DB code: D00173
| CATH domain | -.-.-.- : | |
|---|---|---|
| 2.120.10.10 : Neuraminidase | Catalytic domain | |
| E.C. | 3.2.1.18 | |
| CSA | 1a4g 7nn9 | |
| M-CSA | 1a4g 7nn9 | |
| MACiE | ||
| CATH domain | Related DB codes (homologues) |
|---|---|
| 2.120.10.10 : Neuraminidase | M00310 T00064 T00065 T00208 |
| Uniprot Enzyme Name | UniprotKB | Protein name | Synonyms | CAZy | Pfam |
|---|---|---|---|---|
| P03472 |
Neuraminidase
|
EC
3.2.1.18
|
GH34
(Glycoside Hydrolase Family 34)
|
PF00064
(Neur)
[Graphical View] |
| P05803 |
Neuraminidase
|
EC
3.2.1.18
|
GH34
(Glycoside Hydrolase Family 34)
|
PF00064
(Neur)
[Graphical View] |
| P27907 |
Neuraminidase
|
EC
3.2.1.18
|
GH34
(Glycoside Hydrolase Family 34)
|
PF00064
(Neur)
[Graphical View] |
| KEGG enzyme name |
|---|
|
exo-alpha-sialidase
neuraminidase sialidase alpha-neuraminidase acetylneuraminidase |
| UniprotKB: Accession Number | Entry name | Activity | Subunit | Subcellular location | Cofactor |
|---|---|---|---|---|---|
| P03472 | NRAM_I75A5 | Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. | Homotetramer (By similarity). | Virion membrane (By similarity). Apical cell membrane, Single-pass type II membrane protein (By similarity). Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane (By similarity). | Binds 1 calcium ion (By similarity). |
| P05803 | NRAM_I84A1 | Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. | Homotetramer (By similarity). | Virion membrane (By similarity). Apical cell membrane, Single-pass type II membrane protein (By similarity). Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane (By similarity). | Binds 1 calcium ion. |
| P27907 | NRAM_INBBE | Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. | Homotetramer. | Virion membrane (By similarity). Apical cell membrane, Single-pass type II membrane protein (By similarity). Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. In the virion, forms a mushroom-shaped spike on the surface of the membrane (By similarity). |
| KEGG Pathways | Map code | Pathways | E.C. |
|---|---|---|
| MAP00511 | N-Glycan degradation | |
| MAP00600 | Sphingolipid metabolism | |
| MAP01032 | Glycan structures - degradation |
| Compound table | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Substrates | Products | Intermediates | ||||||||||||||||||
| KEGG-id | C00001 | C06128 | C04730 | C04884 | C04927 | C06139 | C06140 | C00270 | C02686 | C01290 | C06135 | C04911 | C06140 | C06141 | ||||||
| E.C. | ||||||||||||||||||||
| Compound | H2O | N-Acetylneuraminyl-galactosylceramide | (N-Acetylneuraminyl)-D-galactosyl-D-glucosylceramide | N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide | N-Acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide | Neu5Ac-alpha2->8Neu5Ac-alpha2->3Gal-beta1->3GalNAc-beta1->4(Neu5Ac-alpha2->8Neu5Ac-alpha2->3)Gal-beta1->4Glc-beta1->1'Cer | Neu5Ac-alpha2->3Gal-beta1->3GalNAc-beta1->4(Neu5Ac-alpha2->8Neu5Ac-alpha2->3)Gal-beta1->4Glc-beta1->1'Cer | N-Acetylneuraminate | Galactosylceramide | beta-D-Galactosyl-1,4-beta-D-glucosylceramide | GalNAc-beta1->4Gal-beta1->4Glc-beta1->1'Cer | D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide | Neu5Ac-alpha2->3Gal-beta1->3GalNAc-beta1->4(Neu5Ac-alpha2->8Neu5Ac-alpha2->3)Gal-beta1->4Glc-beta1->1'Cer | Gal-beta1->3GalNAc-beta1->4(Neu5Ac-alpha2->8Neu5Ac-alpha2->3)Gal-beta1->4Glc-beta1->1'Cer | ||||||
| Type | H2O | amide group,carbohydrate,carboxyl group,lipid | amide group,carbohydrate,carboxyl group,lipid,polysaccharide | amide group,carbohydrate,carboxyl group,lipid,polysaccharide | amide group,carbohydrate,carboxyl group,lipid,polysaccharide | amide group,carbohydrate,carboxyl group,lipid,polysaccharide | amide group,carbohydrate,carboxyl group,lipid,polysaccharide | amide group,carbohydrate,carboxyl group | amide group,carbohydrate,lipid | amide group,carbohydrate,lipid,polysaccharide | amide group,carbohydrate,lipid,polysaccharide | amide group,carbohydrate,carboxyl group,lipid,polysaccharide | amide group,carbohydrate,carboxyl group,lipid | amide group,carbohydrate,carboxyl group,lipid,polysaccharide | ||||||
