R L C P
Hierarchic Classification of Catalytic Mechanisms

R 1.-.-.- : Hydrolysis (bond cleavage by water) (Reaction)

L 1.40.-.- : C-N bond (N-glycoside bond) (Ligand group involved)

Catalytic mechanisms

1.40.300.- : Exoglucanase-II-like mechanism (Acid/Base); Base-activated water directly attacks on substrate & hydrolysis assisted by proton donor (SN2)

1.40.4930.- : Uracil-DNA glycosylase-like mechanism (Base-Stabilizer/Acid-Stabilizer); Substrate-assisted stabilization of SN1-like transition state; Base activation of water; nucleophilic attack by water molecule; Acid protonation to leaving group

1.40.6430.- : AlkA-DNA-glycosylase-like mechanism (Stabilizer); To-be-hydrolyzed group leads to transition-state; Stabilization of transition-state leads to SN1-like bond cleavage; Leaving group acts as a (substrate-assisted) base to activate water; Water attacks on the transition-state

1.40.7050.- : TAG-DNA-glycosylase-like mechanism (Stabilizer); Stabilization of leaving group leads to transition-state; Water attacks on the transition-state; SN1-like reaction

1.40.14550.- : IU-nucleoside hydrolase-like mechanism (Acid/Base); Cofactor-assisted water activation by base; Protonation to leaving group by acid; Nucleophilic attack of water on the bond leads to SN1-like reaction