RLCP 1.20.-.- :EzCatDB EzCatDB

R L C P
Hierarchic Classification of Catalytic Mechanisms


R 1.-.-.- : Hydrolysis (bond cleavage by water) (Reaction)

L 1.20.-.- : Halide bond (Ligand group involved)

Catalytic mechanisms

  • 1.20.30800.- : L-2-haloacid dehalogenase-like mechanism (Nucleophile/Base/Stabilizers/Modulator); SN2-like reaction; Nucleophilic attack on target bond & stabilization of leaving group; intermediate stablilized; Modulator-assisted base activation of water; Intermediate attacked by activated water

  • 1.20.30810.- : Halogenase-like mechanism (Nucleophile/Base/Modulator/Stabilizers); Nucleophilic attack on target bond; Stabilizer for leaving group assists SN2-like reaction; covalent bond between enzyme and substrate (intermediate formation); hydrolysis by base-activated water; intermediate-2; intermediate-2 deformation & hydroxyl group from water protonates to leaving atom

    • Copyright: Nozomi Nagano, JST & CBRC-AIST
    Funded by PRESTO/Japan Science and Technology Agency (JST) (December 2001 - November 2004)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
    Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (September 2005 - September 2008)
    Funded by BIRD/Japan Science and Technology Agency (JST) (October 2007 - September 2010)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)
    Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2012 - March 2013)
    Supported by the commission for the Development of Artificial Gene Synthesis Technology for Creating Innovative Biomaterial from the Ministry of Economy, Trade and Industry (METI) (October 2012 - March 2016)
    Funded by the project commissioned by the New Energy and Industrial Technology Development Organization (NEDO) (April 2016 -)