DB code: T00206
| CATH domain | 3.10.450.40 : Nuclear Transport Factor 2; Chain | |
|---|---|---|
| 3.10.450.40 : Nuclear Transport Factor 2; Chain | ||
| 2.70.98.20 : Beta-galactosidase; Chain A, domain 5 | Catalytic domain | |
| E.C. | 1.4.3.21 | |
| CSA | ||
| M-CSA | ||
| MACiE | ||
| CATH domain | Related DB codes (homologues) |
|---|---|
| 3.10.450.40 : Nuclear Transport Factor 2; Chain | M00103 M00202 T00250 T00251 |
| 2.70.98.20 : Beta-galactosidase; Chain A, domain 5 | M00103 M00202 T00250 T00251 |
| Uniprot Enzyme Name | UniprotKB | Protein name | Synonyms | Pfam |
|---|---|---|---|
| P46881 |
Phenylethylamine oxidase
|
EC
1.4.3.21
Primary amine oxidase |
PF01179
(Cu_amine_oxid)
PF02728 (Cu_amine_oxidN3) [Graphical View] |
| P12807 |
Peroxisomal primary amine oxidase
|
EC
1.4.3.21
Copper amine oxidase Methylamine oxidase |
PF01179
(Cu_amine_oxid)
PF02727 (Cu_amine_oxidN2) PF02728 (Cu_amine_oxidN3) [Graphical View] |
| KEGG enzyme name |
|---|
|
primary-amine oxidase
amine oxidase (ambiguous) amine oxidase (copper-containing) amine oxidase (pyridoxal containing) (incorrect) benzylamine oxidase (incorrect) CAO (ambiguous) copper amine oxidase (ambiguous) Cu-amine oxidase (ambiguous) Cu-containing amine oxidase (ambiguous) diamine oxidase (incorrect) diamino oxhydrase (incorrect) histamine deaminase (ambiguous) histamine oxidase (ambiguous) monoamine oxidase (ambiguous) plasma monoamine oxidase (ambiguous) polyamine oxidase (ambiguous) semicarbazide-sensitive amine oxidase (ambiguous) SSAO (ambiguous) |
| UniprotKB: Accession Number | Entry name | Activity | Subunit | Subcellular location | Cofactor |
|---|---|---|---|---|---|
| P46881 | PAOX_ARTGO | RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2). | Homodimer. | Binds 1 copper ion per subunit. Contains 1 topaquinone per subunit. | |
| P12807 | AMO_PICAN | RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2). | Homodimer. | Peroxisome. | Binds 1 copper ion per subunit. Contains 1 topaquinone per subunit. |
| KEGG Pathways | Map code | Pathways | E.C. |
|---|---|---|
| MAP00260 | Glycine, serine and threonine metabolism | |
| MAP00350 | Tyrosine metabolism | |
| MAP00360 | Phenylalanine metabolism | |
| MAP00410 | beta-Alanine metabolism | |
| MAP00960 | Alkaloid biosynthesis II |
| Compound table | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cofactors | Substrates | Products | Intermediates | |||||||||||||||
| KEGG-id | C00070 | L00003 | C00375 | C00001 | C00007 | C00071 | C00014 | C00027 | I00021 | I00022 | I00023 | I00024 | ||||||
| E.C. | ||||||||||||||||||
| Compound | Copper | Topaquinone | RCH2NH2 | H2O | Oxygen | Aldehyde | NH3 | H2O2 | Substrate Schiff-base (Iminoquinone=substrate) | Carbanionic intermediate | Product Schiff-base (Aminoquinol=product) | Aminoquinol/Semiquinone | Iminoquinone | |||||
| Type | heavy metal | amino acids,aromatic ring (only carbon atom) | amine group | H2O | others | carbohydrate | amine group,organic ion | others | ||||||||||
| ChEBI |
28694 30052 28694 30052 |
36077 68431 36077 68431 |
15377 15377 |
15379 26689 27140 15379 26689 27140 |
16134 16134 |
16240 16240 |
||||||||||||
| PubChem |
23978 23978 |
22247451 962 22247451 962 |
977 977 |
222 222 |
22326046 784 22326046 784 |
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| 1av4A01 |
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| 1avkA01 |
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| 1avlA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1iqxA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1iqxB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1iqyA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1iqyB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1iu7A01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1iu7B01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ivuA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ivuB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ivvA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ivvB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ivwA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ivwB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ivxA01 |
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| 1ivxB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1rjoA01 |
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| 1sihA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1siiA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ui7A01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ui7B01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ui8A01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ui8B01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1w4nA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1w4nB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1w5zA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1w6cA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1w6gA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1wmnA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1wmnB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1wmoA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1wmoB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1wmpA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1wmpB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2bt3A01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cfdA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cfdB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cfgA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cfgB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cfkA