DB code: T00021
| CATH domain | 2.40.180.10 : Catalase HpII, Chain A, domain 1 | Catalytic domain |
|---|---|---|
| 1.10.422.10 : | ||
| 3.40.50.880 : Rossmann fold | ||
| E.C. | 1.11.1.6 | |
| CSA | 1iph | |
| M-CSA | 1iph | |
| MACiE | ||
| CATH domain | Related DB codes (homologues) |
|---|---|
| 3.40.50.880 : Rossmann fold | D00526 M00215 T00114 |
| Uniprot Enzyme Name | UniprotKB | Protein name | Synonyms | RefSeq | Pfam |
|---|---|---|---|---|
| P21179 |
Catalase HPII
|
EC
1.11.1.6
Hydroxyperoxidase II |
YP_025308.1
(Protein)
NC_000913.2 (DNA/RNA sequence) YP_489993.1 (Protein) NC_007779.1 (DNA/RNA sequence) |
PF00199
(Catalase)
PF06628 (Catalase-rel) [Graphical View] |
| KEGG enzyme name |
|---|
|
catalase
equilase caperase optidase catalase-peroxidase CAT |
| UniprotKB: Accession Number | Entry name | Activity | Subunit | Subcellular location | Cofactor |
|---|---|---|---|---|---|
| P21179 | CATE_ECOLI | 2 H(2)O(2) = O(2) + 2 H(2)O. | Homotetramer. | Cytoplasm (Probable). | Heme group. |
| KEGG Pathways | Map code | Pathways | E.C. |
|---|---|---|
| MAP00380 | Tryptophan metabolism | |
| MAP00680 | Methane metabolism |
| Compound table | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cofactors | Substrates | Products | Intermediates | |||||||||
| KEGG-id | C00032 | C00027 | C00007 | C00001 | ||||||||
| E.C. |
(oxoferryl heme, Por+-FeIV=O)
|
|||||||||||
| Compound | Heme | H2O2 | O2 | H2O | Compound I | Covalent-bonded Tyr415-His392 | Heme hydroxychlorin spirolactone + covalent-bonded Tyr415-His392 | |||||
| Type | aromatic ring (with nitrogen atoms),carboxyl group,heavy metal | others | others | H2O | ||||||||
| ChEBI |
17627 26355 17627 26355 |
16240 16240 |
15379 26689 27140 15379 26689 27140 |
15377 15377 |
||||||||
| PubChem |
22326046 784 22326046 784 |
977 977 |
22247451 962 22247451 962 |
|||||||||
| 1cf9A01 |
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Bound:HEM | Unbound | Unbound | Unbound | Unbound | ||
| 1cf9B01 |
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Bound:HEM | Unbound | Unbound | Unbound | Unbound | ||
| 1cf9C01 |
|
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Bound:HEM | Unbound | Unbound | Unbound | Unbound | ||
| 1cf9D01 |
|
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Bound:HEM | Unbound | Unbound | Unbound | Unbound | ||
| 1gg9A01 |
|
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Bound:HEM | Unbound | Unbound | Unbound | Unbound | ||
| 1gg9B01 |
|
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Bound:HEM | Unbound | Unbound | Unbound | Unbound | ||
| 1gg9C01 |
|
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|
Bound:HEM | Unbound | Unbound | Unbound | Unbound | ||
| 1gg9D01 |
|
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Bound:HEM | Unbound | Unbound | Unbound | Unbound | ||
| 1ggeA01 |
|
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Analogue:HDD | Unbound | Unbound | Unbound | Intermediate-bound:HDD-TYR_415-HIS_392 | ||
| 1ggeB01 |
|
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Analogue:HDD | Unbound | Unbound | Unbound | Intermediate-bound:HDD-TYR_415-HIS_392 | ||
| 1ggeC01 |
|
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Analogue:HDD | Unbound | Unbound | Unbound | Intermediate-bound:HDD-TYR_415-HIS_392 | ||
| 1ggeD01 |
|
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Analogue:HDD | Unbound | Unbound | Unbound | Intermediate-bound:HDD-TYR_415-HIS_392 | ||
| 1ggfA01 |
|
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Bound:HEM | Bound:2xPEO | Unbound | Unbound | Unbound | ||
| 1ggfB01 |
|
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Bound:HEM | Bound:2xPEO | Unbound | Unbound | Unbound | ||
| 1ggfC01 |
|
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Bound:HEM | Bound:2xPEO | Unbound | Unbound | Unbound | ||
| 1ggfD01 |
|
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Bound:HEM | Bound:2xPEO | Unbound | Unbound | Unbound | ||
| 1gghA01 |
|
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Bound:HEM | Unbound | Unbound | Unbound | Unbound | ||
| 1gghB01 |
|
