DB code: M00103
CATH domain | 3.30.457.10 : Copper Amine Oxidase; Chain A, domain 1 | |
---|---|---|
3.10.450.40 : Nuclear Transport Factor 2; Chain | ||
2.70.98.20 : Beta-galactosidase; Chain A, domain 5 | Catalytic domain | |
3.10.450.40 : Nuclear Transport Factor 2; Chain | ||
E.C. | 1.4.3.21 | |
CSA | 1oac | |
M-CSA | 1oac | |
MACiE |
CATH domain | Related DB codes (homologues) |
---|---|
2.70.98.20 : Beta-galactosidase; Chain A, domain 5 | M00202 T00206 T00250 T00251 |
3.10.450.40 : Nuclear Transport Factor 2; Chain | M00202 T00206 T00250 T00251 |
Uniprot Enzyme Name | UniprotKB | Protein name | Synonyms | RefSeq | Pfam |
---|---|---|---|---|
P46883 |
Primary amine oxidase
|
EC
1.4.3.21
Copper amine oxidase Tyramine oxidase 2-phenylethylamine oxidase |
NP_415904.3
(Protein)
NC_000913.2 (DNA/RNA sequence) YP_489655.1 (Protein) NC_007779.1 (DNA/RNA sequence) |
PF01179
(Cu_amine_oxid)
PF07833 (Cu_amine_oxidN1) PF02727 (Cu_amine_oxidN2) PF02728 (Cu_amine_oxidN3) [Graphical View] |
KEGG enzyme name |
---|
primary-amine oxidase
amine oxidase (ambiguous) amine oxidase (copper-containing) amine oxidase (pyridoxal containing) (incorrect) benzylamine oxidase (incorrect) CAO (ambiguous) copper amine oxidase (ambiguous) Cu-amine oxidase (ambiguous) Cu-containing amine oxidase (ambiguous) diamine oxidase (incorrect) diamino oxhydrase (incorrect) histamine deaminase (ambiguous) histamine oxidase (ambiguous) monoamine oxidase (ambiguous) plasma monoamine oxidase (ambiguous) polyamine oxidase (ambiguous) semicarbazide-sensitive amine oxidase (ambiguous) SSAO (ambiguous) |
UniprotKB: Accession Number | Entry name | Activity | Subunit | Subcellular location | Cofactor |
---|---|---|---|---|---|
P46883 | AMO_ECOLI | RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2). 2-phenylethylamine + H(2)O + O(2) = phenylacetaldehyde + NH(3) + H(2)O(2). | Homodimer. | Periplasm. | Binds 1 copper ion per subunit. Binds 2 calcium ions per subunit. Contains 1 topaquinone per subunit. |
KEGG Pathways | Map code | Pathways | E.C. |
---|---|---|
MAP00260 | Glycine, serine and threonine metabolism | |
MAP00350 | Tyrosine metabolism | |
MAP00360 | Phenylalanine metabolism | |
MAP00410 | beta-Alanine metabolism | |
MAP00960 | Alkaloid biosynthesis II |
Compound table | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cofactors | Substrates | Products | Intermediates | ||||||||||||||||
KEGG-id | C00070 | C00076 | L00003 | C00375 | C00001 | C00007 | C00071 | C00014 | C00027 | I00021 | I00022 | I00023 | I00024 | ||||||
E.C. | |||||||||||||||||||
Compound | Copper | Calcium | Topaquinone | RCH2NH2 | H2O | Oxygen | Aldehyde | NH3 | H2O2 | Substrate Schiff-base (Iminoquinone=substrate) | Carbanionic intermediate | Product Schiff-base (Aminoquinol=product) | Aminoquinol/Semiquinone | Iminoquinone | |||||
Type | heavy metal | divalent metal (Ca2+, Mg2+) | amino acids,aromatic ring (only carbon atom) | amine group | H2O | others | carbohydrate | amine group,organic ion | others | ||||||||||
ChEBI |
28694 30052 28694 30052 |
29108 29108 |
36077 68431 36077 68431 |
15377 15377 |
15379 26689 27140 15379 26689 27140 |
16134 16134 |
16240 16240 |
||||||||||||
PubChem |
23978 23978 |
271 271 |
22247451 962 22247451 962 |
977 977 |
222 222 |
22326046 784 22326046 784 |
|||||||||||||
1d6uA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1d6uB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1d6yA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1d6yB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1d6zA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1d6zB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1jrqA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1jrqB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1lvnA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1lvnB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1oacA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1oacB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1spuA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1spuB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1dyuA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1dyuB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1qafA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1qafB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1qakA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1qakB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1qalA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1qalB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1d6uA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1d6uB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1d6yA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1d6yB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1d6zA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1d6zB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1jrqA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1jrqB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1lvnA