DB code: M00168
| CATH domain | 3.20.20.240 : TIM Barrel | Catalytic domain |
|---|---|---|
| 3.40.50.280 : Rossmann fold | Catalytic domain | |
| 3.20.20.240 : TIM Barrel | ||
| 3.40.50.280 : Rossmann fold | ||
| 1.10.196.20 : Regulator of G-protein Signalling 4; domain 1 | ||
| E.C. | 5.4.99.2 | |
| CSA | 1req | |
| M-CSA | 1req | |
| MACiE | M0062 | |
| CATH domain | Related DB codes (homologues) |
|---|---|
| 3.20.20.240 : TIM Barrel | T00236 |
| 3.40.50.280 : Rossmann fold | M00172 T00236 |
| Uniprot Enzyme Name | UniprotKB | Protein name | Synonyms | Pfam |
|---|---|---|---|
| P11652 |
Methylmalonyl-CoA mutase small subunit
|
EC
5.4.99.2
MCB-beta |
PF01642
(MM_CoA_mutase)
[Graphical View] |
| P11653 |
Methylmalonyl-CoA mutase large subunit
|
EC
5.4.99.2
MCM-alpha |
PF02310
(B12-binding)
PF01642 (MM_CoA_mutase) [Graphical View] |
| KEGG enzyme name |
|---|
|
methylmalonyl-CoA mutase
methylmalonyl-CoA CoA-carbonyl mutase methylmalonyl coenzyme A mutase methylmalonyl coenzyme A carbonylmutase (S)-methylmalonyl-CoA mutase (R)-2-methyl-3-oxopropanoyl-CoA CoA-carbonylmutase [incorrect] |
| UniprotKB: Accession Number | Entry name | Activity | Subunit | Subcellular location | Cofactor |
|---|---|---|---|---|---|
| P11652 | MUTA_PROFR | (R)-methylmalonyl-CoA = succinyl-CoA. | Heterodimer of an alpha and a beta chain. | Adenosylcobalamin. | |
| P11653 | MUTB_PROFR | (R)-methylmalonyl-CoA = succinyl-CoA. | Heterodimer of an alpha and a beta chain. | Adenosylcobalamin. |
| KEGG Pathways | Map code | Pathways | E.C. |
|---|---|---|
| MAP00280 | Valine, leucine and isoleucine degradation | |
| MAP00640 | Propanoate metabolism |
| Compound table | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Cofactors | Substrates | Products | Intermediates | ||||||
| KEGG-id | C00194 | C01213 | C00091 | ||||||
| E.C. | |||||||||
| Compound | Cobamide coenzyme | (R)-2-Methyl-3-oxopropanoyl-CoA | Succinyl-CoA | ||||||
| Type | amide group,amine group,aromatic ring (with nitrogen atoms),carbohydrate,heavy metal,nucleoside,nucleotide | amine group,carbohydrate,carboxyl group,nucleotide ,peptide/protein,sulfide group | amine group,carbohydrate,carboxyl group,nucleotide ,peptide/protein,sulfide group | ||||||
| ChEBI |
15465 15465 |
15380 15380 |
|||||||
| PubChem |
439439 449534 439439 449534 |
439161 92133 439161 92133 |
|||||||
| 1e1cA01 |
|
|
|
|
|
Unbound | Analogue:DCA | Unbound | |
| 1e1cC01 |
|
|
|
|
|
Unbound | Analogue:DCA | Unbound | |
| 1reqA01 |
|
|
|
|
|
Unbound | Analogue:DCA-GOL | Unbound | |
| 1reqC01 |
|
|
|
|
|
Unbound | Analogue:DCA-GOL | Unbound | |
| 2reqA01 |
|
|
|
|
|
Unbound | Analogue:COA | Unbound | |
| 2reqC01 |
|
|
|
|
|
Unbound | Analogue:COA | Unbound | |
| 3reqA01 |
|
|
|
|
|
Bound:ADN | Unbound | Unbound | |
| 4reqA01 |
|
|
|
|
|
Bound:5AD | Bound:MCA | Bound:SCA | |
| 4reqC01 |
|
|
|
|
|
Bound:5AD | Bound:MCA | Bound:SCA | |
| 5reqA01 |
|
|
|
|
|
Unbound | Analogue:MCD | Analogue:SCD | |
| 5reqC01 |
|
|
|
|
|
Unbound | Analogue:MCD | Analogue:SCD | |
| 6reqA01 |
|
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|
Unbound | Unbound | Analogue:3CP | |
| 6reqC01 |
|
|
|
|
|
Unbound | Unbound | Analogue:3CP | |
| 7reqA01 |
|
|
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|
|
Unbound | Analogue:2CP | Unbound | |
| 7reqC01 |
|
|
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|
|
Unbound | Analogue:2CP | Unbound | |
| 1e1cA02 |
|
|
|
|
|
Analogue:B12 | Unbound | Unbound | |
| 1e1cC02 |
|
|
|
|
|
Analogue:B12 | Unbound | Unbound | |
| 1reqA02 |
|
|
|
|
|
Analogue:B12 | Unbound | Unbound | |
| 1reqC02 |
|
|
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|
|
Analogue:B12 | Unbound | Unbound | |
| 2reqA02 |
|
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|
|
Analogue:B12 | Unbound | Unbound | |
| 2reqC02 |
