DB code: M00103
| CATH domain | 3.30.457.10 : Copper Amine Oxidase; Chain A, domain 1 | |
|---|---|---|
| 3.10.450.40 : Nuclear Transport Factor 2; Chain | ||
| 2.70.98.20 : Beta-galactosidase; Chain A, domain 5 | Catalytic domain | |
| 3.10.450.40 : Nuclear Transport Factor 2; Chain | ||
| E.C. | 1.4.3.21 | |
| CSA | 1oac | |
| M-CSA | 1oac | |
| MACiE | ||
| CATH domain | Related DB codes (homologues) |
|---|---|
| 2.70.98.20 : Beta-galactosidase; Chain A, domain 5 | M00202 T00206 T00250 T00251 |
| 3.10.450.40 : Nuclear Transport Factor 2; Chain | M00202 T00206 T00250 T00251 |
| Uniprot Enzyme Name | UniprotKB | Protein name | Synonyms | RefSeq | Pfam |
|---|---|---|---|---|
| P46883 |
Primary amine oxidase
|
EC
1.4.3.21
Copper amine oxidase Tyramine oxidase 2-phenylethylamine oxidase |
NP_415904.3
(Protein)
NC_000913.2 (DNA/RNA sequence) YP_489655.1 (Protein) NC_007779.1 (DNA/RNA sequence) |
PF01179
(Cu_amine_oxid)
PF07833 (Cu_amine_oxidN1) PF02727 (Cu_amine_oxidN2) PF02728 (Cu_amine_oxidN3) [Graphical View] |
| KEGG enzyme name |
|---|
|
primary-amine oxidase
amine oxidase (ambiguous) amine oxidase (copper-containing) amine oxidase (pyridoxal containing) (incorrect) benzylamine oxidase (incorrect) CAO (ambiguous) copper amine oxidase (ambiguous) Cu-amine oxidase (ambiguous) Cu-containing amine oxidase (ambiguous) diamine oxidase (incorrect) diamino oxhydrase (incorrect) histamine deaminase (ambiguous) histamine oxidase (ambiguous) monoamine oxidase (ambiguous) plasma monoamine oxidase (ambiguous) polyamine oxidase (ambiguous) semicarbazide-sensitive amine oxidase (ambiguous) SSAO (ambiguous) |
| UniprotKB: Accession Number | Entry name | Activity | Subunit | Subcellular location | Cofactor |
|---|---|---|---|---|---|
| P46883 | AMO_ECOLI | RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2). 2-phenylethylamine + H(2)O + O(2) = phenylacetaldehyde + NH(3) + H(2)O(2). | Homodimer. | Periplasm. | Binds 1 copper ion per subunit. Binds 2 calcium ions per subunit. Contains 1 topaquinone per subunit. |
| KEGG Pathways | Map code | Pathways | E.C. |
|---|---|---|
| MAP00260 | Glycine, serine and threonine metabolism | |
| MAP00350 | Tyrosine metabolism | |
| MAP00360 | Phenylalanine metabolism | |
| MAP00410 | beta-Alanine metabolism | |
| MAP00960 | Alkaloid biosynthesis II |
| Compound table | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cofactors | Substrates | Products | Intermediates | ||||||||||||||||
| KEGG-id | C00070 | C00076 | L00003 | C00375 | C00001 | C00007 | C00071 | C00014 | C00027 | I00021 | I00022 | I00023 | I00024 | ||||||
| E.C. | |||||||||||||||||||
| Compound | Copper | Calcium | Topaquinone | RCH2NH2 | H2O | Oxygen | Aldehyde | NH3 | H2O2 | Substrate Schiff-base (Iminoquinone=substrate) | Carbanionic intermediate | Product Schiff-base (Aminoquinol=product) | Aminoquinol/Semiquinone | Iminoquinone | |||||
| Type | heavy metal | divalent metal (Ca2+, Mg2+) | amino acids,aromatic ring (only carbon atom) | amine group | H2O | others | carbohydrate | amine group,organic ion | others | ||||||||||
| ChEBI |
28694 30052 28694 30052 |
29108 29108 |
36077 68431 36077 68431 |
15377 15377 |
15379 26689 27140 15379 26689 27140 |
16134 16134 |
16240 16240 |
||||||||||||
| PubChem |
23978 23978 |
271 271 |
22247451 962 22247451 962 |
977 977 |
222 222 |
22326046 784 22326046 784 |
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| 1d6uA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1d6uB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1d6yA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1d6yB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1d6zA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1d6zB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1jrqA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1jrqB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1lvnA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1lvnB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1oacA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1oacB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1spuA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1spuB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1dyuA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1dyuB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qafA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qafB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qakA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qakB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qalA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qalB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1d6uA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1d6uB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1d6yA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1d6yB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1d6zA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1d6zB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1jrqA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1jrqB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1lvnA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1lvnB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1oacA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1oacB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1spuA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1spuB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1dyuA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1dyuB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qafA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qafB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qakA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qakB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qalA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qalB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1d6uA03 |
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Bound:_CU | Bound:2x_CA | Analogue:TYQ_466 | Unbound | Unbound | Bound:HY1 | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-bound:TYQ_466 | Unbound | |
| 1d6uB03 |
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Bound:_CU | Bound:2x_CA | Analogue:TYQ_466 | Unbound | Unbound | Bound:HY1 | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-bound:TYQ_466 | Unbound | |
| 1d6yA03 |
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Bound:_CU | Bound:2x_CA | Analogue:TYQ_466 | Unbound | Analogue:_NO | Bound:HY1 | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-bound:TYQ_466 | Unbound | |
| 1d6yB03 |
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Bound:_CU | Bound:2x_CA | Analogue:TYQ_466 | Unbound | Analogue:_NO | Bound:HY1 | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-bound:TYQ_466 | Unbound | |
| 1d6zA03 |
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Bound:_CU | Bound:2x_CA | Analogue:TYY_466 | Unbound | Unbound | Bound:HY1 | Unbound | Bound:PEO | Unbound | Unbound | Unbound | Unbound | Intermediate-bound:TYY_466 | |
| 1d6zB03 |
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Bound:_CU | Bound:2x_CA | Analogue:TYY_466 | Unbound | Unbound | Bound:HY1 | Unbound | Bound:PEO | Unbound | Unbound | Unbound | Unbound | Intermediate-bound:TYY_466 | |
| 1jrqA03 |
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Bound:_CU | Bound:2x_CA | Bound:TPQ_466 | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1jrqB03 |
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Bound:_CU | Bound:2x_CA | Bound:TPQ_466 | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1lvnA03 |
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Bound:_CU | Bound:2x_CA | Analogue:TYT_466 | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:TYT_466 | Unbound | Unbound | Unbound | Unbound | |
| 1lvnB03 |
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Bound:_CU | Bound:2x_CA | Analogue:TYT_466 | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:TYT_466 | Unbound | Unbound | Unbound | Unbound | |
| 1oacA03 |
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Bound:_CU | Bound:2x_CA | Bound:TPQ_466 | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1oacB03 |
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Bound:_CU | Bound:2x_CA | Bound:TPQ_466 | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1spuA03 |
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Bound:_CU | Bound:2x_CA | Analogue:PAQ_466 | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:PAQ_466 | Unbound | Unbound | Unbound | Unbound | |
| 1spuB03 |
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Bound:_CU | Bound:2x_CA | Analogue:PAQ_466 | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:PAQ_466 | Unbound | Unbound | Unbound | Unbound | |
| 1dyuA03 |
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Bound:_CU | Bound:2x_CA | Bound:TPQ_466 | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1dyuB03 |
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Bound:_CU | Bound:2x_CA | Bound:TPQ_466 | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qafA03 |
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Bound:_CU | Bound:2x_CA | Bound:TPQ_466 | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qafB03 |
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Bound:_CU | Bound:2x_CA | Bound:TPQ_466 | Analogue:GOL | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qakA03 |
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Bound:_CU | Bound:2x_CA | Bound:TPQ_466 | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qakB03 |
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Bound:_CU | Bound:2x_CA | Bound:TPQ_466 | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qalA03 |
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Bound:_CU | Bound:2x_CA | Bound:TPQ_466 | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qalB03 |
