M00180
type: Enzyme
active site residues resources: Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis.
active site residues resources: P04035
cath: http://ezcatdb.cbrc.jp/EzCatDB/cath/-.-.-.-
cath: HMGR, N-terminal domain
cath: 3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2
cath: Alpha-Beta Plaits
csa: 1dqa
ec: https://purl.uniprot.org/enzyme/1.1.1.34
kegg enzyme: hydroxymethylglutaryl-CoA reductase (NADPH)
kegg intermediate: Mevaldyl-CoA
kegg intermediate: Mevaldehyde
kegg pathway: Biosynthesis of steroids
kegg product: (R)-Mevalonate
kegg product: CoA
kegg product: NADP+
kegg substrate: (S)-3-Hydroxy-3-methylglutaryl-CoA
kegg substrate: NADPH
kegg substrate: H+
macie: M0093
pdb: 1dq8A01
pdb: 1dq8B01
pdb: 1dq8C01
pdb: 1dq8D01
pdb: 1dq9A01
pdb: 1dq9B01
pdb: 1dq9C01
pdb: 1dq9D01
pdb: 1dqaA01
pdb: 1dqaB01
pdb: 1dqaC01
pdb: 1dqaD01
pdb: 1hw8A01
pdb: 1hw8B01
pdb: 1hw8C01
pdb: 1hw8D01
pdb: 1hw9A01
pdb: 1hw9B01
pdb: 1hw9C01
pdb: 1hw9D01
pdb: 1hwiA01
pdb: 1hwiB01
pdb: 1hwiC01
pdb: 1hwiD01
pdb: 1hwjA01
pdb: 1hwjB01
pdb: 1hwjC01
pdb: 1hwjD01
pdb: 1hwkA01
pdb: 1hwkB01
pdb: 1hwkC01
pdb: 1hwkD01
pdb: 1hwlA01
pdb: 1hwlB01
pdb: 1hwlC01
pdb: 1hwlD01
pdb: 1dq8A02
pdb: 1dq8B02
pdb: 1dq8C02
pdb: 1dq8D02
pdb: 1dq9A02
pdb: 1dq9B02
pdb: 1dq9C02
pdb: 1dq9D02
pdb: 1dqaA02
pdb: 1dqaB02
pdb: 1dqaC02
pdb: 1dqaD02
pdb: 1hw8A02
pdb: 1hw8B02
pdb: 1hw8C02
pdb: 1hw8D02
pdb: 1hw9A02
pdb: 1hw9B02
pdb: 1hw9C02
pdb: 1hw9D02
pdb: 1hwiA02
pdb: 1hwiB02
pdb: 1hwiC02
pdb: 1hwiD02

