DB code: M00039
| CATH domain | 3.10.20.30 : Ubiquitin-like (UB roll) | Catalytic domain |
|---|---|---|
| 1.10.150.120 : DNA polymerase; domain 1 | Catalytic domain | |
| 3.90.1170.50 : Aldehyde Oxidoreductase; domain 3 | ||
| 3.30.365.10 : Aldehyde Oxidoreductase; domain 4 | ||
| 3.30.365.10 : Aldehyde Oxidoreductase; domain 4 | ||
| 3.30.365.10 : Aldehyde Oxidoreductase; domain 4 | Catalytic domain | |
| 3.30.365.10 : Aldehyde Oxidoreductase; domain 4 | Catalytic domain | |
| 3.30.43.10 : Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 2 | ||
| 3.30.390.50 : Enolase-like; domain 1 | ||
| 3.30.465.10 : Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 | Catalytic domain | |
| E.C. | 1.2.99.2 | |
| CSA | 1qj2 | |
| M-CSA | 1qj2 | |
| MACiE | M0107 | |
| CATH domain | Related DB codes (homologues) |
|---|---|
| 3.10.20.30 : Ubiquitin-like (UB roll) | M00042 M00049 |
| 3.30.43.10 : Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 2 | M00001 M00004 M00179 T00003 |
| 3.30.465.10 : Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 | T00003 |
| Uniprot Enzyme Name | UniprotKB | Protein name | Synonyms | RefSeq | Pfam |
|---|---|---|---|---|
| P19921 |
Carbon monoxide dehydrogenase small chain
|
CO dehydrogenase subunit S
CO-DH S EC 1.2.99.2 |
YP_004638432.1
(Protein)
NC_015689.1 (DNA/RNA sequence) |
PF00111
(Fer2)
PF01799 (Fer2_2) [Graphical View] |
| P19919 |
Carbon monoxide dehydrogenase large chain
|
CO dehydrogenase subunit L
CO-DH L EC 1.2.99.2 |
YP_004638433.1
(Protein)
NC_015689.1 (DNA/RNA sequence) |
PF01315
(Ald_Xan_dh_C)
PF02738 (Ald_Xan_dh_C2) [Graphical View] |
| P19920 |
Carbon monoxide dehydrogenase medium chain
|
CO dehydrogenase subunit M
CO-DH M EC 1.2.99.2 |
YP_004638431.1
(Protein)
NC_015689.1 (DNA/RNA sequence) |
PF03450
(CO_deh_flav_C)
PF00941 (FAD_binding_5) [Graphical View] |
| KEGG enzyme name |
|---|
|
carbon-monoxide dehydrogenase (acceptor)
anaerobic carbon monoxide dehydrogenase carbon monoxide oxygenase carbon-monoxide dehydrogenase carbon-monoxide:(acceptor) oxidoreductase |
| UniprotKB: Accession Number | Entry name | Activity | Subunit | Subcellular location | Cofactor |
|---|---|---|---|---|---|
| P19921 | DCMS_OLICA | CO + H(2)O + A = CO(2) + AH(2). | Dimer of heterotrimers. Each heterotrimer consists of a large, a medium and a small subunit. | Binds 2 2Fe-2S clusters. | |
| P19919 | DCML_OLICA | CO + H(2)O + A = CO(2) + AH(2). | Dimer of heterotrimers. Each heterotrimer consists of a large, a medium and a small subunit. | Binds 1 Cu(+) ion per subunit. Binds 1 Mo(6+) ion per subunit. Binds 1 molybdopterin cytosine dinucleotide (MCD) per subunit. | |
| P19920 | DCMM_OLICA | CO + H(2)O + A = CO(2) + AH(2). | Dimer of heterotrimers. Each heterotrimer consists of a large, a medium and a small subunit. | Binds 1 FAD per subunit. |
| KEGG Pathways | Map code | Pathways | E.C. |
|---|---|---|
| MAP00633 | Trinitrotoluene degradation | |
| MAP00680 | Methane metabolism |
| Compound table | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cofactors | Substrates | Products | Intermediates | ||||||||||||
| KEGG-id | L00023 | C99999 | L00006 | C00016 | C00237 | C00001 | C00028 | C00011 | C00030 | ||||||
| E.C. | |||||||||||||||
| Compound | [2Fe-2S] | Dinuclear [Cu-S-Mo(=O)OH] cluster | Molybdopterin cytosine dinucleotide | FAD | CO | H2O | Acceptor | CO2 | Reduced acceptor | ||||||
| Type | heavy metal,sulfide group | heavy metal,sulfide group | amide group,amine group,aromatic ring (with nitrogen atoms),carbohydrate,nucleotide ,sulfhydryl group | amide group,amine group,aromatic ring (only carbon atom),aromatic ring (with nitrogen atoms),carbohydrate,nucleotide | others | H2O | others | others | others | ||||||
| ChEBI |
33739 33739 |
43955 43955 |
16238 16238 |
17245 17245 |
15377 15377 |
16526 16526 |
|||||||||
| PubChem |
4369128 4369128 |
643975 643975 |
281 281 |
22247451 962 22247451 962 |
280 280 |
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| 1n5wA01 |
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Bound:FES | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n5wD01 |
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Bound:FES | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n60A01 |
