DB code: U00001
| CATH domain | -.-.-.- : | |
|---|---|---|
| 1.10.1200.10 : Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein; Chain A | Catalytic domain | |
| E.C. | -.-.-.- | |
| CSA | ||
| M-CSA | ||
| MACiE | ||
| CATH domain | Related DB codes (homologues) |
|---|---|
| 1.10.1200.10 : Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein; Chain A | M00347 |
| Uniprot Enzyme Name | UniprotKB | Protein name | Synonyms | Pfam | RefSeq |
|---|---|---|---|---|
| O77077 |
Acyl carrier protein
|
None |
PF00550
(PP-binding)
[Graphical View] |
|
| O77470 |
Acyl carrier protein
|
None |
PF00550
(PP-binding)
[Graphical View] |
XP_002365498.1
(Protein)
XM_002365457.1 (DNA/RNA sequence) |
| P07854 |
Acyl carrier protein 1, chloroplastic
|
Acyl carrier protein I
ACP I |
PF00550
(PP-binding)
[Graphical View] |
| KEGG enzyme name |
|---|
|
Acyl carrier protein
ACP |
| UniprotKB: Accession Number | Entry name | Activity | Subunit | Subcellular location | Cofactor |
|---|---|---|---|---|---|
| O77077 | O77077_PLAFA | ||||
| O77470 | O77470_TOXGO | ||||
| P07854 | ACP1_SPIOL | Plastid, chloroplast. |
| KEGG Pathways | Map code | Pathways | E.C. |
|---|---|---|
| MAP00061 | Fatty acid biosynthesis | |
| MAP01056 | Biosynthesis of type II polyketide backbone | |
| MAP01057 | Biosynthesis of type II polyketide products | |
| MAP01066 | Biosynthesis of alkaloids derived from terpenoid and polyketide |
| Compound table | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Cofactors | Substrates | Products | Intermediates | ||||||
| KEGG-id | C01134 | C00229 | C00173 | ||||||
| E.C. | |||||||||
| Compound | Pantetheine 4'-phosphate | Acyl-carrier protein | Acyl-[acyl-carrier protein] | ||||||
| Type | carbohydrate,peptide/protein,phosphate group/phosphate ion,sulfhydryl group | carbohydrate,peptide/protein,phosphate group/phosphate ion,sulfhydryl group | carbohydrate,peptide/protein,phosphate group/phosphate ion,sulfide group | ||||||
| ChEBI |
4222 4222 |
||||||||
| PubChem |
115254 115254 |
||||||||
| 2fq0A00 |
|
|
|
|
|
Bound:PNS | Unbound | ||
| 2fq2A00 |
|
|
|
|
|
Bound:PNS | Unbound | ||
| 3gzlA00 |
|
|
|
|
|
Bound:PNS | Unbound | ||
| 3gzmA00 |
|
|
|
|
|
Bound:PNS | Unbound | ||
| 3gzmB00 |
|
|
|
|
|
Bound:PNS | Unbound | ||
| 2qnwA00 |
|
|
|
|
|
Unbound | Unbound | ||
| 2avaA00 |
|
|
|
|
|
Unbound | Unbound | ||
| 2fvaA00 |
|
|
|
|
|
Bound:PNS | Bound:STE | ||
| 2fveA00 |
|
|
|
|
|
Unbound | Unbound | ||
| 2fvfA00 |
|
|
|
|
|
Bound:PNS | Bound:DKA | ||
| 2xz0D00 |
|
|
|
|
|
Unbound | Unbound | ||
| 2xz1C00 |
|
|
|
|
|
Analogue:PNY | Unbound | ||
| 2xz1D00 |
|
|
|
|
|
Unbound | Unbound | ||
| Reference for Active-site residues | ||
|---|---|---|
| resource | references | E.C. |
| Active-site residues | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Catalytic residues | Cofactor-binding residues | Modified residues | Main-chain involved in catalysis | Comment | |||||
| 2fq0A00 |
|
|
|
|
|