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Bound:_CU | Bound:2x_CA | Bound:TPQ_466 | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1d6uA04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1d6uB04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1d6yA04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1d6yB04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1d6zA04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1d6zB04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1jrqA04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1jrqB04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1lvnA04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1lvnB04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1oacA04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1oacB04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1spuA04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1spuB04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1dyuA04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1dyuB04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qafA04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qafB04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qakA04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qakB04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qalA04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qalB04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| Reference for Active-site residues | ||
|---|---|---|
| resource | references | E.C. |
| Active-site residues | ||||||||||
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| PDB | Catalytic residues | Cofactor-binding residues | Modified residues | Main-chain involved in catalysis | Comment | |||||
| 1d6uA01 |
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| 1jrqA01 |
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| 1lvnA01 |
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| 1lvnB01 |
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| 1oacA01 |
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| 1spuA01 |
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| 1dyuA01 |
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| 1dyuB01 |
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| 1qafA01 |
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| 1qafB01 |
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| 1qakA01 |
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| 1qakB01 |
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| 1qalA01 |
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| 1qalB01 |
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| 1d6uA02 |
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| 1d6uB02 |
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| 1d6yA02 |
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| 1d6yB02 |
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| 1d6zA02 |
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| 1d6zB02 |
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| 1jrqA02 |
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| 1jrqB02 |
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| 1lvnA02 |
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| 1lvnB02 |
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| 1oacA02 |
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| 1oacB02 |
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| 1spuA02 |
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| 1spuB02 |
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| 1dyuA02 |
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| 1dyuB02 |
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| 1qafA02 |
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| 1qafB02 |
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| 1qakA02 |
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| 1qakB02 |
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| 1qalA02 |
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| 1qalB02 |
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| 1d6uA03 |
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TYR 369;ASP 383 | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TYQ 466(aminoquinol) | ||
| 1d6uB03 |
|
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TYR 369;ASP 383 | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TYQ 466(aminoquinol) | ||
| 1d6yA03 |
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TYR 369;ASP 383 | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TYQ 466(aminoquinol) | ||
| 1d6yB03 |
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TYR 369;ASP 383 | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TYQ 466(aminoquinol) | ||
| 1d6zA03 |
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TYR 369;ASP 383 | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TYY 466(iminoquinone) | ||
| 1d6zB03 |
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TYR 369;ASP 383 | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TYY 466(iminoquinone) | ||
| 1jrqA03 |
