DB code: M00021
| CATH domain | 1.-.-.- : | |
|---|---|---|
| -.-.-.- : | ||
| -.-.-.- : | ||
| 2.60.40.350 : Immunoglobulin-like | ||
| 2.60.98.10 : Tick-borne Encephalitis virus Glycoprotein; domain 1 | ||
| 3.30.67.10 : Viral Envelope Glycoprotein; domain 2 | ||
| 3.30.387.10 : Viral Envelope Glycoprotein; domain 3 | ||
| -.-.-.- : | ||
| -.-.-.- : | ||
| -.-.-.- : | ||
| 2.40.10.- : Thrombin, subunit H | ||
| 2.40.10.- : Thrombin, subunit H | ||
| 3.-.-.- : | ||
| 3.40.50.- : Rossmann fold | ||
| -.-.-.- : | ||
| -.-.-.- : | ||
| 3.40.50.- : Rossmann fold | ||
| 3.40.50.- : Rossmann fold | ||
| E.C. | 3.4.21.91 2.7.7.48 | |
| CSA | ||
| M-CSA | ||
| MACiE | ||
| CATH domain | Related DB codes (homologues) |
|---|
| Uniprot Enzyme Name | UniprotKB | Protein name | Synonyms | Contains | RefSeq | MEROPS | Pfam |
|---|---|---|---|---|---|---|
| P14336 |
Genome polyprotein
|
None |
Peptide 2k
Capsid protein C Core protein prM Peptide pr Small envelope protein M Matrix protein Envelope protein E Non-structural protein 1 (NS1) Non-structural protein 2A (NS2A) Serine protease subunit NS2B Flavivirin protease NS2B regulatory subunit Non-structural protein 2B Serine protease NS3 EC 3.4.21.91 EC 3.6.1.15 EC 3.6.4.13 Flavivirin protease NS3 catalytic subunit Non-structural protein 3 Non-structural protein 4A (NS4A) Non-structural protein 4B (NS4B) RNA-directed RNA polymerase NS5 EC 2.1.1.56 EC 2.1.1.57 EC 2.7.7.48 Non-structural protein 5 |
NP_043135.1
(Protein)
NC_001672.1 (DNA/RNA sequence) |
S07.001
(Serine)
|
PF01003
(Flavi_capsid)
PF07652 (Flavi_DEAD) PF02832 (Flavi_glycop_C) PF00869 (Flavi_glycoprot) PF01004 (Flavi_M) PF00948 (Flavi_NS1) PF01005 (Flavi_NS2A) PF01002 (Flavi_NS2B) PF01350 (Flavi_NS4A) PF01349 (Flavi_NS4B) PF00972 (Flavi_NS5) PF01570 (Flavi_propep) PF01728 (FtsJ) PF00271 (Helicase_C) PF00949 (Peptidase_S7) [Graphical View] |
| KEGG enzyme name |
|---|
|
flavivirin
(EC 3.4.21.91 ) Yellow fever virus (flavivirus) protease (EC 3.4.21.91 ) NS2B-3 proteinase (EC 3.4.21.91 ) RNA-directed RNA polymerase (EC 2.7.7.48 ) RNA nucleotidyltransferase (RNA-directed) (EC 2.7.7.48 ) RNA nucleotidyltransferase (RNA-directed) (EC 2.7.7.48 ) RNA-dependent ribonucleate nucleotidyltransferase (EC 2.7.7.48 ) 3D polymerase (EC 2.7.7.48 ) PB1 proteins (EC 2.7.7.48 ) PB2 proteins (EC 2.7.7.48 ) phage f2 replicase (EC 2.7.7.48 ) polymerase L (EC 2.7.7.48 ) Q-beta replicase (EC 2.7.7.48 ) phage f2 replicase (EC 2.7.7.48 ) ribonucleic acid replicase (EC 2.7.7.48 ) ribonucleic acid-dependent ribonucleate nucleotidyltransferase (EC 2.7.7.48 ) ribonucleic acid-dependent ribonucleic acid polymerase (EC 2.7.7.48 ) ribonucleic replicase (EC 2.7.7.48 ) ribonucleic synthetase (EC 2.7.7.48 ) RNA replicase (EC 2.7.7.48 ) RNA synthetase (EC 2.7.7.48 ) RNA transcriptase (EC 2.7.7.48 ) RNA-dependent ribonucleate nucleotidyltransferase (EC 2.7.7.48 ) RDRP (EC 2.7.7.48 ) RNA-dependent RNA polymerase (EC 2.7.7.48 ) RNA-dependent RNA replicase (EC 2.7.7.48 ) transcriptase (EC 2.7.7.48 ) |
| UniprotKB: Accession Number | Entry name | Activity | Subunit | Subcellular location | Cofactor |
|---|---|---|---|---|---|
| P14336 | POLG_TBEVW | Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala. Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). | NS3 and NS2B form a heterodimer. NS3 is the catalytic subunit, whereas NS2B strongly stimulates the latter (By similarity). | Protein C: Virion (Potential). Membrane, Single-pass membrane protein (Potential). Small envelope protein M: Virion (Potential). Membrane, Single-pass membrane protein (Potential). Envelope protein E: Virion (Potential). Membrane, Multi-pass membrane protein (Potential). Non-structural protein 4A: Membrane, Single- pass membrane protein (Potential). Non-structural protein 4B: Membrane, Multi- pass membrane protein (Potential). |