Analogue
compound: CoA
ligand het code: ADP
pdb: 1hw8B02

Analogue
compound: CoA
ligand het code: ADP
pdb: 1hw9A02

Analogue
compound: CoA
ligand het code: ADP
pdb: 1hw9B02

Analogue
compound: CoA
ligand het code: ADP
pdb: 1hw9D02

Analogue
compound: CoA
ligand het code: ADP
pdb: 1hwiA02

Analogue
compound: CoA
ligand het code: ADP
pdb: 1hwjA02

Analogue
compound: CoA
ligand het code: ADP
pdb: 1hwjB02

Analogue
compound: CoA
ligand het code: ADP
pdb: 1hwjD02

Analogue
compound: CoA
ligand het code: ADP
pdb: 1hwkA02

Analogue
compound: CoA
ligand het code: ADP
pdb: 1hwkB02

Analogue
compound: CoA
ligand het code: ADP
pdb: 1hwlA02

Analogue
compound: CoA
ligand het code: ADP
pdb: 1hwlB02

Analogue
compound: CoA
ligand het code: ADP
pdb: 1hwlD02

Analogue
compound: NADP+
ligand het code: ADP
pdb: 1hw8D03

Analogue
compound: NADP+
ligand het code: ADP
pdb: 1hw9B03

Analogue
compound: NADP+
ligand het code: ADP
pdb: 1hw9D03

Analogue
compound: NADP+
ligand het code: ADP
pdb: 1hwiB03

Analogue
compound: NADP+
ligand het code: ADP
pdb: 1hwiD03

Analogue
compound: NADP+
ligand het code: ADP
pdb: 1hwjB03

Analogue
compound: NADP+
ligand het code: ADP
pdb: 1hwjC03

Analogue
compound: NADP+
ligand het code: ADP
pdb: 1hwjD03

Analogue
compound: NADP+
ligand het code: ADP
pdb: 1hwkA03

Analogue
compound: NADP+
ligand het code: ADP
pdb: 1hwkB03

Analogue
compound: NADP+
ligand het code: ADP
pdb: 1hwkD03

IntermediateAnalogue
compound: Mevaldyl-CoA
ligand het code: 114
pdb: 1hw8A02

IntermediateAnalogue
compound: Mevaldyl-CoA
ligand het code: 114
pdb: 1hw8B02

IntermediateAnalogue
compound: Mevaldyl-CoA
ligand het code: 114
pdb: 1hw8C02

IntermediateAnalogue
compound: Mevaldyl-CoA
ligand het code: 114
pdb: 1hw8D02

IntermediateAnalogue
compound: Mevaldyl-CoA
ligand het code: SIM
pdb: 1hw9A02

IntermediateAnalogue
compound: Mevaldyl-CoA
ligand het code: SIM
pdb: 1hw9B02

IntermediateAnalogue
compound: Mevaldyl-CoA
ligand het code: SIM
pdb: 1hw9C02

IntermediateAnalogue
compound: Mevaldyl-CoA
ligand het code: SIM
pdb: 1hw9D02

IntermediateAnalogue
compound: Mevaldyl-CoA
ligand het code: 115
pdb: 1hwiA02

IntermediateAnalogue
compound: Mevaldyl-CoA
ligand het code: 115
pdb: 1hwiB02

IntermediateAnalogue
compound: Mevaldyl-CoA
ligand het code: 115
pdb: 1hwiC02

IntermediateAnalogue
compound: Mevaldyl-CoA
ligand het code: 115
pdb: 1hwiD02

IntermediateAnalogue
compound: Mevaldyl-CoA
ligand het code: 116
pdb: 1hwjA02

IntermediateAnalogue
compound: Mevaldyl-CoA
ligand het code: 116
pdb: 1hwjB02

IntermediateAnalogue
compound: Mevaldyl-CoA
ligand het code: 116
pdb: 1hwjC02

IntermediateAnalogue
compound: Mevaldyl-CoA
ligand het code: 116
pdb: 1hwjD02

IntermediateAnalogue
compound: Mevaldyl-CoA
ligand het code: 117
pdb: 1hwkA02

IntermediateAnalogue
compound: Mevaldyl-CoA
ligand het code: 117
pdb: 1hwkB02

IntermediateAnalogue
compound: Mevaldyl-CoA
ligand het code: 117
pdb: 1hwkC02

IntermediateAnalogue
compound: Mevaldyl-CoA
ligand het code: 117
pdb: 1hwkD02

IntermediateAnalogue
compound: Mevaldyl-CoA
ligand het code: FBI
pdb: 1hwlA02

IntermediateAnalogue
compound: Mevaldyl-CoA
ligand het code: FBI
pdb: 1hwlB02

IntermediateAnalogue
compound: Mevaldyl-CoA
ligand het code: FBI
pdb: 1hwlC02

IntermediateAnalogue
compound: Mevaldyl-CoA
ligand het code: FBI
pdb: 1hwlD02

IntermediateAnalogue
compound: Mevaldehyde
ligand het code: MAH
pdb: 1dq8A02

IntermediateAnalogue
compound: Mevaldehyde
ligand het code: MAH
pdb: 1dq8B02

IntermediateAnalogue
compound: Mevaldehyde
ligand het code: MAH
pdb: 1dq8C02

IntermediateAnalogue
compound: Mevaldehyde
ligand het code: MAH
pdb: 1dq8D02

IntermediateAnalogue
compound: Mevaldehyde
ligand het code: MAH
pdb: 1dqaA02

IntermediateAnalogue
compound: Mevaldehyde
ligand het code: MAH
pdb: 1dqaB02

IntermediateAnalogue
compound: Mevaldehyde
ligand het code: MAH
pdb: 1dqaC02

IntermediateAnalogue
compound: Mevaldehyde
ligand het code: MAH
pdb: 1dqaD02

ReferenceForCatalyticMechanism
reference index: 8
reference section: Fig.1

ReferenceForCatalyticMechanism
reference index: 13
reference section: Fig.7, p.11481-11482