|
|
|
|
|
Analogue:B12 | Unbound | Unbound | |
| 3reqA02 |
|
|
|
|
|
Bound:B12 | Unbound | Unbound | |
| 4reqA02 |
|
|
|
|
|
Bound:B12 | Unbound | Unbound | |
| 4reqC02 |
|
|
|
|
|
Bound:B12 | Unbound | Unbound | |
| 5reqA02 |
|
|
|
|
|
Analogue:B12 | Unbound | Unbound | |
| 5reqC02 |
|
|
|
|
|
Analogue:B12 | Unbound | Unbound | |
| 6reqA02 |
|
|
|
|
|
Analogue:B12 | Unbound | Unbound | |
| 6reqC02 |
|
|
|
|
|
Analogue:B12 | Unbound | Unbound | |
| 7reqA02 |
|
|
|
|
|
Analogue:B12 | Unbound | Unbound | |
| 7reqC02 |
|
|
|
|
|
Analogue:B12 | Unbound | Unbound | |
| 1e1cB01 |
|
|
|
|
|
Unbound | Unbound | Unbound | |
| 1e1cD01 |
|
|
|
|
|
Unbound | Unbound | Unbound | |
| 1reqB01 |
|
|
|
|
|
Unbound | Unbound | Unbound | |
| 1reqD01 |
|
|
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|
|
Unbound | Unbound | Unbound | |
| 2reqB01 |
|
|
|
|
|
Unbound | Unbound | Unbound | |
| 2reqD01 |
|
|
|
|
|
Unbound | Unbound | Unbound | |
| 3reqB01 |
|
|
|
|
|
Unbound | Unbound | Unbound | |
| 4reqB01 |
|
|
|
|
|
Unbound | Unbound | Unbound | |
| 4reqD01 |
|
|
|
|
|
Unbound | Unbound | Unbound | |
| 5reqB01 |
|
|
|
|
|
Unbound | Unbound | Unbound | |
| 5reqD01 |
|
|
|
|
|
Unbound | Unbound | Unbound | |
| 6reqB01 |
|
|
|
|
|
Unbound | Unbound | Unbound | |
| 6reqD01 |
|
|
|
|
|
Unbound | Unbound | Unbound | |
| 7reqB01 |
|
|
|
|
|
Unbound | Unbound | Unbound | |
| 7reqD01 |
|
|
|
|
|
Unbound | Unbound | Unbound | |
| 1e1cB02 |
|
|
|
|
|
Unbound | Unbound | Unbound | |
| 1e1cD02 |
|
|
|
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|
Unbound | Unbound | Unbound | |
| 1reqB02 |
|
|
|
|
|
Unbound | Unbound | Unbound | |
| 1reqD02 |
|
|
|
|
|
Unbound | Unbound | Unbound | |
| 2reqB02 |
|
|
|
|
|
Unbound | Unbound | Unbound | |
| 2reqD02 |
|
|
|
|
|
Unbound | Unbound | Unbound | |
| 3reqB02 |
|
|
|
|
|
Unbound | Unbound | Unbound | |
| 4reqB02 |
|
|
|
|
|
Unbound | Unbound | Unbound | |
| 4reqD02 |
|
|
|
|
|
Unbound | Unbound | Unbound | |
| 5reqB02 |
|
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|
|
|
Unbound | Unbound | Unbound | |
| 5reqD02 |
|
|
|
|
|
Unbound | Unbound | Unbound | |
| 6reqB02 |
|
|
|
|
|
Unbound | Unbound | Unbound | |
| 6reqD02 |
|
|
|
|
|
Unbound | Unbound | Unbound | |
| 7reqB02 |
|
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|
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Unbound | Unbound | Unbound | |
| 7reqD02 |
|
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|
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Unbound | Unbound | Unbound | |
| 1e1cB03 |
|
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Unbound | Unbound | Unbound | |
| 1e1cD03 |
|
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Unbound | Unbound | Unbound | |
| 1reqB03 |
|
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Unbound | Unbound | Unbound | |
| 1reqD03 |
|
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|
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Unbound | Unbound | Unbound | |
| 2reqB03 |
|
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|
|
Unbound | Unbound | Unbound | |
| 2reqD03 |
|
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|
Unbound | Unbound | Unbound | |
| 3reqB03 |
|
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|
Unbound | Unbound | Unbound | |
| 4reqB03 |
|
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Unbound | Unbound | Unbound | |
| 4reqD03 |
|
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Unbound | Unbound | Unbound | |
| 5reqB03 |
|
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Unbound | Unbound | Unbound | |
| 5reqD03 |
|
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Unbound | Unbound | Unbound | |
| 6reqB03 |
|
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Unbound | Unbound | Unbound | |
| 6reqD03 |
|
|