| KEGG Pathways | Map code | Pathways | E.C. |
|---|---|---|
| MAP00230 | Purine metabolism | 2.7.7.48 |
| Compound table | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Substrates | Products | Intermediates | |||||||||||
| KEGG-id | C00017 | C00201 | C00046 | C00017 | C00012 | C00013 | C00046 | ||||||
| E.C. |
3.4.21.91
|
2.7.7.48
|
2.7.7.48
|
3.4.21.91
|
3.4.21.91
|
2.7.7.48
|
2.7.7.48
|
||||||
| Compound | Protein | Nucleoside triphosphate | RNA(n) | Protein | Peptide | Pyrophosphate | RNA(n+1) | ||||||
| Type | peptide/protein | nucleotide | nucleic acids | peptide/protein | peptide/protein | phosphate group/phosphate ion | nucleic acids | ||||||
| ChEBI |
29888 29888 |
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| PubChem |
1023 21961011 1023 21961011 |
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| 1svbA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1svbA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1svbA03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| 1svbA04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | |
| Reference for Active-site residues | ||
|---|---|---|
| resource | references | E.C. |
| Active-site residues | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Catalytic residues | Cofactor-binding residues | Modified residues | Main-chain involved in catalysis | Comment | |||||
| 1svbA01 |
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| 1svbA02 |
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| 1svbA03 |
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| 1svbA04 |
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| References for Catalytic Mechanism | ||
|---|---|---|
| References | Sections | No. of steps in catalysis |
| References | |
|---|---|
| [1] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8591041 |
| Journal | Structure |
| Year | 1995 |
| Volume | 3 |
| Pages | 645-8 |
| Authors | Stuart D, Gouet P |
| Title | Viral envelope glycoproteins swing into action. |
| Related PDB | |
| Related UniProtKB | |
| [2] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 281-680. |
| Medline ID | 95272700 |
| PubMed ID | 7753193 |
| Journal | Nature |
| Year | 1995 |
| Volume | 375 |
| Pages | 291-8 |
| Authors | Rey FA, Heinz FX, Mandl C, Kunz C, Harrison SC |
| Title | The envelope glycoprotein from tick-borne encephalitis virus at 2 A resolution. |
| Related PDB | 1svb |
| Related UniProtKB | P14336 |
| [3] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11287576 |
| Journal | J Virol |
| Year | 2001 |
| Volume | 75 |
| Pages | 4268-75 |
| Authors | Allison SL, Schalich J, Stiasny K, Mandl CW, Heinz FX |
| Title | Mutational evidence for an internal fusion peptide in flavivirus envelope protein E. |
| Related PDB | |
| Related UniProtKB | |
| [4] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11264392 |
| Journal | J Virol |
| Year | 2001 |
| Volume | 75 |
| Pages | 4002-7 |
| Authors | Bhardwaj S, Holbrook M, Shope RE, Barrett AD, Watowich SJ |
| Title | Biophysical characterization and vector-specific antagonist activity of domain III of the tick-borne flavivirus envelope protein. |
| Related PDB | |
| Related UniProtKB | |
| Comments |
|---|
|
This protein (Swiss-prot;P14336) is genome polyprotein from Tick-borne encephalitis virus, However, |
| Created | Updated |
|---|---|
| 2002-10-18 | 2009-02-26 |