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cflA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cfwA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cg0A01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cg1A01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cwtA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cwtB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cwuA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cwuB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cwvA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cwvB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2d1wA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2d1wB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2e2tA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2e2uA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2e2uB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2e2vA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2e2vB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1a2vA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1a2vB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1a2vC01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1a2vD01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1a2vE01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1a2vF01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ekmA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ekmB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ekmC01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2oovA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2oovB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2oovC01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2oovD01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2oovE01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2oovF01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2oqeA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2oqeB01 |
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| 2oqeC01 |
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| 2oqeD01 |
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| 2oqeE01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2oqeF01 |
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| 1av4A02 |
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| 1avkA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1avlA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1iqxA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1iqxB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1iqyA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1iqyB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1iu7A02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1iu7B02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ivuA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ivuB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ivvA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ivvB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ivwA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ivwB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ivxA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ivxB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1rjoA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1sihA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1siiA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ui7A02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ui7B02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ui8A02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ui8B02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1w4nA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1w4nB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1w5zA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1w6cA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1w6gA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1wmnA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1wmnB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1wmoA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1wmoB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1wmpA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1wmpB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2bt3A02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cfdA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cfdB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cfgA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cfgB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cfkA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cflA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cfwA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cg0A02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cg1A02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cwtA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cwtB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cwuA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cwuB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cwvA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cwvB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2d1wA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2d1wB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2e2tA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2e2uA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2e2uB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2e2vA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2e2vB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1a2vA02 |