ReferenceForCatalyticMechanism
reference index: 15
reference section: Fig.8, p.16865-16866

ReferenceForCatalyticMechanism
reference index: 17
reference section: Scheme 1, Scheme 2

ReferenceForCatalyticMechanism
reference index: 19
reference section: Fig. 1, Fig. 5, p.14-16

ReferenceForCatalyticMechanism
reference index: 20
reference section: p.826-827

HMGR, N-terminal domain
type: Cath
references: http://www.cathdb.info/version/latest/superfamily/1.10.3270.10

Alpha-Beta Plaits
type: Cath
catalytic domain: index.html
references: http://www.cathdb.info/version/latest/superfamily/3.30.70.420

3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2
type: Cath
catalytic domain: index.html
references: http://www.cathdb.info/version/latest/superfamily/3.90.770.10

H+
type: KeggSubstrate
compound type: others
references: KEGG:C00080
references: CHEBI:15378
references: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi

Biosynthesis of steroids
type: KeggPathway
references: KEGG:MAP00100

Regulation of vertebrate liver HMG-CoA reductase via reversible modulation of its catalytic activity.
type: BibliographicResource
authors:
  item: Hunter CF
  item: Rodwell VW
journal: J Lipid Res
pages: 399-405
published year: 1980
volume: 21
references: http://www.ncbi.nlm.nih.gov/pubmed/6247408

Syrian hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase expressed in Escherichia coli: production of homogeneous protein.
type: BibliographicResource
authors:
  item: Frimpong K
  item: Darnay BG
  item: Rodwell VW
journal: Protein Expr Purif
pages: 337-44
published year: 1993
volume: 4
references: http://www.ncbi.nlm.nih.gov/pubmed/8374303

Biochemical characterization of two forms of 3-hydroxy-3-methylglutaryl-CoA reductase kinase from cauliflower (Brassica oleracia).
type: BibliographicResource
authors:
  item: Ball KL
  item: Dale S
  item: Weekes J
  item: Hardie DG
journal: Eur J Biochem
pages: 743-50
published year: 1994
volume: 219
references: http://www.ncbi.nlm.nih.gov/pubmed/8112324

The active site of hamster 3-hydroxy-3-methylglutaryl-CoA reductase resides at the subunit interface and incorporates catalytically essential acidic residues from separate polypeptides.
type: BibliographicResource
authors:
  item: Frimpong K
  item: Rodwell VW
journal: J Biol Chem
pages: 1217-21
published year: 1994
volume: 269
references: http://www.ncbi.nlm.nih.gov/pubmed/8288583

Catalysis by Syrian hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Proposed roles of histidine 865, glutamate 558, and aspartate 766.
type: BibliographicResource
authors:
  item: Frimpong K
  item: Rodwell VW
journal: J Biol Chem
pages: 11478-83
published year: 1994
volume: 269
references: http://www.ncbi.nlm.nih.gov/pubmed/7908908

Modulation of Syrian hamster 3-hydroxy-3-methylglutaryl-CoA reductase activity by phosphorylation. Role of serine 871.
type: BibliographicResource
authors:
  item: Omkumar RV
  item: Darnay BG
  item: Rodwell VW
journal: J Biol Chem
pages: 6810-4
published year: 1994
volume: 269
references: http://www.ncbi.nlm.nih.gov/pubmed/8120043