| ChEBI |
15377 15377 |
17012 17012 |
||||||||||||||||||
| PubChem |
22247451 962 22247451 962 |
439197 439197 |
||||||||||||||||||
| 1a14N |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1f8bA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:DAN | |
| 1f8cA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:4AM | |
| 1f8dA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:9AM | |
| 1f8eA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:49A | |
| 1inyA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Analogue:EQP | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1l7fA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Analogue:BCZ | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1l7gA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Analogue:BCZ | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1l7hA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Analogue:BCZ | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1mweA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Bound:SIA_1 | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ncaN |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ncbN |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1nccN |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1nmcA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1nmcN |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1nnaA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1nnbA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:DAN | |
| 1nncA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Analogue:ZMR | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2qwaA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2qwbA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Bound:SIA_800 | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2qwcA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:DAN | |
| 2qwdA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:4AM | |
| 2qweA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Analogue:GNA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2qwfA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:G20 | |
| 2qwgA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Analogue:G28 | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2qwhA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:G39 | |
| 2qwiA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:G20 | |
| 2qwjA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Analogue:G28 | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 2qwkA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:G39 | |
| 3nn9A |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 4nn9A |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 5nn9A |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 6nn9A |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 7nn9A |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1ncdN |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1nmaN |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1nmbN |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1a4gA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:ZMR | |
| 1a4gB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:ZMR | |
| 1a4qA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:DPC | |
| 1a4qB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:DPC | |
| 1nsbA |
|
|
|
|
