DB code: M00185
| CATH domain | 3.90.1240.10 : Zincin-like | Catalytic domain |
|---|---|---|
| -.-.-.- : | ||
| 2.60.120.200 : Jelly Rolls | ||
| 2.80.10.50 : Trefoil (Acidic Fibroblast Growth Factor, subunit A) | ||
| E.C. | 3.4.24.68 | |
| CSA | ||
| M-CSA | ||
| MACiE | ||
| CATH domain | Related DB codes (homologues) |
|---|---|
| 2.60.120.200 : Jelly Rolls | S00148 D00535 D00666 S00511 T00064 T00208 |
| 2.80.10.50 : Trefoil (Acidic Fibroblast Growth Factor, subunit A) | D00169 D00666 |
| Uniprot Enzyme Name | UniprotKB | Protein name | Synonyms | Contains | RefSeq | MEROPS | Pfam |
|---|---|---|---|---|---|---|
| P04958 |
Tetanus toxin
|
EC
3.4.24.68
Tentoxylysin |
Tetanus toxin light chain
(Tetanus toxin chain L) Tetanus toxin heavy chain (Tetanus toxin chain H) |
NP_783831.1
(Protein)
NC_004565.1 (DNA/RNA sequence) |
M27.001
(Metallo)
|
PF01742
(Peptidase_M27)
PF07951 (Toxin_R_bind_C) PF07953 (Toxin_R_bind_N) PF07952 (Toxin_trans) [Graphical View] |
| KEGG enzyme name |
|---|
|
tentoxilysin
tetanus neurotoxin |
| UniprotKB: Accession Number | Entry name | Activity | Subunit | Subcellular location | Cofactor |
|---|---|---|---|---|---|
| P04958 | TETX_CLOTE | Hydrolysis of 76-Gln-|-Phe-77 bond in synaptobrevin 2. | The precursor polypeptide is subsequently cleaved to yield subchains L and H. These remain linked by a disulfide bridge and are non-toxic after separation. | Binds 1 zinc ion per subunit (By similarity). |
| KEGG Pathways | Map code | Pathways | E.C. |
|---|
| Compound table | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cofactors | Substrates | Products | Intermediates | ||||||||
| KEGG-id | C00038 | C99999 | C00001 | C00017 | C00012 | ||||||
| E.C. | |||||||||||
| Compound | Zinc | Synaptobrevin 2 | H2O | Protein | Peptide | ||||||
| Type | heavy metal | peptide/protein | H2O | peptide/protein | peptide/protein | ||||||
| ChEBI |
29105 29105 |
15377 15377 |
|||||||||
| PubChem |
32051 32051 |
22247451 962 22247451 962 |
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| 1yvgA |
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Bound:_ZN | Unbound | Unbound | Unbound | ||
| 1z7hA |
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Bound:_ZN | Unbound | Unbound | Unbound | ||
| 1a8dA01 |
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Unbound | Unbound | Unbound | Unbound | ||
| 1af9A01 |
|
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Unbound | Unbound | Unbound | Unbound | ||
| 1d0hA01 |
|
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Unbound | Unbound | Unbound | Unbound | ||
| 1dfqA01 |
|
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Unbound | Unbound | Unbound | Unbound | ||
| 1diwA01 |
|
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Unbound | Unbound | Unbound | Unbound | ||
| 1dllA01 |
|
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Unbound | Unbound | Unbound | Unbound | ||
| 1fv2A01 |
|
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Unbound | Unbound | Unbound | Unbound | ||
| 1fv3A01 |
|
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Unbound | Unbound | Unbound | Unbound | ||
| 1fv3B01 |
|
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Unbound | Unbound | Unbound | Unbound | ||
| 1yxwA01 |
|
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Unbound | Unbound | Unbound | Unbound | ||
| 1yynA01 |
|
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Unbound | Unbound | Unbound | Unbound | ||
| 1a8dA02 |
|
|
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|
|
Unbound | Unbound | Unbound | Unbound | ||
| 1af9A02 |
|
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Unbound | Unbound | Unbound | Unbound | ||
| 1d0hA02 |
|
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|
Unbound | Unbound | Unbound | Unbound | ||
| 1dfqA02 |
|
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|
|
|
Unbound | Unbound | Unbound | Unbound | ||
| 1diwA02 |
|
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Unbound | Unbound | Unbound | Unbound | ||
| 1dllA02 |
|
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Unbound | Unbound | Unbound | Unbound | ||
| 1fv2A02 |
|
|
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|
|
Unbound | Unbound | Unbound | Unbound | ||
| 1fv3A02 |