Phosphorylation of Ser871 impairs the function of His865 of Syrian hamster 3-hydroxy-3-methylglutaryl-CoA reductase.
type: BibliographicResource
authors:
  item: Omkumar RV
  item: Rodwell VW
journal: J Biol Chem
pages: 16862-6
published year: 1994
volume: 269
references: http://www.ncbi.nlm.nih.gov/pubmed/8207009

Arabidopsis thaliana contains two differentially expressed 3-hydroxy-3-methylglutaryl-CoA reductase genes, which encode microsomal forms of the enzyme.
type: BibliographicResource
authors:
  item: Enjuto M
  item: Balcells L
  item: Campos N
  item: Caelles C
  item: Arro M
  item: Boronat A
journal: Proc Natl Acad Sci U S A
pages: 927-31
published year: 1994
volume: 91
references: http://www.ncbi.nlm.nih.gov/pubmed/8302869

Aminoethylcysteine can replace the function of the essential active site lysine of Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl coenzyme A reductase.
type: BibliographicResource
authors:
  item: Bochar DA
  item: Tabernero L
  item: Stauffacher CV
  item: Rodwell VW
journal: Biochemistry
pages: 8879-83
published year: 1999
volume: 38
references: http://www.ncbi.nlm.nih.gov/pubmed/10413460

Purification, characterization, and cloning of a eubacterial 3-hydroxy-3-methylglutaryl coenzyme A reductase, a key enzyme involved in biosynthesis of terpenoids.
type: BibliographicResource
authors:
  item: Takahashi S
  item: Kuzuyama T
  item: Seto H
journal: J Bacteriol
pages: 1256-63
published year: 1999
volume: 181
references: http://www.ncbi.nlm.nih.gov/pubmed/9973353

The structure of the catalytic portion of human HMG-CoA reductase.
type: BibliographicResource
authors:
  item: Istvan ES
  item: Deisenhofer J
journal: Biochim Biophys Acta
pages: 9-18
published year: 2000
volume: 1529
references: http://www.ncbi.nlm.nih.gov/pubmed/11111074

Human 3-hydroxy-3-methylglutaryl coenzyme A reductase. Conserved domains responsible for catalytic activity and sterol-regulated degradation.
type: BibliographicResource
authors:
  item: Luskey KL
  item: Stevens B
journal: J Biol Chem
pages: 10271-7
published year: 1985
volume: 260
references: http://www.ncbi.nlm.nih.gov/pubmed/2991281

Cloning and characterization of the gene encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase in melon (Cucumis melo L. reticulatus).
type: BibliographicResource
authors:
  item: Kato-Emori S
  item: Higashi K
  item: Hosoya K
  item: Kobayashi T
  item: Ezura H
journal: Mol Genet Genomics
pages: 135-42
published year: 2001
volume: 265
references: http://www.ncbi.nlm.nih.gov/pubmed/11370859

Structural mechanism for statin inhibition of HMG-CoA reductase.
type: BibliographicResource
authors:
  item: Istvan ES
  item: Deisenhofer J
journal: Science
pages: 1160-4
published year: 2001
volume: 292
references: http://www.ncbi.nlm.nih.gov/pubmed/11349148
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
comment: X-ray crystallography

Purification and properties of the catalytic domain of human 3-hydroxy-3-methylglutaryl-CoA reductase expressed in Escherichia coli.
type: BibliographicResource
authors:
  item: Mayer RJ
  item: Debouck C
  item: Metcalf BW
journal: Arch Biochem Biophys
pages: 110-8
published year: 1988
volume: 267
references: http://www.ncbi.nlm.nih.gov/pubmed/3058035

Structural and functional conservation between yeast and human 3-hydroxy-3-methylglutaryl coenzyme A reductases, the rate-limiting enzyme of sterol biosynthesis.
type: BibliographicResource
authors:
  item: Basson ME
  item: Thorsness M
  item: Finer-Moore J
  item: Stroud RM
  item: Rine J
journal: Mol Cell Biol
pages: 3797-808
published year: 1988
volume: 8
references: http://www.ncbi.nlm.nih.gov/pubmed/3065625