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|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1a2vB02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1a2vC02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1a2vD02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1a2vE02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1a2vF02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ekmA02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ekmB02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ekmC02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2oovA02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2oovB02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2oovC02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2oovD02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2oovE02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2oovF02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2oqeA02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2oqeB02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2oqeC02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2oqeD02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2oqeE02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2oqeF02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1av4A03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1avkA03 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1avlA03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1iqxA03 |
|
|
|
|
|
Analogue:_CO | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1iqxB03 |
|
|
|
|
|
Analogue:_CO | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1iqyA03 |
|
|
|
|
|
Analogue:_NI | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1iqyB03 |
|
|
|
|
|
Analogue:_NI | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1iu7A03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1iu7B03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ivuA03 |
|
|
|
|
|
Bound:_CU | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ivuB03 |
|
|
|
|
|
Bound:_CU | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ivvA03 |
|
|
|
|
|
Bound:_CU | Analogue:DAH | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ivvB03 |
|
|
|
|
|
Bound:_CU | Analogue:DAH | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ivwA03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ivwB03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ivxA03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ivxB03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1rjoA03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1sihA03 |
|
|
|
|
|
Bound:_CU | Analogue:MBQ | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:MBQ | |||||
| 1siiA03 |
|
|
|
|
|
Bound:_CU | Analogue:NBQ | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:NBQ | |||||
| 1ui7A03 |
|
|
|
|
|
Bound:_CU | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ui7B03 |
|
|
|
|
|
Bound:_CU | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ui8A03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ui8B03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1w4nA03 |
|
|
|
|
|
Bound:_CU | Analogue:TCQ | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:TCQ | |||||
| 1w4nB03 |
|
|
|
|
|
Bound:_CU | Analogue:TCQ | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:TCQ | |||||
| 1w5zA03 |
|
|
|
|
|
Bound:_CU | Analogue:3TY | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:3TY | |||||
| 1w6cA03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1w6gA03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1wmnA03 |
|
|
|
|
|
Analogue:_CO | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1wmnB03 |
|
|
|
|
|
Analogue:_CO | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1wmoA03 |
|
|
|
|
|
Analogue:_NI | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1wmoB03 |
|
|
|
|
|
Analogue:_NI | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1wmpA03 |
|
|
|
|
|
Analogue:_CO | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1wmpB03 |
|
|
|
|
|
Analogue:_CO | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2bt3A03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cfdA03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cfdB03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cfgA03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cfgB03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cfkA03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cflA03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cfwA03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cg0A03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cg1A03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cwtA03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cwtB03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2cwuA03 |
|
|
|
|
|
Bound:_CU | Analogue:1TY | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:1TY | |||||
| 2cwuB03 |
|
|
|
|
|
Bound:_CU | Analogue:1TY | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:1TY | |||||
| 2cwvA03 |
|
|
|
|
|
Bound:_CU | Analogue:2TY | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:2TY | |||||
| 2cwvB03 |
|
|
|
|
|
Bound:_CU | Analogue:2TY | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:2TY | |||||
| 2d1wA03 |
|
|
|
|
|
Bound:_CU | Analogue:TTS | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:TTS | |||||
| 2d1wB03 |
|
|
|
|
|
Bound:_CU | Analogue:TTS | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:TTS | |||||
| 2e2tA03 |
|
|
|
|
|
Bound:_CU | Analogue:OTY | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:OTY-PHZ | |||||
| 2e2uA03 |
|
|
|
|
|
