DB code: M00183
| RLCP classification | 1.15.72000.565 : Hydrolysis | |
|---|---|---|
| CATH domain | 2.30.29.30 : PH-domain like | |
| 1.10.238.10 : Recoverin; domain 1 | ||
| 1.10.238.10 : Recoverin; domain 1 | ||
| 3.20.20.190 : TIM Barrel | Catalytic domain | |
| 2.30.29.30 : PH-domain like | ||
| 3.30.505.10 : SHC Adaptor Protein | ||
| 3.30.505.10 : SHC Adaptor Protein | ||
| 2.30.30.40 : SH3 type barrels. | ||
| 2.60.40.150 : Immunoglobulin-like | ||
| -.-.-.- : | ||
| E.C. | 3.1.4.11 | |
| CSA | ||
| M-CSA | ||
| MACiE | ||
| CATH domain | Related DB codes (homologues) |
|---|---|
| 1.10.238.10 : Recoverin; domain 1 | M00198 D00151 M00118 |
| 2.30.29.30 : PH-domain like | M00125 M00344 M00118 |
| 2.30.30.40 : SH3 type barrels. | M00043 M00130 T00256 M00304 M00335 |
| 2.60.40.150 : Immunoglobulin-like | M00221 M00043 M00118 |
| 3.20.20.190 : TIM Barrel | S00236 M00118 |
| 3.30.505.10 : SHC Adaptor Protein | M00043 M00130 M00148 T00256 M00304 M00333 M00339 M00344 T00221 |
| Uniprot Enzyme Name | UniprotKB | Protein name | Synonyms | RefSeq | Pfam |
|---|---|---|---|---|
| Q9X0A5 |
|
Putative uncharacterized protein
|
NP_228818.1
(Protein)
NC_000853.1 (DNA/RNA sequence) |
[Graphical View] |
| P08487 |
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
|
EC
3.1.4.11
Phosphoinositide phospholipase C Phospholipase C-gamma-1 PLC-gamma-1 PLC-II PLC-148 |
NP_776850.1
(Protein)
NM_174425.3 (DNA/RNA sequence) |
PF00168
(C2)
PF09279 (efhand_like) PF00388 (PI-PLC-X) PF00387 (PI-PLC-Y) PF00017 (SH2) PF00018 (SH3_1) [Graphical View] |
| P19174 |
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
|
EC
3.1.4.11
Phosphoinositide phospholipase C Phospholipase C-gamma-1 PLC-gamma-1 PLC-II PLC-148 |
NP_002651.2
(Protein)
NM_002660.2 (DNA/RNA sequence) NP_877963.1 (Protein) NM_182811.1 (DNA/RNA sequence) |
PF00168
(C2)
PF09279 (efhand_like) PF00388 (PI-PLC-X) PF00387 (PI-PLC-Y) PF00017 (SH2) PF00018 (SH3_1) [Graphical View] |
| KEGG enzyme name |
|---|
|
phosphoinositide phospholipase C
triphosphoinositide phosphodiesterase phosphoinositidase C 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase monophosphatidylinositol phosphodiesterase phosphatidylinositol phospholipase C PI-PLC 1-phosphatidyl-D-myo-inositol-4,5-bisphosphateinositoltrisphosphohydrolase |
| UniprotKB: Accession Number | Entry name | Activity | Subunit | Subcellular location | Cofactor |
|---|---|---|---|---|---|
| Q9X0A5 | Q9X0A5_THEMA | ||||
| P08487 | PLCG1_BOVIN | 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. | Interacts with CENTG1 via its SH3 domain. Interacts with phosphorylated LAT upon TCR activation. Interacts with the Pro- rich domain of TNK1 via its SH3 domain. Associates with BLNK, VAV1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB in activated T-cells, which inhibits phosphorylation. Interacts with SHB. Interacts via its SH3 domain with the Arg/Gly-rich-flanked Pro-rich domains of KHDRBS1/SAM68. This interaction is selectively regulated by arginine methylation of KHDRBS1/SAM68. Interacts with INPP5D/SHIP1 and MIST (By similarity). Interacts with RALGPS1 (By similarity). | Calcium. | |