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Bound:FES | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n60D01 |
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Bound:FES | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n61A01 |
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Bound:FES | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n61D01 |
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Bound:FES | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n62A01 |
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Bound:FES | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n62D01 |
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Bound:FES | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n63A01 |
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Bound:FES | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n63D01 |
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Bound:FES | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qj2A01 |
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Bound:FES | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qj2G01 |
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Bound:FES | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1zxiA01 |
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Bound:FES | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1zxiD01 |
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Bound:FES | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n5wA02 |
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Bound:FES | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n5wD02 |
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Bound:FES | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n60A02 |
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Bound:FES | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n60D02 |
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Bound:FES | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n61A02 |
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Bound:FES | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n61D02 |
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Bound:FES | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n62A02 |
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Bound:FES | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n62D02 |
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Bound:FES | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n63A02 |
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Bound:FES | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n63D02 |
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Bound:FES | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qj2A02 |
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Bound:FES | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qj2G02 |
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Bound:FES | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1zxiA02 |
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Bound:FES | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1zxiD02 |
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Bound:FES | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n5wB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n5wE01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n60B01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n60E01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n61B01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n61E01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n62B01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n62E01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n63B01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n63E01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qj2B01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qj2H01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1zxiB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1zxiE01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n5wB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n5wE02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n60B02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n60E02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n61B02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n61E02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n62B02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n62E02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n63B02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n63E02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qj2B02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qj2H02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1zxiB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1zxiE02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n5wB03 |
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Unbound | Unbound | Bound:MCN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n5wE03 |
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Unbound | Unbound | Bound:MCN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n60B03 |
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Unbound | Unbound | Bound:MCN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n60E03 |
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Unbound | Unbound | Bound:MCN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n61B03 |
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Unbound | Unbound | Bound:MCN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n61E03 |
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Unbound | Unbound | Bound:MCN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n62B03 |
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Unbound | Unbound | Bound:MCN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n62E03 |
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Unbound | Unbound | Bound:MCN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n63B03 |
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Unbound | Unbound | Bound:MCN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n63E03 |
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Unbound | Unbound | Bound:MCN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qj2B03 |
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Unbound | Unbound | Analogue:PCD | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qj2H03 |
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Unbound | Unbound | Analogue:PCD | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1zxiB03 |
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Unbound | Unbound | Bound:MCN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1zxiE03 |
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Unbound | Unbound | Bound:MCN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n5wB04 |
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Unbound | Bound:CUM (oxidized) | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n5wE04 |
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Unbound | Bound:CUM (oxidized) | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n60B04 |
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Unbound | Analogue:OMO | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n60E04 |
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Unbound | Analogue:OMO | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n61B04 |
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Unbound | Bound:CUN (reduced) | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n61E04 |
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Unbound | Bound:CUN (reduced) | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n62B04 |
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Unbound | Analogue:CUB | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:CUB | |
| 1n62E04 |
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Unbound | Analogue:CUB | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-analogue:CUB | |
| 1n63B04 |
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Unbound | Bound:CUN (reduced) | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n63E04 |