Bound:_CU | Analogue:OTY | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:OTY-4HL | |||||
| 2e2uB03 |
|
|
|
|
|
Bound:_CU | Analogue:OTY | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:OTY-4HL | |||||
| 2e2vA03 |
|
|
|
|
|
Bound:_CU | Analogue:OTY | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:OTY-BZZ | |||||
| 2e2vB03 |
|
|
|
|
|
Bound:_CU | Analogue:OTY | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:OTY-BZZ | |||||
| 1a2vA03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1a2vB03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1a2vC03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1a2vD03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1a2vE03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1a2vF03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ekmA03 |
|
|
|
|
|
Analogue:_ZN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ekmB03 |
|
|
|
|
|
Analogue:_ZN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 1ekmC03 |
|
|
|
|
|
Analogue:_ZN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2oovA03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2oovB03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2oovC03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2oovD03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2oovE03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2oovF03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2oqeA03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2oqeB03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2oqeC03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2oqeD03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2oqeE03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| 2oqeF03 |
|
|
|
|
|
Bound:_CU | Bound:TPQ | Unbound | Unbound | Unbound | Unbound | Unbound | ||||||
| Reference for Active-site residues | ||
|---|---|---|
| resource | references | E.C. |
| Swiss-prot;Q43077, P12807, P46881 | ||
| Active-site residues | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Catalytic residues | Cofactor-binding residues | Modified residues | Main-chain involved in catalysis | Comment | |||||
| 1av4A01 |
|
|
|
|
|
|||||
| 1avkA01 |
|
|
|
|
|
|||||
| 1avlA01 |
|
|
|
|
|
|||||
| 1iqxA01 |
|
|
|
|
|
|||||
| 1iqxB01 |
|
|
|
|
|
|||||
| 1iqyA01 |
|
|
|
|
|
|||||
| 1iqyB01 |
|
|
|
|
|
|||||
| 1iu7A01 |
|
|
|
|
|
|||||
| 1iu7B01 |
|
|
|
|
|
|||||
| 1ivuA01 |
|
|
|
|
|
|||||
| 1ivuB01 |
|
|
|
|
|
|||||
| 1ivvA01 |
|
|
|
|
|
|||||
| 1ivvB01 |
|
|
|
|
|
|||||
| 1ivwA01 |
|
|
|
|
|
|||||
| 1ivwB01 |
|
|
|
|
|
|||||
| 1ivxA01 |
|
|
|
|
|
|||||
| 1ivxB01 |
|
|
|
|
|
|||||
| 1rjoA01 |
|
|
|
|
|
|||||
| 1sihA01 |
|
|
|
|
|
|||||
| 1siiA01 |
|
|
|
|
|
|||||
| 1ui7A01 |
|
|
|
|
|
|||||
| 1ui7B01 |
|
|
|
|
|
|||||
| 1ui8A01 |
|
|
|
|
|
|||||
| 1ui8B01 |
|
|
|
|
|
|||||
| 1w4nA01 |
|
|
|
|
|
|||||
| 1w4nB01 |
|
|
|
|
|
|||||
| 1w5zA01 |
|
|
|
|
|
|||||
| 1w6cA01 |
|
|
|
|
|
|||||
| 1w6gA01 |
|
|
|
|
|
|||||
| 1wmnA01 |
|
|
|
|
|
|||||
| 1wmnB01 |
|
|
|
|
|
|||||
| 1wmoA01 |
|
|
|
|
|
|||||
| 1wmoB01 |
|
|
|
|
|
|||||
| 1wmpA01 |
|
|
|
|
|
|||||
| 1wmpB01 |
|
|
|
|
|
|||||
| 2bt3A01 |
|
|
|
|
|
|||||
| 2cfdA01 |
|
|
|
|
|
|||||
| 2cfdB01 |
|
|
|
|
|
|||||
| 2cfgA01 |
|
|
|
|
|
|||||
| 2cfgB01 |
|
|
|
|
|
|||||
| 2cfkA01 |
|
|
|
|
|
|||||
| 2cflA01 |
|
|
|
|
|
|||||
| 2cfwA01 |
|
|
|
|
|
|||||
| 2cg0A01 |
|
|
|
|
|
|||||
| 2cg1A01 |
|
|
|
|
|
|||||
| 2cwtA01 |
|
|
|
|
|
|||||
| 2cwtB01 |
|
|
|
|
|
|||||
| 2cwuA01 |
|
|
|
|
|
|||||
| 2cwuB01 |
|
|
|
|
|
|||||
| 2cwvA01 |
|
|
|
|
|
|||||
| 2cwvB01 |
|
|
|
|
|
|||||
| 2d1wA01 |
|
|
|
|
|
|||||
| 2d1wB01 |
|
|
|
|
|
|||||
| 2e2tA01 |
|
|
|
|
|
|||||
| 2e2uA01 |
|
|
|
|
|
|||||
| 2e2uB01 |
|
|
|
|
|
|||||
| 2e2vA01 |
|
|
|
|
|
|||||
| 2e2vB01 |
|
|
|
|
|
|||||
| 1a2vA01 |
|
|
|
|
|
|||||
| 1a2vB01 |
|
|
|
|
|
|||||
| 1a2vC01 |
|
|
|
|
|
|||||
| 1a2vD01 |
|
|
|
|
|
|||||
| 1a2vE01 |
|
|
|
|
|
|||||
| 1a2vF01 |
|
|
|
|
|
|||||
| 1ekmA01 |
|
|
|
|
|
|||||
| 1ekmB01 |
|
|
|
|
|
|||||
| 1ekmC01 |
|
|
|
|
|
|||||
| 2oovA01 |
|
|
|
|
|
|||||
| 2oovB01 |
|
|
|
|
|
|||||
| 2oovC01 |
|
|
|
|
|
|||||
| 2oovD01 |
|
|
|
|
|
|||||
| 2oovE01 |
|
|
|
|
|
|||||
| 2oovF01 |
|
|
|
|
|
|||||
| 2oqeA01 |
|
|
|
|
|
|||||
| 2oqeB01 |
|
|
|
|
|
|||||
| 2oqeC01 |
|
|
|
|
|
|||||
| 2oqeD01 |
|
|
|
|
|
|||||
| 2oqeE01 |
|
|
|
|
|
|||||
| 2oqeF01 |
|
|
|
|
|
|||||
| 1av4A02 |
|
|
|
|
|
|||||
| 1avkA02 |
|
|
|
|
|
|||||
| 1avlA02 |
|
|
|
|
|
|||||
| 1iqxA02 |
|
|
|
|
|
|||||
| 1iqxB02 |
|
|
|
|
|
|||||
| 1iqyA02 |
|
|
|
|
|
|||||
| 1iqyB02 |
|
|
|
|
|
|||||
| 1iu7A02 |
|
|
|
|
|
|||||
| 1iu7B02 |
|
|
|
|
|
|||||
| 1ivuA02 |
|
|
|
|
|
|||||
| 1ivuB02 |
|
|
|
|
|
|||||
| 1ivvA02 |
|
|
|
|
|
|||||
| 1ivvB02 |
|
|
|
|
|
|||||
| 1ivwA02 |
|
|
|
|
|
|||||
| 1ivwB02 |
|
|
|
|
|
|||||
| 1ivxA02 |
|
|
|
|
|
|||||
| 1ivxB02 |
|
|
|
|
|
|||||
| 1rjoA02 |
|
|
|
|
|
|||||
| 1sihA02 |
|
|
|
|
|
|||||
| 1siiA02 |
|
|
|
|
|
|||||
| 1ui7A02 |
|
|
|
|
|
|||||
| 1ui7B02 |
|
|
|
|
|
|||||
| 1ui8A02 |
|
|
|
|
|
|||||
| 1ui8B02 |
|
|
|
|
|
|||||
| 1w4nA02 |
|
|
|
|
|
|||||
| 1w4nB02 |
|
|
|
|
|
|||||
| 1w5zA02 |
|
|
|
|
|
|||||
| 1w6cA02 |
|
|
|
|
|
|||||
| 1w6gA02 |
|
|
|
|
|
|||||
| 1wmnA02 |
|
|
|
|
|
|||||
| 1wmnB02 |
|
|
|
|
|
|||||
| 1wmoA02 |
|
|
|
|
|
|||||
| 1wmoB02 |
|
|
|
|
|
|||||
| 1wmpA02 |
|
|
|
|
|
|||||
| 1wmpB02 |
|
|
|
|
|
|||||
| 2bt3A02 |
|
|
|
|
|
|||||
| 2cfdA02 |
|
|
|
|
|
|||||
| 2cfdB02 |
|
|
|
|
|
|||||
| 2cfgA02 |
|
|
|
|
|
|||||
| 2cfgB02 |
|
|
|
|
|
|||||
| 2cfkA02 |
|
|
|
|
|
|||||
| 2cflA02 |
|
|
|
|
|
|||||
| 2cfwA02 |
|
|
|
|
|
|||||
| 2cg0A02 |
|
|
|
|
|
|||||
| 2cg1A02 |
|
|
|
|
|
|||||
| 2cwtA02 |
|
|
|
|
|
|||||
| 2cwtB02 |
|
|
|
|
|
|||||
| 2cwuA02 |
|
|
|
|
|
|||||