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Bound:HEM | Unbound | Unbound | Unbound | Unbound | ||
| 1gghC01 |
|
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Bound:HEM | Unbound | Unbound | Unbound | Unbound | ||
| 1gghD01 |
|
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Bound:HEM | Unbound | Unbound | Unbound | Unbound | ||
| 1ggjA01 |
|
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|
Analogue:HDD | Unbound | Unbound | Unbound | Intermediate-bound:HDD-TYR_415-HIS_392 | ||
| 1ggjB01 |
|
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|
Analogue:HDD | Unbound | Unbound | Unbound | Intermediate-bound:HDD-TYR_415-HIS_392 | ||
| 1ggjC01 |
|
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|
Analogue:HDD | Unbound | Unbound | Unbound | Intermediate-bound:HDD-TYR_415-HIS_392 | ||
| 1ggjD01 |
|
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Analogue:HDD | Unbound | Unbound | Unbound | Intermediate-bound:HDD-TYR_415-HIS_392 | ||
| 1ggkA01 |
|
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|
|
Bound:HEM | Unbound | Unbound | Intermediate-bound:TYR_415-HIS_392 | Unbound | ||
| 1ggkB01 |
|
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Bound:HEM | Unbound | Unbound | Intermediate-bound:TYR_415-HIS_392 | Unbound | ||
| 1ggkC01 |
|
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|
|
Bound:HEM | Unbound | Unbound | Intermediate-bound:TYR_415-HIS_392 | Unbound | ||
| 1ggkD01 |
|
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|
|
Bound:HEM | Unbound | Unbound | Intermediate-bound:TYR_415-HIS_392 | Unbound | ||
| 1iphA01 |
|
|
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|
|
Bound:HEM | Unbound | Unbound | Unbound | Unbound | ||
| 1iphB01 |
|
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|
Bound:HEM | Unbound | Unbound | Unbound | Unbound | ||
| 1iphC01 |
|
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Bound:HEM | Unbound | Unbound | Unbound | Unbound | ||
| 1iphD01 |
|
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|
Bound:HEM | Unbound | Unbound | Unbound | Unbound | ||
| 1p7yA01 |
|
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|
|
Bound:HEM | Unbound | Unbound | Unbound | Unbound | ||
| 1p7yB01 |
|
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|
Bound:HEM | Unbound | Unbound | Unbound | Unbound | ||
| 1p7yC01 |
|
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|
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Bound:HEM | Unbound | Unbound | Unbound | Unbound | ||
| 1p7yD01 |
|
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Bound:HEM | Unbound | Unbound | Unbound | Unbound | ||
| 1p7zA01 |
|
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Bound:HEM | Unbound | Unbound | Unbound | Unbound | ||
| 1p7zB01 |
|
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|
|
Bound:HEM | Unbound | Unbound | Unbound | Unbound | ||
| 1p7zC01 |
|
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|
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Bound:HEM | Unbound | Unbound | Unbound | Unbound | ||
| 1p7zD01 |
|
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|
Bound:HEM | Unbound | Unbound | Unbound | Unbound | ||
| 1p80A01 |
|
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|
|
Bound:HEM | Unbound | Unbound | Unbound | Unbound | ||
| 1p80B01 |
|
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Bound:HEM | Unbound | Unbound | Unbound | Unbound | ||
| 1p80C01 |
|
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Bound:HEM | Unbound | Unbound | Unbound | Unbound | ||
| 1p80D01 |
|
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Bound:HEM | Unbound | Unbound | Unbound | Unbound | ||
| 1p81A01 |
|
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|
Analogue:HDD | Unbound | Unbound | Unbound | Intermediate-bound:HDD-TYR_415-HIS_392 | ||
| 1p81B01 |
|
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Analogue:HDD | Unbound | Unbound | Unbound | Intermediate-bound:HDD-TYR_415-HIS_392 | ||
| 1p81C01 |
|
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Analogue:HDD | Unbound | Unbound | Unbound | Intermediate-bound:HDD-TYR_415-HIS_392 | ||
