D00173
type: Enzyme
active site residues resources: Recombinant antineuraminidase single chain antibody: expression, characterization, and crystallization in complex with antigen.
cath: http://ezcatdb.cbrc.jp/EzCatDB/cath/-.-.-.-
cath: Neuraminidase
csa: 1a4g
csa: 7nn9
ec: https://purl.uniprot.org/enzyme/3.2.1.18
kegg enzyme: exo-alpha-sialidase
kegg pathway: N-Glycan degradation
kegg pathway: Sphingolipid metabolism
kegg pathway: Glycan structures - degradation
kegg product: N-Acetylneuraminate
kegg product: Galactosylceramide
kegg product: beta-D-Galactosyl-1,4-beta-D-glucosylceramide
kegg product: GalNAc-beta1->4Gal-beta1->4Glc-beta1->1'Cer
kegg product: D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
kegg product: Neu5Ac-alpha2->3Gal-beta1->3GalNAc-beta1->4(Neu5Ac-alpha2->8Neu5Ac-alpha2->3)Gal-beta1->4Glc-beta1->1'Cer
kegg product: Gal-beta1->3GalNAc-beta1->4(Neu5Ac-alpha2->8Neu5Ac-alpha2->3)Gal-beta1->4Glc-beta1->1'Cer
kegg substrate: H2O
kegg substrate: N-Acetylneuraminyl-galactosylceramide
kegg substrate: (N-Acetylneuraminyl)-D-galactosyl-D-glucosylceramide
kegg substrate: N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
kegg substrate: N-Acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
kegg substrate: Neu5Ac-alpha2->8Neu5Ac-alpha2->3Gal-beta1->3GalNAc-beta1->4(Neu5Ac-alpha2->8Neu5Ac-alpha2->3)Gal-beta1->4Glc-beta1->1'Cer
kegg substrate: Neu5Ac-alpha2->3Gal-beta1->3GalNAc-beta1->4(Neu5Ac-alpha2->8Neu5Ac-alpha2->3)Gal-beta1->4Glc-beta1->1'Cer
pdb: 1a14N
pdb: 1f8bA
pdb: 1f8cA
pdb: 1f8dA
pdb: 1f8eA
pdb: 1inyA
pdb: 1l7fA
pdb: 1l7gA
pdb: 1l7hA
pdb: 1mweA
pdb: 1ncaN
pdb: 1ncbN
pdb: 1nccN
pdb: 1nmcA
pdb: 1nmcN
pdb: 1nnaA
pdb: 1nnbA
pdb: 1nncA
pdb: 2qwaA
pdb: 2qwbA
pdb: 2qwcA
pdb: 2qwdA
pdb: 2qweA
pdb: 2qwfA
pdb: 2qwgA
pdb: 2qwhA
pdb: 2qwiA
pdb: 2qwjA
pdb: 2qwkA
pdb: 3nn9A
pdb: 4nn9A
pdb: 5nn9A
pdb: 6nn9A
pdb: 7nn9A
pdb: 1ncdN
pdb: 1nmaN
pdb: 1nmbN
pdb: 1a4gA
pdb: 1a4gB
pdb: 1a4qA
pdb: 1a4qB
pdb: 1nsbA
pdb: 1nsbB
pdb: 1nscA
pdb: 1nscB
pdb: 1nsdA
pdb: 1nsdB
uniprot: P03472
uniprot: P05803
uniprot: P27907
references: Crystals of antibodies complexed with influenza virus neuraminidase show isosteric binding of antibody to wild-type and variant antigens.
references: Three-dimensional structures of influenza virus neuraminidase-antibody complexes.
references: Mechanism of antigenic variation in an individual epitope on influenza virus N9 neuraminidase.
references: Spot-scan imaging of microcrystals of an influenza neuraminidase-antibody fragment complex.
references: Refined atomic structures of N9 subtype influenza virus neuraminidase and escape mutants.