|
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Unbound | Unbound | Unbound | Unbound | ||
| 1fv3B02 |
|
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Unbound | Unbound | Unbound | Unbound | ||
| 1yxwA02 |
|
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|
|
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Unbound | Unbound | Unbound | Unbound | ||
| 1yynA02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | ||
| Reference for Active-site residues | ||
|---|---|---|
| resource | references | E.C. |
| Swiss-prot;P04958 & literature [6], [8], [32], [36], [38] | ||
| Active-site residues | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Catalytic residues | Cofactor-binding residues | Modified residues | Main-chain involved in catalysis | Comment | |||||
| 1yvgA |
|
|
|
|
|
GLU 233;GLU 270;ARG 371;TYR 374 | HIS 232;HIS 236;GLU 270(Zinc binding) | |||
| 1z7hA |
|
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|
GLU 234;GLU 271;ARG 372;TYR 375 | HIS 233;HIS 237;GLU 271(Zinc binding) | |||
| 1a8dA01 |
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| 1af9A01 |
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| 1d0hA01 |
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| 1dfqA01 |
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| 1diwA01 |
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| 1dllA01 |
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| 1fv2A01 |
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| 1fv3A01 |
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| 1fv3B01 |
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| 1yxwA01 |
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| 1yynA01 |
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| 1a8dA02 |
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| 1af9A02 |
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| 1d0hA02 |
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| 1dfqA02 |
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| 1diwA02 |
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| 1dllA02 |
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| 1fv2A02 |
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| 1fv3A02 |
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| 1fv3B02 |
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| 1yxwA02 |
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| 1yynA02 |
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| References for Catalytic Mechanism | ||
|---|---|---|
| References | Sections | No. of steps in catalysis |
|
[6]
|
||
|
[8]
|
||
|
[25]
|
p.1098-1102 | |
|
[32]
|
||
|
[35]
|
p.555-556 | |
|
[36]
|
p.7454-7455 | |
|
[38]
|
p.932-936 | |
| References | |
|---|---|
| [1] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 2207279 |
| Journal | Biophys Chem |
| Year | 1990 |
| Volume | 36 |
| Pages | 155-66 |
| Authors | Singh BR, Fuller MP, Schiavo G |
| Title | Molecular structure of tetanus neurotoxin as revealed by Fourier transform infrared and circular dichroic spectroscopy. |
| Related PDB | |
| Related UniProtKB | |
| [2] | |
| Resource | |
| Comments | IDENTIFICATION AS ZINC-PROTEASE. |
| Medline ID | 93010948 |
| PubMed ID | 1396558 |
| Journal | EMBO J |
| Year | 1992 |
| Volume | 11 |
| Pages | 3577-83 |
| Authors | Schiavo G, Poulain B, Rossetto O, Benfenati F, Tauc L, Montecucco C |
| Title | Tetanus toxin is a zinc protein and its inhibition of neurotransmitter release and protease activity depend on zinc. |
| Related PDB | |
| Related UniProtKB | P04958 |
| [3] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1331807 |
| Journal | Nature |
| Year | 1992 |
| Volume | 359 |
| Pages | 832-5 |
| Authors | Schiavo G, Benfenati F, Poulain B, Rossetto O, Polverino de Laureto P, DasGupta BR, Montecucco C |
| Title | Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin. |
| Related PDB | |
| Related UniProtKB | |
| [4] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8332193 |
| Journal | Nature |
| Year | 1993 |
| Volume | 364 |
| Pages | 346-9 |
| Authors | McMahon HT, Ushkaryov YA, Edelmann L, Link E, Binz T, Niemann H, Jahn R, Sudhof TC |
| Title | Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein. |
| Related PDB | |