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1lvnB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1oacA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1oacB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1spuA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1spuB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1dyuA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1dyuB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1qafA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1qafB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1qakA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1qakB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1qalA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1qalB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1d6uA03 |
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Bound:_CU | Bound:2x_CA | Analogue:TYQ_466 | Unbound | Unbound | Bound:HY1 | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-bound:TYQ_466 | Unbound | |
1d6uB03 |
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Bound:_CU | Bound:2x_CA | Analogue:TYQ_466 | Unbound | Unbound | Bound:HY1 | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-bound:TYQ_466 | Unbound | |
1d6yA03 |
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Bound:_CU | Bound:2x_CA | Analogue:TYQ_466 | Unbound | Analogue:_NO | Bound:HY1 | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-bound:TYQ_466 | Unbound | |
1d6yB03 |
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Bound:_CU | Bound:2x_CA | Analogue:TYQ_466 | Unbound | Analogue:_NO | Bound:HY1 | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-bound:TYQ_466 | Unbound | |
1d6zA03 |
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Bound:_CU | Bound:2x_CA | Analogue:TYY_466 | Unbound | Unbound | Bound:HY1 | Unbound | Bound:PEO | Unbound | Unbound | Unbound | Unbound | Intermediate-bound:TYY_466 | |
1d6zB03 |
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Bound:_CU | Bound:2x_CA | Analogue:TYY_466 | Unbound | Unbound | Bound:HY1 | Unbound | Bound:PEO | Unbound | Unbound | Unbound | Unbound | Intermediate-bound:TYY_466 | |
1jrqA03 |
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Bound:_CU | Bound:2x_CA | Bound:TPQ_466 | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1jrqB03 |
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Bound:_CU | Bound:2x_CA | Bound:TPQ_466 | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1lvnA03 |
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Bound:_CU | Bound:2x_CA | Analogue:TYT_466 | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:TYT_466 | Unbound | Unbound | Unbound | Unbound | |
1lvnB03 |
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Bound:_CU | Bound:2x_CA | Analogue:TYT_466 | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:TYT_466 | Unbound | Unbound | Unbound | Unbound | |
1oacA03 |
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Bound:_CU | Bound:2x_CA | Bound:TPQ_466 | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1oacB03 |
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Bound:_CU | Bound:2x_CA | Bound:TPQ_466 | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1spuA03 |
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Bound:_CU | Bound:2x_CA | Analogue:PAQ_466 | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:PAQ_466 | Unbound | Unbound | Unbound | Unbound | |
1spuB03 |
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Bound:_CU | Bound:2x_CA | Analogue:PAQ_466 | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:PAQ_466 | Unbound | Unbound | Unbound | Unbound | |
1dyuA03 |
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Bound:_CU | Bound:2x_CA | Bound:TPQ_466 | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1dyuB03 |
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Bound:_CU | Bound:2x_CA | Bound:TPQ_466 | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1qafA03 |
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Bound:_CU | Bound:2x_CA | Bound:TPQ_466 | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1qafB03 |
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Bound:_CU | Bound:2x_CA | Bound:TPQ_466 | Analogue:GOL | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1qakA03 |
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Bound:_CU | Bound:2x_CA | Bound:TPQ_466 | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1qakB03 |
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Bound:_CU | Bound:2x_CA | Bound:TPQ_466 | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1qalA03 |
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Bound:_CU | Bound:2x_CA | Bound:TPQ_466 | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1qalB03 |