| P19174 | PLCG1_HUMAN | 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. | Interacts with CENTG1 via its SH3 domain (By similarity). Interacts with phosphorylated LAT upon TCR activation. Interacts with the Pro-rich domain of TNK1 via its SH3 domain. Associates with BLNK, VAV1, GRB2 and NCK1 in a B-cell antigen receptor- dependent fashion. Interacts with CBLB in activated T-cells, which inhibits phosphorylation. Interacts with SHB. Interacts via its SH3 domain with the Arg/Gly-rich-flanked Pro-rich domains of KHDRBS1/SAM68. This interaction is selectively regulated by arginine methylation of KHDRBS1/SAM68. Interacts with INPP5D/SHIP1 and MIST (By similarity). Interacts with RALGPS1. Interacts (via SH3 domain) with HEV ORF3 protein. | Calcium. |
| KEGG Pathways | Map code | Pathways | E.C. |
|---|---|---|
| MAP00562 | Inositol phosphate metabolism | |
| MAP04070 | Phosphatidylinositol signaling system |
| Compound table | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cofactors | Substrates | Products | Intermediates | ||||||||||
| KEGG-id | C00076 | C00001 | C04021 | C04637 | C00165 | C00641 | C01245 | ||||||
| E.C. | |||||||||||||
| Compound | Calcium | H2O | Phosphatidylinositol phosphate | 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate | Diacylglycerol | 1,2-Diacyl-sn-glycerol | D-myo-Inositol 1,4,5-trisphosphate | ||||||
| Type | divalent metal (Ca2+, Mg2+) | H2O | carbohydrate,phosphate group/phosphate ion | carbohydrate,lipid,phosphate group/phosphate ion | carbohydrate,lipid | carbohydrate,lipid | carbohydrate,phosphate group/phosphate ion | ||||||
| ChEBI |
29108 29108 |
15377 15377 |
16595 16595 |
||||||||||
| PubChem |
271 271 |
22247451 962 22247451 962 |
439456 439456 |
||||||||||
| 2fclA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 2pldA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 2pleA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1hspA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1hsqA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 2hspA |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | ||
| Reference for Active-site residues | ||
|---|---|---|
| resource | references | E.C. |
| Active-site residues | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Catalytic residues | Cofactor-binding residues | Modified residues | Main-chain involved in catalysis | Comment | |||||
| 2fclA |
|
|
|
|
|
|||||
| 2pldA |
|
|
|
|
|
|||||
| 2pleA |
|
|
|
|
|
|||||
| 1hspA |
|
|
|
|
|
|||||
| 1hsqA |
|
|
|
|
|
|||||
| 2hspA |
|
|
|
|
|
|||||
| References for Catalytic Mechanism | ||
|---|---|---|
| References | Sections | No. of steps in catalysis |
| References | |
|---|---|
| [1] | |
| Resource | |
| Comments | PHOSPHORYLATION SITES. |
| Medline ID | 90154080 |
| PubMed ID | 1689310 |
| Journal | J Biol Chem |
| Year | 1990 |
| Volume | 265 |
| Pages | 3940-3 |
| Authors | Kim JW, Sim SS, Kim UH, Nishibe S, Wahl MI, Carpenter G, Rhee SG |
| Title | Tyrosine residues in bovine phospholipase C-gamma phosphorylated by the epidermal growth factor receptor in vitro. |
| Related PDB | |
| Related UniProtKB | P08487 |
| [2] | |
| Resource | |
| Comments | PHOSPHORYLATION SITES. |
| Medline ID | 90154081 |
| PubMed ID | 1689311 |
| Journal | J Biol Chem |
| Year | 1990 |
| Volume | 265 |
| Pages | 3944-8 |
| Authors | Wahl MI, Nishibe S, Kim JW, Kim H, Rhee SG, Carpenter G |
| Title | Identification of two epidermal growth factor-sensitive tyrosine phosphorylation sites of phospholipase C-gamma in intact HSC-1 cells. |
| Related PDB | |
| Related UniProtKB | P08487 |
| [3] | |
| Resource | |
| Comments | PHOSPHORYLATION SITES. |
| Medline ID | 91208680 |
| PubMed ID | 1708307 |
| Journal | Cell |
| Year | 1991 |
| Volume | 65 |
| Pages | 435-41 |
| Authors | Kim HK, Kim JW, Zilberstein A, Margolis B, Kim JG, Schlessinger J, Rhee SG |