| Related UniProtKB | |
| [5] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7901925 |
| Journal | Trends Biochem Sci |
| Year | 1993 |
| Volume | 18 |
| Pages | 324-7 |
| Authors | Montecucco C, Schiavo G |
| Title | Tetanus and botulism neurotoxins: a new group of zinc proteases. |
| Related PDB | |
| Related UniProtKB | |
| [6] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7911329 |
| Journal | Biochemistry |
| Year | 1994 |
| Volume | 33 |
| Pages | 7014-20 |
| Authors | Li Y, Foran P, Fairweather NF, de Paiva A, Weller U, Dougan G, Dolly JO |
| Title | A single mutation in the recombinant light chain of tetanus toxin abolishes its proteolytic activity and removes the toxicity seen after reconstitution with native heavy chain. |
| Related PDB | |
| Related UniProtKB | |
| [7] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7527117 |
| Journal | Mol Microbiol |
| Year | 1994 |
| Volume | 13 |
| Pages | 1-8 |
| Authors | Montecucco C, Schiavo G |
| Title | Mechanism of action of tetanus and botulinum neurotoxins. |
| Related PDB | |
| Related UniProtKB | |
| [8] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8197120 |
| Journal | Proc Natl Acad Sci U S A |
| Year | 1994 |
| Volume | 91 |
| Pages | 4688-92 |
| Authors | Yamasaki S, Hu Y, Binz T, Kalkuhl A, Kurazono H, Tamura T, Jahn R, Kandel E, Niemann H |
| Title | Synaptobrevin/vesicle-associated membrane protein (VAMP) of Aplysia californica: structure and proteolysis by tetanus toxin and botulinal neurotoxins type D and F. |
| Related PDB | |
| Related UniProtKB | |
| [9] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7731948 |
| Journal | Proteins |
| Year | 1994 |
| Volume | 20 |
| Pages | 293-300 |
| Authors | Lebeda FJ, Olson MA |
| Title | Secondary structural predictions for the clostridial neurotoxins. |
| Related PDB | |
| Related UniProtKB | |
| [10] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7801345 |
| Journal | Toxicon |
| Year | 1994 |
| Volume | 32 |
| Pages | 1095-104 |
| Authors | Ledoux DN, Be XH, Singh BR |
| Title | Quaternary structure of botulinum and tetanus neurotoxins as probed by chemical cross-linking and native gel electrophoresis. |
| Related PDB | |
| Related UniProtKB | |
| [11] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7744050 |
| Journal | Eur J Biochem |
| Year | 1995 |
| Volume | 229 |
| Pages | 61-9 |
| Authors | De Filippis V, Vangelista L, Schiavo G, Tonello F, Montecucco C |
| Title | Structural studies on the zinc-endopeptidase light chain of tetanus neurotoxin. |
| Related PDB | |
| Related UniProtKB | |
| [12] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7581298 |
| Journal | J Physiol Paris |
| Year | 1995 |
| Volume | 89 |
| Pages | 43-50 |
| Authors | Rossetto O, Deloye F, Poulain B, Pellizzari R, Schiavo G, Montecucco C |
| Title | The metallo-proteinase activity of tetanus and botulism neurotoxins. |
| Related PDB | |
| Related UniProtKB | |
| [13] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8771234 |
| Journal | Q Rev Biophys |
| Year | 1995 |
| Volume | 28 |
| Pages | 423-72 |
| Authors | Montecucco C, Schiavo G |
| Title | Structure and function of tetanus and botulinum neurotoxins. |
| Related PDB | |
| Related UniProtKB | |
| [14] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8702770 |
| Journal | J Biol Chem |
| Year | 1996 |
| Volume | 271 |
| Pages | 20353-8 |
| Authors | Pellizzari R, Rossetto O, Lozzi L, Giovedi' S, Johnson E, Shone CC, Montecucco C |
| Title | Structural determinants of the specificity for synaptic vesicle-associated membrane protein/synaptobrevin of tetanus and botulinum type B and G neurotoxins. |
| Related PDB | |
| Related UniProtKB | |
| [15] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9065770 |
| Journal | Biochem J |
| Year | 1997 |
| Volume | 322 |
| Pages | 507-10 |
| Authors | Tonello F, Schiavo G, Montecucco C |
| Title | Metal substitution of tetanus neurotoxin. |
| Related PDB | |
| Related UniProtKB | |
| [16] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9013591 |
| Journal | J Biol Chem |
| Year | 1997 |
| Volume | 272 |
| Pages | 3459-64 |
| Authors | Cornille F, Martin L, Lenoir C, Cussac D, Roques BP, Fournie-Zaluski MC |