| 2cwuB02 |
|
|
|
|
|
|||||
| 2cwvA02 |
|
|
|
|
|
|||||
| 2cwvB02 |
|
|
|
|
|
|||||
| 2d1wA02 |
|
|
|
|
|
|||||
| 2d1wB02 |
|
|
|
|
|
|||||
| 2e2tA02 |
|
|
|
|
|
|||||
| 2e2uA02 |
|
|
|
|
|
|||||
| 2e2uB02 |
|
|
|
|
|
|||||
| 2e2vA02 |
|
|
|
|
|
|||||
| 2e2vB02 |
|
|
|
|
|
|||||
| 1a2vA02 |
|
|
|
|
|
|||||
| 1a2vB02 |
|
|
|
|
|
|||||
| 1a2vC02 |
|
|
|
|
|
|||||
| 1a2vD02 |
|
|
|
|
|
|||||
| 1a2vE02 |
|
|
|
|
|
|||||
| 1a2vF02 |
|
|
|
|
|
|||||
| 1ekmA02 |
|
|
|
|
|
|||||
| 1ekmB02 |
|
|
|
|
|
|||||
| 1ekmC02 |
|
|
|
|
|
|||||
| 2oovA02 |
|
|
|
|
|
|||||
| 2oovB02 |
|
|
|
|
|
|||||
| 2oovC02 |
|
|
|
|
|
|||||
| 2oovD02 |
|
|
|
|
|
|||||
| 2oovE02 |
|
|
|
|
|
|||||
| 2oovF02 |
|
|
|
|
|
|||||
| 2oqeA02 |
|
|
|
|
|
|||||
| 2oqeB02 |
|
|
|
|
|
|||||
| 2oqeC02 |
|
|
|
|
|
|||||
| 2oqeD02 |
|
|
|
|
|
|||||
| 2oqeE02 |
|
|
|
|
|
|||||
| 2oqeF02 |
|
|
|
|
|
|||||
| 1av4A03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | TPQ 382 | ||
| 1avkA03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | no-modification Y382 | ||
| 1avlA03 |
|
|
|
|
|
TYR 284;ASP 298 | TPQ 382;HIS 431;HIS 433;HIS 592(Copper binding) | TPQ 382 | ||
| 1iqxA03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | TPQ 382 | ||
| 1iqxB03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | TPQ 382 | ||
| 1iqyA03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | TPQ 382 | ||
| 1iqyB03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | TPQ 382 | ||
| 1iu7A03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | TPQ 382 | ||
| 1iu7B03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | TPQ 382 | ||
| 1ivuA03 |
|
|
|
|
|
TYR 284;ASP 298 | TYR 382;HIS 431;HIS 433;HIS 592(Copper binding) | no-modification Y382 | ||
| 1ivuB03 |
|
|
|
|
|
TYR 284;ASP 298 | TYR 382;HIS 431;HIS 433;HIS 592(Copper binding) | no-modification Y382 | ||
| 1ivvA03 |
|
|
|
|
|
TYR 284;ASP 298 | DAH 382;HIS 431;HIS 433;HIS 592(Copper binding) | DAH 382 | TPQ analogue DAH382 | |
| 1ivvB03 |
|
|
|
|
|
TYR 284;ASP 298 | DAH 382;HIS 431;HIS 433;HIS 592(Copper binding) | DAH 382 | TPQ analogue DAH382 | |
| 1ivwA03 |
|
|
|
|
|
TYR 284;ASP 298 | TPQ 382;HIS 431;HIS 433;HIS 592(Copper binding) | TPQ 382 | ||
| 1ivwB03 |
|
|
|
|
|
TYR 284;ASP 298 | TPQ 382;HIS 431;HIS 433;HIS 592(Copper binding) | TPQ 382 | ||
| 1ivxA03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | TPQ 382 | ||
| 1ivxB03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | TPQ 382 | ||
| 1rjoA03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | TPQ 382 | ||
| 1sihA03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | MBQ 382 | TPQ analogue MBQ382 | |
| 1siiA03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | NBQ 382 | TPQ analogue NBQ382 | |
| 1ui7A03 |
|
|
|
|
|
TYR 284;ASP 298 | TYR 382;HIS 431;;HIS 592(Copper binding) | mutant H433A, no-modification Y382 | ||
| 1ui7B03 |
|
|
|
|
|
TYR 284;ASP 298 | TYR 382;HIS 431;;HIS 592(Copper binding) | mutant H433A, no-modification Y382 | ||
| 1ui8A03 |
|
|
|
|
|
TYR 284;ASP 298 | TPQ 382;HIS 431;HIS 433; (Copper binding) | TPQ 382 | mutant H592A | |
| 1ui8B03 |
|
|
|
|
|
TYR 284;ASP 298 | TPQ 382;HIS 431;HIS 433; (Copper binding) | TPQ 382 | mutant H592A | |
| 1w4nA03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | TCQ 382 | TPQ analogue TCQ382 | |
| 1w4nB03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | TCQ 382 | TPQ analogue TCQ382 | |
| 1w5zA03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | 3TY 382 | TPQ analogue 3TY382 | |
| 1w6cA03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | TPQ 382 | ||
| 1w6gA03 |
|
|
|
|
|
TYR 284;ASP 298 | TPQ 382;HIS 431;HIS 433;HIS 592(Copper binding) | TPQ 382 | ||
| 1wmnA03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | TPQ 382 | ||
| 1wmnB03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | TPQ 382 | ||
| 1wmoA03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | TPQ 382 | ||
| 1wmoB03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | TPQ 382 | ||
| 1wmpA03 |
|
|
|
|
|
TYR 284;ASP 298 | TYR 382;HIS 431;HIS 433;HIS 592(Copper binding) | no-modification Y382 | ||
| 1wmpB03 |
|
|
|
|
|
TYR 284;ASP 298 | TYR 382;HIS 431;HIS 433;HIS 592(Copper binding) | no-modification Y382 | ||
| 2bt3A03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | TPQ 382 | ||
| 2cfdA03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | TPQ 382 | ||
| 2cfdB03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | TPQ 382 | ||
| 2cfgA03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | TPQ 382 | ||
| 2cfgB03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | TPQ 382 | ||
| 2cfkA03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | TPQ 382 | ||
| 2cflA03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | TPQ 382 | ||
| 2cfwA03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | TPQ 382 | ||
| 2cg0A03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | TPQ 382 | ||
| 2cg1A03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | TPQ 382 | ||
| 2cwtA03 |
|
|
|
|
|
TYR 284; | ;HIS 431;HIS 433;HIS 592(Copper binding) | TPQ 382 | mutant D298A | |
| 2cwtB03 |
|
|
|
|
|
TYR 284; | ;HIS 431;HIS 433;HIS 592(Copper binding) | TPQ 382 | mutant D298A | |
| 2cwuA03 |
|
|
|
|
|
TYR 284; | ;HIS 431;HIS 433;HIS 592(Copper binding) | 1TY 382 | mutant D298A, TPQ analogue 1TY382 | |
| 2cwuB03 |
|
|
|
|
|
TYR 284; | ;HIS 431;HIS 433;HIS 592(Copper binding) | 1TY 382 | mutant D298A, TPQ analogue 1TY382 | |
| 2cwvA03 |
|
|
|
|
|
TYR 284; | ;HIS 431;HIS 433;HIS 592(Copper binding) | 2TY 382 | mutant D298A, TPQ analogue 2TY382 | |
| 2cwvB03 |
|
|
|
|
|
TYR 284; | ;HIS 431;HIS 433;HIS 592(Copper binding) | 2TY 382 | mutant D298A, TPQ analogue 2TY382 | |