| Title | PDGF stimulation of inositol phospholipid hydrolysis requires PLC-gamma 1 phosphorylation on tyrosine residues 783 and 1254. |
| Related PDB | |
| Related UniProtKB | P08487 |
| [4] | |
| Resource | |
| Comments | STRUCTURE BY NMR OF SH3 DOMAIN. |
| Medline ID | 93208890 |
| PubMed ID | 7681365 |
| Journal | Cell |
| Year | 1993 |
| Volume | 72 |
| Pages | 953-60 |
| Authors | Kohda D, Hatanaka H, Odaka M, Mandiyan V, Ullrich A, Schlessinger J, Inagaki F |
| Title | Solution structure of the SH3 domain of phospholipase C-gamma. |
| Related PDB | 1hsp 1hsq 2hsp |
| Related UniProtKB | P19174 |
| [5] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7993895 |
| Journal | Biochemistry |
| Year | 1994 |
| Volume | 33 |
| Pages | 14671-8 |
| Authors | Gergel JR, McNamara DJ, Dobrusin EM, Zhu G, Saltiel AR, Miller WT |
| Title | Identification of amino acids in the N-terminal SH2 domain of phospholipase C gamma 1 important in the interaction with epidermal growth factor receptor. |
| Related PDB | |
| Related UniProtKB | |
| [6] | |
| Resource | |
| Comments | STRUCTURE BY NMR OF 663-759. |
| Medline ID | 94236690 |
| PubMed ID | 8181064 |
| Journal | Cell |
| Year | 1994 |
| Volume | 77 |
| Pages | 461-72 |
| Authors | Pascal SM, Singer AU, Gish G, Yamazaki T, Shoelson SE, Pawson T, Kay LE, Forman-Kay JD |
| Title | Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide. |
| Related PDB | 2pld 2ple |
| Related UniProtKB | P08487 |
| [7] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7843417 |
| Journal | FEBS Lett |
| Year | 1995 |
| Volume | 358 |
| Pages | 287-92 |
| Authors | Huang PS, Davis L, Huber H, Goodhart PJ, Wegrzyn RE, Oliff A, Heimbrook DC |
| Title | An SH3 domain is required for the mitogenic activity of microinjected phospholipase C-gamma 1. |
| Related PDB | |
| Related UniProtKB | |
| [8] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8524815 |
| Journal | Proc Natl Acad Sci U S A |
| Year | 1995 |
| Volume | 92 |
| Pages | 11618-22 |
| Authors | Huang X, Li Y, Tanaka K, Moore KG, Hayashi JI |
| Title |
Cloning and characterization of Lnk, |
| Related PDB | |
| Related UniProtKB | |
| [9] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7773170 |
| Journal | Protein Sci |
| Year | 1995 |
| Volume | 4 |
| Pages | 13-20 |
| Authors | MacLean D, Sefler AM, Zhu G, Decker SJ, Saltiel AR, Singh J, McNamara D, Dobrusin EM, Sawyer TK |
| Title | Differentiation of peptide molecular recognition by phospholipase C gamma-1 Src homology-2 domain and a mutant Tyr phosphatase PTP1bC215S. |
| Related PDB | |
| Related UniProtKB | |
| [10] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8660853 |
| Journal | Cell Immunol |
| Year | 1996 |
| Volume | 171 |
| Pages | 164-9 |
| Authors | Kanner SB |
| Title | Focal adhesion kinase-related fakB is regulated by the integrin LFA-1 and interacts with the SH3 domain of phospholipase C gamma 1. |
| Related PDB | |
| Related UniProtKB | |
| [11] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8941357 |
| Journal | Biochem Biophys Res Commun |
| Year | 1996 |
| Volume | 228 |
| Pages | 802-6 |
| Authors | Pei Z, Yang L, Williamson JR |
| Title | Phospholipase C-gamma 1 binds to actin-cytoskeleton via its C-terminal SH2 domain in vitro. |
| Related PDB | |
| Related UniProtKB | |
| [12] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8630067 |
| Journal | Biochem Biophys Res Commun |
| Year | 1996 |
| Volume | 222 |
| Pages | 186-93 |
| Authors | Smith MR, Liu YL, Kim SR, Bae YS, Kim CG, Kwon KS, Rhee SG, Kung HF |