Neuraminidase
type: Cath
catalytic domain: index.html
references: http://www.cathdb.info/version/latest/superfamily/2.120.10.10

H2O
type: KeggSubstrate
compound type: H2O
references: KEGG:C00001
references: CHEBI:15377
references: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi

N-Glycan degradation
type: KeggPathway
references: KEGG:MAP00511

Sphingolipid metabolism
type: KeggPathway
references: KEGG:MAP00600

Glycan structures - degradation
type: KeggPathway
references: KEGG:MAP01032

Crystals of antibodies complexed with influenza virus neuraminidase show isosteric binding of antibody to wild-type and variant antigens.
type: BibliographicResource
authors:
  item: Laver WG
  item: Webster RG
  item: Colman PM
journal: Virology
pages: 181-4
published year: 1987
volume: 156
references: http://www.ncbi.nlm.nih.gov/pubmed/3811232

Identification of critical contact residues in the NC41 epitope of a subtype N9 influenza virus neuraminidase.
type: BibliographicResource
authors:
  item: Nuss JM
  item: Whitaker PB
  item: Air GM
journal: Proteins
pages: 121-32
published year: 1993
volume: 15
references: http://www.ncbi.nlm.nih.gov/pubmed/7680132

Influenza B virus neuraminidase can synthesize its own inhibitor.
type: BibliographicResource
authors:
  item: Burmeister WP
  item: Henrissat B
  item: Bosso C
  item: Cusack S
  item: Ruigrok RW
journal: Structure
pages: 19-26
published year: 1993
volume: 1
references: http://www.ncbi.nlm.nih.gov/pubmed/8069621
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl

N9 neuraminidase complexes with antibodies NC41 and NC10: empirical free energy calculations capture specificity trends observed with mutant binding data.
type: BibliographicResource
authors:
  item: Tulip WR
  item: Harley VR
  item: Webster RG
  item: Novotny J
journal: Biochemistry
pages: 7986-97
published year: 1994
volume: 33
references: http://www.ncbi.nlm.nih.gov/pubmed/7517697
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
comment: X-ray crystallography

http://ezcatdb.cbrc.jp/EzCatDB/reference/D00173#14
type: BibliographicResource
title: Recombinant anti-sialidase single-chain variable fragment antibody. Characterization, formation of dimer and higher-molecular-mass multimers and the solution of the crystal structure of the single-chain variable fragment/sialidase complex.
authors:
  item: Kortt AA
  item: Colman PM
  item: Malby RL
  item: Caldwell JB
  item: Gruen LC
  item: Ivancic N
  item: Lawrence MC
  item: Howlett GJ
  item: Webster RG
  item: Hudson PJ
journal: Eur J Biochem
pages: 151-7
published year: 1994
volume: 221
references: http://www.ncbi.nlm.nih.gov/pubmed/8168505

Defining the requirements for an antibody epitope on influenza virus neuraminidase: how tolerant are protein epitopes?
type: BibliographicResource
authors:
  item: Nuss JM
  item: Air GM
journal: J Mol Biol
pages: 747-59
published year: 1994
volume: 235
references: http://www.ncbi.nlm.nih.gov/pubmed/7507170

The structure of a complex between the NC10 antibody and influenza virus neuraminidase and comparison with the overlapping binding site of the NC41 antibody.
type: BibliographicResource
authors:
  item: Malby RL
  item: Tulip WR
  item: Harley VR
  item: McKimm-Breschkin JL
  item: Laver WG
  item: Webster RG
  item: Colman PM
journal: Structure
medline id: 95086861
pages: 733-46
published year: 1994
volume: 2
references: http://www.ncbi.nlm.nih.gov/pubmed/7994573
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: P05803
comment: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).

Solution properties of Escherichia coli-expressed VH domain of anti-neuraminidase antibody NC41.
type: BibliographicResource
authors:
  item: Kortt AA
  item: Guthrie RE
  item: Hinds MG
  item: Power BE
  item: Ivancic N
  item: Caldwell JB
  item: Gruen LC
  item: Norton RS
  item: Hudson PJ
journal: J Protein Chem
pages: 167-78
published year: 1995
volume: 14
references: http://www.ncbi.nlm.nih.gov/pubmed/7576085

Three-dimensional structure of the complex of 4-guanidino-Neu5Ac2en and influenza virus neuraminidase.
type: BibliographicResource
authors:
  item: Varghese JN
  item: Epa VC
  item: Colman PM
journal: Protein Sci
pages: 1081-7
published year: 1995
volume: 4
references: http://www.ncbi.nlm.nih.gov/pubmed/7549872
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl

