RLCP 6.20.-.- :EzCatDB EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms


R 6.-.-.- : Exchange of double-bonded atoms (Schiff-base related reaction) (Reaction)

L 6.20.-.- : Schiff-base nitrogen to Carbonyl oxygen (Schiff-base deformation; hydration) (Ligand group involved)

Catalytic mechanisms

  • 6.20.7100.- : Base-Acid/Stabilizer-Modulator; Base activation of substituted group through a water; substituted group attacks on double-bonded partner atom; Stabilization of tetrahedral intermediate; Proton transfer from the substituted group to leaving group through water; Acid protonation to leaving group

  • 6.20.7800.- : Base-Acid/Modulator; Modulator-assisted base activation of substituted group; substituted group attacks on double-bonded partner atom; Acid-Base transfers proton from the substituted group to leaving group; Acid protonation to leaving group

  • 6.20.8000.- : Base-Acid/Base; Base activation of substituted group; Substituted group attacks on double-bond partner atom; Formation of tetrahedral intermediate; Covalently-bonded base deprotonates substituted group; Lone pair on substituted group attacks again on double-bond partner atom leading to bond cleavage; Acid protonation to leaving group

  • 6.20.8010.- : Base-Acid; Base activation of substituted group; substituted group attacks on double-bonded partner atom; Acid-Base transfers proton from the substituted group to leaving group; Acid protonation to leaving group

  • 6.20.28500.- : Base/Modulator/Base; Base activation of substituted group; Substituted group attacks on double-bond partner atom; Formation of tetrahedral intermediate; Covalently-bonded base deprotonates substituted group; Lone pair on nucleophile (substituted group) attacks again on double-bond partner atom

  • 6.20.29000.- : Base; Substituted group attacks on double-bond partner atom; Formation of tetrahedral intermediate; Covalently-bonded base deprotonates substituted group; Lone pair on nucleophile attacks again on double-bond partner atom

  • 6.20.85200.- : Base-Acid-Base/Modulator; Base-activated substituted group attacks on double-bond partner atom; Acid protonation to leaving group; Formation of tetrahedral intermediate; 2nd base deprotonation of substituted group; Lone pair on nucleophile attacks again on double-bond partner atom; Organic-cofactor-assisted reaction

  • 6.20.85210.- : Base/Acid/Modulator; Base-activated substituted group attacks on double-bond partner atom; Acid protonation to leaving group; Formation of tetrahedral intermediate; 2nd base deprotonation of substituted group; Lone pair on nucleophile attacks again on double-bond partner atom; Proton transfer from protonated base to deprotonated acid through cofactor/modulator and water; Organic-cofactor-assisted reaction

  • 6.20.93000.- : Base/Modulator; Base-activated substituted group attacks on double-bond partner atom; Formation of tetrahedral intermediate; Organic-cofactor-assisted deprotonation of 3rd base; 3rd base activation of lone pair on nucleophile; Lone pair on nucleophile attacks again on doulbe-bond partner atom; Organic-cofactor-assisted protonation to leaving group

    • Copyright: Nozomi Nagano, JST & CBRC-AIST
    Funded by PRESTO/Japan Science and Technology Agency (JST) (December 2001 - November 2004)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
    Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (September 2005 - September 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (October 2007 - September 2010)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2012 - March 2013)
    Supported by the commission for the Development of Artificial Gene Synthesis Technology for Creating Innovative Biomaterial from the Ministry of Economy, Trade and Industry (METI) (October 2012 - March 2016)
    Funded by the project commissioned by the New Energy and Industrial Technology Development Organization (NEDO) (April 2016 -)