| 2d1wA03 |
|
|
|
|
|
TYR 284; | ;HIS 431;HIS 433;HIS 592(Copper binding) | TTS 382 | mutant D298A, TPQ analogue TTS382 | |
| 2d1wB03 |
|
|
|
|
|
TYR 284; | ;HIS 431;HIS 433;HIS 592(Copper binding) | TTS 382 | mutant D298A, TPQ analogue TTS382 | |
| 2e2tA03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | OTY 382 | TPQ analogue OTY382 | |
| 2e2uA03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | OTY 382 | TPQ analogue OTY382 | |
| 2e2uB03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | OTY 382 | TPQ analogue OTY382 | |
| 2e2vA03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | OTY 382 | TPQ analogue OTY382 | |
| 2e2vB03 |
|
|
|
|
|
TYR 284;ASP 298 | ;HIS 431;HIS 433;HIS 592(Copper binding) | OTY 382 | TPQ analogue OTY382 | |
| 1a2vA03 |
|
|
|
|
|
TYR 305;ASP 319 | ;HIS 456;HIS 458;HIS 624(Copper binding) | TPQ 405 | ||
| 1a2vB03 |
|
|
|
|
|
TYR 305;ASP 319 | ;HIS 456;HIS 458;HIS 624(Copper binding) | TPQ 405 | ||
| 1a2vC03 |
|
|
|
|
|
TYR 305;ASP 319 | ;HIS 456;HIS 458;HIS 624(Copper binding) | TPQ 405 | ||
| 1a2vD03 |
|
|
|
|
|
TYR 305;ASP 319 | ;HIS 456;HIS 458;HIS 624(Copper binding) | TPQ 405 | ||
| 1a2vE03 |
|
|
|
|
|
TYR 305;ASP 319 | ;HIS 456;HIS 458;HIS 624(Copper binding) | TPQ 405 | ||
| 1a2vF03 |
|
|
|
|
|
TYR 305;ASP 319 | ;HIS 456;HIS 458;HIS 624(Copper binding) | TPQ 405 | ||
| 1ekmA03 |
|
|
|
|
|
TYR 305;ASP 319 | TYR 405;HIS 456;HIS 458;HIS 624(Copper binding) | no-modification Y405 | ||
| 1ekmB03 |
|
|
|
|
|
TYR 305;ASP 319 | TYR 405;HIS 456;HIS 458;HIS 624(Copper binding) | no-modification Y405 | ||
| 1ekmC03 |
|
|
|
|
|
TYR 305;ASP 319 | TYR 405;HIS 456;HIS 458;HIS 624(Copper binding) | no-modification Y405 | ||
| 2oovA03 |
|
|
|
|
|
TYR 305;ASP 319 | ;HIS 456;HIS 458;HIS 624(Copper binding) | TPQ 405 | ||
| 2oovB03 |
|
|
|
|
|
TYR 305;ASP 319 | ;HIS 456;HIS 458;HIS 624(Copper binding) | TPQ 405 | ||
| 2oovC03 |
|
|
|
|
|
TYR 305;ASP 319 | ;HIS 456;HIS 458;HIS 624(Copper binding) | TPQ 405 | ||
| 2oovD03 |
|
|
|
|
|
TYR 305;ASP 319 | ;HIS 456;HIS 458;HIS 624(Copper binding) | TPQ 405 | ||
| 2oovE03 |
|
|
|
|
|
TYR 305;ASP 319 | ;HIS 456;HIS 458;HIS 624(Copper binding) | TPQ 405 | ||
| 2oovF03 |
|
|
|
|
|
TYR 305;ASP 319 | ;HIS 456;HIS 458;HIS 624(Copper binding) | TPQ 405 | ||
| 2oqeA03 |
|
|
|
|
|
TYR 305;ASP 319 | ;HIS 456;HIS 458;HIS 624(Copper binding) | TPQ 405 | ||
| 2oqeB03 |
|
|
|
|
|
TYR 305;ASP 319 | ;HIS 456;HIS 458;HIS 624(Copper binding) | TPQ 405 | ||
| 2oqeC03 |
|
|
|
|
|
TYR 305;ASP 319 | ;HIS 456;HIS 458;HIS 624(Copper binding) | TPQ 405 | ||
| 2oqeD03 |
|
|
|
|
|
TYR 305;ASP 319 | ;HIS 456;HIS 458;HIS 624(Copper binding) | TPQ 405 | ||
| 2oqeE03 |
|
|
|
|
|
TYR 305;ASP 319 | ;HIS 456;HIS 458;HIS 624(Copper binding) | TPQ 405 | ||
| 2oqeF03 |
|
|
|
|
|
TYR 305;ASP 319 | ;HIS 456;HIS 458;HIS 624(Copper binding) | TPQ 405 | ||
| References for Catalytic Mechanism | ||
|---|---|---|
| References | Sections | No. of steps in catalysis |
|
[1]
|
Fig. 3, p.263 | |
|
[5]
|
Scheme 2, p.16121-16124, p.16131-16132 | |
|
[6]
|
Scheme 1, p.16596-16599 | |
|
[7]
|
Fig.1, p.297-298, p.303-304 | |
|
[8]
|
Scheme 2, p.3691-3693 | |
|
[9]
|
Fig.2, p.1725-1728 | |
|
[10]
|
Scheme 1, p.9713-9716 | |
|
[12]
|
Scheme 1, Scheme 2, Scheme 3, p.147-154 | |
|
[13]
|
Fig.1, Fig.7, p.15793-15796 | |
|
[14]
|
Scheme 1, Scheme 2, p.2958-2960 | |
|
[15]
|
Fig.4, Fig.5, p.668-672 | |
|
[16]
|
Scheme 1, Scheme 2, Scheme 4, p.10582-10584 | |
|
[18]
|
Scheme 1, p.3645-3646 | |
|
[20]
|
Scheme 1, Scheme 3, Scheme 4, p.1050-1055 | |
|
[22]
|
Scheme 3, p.27-30 | |
|
[24]
|
Scheme 1 | |
| References | |
|---|---|
| [1] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1846226 |
| Journal | Nature |
| Year | 1991 |
| Volume | 349 |
| Pages | 262-4 |
| Authors | Dooley DM, McGuirl MA, Brown DE, Turowski PN, McIntire WS, Knowles PF |
| Title | A Cu(I)-semiquinone state in substrate-reduced amine oxidases. |
| Related PDB | |
| Related UniProtKB | |
| [2] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7798196 |
| Journal | J Biol Chem |
| Year | 1994 |
| Volume | 269 |
| Pages | 32039-42 |
| Authors | Cai D, Klinman JP |
| Title | Evidence of a self-catalytic mechanism of 2,4,5-trihydroxyphenylalanine quinone biogenesis in yeast copper amine oxidase. |
| Related PDB | |
| Related UniProtKB | |
| [3] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8798429 |
| Journal | J Biol Chem |
| Year | 1996 |
| Volume | 271 |
| Pages | 22598-603 |
| Authors | Choi YH, Matsuzaki R, Suzuki S, Tanizawa K |
| Title |
Role of conserved Asn-Tyr-Asp-Tyr sequence in bacterial copper/2,4, |
| Related PDB | |
| Related UniProtKB | |
| [4] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | |
| Journal | Acta Crystallogr D Biol Crystallogr |
| Year | 1997 |
| Volume | 53 |
| Pages | 364-70 |
| Authors | Li R, Chen L, Cai D, Klinman JP, Mathews FS |
| Title | Crystallographic Study of Yeast Copper Amine Oxidase. |
| Related PDB | 1a2v |
| Related UniProtKB | |
| [5] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 9-628 |
| Medline ID | 98070236 |
| PubMed ID | 9405045 |
| Journal | Biochemistry |
| Year | 1997 |
| Volume | 36 |
| Pages | 16116-33 |
| Authors | Wilce MC, Dooley DM, Freeman HC, Guss JM, Matsunami H, McIntire WS, Ruggiero CE, Tanizawa K, Yamaguchi H |
| Title | Crystal structures of the copper-containing amine oxidase from Arthrobacter globiformis in the holo and apo forms: implications for the biogenesis of topaquinone. |
| Related PDB | 1av4 1avk 1avl |
| Related UniProtKB | P46881 |
| [6] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9843426 |
| Journal | Biochemistry |
| Year | 1998 |
| Volume | 37 |
| Pages | 16591-600 |