A sialic acid-derived phosphonate analog inhibits different strains of influenza virus neuraminidase with different efficiencies.
type: BibliographicResource
authors:
  item: White CL
  item: Janakiraman MN
  item: Laver WG
  item: Philippon C
  item: Vasella A
  item: Air GM
  item: Luo M
journal: J Mol Biol
pages: 623-34
published year: 1995
volume: 245
references: http://www.ncbi.nlm.nih.gov/pubmed/7844831
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl

Three-dimensional structures of influenza virus neuraminidase-antibody complexes.
type: BibliographicResource
authors:
  item: Colman PM
  item: Tulip WR
  item: Varghese JN
  item: Tulloch PA
  item: Baker AT
  item: Laver WG
  item: Air GM
  item: Webster RG
journal: Philos Trans R Soc Lond B Biol Sci
pages: 511-8
published year: 1989
volume: 323
references: http://www.ncbi.nlm.nih.gov/pubmed/2569208

Structures and mechanisms of glycosyl hydrolases.
type: BibliographicResource
authors:
  item: Davies G
  item: Henrissat B
journal: Structure
pages: 853-9
published year: 1995
volume: 3
references: http://www.ncbi.nlm.nih.gov/pubmed/8535779

Interactions of protein antigens with antibodies.
type: BibliographicResource
authors:
  item: Davies DR
  item: Cohen GH
journal: Proc Natl Acad Sci U S A
pages: 7-12
published year: 1996
volume: 93
references: http://www.ncbi.nlm.nih.gov/pubmed/8552677

Structural evidence for a second sialic acid binding site in avian influenza virus neuraminidases.
type: BibliographicResource
authors:
  item: Varghese JN
  item: Colman PM
  item: van Donkelaar A
  item: Blick TJ
  item: Sahasrabudhe A
  item: McKimm-Breschkin JL
journal: Proc Natl Acad Sci U S A
medline id: 98004480
pages: 11808-12
published year: 1997
volume: 94
references: http://www.ncbi.nlm.nih.gov/pubmed/9342319
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: P03472
comment: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 83-470.

Single-chain Fv fragments of anti-neuraminidase antibody NC10 containing five- and ten-residue linkers form dimers and with zero-residue linker a trimer.
type: BibliographicResource
authors:
  item: Kortt AA
  item: Metzger DW
  item: Webster RG
  item: Hudson PJ
  item: Lah M
  item: Oddie GW
  item: Gruen CL
  item: Burns JE
  item: Pearce LA
  item: Atwell JL
  item: McCoy AJ
  item: Howlett GJ
journal: Protein Eng
pages: 423-33
published year: 1997
volume: 10
references: http://www.ncbi.nlm.nih.gov/pubmed/9194168

Three-dimensional structures of single-chain Fv-neuraminidase complexes.
type: BibliographicResource
authors:
  item: Malby RL
  item: McCoy AJ
  item: Kortt AA
  item: Hudson PJ
  item: Colman PM
journal: J Mol Biol
pages: 901-10
published year: 1998
volume: 279
references: http://www.ncbi.nlm.nih.gov/pubmed/9642070
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
comment: X-ray crystallography

Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
type: BibliographicResource
authors:
  item: Varghese JN
  item: Smith PW
  item: Sollis SL
  item: Blick TJ
  item: Sahasrabudhe A
  item: McKimm-Breschkin JL
  item: Colman PM
journal: Structure
pages: 735-46
published year: 1998
volume: 6
references: http://www.ncbi.nlm.nih.gov/pubmed/9655825
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl

http://ezcatdb.cbrc.jp/EzCatDB/reference/D00173#26
type: BibliographicResource
title: Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B.
authors:
  item: Taylor NR
  item: Bethell R
  item: Colman P
  item: Varghese J
  item: Cleasby A
  item: Singh O
  item: Skarzynski T
  item: Wonacott AJ
  item: Smith PW
  item: Sollis SL
  item: Howes PD
  item: Cherry PC
journal: J Med Chem
pages: 798-807
published year: 1998
volume: 41
references: http://www.ncbi.nlm.nih.gov/pubmed/9526556
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl

Analysis of inhibitor binding in influenza virus neuraminidase.
type: BibliographicResource
authors:
  item: Smith BJ
  item: Colman PM
  item: Von Itzstein M
  item: Danylec B
  item: Varghese JN
journal: Protein Sci
pages: 689-96
published year: 2001
volume: 10
references: http://www.ncbi.nlm.nih.gov/pubmed/11274459
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl

Structural studies of the resistance of influenza virus neuramindase to inhibitors.
type: BibliographicResource
authors:
  item: Smith BJ
  item: McKimm-Breshkin JL
  item: McDonald M
  item: Fernley RT
  item: Varghese JN
  item: Colman PM
journal: J Med Chem
pages: 2207-12
published year: 2002
volume: 45
references: http://www.ncbi.nlm.nih.gov/pubmed/12014958
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl

On the role of electrostatic interactions in the design of protein-protein interfaces.
type: BibliographicResource
authors:
  item: Sheinerman FB
  item: Honig B
journal: J Mol Biol
pages: 161-77
published year: 2002
volume: 318
references: http://www.ncbi.nlm.nih.gov/pubmed/12054776

Mechanism of antigenic variation in an individual epitope on influenza virus N9 neuraminidase.
type: BibliographicResource
authors:
  item: Air GM
  item: Laver WG
  item: Webster RG
journal: J Virol
pages: 5797-803
published year: 1990
volume: 64
references: http://www.ncbi.nlm.nih.gov/pubmed/1700825

Spot-scan imaging of microcrystals of an influenza neuraminidase-antibody fragment complex.
type: BibliographicResource
authors:
  item: Bullough PA
  item: Tulloch PA
journal: Ultramicroscopy
pages: 131-43
published year: 1991
volume: 35
references: http://www.ncbi.nlm.nih.gov/pubmed/1866839

Refined atomic structures of N9 subtype influenza virus neuraminidase and escape mutants.
type: BibliographicResource
authors:
  item: Tulip WR
  item: Varghese JN
  item: Baker AT
  item: van Donkelaar A
  item: Laver WG
  item: Webster RG
  item: Colman PM
journal: J Mol Biol
pages: 487-97
published year: 1991
volume: 221
references: http://www.ncbi.nlm.nih.gov/pubmed/1920429
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl

Sequence and crystallization of influenza virus B/Beijing/1/87 neuraminidase.
type: BibliographicResource
authors:
  item: Burmeister WP
  item: Daniels RS
  item: Dayan S
  item: Gagnon J
  item: Cusack S
  item: Ruigrok RW
journal: Virology
pages: 266-72
published year: 1991
volume: 180
references: http://www.ncbi.nlm.nih.gov/pubmed/1984652
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl

Refined crystal structure of the influenza virus N9 neuraminidase-NC41 Fab complex.
type: BibliographicResource
authors:
  item: Tulip WR
  item: Varghese JN
  item: Laver WG
  item: Webster RG
  item: Colman PM
journal: J Mol Biol
pages: 122-48
published year: 1992
volume: 227
references: http://www.ncbi.nlm.nih.gov/pubmed/1381757
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
comment: X-ray crystallography

Crystal structures of two mutant neuraminidase-antibody complexes with amino acid substitutions in the interface.
type: BibliographicResource
authors:
  item: Tulip WR
  item: Varghese JN
  item: Webster RG
  item: Laver WG
  item: Colman PM
journal: J Mol Biol
pages: 149-59
published year: 1992
volume: 227
references: http://www.ncbi.nlm.nih.gov/pubmed/1522584
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
comment: X-ray crystallography

Three-dimensional structure of influenza A N9 neuraminidase and its complex with the inhibitor 2-deoxy 2,3-dehydro-N-acetyl neuraminic acid.
type: BibliographicResource
authors:
  item: Bossart-Whitaker P
  item: Carson M
  item: Babu YS
  item: Smith CD
  item: Laver WG
  item: Air GM
journal: J Mol Biol
medline id: 93381688
pages: 1069-83
published year: 1993
volume: 232
references: http://www.ncbi.nlm.nih.gov/pubmed/8371267
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: P03472
comment: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 83-470.