Isolation and structural characterization of a cDNA encoding Arabidopsis thaliana 3-hydroxy-3-methylglutaryl coenzyme A reductase.
type: BibliographicResource
authors:
  item: Caelles C
  item: Ferrer A
  item: Balcells L
  item: Hegardt FG
  item: Boronat A
journal: Plant Mol Biol
pages: 627-38
published year: 1989
volume: 13
references: http://www.ncbi.nlm.nih.gov/pubmed/2491679

Molecular cloning and sequence analysis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase from the human parasite Schistosoma mansoni.
type: BibliographicResource
authors:
  item: Rajkovic A
  item: Simonsen JN
  item: Davis RE
  item: Rottman FM
journal: Proc Natl Acad Sci U S A
pages: 8217-21
published year: 1989
volume: 86
references: http://www.ncbi.nlm.nih.gov/pubmed/2813388

Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver.
type: BibliographicResource
authors:
  item: Clarke PR
  item: Hardie DG
journal: EMBO J
pages: 2439-46
published year: 1990
volume: 9
references: http://www.ncbi.nlm.nih.gov/pubmed/2369897

Identification of the principal catalytically important acidic residue of 3-hydroxy-3-methylglutaryl coenzyme A reductase.
type: BibliographicResource
authors:
  item: Wang Y
  item: Darnay BG
  item: Rodwell VW
journal: J Biol Chem
pages: 21634-41
published year: 1990
volume: 265
references: http://www.ncbi.nlm.nih.gov/pubmed/2123872

Aspects related to mevalonate biosynthesis in plants.
type: BibliographicResource
authors:
  item: Bach TJ
  item: Boronat A
  item: Caelles C
  item: Ferrer A
  item: Weber T
  item: Wettstein A
journal: Lipids
pages: 637-48
published year: 1991
volume: 26
references: http://www.ncbi.nlm.nih.gov/pubmed/1685759

Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis.
type: BibliographicResource
authors:
  item: Istvan ES
  item: Palnitkar M
  item: Buchanan SK
  item: Deisenhofer J
journal: EMBO J
pages: 819-30
published year: 2000
volume: 19
references: http://www.ncbi.nlm.nih.gov/pubmed/10698924
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
comment: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 422-888, AND SUBUNIT.

1dq8A02
type: Pdb
catalytic residue: GLU 559;ASP 767;
references: 1dq8
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dq8
comment: invisible H866

1dq8B02
type: Pdb
catalytic residue: GLU 559;ASP 767;
references: 1dq8
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dq8
comment: invisible H866

1dq8C02
type: Pdb
catalytic residue: GLU 559;ASP 767;
references: 1dq8
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dq8
comment: invisible H866

1dq8D02
type: Pdb
catalytic residue: GLU 559;ASP 767;
references: 1dq8
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dq8
comment: invisible H866

1dqaA02
type: Pdb
catalytic residue: GLU 559;ASP 767;HIS 866
references: 1dqa
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dqa

1dqaB02
type: Pdb
catalytic residue: GLU 559;ASP 767;HIS 866
references: 1dqa
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dqa

1dqaC02
type: Pdb
catalytic residue: GLU 559;ASP 767;HIS 866
references: 1dqa
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dqa

1dqaD02
type: Pdb
catalytic residue: GLU 559;ASP 767;HIS 866
references: 1dqa
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dqa

1dq9A02
type: Pdb
catalytic residue: GLU 559;ASP 767;
references: 1dq9
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dq9
comment: invisible H866

1dq9B02
type: Pdb
catalytic residue: GLU 559;ASP 767;
references: 1dq9
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dq9
comment: invisible H866

1dq9C02
type: Pdb
catalytic residue: GLU 559;ASP 767;HIS 866
references: 1dq9
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dq9

1dq9D02
type: Pdb
catalytic residue: GLU 559;ASP 767;
references: 1dq9
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dq9
comment: invisible H866

1dqaA03
type: Pdb
catalytic residue: LYS 691
references: 1dqa
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dqa

1dqaB03
type: Pdb
catalytic residue: LYS 691
references: 1dqa
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dqa