|
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|
Unbound | Unbound | Unbound | |
| 7reqB03 |
|
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|
|
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Unbound | Unbound | Unbound | |
| 7reqD03 |
|
|
|
|
|
Unbound | Unbound | Unbound | |
| Reference for Active-site residues | ||
|---|---|---|
| resource | references | E.C. |
| literature [13], [17], [19] | ||
| Active-site residues | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Catalytic residues | Cofactor-binding residues | Modified residues | Main-chain involved in catalysis | Comment | |||||
| 1e1cA01 |
|
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|
TYR 89; | mutant H244A | |||
| 1e1cC01 |
|
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TYR 89; | mutant H244A | |||
| 1reqA01 |
|
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TYR 89;HIS 244 | ||||
| 1reqC01 |
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TYR 89;HIS 244 | ||||
| 2reqA01 |
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TYR 89;HIS 244 | ||||
| 2reqC01 |
|
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TYR 89;HIS 244 | ||||
| 3reqA01 |
|
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TYR 89;HIS 244 | ||||
| 4reqA01 |
|
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TYR 89;HIS 244 | ||||
| 4reqC01 |
|
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TYR 89;HIS 244 | ||||
| 5reqA01 |
|
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;HIS 244 | mutant Y89F | |||
| 5reqC01 |
|
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;HIS 244 | mutant Y89F | |||
| 6reqA01 |
|
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TYR 89;HIS 244 | ||||
| 6reqC01 |
|
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TYR 89;HIS 244 | ||||
| 7reqA01 |
|
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TYR 89;HIS 244 | ||||
| 7reqC01 |
|
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TYR 89;HIS 244 | ||||
| 1e1cA02 |
|
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LYS 604;ASP 608 | HIS 610(Cobamide coenzyme binding) | |||
| 1e1cC02 |
|
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LYS 604;ASP 608 | HIS 610(Cobamide coenzyme binding) | |||
| 1reqA02 |
|
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LYS 604;ASP 608 | HIS 610(Cobamide coenzyme binding) | |||
| 1reqC02 |
|
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LYS 604;ASP 608 | HIS 610(Cobamide coenzyme binding) | |||
| 2reqA02 |
|
|
|
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LYS 604;ASP 608 | HIS 610(Cobamide coenzyme binding) | |||
| 2reqC02 |
|
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|
|
LYS 604;ASP 608 | HIS 610(Cobamide coenzyme binding) | |||
| 3reqA02 |
|
|
|
|
|
LYS 604;ASP 608 | HIS 610(Cobamide coenzyme binding) | |||
| 4reqA02 |
|
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|
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LYS 604;ASP 608 | HIS 610(Cobamide coenzyme binding) | |||
| 4reqC02 |
|
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LYS 604;ASP 608 | HIS 610(Cobamide coenzyme binding) | |||
| 5reqA02 |
|
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|
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LYS 604;ASP 608 | HIS 610(Cobamide coenzyme binding) | |||
| 5reqC02 |
|
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|
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LYS 604;ASP 608 | HIS 610(Cobamide coenzyme binding) | |||
| 6reqA02 |
|
|
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LYS 604;ASP 608 | HIS 610(Cobamide coenzyme binding) | |||
| 6reqC02 |
|
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|
|
LYS 604;ASP 608 | HIS 610(Cobamide coenzyme binding) | |||
| 7reqA02 |
|
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|