Recombinant antineuraminidase single chain antibody: expression, characterization, and crystallization in complex with antigen.
type: BibliographicResource
authors:
  item: Malby RL
  item: Colman PM
  item: et al
  item: Caldwell JB
  item: Gruen LC
  item: Harley VR
  item: Ivancic N
  item: Kortt AA
  item: Lilley GG
  item: Power BE
  item: Webster RG
journal: Proteins
pages: 57-63
published year: 1993
volume: 16
references: http://www.ncbi.nlm.nih.gov/pubmed/8497484

1mweA
type: Pdb
catalytic residue: ASP 151;GLU 277;TYR 406
references: 1mwe
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1mwe

1nscA
type: Pdb
catalytic residue: ASP 148;GLU 275;TYR 408
references: 1nsc
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1nsc

1nscB
type: Pdb
catalytic residue: ASP 148;GLU 275;TYR 408
references: 1nsc
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1nsc

2qwbA
type: Pdb
catalytic residue: ASP 151;GLU 277;TYR 406
references: 2qwb
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:2qwb
comment: mutant R292K

1a14N
type: Pdb
catalytic residue: ASP 151;GLU 277;TYR 406
references: 1a14
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1a14

1a4gA
type: Pdb
catalytic residue: ASP 148;GLU 275;TYR 408
references: 1a4g
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1a4g

1a4gB
type: Pdb
catalytic residue: ASP 148;GLU 275;TYR 408
references: 1a4g
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1a4g

1a4qA
type: Pdb
catalytic residue: ASP 148;GLU 275;TYR 408
references: 1a4q
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1a4q

1a4qB
type: Pdb
catalytic residue: ASP 148;GLU 275;TYR 408
references: 1a4q
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1a4q

1f8bA
type: Pdb
catalytic residue: ASP 151;GLU 277;TYR 406
references: 1f8b
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1f8b

1f8cA
type: Pdb
catalytic residue: ASP 151;GLU 277;TYR 406
references: 1f8c
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1f8c

1f8dA
type: Pdb
catalytic residue: ASP 151;GLU 277;TYR 406
references: 1f8d
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1f8d

1f8eA
type: Pdb
catalytic residue: ASP 151;GLU 277;TYR 406
references: 1f8e
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1f8e

1inyA
type: Pdb
catalytic residue: ASP 151;GLU 278;TYR 405
references: 1iny
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1iny

1l7fA
type: Pdb
catalytic residue: ASP 151;GLU 277;TYR 406
references: 1l7f
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1l7f

1l7gA
type: Pdb
catalytic residue: ASP 151;GLU 277;TYR 406
references: 1l7g
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1l7g
comment: mutant E119G

1l7hA
type: Pdb
catalytic residue: ASP 151;GLU 277;TYR 406
references: 1l7h
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1l7h
comment: mutant R292K

1ncaN
type: Pdb
catalytic residue: ASP 151;GLU 277;TYR 406
references: 1nca
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1nca

1ncbN
type: Pdb
catalytic residue: ASP 151;GLU 277;TYR 406
references: 1ncb
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1ncb
comment: mutant N329D

1nccN
type: Pdb
catalytic residue: ASP 151;GLU 277;TYR 406
references: 1ncc
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1ncc
comment: mutant I368R

1ncdN
type: Pdb
catalytic residue: ASP 151;GLU 277;TYR 406
references: 1ncd
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1ncd

1nmaN
type: Pdb
catalytic residue: ASP 151;GLU 277;TYR 406
references: 1nma
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1nma

1nmbN
type: Pdb
catalytic residue: ASP 151;GLU 277;TYR 406
references: 1nmb
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1nmb

1nmcA
type: Pdb
catalytic residue: ASP 151;GLU 277;TYR 406
references: 1nmc
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1nmc

1nmcN
type: Pdb
catalytic residue: ASP 151;GLU 277;TYR 406
references: 1nmc
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1nmc

1nnaA
type: Pdb
catalytic residue: ASP 152;GLU 279;TYR 406
references: 1nna
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1nna

1nnbA
type: Pdb
catalytic residue: ASP 152;GLU 279;TYR 406
references: 1nnb
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1nnb

1nncA
type: Pdb
catalytic residue: ASP 151;GLU 277;TYR 406
references: 1nnc
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1nnc

