DB code: M00017
| CATH domain | 3.40.120.10 : Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 3 | Catalytic domain |
|---|---|---|
| 3.40.120.10 : Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 3 | Catalytic domain | |
| 3.40.120.10 : Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 3 | Catalytic domain | |
| 3.30.310.50 : TATA-Binding Protein | ||
| E.C. | 5.4.2.2 | |
| CSA | ||
| M-CSA | ||
| MACiE | ||
| CATH domain | Related DB codes (homologues) |
|---|
| Uniprot Enzyme Name | UniprotKB | Protein name | Synonyms | RefSeq | Pfam |
|---|---|---|---|---|
| P00949 |
Phosphoglucomutase-1
|
PGM 1
EC 5.4.2.2 Glucose phosphomutase 1 |
NP_001075785.1
(Protein)
NM_001082316.1 (DNA/RNA sequence) |
PF02878
(PGM_PMM_I)
PF02879 (PGM_PMM_II) PF02880 (PGM_PMM_III) PF00408 (PGM_PMM_IV) [Graphical View] |
| P47244 |
Phosphoglucomutase-1
|
PGM 1
EC 5.4.2.2 Glucose phosphomutase 1 Parafusin Pf pp63 |
XP_001429571.1
(Protein)
XM_001429534.1 (DNA/RNA sequence) |
PF02878
(PGM_PMM_I)
PF02879 (PGM_PMM_II) PF02880 (PGM_PMM_III) PF00408 (PGM_PMM_IV) [Graphical View] |
| KEGG enzyme name |
|---|
|
phosphoglucomutase
glucose phosphomutase phosphoglucose mutase |
| UniprotKB: Accession Number | Entry name | Activity | Subunit | Subcellular location | Cofactor |
|---|---|---|---|---|---|
| P00949 | PGM1_RABIT | Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate. | Monomer. | Isoform 1: Cytoplasm. Isoform 2: Sarcoplasmic reticulum. Note=Localizes to the junctional skeletal sarcoplasmic reticulum, probably by association with phospholipids and/or other proteins. | Binds 1 magnesium ion per subunit. |
| P47244 | PGM1_PARTE | Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate. | Cytoplasm. | Binds 1 magnesium ion per subunit. |
| KEGG Pathways | Map code | Pathways | E.C. |
|---|---|---|
| MAP00010 | Glycolysis / Gluconeogenesis | |
| MAP00030 | Pentose phosphate pathway | |
| MAP00052 | Galactose metabolism | |
| MAP00500 | Starch and sucrose metabolism | |
| MAP00521 | Streptomycin biosynthesis |
| Compound table | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cofactors | Substrates | Products | Intermediates | |||||||||||
| KEGG-id | C00305 | C00103 | C00620 | C01171 | C00668 | C03736 | C03735 | C00660 | ||||||
| E.C. | ||||||||||||||
| Compound | Magnesium | alpha-D-Glucose 1-phosphate | alpha-D-Ribose 1-phosphate | alpha-D-Hexose 1-phosphate | alpha-D-Glucose 6-phosphate | alpha-D-Ribose 5-phosphate | alpha-D-Hexose 6-phosphate | D-Glucose 1,6-bisphosphate | Transition from Ser to 6-OH | |||||
| Type | divalent metal (Ca2+, Mg2+) | carbohydrate,phosphate group/phosphate ion | carbohydrate,phosphate group/phosphate ion | carbohydrate,phosphate group/phosphate ion | carbohydrate,phosphate group/phosphate ion | carbohydrate,phosphate group/phosphate ion | carbohydrate,phosphate group/phosphate ion | |||||||
| ChEBI |
18420 18420 |
29042 29042 |
16300 16300 |
16326 16326 |
17665 17665 |
18189 18189 |
||||||||
| PubChem |
888 888 |
65533 65533 |
439236 439236 |
439426 439426 |
439284 439284 |
440101 440101 |
440100 440100 |
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| 1c47A01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1c47B01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1c4gA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1c4gB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1jdyA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1jdyB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1lxtA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1lxtB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1vklA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1vklB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 2pmgA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 2pmgB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 3pmgA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 3pmgB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1kfiA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1kfiB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1kfqA01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1kfqB01 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1c47A02 |
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Analogue:_CD | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1c47B02 |
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Analogue:_CD | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1c4gA02 |
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Analogue:_CO | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1c4gB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1jdyA02 |
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Analogue:_CD | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1jdyB02 |