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;ASP 383 | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TPQ 466(topaquinone) | mutant Y369F | |
| 1jrqB03 |
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;ASP 383 | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TPQ 466(topaquinone) | mutant Y369F | |
| 1lvnA03 |
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TYR 369;ASP 383 | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TYT 466(iminoquinone-substrate analogue) | ||
| 1lvnB03 |
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TYR 369;ASP 383 | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TYT 466(iminoquinone-substrate analogue) | ||
| 1oacA03 |
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TYR 369;ASP 383 | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TPQ 466(topaquinone) | ||
| 1oacB03 |
|
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TYR 369;ASP 383 | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TPQ 466(topaquinone) | ||
| 1spuA03 |
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|
TYR 369;ASP 383 | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | PAQ 466(2-oxy-4-hydroxy-5-(2-hydrazinopyridine)phenylalanine) | ||
| 1spuB03 |
|
|
|
|
|
TYR 369;ASP 383 | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | PAQ 466(2-oxy-4-hydroxy-5-(2-hydrazinopyridine)phenylalanine) | ||
| 1dyuA03 |
|
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|
TYR 369;ASP 383 | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TYR 466(topaquinone) | ||
| 1dyuB03 |
|
|
|
|
|
TYR 369;ASP 383 | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TYR 466(topaquinone) | ||
| 1qafA03 |
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|
TYR 369; | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TPQ 466(topaquinone) | mutant D383E | |
| 1qafB03 |
|
|
|
|
|
TYR 369; | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TPQ 466(topaquinone) | mutant D383E | |
| 1qakA03 |
|
|
|
|
|
TYR 369; | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TPQ 466(topaquinone) | mutant D383A | |
| 1qakB03 |
|
|
|
|
|
TYR 369; | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TPQ 466(topaquinone) | mutant D383A | |
| 1qalA03 |
|
|
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|
|
TYR 369; | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TPQ 466(topaquinone) | mutant D383N | |
| 1qalB03 |
|
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|
|
TYR 369; | HIS 524;HIS 526;HIS 689(Copper);ASP 533;LEU 534;ASP 535;ASP 678;ALA 679(Calcium-1);GLU 573;TYR 667;ASP 670;GLU 672(Calcium-2) | TPQ 466(topaquinone) | mutant D383N | |
| 1d6uA04 |
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| 1d6uB04 |
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| 1d6yA04 |
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| 1d6yB04 |
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| 1d6zA04 |
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| 1d6zB04 |
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| 1jrqA04 |
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| 1jrqB04 |
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| 1lvnA04 |
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| 1lvnB04 |
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| 1oacA04 |
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| 1oacB04 |
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| 1spuA04 |
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| 1spuB04 |
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| 1dyuA04 |
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| 1dyuB04 |
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| 1qafA04 |
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| 1qafB04 |
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| 1qakA04 |
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| 1qakB04 |
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| 1qalA04 |
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| 1qalB04 |
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| References for Catalytic Mechanism | ||
|---|---|---|
| References | Sections | No. of steps in catalysis |
|
[5]
|
Scheme II, p.60-62 | |
|
[6]
|
Fig. 1, p.1128-1129 | |
|
[7]
|
Fig.1, p.1178-1179 | |
|
[9]
|
Scheme 1, p.5586-5588 | |
|
[10]
|
Fig.2, Fig.10, p.1617-1619 | |
|
[11]
|
Scheme 23, Scheme 24, p.746-747 | |
|
[12]
|
Fig.1, p.8224-8226 | |
|
[13]
|
Fig.2, p.1725-1728 | |
|
[15]
|
Fig.2, p.12814-12817 | |
|
[17]
|
Scheme 1, Fig.1, p.4694-4605 | |
|
[18]
|
Scheme 1, p.814-815 | |
|
[21]
|
Fig.4, Fig.6, p.313-315 | |
|
[22]
|
Scheme 1, Fig.1, p.494-496 | |
|
[23]
|
Scheme 2 | |
| References | |
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| Medline ID | |
| PubMed ID | 8155661 |
| Journal | Biochemistry |
| Year | 1994 |
| Volume | 33 |
| Pages | 4425-31 |
| Authors | Bossa M, Morpurgo GO, Morpurgo L |
| Title | Models and molecular orbital semiempirical calculations in the study of the spectroscopic properties of bovine serum amine oxidase quinone cofactor. |
| Related PDB | |
| Related UniProtKB | |