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Unbound | Bound:CUN (reduced) | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qj2B04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qj2H04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1zxiB04 |
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Unbound | Bound:CUM (oxidized) | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1zxiE04 |
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Unbound | Bound:CUM (oxidized) | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n5wB05 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n5wE05 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n60B05 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n60E05 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n61B05 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n61E05 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n62B05 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n62E05 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n63B05 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n63E05 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qj2B05 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qj2H05 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1zxiB05 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1zxiE05 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n5wC01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n5wF01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n60C01 |
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Unbound | Unbound | Unbound | Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n60F01 |
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Unbound | Unbound | Unbound | Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n61C01 |
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Unbound | Unbound | Unbound | Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n61F01 |
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Unbound | Unbound | Unbound | Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n62C01 |
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Unbound | Unbound | Unbound | Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n62F01 |
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Unbound | Unbound | Unbound | Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n63C01 |
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Unbound | Unbound | Unbound | Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n63F01 |
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Unbound | Unbound | Unbound | Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qj2C01 |
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Unbound | Unbound | Unbound | Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qj2I01 |
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Unbound | Unbound | Unbound | Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1zxiC01 |
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Unbound | Unbound | Unbound | Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1zxiF01 |
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Unbound | Unbound | Unbound | Bound:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n5wC02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n5wF02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n60C02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n60F02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n61C02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n61F02 |
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|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n62C02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n62F02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n63C02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n63F02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qj2C02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qj2I02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1zxiC02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1zxiF02 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n5wC03 |
|
|
|
|
|
Unbound | Unbound | Unbound | Analogue:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n5wF03 |
