RLCP 4.1034.769660.- :EzCatDB EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms


R 4.-.-.- : Addition to double-bond (new bond formation and decreased bond-order) (Reaction)

L 4.1034.-.- : Carboxylate oxygen to Carbon (sp2) adjacent to double-bond; Opposition to non-beta-elimination (Ligand group involved)

C 4.1034.769660.- : Metal-dependent bacterial MLE-like mechanism(Acid-Base/Acid/Stabilizer); Nucleophilic attack on added site & Acid protonation; Cofactor-assisted stabilization of intermediate/product (Catalytic mechanism)

1st Nucleophile : Added group (substrate or water)
Catalytic groups : cofactor + groups in residue/substrate
General Base : non-existent
General Acid : a catalytic residue

Residues/Cofactors involved in Proteins

  • 4.1034.769660.650 : An acidic residue + Lys + manganese ion bound to acidic residues

    • Copyright: Nozomi Nagano, JST & CBRC-AIST
    Funded by PRESTO/Japan Science and Technology Agency (JST) (December 2001 - November 2004)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
    Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (September 2005 - September 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (October 2007 - September 2010)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2012 - March 2013)
    Supported by the commission for the Development of Artificial Gene Synthesis Technology for Creating Innovative Biomaterial from the Ministry of Economy, Trade and Industry (METI) (October 2012 - March 2016)
    Funded by the project commissioned by the New Energy and Industrial Technology Development Organization (NEDO) (April 2016 -)