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LYS 604;ASP 608 | HIS 610(Cobamide coenzyme binding) | |||
| 7reqC02 |
|
|
|
|
|
LYS 604;ASP 608 | HIS 610(Cobamide coenzyme binding) | |||
| 1e1cB01 |
|
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|||||
| 1e1cD01 |
|
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|||||
| 1reqB01 |
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| 1reqD01 |
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| 2reqB01 |
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|||||
| 2reqD01 |
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| 3reqB01 |
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| 4reqB01 |
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| 4reqD01 |
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| 5reqB01 |
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| 5reqD01 |
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| 6reqB01 |
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|||||
| 6reqD01 |
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| 7reqB01 |
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|||||
| 7reqD01 |
|
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|||||
| 1e1cB02 |
|
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|||||
| 1e1cD02 |
|
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| 1reqB02 |
|
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| 1reqD02 |
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| 2reqB02 |
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| 2reqD02 |
|
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| 3reqB02 |
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| 4reqB02 |
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| 4reqD02 |
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| 5reqB02 |
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| 5reqD02 |
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| 6reqB02 |
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| 6reqD02 |
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| 7reqB02 |
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| 7reqD02 |
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| 1e1cB03 |
|
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| 1e1cD03 |
|
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| 1reqB03 |
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| 1reqD03 |
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| 2reqB03 |
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| 2reqD03 |
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| 3reqB03 |
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| 4reqB03 |
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| 4reqD03 |
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| 5reqB03 |
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| 5reqD03 |
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| 6reqB03 |
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| 6reqD03 |
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| 7reqB03 |
|
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|||||
| 7reqD03 |
|
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| References for Catalytic Mechanism | ||
|---|---|---|
| References | Sections | No. of steps in catalysis |
|
[1]
|
Fig.11, p.552-553 | |
|
[2]
|
Scheme 1 | |
|
[3]
|
Scheme 1 | |
|
[6]
|
Scheme 1, p.9297-9299 | |
|
[9]
|
Fig.1, p.345-347 | |
|
[10]
|
Fig.16, Fig.16, p.299-302 | |
|
[12]
|
Fig.1, p.293-296 | |
|
[13]
|
Fig.1, p.14390-14392 | |
|
[14]
|
p.717-718 | |
|
[16]
|
Fig.4, p.8002-8004 | |
|
[17]
|
Scheme II, p.32735-32737 | |
|
[18]
|
Scheme 1 | |
|
[19]
|
p.9217-9220 | |
|
[20]
|
Scheme 1, p.919-922 | |
|
[22]
|
Fig.1, p.621-624 | |
|
[23]
|
||
|
[24]
|
Scheme 3, p.2088-2091 | |
|
[26]
|