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1nsbB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1nscA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Bound:SIA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1nscB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Bound:SIA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1nsdA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:DAN | |
| 1nsdB |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:DAN | |
| Reference for Active-site residues | ||
|---|---|---|
| resource | references | E.C. |
| Literature [9] | ||
| Active-site residues | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Catalytic residues | Cofactor-binding residues | Modified residues | Main-chain involved in catalysis | Comment | |||||
| 1a14N |
|
|
|
|
|
ASP 151;GLU 277;TYR 406 | ||||
| 1f8bA |
|
|
|
|
|
ASP 151;GLU 277;TYR 406 | ||||
| 1f8cA |
|
|
|
|
|
ASP 151;GLU 277;TYR 406 | ||||
| 1f8dA |
|
|
|
|
|
ASP 151;GLU 277;TYR 406 | ||||
| 1f8eA |
|
|
|
|
|
ASP 151;GLU 277;TYR 406 | ||||
| 1inyA |
|
|
|
|
|
ASP 151;GLU 278;TYR 405 | ||||
| 1l7fA |
|
|
|
|
|
ASP 151;GLU 277;TYR 406 | ||||
| 1l7gA |
|
|
|
|
|
ASP 151;GLU 277;TYR 406 | mutant E119G | |||
| 1l7hA |
|
|
|
|
|
ASP 151;GLU 277;TYR 406 | mutant R292K | |||
| 1mweA |
|
|
|
|
|
ASP 151;GLU 277;TYR 406 | ||||
| 1ncaN |
|
|
|
|
|
ASP 151;GLU 277;TYR 406 | ||||
| 1ncbN |
|
|
|
|
|
ASP 151;GLU 277;TYR 406 | mutant N329D | |||
| 1nccN |
|
|
|
|
|
ASP 151;GLU 277;TYR 406 | mutant I368R | |||
| 1nmcA |
|
|
|
|
|
ASP 151;GLU 277;TYR 406 | ||||
| 1nmcN |
|
|
|
|
|
ASP 151;GLU 277;TYR 406 | ||||
| 1nnaA |
|
|
|
|
|
ASP 152;GLU 279;TYR 406 | ||||
| 1nnbA |
|
|
|
|
|
ASP 152;GLU 279;TYR 406 | ||||
| 1nncA |
|
|
|
|
|
ASP 151;GLU 277;TYR 406 | ||||
| 2qwaA |
|
|
|
|
|
ASP 151;GLU 277;TYR 406 | mutant R292K | |||
| 2qwbA |
|
|
|
|
|
ASP 151;GLU 277;TYR 406 | mutant R292K | |||
| 2qwcA |
|
|
|
|
|
ASP 151;GLU 277;TYR 406 | mutant R292K | |||
| 2qwdA |
|
|
|
|
|
ASP 151;GLU 277;TYR 406 | mutant R292K | |||
| 2qweA |
|
|
|
|
|
ASP 151;GLU 277;TYR 406 | mutant R292K | |||
| 2qwfA |
|
|
|
|
|
ASP 151;GLU 277;TYR 406 | mutant R292K | |||
| 2qwgA |
|
|
|
|
|
ASP 151;GLU 277;TYR 406 | mutant R292K | |||
| 2qwhA |
|
|
|
|
|
ASP 151;GLU 277;TYR 406 | mutant R292K | |||
| 2qwiA |
|
|
|
|
|
ASP 151;GLU 277;TYR 406 | ||||
| 2qwjA |
|
|
|
|
|
ASP 151;GLU 277;TYR 406 | mutant R292K | |||
| 2qwkA |
|
|
|
|
|
ASP 151;GLU 277;TYR 406 | ||||
| 3nn9A |
|
|
|
|
|
ASP 151;GLU 277;TYR 406 | mutant N329D | |||
| 4nn9A |
|
|
|
|
|
ASP 151;GLU 277;TYR 406 | mutant I368R | |||
| 5nn9A |
|
|
|
|
|
ASP 151;GLU 277;TYR 406 | mutant A369D | |||
| 6nn9A |
|
|
|
|
|
ASP 151;GLU 277;TYR 406 | mutant K432N | |||
| 7nn9A |
|
|
|
|
|
ASP 151;GLU 277;TYR 406 | ||||
| 1ncdN |
|
|
|
|
|
ASP 151;GLU 277;TYR 406 | ||||
| 1nmaN |
|
|
|
|
|
ASP 151;GLU 277;TYR 406 | ||||
| 1nmbN |
|
|
|
|
|
ASP 151;GLU 277;TYR 406 | ||||
| 1a4gA |
|
|
|
|
|
ASP 148;GLU 275;TYR 408 | ||||
| 1a4gB |
|
|
|
|
|
ASP 148;GLU 275;TYR 408 | ||||
| 1a4qA |
|
|
|
|
|
ASP 148;GLU 275;TYR 408 | ||||
| 1a4qB |
|
|
|
|
|
ASP 148;GLU 275;TYR 408 | ||||
| 1nsbA |
|
|
|
|
|
ASP 148;GLU 275;TYR 408 | ||||
| 1nsbB |
|
|
|
|
|
ASP 148;GLU 275;TYR 408 | ||||
| 1nscA |
|
|
|
|
|
ASP 148;GLU 275;TYR 408 | ||||
| 1nscB |
|
|
|
|
|
ASP 148;GLU 275;TYR 408 | ||||
| 1nsdA |
|
|
|
|
|
ASP 148;GLU 275;TYR 408 | ||||
| 1nsdB |
|
|
|
|
|
ASP 148;GLU 275;TYR 408 | ||||
| References for Catalytic Mechanism | ||
|---|---|---|
| References | Sections | No. of steps in catalysis |
|
[12]
|
||
| References | |
|---|---|
| [1] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 3811232 |
| Journal | Virology |
| Year | 1987 |
| Volume | 156 |
| Pages | 181-4 |
| Authors | Laver WG, Webster RG, Colman PM |