| Title | Cooperative exosite-dependent cleavage of synaptobrevin by tetanus toxin light chain. |
| Related PDB | |
| Related UniProtKB | |
| [17] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 874-1314. |
| Medline ID | 97475217 |
| PubMed ID | 9334741 |
| Journal | Nat Struct Biol |
| Year | 1997 |
| Volume | 4 |
| Pages | 788-92 |
| Authors | Umland TC, Wingert LM, Swaminathan S, Furey WF, Schmidt JJ, Sax M |
| Title | Structure of the receptor binding fragment HC of tetanus neurotoxin. |
| Related PDB | 1af9 |
| Related UniProtKB | P04958 |
| [18] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | |
| Journal | Am Cryst Assoc Abstr Papers |
| Year | 1998 |
| Volume | 25 |
| Pages | 90 |
| Authors | Knapp M, Segelke B, Rupp B |
| Title | The 1.61 Angstrom Structure of the Tetanus Toxin Ganglioside Binding Region: Solved by MAD and Mir Phase Combination. |
| Related PDB | 1a8d |
| Related UniProtKB | |
| [19] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9746536 |
| Journal | Biophys J |
| Year | 1998 |
| Volume | 75 |
| Pages | 1953-63 |
| Authors | Meneghini C, Morante S |
| Title | The active site structure of tetanus neurotoxin resolved by multiple scattering analysis in X-Ray absorption spectroscopy. |
| Related PDB | |
| Related UniProtKB | |
| [20] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9914258 |
| Journal | Curr Opin Struct Biol |
| Year | 1998 |
| Volume | 8 |
| Pages | 778-84 |
| Authors | Lacy DB, Stevens RC |
| Title | Unraveling the structures and modes of action of bacterial toxins. |
| Related PDB | |
| Related UniProtKB | |
| [21] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9719598 |
| Journal | J Med Chem |
| Year | 1998 |
| Volume | 41 |
| Pages | 3450-60 |
| Authors | Martin L, Cornille F, Coric P, Roques BP, Fournie-Zaluski MC |
| Title | Beta-amino-thiols inhibit the zinc metallopeptidase activity of tetanus toxin light chain. |
| Related PDB | |
| Related UniProtKB | |
| [22] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9783261 |
| Journal | J Nat Toxins |
| Year | 1998 |
| Volume | 7 |
| Pages | 227-38 |
| Authors | Lebeda FJ, Olson MA |
| Title | Predictions of secondary structure and solvent accessibility of the light chain of the clostridial neurotoxins. |
| Related PDB | |
| Related UniProtKB | |
| [23] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10413679 |
| Journal | J Cell Sci |
| Year | 1999 |
| Volume | 112 |
| Pages | 2715-24 |
| Authors | Lalli G, Herreros J, Osborne SL, Montecucco C, Rossetto O, Schiavo G |
| Title | Functional characterisation of tetanus and botulinum neurotoxins binding domains. |
| Related PDB | |
| Related UniProtKB | |
| [24] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9986722 |
| Journal | J Med Chem |
| Year | 1999 |
| Volume | 42 |
| Pages | 515-25 |
| Authors | Martin L, Cornille F, Turcaud S, Meudal H, Roques BP, Fournie-Zaluski MC |
| Title | Metallopeptidase inhibitors of tetanus toxin: A combinatorial approach. |
| Related PDB | |
| Related UniProtKB | |
| [25] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10518945 |
| Journal | J Mol Biol |
| Year | 1999 |
| Volume | 291 |
| Pages | 1091-104 |
| Authors | Lacy DB, Stevens RC |
| Title | Sequence homology and structural analysis of the clostridial neurotoxins. |
| Related PDB | |
| Related UniProtKB | |
| [26] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10865130 |
| Journal | Biochimie |
| Year | 2000 |
| Volume | 82 |
| Pages | 427-46 |
| Authors | Humeau Y, Doussau F, Grant NJ, Poulain B |
| Title | How botulinum and tetanus neurotoxins block neurotransmitter release. |
| Related PDB | |
| Related UniProtKB | |
| [27] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11018534 |
| Journal | FEBS Lett |
| Year | 2000 |
| Volume | 482 |
| Pages | 119-24 |
| Authors | Ginalski K, Venclovas C, Lesyng B, Fidelis K |
| Title | Structure-based sequence alignment for the beta-trefoil subdomain of the clostridial neurotoxin family provides residue level information about the putative ganglioside binding site. |
| Related PDB | |
| Related UniProtKB | |
| [28] | |
| Resource | |
| Comments | X-ray Diffraction |
| Medline ID | |
| PubMed ID | 10722735 |
| Journal | J Biol Chem |
| Year | 2000 |
| Volume | 275 |
| Pages | 8889-94 |