1nsbA
type: Pdb
catalytic residue: ASP 148;GLU 275;TYR 408
references: 1nsb
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1nsb

1nsbB
type: Pdb
catalytic residue: ASP 148;GLU 275;TYR 408
references: 1nsb
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1nsb

1nsdA
type: Pdb
catalytic residue: ASP 148;GLU 275;TYR 408
references: 1nsd
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1nsd

1nsdB
type: Pdb
catalytic residue: ASP 148;GLU 275;TYR 408
references: 1nsd
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1nsd

2qwaA
type: Pdb
catalytic residue: ASP 151;GLU 277;TYR 406
references: 2qwa
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:2qwa
comment: mutant R292K

2qwcA
type: Pdb
catalytic residue: ASP 151;GLU 277;TYR 406
references: 2qwc
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:2qwc
comment: mutant R292K

2qwdA
type: Pdb
catalytic residue: ASP 151;GLU 277;TYR 406
references: 2qwd
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:2qwd
comment: mutant R292K

2qweA
type: Pdb
catalytic residue: ASP 151;GLU 277;TYR 406
references: 2qwe
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:2qwe
comment: mutant R292K

2qwfA
type: Pdb
catalytic residue: ASP 151;GLU 277;TYR 406
references: 2qwf
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:2qwf
comment: mutant R292K

2qwgA
type: Pdb
catalytic residue: ASP 151;GLU 277;TYR 406
references: 2qwg
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:2qwg
comment: mutant R292K

2qwhA
type: Pdb
catalytic residue: ASP 151;GLU 277;TYR 406
references: 2qwh
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:2qwh
comment: mutant R292K

2qwiA
type: Pdb
catalytic residue: ASP 151;GLU 277;TYR 406
references: 2qwi
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:2qwi

2qwjA
type: Pdb
catalytic residue: ASP 151;GLU 277;TYR 406
references: 2qwj
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:2qwj
comment: mutant R292K

2qwkA
type: Pdb
catalytic residue: ASP 151;GLU 277;TYR 406
references: 2qwk
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:2qwk

3nn9A
type: Pdb
catalytic residue: ASP 151;GLU 277;TYR 406
references: 3nn9
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:3nn9
comment: mutant N329D

4nn9A
type: Pdb
catalytic residue: ASP 151;GLU 277;TYR 406
references: 4nn9
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:4nn9
comment: mutant I368R

5nn9A
type: Pdb
catalytic residue: ASP 151;GLU 277;TYR 406
references: 5nn9
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:5nn9
comment: mutant A369D

6nn9A
type: Pdb
catalytic residue: ASP 151;GLU 277;TYR 406
references: 6nn9
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:6nn9
comment: mutant K432N

7nn9A
type: Pdb
catalytic residue: ASP 151;GLU 277;TYR 406
references: 7nn9
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:7nn9

N-Acetylneuraminate
type: KeggProduct
compound type: amide group
compound type: carbohydrate
compound type: carboxyl group
references: KEGG:C00270
references: CHEBI:17012
references: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi

beta-D-Galactosyl-1,4-beta-D-glucosylceramide
type: KeggProduct
compound type: amide group
compound type: carbohydrate
compound type: lipid
compound type: polysaccharide
references: KEGG:C01290

Galactosylceramide
type: KeggProduct
compound type: amide group
compound type: carbohydrate
compound type: lipid
references: KEGG:C02686

(N-Acetylneuraminyl)-D-galactosyl-D-glucosylceramide
type: KeggSubstrate
compound type: amide group
compound type: carbohydrate
compound type: carboxyl group
compound type: lipid
compound type: polysaccharide
references: KEGG:C04730

N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
type: KeggSubstrate
compound type: amide group
compound type: carbohydrate
compound type: carboxyl group
compound type: lipid
compound type: polysaccharide
references: KEGG:C04884

D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
type: KeggProduct
compound type: amide group
compound type: carbohydrate
compound type: carboxyl group
compound type: lipid
compound type: polysaccharide
references: KEGG:C04911

N-Acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
type: KeggSubstrate
compound type: amide group
compound type: carbohydrate
compound type: carboxyl group
compound type: lipid
compound type: polysaccharide
references: KEGG:C04927