| Title | Crystals of antibodies complexed with influenza virus neuraminidase show isosteric binding of antibody to wild-type and variant antigens. |
| Related PDB | |
| Related UniProtKB | |
| [2] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 2569208 |
| Journal | Philos Trans R Soc Lond B Biol Sci |
| Year | 1989 |
| Volume | 323 |
| Pages | 511-8 |
| Authors | Colman PM, Tulip WR, Varghese JN, Tulloch PA, Baker AT, Laver WG, Air GM, Webster RG |
| Title | Three-dimensional structures of influenza virus neuraminidase-antibody complexes. |
| Related PDB | |
| Related UniProtKB | |
| [3] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1700825 |
| Journal | J Virol |
| Year | 1990 |
| Volume | 64 |
| Pages | 5797-803 |
| Authors | Air GM, Laver WG, Webster RG |
| Title | Mechanism of antigenic variation in an individual epitope on influenza virus N9 neuraminidase. |
| Related PDB | |
| Related UniProtKB | |
| [4] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1866839 |
| Journal | Ultramicroscopy |
| Year | 1991 |
| Volume | 35 |
| Pages | 131-43 |
| Authors | Bullough PA, Tulloch PA |
| Title | Spot-scan imaging of microcrystals of an influenza neuraminidase-antibody fragment complex. |
| Related PDB | |
| Related UniProtKB | |
| [5] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1920429 |
| Journal | J Mol Biol |
| Year | 1991 |
| Volume | 221 |
| Pages | 487-97 |
| Authors | Tulip WR, Varghese JN, Baker AT, van Donkelaar A, Laver WG, Webster RG, Colman PM |
| Title | Refined atomic structures of N9 subtype influenza virus neuraminidase and escape mutants. |
| Related PDB | 3nn9 4nn9 5nn9 6nn9 |
| Related UniProtKB | |
| [6] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1984652 |
| Journal | Virology |
| Year | 1991 |
| Volume | 180 |
| Pages | 266-72 |
| Authors | Burmeister WP, Daniels RS, Dayan S, Gagnon J, Cusack S, Ruigrok RW |
| Title | Sequence and crystallization of influenza virus B/Beijing/1/87 neuraminidase. |
| Related PDB | 1nsb |
| Related UniProtKB | |
| [7] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 1381757 |
| Journal | J Mol Biol |
| Year | 1992 |
| Volume | 227 |
| Pages | 122-48 |
| Authors | Tulip WR, Varghese JN, Laver WG, Webster RG, Colman PM |
| Title | Refined crystal structure of the influenza virus N9 neuraminidase-NC41 Fab complex. |
| Related PDB | 1nca |
| Related UniProtKB | |
| [8] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 1522584 |
| Journal | J Mol Biol |
| Year | 1992 |
| Volume | 227 |
| Pages | 149-59 |
| Authors | Tulip WR, Varghese JN, Webster RG, Laver WG, Colman PM |
| Title | Crystal structures of two mutant neuraminidase-antibody complexes with amino acid substitutions in the interface. |
| Related PDB | 1ncb 1ncc 1ncd |
| Related UniProtKB | |
| [9] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 83-470. |
| Medline ID | 93381688 |
| PubMed ID | 8371267 |
| Journal | J Mol Biol |
| Year | 1993 |
| Volume | 232 |
| Pages | 1069-83 |
| Authors | Bossart-Whitaker P, Carson M, Babu YS, Smith CD, Laver WG, Air GM |
| Title | Three-dimensional structure of influenza A N9 neuraminidase and its complex with the inhibitor 2-deoxy 2,3-dehydro-N-acetyl neuraminic acid. |
| Related PDB | 1nna 1nnb |
| Related UniProtKB | P03472 |
| [10] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8497484 |
| Journal | Proteins |
| Year | 1993 |
| Volume | 16 |
| Pages | 57-63 |
| Authors | Malby RL, Caldwell JB, Gruen LC, Harley VR, Ivancic N, Kortt AA, Lilley GG, Power BE, Webster RG, Colman PM, et al |
| Title |
Recombinant antineuraminidase single chain antibody: expression, |
| Related PDB | |
| Related UniProtKB | |
| [11] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7680132 |
| Journal | Proteins |
| Year | 1993 |