| Authors | Schwartz B, Green EL, Sanders-Loehr J, Klinman JP |
| Title | Relationship between conserved consensus site residues and the productive conformation for the TPQ cofactor in a copper-containing amine oxidase from yeast. |
| Related PDB | |
| Related UniProtKB | |
| [7] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) |
| Medline ID | 98212916 |
| PubMed ID | 9551552 |
| Journal | Structure |
| Year | 1998 |
| Volume | 6 |
| Pages | 293-307 |
| Authors | Li R, Klinman JP, Mathews FS |
| Title | Copper amine oxidase from Hansenula polymorpha: the crystal structure determined at 2.4 A resolution reveals the active conformation. |
| Related PDB | |
| Related UniProtKB | P12807 |
| [8] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10090756 |
| Journal | Biochemistry |
| Year | 1999 |
| Volume | 38 |
| Pages | 3683-93 |
| Authors | Hevel JM, Mills SA, Klinman JP |
| Title |
Mutation of a strictly conserved, |
| Related PDB | |
| Related UniProtKB | |
| [9] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) |
| Medline ID | 20045000 |
| PubMed ID | 10576737 |
| Journal | Science |
| Year | 1999 |
| Volume | 286 |
| Pages | 1724-8 |
| Authors | Wilmot CM, Hajdu J, McPherson MJ, Knowles PF, Phillips SE |
| Title | Visualization of dioxygen bound to copper during enzyme catalysis. |
| Related PDB | 1d6u 1d6y 1d6z |
| Related UniProtKB | P46883 |
| [10] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 10933787 |
| Journal | Biochemistry |
| Year | 2000 |
| Volume | 39 |
| Pages | 9709-17 |
| Authors | Chen Z, Schwartz B, Williams NK, Li R, Klinman JP, Mathews FS |
| Title | Crystal structure at 2.5 A resolution of zinc-substituted copper amine oxidase of Hansenula polymorpha expressed in Escherichia coli. |
| Related PDB | 1ekm |
| Related UniProtKB | |
| [11] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10858309 |
| Journal | Biochemistry |
| Year | 2000 |
| Volume | 39 |
| Pages | 7589-94 |
| Authors | Melville CR, Green EL, Sanders-Loehr J, Klinman JP |
| Title | Reassessment of the active site quino-cofactor proposed to occur in the Aspergillus niger amine oxidase AO-I from the properties of model compounds. |
| Related PDB | |
| Related UniProtKB | |
| [12] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11665487 |
| Journal | Adv Protein Chem |
| Year | 2001 |
| Volume | 58 |
| Pages | 141-74 |
| Authors | Dove JE, Klinman JP |
| Title | Trihydroxyphenylalanine quinone (TPQ) from copper amine oxidases and lysyl tyrosylquinone (LTQ) from lysyl oxidase. |
| Related PDB | |
| Related UniProtKB | |
| [13] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11747456 |
| Journal | Biochemistry |
| Year | 2001 |
| Volume | 40 |
| Pages | 15789-96 |
| Authors | Hirota S, Iwamoto T, Kishishita S, Okajima T, Yamauchi O, Tanizawa K |
| Title | Spectroscopic observation of intermediates formed during the oxidative half-reaction of copper/topa quinone-containing phenylethylamine oxidase. |
| Related PDB | |
| Related UniProtKB | |
| [14] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11258907 |
| Journal | Biochemistry |
| Year | 2001 |
| Volume | 40 |
| Pages | 2954-63 |
| Authors | Schwartz B, Olgin AK, Klinman JP |
| Title |
The role of copper in topa quinone biogenesis and catalysis, |
| Related PDB | |
| Related UniProtKB | |
| [15] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11751046 |
| Journal | Curr Opin Struct Biol |
| Year | 2001 |
| Volume | 11 |
| Pages | 666-73 |
| Authors | Dawkes HC, Phillips SE |
| Title | Copper amine oxidase: cunning cofactor and controversial copper. |
| Related PDB | |
| Related UniProtKB | |
| [16] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12186541 |
| Journal | Biochemistry |
| Year | 2002 |
| Volume | 41 |
| Pages | 10577-84 |
| Authors | Mills SA, Goto Y, Su Q, Plastino J, Klinman JP |
| Title | Mechanistic comparison of the cobalt-substituted and wild-type copper amine oxidase from Hansenula polymorpha. |
| Related PDB | |
| Related UniProtKB | |
| [17] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12427025 |
| Journal | Biochemistry |
| Year | 2002 |
| Volume | 41 |
| Pages | 13637-43 |
| Authors | Goto Y, Klinman JP |
| Title | Binding of dioxygen to non-metal sites in proteins: exploration of the importance of binding site size versus hydrophobicity in the copper amine oxidase from Hansenula polymorpha. |
| Related PDB | |
| Related UniProtKB | |
| [18] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12153561 |
| Journal | Eur J Biochem |
| Year | 2002 |
| Volume | 269 |
| Pages | 3645-58 |
| Authors | Shepard EM, Smith J, Elmore BO, Kuchar JA, Sayre LM, Dooley DM |
| Title |
Towards the development of selective amine oxidase inhibitors. |
| Related PDB | |
| Related UniProtKB | |
| [19] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 12134140 |
| Journal | Nat Struct Biol |
| Year | 2002 |
| Volume | 9 |
| Pages | 591-6 |
| Authors | Kim M, Okajima T, Kishishita S, Yoshimura M, Kawamori A, Tanizawa K, Yamaguchi H |
| Title | X-ray snapshots of quinone cofactor biogenesis in bacterial copper amine oxidase. |
| Related PDB | 1ivu 1ivv 1ivw 1ivx |
| Related UniProtKB | |
| [20] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 12537504 |
| Journal | J Am Chem Soc |
| Year | 2003 |
| Volume | 125 |
| Pages | 1041-55 |
| Authors | Kishishita S, Okajima T, Kim M, Yamaguchi H, Hirota S, Suzuki S, Kuroda S, Tanizawa K, Mure M |
| Title | Role of copper ion in bacterial copper amine oxidase: spectroscopic and crystallographic studies of metal-substituted enzymes. |
| Related PDB | 1iqx 1iqy 1iu7 |
| Related UniProtKB | |
| [21] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12673620 |
