miller BG, Snider MJ, Short SA, Wolfenden R |
| Title | Contribution of enzyme-phosphoribosyl contacts to catalysis by orotidine 5'-phosphate decarboxylase. |
| Related PDB | |
| Related UniProtKB | |
| [13] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10995247 |
| Journal | Biochemistry |
| Year | 2000 |
| Volume | 39 |
| Pages | 11788-800 |
| Authors | Porter DJ, Short SA |
| Title | Yeast orotidine-5'-phosphate decarboxylase: steady-state and pre-steady-state analysis of the kinetic mechanism of substrate decarboxylation. |
| Related PDB | |
| Related UniProtKB | |
| [14] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10769111 |
| Journal | Biochemistry |
| Year | 2000 |
| Volume | 39 |
| Pages | 4569-74 |
| Authors | Rishavy MA, Cleland WW |
| Title | Determination of the mechanism of orotidine 5'-monophosphate decarboxylase by isotope effects. |
| Related PDB | |
| Related UniProtKB | |
| [15] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11101287 |
| Journal | Biochemistry |
| Year | 2000 |
| Volume | 39 |
| Pages | 14728-38 |
| Authors | Warshel A, Strajbl M, Villa J, Florian J |
| Title | Remarkable rate enhancement of orotidine 5'-monophosphate decarboxylase is due to transition-state stabilization rather than to ground-state destabilization. |
| Related PDB | |
| Related UniProtKB | |
| [16] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11114509 |
| Journal | Curr Opin Struct Biol |
| Year | 2000 |
| Volume | 10 |
| Pages | 711-8 |
| Authors | Begley TP, Appleby TC, Ealick SE |
| Title | The structural basis for the remarkable catalytic proficiency of orotidine 5'-monophosphate decarboxylase. |
| Related PDB | |
| Related UniProtKB | |
| [17] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 10681442 |
| Journal | Proc Natl Acad Sci U S A |
| Year | 2000 |
| Volume | 97 |
| Pages | 2005-10 |
| Authors | Appleby TC, Kinsland C, Begley TP, Ealick SE |
| Title | The crystal structure and mechanism of orotidine 5'-monophosphate decarboxylase. |
| Related PDB | 1dbt |
| Related UniProtKB | |
| [18] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS). |
| Medline ID | 20160896 |
| PubMed ID | 10681417 |
| Journal | Proc Natl Acad Sci U S A |
| Year | 2000 |
| Volume | 97 |
| Pages | 2011-6 |
| Authors | Miller BG, Hassell AM, Wolfenden R, Milburn MV, Short SA |
| Title | Anatomy of a proficient enzyme: the structure of orotidine 5'-monophosphate decarboxylase in the presence and absence of a potential transition state analog. |
| Related PDB | 1dqw 1dqx |
| Related UniProtKB | P03962 |
| [19] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS). |
| Medline ID | 20160897 |
| PubMed ID | 10681441 |
| Journal | Proc Natl Acad Sci U S A |
| Year | 2000 |
| Volume | 97 |
| Pages | 2017-22 |
| Authors | Wu N, Mo Y, Gao J, Pai EF |
| Title | Electrostatic stress in catalysis: structure and mechanism of the enzyme orotidine monophosphate decarboxylase. |
| Related PDB | 1dv7 1dvj |
| Related UniProtKB | O26232 |
| [20] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11526316 |
| Journal | Acta Crystallogr D Biol Crystallogr |
| Year | 2001 |
| Volume | 57 |
| Pages | 1251-9 |
| Authors | Poulsen JC, Harris P, Jensen KF, Larsen S |
| Title | Selenomethionine substitution of orotidine-5'-monophosphate decarboxylase causes a change in crystal contacts and space group. |
| Related PDB | 1jjk |
| Related UniProtKB | |
| [21] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11371183 |
| Journal | Biochemistry |
| Year | 2001 |
| Volume | 40 |
| Pages | 6227-32 |
| Authors | Miller BG, Butterfoss GL, Short SA, Wolfenden R |
| Title | Role of enzyme-ribofuranosyl contacts in the ground state and transition state for orotidine 5'-phosphate decarboxylase: a role for substrate destabilization? |
| Related PDB | |
| Related UniProtKB | |
| [22] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11300698 |
| Journal | Bioorg Chem |
| Year | 2001 |
| Volume | 29 |
| Pages | 96-106 |