Fig.1, Fig.2, p.1075-1078 | |
|
[27]
|
Fig.1, p.5431 | |
|
[28]
|
Scheme 1, p.8410-8411 | |
|
[29]
|
Fig.2, p.8179-8180 | |
| References | |
|---|---|
| [1] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 2870921 |
| Journal | Eur J Biochem |
| Year | 1986 |
| Volume | 156 |
| Pages | 545-54 |
| Authors | Wolfle K, Michenfelder M, Konig A, Hull WE, Retey J |
| Title |
On the mechanism of action of methylmalonyl-CoA mutase. |
| Related PDB | |
| Related UniProtKB | |
| [2] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7902085 |
| Journal | Biochem J |
| Year | 1993 |
| Volume | 295 |
| Pages | 387-92 |
| Authors | Keep NH, Smith GA, Evans MC, Diakun GP, Leadlay PF |
| Title | The synthetic substrate succinyl(carbadethia)-CoA generates cob(II)alamin on adenosylcobalamin-dependent methylmalonyl-CoA mutase. |
| Related PDB | |
| Related UniProtKB | |
| [3] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7957226 |
| Journal | Eur J Biochem |
| Year | 1994 |
| Volume | 225 |
| Pages | 891-6 |
| Authors | Zhao Y, Abend A, Kunz M, Such P, Retey J |
| Title |
Electron paramagnetic resonance studies of the methylmalonyl-CoA mutase reaction. |
| Related PDB | |
| Related UniProtKB | |
| [4] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7578009 |
| Journal | Biochemistry |
| Year | 1995 |
| Volume | 34 |
| Pages | 14125-30 |
| Authors | Calafat AM, Taoka S, Puckett JM Jr, Semerad C, Yan H, Luo L, Chen H, Banerjee R, Marzilli LG |
| Title | Structural and electronic similarity but functional difference in methylmalonyl-CoA mutase between coenzyme B12 and the analog 2',5'-dideoxyadenosylcobalamin. |
| Related PDB | |
| Related UniProtKB | |
| [5] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8722121 |
| Journal | Biofactors |
| Year | 1995 |
| Volume | 5 |
| Pages | 83-6 |
| Authors | Padmakumar R, Banerjee R |
| Title | A carbon-skeleton walk: a novel double rearrangement of glutaryl-CoA catalyzed by the human methylmalonyl-CoA mutase. |
| Related PDB | |
| Related UniProtKB | |
| [6] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7721850 |
| Journal | J Biol Chem |
| Year | 1995 |
| Volume | 270 |
| Pages | 9295-300 |
| Authors | Padmakumar R, Banerjee R |
| Title | Evidence from electron paramagnetic resonance spectroscopy of the participation of radical intermediates in the reaction catalyzed by methylmalonyl-coenzyme A mutase. |
| Related PDB | |
| Related UniProtKB | |
| [7] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8599754 |
| Journal | Nat Struct Biol |
| Year | 1996 |
| Volume | 3 |
| Pages | 316 |
| Authors | Riddihough G |
| Title |
Picture story. |
| Related PDB | |
| Related UniProtKB | |
| [8] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8643613 |
| Journal | Proc Natl Acad Sci U S A |
| Year | 1996 |
| Volume | 93 |
| Pages | 5550-5 |
| Authors | Drennan CL, Matthews RG, Rosenblatt DS, Ledley FD, Fenton WA, Ludwig ML |
| Title | Molecular basis for dysfunction of some mutant forms of methylmalonyl-CoA mutase: deductions from the structure of methionine synthase. |
| Related PDB | |
| Related UniProtKB | |
| [9] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS). |
| Medline ID | 96398619 |
| PubMed ID | 8805541 |
| Journal | Structure |
| Year | 1996 |
| Volume | 4 |
| Pages | 339-50 |
| Authors | Mancia F, Keep NH, Nakagawa A, Leadlay PF, McSweeney S, Rasmussen B, Bosecke P, Diat O, Evans PR |
| Title | How coenzyme B12 radicals are generated: the crystal structure of methylmalonyl-coenzyme A mutase at 2 A resolution. |
| Related PDB | 1req |
| Related UniProtKB | P11652 P11653 |
| [10] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9242908 |
| Journal | Annu Rev Biochem |
| Year | 1997 |
| Volume | 66 |
| Pages | 269-313 |
| Authors | Ludwig ML, Matthews RG |