| Title | PLC gamma 1 Src homology domain induces mitogenesis in quiescent NIH 3T3 fibroblasts. |
| Related PDB | |
| Related UniProtKB | |
| [13] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8598208 |
| Journal | EMBO J |
| Year | 1996 |
| Volume | 15 |
| Pages | 73-82 |
| Authors | Obermeier A, Tinhofer I, Grunicke HH, Ullrich A |
| Title | Transforming potentials of epidermal growth factor and nerve growth factor receptors inversely correlate with their phospholipase C gamma affinity and signal activation. |
| Related PDB | |
| Related UniProtKB | |
| [14] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8657103 |
| Journal | Mol Cell Biol |
| Year | 1996 |
| Volume | 16 |
| Pages | 1305-15 |
| Authors | Law CL, Chandran KA, Sidorenko SP, Clark EA |
| Title | Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk. |
| Related PDB | |
| Related UniProtKB | |
| [15] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8649391 |
| Journal | Mol Cell Biol |
| Year | 1996 |
| Volume | 16 |
| Pages | 2823-9 |
| Authors | Motto DG, Musci MA, Ross SE, Koretzky GA |
| Title | Tyrosine phosphorylation of Grb2-associated proteins correlates with phospholipase C gamma 1 activation in T cells. |
| Related PDB | |
| Related UniProtKB | |
| [16] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9712732 |
| Journal | Biochem Biophys Res Commun |
| Year | 1998 |
| Volume | 249 |
| Pages | 537-41 |
| Authors | Graham LJ, Stoica BA, Shapiro M, DeBell KE, Rellahan B, Laborda J, Bonvini E |
| Title | Sequences surrounding the Src-homology 3 domain of phospholipase Cgamma-1 increase the domain's association with Cbl. |
| Related PDB | |
| Related UniProtKB | |
| [17] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9514887 |
| Journal | Biochem Biophys Res Commun |
| Year | 1998 |
| Volume | 244 |
| Pages | 62-7 |
| Authors | Ahn SJ, Han SJ, Mo HJ, Chung JK, Hong SH, Park TK, Kim CG |
| Title | Interaction of phospholipase C gamma 1 via its COOH-terminal SRC homology 2 domain with synaptojanin. |
| Related PDB | |
| Related UniProtKB | |
| [18] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9468499 |
| Journal | J Biol Chem |
| Year | 1998 |
| Volume | 273 |
| Pages | 4465-9 |
| Authors | Bae YS, Cantley LG, Chen CS, Kim SR, Kwon KS, Rhee SG |
| Title | Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphate. |
| Related PDB | |
| Related UniProtKB | |
| [19] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9570517 |
| Journal | J Immunol |
| Year | 1998 |
| Volume | 160 |
| Pages | 1059-66 |
| Authors | Stoica B, DeBell KE, Graham L, Rellahan BL, Alava MA, Laborda J, Bonvini E |
| Title | The amino-terminal Src homology 2 domain of phospholipase C gamma 1 is essential for TCR-induced tyrosine phosphorylation of phospholipase C gamma 1. |
| Related PDB | |
| Related UniProtKB | |
| [20] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9882440 |
| Journal | Arch Biochem Biophys |
| Year | 1999 |
| Volume | 361 |
| Pages | 149-55 |
| Authors | Horstman DA, Chattopadhyay A, Carpenter G |
| Title | The influence of deletion mutations on phospholipase C-gamma 1 activity. |
| Related PDB | |
| Related UniProtKB | |
| [21] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10360750 |
| Journal | Bioorg Med Chem Lett |
| Year | 1999 |
| Volume | 9 |
| Pages | 1429-32 |
| Authors | Lee JS, Yang MY, Yeo H, Kim J, Lee HS, Ahn JS |
| Title | Uncarinic acids: phospholipase Cgamma1 inhibitors from hooks of Uncaria rhynchophylla. |
