DB code: M00031
| CATH domain | 3.40.50.220 : Rossmann fold | |
|---|---|---|
| 3.40.640.10 : Aspartate Aminotransferase; domain 2 | Catalytic domain | |
| 3.90.1150.10 : Aspartate Aminotransferase, domain 1 | ||
| 3.90.100.10 : Ornithine Decarboxylase; Chain A, domain 4 | ||
| E.C. | 4.1.1.17 | |
| CSA | 1ord | |
| M-CSA | 1ord | |
| MACiE | ||
| CATH domain | Related DB codes (homologues) |
|---|---|
| 3.40.640.10 : Aspartate Aminotransferase; domain 2 | D00085 D00092 D00101 D00102 D00103 D00104 D00107 D00108 D00109 D00255 D00257 D00258 D00265 D00269 D00515 D00279 |
| 3.90.1150.10 : Aspartate Aminotransferase, domain 1 | D00085 D00092 D00101 D00102 D00103 D00104 D00107 D00108 D00109 D00255 D00257 D00258 D00265 D00269 D00515 D00279 |
| Uniprot Enzyme Name | UniprotKB | Protein name | Synonyms | Pfam |
|---|---|---|---|
| P43099 |
Ornithine decarboxylase, inducible
|
ODC
EC 4.1.1.17 |
PF01276
(OKR_DC_1)
PF03711 (OKR_DC_1_C) PF03709 (OKR_DC_1_N) [Graphical View] |
| KEGG enzyme name |
|---|
|
ornithine decarboxylase
SpeC L-ornithine carboxy-lyase |
| UniprotKB: Accession Number | Entry name | Activity | Subunit | Subcellular location | Cofactor |
|---|---|---|---|---|---|
| P43099 | DCOR_LACS3 | L-ornithine = putrescine + CO(2). | Dodecamer. | Pyridoxal phosphate. |
| KEGG Pathways | Map code | Pathways | E.C. |
|---|---|---|
| MAP00220 | Urea cycle and metabolism of amino groups | |
| MAP00480 | Glutathione metabolism |
| Compound table | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cofactors | Substrates | Products | Intermediates | |||||||
| KEGG-id | C00018 | C00077 | C00134 | C00011 | ||||||
| E.C. | ||||||||||
| Compound | Pyridoxal phosphate | L-Ornithine | Putrescine | CO2 | ||||||
| Type | aromatic ring (with nitrogen atoms),phosphate group/phosphate ion | amino acids,amine group,lipid | amine group,lipid | others | ||||||
| ChEBI |
18405 18405 |
15729 15729 |
17148 17148 |
16526 16526 |
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| PubChem |
1051 1051 |
6262 88747248 6262 88747248 |
1045 1045 |
280 280 |
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| 1c4kA01 |
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Unbound | Unbound | Unbound | Unbound | |
| 1ordA01 |
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Unbound | Unbound | Unbound | Unbound | |
| 1ordB01 |
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Unbound | Unbound | Unbound | Unbound | |
| 1c4kA02 |
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Bound:PLP | Unbound | Unbound | Unbound | |
| 1ordA02 |
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Bound:PLP | Unbound | Unbound | Unbound | |
| 1ordB02 |
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Bound:PLP | Unbound | Unbound | Unbound | |
| 1c4kA03 |
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Unbound | Unbound | Unbound | Unbound | |
| 1ordA03 |
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Unbound | Unbound | Unbound | Unbound | |
| 1ordB03 |
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Unbound | Unbound | Unbound | Unbound | |
| 1c4kA04 |
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Unbound | Unbound | Unbound | Unbound | |
| 1ordA04 |
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Unbound | Unbound | Unbound | Unbound | |
| 1ordB04 |
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Unbound | Unbound | Unbound | Unbound | |
| Reference for Active-site residues | ||
|---|---|---|
| resource | references | E.C. |
| literature [3], [4] | ||
| Active-site residues | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Catalytic residues | Cofactor-binding residues | Modified residues | Main-chain involved in catalysis | Comment | |||||
| 1c4kA01 |
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| 1ordA01 |
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| 1ordB01 |
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| 1c4kA02 |
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HIS 223;ASP 316;HIS 354;LYS 355 | LYS 355(PLP binding) | utant G121Y | ||
| 1ordA02 |
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HIS 223;ASP 316;HIS 354;LYS 355 | LYS 355(PLP binding) | |||
| 1ordB02 |