N-Acetylneuraminyl-galactosylceramide
type: KeggSubstrate
compound type: amide group
compound type: carbohydrate
compound type: carboxyl group
compound type: lipid
references: KEGG:C06128

GalNAc-beta1->4Gal-beta1->4Glc-beta1->1'Cer
type: KeggProduct
compound type: amide group
compound type: carbohydrate
compound type: lipid
compound type: polysaccharide
references: KEGG:C06135

Neu5Ac-alpha2->8Neu5Ac-alpha2->3Gal-beta1->3GalNAc-beta1->4(Neu5Ac-alpha2->8Neu5Ac-alpha2->3)Gal-beta1->4Glc-beta1->1'Cer
type: KeggSubstrate
compound type: amide group
compound type: carbohydrate
compound type: carboxyl group
compound type: lipid
compound type: polysaccharide
references: KEGG:C06139

Gal-beta1->3GalNAc-beta1->4(Neu5Ac-alpha2->8Neu5Ac-alpha2->3)Gal-beta1->4Glc-beta1->1'Cer
type: KeggProduct
compound type: amide group
compound type: carbohydrate
compound type: carboxyl group
compound type: lipid
compound type: polysaccharide
references: KEGG:C06141

Neu5Ac-alpha2->3Gal-beta1->3GalNAc-beta1->4(Neu5Ac-alpha2->8Neu5Ac-alpha2->3)Gal-beta1->4Glc-beta1->1'Cer
type: KeggSubstrate
type: KeggProduct
compound type: amide group
compound type: carbohydrate
compound type: carboxyl group
compound type: lipid
compound type: polysaccharide
references: KEGG:C06140

neuraminidase
type: KeggEnzyme

sialidase
type: KeggEnzyme

alpha-neuraminidase
type: KeggEnzyme

acetylneuraminidase
type: KeggEnzyme

Analogue
compound: N-Acetylneuraminate
ligand het code: EQP
pdb: 1inyA

Analogue
compound: N-Acetylneuraminate
ligand het code: BCZ
pdb: 1l7fA

Analogue
compound: N-Acetylneuraminate
ligand het code: BCZ
pdb: 1l7gA

Analogue
compound: N-Acetylneuraminate
ligand het code: BCZ
pdb: 1l7hA

Analogue
compound: N-Acetylneuraminate
ligand het code: ZMR
pdb: 1nncA

Analogue
compound: N-Acetylneuraminate
ligand het code: GNA
pdb: 2qweA

Analogue
compound: N-Acetylneuraminate
ligand het code: G28
pdb: 2qwgA

Analogue
compound: N-Acetylneuraminate
ligand het code: G28
pdb: 2qwjA

TransitionStateAnalogue
ligand het code: DAN
pdb: 1f8bA

TransitionStateAnalogue
ligand het code: 4AM
pdb: 1f8cA

TransitionStateAnalogue
ligand het code: 9AM
pdb: 1f8dA

TransitionStateAnalogue
ligand het code: 49A
pdb: 1f8eA

TransitionStateAnalogue
ligand het code: DAN
pdb: 1nnbA

TransitionStateAnalogue
ligand het code: DAN
pdb: 2qwcA

TransitionStateAnalogue
ligand het code: 4AM
pdb: 2qwdA

TransitionStateAnalogue
ligand het code: G20
pdb: 2qwfA

TransitionStateAnalogue
ligand het code: G39
pdb: 2qwhA

TransitionStateAnalogue
ligand het code: G20
pdb: 2qwiA

TransitionStateAnalogue
ligand het code: G39
pdb: 2qwkA

TransitionStateAnalogue
ligand het code: ZMR
pdb: 1a4gA

TransitionStateAnalogue
ligand het code: ZMR
pdb: 1a4gB

TransitionStateAnalogue
ligand het code: DPC
pdb: 1a4qA

TransitionStateAnalogue
ligand het code: DPC
pdb: 1a4qB

TransitionStateAnalogue
ligand het code: DAN
pdb: 1nsdA

TransitionStateAnalogue
ligand het code: DAN
pdb: 1nsdB

ReferenceForCatalyticMechanism
reference index: 12