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Analogue:_CD | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1lxtA02 |
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Analogue:_CD | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1lxtB02 |
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Analogue:_CD | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1vklA02 |
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Analogue:_NI | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1vklB02 |
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Analogue:_NI | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 2pmgA02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 2pmgB02 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 3pmgA02 |
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Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 3pmgB02 |
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Bound:_MG | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1kfiA02 |
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Analogue:_ZN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1kfiB02 |
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Analogue:_ZN | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1kfqA02 |
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Analogue:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1kfqB02 |
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Analogue:_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1c47A03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-bound:G16 | Unbound |
| 1c47B03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1c4gA03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:VG1 |
| 1c4gB03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1jdyA03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1jdyB03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1lxtA03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1lxtB03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1vklA03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1vklB03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 2pmgA03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 2pmgB03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 3pmgA03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 3pmgB03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1kfiA03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1kfiB03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1kfqA03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1kfqB03 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1c47A04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1c47B04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1c4gA04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1c4gB04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1jdyA04 |
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Unbound | Analogue:SO4 | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1jdyB04 |
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Unbound | Analogue:SO4 | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1lxtA04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1lxtB04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1vklA04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1vklB04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 2pmgA04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 2pmgB04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 3pmgA04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 3pmgB04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1kfiA04 |
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Unbound | Analogue:SO4 | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1kfiB04 |
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Unbound | Analogue:SO4 | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1kfqA04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| 1kfqB04 |
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Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
| Reference for Active-site residues | ||
|---|---|---|
| resource | references | E.C. |
| literature [14], [16], [17] | ||
| Active-site residues | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Catalytic residues | Cofactor-binding residues | Modified residues | Main-chain involved in catalysis | Comment | |||||
| 1c47A01 |
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ARG 22;SER 116;HIS 117;LYS 129 | SER 116(Magnesium binding) | |||
| 1c47B01 |
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ARG 22;SER 116;HIS 117;LYS 129 | SER 116(Magnesium binding) | |||
| 1c4gA01 |
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ARG 22;SER 116;HIS 117;LYS 129 | SER 116(Magnesium binding) | |||
| 1c4gB01 |