|
|
|
|
|
Unbound | Unbound | Unbound | Analogue:FAD | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n60C03 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n60F03 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n61C03 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n61F03 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n62C03 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n62F03 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n63C03 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1n63F03 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qj2C03 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1qj2I03 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1zxiC03 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1zxiF03 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| Reference for Active-site residues | ||
|---|---|---|
| resource | references | E.C. |
| Swiss-prot;P19921, P19919, P19920 & literature [3], [4], [5] | ||
| Active-site residues | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Catalytic residues | Cofactor-binding residues | Modified residues | Main-chain involved in catalysis | Comment | |||||
| 1n5wA01 |
|
|
|
|
|
CYS 42;CYS 47;CYS 50;CYS 62(2Fe-2S cluster-1 binding) | ||||
| 1n5wD01 |
|
|
|
|
|
CYS 42;CYS 47;CYS 50;CYS 62(2Fe-2S cluster-1 binding) | ||||
| 1n60A01 |
|
|
|
|
|
CYS 42;CYS 47;CYS 50;CYS 62(2Fe-2S cluster-1 binding) | ||||
| 1n60D01 |
|
|
|
|
|
CYS 42;CYS 47;CYS 50;CYS 62(2Fe-2S cluster-1 binding) | ||||
| 1n61A01 |
|
|
|
|
|
CYS 42;CYS 47;CYS 50;CYS 62(2Fe-2S cluster-1 binding) | ||||
| 1n61D01 |
|
|
|
|
|
CYS 42;CYS 47;CYS 50;CYS 62(2Fe-2S cluster-1 binding) | ||||
| 1n62A01 |
|
|
|
|
|
CYS 42;CYS 47;CYS 50;CYS 62(2Fe-2S cluster-1 binding) | ||||
| 1n62D01 |
|
|
|
|
|
CYS 42;CYS 47;CYS 50;CYS 62(2Fe-2S cluster-1 binding) | ||||
| 1n63A01 |
|
|
|
|
|
CYS 42;CYS 47;CYS 50;CYS 62(2Fe-2S cluster-1 binding) | ||||
| 1n63D01 |
|
|
|
|
|
CYS 42;CYS 47;CYS 50;CYS 62(2Fe-2S cluster-1 binding) | ||||
| 1qj2A01 |
|
|
|
|
|
CYS 42;CYS 47;CYS 50;CYS 62(2Fe-2S cluster-1 binding) | ||||
| 1qj2G01 |
|
|
|
|
|
CYS 42;CYS 47;CYS 50;CYS 62(2Fe-2S cluster-1 binding) | ||||
| 1zxiA01 |
|
|
|
|
|
CYS 42;CYS 47;CYS 50;CYS 62(2Fe-2S cluster-1 binding) | ||||
| 1zxiD01 |
|
|
|
|
|
CYS 42;CYS 47;CYS 50;CYS 62(2Fe-2S cluster-1 binding) | ||||
| 1n5wA02 |
|
|
|
|
|
CYS 102;CYS 105;CYS 137;CYS 139(2Fe-2S cluster-2 binding) | ||||
| 1n5wD02 |
|
|
|
|
|
CYS 102;CYS 105;CYS 137;CYS 139(2Fe-2S cluster-2 binding) | ||||
| 1n60A02 |
|
|
|
|
|
CYS 102;CYS 105;CYS 137;CYS 139(2Fe-2S cluster-2 binding) | ||||
| 1n60D02 |
|
|
|
|
|
CYS 102;CYS 105;CYS 137;CYS 139(2Fe-2S cluster-2 binding) | ||||
| 1n61A02 |
|
|
|
|
|
CYS 102;CYS 105;CYS 137;CYS 139(2Fe-2S cluster-2 binding) | ||||
| 1n61D02 |
|
|
|
|
|
CYS 102;CYS 105;CYS 137;CYS 139(2Fe-2S cluster-2 binding) | ||||
| 1n62A02 |
|
|
|
|
|
CYS 102;CYS 105;CYS 137;CYS 139(2Fe-2S cluster-2 binding) | ||||
| 1n62D02 |
|
|
|
|
|
CYS 102;CYS 105;CYS 137;CYS 139(2Fe-2S cluster-2 binding) | ||||
| 1n63A02 |
|
|
|
|
|
CYS 102;CYS 105;CYS 137;CYS 139(2Fe-2S cluster-2 binding) | ||||
| 1n63D02 |
|
|
|
|
|
CYS 102;CYS 105;CYS 137;CYS 139(2Fe-2S cluster-2 binding) | ||||
| 1qj2A02 |
|
|
|
|
|
CYS 102;CYS 105;CYS 137;CYS 139(2Fe-2S cluster-2 binding) | ||||
| 1qj2G02 |
|
|
|
|
|
CYS 102;CYS 105;CYS 137;CYS 139(2Fe-2S cluster-2 binding) | ||||
| 1zxiA02 |
|
|
|
|
|
CYS 102;CYS 105;CYS 137;CYS 139(2Fe-2S cluster-2 binding) | ||||
| 1zxiD02 |
|
|
|
|
|
CYS 102;CYS 105;CYS 137;CYS 139(2Fe-2S cluster-2 binding) | ||||
| 1n5wB01 |
|
|
|
|
|
|||||
| 1n5wE01 |
|
|
|
|
|
|||||
| 1n60B01 |
|
|
|
|
|
|||||
| 1n60E01 |
|
|
|
|
|
|||||
| 1n61B01 |
|
|
|
|
|
|||||
| 1n61E01 |
|
|
|
|
|
|||||
| 1n62B01 |
|
|
|
|
|
|||||
| 1n62E01 |
|
|
|
|
|
|||||
| 1n63B01 |
|
|
|
|
|
|||||
| 1n63E01 |
|
|
|
|
|
|||||
| 1qj2B01 |
|
|
|
|
|
|||||
| 1qj2H01 |
|
|
|
|
|
|||||
| 1zxiB01 |
|
|
|
|
|
|||||
| 1zxiE01 |
|
|
|
|
|
|||||
| 1n5wB02 |
|
|
|
|
|
|||||
| 1n5wE02 |
|
|
|
|
|
|||||
| 1n60B02 |
|
|
|
|
|
|||||
| 1n60E02 |
|
|
|
|
|
|||||
| 1n61B02 |
|
|
|
|
|
|||||
| 1n61E02 |
|
|
|
|
|
|||||