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Bound:_CU | Bound:2x_CA | Bound:TPQ_466 | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1d6uA04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1d6uB04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1d6yA04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1d6yB04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1d6zA04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1d6zB04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1jrqA04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1jrqB04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1lvnA04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1lvnB04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1oacA04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1oacB04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1spuA04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1spuB04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1dyuA04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1dyuB04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1qafA04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1qafB04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1qakA04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1qakB04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1qalA04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
1qalB04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
Reference for Active-site residues | ||
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resource | references | E.C. |
Active-site residues | ||||||||||
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PDB | Catalytic residues | Cofactor-binding residues | Modified residues | Main-chain involved in catalysis | Comment | |||||
1d6uA01 |
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1d6uB01 |
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1d6yA01 |
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1d6yB01 |
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1d6zA01 |
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1d6zB01 |
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1jrqA01 |
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1jrqB01 |
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1lvnA01 |
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1lvnB01 |
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1oacA01 |
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1oacB01 |
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1spuA01 |
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1spuB01 |
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1dyuA01 |
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1dyuB01 |
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1qafA01 |
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1qafB01 |
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1qakA01 |
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1qakB01 |
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1qalA01 |
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1qalB01 |
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1d6uA02 |
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1d6uB02 |
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1d6yA02 |
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1d6yB02 |
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1d6zA02 |
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1d6zB02 |
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1jrqA02 |
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1jrqB02 |
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1lvnA02 |
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1lvnB02 |
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1oacA02 |
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1oacB02 |
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1spuA02 |
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1spuB02 |
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1dyuA02 |
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1dyuB02 |
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1qafA02 |
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1qafB02 |
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1qakA02 |
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1qakB02 |
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1qalA02 |
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1qalB02 |
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1d6uA03 |
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TYR 369;ASP 383 | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TYQ 466(aminoquinol) | ||
1d6uB03 |
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TYR 369;ASP 383 | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TYQ 466(aminoquinol) | ||
1d6yA03 |
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TYR 369;ASP 383 | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TYQ 466(aminoquinol) | ||
1d6yB03 |
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TYR 369;ASP 383 | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TYQ 466(aminoquinol) | ||
1d6zA03 |
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TYR 369;ASP 383 | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TYY 466(iminoquinone) | ||