| Title | Structure-based perspectives on B12-dependent enzymes. |
| Related PDB | |
| Related UniProtKB | |
| [11] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9363770 |
| Journal | Eur J Biochem |
| Year | 1997 |
| Volume | 249 |
| Pages | 180-6 |
| Authors | Abend A, Illich V, Retey J |
| Title | Further insights into the mechanism of action of methylmalonyl-CoA mutase by electron paramagnetic resonance studies. |
| Related PDB | |
| Related UniProtKB | |
| [12] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9765867 |
| Journal | Biochem Soc Trans |
| Year | 1998 |
| Volume | 26 |
| Pages | 293-8 |
| Authors | Thoma NH, Leadlay PF |
| Title | Mechanistic and structural studies on methylmalonyl-CoA mutase. |
| Related PDB | |
| Related UniProtKB | |
| [13] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 9772164 |
| Journal | Biochemistry |
| Year | 1998 |
| Volume | 37 |
| Pages | 14386-93 |
| Authors | Thoma NH, Meier TW, Evans PR, Leadlay PF |
| Title | Stabilization of radical intermediates by an active-site tyrosine residue in methylmalonyl-CoA mutase. |
| Related PDB | 5req |
| Related UniProtKB | |
| [14] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS). |
| Medline ID | 98322359 |
| PubMed ID | 9655823 |
| Journal | Structure |
| Year | 1998 |
| Volume | 6 |
| Pages | 711-20 |
| Authors | Mancia F, Evans PR |
| Title | Conformational changes on substrate binding to methylmalonyl CoA mutase and new insights into the free radical mechanism. |
| Related PDB | 2req 3req |
| Related UniProtKB | P11652 P11653 |
| [15] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10563814 |
| Journal | Biochemistry |
| Year | 1999 |
| Volume | 38 |
| Pages | 15287-94 |
| Authors | Chowdhury S, Banerjee R |
| Title | Role of the dimethylbenzimidazole tail in the reaction catalyzed by coenzyme B12-dependent methylmalonyl-CoA mutase. |
| Related PDB | |
| Related UniProtKB | |
| [16] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 10387043 |
| Journal | Biochemistry |
| Year | 1999 |
| Volume | 38 |
| Pages | 7999-8005 |
| Authors | Mancia F, Smith GA, Evans PR |
| Title | Crystal structure of substrate complexes of methylmalonyl-CoA mutase. |
| Related PDB | 4req 6req 7req |
| Related UniProtKB | |
| [17] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10551831 |
| Journal | J Biol Chem |
| Year | 1999 |
| Volume | 274 |
| Pages | 32733-7 |
| Authors | Maiti N, Widjaja L, Banerjee R |
| Title | Proton transfer from histidine 244 may facilitate the 1,2 rearrangement reaction in coenzyme B(12)-dependent methylmalonyl-CoA mutase. |
| Related PDB | |
| Related UniProtKB | |
| [18] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10891081 |
| Journal | Biochemistry |
| Year | 2000 |
| Volume | 39 |
| Pages | 7998-8006 |
| Authors | Chowdhury S, Banerjee R |
| Title | Thermodynamic and kinetic characterization of Co-C bond homolysis catalyzed by coenzyme B(12)-dependent methylmalonyl-CoA mutase. |
| Related PDB | |
| Related UniProtKB | |
| [19] | |
| Resource | |
| Comments | X-ray crystallography |
| Medline ID | |
| PubMed ID | 10924114 |
| Journal | Biochemistry |
| Year | 2000 |
| Volume | 39 |
| Pages | 9213-21 |
| Authors | Thoma NH, Evans PR, Leadlay PF |
| Title | Protection of radical intermediates at the active site of adenosylcobalamin-dependent methylmalonyl-CoA mutase. |
| Related PDB | 1e1c |
| Related UniProtKB | |
| [20] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11948881 |
| Journal | Chembiochem |
| Year | 2001 |
| Volume | 2 |
| Pages | 919-22 |
| Authors | Wetmore SD, Smith DM, Radom L |
| Title | Catalysis by mutants of methylmalonyl-CoA mutase: a theoretical rationalization for a change in the rate-determining step. |
| Related PDB | |
| Related UniProtKB | |
| [21] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11031263 |