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ARG 22;SER 116;HIS 117;LYS 129 | SER 116(Magnesium binding) | |||
| 1jdyA01 |
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ARG 22; ;HIS 117;LYS 129 | SEP 116(Magnesium binding) | SEP 116(Phosphonoserine) | ||
| 1jdyB01 |
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ARG 22; ;HIS 117;LYS 129 | SEP 116(Magnesium binding) | SEP 116(Phosphonoserine) | ||
| 1lxtA01 |
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ARG 22;SER 116;HIS 117;LYS 129 | SER 116(Magnesium binding) | |||
| 1lxtB01 |
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ARG 22;SER 116;HIS 117;LYS 129 | SER 116(Magnesium binding) | |||
| 1vklA01 |
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ARG 22; ;HIS 117;LYS 129 | SER 116(Magnesium binding) | SEP 116(Phosphonoserine) | ||
| 1vklB01 |
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ARG 22; ;HIS 117;LYS 129 | SER 116(Magnesium binding) | SEP 116(Phosphonoserine) | ||
| 2pmgA01 |
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ARG 22;SER 116;HIS 117;LYS 129 | SER 116(Magnesium binding) | |||
| 2pmgB01 |
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ARG 22;SER 116;HIS 117;LYS 129 | SER 116(Magnesium binding) | |||
| 3pmgA01 |
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ARG 22;SER 116;HIS 117;LYS 129 | SER 116(Magnesium binding) | SEP 116(Phosphorylation) | ||
| 3pmgB01 |
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ARG 22;SER 116;HIS 117;LYS 129 | SER 116(Magnesium binding) | SEP 116(Phosphorylation) | ||
| 1kfiA01 |
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ARG 27;SER 126;HIS 127;LYS 140 | SER 126(Magnesium binding) | SER 126(Phosphorylation) | ||
| 1kfiB01 |
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ARG 27;SER 126;HIS 127;LYS 140 | SER 126(Magnesium binding) | SER 126(Phosphorylation) | ||
| 1kfqA01 |
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ARG 27;SER 126;HIS 127;LYS 140 | SER 126(Magnesium binding) | SER 126(Phosphorylation) | ||
| 1kfqB01 |
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ARG 27;SER 126;HIS 127;LYS 140 | SER 126(Magnesium binding) | SER 126(Phosphorylation) | ||
| 1c47A02 |
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ARG 292 | ASP 287;ASP 289;ASP 291(Magnesium binding) | |||
| 1c47B02 |
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ARG 292 | ASP 287;ASP 289;ASP 291(Magnesium binding) | |||
| 1c4gA02 |
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ARG 292 | ASP 287;ASP 289;ASP 291(Magnesium binding) | |||
| 1c4gB02 |
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ARG 292 | ASP 287;ASP 289;ASP 291(Magnesium binding) | |||
| 1jdyA02 |
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ARG 292 | ASP 287;ASP 289;ASP 291(Magnesium binding) | |||
| 1jdyB02 |
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ARG 292 | ASP 287;ASP 289;ASP 291(Magnesium binding) | |||
| 1lxtA02 |
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ARG 292 | ASP 287;ASP 289;ASP 291(Magnesium binding) | |||
| 1lxtB02 |
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ARG 292 | ASP 287;ASP 289;ASP 291(Magnesium binding) | |||
| 1vklA02 |
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ARG 292 | ASP 287;ASP 289;ASP 291(Magnesium binding) | |||
| 1vklB02 |
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ARG 292 | ASP 287;ASP 289;ASP 291(Magnesium binding) | |||
| 2pmgA02 |
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ARG 292 | ASP 287;ASP 289;ASP 291(Magnesium binding) | |||
| 2pmgB02 |
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ARG 292 | ASP 287;ASP 289;ASP 291(Magnesium binding) | |||
| 3pmgA02 |
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ARG 292 | ASP 287;ASP 289;ASP 291(Magnesium binding) | |||
| 3pmgB02 |
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ARG 292 | ASP 287;ASP 289;ASP 291(Magnesium binding) | |||
| 1kfiA02 |
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ARG 313 | ASP 308;ASP 310;ASP 312(Magnesium binding) | |||
| 1kfiB02 |
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ARG 313 | ASP 308;ASP 310;ASP 312(Magnesium binding) | |||
| 1kfqA02 |
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ARG 313 | ASP 308;ASP 310;ASP 312(Magnesium binding) | |||
| 1kfqB02 |
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ARG 313 | ASP 308;ASP 310;ASP 312(Magnesium binding) | |||
| 1c47A03 |
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LYS 388 | ||||
| 1c47B03 |
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LYS 388 | ||||
| 1c4gA03 |
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LYS 388 | ||||
| 1c4gB03 |
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LYS 388 | ||||
| 1jdyA03 |
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LYS 388 | ||||