SER 37(Phosphopantetheine binding) | ||||
| 2fq2A00 |
|
|
|
|
|
SER 37(Phosphopantetheine binding) | ||||
| 3gzlA00 |
|
|
|
|
|
SER 39(Phosphopantetheine binding) | ||||
| 3gzmA00 |
|
|
|
|
|
SER 39(Phosphopantetheine binding) | ||||
| 3gzmB00 |
|
|
|
|
|
SER 39(Phosphopantetheine binding) | ||||
| 2qnwA00 |
|
|
|
|
|
SER 41(Phosphopantetheine binding) | ||||
| 2avaA00 |
|
|
|
|
|
SER 38(Phosphopantetheine binding) | ||||
| 2fvaA00 |
|
|
|
|
|
SER 38(Phosphopantetheine binding) | ||||
| 2fveA00 |
|
|
|
|
|
SER 38(Phosphopantetheine binding) | ||||
| 2fvfA00 |
|
|
|
|
|
SER 38(Phosphopantetheine binding) | ||||
| 2xz0D00 |
|
|
|
|
|
SEP 38 | ||||
| 2xz1C00 |
|
|
|
|
|
SEP 38 | ||||
| 2xz1D00 |
|
|
|
|
|
SEP 38 | ||||
| References for Catalytic Mechanism | ||
|---|---|---|
| References | Sections | No. of steps in catalysis |
| References | |
|---|---|
| [1] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 16618110 |
| Journal | Biochemistry |
| Year | 2006 |
| Volume | 45 |
| Pages | 5217-27 |
| Authors | Zornetzer GA, Fox BG, Markley JL |
| Title | Solution structures of spinach acyl carrier protein with decanoate and stearate. |
| Related PDB | 2ava 2fva 2fve 2fvf |
| Related UniProtKB | |
| [2] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 16734426 |
| Journal | Biochemistry |
| Year | 2006 |
| Volume | 45 |
| Pages | 6904-16 |
| Authors | Sharma AK, Sharma SK, Surolia A, Surolia N, Sarma SP |
| Title | Solution structures of conformationally equilibrium forms of holo-acyl carrier protein (PfACP) from Plasmodium falciparum provides insight into the mechanism of activation of ACPs. |
| Related PDB | 2fq0 2fq2 |
| Related UniProtKB | |
| [3] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 19768685 |
| Journal | Proteins |
| Year | 2010 |
| Volume | 78 |
| Pages | 575-88 |
| Authors | Gallagher JR, Prigge ST |
| Title | Plasmodium falciparum acyl carrier protein crystal structures in disulfide-linked and reduced states and their prevalence during blood stage growth. |
| Related PDB | 3gzl 3gzm |
| Related UniProtKB | |
| Comments |
|---|
|
Although this protein is not an enzyme, C00173 Acyl-[acyl-carrier protein] C00229 [acyl-carrier-protein], C00685 3-Oxoacyl-[acyl-carrier protein] C00693 trans-2,3-Dehydroacyl-[acyl-carrier protein] C01203 Oleoyl-[acyl-carrier protein] C01209 malonyl-[acyl-carrier protein], C01271 (3R)-3-Hydroxyacyl-[acyl-carrier protein] C04088 Stearoyl-[acyl-carrier protein] C04180 3-Decanoyl-[acyl-carrier protein] C04619 (3R)-3-Hydroxydecanoyl-[acyl-carrier protein] C04688 (R)-3-Hydroxytetradecanoyl-[acyl-carrier protein] C05744 acetoacetyl-[acyl-carrier protein] C05754 trans-Dec-2-enoyl-[acyl-carrier protein] C05757 (R)-3-Hydroxydodecanoyl-[acyl-carrier protein] C05758 trans-Dodec-2-enoyl-[acyl-carrier protein] L00039 (Z)-hexadec-11-enoyl-[acyl-carrier protein] L00040 (Z)-3-oxooctadec-13-enoyl-[acyl-carrier protein] Thus, |
| Created | Updated |
|---|---|
| 2012-07-13 | 2012-07-17 |