| Volume | 15 |
| Pages | 121-32 |
| Authors | Nuss JM, Whitaker PB, Air GM |
| Title | Identification of critical contact residues in the NC41 epitope of a subtype N9 influenza virus neuraminidase. |
| Related PDB | |
| Related UniProtKB | |
| [12] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8069621 |
| Journal | Structure |
| Year | 1993 |
| Volume | 1 |
| Pages | 19-26 |
| Authors | Burmeister WP, Henrissat B, Bosso C, Cusack S, Ruigrok RW |
| Title | Influenza B virus neuraminidase can synthesize its own inhibitor. |
| Related PDB | 1nsc 1nsd |
| Related UniProtKB | |
| [13] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 7517697 |
| Journal | Biochemistry |
| Year | 1994 |
| Volume | 33 |
| Pages | 7986-97 |
| Authors | Tulip WR, Harley VR, Webster RG, Novotny J |
| Title | N9 neuraminidase complexes with antibodies NC41 and NC10: empirical free energy calculations capture specificity trends observed with mutant binding data. |
| Related PDB | 1nma |
| Related UniProtKB | |
| [14] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8168505 |
| Journal | Eur J Biochem |
| Year | 1994 |
| Volume | 221 |
| Pages | 151-7 |
| Authors | Kortt AA, Malby RL, Caldwell JB, Gruen LC, Ivancic N, Lawrence MC, Howlett GJ, Webster RG, Hudson PJ, Colman PM |
| Title |
Recombinant anti-sialidase single-chain variable fragment antibody. |
| Related PDB | |
| Related UniProtKB | |
| [15] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7507170 |
| Journal | J Mol Biol |
| Year | 1994 |
| Volume | 235 |
| Pages | 747-59 |
| Authors | Nuss JM, Air GM |
| Title | Defining the requirements for an antibody epitope on influenza virus neuraminidase: how tolerant are protein epitopes? |
| Related PDB | |
| Related UniProtKB | |
| [16] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS). |
| Medline ID | 95086861 |
| PubMed ID | 7994573 |
| Journal | Structure |
| Year | 1994 |
| Volume | 2 |
| Pages | 733-46 |
| Authors | Malby RL, Tulip WR, Harley VR, McKimm-Breschkin JL, Laver WG, Webster RG, Colman PM |
| Title | The structure of a complex between the NC10 antibody and influenza virus neuraminidase and comparison with the overlapping binding site of the NC41 antibody. |
| Related PDB | 1nmb |
| Related UniProtKB | P05803 |
| [17] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7576085 |
| Journal | J Protein Chem |
| Year | 1995 |
| Volume | 14 |
| Pages | 167-78 |
| Authors | Kortt AA, Guthrie RE, Hinds MG, Power BE, Ivancic N, Caldwell JB, Gruen LC, Norton RS, Hudson PJ |
| Title | Solution properties of Escherichia coli-expressed VH domain of anti-neuraminidase antibody NC41. |
| Related PDB | |
| Related UniProtKB | |
| [18] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7549872 |
| Journal | Protein Sci |
| Year | 1995 |
| Volume | 4 |
| Pages | 1081-7 |
| Authors | Varghese JN, Epa VC, Colman PM |
| Title | Three-dimensional structure of the complex of 4-guanidino-Neu5Ac2en and influenza virus neuraminidase. |
| Related PDB | 1nnc 7nn9 |
| Related UniProtKB | |
| [19] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7844831 |
| Journal | J Mol Biol |
| Year | 1995 |
| Volume | 245 |
| Pages | 623-34 |
| Authors | White CL, Janakiraman MN, Laver WG, Philippon C, Vasella A, Air GM, Luo M |
| Title | A sialic acid-derived phosphonate analog inhibits different strains of influenza virus neuraminidase with different efficiencies. |
| Related PDB | 1iny |
| Related UniProtKB | |
| [20] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8535779 |
| Journal | Structure |
| Year | 1995 |
| Volume | 3 |
| Pages | 853-9 |
| Authors | Davies G, Henrissat B |
| Title | Structures and mechanisms of glycosyl hydrolases. |
| Related PDB | |
| Related UniProtKB | |