| 1jdyB03 |
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LYS 388 | ||||
| 1lxtA03 |
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LYS 388 | ||||
| 1lxtB03 |
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LYS 388 | ||||
| 1vklA03 |
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LYS 388 | ||||
| 1vklB03 |
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LYS 388 | ||||
| 2pmgA03 |
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LYS 388 | ||||
| 2pmgB03 |
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LYS 388 | ||||
| 3pmgA03 |
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LYS 388 | ||||
| 3pmgB03 |
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LYS 388 | ||||
| 1kfiA03 |
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LYS 405 | ||||
| 1kfiB03 |
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LYS 405 | ||||
| 1kfqA03 |
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LYS 405 | ||||
| 1kfqB03 |
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LYS 405 | ||||
| 1c47A04 |
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| 1c47B04 |
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| 1c4gA04 |
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| 1c4gB04 |
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| 1jdyA04 |
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| 1jdyB04 |
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| 1lxtA04 |
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| 1lxtB04 |
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| 1vklA04 |
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| 1vklB04 |
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| 2pmgA04 |
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| 2pmgB04 |
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| 3pmgA04 |
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| 3pmgB04 |
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| 1kfiA04 |
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| 1kfiB04 |
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| 1kfqA04 |
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| 1kfqB04 |
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| References for Catalytic Mechanism | ||
|---|---|---|
| References | Sections | No. of steps in catalysis |
|
[9]
|
Scheme II, p.504 | |
|
[10]
|
p.511-512 | |
|
[11]
|
p.6328-6329 | |
|
[12]
|
p.52-55 | |
|
[14]
|
p.404-405 | |
|
[16]
|
p.148 | |
|
[17]
|
Fig.5, p.275-277 | |
|
[18]
|
Chart 1, p.9948-9950 | |
|
[19]
|
Fig.1, p.60-61 | |
| References | |
|---|---|
| [1] | |
| Resource | |
| Comments | ACTIVE SITE |
| Medline ID | 68368401 |
| PubMed ID | 5669853 |
| Journal | Biochem J |
| Year | 1968 |
| Volume | 109 |
| Pages | 93-9 |
| Authors | Milstein CP, Milstein C |
| Title | A tryptic peptide containing a unique serine phosphate residue in rabbit phosphoglucomutase. |
| Related PDB | |
| Related UniProtKB | P00949 |
| [2] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 5041899 |
| Journal | Biochemistry |
| Year | 1972 |
| Volume | 11 |
| Pages | 2800-4 |
| Authors | Ray WJ Jr, Goodin DS, Ng L |
| Title | Cobalt (II) and nickel (II) complexes of phosphoglucomutase. |
| Related PDB | |
| Related UniProtKB | |
| [3] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 4830239 |
| Journal | J Biol Chem |
| Year | 1974 |
| Volume | 249 |
| Pages | 3166-9 |
| Authors | Walinder O, Joshi JG |
| Title |
Mechanism of action of rabbit muscle phosphoglucomutase. |
| Related PDB | |
| Related UniProtKB | |
| [4] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 6115419 |
| Journal | Philos Trans R Soc Lond B Biol Sci |
| Year | 1981 |
| Volume | 293 |
| Pages | 205-8 |
| Authors | Wierenga RK, Lewis DG, Rossmann MG, Ray WJ Jr |
| Title | The structure determination of rabbit phosphoglucomutase. |
| Related PDB | |
| Related UniProtKB | |
| [5] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 2934384 |
| Journal | J Biol Chem |
| Year | 1986 |
| Volume | 261 |
| Pages | 264-74 |
| Authors | Lin Z, Konno M, Abad-Zapatero C, Wierenga R, Murthy MR, Ray WJ Jr, Rossmann MG |
| Title | The structure of rabbit muscle phosphoglucomutase at intermediate resolution. |
| Related PDB | |
| Related UniProtKB | |
| [6] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 2974722 |
| Journal | Biochemistry |
| Year | 1988 |
| Volume | 27 |
| Pages | 7328-32 |
| Authors | Kim SC, Raushel FM |
| Title | Mechanism-based inactivation of rabbit muscle phosphoglucomutase by nojirimycin 6-phosphate. |
| Related PDB | |
| Related UniProtKB | |
| [7] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1712631 |
| Journal | Biochemistry |
| Year | 1991 |
| Volume | 30 |
| Pages | 6866-75 |
| Authors | Ray WJ Jr, Bolin JT, Puvathingal JM, Minor W, Liu YW, Muchmore SW |