1dqaC03
type: Pdb
catalytic residue: LYS 691
references: 1dqa
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dqa

1dqaD03
type: Pdb
catalytic residue: LYS 691
references: 1dqa
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dqa

1dq8A01
type: Pdb
references: 1dq8
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dq8
comment: mutant M485I

1dq8A03
type: Pdb
catalytic residue: LYS 691
references: 1dq8
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dq8

1dq8B01
type: Pdb
references: 1dq8
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dq8
comment: mutant M485I

1dq8B03
type: Pdb
catalytic residue: LYS 691
references: 1dq8
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dq8

1dq8C01
type: Pdb
references: 1dq8
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dq8
comment: mutant M485I

1dq8C03
type: Pdb
catalytic residue: LYS 691
references: 1dq8
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dq8

1dq8D01
type: Pdb
references: 1dq8
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dq8
comment: mutant M485I

1dq8D03
type: Pdb
catalytic residue: LYS 691
references: 1dq8
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dq8

1dq9A01
type: Pdb
references: 1dq9
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dq9
comment: mutant M485I

1dq9A03
type: Pdb
catalytic residue: LYS 691
references: 1dq9
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dq9

1dq9B01
type: Pdb
references: 1dq9
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dq9
comment: mutant M485I

1dq9B03
type: Pdb
catalytic residue: LYS 691
references: 1dq9
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dq9

1dq9C01
type: Pdb
references: 1dq9
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dq9
comment: mutant M485I

1dq9C03
type: Pdb
catalytic residue: LYS 691
references: 1dq9
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dq9

1dq9D01
type: Pdb
references: 1dq9
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dq9
comment: mutant M485I

1dq9D03
type: Pdb
catalytic residue: LYS 691
references: 1dq9
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dq9

1dqaA01
type: Pdb
references: 1dqa
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dqa
comment: mutant M485I

1dqaB01
type: Pdb
references: 1dqa
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dqa
comment: mutant M485I

1dqaC01
type: Pdb
references: 1dqa
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dqa
comment: mutant M485I

1dqaD01
type: Pdb
references: 1dqa
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dqa
comment: mutant M485I

1hw8A01
type: Pdb
references: 1hw8
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hw8
comment: mutant M485I

1hw8A02
type: Pdb
catalytic residue: GLU 559;ASP 767;
references: 1hw8
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hw8
comment: invisible H866

1hw8A03
type: Pdb
catalytic residue: LYS 691
references: 1hw8
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hw8

1hw8B01
type: Pdb
references: 1hw8
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hw8
comment: mutant M485I

1hw8B02
type: Pdb
catalytic residue: GLU 559;ASP 767;
references: 1hw8
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hw8
comment: invisible H866

1hw8B03
type: Pdb
catalytic residue: LYS 691
references: 1hw8
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hw8

1hw8C01
type: Pdb
references: 1hw8
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hw8
comment: mutant M485I

1hw8C02
type: Pdb
catalytic residue: GLU 559;ASP 767;
references: 1hw8
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hw8
comment: invisible H866

1hw8C03
type: Pdb
catalytic residue: LYS 691
references: 1hw8
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hw8

1hw8D01
type: Pdb
references: 1hw8
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hw8
comment: mutant M485I

1hw8D02
type: Pdb
catalytic residue: GLU 559;ASP 767;
references: 1hw8
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hw8
comment: invisible H866

1hw8D03
type: Pdb
catalytic residue: LYS 691
references: 1hw8
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hw8

1hw9A01
type: Pdb
references: 1hw9
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hw9
comment: mutant M485I

1hw9A02
type: Pdb
catalytic residue: GLU 559;ASP 767;
references: 1hw9
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hw9
comment: invisible H866

1hw9A03
type: Pdb
catalytic residue: LYS 691
references: 1hw9
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hw9

1hw9B01
type: Pdb
references: 1hw9
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hw9
comment: mutant M485I

1hw9B02
type: Pdb
catalytic residue: GLU 559;ASP 767;
references: 1hw9
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hw9
comment: invisible H866