| 1p81D01 |
|
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Analogue:HDD | Unbound | Unbound | Unbound | Intermediate-bound:HDD-TYR_415-HIS_392 | ||
| 1qf7A01 |
|
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Bound:HEM | Unbound | Unbound | Unbound | Unbound | ||
| 1qf7B01 |
|
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Bound:HEM | Unbound | Unbound | Unbound | Unbound | ||
| 1qf7C01 |
|
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Bound:HEM | Unbound | Unbound | Unbound | Unbound | ||
| 1qf7D01 |
|
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Bound:HEM | Unbound | Unbound | Unbound | Unbound | ||
| 1qwsA01 |
|
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Bound:HEM | Unbound | Unbound | Intermediate-bound:TYR_415-HIS_392 | Unbound | ||
| 1qwsB01 |
|
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|
Bound:HEM | Unbound | Unbound | Intermediate-bound:TYR_415-HIS_392 | Unbound | ||
| 1qwsC01 |
|
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|
|
Bound:HEM | Unbound | Unbound | Intermediate-bound:TYR_415-HIS_392 | Unbound | ||
| 1qwsD01 |
|
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|
Bound:HEM | Unbound | Unbound | Intermediate-bound:TYR_415-HIS_392 | Unbound | ||
| 1cf9A02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1cf9B02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1cf9C02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1cf9D02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1gg9A02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1gg9B02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1gg9C02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1gg9D02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1ggeA02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1ggeB02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1ggeC02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1ggeD02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1ggfA02 |
|
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Unbound | Bound:PEO | Unbound | Unbound | Unbound | ||
| 1ggfB02 |
|
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Unbound | Bound:PEO | Unbound | Unbound | Unbound | ||
| 1ggfC02 |
|
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Unbound | Bound:PEO | Unbound | Unbound | Unbound | ||
| 1ggfD02 |
|
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Unbound | Bound:PEO | Unbound | Unbound | Unbound | ||
| 1gghA02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1gghB02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1gghC02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1gghD02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1ggjA02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1ggjB02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1ggjC02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1ggjD02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1ggkA02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1ggkB02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1ggkC02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1ggkD02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1iphA02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1iphB02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1iphC02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1iphD02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1p7yA02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1p7yB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1p7yC02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1p7yD02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1p7zA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1p7zB02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1p7zC02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1p7zD02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1p80A02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1p80B02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1p80C02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1p80D02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1p81A02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1p81B02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1p81C02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1p81D02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1qf7A02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1qf7B02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1qf7C02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1qf7D02 