1d6zB03 |
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TYR 369;ASP 383 | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TYY 466(iminoquinone) | ||
1jrqA03 |
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;ASP 383 | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TPQ 466(topaquinone) | mutant Y369F | |
1jrqB03 |
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;ASP 383 | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TPQ 466(topaquinone) | mutant Y369F | |
1lvnA03 |
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TYR 369;ASP 383 | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TYT 466(iminoquinone-substrate analogue) | ||
1lvnB03 |
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TYR 369;ASP 383 | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TYT 466(iminoquinone-substrate analogue) | ||
1oacA03 |
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TYR 369;ASP 383 | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TPQ 466(topaquinone) | ||
1oacB03 |
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TYR 369;ASP 383 | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TPQ 466(topaquinone) | ||
1spuA03 |
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TYR 369;ASP 383 | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | PAQ 466(2-oxy-4-hydroxy-5-(2-hydrazinopyridine)phenylalanine) | ||
1spuB03 |
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TYR 369;ASP 383 | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | PAQ 466(2-oxy-4-hydroxy-5-(2-hydrazinopyridine)phenylalanine) | ||
1dyuA03 |
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TYR 369;ASP 383 | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TYR 466(topaquinone) | ||
1dyuB03 |
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TYR 369;ASP 383 | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TYR 466(topaquinone) | ||
1qafA03 |
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TYR 369; | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TPQ 466(topaquinone) | mutant D383E | |
1qafB03 |
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TYR 369; | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TPQ 466(topaquinone) | mutant D383E | |
1qakA03 |
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TYR 369; | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TPQ 466(topaquinone) | mutant D383A | |
1qakB03 |
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TYR 369; | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TPQ 466(topaquinone) | mutant D383A | |
1qalA03 |
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TYR 369; | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TPQ 466(topaquinone) | mutant D383N | |
1qalB03 |
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TYR 369; | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TPQ 466(topaquinone) | mutant D383N | |
1d6uA04 |
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1d6uB04 |
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1d6yA04 |
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1d6yB04 |
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1d6zA04 |
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1d6zB04 |
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1jrqA04 |
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1jrqB04 |
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1lvnA04 |
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1lvnB04 |
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1oacA04 |
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1oacB04 |
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1spuA04 |
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1spuB04 |
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1dyuA04 |
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1dyuB04 |
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1qafA04 |
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1qafB04 |
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1qakA04 |
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1qakB04 |
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1qalA04 |
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1qalB04 |
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References for Catalytic Mechanism | ||
---|---|---|
References | Sections | No. of steps in catalysis |
[5]
|
Scheme II, p.60-62 | |
[6]
|
Fig. 1, p.1128-1129 | |
[7]
|
Fig.1, p.1178-1179 | |
[9]
|
Scheme 1, p.5586-5588 | |
[10]
|
Fig.2, Fig.10, p.1617-1619 | |
[11]
|
Scheme 23, Scheme 24, p.746-747 | |
[12]
|
Fig.1, p.8224-8226 | |
[13]
|
Fig.2, p.1725-1728 | |
[15]
|
Fig.2, p.12814-12817 | |
[17]
|
Scheme 1, Fig.1, p.4694-4605 | |
[18]
|
Scheme 1, p.814-815 | |
[21]
|
Fig.4, Fig.6, p.313-315 | |
[22]
|
Scheme 1, Fig.1, p.494-496 | |
[23]
|
Scheme 2 |
References | |
---|---|
[1] | |
Resource | |
Comments | |
Medline ID | |
PubMed ID | 8155661 |
Journal | Biochemistry |
Year | 1994 |
Volume | 33 |
Pages | 4425-31 |
Authors | Bossa M, Morpurgo GO, Morpurgo L |