1hw9B03
type: Pdb
catalytic residue: LYS 691
references: 1hw9
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hw9

1hw9C01
type: Pdb
references: 1hw9
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hw9
comment: mutant M485I

1hw9C02
type: Pdb
catalytic residue: GLU 559;ASP 767;
references: 1hw9
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hw9
comment: invisible H866

1hw9C03
type: Pdb
catalytic residue: LYS 691
references: 1hw9
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hw9

1hw9D01
type: Pdb
references: 1hw9
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hw9
comment: mutant M485I

1hw9D02
type: Pdb
catalytic residue: GLU 559;ASP 767;
references: 1hw9
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hw9
comment: invisible H866

1hw9D03
type: Pdb
catalytic residue: LYS 691
references: 1hw9
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hw9

1hwiA01
type: Pdb
references: 1hwi
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwi
comment: mutant M485I

1hwiA02
type: Pdb
catalytic residue: GLU 559;ASP 767;
references: 1hwi
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwi
comment: invisible H866

1hwiA03
type: Pdb
catalytic residue: LYS 691
references: 1hwi
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwi

1hwiB01
type: Pdb
references: 1hwi
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwi
comment: mutant M485I

1hwiB02
type: Pdb
catalytic residue: GLU 559;ASP 767;
references: 1hwi
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwi
comment: invisible H866

1hwiB03
type: Pdb
catalytic residue: LYS 691
references: 1hwi
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwi

1hwiC01
type: Pdb
references: 1hwi
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwi
comment: mutant M485I

1hwiC02
type: Pdb
catalytic residue: GLU 559;ASP 767;
references: 1hwi
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwi
comment: invisible H866

1hwiC03
type: Pdb
catalytic residue: LYS 691
references: 1hwi
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwi

1hwiD01
type: Pdb
references: 1hwi
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwi
comment: mutant M485I

1hwiD02
type: Pdb
catalytic residue: GLU 559;ASP 767;
references: 1hwi
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwi
comment: invisible H866

1hwiD03
type: Pdb
catalytic residue: LYS 691
references: 1hwi
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwi

1hwjA01
type: Pdb
references: 1hwj
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwj
comment: mutant M485I

1hwjA02
type: Pdb
catalytic residue: GLU 559;ASP 767;
references: 1hwj
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwj
comment: invisible H866

1hwjA03
type: Pdb
catalytic residue: LYS 691
references: 1hwj
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwj

1hwjB01
type: Pdb
references: 1hwj
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwj
comment: mutant M485I

1hwjB02
type: Pdb
catalytic residue: GLU 559;ASP 767;
references: 1hwj
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwj
comment: invisible H866

1hwjB03
type: Pdb
catalytic residue: LYS 691
references: 1hwj
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwj

1hwjC01
type: Pdb
references: 1hwj
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwj
comment: mutant M485I

1hwjC02
type: Pdb
catalytic residue: GLU 559;ASP 767;
references: 1hwj
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwj
comment: invisible H866

1hwjC03
type: Pdb
catalytic residue: LYS 691
references: 1hwj
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwj

1hwjD01
type: Pdb
references: 1hwj
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwj
comment: mutant M485I

1hwjD02
type: Pdb
catalytic residue: GLU 559;ASP 767;
references: 1hwj
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwj
comment: invisible H866

1hwjD03
type: Pdb
catalytic residue: LYS 691
references: 1hwj
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwj

1hwkA01
type: Pdb
references: 1hwk
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwk
comment: mutant M485I

1hwkA02
type: Pdb
catalytic residue: GLU 559;ASP 767;
references: 1hwk
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwk
comment: invisible H866

1hwkA03
type: Pdb
catalytic residue: LYS 691
references: 1hwk
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwk

1hwkB01
type: Pdb
references: 1hwk
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwk
comment: mutant M485I

1hwkB02
type: Pdb
catalytic residue: GLU 559;ASP 767;
references: 1hwk
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwk
comment: invisible H866

1hwkB03
type: Pdb
catalytic residue: LYS 691
references: 1hwk
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwk