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1qwsA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1qwsB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1qwsC02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1qwsD02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1cf9A03 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1cf9B03 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1cf9C03 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1cf9D03 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1gg9A03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1gg9B03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1gg9C03 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1gg9D03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1ggeA03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1ggeB03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1ggeC03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1ggeD03 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1ggfA03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1ggfB03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1ggfC03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1ggfD03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1gghA03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1gghB03 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1gghC03 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1gghD03 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1ggjA03 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1ggjB03 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1ggjC03 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1ggjD03 |
|
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|
Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1ggkA03 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1ggkB03 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1ggkC03 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1ggkD03 |
|
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|
|
Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1iphA03 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1iphB03 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1iphC03 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1iphD03 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1p7yA03 |
|
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|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1p7yB03 |
|
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|
|
Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1p7yC03 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1p7yD03 |
|
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|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1p7zA03 |
|
|
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|
|
Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1p7zB03 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1p7zC03 |
|
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|
|
Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1p7zD03 |
|
|
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|
|
Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1p80A03 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1p80B03 |
|
|
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|
|
Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1p80C03 |
|
|
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|
Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1p80D03 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1p81A03 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1p81B03 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1p81C03 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1p81D03 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1qf7A03 |
|
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|
Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1qf7B03 |
|
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|
Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1qf7C03 |
|
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|
Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1qf7D03 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1qwsA03 |
|
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Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1qwsB03 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1qwsC03 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | ||
| 1qwsD03 |
|
|
|
|
|
Unbound | Unbound | Unbound | Unbound | Unbound | ||
| Reference for Active-site residues | ||
|---|---|---|
| resource | references | E.C. |
| Swiss-prot;P21179 & literature [4], [5], [7], [9], [11], [13], [16] | ||
| Active-site residues | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Catalytic residues | Cofactor-binding residues | Modified residues | Main-chain involved in catalysis | Comment | |||||
| 1cf9A01 |
|
|
|
|
|
HIS 128;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant V169C | ||
| 1cf9B01 |
|
|
|
|
|
HIS 128;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant V169C | ||
| 1cf9C01 |
|
|
|
|
|
HIS 128;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant V169C | ||
| 1cf9D01 |
|
|
|
|
|
HIS 128;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant V169C | ||
| 1gg9A01 |
|
|
|
|
|
;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant H128N | ||
| 1gg9B01 |
|
|
|
|
|
;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant H128N | ||
| 1gg9C01 |
|
|
|
|
|
;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant H128N | ||
| 1gg9D01 |
|
|
|
|
|
;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant H128N | ||
| 1ggeA01 |
|
|
|
|
|
HIS 128;ASN 201;HIS 392 | TYR 415(Heme binding) | |||
| 1ggeB01 |
|
|
|
|
|
HIS 128;ASN 201;HIS 392 | TYR 415(Heme binding) | |||
| 1ggeC01 |
|
|
|
|
|
HIS 128;ASN 201;HIS 392 | TYR 415(Heme binding) | |||
| 1ggeD01 |
|
|
|
|
|
HIS 128;ASN 201;HIS 392 | TYR 415(Heme binding) | |||
| 1ggfA01 |
|
|
|
|
|
;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant H128N | ||
| 1ggfB01 |
|
|
|
|
|
;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant H128N | ||
| 1ggfC01 |
|
|
|
|
|
;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant H128N | ||
| 1ggfD01 |
|
|
|
|
|
;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant H128N | ||
| 1gghA01 |
|
|
|
|
|
;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant H128A | ||
| 1gghB01 |
|
|
|
|
|
;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant H128A | ||
| 1gghC01 |
|
|
|
|
|
;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant H128A | ||
| 1gghD01 |
|
|
|
|
|
;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant H128A | ||
| 1ggjA01 |
|
|
|
|
|
HIS 128;;HIS 392 | TYR 415(Heme binding) | mutant N201A | ||
| 1ggjB01 |
|
|
|
|
|
HIS 128;;HIS 392 | TYR 415(Heme binding) | mutant N201A | ||
| 1ggjC01 |
|
|
|
|
|
HIS 128;;HIS 392 | TYR 415(Heme binding) | mutant N201A | ||
| 1ggjD01 |
|
|
|
|
|
HIS 128;;HIS 392 | TYR 415(Heme binding) | mutant N201A | ||
| 1ggkA01 |
|
|
|
|
|
HIS 128;;HIS 392 | TYR 415(Heme binding) | mutant N201H | ||
| 1ggkB01 |
|
|
|
|
|
HIS 128;;HIS 392 | TYR 415(Heme binding) | mutant N201H | ||
| 1ggkC01 |
|
|
|
|
|
HIS 128;;HIS 392 | TYR 415(Heme binding) | mutant N201H | ||
| 1ggkD01 |
|
|
|
|
|
HIS 128;;HIS 392 | TYR 415(Heme binding) | mutant N201H | ||
| 1iphA01 |
|
|
|
|
|
HIS 128;ASN 201;HIS 392 | TYR 415(Heme binding) | |||
| 1iphB01 |
|
|
|
|
|
HIS 128;ASN 201;HIS 392 | TYR 415(Heme binding) | |||
| 1iphC01 |
|
|
|
|
|
HIS 128;ASN 201;HIS 392 | TYR 415(Heme binding) | |||
| 1iphD01 |
|
|
|
|
|
HIS 128;ASN 201;HIS 392 | TYR 415(Heme binding) | |||
| 1p7yA01 |
|
|
|
|
|
HIS 128;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant D181A | ||