| 1n62B02 |
|
|
|
|
|
|||||
| 1n62E02 |
|
|
|
|
|
|||||
| 1n63B02 |
|
|
|
|
|
|||||
| 1n63E02 |
|
|
|
|
|
|||||
| 1qj2B02 |
|
|
|
|
|
|||||
| 1qj2H02 |
|
|
|
|
|
|||||
| 1zxiB02 |
|
|
|
|
|
|||||
| 1zxiE02 |
|
|
|
|
|
|||||
| 1n5wB03 |
|
|
|
|
|
|||||
| 1n5wE03 |
|
|
|
|
|
|||||
| 1n60B03 |
|
|
|
|
|
|||||
| 1n60E03 |
|
|
|
|
|
|||||
| 1n61B03 |
|
|
|
|
|
|||||
| 1n61E03 |
|
|
|
|
|
|||||
| 1n62B03 |
|
|
|
|
|
|||||
| 1n62E03 |
|
|
|
|
|
|||||
| 1n63B03 |
|
|
|
|
|
|||||
| 1n63E03 |
|
|
|
|
|
|||||
| 1qj2B03 |
|
|
|
|
|
|||||
| 1qj2H03 |
|
|
|
|
|
|||||
| 1zxiB03 |
|
|
|
|
|
|||||
| 1zxiE03 |
|
|
|
|
|
|||||
| 1n5wB04 |
|
|
|
|
|
CYS 388;GLU 763 | CYS 388(Copper binding);GLU 763(Molybdenum binding) | ARG 387 | ||
| 1n5wE04 |
|
|
|
|
|
CYS 388;GLU 763 | CYS 388(Copper binding);GLU 763(Molybdenum binding) | ARG 387 | ||
| 1n60B04 |
|
|
|
|
|
CYS 388;GLU 763 | CYS 388(Copper binding);GLU 763(Molybdenum binding) | ARG 387 | ||
| 1n60E04 |
|
|
|
|
|
CYS 388;GLU 763 | CYS 388(Copper binding);GLU 763(Molybdenum binding) | ARG 387 | ||
| 1n61B04 |
|
|
|
|
|
CYS 388;GLU 763 | CYS 388(Copper binding);GLU 763(Molybdenum binding) | ARG 387 | ||
| 1n61E04 |
|
|
|
|
|
CYS 388;GLU 763 | CYS 388(Copper binding);GLU 763(Molybdenum binding) | ARG 387 | ||
| 1n62B04 |
|
|
|
|
|
CYS 388;GLU 763 | CYS 388(Copper binding);GLU 763(Molybdenum binding) | ARG 387 | ||
| 1n62E04 |
|
|
|
|
|
CYS 388;GLU 763 | CYS 388(Copper binding);GLU 763(Molybdenum binding) | ARG 387 | ||
| 1n63B04 |
|
|
|
|
|
CYS 388;GLU 763 | CYS 388(Copper binding);GLU 763(Molybdenum binding) | ARG 387 | ||
| 1n63E04 |
|
|
|
|
|
CYS 388;GLU 763 | CYS 388(Copper binding);GLU 763(Molybdenum binding) | ARG 387 | ||
| 1qj2B04 |
|
|
|
|
|
;GLU 763 | EYS 388(Copper binding);GLU 763(Molybdenum binding) | EYS 388(Selanylated) | ARG 387 | |
| 1qj2H04 |
|
|
|
|
|
;GLU 763 | EYS 388(Copper binding);GLU 763(Molybdenum binding) | EYS 388(Selanylated) | ARG 387 | |
| 1zxiB04 |
|
|
|
|
|
CYS 388;GLU 763 | CYS 388(Copper binding);GLU 763(Molybdenum binding) | ARG 387 | ||
| 1zxiE04 |
|
|
|
|
|
CYS 388;GLU 763 | CYS 388(Copper binding);GLU 763(Molybdenum binding) | ARG 387 | ||
| 1n5wB05 |
|
|
|
|
|
GLN 240 | ||||
| 1n5wE05 |
|
|
|
|
|
GLN 240 | ||||
| 1n60B05 |
|
|
|
|
|
GLN 240 | ||||
| 1n60E05 |
|
|
|
|
|
GLN 240 | ||||
| 1n61B05 |
|
|
|
|
|
GLN 240 | ||||
| 1n61E05 |
|
|
|
|
|
GLN 240 | ||||
| 1n62B05 |
|
|
|
|
|
GLN 240 | ||||
| 1n62E05 |
|
|
|
|
|
GLN 240 | ||||
| 1n63B05 |
|
|
|
|
|
GLN 240 | ||||
| 1n63E05 |
|
|
|
|
|
GLN 240 | ||||
| 1qj2B05 |
|
|
|
|
|
GLN 240 | ||||
| 1qj2H05 |
|
|
|
|
|
GLN 240 | ||||
| 1zxiB05 |
|
|
|
|
|
GLN 240 | ||||
| 1zxiE05 |
|
|
|
|
|
GLN 240 | ||||
| 1n5wC01 |
|
|
|
|
|
|||||
| 1n5wF01 |
|
|
|
|
|
|||||
| 1n60C01 |
|
|
|
|
|
|||||
| 1n60F01 |
|
|
|
|
|
|||||
| 1n61C01 |
|
|
|
|
|
|||||
| 1n61F01 |
|
|
|
|
|
|||||
| 1n62C01 |
|
|
|
|
|
|||||
| 1n62F01 |
|
|
|
|
|
|||||
| 1n63C01 |
|
|
|
|
|
|||||
| 1n63F01 |
|
|
|
|
|
|||||
| 1qj2C01 |
|
|
|
|
|
|||||
| 1qj2I01 |
|
|
|
|
|
|||||
| 1zxiC01 |
|
|
|
|
|
|||||
| 1zxiF01 |
|
|
|
|
|
|||||
| 1n5wC02 |
|
|
|
|
|
|||||
| 1n5wF02 |
|
|
|
|
|
|||||
| 1n60C02 |
|
|
|
|
|
|||||
| 1n60F02 |
|
|
|
|
|
|||||
| 1n61C02 |
|
|
|
|
|
|||||
| 1n61F02 |
|
|
|
|
|
|||||
| 1n62C02 |
|
|
|
|
|
|||||
| 1n62F02 |
|
|
|
|
|
|||||
| 1n63C02 |
|
|
|
|
|
|||||
| 1n63F02 |
|
|
|
|
|
|||||
| 1qj2C02 |
|
|
|
|
|
|||||
| 1qj2I02 |
|
|
|
|
|
|||||
| 1zxiC02 |
|
|
|
|
|
|||||
| 1zxiF02 |
|
|
|
|
|
|||||
| 1n5wC03 |
|
|
|
|
|
|||||
| 1n5wF03 |
|
|
|
|
|
|||||
| 1n60C03 |
|
|
|
|
|
|||||
| 1n60F03 |
|
|
|
|
|
|||||
| 1n61C03 |
|
|
|
|
|
|||||
| 1n61F03 |
|
|
|
|
|
|||||
| 1n62C03 |
|
|
|
|
|
|||||
| 1n62F03 |
|
|
|
|
|
|||||
| 1n63C03 |
|
|
|
|
|
|||||
| 1n63F03 |
|
|
|
|
|
|||||
| 1qj2C03 |
|
|
|
|
|
|||||
| 1qj2I03 |
|
|
|
|
|
|||||
| 1zxiC03 |
|
|
|
|
|
|||||
| 1zxiF03 |
|
|
|
|
|
|||||
| References for Catalytic Mechanism | ||
|---|---|---|
| References | Sections | No. of steps in catalysis |
|
[1]
|
Fig.4, p.8887-8889 | |
|
[2]
|
Fig.5, p.871-875 | |
|
[3]
|
Fig.1 | |
|
[4]
|
p.1224-1228 | |
|
[5]
|
Fig.2, p.15974-15976 | |
|
[7]
|
Fig. 2, Fig. 6, Fig. 12, p.891-897 | |
| References | |
|---|---|