Title | Models and molecular orbital semiempirical calculations in the study of the spectroscopic properties of bovine serum amine oxidase quinone cofactor. |
Related PDB | |
Related UniProtKB | |
[2] | |
Resource | |
Comments | |
Medline ID | |
PubMed ID | 8176752 |
Journal | J Mol Biol |
Year | 1994 |
Volume | 238 |
Pages | 635-7 |
Authors | Roh JH, Suzuki H, Kumagai H, Yamashita M, Azakami H, Murooka Y, Mikami B |
Title | Crystallization and preliminary X-ray analysis of copper amine oxidase from Escherichia coli K-12. |
Related PDB | |
Related UniProtKB | |
[3] | |
Resource | |
Comments | |
Medline ID | |
PubMed ID | 8585612 |
Journal | Anal Biochem |
Year | 1995 |
Volume | 230 |
Pages | 159-66 |
Authors | Steinebach V, Groen BW, Wijmenga SS, Niessen WM, Jongejan JA, Duine JA |
Title |
Identification of topaquinone, |
Related PDB | |
Related UniProtKB | |
[4] | |
Resource | |
Comments | |
Medline ID | |
PubMed ID | 7766611 |
Journal | Biochemistry |
Year | 1995 |
Volume | 34 |
Pages | 7020-6 |
Authors | Moenne-Loccoz P, Nakamura N, Steinebach V, Duine JA, Mure M, Klinman JP, Sanders-Loehr J |
Title | Characterization of the topa quinone cofactor in amine oxidase from Escherichia coli by resonance Raman spectroscopy. |
Related PDB | |
Related UniProtKB | |
[5] | |
Resource | |
Comments | |
Medline ID | |
PubMed ID | 8524164 |
Journal | Methods Enzymol |
Year | 1995 |
Volume | 258 |
Pages | 53-69 |
Authors | Sayre LM, Lee Y |
Title | Catalytic aerobic deamination of activated primary amines by a model for the quinone cofactor of mammalian copper amine oxidases. |
Related PDB | |
Related UniProtKB | |
[6] | |
Resource | |
Comments | |
Medline ID | |
PubMed ID | 8591022 |
Journal | Structure |
Year | 1995 |
Volume | 3 |
Pages | 1127-9 |
Authors | Fontecave M, Eklund H |
Title | Copper amine oxidase: a novel use for a tyrosine. |
Related PDB | |
Related UniProtKB | |
[7] | |
Resource | |
Comments | X-ray crystallography |
Medline ID | |
PubMed ID | 8591028 |
Journal | Structure |
Year | 1995 |
Volume | 3 |
Pages | 1171-84 |
Authors | Parsons MR, Convery MA, Wilmot CM, Yadav KD, Blakeley V, Corner AS, Phillips SE, McPherson MJ, Knowles PF |
Title | Crystal structure of a quinoenzyme: copper amine oxidase of Escherichia coli at 2 A resolution. |
Related PDB | 1oac |
Related UniProtKB | |
[8] | |
Resource | |
Comments | |
Medline ID | |
PubMed ID | 8706668 |
Journal | Eur J Biochem |
Year | 1996 |
Volume | 238 |
Pages | 683-9 |
Authors | Steinebach V, De Jong GA, Wijmenga SS, De Vries S, Duine JA |
Title | The copper-topaquinone-phenylhydrazine-adduct geometry in Escherichia coli amine oxidase derivatized with phenylhydrazines substituted with 19F-NMR relaxation measurements. |
Related PDB | |
Related UniProtKB | |
[9] | |
Resource | |
Comments | |
Medline ID | |
PubMed ID | 8621418 |
Journal | J Biol Chem |
Year | 1996 |
Volume | 271 |
Pages | 5580-8 |
Authors | Steinebach V, de Vries S, Duine JA |
Title | Intermediates in the catalytic cycle of copper-quinoprotein amine oxidase from Escherichia coli. |
Related PDB | |
Related UniProtKB | |
[10] | |
Resource | |
Comments | X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) |
Medline ID | 97200715 |
PubMed ID | 9048544 |
Journal | Biochemistry |
Year | 1997 |
Volume | 36 |
Pages | 1608-20 |
Authors | Wilmot CM, Murray JM, Alton G, Parsons MR, Convery MA, Blakeley V, Corner AS, Palcic MM, Knowles PF, McPherson MJ, Phillips SE |
Title | Catalytic mechanism of the quinoenzyme amine oxidase from Escherichia coli: exploring the reductive half-reaction. |
Related PDB | 1spu |
Related UniProtKB | P46883 |
[11] | |
Resource | |
Comments | |
Medline ID | |
PubMed ID | 11848913 |
Journal | Chem Rev |
Year | 1998 |
Volume | 98 |
Pages | 705-762 |
Authors | Stubbe J, van Der Donk WA |
Title | Protein Radicals in Enzyme Catalysis. |
Related PDB | |
Related UniProtKB | |
[12] | |
Resource | |
Comments | X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) |
Medline ID | 99315198 |
PubMed ID | 10387067 |
Journal | Biochemistry |
Year | 1999 |
Volume | 38 |
Pages | 8217-27 |
Authors | Murray JM, Saysell CG, Wilmot CM, Tambyrajah WS, Jaeger J, Knowles PF, Phillips SE, McPherson MJ |
Title | The active site base controls cofactor reactivity in Escherichia coli amine oxidase: x-ray crystallographic studies with mutational variants. |
Related PDB | |
Related UniProtKB | P46883 |
[13] | |
Resource | |
Comments | X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) |
Medline ID | 20045000 |
PubMed ID | 10576737 |
Journal | Science |
Year | 1999 |
Volume | 286 |
Pages | 1724-8 |
Authors | Wilmot CM, Hajdu J, McPherson MJ, Knowles PF, Phillips SE |
Title | Visualization of dioxygen bound to copper during enzyme catalysis. |
Related PDB | 1d6u 1d6y 1d6z |
Related UniProtKB | P46883 |
[14] | |
Resource | |
Comments | |
Medline ID | |
PubMed ID | 11665487 |
Journal | Adv Protein Chem |
Year | 2001 |
Volume | 58 |
Pages | 141-74 |
Authors | Dove JE, Klinman JP |
Title | Trihydroxyphenylalanine quinone (TPQ) from copper amine oxidases and lysyl tyrosylquinone (LTQ) from lysyl oxidase. |