| 1p7yB01 |
|
|
|
|
|
HIS 128;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant D181A | ||
| 1p7yC01 |
|
|
|
|
|
HIS 128;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant D181A | ||
| 1p7yD01 |
|
|
|
|
|
HIS 128;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant D181A | ||
| 1p7zA01 |
|
|
|
|
|
HIS 128;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant D181S | ||
| 1p7zB01 |
|
|
|
|
|
HIS 128;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant D181S | ||
| 1p7zC01 |
|
|
|
|
|
HIS 128;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant D181S | ||
| 1p7zD01 |
|
|
|
|
|
HIS 128;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant D181S | ||
| 1p80A01 |
|
|
|
|
|
HIS 128;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant D181Q | ||
| 1p80B01 |
|
|
|
|
|
HIS 128;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant D181Q | ||
| 1p80C01 |
|
|
|
|
|
HIS 128;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant D181Q | ||
| 1p80D01 |
|
|
|
|
|
HIS 128;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant D181Q | ||
| 1p81A01 |
|
|
|
|
|
HIS 128;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant D181E | ||
| 1p81B01 |
|
|
|
|
|
HIS 128;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant D181E | ||
| 1p81C01 |
|
|
|
|
|
HIS 128;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant D181E | ||
| 1p81D01 |
|
|
|
|
|
HIS 128;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant D181E | ||
| 1qf7A01 |
|
|
|
|
|
HIS 128;ASN 201; | TYR 415(Heme binding) | mutant H392Q | ||
| 1qf7B01 |
|
|
|
|
|
HIS 128;ASN 201; | TYR 415(Heme binding) | mutant H392Q | ||
| 1qf7C01 |
|
|
|
|
|
HIS 128;ASN 201; | TYR 415(Heme binding) | mutant H392Q | ||
| 1qf7D01 |
|
|
|
|
|
HIS 128;ASN 201; | TYR 415(Heme binding) | mutant H392Q | ||
| 1qwsA01 |
|
|
|
|
|
HIS 128;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant D181N | ||
| 1qwsB01 |
|
|
|
|
|
HIS 128;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant D181N | ||
| 1qwsC01 |
|
|
|
|
|
HIS 128;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant D181N | ||
| 1qwsD01 |
|
|
|
|
|
HIS 128;ASN 201;HIS 392 | TYR 415(Heme binding) | mutant D181N | ||
| 1cf9A02 |
|
|
|
|
|
|||||
| 1cf9B02 |
|
|
|
|
|
|||||
| 1cf9C02 |
|
|
|
|
|
|||||
| 1cf9D02 |
|
|
|
|
|
|||||
| 1gg9A02 |
|
|
|
|
|
|||||
| 1gg9B02 |
|
|
|
|
|
|||||
| 1gg9C02 |
|
|
|
|
|
|||||
| 1gg9D02 |
|
|
|
|
|
|||||
| 1ggeA02 |
|
|
|
|
|
|||||
| 1ggeB02 |
|
|
|
|
|
|||||
| 1ggeC02 |
|
|
|
|
|
|||||
| 1ggeD02 |
|
|
|
|
|
|||||
| 1ggfA02 |
|
|
|
|
|
|||||
| 1ggfB02 |
|
|
|
|
|
|||||
| 1ggfC02 |
|
|
|
|
|
|||||
| 1ggfD02 |
|
|
|
|
|
|||||
| 1gghA02 |
|
|
|
|
|
|||||
| 1gghB02 |
|
|
|
|
|
|||||
| 1gghC02 |
|
|
|
|
|
|||||
| 1gghD02 |
|
|
|
|
|
|||||
| 1ggjA02 |
|
|
|
|
|
|||||
| 1ggjB02 |
|
|
|
|
|
|||||
| 1ggjC02 |
|
|
|
|
|
|||||
| 1ggjD02 |
|
|
|
|
|
|||||
| 1ggkA02 |
|
|
|
|
|
|||||
| 1ggkB02 |
|
|
|
|
|
|||||
| 1ggkC02 |
|
|
|
|
|
|||||
| 1ggkD02 |
|
|
|
|
|
|||||
| 1iphA02 |
|
|
|
|
|
|||||
| 1iphB02 |
|
|
|
|
|
|||||
| 1iphC02 |
|
|
|
|
|
|||||
| 1iphD02 |
|
|
|
|
|
|||||
| 1p7yA02 |
|
|
|
|
|
|||||
| 1p7yB02 |
|
|
|
|
|
|||||
| 1p7yC02 |
|
|
|
|
|
|||||
| 1p7yD02 |
|
|
|
|
|
|||||
| 1p7zA02 |
|
|
|
|
|
|||||
| 1p7zB02 |
|
|
|
|
|
|||||
| 1p7zC02 |
|
|
|
|
|
|||||
| 1p7zD02 |
|
|
|
|
|
|||||
| 1p80A02 |
|
|
|
|
|
|||||
| 1p80B02 |
|
|
|
|
|
|||||
| 1p80C02 |
|
|
|
|
|
|||||
| 1p80D02 |
|
|
|
|
|
|||||
| 1p81A02 |
|
|
|
|
|
|||||
| 1p81B02 |
|
|
|
|
|
|||||
| 1p81C02 |
|
|
|
|
|
|||||
| 1p81D02 |
|
|
|
|
|
|||||
| 1qf7A02 |
|
|
|
|
|
|||||
| 1qf7B02 |
|
|
|
|
|
|||||
| 1qf7C02 |
|
|
|
|
|
|||||
| 1qf7D02 |
|
|
|
|
|
|||||
| 1qwsA02 |
|
|
|
|
|
|||||
| 1qwsB02 |
|
|
|
|
|
|||||
| 1qwsC02 |
|
|
|
|
|
|||||
| 1qwsD02 |
|
|
|
|
|
|||||
| 1cf9A03 |
|
|
|
|
|
|||||
| 1cf9B03 |
|
|
|
|
|
|||||
| 1cf9C03 |
|
|
|
|
|
|||||
| 1cf9D03 |
|
|
|
|
|
|||||
| 1gg9A03 |
|
|
|
|
|
|||||
| 1gg9B03 |
|
|
|
|
|
|||||
| 1gg9C03 |
|
|
|
|
|
|||||
| 1gg9D03 |
|
|
|
|
|
|||||
| 1ggeA03 |
|
|
|
|
|
|||||
| 1ggeB03 |
|
|
|
|
|
|||||
| 1ggeC03 |
|
|
|
|
|
|||||
| 1ggeD03 |
|
|
|
|
|
|||||
| 1ggfA03 |