| [2] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8176752 |
| Journal | J Mol Biol |
| Year | 1994 |
| Volume | 238 |
| Pages | 635-7 |
| Authors | Roh JH, Suzuki H, Kumagai H, Yamashita M, Azakami H, Murooka Y, Mikami B |
| Title | Crystallization and preliminary X-ray analysis of copper amine oxidase from Escherichia coli K-12. |
| Related PDB | |
| Related UniProtKB | |
| [3] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8585612 |
| Journal | Anal Biochem |
| Year | 1995 |
| Volume | 230 |
| Pages | 159-66 |
| Authors | Steinebach V, Groen BW, Wijmenga SS, Niessen WM, Jongejan JA, Duine JA |
| Title |
Identification of topaquinone, |
| Related PDB | |
| Related UniProtKB | |
| [4] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7766611 |
| Journal | Biochemistry |
| Year | 1995 |
| Volume | 34 |
| Pages | 7020-6 |
| Authors | Moenne-Loccoz P, Nakamura N, Steinebach V, Duine JA, Mure M, Klinman JP, Sanders-Loehr J |
| Title | Characterization of the topa quinone cofactor in amine oxidase from Escherichia coli by resonance Raman spectroscopy. |
| Related PDB | |
| Related UniProtKB | |
| [5] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8524164 |
| Journal | Methods Enzymol |
| Year | 1995 |
| Volume | 258 |
| Pages | 53-69 |
| Authors | Sayre LM, Lee Y |
| Title | Catalytic aerobic deamination of activated primary amines by a model for the quinone cofactor of mammalian copper amine oxidases. |
| Related PDB | |
| Related UniProtKB | |
| [6] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8591022 |
| Journal | Structure |
| Year | 1995 |
| Volume | 3 |
| Pages | 1127-9 |
| Authors | Fontecave M, Eklund H |
| Title | Copper amine oxidase: a novel use for a tyrosine. |
| Related PDB | |
| Related UniProtKB | |
| [7] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 8591028 |
| Journal | Structure |
| Year | 1995 |
| Volume | 3 |
| Pages | 1171-84 |
| Authors | Parsons MR, Convery MA, Wilmot CM, Yadav KD, Blakeley V, Corner AS, Phillips SE, McPherson MJ, Knowles PF |
| Title | Crystal structure of a quinoenzyme: copper amine oxidase of Escherichia coli at 2 A resolution. |
| Related PDB | 1oac |
| Related UniProtKB | |
| [8] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8706668 |
| Journal | Eur J Biochem |
| Year | 1996 |
| Volume | 238 |
| Pages | 683-9 |
| Authors | Steinebach V, De Jong GA, Wijmenga SS, De Vries S, Duine JA |
| Title | The copper-topaquinone-phenylhydrazine-adduct geometry in Escherichia coli amine oxidase derivatized with phenylhydrazines substituted with 19F-NMR relaxation measurements. |
| Related PDB | |
| Related UniProtKB | |
| [9] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8621418 |
| Journal | J Biol Chem |
| Year | 1996 |
| Volume | 271 |
| Pages | 5580-8 |
| Authors | Steinebach V, de Vries S, Duine JA |
| Title | Intermediates in the catalytic cycle of copper-quinoprotein amine oxidase from Escherichia coli. |
| Related PDB | |
| Related UniProtKB | |
| [10] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) |
| Medline ID | 97200715 |
| PubMed ID | 9048544 |
| Journal | Biochemistry |
| Year | 1997 |
| Volume | 36 |
| Pages | 1608-20 |
| Authors | Wilmot CM, Murray JM, Alton G, Parsons MR, Convery MA, Blakeley V, Corner AS, Palcic MM, Knowles PF, McPherson MJ, Phillips SE |
| Title | Catalytic mechanism of the quinoenzyme amine oxidase from Escherichia coli: exploring the reductive half-reaction. |
| Related PDB | 1spu |
| Related UniProtKB | P46883 |
| [11] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11848913 |
| Journal | Chem Rev |
| Year | 1998 |
| Volume | 98 |
| Pages | 705-762 |
| Authors | Stubbe J, van Der Donk WA |
| Title | Protein Radicals in Enzyme Catalysis. |
| Related PDB | |
| Related UniProtKB | |
| [12] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) |
| Medline ID | 99315198 |
| PubMed ID | 10387067 |
| Journal | Biochemistry |
| Year | 1999 |
| Volume | 38 |
| Pages | 8217-27 |
| Authors | Murray JM, Saysell CG, Wilmot CM, Tambyrajah WS, Jaeger J, Knowles PF, Phillips SE, McPherson MJ |
| Title | The active site base controls cofactor reactivity in Escherichia coli amine oxidase: x-ray crystallographic studies with mutational variants. |
| Related PDB | |
| Related UniProtKB | P46883 |
| [13] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) |
| Medline ID | 20045000 |
| PubMed ID | 10576737 |
| Journal | Science |
| Year | 1999 |
| Volume | 286 |
| Pages | 1724-8 |
| Authors | Wilmot CM, Hajdu J, McPherson MJ, Knowles PF, Phillips SE |
| Title | Visualization of dioxygen bound to copper during enzyme catalysis. |
| Related PDB | 1d6u 1d6y 1d6z |
| Related UniProtKB | P46883 |
| [14] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11665487 |
| Journal | Adv Protein Chem |
| Year | 2001 |
| Volume | 58 |
| Pages | 141-74 |
| Authors | Dove JE, Klinman JP |
| Title | Trihydroxyphenylalanine quinone (TPQ) from copper amine oxidases and lysyl tyrosylquinone (LTQ) from lysyl oxidase. |
| Related PDB | |
| Related UniProtKB | |
