RLCP 6.40.-.- :EzCatDB EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms


R 6.-.-.- : Exchange of double-bonded atoms (Schiff-base related reaction) (Reaction)

L 6.40.-.- : Exchange of Schiff-base nitrogen atoms (internal aldimine formation) (Ligand group involved)

Catalytic mechanisms

  • 6.40.477300.- : Nucleophile/Base-Acid-Base; Base-activated nucleophile attacks on double-bond partner atom; Acid protonation to leaving group; Formation of tetrahedral intermediate; 2nd base deprotonation of nucleophile; Lone pair on nucleophile attacks again on double-bond partner atom; Organic-cofactor-assisted reaction

  • 6.40.500000.- : Nucleophile/Acid/Modulator; Nucleophile attacks on double-bond partner atom; Formation of tetrahedral intermediate; protonation to leaving group; Organic-cofactor-assisted activation of nucleophile; Lone pair on nucleophile attacks on double-bond partner atom

  • 6.40.508000.- : Nucleophile/Acid/Modulator; Nucleophile attacks on double-bond partner atom; Formation of tetrahedral intermediate; Organic-cofactor-assisted protonation to leaving group & deprotonation of nucleophile; Lone pair on nucleophile attacks on double-bond partner atom

  • 6.40.521000.- : Nucleophile/Acid/Modulator; Nucleophile attacks on double-bond partner atom; Acid protonation to leaving group; Formation of tetrahedral intermediate; Lone pair on nucleophile attacks on double-bond partner atom; Organic-cofactor/Modulator-assisted proton transfer from nucleophile to leaving group

  • 6.40.521010.- : Nucleophile-Acid/Modulator; Nucleophile attacks on double-bond partner atom; Acid protonation to leaving group through water; Formation of tetrahedral intermediate; Lone pair on nucleophile attacks on double-bond partner atom; Organic-cofactor/Modulator-assisted proton transfer from nucleophile to leaving group through water

  • 6.40.528600.- : Nucleophile/Modulator; Modulator-assisted nucleophile attacks on double-bond partner atom; Formation of tetrahedral intermediate; Organic-cofactor-assisted proton transfer between nucleophile and leaving group; Lone pair on nucleophile attacks on double-bond partner atom; substrate-assisted protonation to leaving group

    • Copyright: Nozomi Nagano, JST & CBRC-AIST
    Funded by PRESTO/Japan Science and Technology Agency (JST) (December 2001 - November 2004)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
    Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (September 2005 - September 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (October 2007 - September 2010)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2012 - March 2013)
    Supported by the commission for the Development of Artificial Gene Synthesis Technology for Creating Innovative Biomaterial from the Ministry of Economy, Trade and Industry (METI) (October 2012 - March 2016)
    Funded by the project commissioned by the New Energy and Industrial Technology Development Organization (NEDO) (April 2016 -)