|
|
|
|
|
|||||
| 1ggfB03 |
|
|
|
|
|
|||||
| 1ggfC03 |
|
|
|
|
|
|||||
| 1ggfD03 |
|
|
|
|
|
|||||
| 1gghA03 |
|
|
|
|
|
|||||
| 1gghB03 |
|
|
|
|
|
|||||
| 1gghC03 |
|
|
|
|
|
|||||
| 1gghD03 |
|
|
|
|
|
|||||
| 1ggjA03 |
|
|
|
|
|
|||||
| 1ggjB03 |
|
|
|
|
|
|||||
| 1ggjC03 |
|
|
|
|
|
|||||
| 1ggjD03 |
|
|
|
|
|
|||||
| 1ggkA03 |
|
|
|
|
|
|||||
| 1ggkB03 |
|
|
|
|
|
|||||
| 1ggkC03 |
|
|
|
|
|
|||||
| 1ggkD03 |
|
|
|
|
|
|||||
| 1iphA03 |
|
|
|
|
|
|||||
| 1iphB03 |
|
|
|
|
|
|||||
| 1iphC03 |
|
|
|
|
|
|||||
| 1iphD03 |
|
|
|
|
|
|||||
| 1p7yA03 |
|
|
|
|
|
|||||
| 1p7yB03 |
|
|
|
|
|
|||||
| 1p7yC03 |
|
|
|
|
|
|||||
| 1p7yD03 |
|
|
|
|
|
|||||
| 1p7zA03 |
|
|
|
|
|
|||||
| 1p7zB03 |
|
|
|
|
|
|||||
| 1p7zC03 |
|
|
|
|
|
|||||
| 1p7zD03 |
|
|
|
|
|
|||||
| 1p80A03 |
|
|
|
|
|
|||||
| 1p80B03 |
|
|
|
|
|
|||||
| 1p80C03 |
|
|
|
|
|
|||||
| 1p80D03 |
|
|
|
|
|
|||||
| 1p81A03 |
|
|
|
|
|
|||||
| 1p81B03 |
|
|
|
|
|
|||||
| 1p81C03 |
|
|
|
|
|
|||||
| 1p81D03 |
|
|
|
|
|
|||||
| 1qf7A03 |
|
|
|
|
|
|||||
| 1qf7B03 |
|
|
|
|
|
|||||
| 1qf7C03 |
|
|
|
|
|
|||||
| 1qf7D03 |
|
|
|
|
|
|||||
| 1qwsA03 |
|
|
|
|
|
|||||
| 1qwsB03 |
|
|
|
|
|
|||||
| 1qwsC03 |
|
|
|
|
|
|||||
| 1qwsD03 |
|
|
|
|
|
|||||
| References for Catalytic Mechanism | ||
|---|---|---|
| References | Sections | No. of steps in catalysis |
|
[9]
|
Fig.6, Fig.7, p.1017-1021 | |
|
[11]
|
Fig.6 | |
|
[17]
|
||
| References | |
|---|---|
| [1] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 2543292 |
| Journal | Arch Biochem Biophys |
| Year | 1989 |
| Volume | 271 |
| Pages | 323-31 |
| Authors | Schellhorn HE, Pou S, Moody C, Hassan HM |
| Title | An electron spin resonance study of oxyradical generation in superoxide dismutase- and catalase-deficient mutants of Escherichia coli K-12. |
| Related PDB | |
| Related UniProtKB | |
| [2] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 2187997 |
| Journal | J Mol Biol |
| Year | 1990 |
| Volume | 213 |
| Pages | 219-20 |
| Authors | Tormo J, Fita I, Switala J, Loewen PC |
| Title | Crystallization and preliminary X-ray diffraction analysis of catalase HPII from Escherichia coli. |
| Related PDB | |
| Related UniProtKB | |
| [3] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1662642 |
| Journal | FEBS Lett |
| Year | 1991 |
| Volume | 295 |
| Pages | 123-6 |
| Authors | Dawson JH, Bracete AM, Huff AM, Kadkhodayan S, Zeitler CM, Sono M, Chang CK, Loewen PC |
| Title |
The active site structure of E. |
| Related PDB | |
| Related UniProtKB | |
| [4] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS). |
| Medline ID | 95393020 |
| PubMed ID | 7663946 |
| Journal | Structure |
| Year | 1995 |
| Volume | 3 |
| Pages | 491-502 |
| Authors | Bravo J, Verdaguer N, Tormo J, Betzel C, Switala J, Loewen PC, Fita I |
| Title | Crystal structure of catalase HPII from Escherichia coli. |
| Related PDB | 1iph |
| Related UniProtKB | P21179 |
| [5] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8955627 |
| Journal | Gene |
| Year | 1996 |
| Volume | 179 |
| Pages | 39-44 |
| Authors | Loewen P |
| Title | Probing the structure of catalase HPII of Escherichia coli--a review. |
| Related PDB | |
| Related UniProtKB | |
| [6] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8621527 |
| Journal | J Biol Chem |
| Year | 1996 |
| Volume | 271 |
| Pages | 8863-8 |
| Authors | Murshudov GN, Grebenko AI, Barynin V, Dauter Z, Wilson KS, Vainshtein BK, Melik-Adamyan W, Bravo J, Ferran JM, Ferrer JC, Switala J, Loewen PC, Fita I |
| Title | Structure of the heme d of Penicillium vitale and Escherichia coli catalases. |
| Related PDB | |
| Related UniProtKB | |
| [7] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9185614 |
| Journal | Arch Biochem Biophys |
| Year | 1997 |
| Volume | 342 |
| Pages | 58-67 |
| Authors | Obinger C, Maj M, Nicholls P, Loewen P |
| Title |
Activity, |
| Related PDB | |
| Related UniProtKB | |
| [8] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9479449 |
| Journal | Biochimie |
| Year | 1997 |
| Volume | 79 |
| Pages | 667-71 |
| Authors | Jouve HM, Andreoletti P, Gouet P, Hajdu J, Gagnon J |