| [1] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) |
| Medline ID | 99362680 |
| PubMed ID | 10430865 |
| Journal | Proc Natl Acad Sci U S A |
| Year | 1999 |
| Volume | 96 |
| Pages | 8884-9 |
| Authors | Dobbek H, Gremer L, Meyer O, Huber R |
| Title |
Crystal structure and mechanism of CO dehydrogenase, |
| Related PDB | 1qj2 |
| Related UniProtKB | P19919 P19920 P19921 |
| [2] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11076018 |
| Journal | Biol Chem |
| Year | 2000 |
| Volume | 381 |
| Pages | 865-76 |
| Authors | Meyer O, Gremer L, Ferner R, Ferner M, Dobbek H, Gnida M, Meyer-Klaucke W, Huber R |
| Title |
The role of Se, |
| Related PDB | |
| Related UniProtKB | |
| [3] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10636886 |
| Journal | J Biol Chem |
| Year | 2000 |
| Volume | 275 |
| Pages | 1864-72 |
| Authors | Gremer L, Kellner S, Dobbek H, Huber R, Meyer O |
| Title |
Binding of flavin adenine dinucleotide to molybdenum-containing carbon monoxide dehydrogenase from Oligotropha carboxidovorans. |
| Related PDB | |
| Related UniProtKB | |
| [4] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10966817 |
| Journal | J Mol Biol |
| Year | 2000 |
| Volume | 301 |
| Pages | 1221-35 |
| Authors | Hanzelmann P, Dobbek H, Gremer L, Huber R, Meyer O |
| Title | The effect of intracellular molybdenum in Hydrogenophaga pseudoflava on the crystallographic structure of the seleno-molybdo-iron-sulfur flavoenzyme carbon monoxide dehydrogenase. |
| Related PDB | |
| Related UniProtKB | |
| [5] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (1.09 ANGSTROMS). |
| Medline ID | 22364130 |
| PubMed ID | 12475995 |
| Journal | Proc Natl Acad Sci U S A |
| Year | 2002 |
| Volume | 99 |
| Pages | 15971-6 |
| Authors | Dobbek H, Gremer L, Kiefersauer R, Huber R, Meyer O |
| Title | Catalysis at a dinuclear [CuSMo(==O)OH] cluster in a CO dehydrogenase resolved at 1.1-A resolution. |
| Related PDB | 1n5w 1n60 1n61 1n62 1n63 |
| Related UniProtKB | P19919 P19920 P19921 |
| [6] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12515558 |
| Journal | Biochemistry |
| Year | 2003 |
| Volume | 42 |
| Pages | 222-30 |
| Authors | Gnida M, Ferner R, Gremer L, Meyer O, Meyer-Klaucke W |
| Title | A novel binuclear [CuSMo] cluster at the active site of carbon monoxide dehydrogenase: characterization by X-ray absorption spectroscopy. |
| Related PDB | |
| Related UniProtKB | |
| [7] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 15834924 |
| Journal | J Comput Chem |
| Year | 2005 |
| Volume | 26 |
| Pages | 888-98 |
| Authors | Siegbahn PE, Shestakov AF |
| Title | Quantum chemical modeling of CO oxidation by the active site of molybdenum CO dehydrogenase. |
| Related PDB | |
| Related UniProtKB | |
| [8] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 16091936 |
| Journal | J Biol Inorg Chem |
| Year | 2005 |
| Volume | 10 |
| Pages | 518-28 |
| Authors | Resch M, Dobbek H, Meyer O |
| Title | Structural and functional reconstruction in situ of the [CuSMoO2] active site of carbon monoxide dehydrogenase from the carbon monoxide oxidizing eubacterium Oligotropha carboxidovorans. |
| Related PDB | 1zxi |
| Related UniProtKB | |
| Comments |
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This enzyme is composed of large subunits with dinuclear cluster of Mo and Cu along with Molybdopterin cytosine dinucleotide(MCD) as cofactors, Ni-containing carbon monoxide dehydrogenases and bifunctional enzymes (with acetyl-CoA synthetase) are not homologous, According to the literature [3], (A) Oxidation of CO with H2O, (B) Electron transfer from CO to S-selanylcysteine 388 (EYS 388 of 1qj2): (C) Electron transfer from S-selanylcysteine 388 (EYS 388 of 1qj2) to Molybdenum cofactor: (D) Electron transfer from Molybdenum cofactor to MCD cofactor: (E) Electron transfer from MCD cofactor to 2Fe-2S cluster-2: (F) Electron transfer from 2Fe-2S cluster-2 to 2Fe-2S cluster-1: (G) Electron transfer from 2Fe-2S cluster-1 to flavin group of FAD: (H) Electron transfer from flavin group of FAD to electron acceptor protein: |
| Created | Updated |
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| 2005-06-03 | 2009-02-26 |