| Related PDB | |
| Related UniProtKB | |
| [22] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10202147 |
| Journal | EMBO J |
| Year | 1999 |
| Volume | 18 |
| Pages | 1832-44 |
| Authors | Williams BL, Irvin BJ, Sutor SL, Chini CC, Yacyshyn E, Bubeck Wardenburg J, Dalton M, Chan AC, Abraham RT |
| Title | Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-gamma1 and Ras activation. |
| Related PDB | |
| Related UniProtKB | |
| [23] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10350061 |
| Journal | FEBS Lett |
| Year | 1999 |
| Volume | 450 |
| Pages | 77-83 |
| Authors | Pumphrey NJ, Taylor V, Freeman S, Douglas MR, Bradfield PF, Young SP, Lord JM, Wakelam MJ, Bird IN, Salmon M, Buckley CD |
| Title |
Differential association of cytoplasmic signalling molecules SHP-1, |
| Related PDB | |
| Related UniProtKB | |
| [24] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10586033 |
| Journal | J Immunol |
| Year | 1999 |
| Volume | 163 |
| Pages | 6435-41 |
| Authors | Perez-Villar JJ, Kanner SB |
| Title | Regulated association between the tyrosine kinase Emt/Itk/Tsk and phospholipase-C gamma 1 in human T lymphocytes. |
| Related PDB | |
| Related UniProtKB | |
| [25] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10672930 |
| Journal | Mol Cells |
| Year | 1999 |
| Volume | 9 |
| Pages | 631-7 |
| Authors | Kim MJ, Si F, Kim SJ, Hong SB, Hwang JI, Lee HJ, Lee SJ, Chang JS, Lee YH, Ryu SH, Suh PG |
| Title | The SH2-SH2-SH3 domain of phospholipase C-gamma1 directly binds to translational elongation factor-1alpha. |
| Related PDB | |
| Related UniProtKB | |
| [26] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10438904 |
| Journal | J Immunol |
| Year | 1999 |
| Volume | 163 |
| Pages | 1746-9 |
| Authors | Ishiai M, Sugawara H, Kurosaki M, Kurosaki T |
| Title | Cutting edge: association of phospholipase C-gamma 2 Src homology 2 domains with BLNK is critical for B cell antigen receptor signaling. |
| Related PDB | |
| Related UniProtKB | |
| [27] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10873601 |
| Journal | Biochem Biophys Res Commun |
| Year | 2000 |
| Volume | 273 |
| Pages | 294-301 |
| Authors | Felschow DM, Civin CI, Hoehn GT |
| Title | Characterization of the tyrosine kinase Tnk1 and its binding with phospholipase C-gamma1. |
| Related PDB | |
| Related UniProtKB | |
| [28] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11094067 |
| Journal | Mol Cell Biol |
| Year | 2000 |
| Volume | 20 |
| Pages | 9149-61 |
| Authors | Irvin BJ, Williams BL, Nilson AE, Maynor HO, Abraham RT |
| Title | Pleiotropic contributions of phospholipase C-gamma1 (PLC-gamma1) to T-cell antigen receptor-mediated signaling: reconstitution studies of a PLC-gamma1-deficient Jurkat T-cell line. |
| Related PDB | |
| Related UniProtKB | |
| [29] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11015615 |
| Journal | Physiol Rev |
| Year | 2000 |
| Volume | 80 |
| Pages | 1291-335 |
| Authors | Rebecchi MJ, Pentyala SN |
| Title |
Structure, |
| Related PDB | |
| Related UniProtKB | |
| [30] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11502583 |
| Journal | Am J Physiol Cell Physiol |
| Year | 2001 |
| Volume | 281 |
| Pages | C1046-58 |
| Authors | Panebra A, Ma SX, Zhai LW, Wang XT, Rhee SG, Khurana S |
| Title | Regulation of phospholipase C-gamma(1) by the actin-regulatory protein villin. |
| Related PDB | |
| Related UniProtKB | |
| [31] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11331309 |