| Title | Structural analysis of compound I in hemoproteins: study on Proteus mirabilis catalase. |
| Related PDB | |
| Related UniProtKB | |
| [9] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9144772 |
| Journal | Protein Sci |
| Year | 1997 |
| Volume | 6 |
| Pages | 1016-23 |
| Authors | Bravo J, Fita I, Ferrer JC, Ens W, Hillar A, Switala J, Loewen PC |
| Title | Identification of a novel bond between a histidine and the essential tyrosine in catalase HPII of Escherichia coli. |
| Related PDB | |
| Related UniProtKB | |
| [10] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9659382 |
| Journal | Biochim Biophys Acta |
| Year | 1998 |
| Volume | 1384 |
| Pages | 209-22 |
| Authors | Maj M, Loewen P, Nicholls P |
| Title |
E. |
| Related PDB | |
| Related UniProtKB | |
| [11] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 10488114 |
| Journal | J Biol Chem |
| Year | 1999 |
| Volume | 274 |
| Pages | 27717-25 |
| Authors | Mate MJ, Sevinc MS, Hu B, Bujons J, Bravo J, Switala J, Ens W, Loewen PC, Fita I |
| Title | Mutants that alter the covalent structure of catalase hydroperoxidase II from Escherichia coli. |
| Related PDB | 1cf9 |
| Related UniProtKB | |
| [12] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS). |
| Medline ID | 99190072 |
| PubMed ID | 10091651 |
| Journal | Protein Sci |
| Year | 1999 |
| Volume | 8 |
| Pages | 490-8 |
| Authors | Sevinc MS, Mate MJ, Switala J, Fita I, Loewen PC |
| Title | Role of the lateral channel in catalase HPII of Escherichia coli. |
| Related PDB | |
| Related UniProtKB | P21179 |
| [13] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10022351 |
| Journal | Proteins |
| Year | 1999 |
| Volume | 34 |
| Pages | 155-66 |
| Authors | Bravo J, Mate MJ, Schneider T, Switala J, Wilson K, Loewen PC, Fita I |
| Title | Structure of catalase HPII from Escherichia coli at 1.9 A resolution. |
| Related PDB | |
| Related UniProtKB | |
| [14] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11275470 |
| Journal | Free Radic Biol Med |
| Year | 2001 |
| Volume | 30 |
| Pages | 709-14 |
| Authors | Brunelli L, Yermilov V, Beckman JS |
| Title | Modulation of catalase peroxidatic and catalatic activity by nitric oxide. |
| Related PDB | |
| Related UniProtKB | |
| [15] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11119647 |
| Journal | Proteins |
| Year | 2001 |
| Volume | 42 |
| Pages | 230-6 |
| Authors | Horvath MM, Grishin NV |
| Title | The C-terminal domain of HPII catalase is a member of the type I glutamine amidotransferase superfamily. |
| Related PDB | |
| Related UniProtKB | |
| [16] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (1.89 ANGSTROMS). |
| Medline ID | 21348730 |
| PubMed ID | 11455600 |
| Journal | Proteins |
| Year | 2001 |
| Volume | 44 |
| Pages | 270-81 |
| Authors | Melik-Adamyan W, Bravo J, Carpena X, Switala J, Mate MJ, Fita I, Loewen PC |
| Title | Substrate flow in catalases deduced from the crystal structures of active site variants of HPII from Escherichia coli. |
| Related PDB | 1gg9 1gge 1ggf 1ggh 1ggj 1ggk 1qf7 |
| Related UniProtKB | P21179 |
| [17] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 12777389 |
| Journal | J Biol Chem |
| Year | 2003 |
| Volume | 278 |
| Pages | 31290-6 |
| Authors | Chelikani P, Carpena X, Fita I, Loewen PC |
| Title | An electrical potential in the access channel of catalases enhances catalysis. |
| Related PDB | 1p7y 1p7z 1p80 1p81 1qws |
| Related UniProtKB | |
| [18] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 14745498 |
| Journal | Cell Mol Life Sci |
| Year | 2004 |
| Volume | 61 |
| Pages | 192-208 |
| Authors | Chelikani P, Fita I, Loewen PC |
| Title | Diversity of structures and properties among catalases. |
| Related PDB | |
| Related UniProtKB | |
| Comments |
|---|
|
There are three types of catalases, This enzyme catalyzes the following reactions: (1) Enzyme(Por-Fe(III)) + H2O2 -> Compound I(Por(+)-Fe(IV)=O) + H2O (2) Compound I(Por(+)-Fe(IV)=O) + H2O2 -> Enzyme(Por-Fe(III)) + H2O + O2 During catalysis, |
| Created | Updated |
|---|---|
| 2005-05-19 | 2009-02-26 |