| Authors | Smiley JA, Hay KM, Levison BS |
| Title | A reexamination of the substrate utilization of 2-thioorotidine-5'-monophosphate by yeast orotidine-5'-monophosphate decarboxylase. |
| Related PDB | |
| Related UniProtKB | |
| [23] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11828434 |
| Journal | Chembiochem |
| Year | 2001 |
| Volume | 2 |
| Pages | 113-8 |
| Authors | Houk KN, Lee JK, Tantillo DJ, Bahmanyar S, Hietbrink BN |
| Title | Crystal structures of orotidine monophosphate decarboxylase: does the structure reveal the mechanism of nature's most proficient enzyme? |
| Related PDB | |
| Related UniProtKB | |
| [24] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11749542 |
| Journal | J Am Chem Soc |
| Year | 2001 |
| Volume | 123 |
| Pages | 12837-48 |
| Authors | Lee TS, Chong LT, Chodera JD, Kollman PA |
| Title | An alternative explanation for the catalytic proficiency of orotidine 5'-phosphate decarboxylase. |
| Related PDB | |
| Related UniProtKB | |
| [25] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11278904 |
| Journal | J Biol Chem |
| Year | 2001 |
| Volume | 276 |
| Pages | 15174-6 |
| Authors | Miller BG, Snider MJ, Wolfenden R, Short SA |
| Title | Dissecting a charged network at the active site of orotidine-5'-phosphate decarboxylase. |
| Related PDB | |
| Related UniProtKB | |
| [26] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12045113 |
| Journal | Annu Rev Biochem |
| Year | 2002 |
| Volume | 71 |
| Pages | 847-85 |
| Authors | Miller BG, Wolfenden R |
| Title | Catalytic proficiency: the unusual case of OMP decarboxylase. |
| Related PDB | |
| Related UniProtKB | |
| [27] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11900527 |
| Journal | Biochemistry |
| Year | 2002 |
| Volume | 41 |
| Pages | 3861-9 |
| Authors | Wise E, Yew WS, Babbitt PC, Gerlt JA, Rayment I |
| Title | Homologous (beta/alpha)8-barrel enzymes that catalyze unrelated reactions: orotidine 5'-monophosphate decarboxylase and 3-keto-L-gulonate 6-phosphate decarboxylase. |
| Related PDB | |
| Related UniProtKB | |
| [28] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11900543 |
| Journal | Biochemistry |
| Year | 2002 |
| Volume | 41 |
| Pages | 4002-11 |
| Authors | Wu N, Gillon W, Pai EF |
| Title | Mapping the active site-ligand interactions of orotidine 5'-monophosphate decarboxylase by crystallography. |
| Related PDB | |
| Related UniProtKB | |
| [29] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12430437 |
| Journal | Chem Commun (Camb) |
| Year | 2002 |
| Volume | (20) |
| Pages | 2354-5 |
| Authors | Kurinovich MA, Phillips LM, Sharma S, Lee JK |
| Title | The gas phase proton affinity of uracil: measuring multiple basic sites and implications for the enzyme mechanism of orotidine 5'-monophosphate decarboxylase. |
| Related PDB | |
| Related UniProtKB | |
| [30] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12011084 |
| Journal | J Biol Chem |
| Year | 2002 |
| Volume | 277 |
| Pages | 28080-7 |
| Authors | Wu N, Pai EF |
| Title | Crystal structures of inhibitor complexes reveal an alternate binding mode in orotidine-5'-monophosphate decarboxylase. |
| Related PDB | |
| Related UniProtKB | |
| [31] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12054799 |
| Journal | J Mol Biol |
| Year | 2002 |
| Volume | 318 |
| Pages | 1019-29 |
| Authors | Harris P, Poulsen JC, Jensen KF, Larsen S |
| Title | Substrate binding induces domain movements in orotidine 5'-monophosphate decarboxylase. |
| Related PDB | 1l2u |
| Related UniProtKB | |
| [32] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12667491 |
| Journal | Arch Biochem Biophys |
| Year | 2003 |
| Volume | 412 |
| Pages | 267-71 |
| Authors | Smiley JA, DelFraino BJ, Simpson BA |
| Title | Hydrogen isotope tracing in the reaction of orotidine-5'-monophosphate decarboxylase. |
| Related PDB | |
| Related UniProtKB | |
| Comments |
|---|
| Created | Updated |
|---|---|
| 2004-04-04 | 2009-02-26 |