1hwkC01
type: Pdb
references: 1hwk
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwk
comment: mutant M485I

1hwkC02
type: Pdb
catalytic residue: GLU 559;ASP 767;
references: 1hwk
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwk
comment: invisible H866

1hwkC03
type: Pdb
catalytic residue: LYS 691
references: 1hwk
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwk

1hwkD01
type: Pdb
references: 1hwk
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwk
comment: mutant M485I

1hwkD02
type: Pdb
catalytic residue: GLU 559;ASP 767;
references: 1hwk
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwk
comment: invisible H866

1hwkD03
type: Pdb
catalytic residue: LYS 691
references: 1hwk
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwk

1hwlA01
type: Pdb
references: 1hwl
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwl
comment: mutant M485I

1hwlA02
type: Pdb
catalytic residue: GLU 559;ASP 767;
references: 1hwl
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwl
comment: invisible H866

1hwlA03
type: Pdb
catalytic residue: LYS 691
references: 1hwl
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwl

1hwlB01
type: Pdb
references: 1hwl
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwl
comment: mutant M485I

1hwlB02
type: Pdb
catalytic residue: GLU 559;ASP 767;
references: 1hwl
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwl
comment: invisible H866

1hwlB03
type: Pdb
catalytic residue: LYS 691
references: 1hwl
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwl

1hwlC01
type: Pdb
references: 1hwl
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwl
comment: mutant M485I

1hwlC02
type: Pdb
catalytic residue: GLU 559;ASP 767;
references: 1hwl
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwl
comment: invisible H866

1hwlC03
type: Pdb
catalytic residue: LYS 691
references: 1hwl
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwl

1hwlD01
type: Pdb
references: 1hwl
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwl
comment: mutant M485I

1hwlD02
type: Pdb
catalytic residue: GLU 559;ASP 767;
references: 1hwl
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwl
comment: invisible H866

1hwlD03
type: Pdb
catalytic residue: LYS 691
references: 1hwl
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1hwl

CoA
type: KeggProduct
compound type: amine group
compound type: carbohydrate
compound type: nucleotide
compound type: peptide/protein
compound type: sulfhydryl group
references: KEGG:C00010
references: CHEBI:15346
references: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi

(R)-Mevalonate
type: KeggProduct
compound type: carbohydrate
compound type: carboxyl group
references: KEGG:C00418
references: CHEBI:17710
references: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi

NADP+
type: KeggProduct
compound type: amide group
compound type: amine group
compound type: nucleotide
references: KEGG:C00006
references: CHEBI:18009
references: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi

(S)-3-Hydroxy-3-methylglutaryl-CoA
type: KeggSubstrate
compound type: amine group
compound type: carbohydrate
compound type: carboxyl group
compound type: nucleotide
compound type: peptide/protein
compound type: sulfide group
references: KEGG:C00356
references: CHEBI:15467
references: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi

NADPH
type: KeggSubstrate
compound type: amide group
compound type: amine group
compound type: nucleotide
references: KEGG:C00005
references: CHEBI:16474
references: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi

Mevaldyl-CoA
type: KeggIntermediate
references: KEGG:I00101

Mevaldehyde
type: KeggIntermediate
references: KEGG:I00102

hydroxymethylglutaryl coenzyme A reductase (reduced nicotinamideadenine dinucleotide phosphate)
type: KeggEnzyme

3-hydroxy-3-methylglutaryl-CoA reductase
type: KeggEnzyme

beta-hydroxy-beta-methylglutaryl coenzyme A reductase
type: KeggEnzyme

hydroxymethylglutaryl CoA reductase (NADPH)
type: KeggEnzyme

S-3-hydroxy-3-methylglutaryl-CoA reductase
type: KeggEnzyme

NADPH-hydroxymethylglutaryl-CoA reductase
type: KeggEnzyme

HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating-CoA)
type: KeggEnzyme

3-hydroxy-3-methylglutaryl CoA reductase (NADPH)
type: KeggEnzyme

hydroxymethylglutaryl-CoA reductase (NADPH2)
type: KeggEnzyme