| Authors | Emsley P, Fotinou C, Black I, Fairweather NF, Charles IG, Watts C, Hewitt E, Isaacs NW |
| Title | The structures of the H(C) fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding. |
| Related PDB | 1d0h 1dfq 1diw 1dll |
| Related UniProtKB | |
| [29] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11716521 |
| Journal | Biochem Biophys Res Commun |
| Year | 2001 |
| Volume | 289 |
| Pages | 623-9 |
| Authors | Munro P, Kojima H, Dupont JL, Bossu JL, Poulain B, Boquet P |
| Title | High sensitivity of mouse neuronal cells to tetanus toxin requires a GPI-anchored protein. |
| Related PDB | |
| Related UniProtKB | |
| [30] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11278003 |
| Journal | FEBS Lett |
| Year | 2001 |
| Volume | 493 |
| Pages | 45-9 |
| Authors | Sutton JM, Chow-Worn O, Spaven L, Silman NJ, Hallis B, Shone CC |
| Title | Tyrosine-1290 of tetanus neurotoxin plays a key role in its binding to gangliosides and functional binding to neurones. |
| Related PDB | |
| Related UniProtKB | |
| [31] | |
| Resource | |
| Comments | X-ray Diffraction |
| Medline ID | |
| PubMed ID | 11418600 |
| Journal | J Biol Chem |
| Year | 2001 |
| Volume | 276 |
| Pages | 32274-81 |
| Authors | Fotinou C, Emsley P, Black I, Ando H, Ishida H, Kiso M, Sinha KA, Fairweather NF, Isaacs NW |
| Title | The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin. |
| Related PDB | 1fv2 1fv3 |
| Related UniProtKB | |
| [32] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11306125 |
| Journal | Toxicon |
| Year | 2001 |
| Volume | 39 |
| Pages | 1151-9 |
| Authors | Rossetto O, Caccin P, Rigoni M, Tonello F, Bortoletto N, Stevens RC, Montecucco C |
| Title | Active-site mutagenesis of tetanus neurotoxin implicates TYR-375 and GLU-271 in metalloproteolytic activity. |
| Related PDB | |
| Related UniProtKB | |
| [33] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10936621 |
| Journal | Toxicon |
| Year | 2001 |
| Volume | 39 |
| Pages | 27-41 |
| Authors | Rossetto O, Seveso M, Caccin P, Schiavo G, Montecucco C |
| Title | Tetanus and botulinum neurotoxins: turning bad guys into good by research. |
| Related PDB | |
| Related UniProtKB | |
| [34] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12145198 |
| Journal | EMBO J |
| Year | 2002 |
| Volume | 21 |
| Pages | 3970-9 |
| Authors | Quetglas S, Iborra C, Sasakawa N, De Haro L, Kumakura K, Sato K, Leveque C, Seagar M |
| Title | Calmodulin and lipid binding to synaptobrevin regulates calcium-dependent exocytosis. |
| Related PDB | |
| Related UniProtKB | |
| [35] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12417130 |
| Journal | Trends Biochem Sci |
| Year | 2002 |
| Volume | 27 |
| Pages | 552-8 |
| Authors | Turton K, Chaddock JA, Acharya KR |
| Title |
Botulinum and tetanus neurotoxins: structure, |
| Related PDB | |
| Related UniProtKB | |
| [36] | |
| Resource | |
| Comments | X-ray Diffraction |
| Medline ID | |
| PubMed ID | 15895988 |
| Journal | Biochemistry |
| Year | 2005 |
| Volume | 44 |
| Pages | 7450-7 |
| Authors | Breidenbach MA, Brunger AT |
| Title | 2.3 A crystal structure of tetanus neurotoxin light chain. |
| Related PDB | 1z7h |
| Related UniProtKB | |
| [37] | |
| Resource | |
| Comments | X-ray Diffraction |
| Medline ID | |
| PubMed ID | 16104015 |
| Journal | Proteins |
| Year | 2005 |
| Volume | 61 |
| Pages | 288-95 |
| Authors | Jayaraman S, Eswaramoorthy S, Kumaran D, Swaminathan S |
| Title | Common binding site for disialyllactose and tri-peptide in C-fragment of tetanus neurotoxin. |
| Related PDB | 1yxw 1yyn |
| Related UniProtKB | |
| [38] | |
| Resource | |
| Comments | X-ray Diffraction |
| Medline ID | |
| PubMed ID | 15904688 |
| Journal | Toxicon |
| Year | 2005 |
| Volume | 45 |
| Pages | 929-39 |
| Authors | Rao KN, Kumaran D, Binz T, Swaminathan S |
| Title | Structural analysis of the catalytic domain of tetanus neurotoxin. |
| Related PDB | 1yvg |
| Related UniProtKB | |
| Comments |
|---|
|
This enzyme belongs to the peptidase family-M27. This enzyme is cleaved into two chains, The structure of the N-terminal domain of the heavy chain has not been solved yet. According to the literature [35], |
| Created | Updated |
|---|---|
| 2005-12-13 | 2009-02-26 |