| [15] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11669617 |
| Journal | Biochemistry |
| Year | 2001 |
| Volume | 40 |
| Pages | 12808-18 |
| Authors | Murray JM, Kurtis CR, Tambyrajah W, Saysell CG, Wilmot CM, Parsons MR, Phillips SE, Knowles PF, McPherson MJ |
| Title | Conserved tyrosine-369 in the active site of Escherichia coli copper amine oxidase is not essential. |
| Related PDB | 1jrq |
| Related UniProtKB | |
| [16] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11751046 |
| Journal | Curr Opin Struct Biol |
| Year | 2001 |
| Volume | 11 |
| Pages | 666-73 |
| Authors | Dawkes HC, Phillips SE |
| Title | Copper amine oxidase: cunning cofactor and controversial copper. |
| Related PDB | |
| Related UniProtKB | |
| [17] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11532005 |
| Journal | Eur J Biochem |
| Year | 2001 |
| Volume | 268 |
| Pages | 4686-97 |
| Authors | Padiglia A, Medda R, Lorrai A, Paci M, Pedersen JZ, Boffi A, Bellelli A, Agro AF, Floris G |
| Title | Irreversible inhibition of pig kidney copper-containing amine oxidase by sodium and lithium ions. |
| Related PDB | |
| Related UniProtKB | |
| [18] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11985492 |
| Journal | Biochem J |
| Year | 2002 |
| Volume | 365 |
| Pages | 809-16 |
| Authors | Saysell CG, Tambyrajah WS, Murray JM, Wilmot CM, Phillips SE, McPherson MJ, Knowles PF |
| Title | Probing the catalytic mechanism of Escherichia coli amine oxidase using mutational variants and a reversible inhibitor as a substrate analogue. |
| Related PDB | |
| Related UniProtKB | |
| [19] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11781110 |
| Journal | Biochemistry |
| Year | 2002 |
| Volume | 41 |
| Pages | 687-96 |
| Authors | Green EL, Nakamura N, Dooley DM, Klinman JP, Sanders-Loehr J |
| Title | Rates of oxygen and hydrogen exchange as indicators of TPQ cofactor orientation in amine oxidases. |
| Related PDB | |
| Related UniProtKB | |
| [20] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12153561 |
| Journal | Eur J Biochem |
| Year | 2002 |
| Volume | 269 |
| Pages | 3645-58 |
| Authors | Shepard EM, Smith J, Elmore BO, Kuchar JA, Sayre LM, Dooley DM |
| Title |
Towards the development of selective amine oxidase inhibitors. |
| Related PDB | |
| Related UniProtKB | |
| [21] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12078505 |
| Journal | Methods Enzymol |
| Year | 2002 |
| Volume | 353 |
| Pages | 301-18 |
| Authors | Wilmot CM, Sjogren T, Carlsson GH, Berglund GI, Hajdu J |
| Title | Defining redox state of X-ray crystal structures by single-crystal ultraviolet-visible microspectrophotometry. |
| Related PDB | |
| Related UniProtKB | |
| [22] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12773142 |
| Journal | Biochem Soc Trans |
| Year | 2003 |
| Volume | 31 |
| Pages | 493-6 |
| Authors | Wilmot CM |
| Title | Oxygen activation in a copper-containing amine oxidase. |
| Related PDB | |
| Related UniProtKB | |
| [23] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 15234266 |
| Journal | Arch Biochem Biophys |
| Year | 2004 |
| Volume | 428 |
| Pages | 22-31 |
| Authors | Brazeau BJ, Johnson BJ, Wilmot CM |
| Title |
Copper-containing amine oxidases. |
| Related PDB | |
| Related UniProtKB | |
| [24] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 15498552 |
| Journal | FEBS Lett |
| Year | 2004 |
| Volume | 576 |
| Pages | 301-5 |
| Authors | Wilmot CM, Saysell CG, Blessington A, Conn DA, Kurtis CR, McPherson MJ, Knowles PF, Phillips SE |
| Title | Medical implications from the crystal structure of a copper-containing amine oxidase complexed with the antidepressant drug tranylcypromine. |
| Related PDB | 1lvn |
| Related UniProtKB | |
| [25] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 15369390 |
| Journal | J Med Chem |
| Year | 2004 |
| Volume | 47 |
| Pages | 4865-74 |
| Authors | Marti L, Abella A, De La Cruz X, Garcia-Vicente S, Unzeta M, Carpene C, Palacin M, Testar X, Orozco M, Zorzano A |
| Title | Exploring the binding mode of semicarbazide-sensitive amine oxidase/VAP-1: identification of novel substrates with insulin-like activity. |
| Related PDB | |
| Related UniProtKB | |
| Comments |
|---|
|
Cofactor, Although this enzyme binds a copper ion and two calcium ions as cofactors per subunit, The following compounds can be inculded as substrate and product, Phenethylamine;C05332 Phenylacetaldehyde;C00601 According to the literature [13], (I) Reductive half-reaction: (A) Exchange of double-bonded atoms; Schiff-base formation; Substrate amine forms a Schiff-base with topaquinone, (B) Isomerization from iminoquinone=substrate complex to aminoquinol=product complex: (C) Exchange of double-bonded atoms; Schiff-base deformation; H2O reacts with the intermediate, (II) Oxidative half-reaction: (D) Reduction of dioxygen (O2) by aminoquinol, (E) Exchange of double-bonded atoms; Schiff-base deformation; H2O reacts with the intermediate, |
| Created | Updated |
|---|---|
| 2005-05-26 | 2009-02-26 |