| Journal | J Biol Chem |
| Year | 2001 |
| Volume | 276 |
| Pages | 1015-9 |
| Authors | Chowdhury S, Thomas MG, Escalante-Semerena JC, Banerjee R |
| Title | The coenzyme b12 analog 5'-deoxyadenosylcobinamide-gdp supports catalysis by methylmalonyl-coa mutase in the absence of trans-ligand coordination. |
| Related PDB | |
| Related UniProtKB | |
| [22] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12196149 |
| Journal | Biochem Soc Trans |
| Year | 2002 |
| Volume | 30 |
| Pages | 621-4 |
| Authors | Banerjee R, Vlasie M |
| Title | Controlling the reactivity of radical intermediates by coenzyme B(12)-dependent methylmalonyl-CoA mutase. |
| Related PDB | |
| Related UniProtKB | |
| [23] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11893736 |
| Journal | J Biol Chem |
| Year | 2002 |
| Volume | 277 |
| Pages | 18523-7 |
| Authors | Vlasie M, Chowdhury S, Banerjee R |
| Title | Importance of the histidine ligand to coenzyme B12 in the reaction catalyzed by methylmalonyl-CoA mutase. |
| Related PDB | |
| Related UniProtKB | |
| [24] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12797824 |
| Journal | Chem Rev |
| Year | 2003 |
| Volume | 103 |
| Pages | 2083-94 |
| Authors | Banerjee R |
| Title | Radical carbon skeleton rearrangements: catalysis by coenzyme B12-dependent mutases. |
| Related PDB | |
| Related UniProtKB | |
| [25] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12569457 |
| Journal | Chemistry |
| Year | 2003 |
| Volume | 9 |
| Pages | 652-60 |
| Authors | Weigl U, Heimberger M, Pierik AJ, Retey J |
| Title |
Synthesis of enantiomerically-pure [13C]aristeromycylcobalamin and its reactivity in dioldehydratase, |
| Related PDB | |
| Related UniProtKB | |
| [26] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12537507 |
| Journal | J Am Chem Soc |
| Year | 2003 |
| Volume | 125 |
| Pages | 1072-8 |
| Authors | Loferer MJ, Webb BM, Grant GH, Liedl KR |
| Title | Energetic and stereochemical effects of the protein environment on substrate: a theoretical study of methylmalonyl-CoA mutase. |
| Related PDB | |
| Related UniProtKB | |
| [27] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12720457 |
| Journal | J Am Chem Soc |
| Year | 2003 |
| Volume | 125 |
| Pages | 5431-5 |
| Authors | Vlasie MD, Banerjee R |
| Title | Tyrosine 89 accelerates Co-carbon bond homolysis in methylmalonyl-CoA mutase. |
| Related PDB | |
| Related UniProtKB | |
| [28] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 15222752 |
| Journal | Biochemistry |
| Year | 2004 |
| Volume | 43 |
| Pages | 8410-7 |
| Authors | Vlasie MD, Banerjee R |
| Title | When a spectator turns killer: suicidal electron transfer from cobalamin in methylmalonyl-CoA mutase. |
| Related PDB | |
| Related UniProtKB | |
| [29] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 15225058 |
| Journal | J Am Chem Soc |
| Year | 2004 |
| Volume | 126 |
| Pages | 8167-80 |
| Authors | Brooks AJ, Vlasie M, Banerjee R, Brunold TC |
| Title | Spectroscopic and computational studies on the adenosylcobalamin-dependent methylmalonyl-CoA mutase: evaluation of enzymatic contributions to Co-C bond activation in the Co3+ ground state. |
| Related PDB | |
| Related UniProtKB | |
| [30] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 15113202 |
| Journal | J Am Chem Soc |
| Year | 2004 |
| Volume | 126 |
| Pages | 5368-9 |
| Authors | Daublain P, Horner JH, Kuznetsov A, Newcomb M |
| Title | Solvent polarity effects and limited acid catalysis in rearrangements of model radicals for the methylmalonyl-CoA mutase- and isobutyryl-CoA mutase-catalyzed isomerization reactions. |
| Related PDB | |
| Related UniProtKB | |
| Comments |
|---|
|
This enzyme catalyzes radical reactions.
|
| Created | Updated |
|---|---|
| 2005-05-27 | 2009-02-26 |