| Journal | J Cell Biol |
| Year | 2001 |
| Volume | 153 |
| Pages | 599-612 |
| Authors | Matsuda M, Paterson HF, Rodriguez R, Fensome AC, Ellis MV, Swann K, Katan M |
| Title | Real time fluorescence imaging of PLC gamma translocation and its interaction with the epidermal growth factor receptor. |
| Related PDB | |
| Related UniProtKB | |
| [32] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11390650 |
| Journal | Mol Cell Biol |
| Year | 2001 |
| Volume | 21 |
| Pages | 4208-18 |
| Authors | Yablonski D, Kadlecek T, Weiss A |
| Title | Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFAT. |
| Related PDB | |
| Related UniProtKB | |
| [33] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12061819 |
| Journal | Exp Cell Res |
| Year | 2002 |
| Volume | 277 |
| Pages | 86-94 |
| Authors | Tvorogov D, Carpenter G |
| Title | EGF-dependent association of phospholipase C-gamma1 with c-Cbl. |
| Related PDB | |
| Related UniProtKB | |
| [34] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12374773 |
| Journal | FASEB J |
| Year | 2002 |
| Volume | 16 |
| Pages | 1504-14 |
| Authors | Shin SY, Ko J, Chang JS, Min do S, Choi C, Bae SS, Kim MJ, Hyun DS, Kim JH, Han MY, Kim YH, Kim YS, Na DS, Suh PG, Lee YH |
| Title | Negative regulatory role of overexpression of PLC gamma 1 in the expression of early growth response 1 gene in rat 3Y1 fibroblasts. |
| Related PDB | |
| Related UniProtKB | |
| [35] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11886851 |
| Journal | J Biol Chem |
| Year | 2002 |
| Volume | 277 |
| Pages | 19697-702 |
| Authors | Chang JS, Seok H, Kwon TK, Min do S, Ahn BH, Lee YH, Suh JW, Kim JW, Iwashita S, Omori A, Ichinose S, Numata O, Seo JK, Oh YS, Suh PG |
| Title | Interaction of elongation factor-1alpha and pleckstrin homology domain of phospholipase C-gamma 1 with activating its activity. |
| Related PDB | |
| Related UniProtKB | |
| [36] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 14993410 |
| Journal | Mol Interv |
| Year | 2002 |
| Volume | 2 |
| Pages | 352-5;338 |
| Authors | Wang Z, Moran MF |
| Title | Phospholipase C-gamma1: a phospholipase and guanine nucleotide exchange factor. |
| Related PDB | |
| Related UniProtKB | |
| [37] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12226755 |
| Journal | Oncogene |
| Year | 2002 |
| Volume | 21 |
| Pages | 6520-9 |
| Authors | Piccolo E, Innominato PF, Mariggio MA, Maffucci T, Iacobelli S, Falasca M |
| Title | The mechanism involved in the regulation of phospholipase Cgamma1 activity in cell migration. |
| Related PDB | |
| Related UniProtKB | |
| [38] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11796522 |
| Journal | Endocrinology |
| Year | 2002 |
| Volume | 143 |
| Pages | 655-64 |
| Authors | Eichhorn J, Kayali AG, Resor L, Austin DA, Rose DW, Webster NJ |
| Title | PLC-gamma1 enzyme activity is required for insulin-induced DNA synthesis. |
| Related PDB | |
| Related UniProtKB | |
| Comments |
|---|
|
Although this enzyme is partially homologous to 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase from rat and human (Swiss-prot;P10688, This enzyme must be composed of the following domains: the N-terminal PH domain (CATH 2.30.29.30), two EF-hand domains (CATH 1.10.238.10), a catalytic domain (CATH 3.20.20.190), another PH domain, two SH2 domains (CATH 3.30.505.10), SH3 domain (CATH 2.30.30.40), C2 domain (CATH 2.60.40.150), and the C-terminal domain. |
| Created | Updated |
|---|---|
| 2003-08-28 | 2009-02-26 |