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HIS 223;ASP 316;HIS 354;LYS 355 | LYS 355(PLP binding) | |||
| 1c4kA03 |
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| 1ordA03 |
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| 1ordB03 |
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| 1c4kA04 |
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| 1ordA04 |
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| 1ordB04 |
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| References for Catalytic Mechanism | ||
|---|---|---|
| References | Sections | No. of steps in catalysis |
|
[3]
|
p.648-649, Table 1 | |
|
[4]
|
p.851 | |
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[6]
|
Scheme 1 | |
|
[7]
|
p.1983-1984 | |
| References | |
|---|---|
| [1] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 2925664 |
| Journal | J Biol Chem |
| Year | 1989 |
| Volume | 264 |
| Pages | 4722-4 |
| Authors | Momany C, Hackert ML |
| Title | Crystallization and molecular symmetry of ornithine decarboxylase from Lactobacillus 30a. |
| Related PDB | |
| Related UniProtKB | |
| [2] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1715911 |
| Journal | J Electron Microsc Tech |
| Year | 1991 |
| Volume | 18 |
| Pages | 157-66 |
| Authors | Stoops JK, Momany C, Ernst SR, Oliver RM, Schroeter JP, Bretaudiere JP, Hackert ML |
| Title | Comparisons of the low-resolution structures of ornithine decarboxylase by electron microscopy and X-ray crystallography: the utility of methylamine tungstate stain and Butvar support film in the study of macromolecules by transmission electron microscopy. |
| Related PDB | |
| Related UniProtKB | |
| [3] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS). |
| Medline ID | 96017733 |
| PubMed ID | 7563080 |
| Journal | J Mol Biol |
| Year | 1995 |
| Volume | 252 |
| Pages | 643-55 |
| Authors | Momany C, Ernst S, Ghosh R, Chang NL, Hackert ML |
| Title | Crystallographic structure of a PLP-dependent ornithine decarboxylase from Lactobacillus 30a to 3.0 A resolution. |
| Related PDB | 1c4k |
| Related UniProtKB | P43099 |
| [4] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 7663340 |
| Journal | Protein Sci |
| Year | 1995 |
| Volume | 4 |
| Pages | 849-54 |
| Authors | Momany C, Ghosh R, Hackert ML |
| Title | Structural motifs for pyridoxal-5'-phosphate binding in decarboxylases: an analysis based on the crystal structure of the Lactobacillus 30a ornithine decarboxylase. |
| Related PDB | |
| Related UniProtKB | |
| [5] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9405048 |
| Journal | Biochemistry |
| Year | 1997 |
| Volume | 36 |
| Pages | 16147-54 |
| Authors | Oliveira MA, Carroll D, Davidson L, Momany C, Hackert ML |
| Title | The GTP effector site of ornithine decarboxylase from Lactobacillus 30a: kinetic and structural characterization. |
| Related PDB | |
| Related UniProtKB | |
| [6] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 9442028 |
| Journal | J Biol Chem |
| Year | 1998 |
| Volume | 273 |
| Pages | 1939-45 |
| Authors | Tramonti A, De Biase D, Giartosio A, Bossa F, John RA |
| Title | The roles of His-167 and His-275 in the reaction catalyzed by glutamate decarboxylase from Escherichia coli. |
| Related PDB | |
| Related UniProtKB | |
| [7] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS). |
| Medline ID | 20133100 |
| PubMed ID | 10666573 |
| Journal | Acta Crystallogr D Biol Crystallogr |
| Year | 1999 |
| Volume | 55 |
| Pages | 1978-85 |
| Authors | Vitali J, Carroll D, Chaudhry RG, Hackert ML |
| Title | Three-dimensional structure of the Gly121Tyr dimeric form of ornithine decarboxylase from Lactobacillus 30a. |
| Related PDB | 1ord |
| Related UniProtKB | P43099 |
| [8] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10477260 |
| Journal | Biochem J |
| Year | 1999 |
| Volume | 342 Pt 3 |
| Pages | 509-12 |
| Authors | Bertoldi M, Carbone V, Borri Voltattorni C |
| Title | Ornithine and glutamate decarboxylases catalyse an oxidative deamination of their alpha-methyl substrates. |
| Related PDB | |
| Related UniProtKB | |
| Comments |
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| Created | Updated |
|---|---|
| 2004-05-20 | 2009-02-26 |