| [21] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8552677 |
| Journal | Proc Natl Acad Sci U S A |
| Year | 1996 |
| Volume | 93 |
| Pages | 7-12 |
| Authors | Davies DR, Cohen GH |
| Title | Interactions of protein antigens with antibodies. |
| Related PDB | |
| Related UniProtKB | |
| [22] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 83-470. |
| Medline ID | 98004480 |
| PubMed ID | 9342319 |
| Journal | Proc Natl Acad Sci U S A |
| Year | 1997 |
| Volume | 94 |
| Pages | 11808-12 |
| Authors | Varghese JN, Colman PM, van Donkelaar A, Blick TJ, Sahasrabudhe A, McKimm-Breschkin JL |
| Title | Structural evidence for a second sialic acid binding site in avian influenza virus neuraminidases. |
| Related PDB | 1mwe |
| Related UniProtKB | P03472 |
| [23] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9194168 |
| Journal | Protein Eng |
| Year | 1997 |
| Volume | 10 |
| Pages | 423-33 |
| Authors | Kortt AA, Lah M, Oddie GW, Gruen CL, Burns JE, Pearce LA, Atwell JL, McCoy AJ, Howlett GJ, Metzger DW, Webster RG, Hudson PJ |
| Title | Single-chain Fv fragments of anti-neuraminidase antibody NC10 containing five- and ten-residue linkers form dimers and with zero-residue linker a trimer. |
| Related PDB | |
| Related UniProtKB | |
| [24] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 9642070 |
| Journal | J Mol Biol |
| Year | 1998 |
| Volume | 279 |
| Pages | 901-10 |
| Authors | Malby RL, McCoy AJ, Kortt AA, Hudson PJ, Colman PM |
| Title | Three-dimensional structures of single-chain Fv-neuraminidase complexes. |
| Related PDB | 1a14 1nmc |
| Related UniProtKB | |
| [25] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9655825 |
| Journal | Structure |
| Year | 1998 |
| Volume | 6 |
| Pages | 735-46 |
| Authors | Varghese JN, Smith PW, Sollis SL, Blick TJ, Sahasrabudhe A, McKimm-Breschkin JL, Colman PM |
| Title | Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase. |
| Related PDB | 2qwa 2qwb 2qwc 2qwd 2qwe 2qwe 2qwf 2qwg 2qwh 2qwi 2qwj 2qwk |
| Related UniProtKB | |
| [26] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9526556 |
| Journal | J Med Chem |
| Year | 1998 |
| Volume | 41 |
| Pages | 798-807 |
| Authors | Taylor NR, Cleasby A, Singh O, Skarzynski T, Wonacott AJ, Smith PW, Sollis SL, Howes PD, Cherry PC, Bethell R, Colman P, Varghese J |
| Title |
Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. |
| Related PDB | 1a4g 1a4q |
| Related UniProtKB | |
| [27] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11274459 |
| Journal | Protein Sci |
| Year | 2001 |
| Volume | 10 |
| Pages | 689-96 |
| Authors | Smith BJ, Colman PM, Von Itzstein M, Danylec B, Varghese JN |
| Title | Analysis of inhibitor binding in influenza virus neuraminidase. |
| Related PDB | 1f8b 1f8c 1f8d 1f8e |
| Related UniProtKB | |
| [28] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12014958 |
| Journal | J Med Chem |
| Year | 2002 |
| Volume | 45 |
| Pages | 2207-12 |
| Authors | Smith BJ, McKimm-Breshkin JL, McDonald M, Fernley RT, Varghese JN, Colman PM |
| Title | Structural studies of the resistance of influenza virus neuramindase to inhibitors. |
| Related PDB | 1l7f 1l7g 1l7h |
| Related UniProtKB | |
| [29] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12054776 |
| Journal | J Mol Biol |
| Year | 2002 |
| Volume | 318 |
| Pages | 161-77 |
| Authors | Sheinerman FB, Honig B |
| Title | On the role of electrostatic interactions in the design of protein-protein interfaces. |
| Related PDB | |
| Related UniProtKB | |
| Comments |
|---|
|
This enzyme belongs to the glycosidase family-34. According to literature [9], Another paper [12] reported that Tyr406 might stabilize the transition state during catalysis. |
| Created | Updated |
|---|---|
| 2004-05-29 | 2009-02-26 |