| Title |
Removal of salt from a salt-induced protein crystal without cross-linking. |
| Related PDB | |
| Related UniProtKB | |
| [8] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1829964 |
| Journal | Biochemistry |
| Year | 1991 |
| Volume | 30 |
| Pages | 6875-85 |
| Authors | Ray WJ Jr, Puvathingal JM, Liu YW |
| Title | Formation of substrate and transition-state analogue complexes in crystals of phosphoglucomutase after removing the crystallization salt. |
| Related PDB | |
| Related UniProtKB | |
| [9] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1531025 |
| Journal | Biochemistry |
| Year | 1992 |
| Volume | 31 |
| Pages | 498-505 |
| Authors | Percival MD, Withers SG |
| Title | Binding energy and catalysis: deoxyfluoro sugars as probes of hydrogen bonding in phosphoglucomutase. |
| Related PDB | |
| Related UniProtKB | |
| [10] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 1531026 |
| Journal | Biochemistry |
| Year | 1992 |
| Volume | 31 |
| Pages | 505-12 |
| Authors | Percival MD, Withers SG |
| Title | 19F NMR investigations of the catalytic mechanism of phosphoglucomutase using fluorinated substrates and inhibitors. |
| Related PDB | |
| Related UniProtKB | |
| [11] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) |
| Medline ID | 92210613 |
| PubMed ID | 1532581 |
| Journal | J Biol Chem |
| Year | 1992 |
| Volume | 267 |
| Pages | 6322-37 |
| Authors | Dai JB, Liu Y, Ray WJ Jr, Konno M |
| Title | The crystal structure of muscle phosphoglucomutase refined at 2.7-angstrom resolution. |
| Related PDB | 2pmg |
| Related UniProtKB | P00949 |
| [12] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8418859 |
| Journal | Biochemistry |
| Year | 1993 |
| Volume | 32 |
| Pages | 48-57 |
| Authors | Ray WJ Jr, Post CB, Liu Y, Rhyu GI |
| Title | Structural changes at the metal ion binding site during the phosphoglucomutase reaction. |
| Related PDB | |
| Related UniProtKB | |
| [13] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 8418857 |
| Journal | Biochemistry |
| Year | 1993 |
| Volume | 32 |
| Pages | 38-47 |
| Authors | Ray WJ Jr, Post CB, Puvathingal JM |
| Title |
Reaction of the isosteric methylenephosphonate analog of alpha-D-glucose 1-phosphate with phosphoglucomutase. |
| Related PDB | |
| Related UniProtKB | |
| [14] | |
| Resource | |
| Comments | X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) |
| Medline ID | |
| PubMed ID | 15299905 |
| Journal | Acta Crystallogr D Biol Crystallogr |
| Year | 1997 |
| Volume | 53 |
| Pages | 392-405 |
| Authors | Liu Y, Ray WJ Jr, Baranidharan S |
| Title | Structure of rabbit muscle phosphoglucomutase refined at 2.4-A |
| Related PDB | 1lxt |
| Related UniProtKB | P00949 |
| [15] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 10506283 |
| Journal | Protein Eng |
| Year | 1999 |
| Volume | 12 |
| Pages | 737-46 |
| Authors | Levin S, Almo SC, Satir BH |
| Title | Functional diversity of the phosphoglucomutase superfamily: structural implications. |
| Related PDB | |
| Related UniProtKB | |
| [16] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11779235 |
| Journal | J Mol Biol |
| Year | 2002 |
| Volume | 315 |
| Pages | 141-53 |
| Authors | Muller S, Diederichs K, Breed J, Kissmehl R, Hauser K, Plattner H, Welte W |
| Title |
Crystal structure analysis of the exocytosis-sensitive phosphoprotein, |
| Related PDB | 1kfi 1kfq |
| Related UniProtKB | P47244 |
| [17] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 11839312 |
| Journal | Structure (Camb) |
| Year | 2002 |
| Volume | 10 |
| Pages | 269-79 |
| Authors | Regni C, Tipton PA, Beamer LJ |
| Title |
Crystal structure of PMM/PGM: an enzyme in the biosynthetic pathway of P. |
| Related PDB | |
| Related UniProtKB | |
| [18] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 12924943 |
| Journal | Biochemistry |
| Year | 2003 |
| Volume | 42 |
| Pages | 9946-51 |
| Authors | Naught LE, Regni C, Beamer LJ, Tipton PA |
| Title | Roles of active site residues in Pseudomonas aeruginosa phosphomannomutase/phosphoglucomutase. |
| Related PDB | |
| Related UniProtKB | |
| [19] | |
| Resource | |
| Comments | |
| Medline ID | |
| PubMed ID | 14725765 |
| Journal | Structure (Camb) |
| Year | 2004 |
| Volume | 12 |
| Pages | 55-63 |
| Authors | Regni C, Naught L, Tipton PA, Beamer LJ |
| Title |
Structural basis of diverse substrate recognition by the enzyme PMM/PGM from P. |
| Related PDB | |
| Related UniProtKB | |
| Comments |
|---|
|
This enzyme catalyzes two phosphoryl transfer reactions as follows:
(A) Transfer of phosphoryl group from hydroxyl group of Ser116 to 6-OH of glucose-1-phosphate, (B) Transfer of phosphoryl group from 1-OH of a glucose-1,6-diphosphate intermediate to Ser: |
| Created | Updated |
|---|---|
| 2005-06-10 | 2009-02-26 |