Related PDB | |
Related UniProtKB | |
[15] | |
Resource | |
Comments | |
Medline ID | |
PubMed ID | 11669617 |
Journal | Biochemistry |
Year | 2001 |
Volume | 40 |
Pages | 12808-18 |
Authors | Murray JM, Kurtis CR, Tambyrajah W, Saysell CG, Wilmot CM, Parsons MR, Phillips SE, Knowles PF, McPherson MJ |
Title | Conserved tyrosine-369 in the active site of Escherichia coli copper amine oxidase is not essential. |
Related PDB | 1jrq |
Related UniProtKB | |
[16] | |
Resource | |
Comments | |
Medline ID | |
PubMed ID | 11751046 |
Journal | Curr Opin Struct Biol |
Year | 2001 |
Volume | 11 |
Pages | 666-73 |
Authors | Dawkes HC, Phillips SE |
Title | Copper amine oxidase: cunning cofactor and controversial copper. |
Related PDB | |
Related UniProtKB | |
[17] | |
Resource | |
Comments | |
Medline ID | |
PubMed ID | 11532005 |
Journal | Eur J Biochem |
Year | 2001 |
Volume | 268 |
Pages | 4686-97 |
Authors | Padiglia A, Medda R, Lorrai A, Paci M, Pedersen JZ, Boffi A, Bellelli A, Agro AF, Floris G |
Title | Irreversible inhibition of pig kidney copper-containing amine oxidase by sodium and lithium ions. |
Related PDB | |
Related UniProtKB | |
[18] | |
Resource | |
Comments | |
Medline ID | |
PubMed ID | 11985492 |
Journal | Biochem J |
Year | 2002 |
Volume | 365 |
Pages | 809-16 |
Authors | Saysell CG, Tambyrajah WS, Murray JM, Wilmot CM, Phillips SE, McPherson MJ, Knowles PF |
Title | Probing the catalytic mechanism of Escherichia coli amine oxidase using mutational variants and a reversible inhibitor as a substrate analogue. |
Related PDB | |
Related UniProtKB | |
[19] | |
Resource | |
Comments | |
Medline ID | |
PubMed ID | 11781110 |
Journal | Biochemistry |
Year | 2002 |
Volume | 41 |
Pages | 687-96 |
Authors | Green EL, Nakamura N, Dooley DM, Klinman JP, Sanders-Loehr J |
Title | Rates of oxygen and hydrogen exchange as indicators of TPQ cofactor orientation in amine oxidases. |
Related PDB | |
Related UniProtKB | |
[20] | |
Resource | |
Comments | |
Medline ID | |
PubMed ID | 12153561 |
Journal | Eur J Biochem |
Year | 2002 |
Volume | 269 |
Pages | 3645-58 |
Authors | Shepard EM, Smith J, Elmore BO, Kuchar JA, Sayre LM, Dooley DM |
Title |
Towards the development of selective amine oxidase inhibitors. |
Related PDB | |
Related UniProtKB | |
[21] | |
Resource | |
Comments | |
Medline ID | |
PubMed ID | 12078505 |
Journal | Methods Enzymol |
Year | 2002 |
Volume | 353 |
Pages | 301-18 |
Authors | Wilmot CM, Sjogren T, Carlsson GH, Berglund GI, Hajdu J |
Title | Defining redox state of X-ray crystal structures by single-crystal ultraviolet-visible microspectrophotometry. |
Related PDB | |
Related UniProtKB | |
[22] | |
Resource | |
Comments | |
Medline ID | |
PubMed ID | 12773142 |
Journal | Biochem Soc Trans |
Year | 2003 |
Volume | 31 |
Pages | 493-6 |
Authors | Wilmot CM |
Title | Oxygen activation in a copper-containing amine oxidase. |
Related PDB | |
Related UniProtKB | |
[23] | |
Resource | |
Comments | |
Medline ID | |
PubMed ID | 15234266 |
Journal | Arch Biochem Biophys |
Year | 2004 |
Volume | 428 |
Pages | 22-31 |
Authors | Brazeau BJ, Johnson BJ, Wilmot CM |
Title |
Copper-containing amine oxidases. |
Related PDB | |
Related UniProtKB | |
[24] | |
Resource | |
Comments | |
Medline ID | |
PubMed ID | 15498552 |
Journal | FEBS Lett |
Year | 2004 |
Volume | 576 |
Pages | 301-5 |
Authors | Wilmot CM, Saysell CG, Blessington A, Conn DA, Kurtis CR, McPherson MJ, Knowles PF, Phillips SE |
Title | Medical implications from the crystal structure of a copper-containing amine oxidase complexed with the antidepressant drug tranylcypromine. |
Related PDB | 1lvn |
Related UniProtKB | |
[25] | |
Resource | |
Comments | |
Medline ID | |
PubMed ID | 15369390 |
Journal | J Med Chem |
Year | 2004 |
Volume | 47 |
Pages | 4865-74 |
Authors | Marti L, Abella A, De La Cruz X, Garcia-Vicente S, Unzeta M, Carpene C, Palacin M, Testar X, Orozco M, Zorzano A |
Title | Exploring the binding mode of semicarbazide-sensitive amine oxidase/VAP-1: identification of novel substrates with insulin-like activity. |
Related PDB | |
Related UniProtKB |
Comments |
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Cofactor, Although this enzyme binds a copper ion and two calcium ions as cofactors per subunit, The following compounds can be inculded as substrate and product, Phenethylamine;C05332 Phenylacetaldehyde;C00601 According to the literature [13], (I) Reductive half-reaction: (A) Exchange of double-bonded atoms; Schiff-base formation; Substrate amine forms a Schiff-base with topaquinone, (B) Isomerization from iminoquinone=substrate complex to aminoquinol=product complex: (C) Exchange of double-bonded atoms; Schiff-base deformation; H2O reacts with the intermediate, (II) Oxidative half-reaction: (D) Reduction of dioxygen (O2) by aminoquinol, (E) Exchange of double-bonded atoms; Schiff-base deformation; H2O reacts with the intermediate, |
Created | Updated |
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2005-05-26 | 2009-02-26 |