| Journal | Yeast |
| Year | 2003 |
| Volume | 20 |
| Pages | 369-79 |
| Authors | Corpillo D, Valetti F, Giuffrida MG, Conti A, Rossi A, Finazzi-Agro A, Giunta C |
| Title | Induction and characterization of a novel amine oxidase from the yeast Kluyveromyces marxianus. |
| Related PDB | |
| Related UniProtKB | |
| [22] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 15234266 |
| Journal | Arch Biochem Biophys |
| Year | 2004 |
| Volume | 428 |
| Pages | 22-31 |
| Authors | Brazeau BJ, Johnson BJ, Wilmot CM |
| Title |
Copper-containing amine oxidases. |
| Related PDB | |
| Related UniProtKB | |
| [23] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 14979714 |
| Journal | Biochemistry |
| Year | 2004 |
| Volume | 43 |
| Pages | 2178-87 |
| Authors | Matsunami H, Okajima T, Hirota S, Yamaguchi H, Hori H, Kuroda S, Tanizawa K |
| Title | Chemical rescue of a site-specific mutant of bacterial copper amine oxidase for generation of the topa quinone cofactor. |
| Related PDB | 1ui7 1ui8 |
| Related UniProtKB | |
| [24] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 15323556 |
| Journal | Biochemistry |
| Year | 2004 |
| Volume | 43 |
| Pages | 10965-78 |
| Authors | O'Connell KM, Langley DB, Shepard EM, Duff AP, Jeon HB, Sun G, Freeman HC, Guss JM, Sayre LM, Dooley DM |
| Title | Differential inhibition of six copper amine oxidases by a family of 4-(aryloxy)-2-butynamines: evidence for a new mode of inactivation. |
| Related PDB | 1sih 1sii |
| Related UniProtKB | |
| [25] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 15038754 |
| Journal | J Am Chem Soc |
| Year | 2004 |
| Volume | 126 |
| Pages | 3996-4006 |
| Authors | Prabhakar R, Siegbahn PE |
| Title | A theoretical study of the mechanism for the biogenesis of cofactor topaquinone in copper amine oxidases. |
| Related PDB | |
| Related UniProtKB | |
| [26] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 15533431 |
| Journal | J Mol Biol |
| Year | 2004 |
| Volume | 344 |
| Pages | 599-607 |
| Authors | Duff AP, Trambaiolo DM, Cohen AE, Ellis PJ, Juda GA, Shepard EM, Langley DB, Dooley DM, Freeman HC, Guss JM |
| Title | Using xenon as a probe for dioxygen-binding sites in copper amine oxidases. |
| Related PDB | 1w2z 1rjo 1rky |
| Related UniProtKB | |
| [27] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 16157884 |
| Journal | Proc Natl Acad Sci U S A |
| Year | 2005 |
| Volume | 102 |
| Pages | 13451-6 |
| Authors | Contakes SM, Juda GA, Langley DB, Halpern-Manners NW, Duff AP, Dunn AR, Gray HB, Dooley DM, Guss JM, Freeman HC |
| Title | Reversible inhibition of copper amine oxidase activity by channel-blocking ruthenium(II) and rhenium(I) molecular wires. |
| Related PDB | 2bt3 |
| Related UniProtKB | |
| [28] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 16142901 |
| Journal | Biochemistry |
| Year | 2005 |
| Volume | 44 |
| Pages | 12041-8 |
| Authors | Okajima T, Kishishita S, Chiu YC, Murakawa T, Kim M, Yamaguchi H, Hirota S, Kuroda S, Tanizawa K |
| Title | Reinvestigation of metal ion specificity for quinone cofactor biogenesis in bacterial copper amine oxidase. |
| Related PDB | 1wmn 1wmo |
| Related UniProtKB | |
| [29] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 17077478 |
| Journal | Acta Crystallogr Sect F Struct Biol Cryst Commun |
| Year | 2006 |
| Volume | 62 |
| Pages | 1052-7 |
| Authors | Langley DB, Duff AP, Freeman HC, Guss JM |
| Title | The copper-containing amine oxidase from Arthrobacter globiformis: refinement at 1.55 and 2.20 A resolution in two crystal forms. |
| Related PDB | |
| Related UniProtKB | |
| [30] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 16566584 |
| Journal | Biochemistry |
| Year | 2006 |
| Volume | 45 |
| Pages | 4105-20 |
| Authors | Chiu YC, Okajima T, Murakawa T, Uchida M, Taki M, Hirota S, Kim M, Yamaguchi H, Kawano Y, Kamiya N, Kuroda S, Hayashi H, Yamamoto Y, Tanizawa K |
| Title | Kinetic and structural studies on the catalytic role of the aspartic acid residue conserved in copper amine oxidase. |
| Related PDB | 2cwt 2cwu 2cwv |
| Related UniProtKB | |
| [31] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 16487484 |
| Journal | Biochem Biophys Res Commun |
| Year | 2006 |
| Volume | 342 |
| Pages | 414-23 |
| Authors | Murakawa T, Okajima T, Kuroda S, Nakamoto T, Taki M, Yamamoto Y, Hayashi H, Tanizawa K |
| Title | Quantum mechanical hydrogen tunneling in bacterial copper amine oxidase reaction. |
| Related PDB | 2d1w |
| Related UniProtKB | |
| [32] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 17409383 |
| Journal | J Biol Chem |
| Year | 2007 |
| Volume | 282 |
| Pages | 17767-76 |
| Authors | Johnson BJ, Cohen J, Welford RW, Pearson AR, Schulten K, Klinman JP, Wilmot CM |
| Title | Exploring molecular oxygen pathways in Hansenula polymorpha copper-containing amine oxidase. |
| Related PDB | 2oov 2oqe |
| Related UniProtKB | |
| Comments |
|---|
|
The catalytic domain of this enzyme is homologous to those of counterpart enzymes from E. Cofactor, According to the literature [24], (I) Reductive half-reaction: (A) Exchange of double-bonded atoms; Schiff-base formation; Substrate amine forms a Schiff-base with topaquinone, (B) Isomerization from iminoquinone=substrate complex to aminoquinol=product complex (through a carbanionic intermediate): (C) Exchange of double-bonded atoms; Schiff-base deformation; H2O reacts with the intermediate, (II) Oxidative half-reaction: (D) Reduction of dioxygen (O2) by aminoquinol, (E) Exchange of double-bonded atoms; Schiff-base deformation; H2O reacts with the intermediate, |
| Created | Updated |
|---|---|
| 2005-05-26 | 2009-03-04 |