@prefix chebi: <http://identifiers.org/CHEBI:> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix ezdb_cath: <http://ezcatdb.cbrc.jp/EzCatDB/cath/> .
@prefix ezdb_compound: <http://ezcatdb.cbrc.jp/EzCatDB/compound/> .
@prefix ezdb_pathway: <http://ezcatdb.cbrc.jp/EzCatDB/pathway/> .
@prefix ezdb_pdb: <http://ezcatdb.cbrc.jp/EzCatDB/pdb/> .
@prefix ezdb_ref: <http://ezcatdb.cbrc.jp/EzCatDB/reference/> .
@prefix ezdbo: <http://ezcatdb.cbrc.jp/EzCatDB/ontology/> .
@prefix kegg: <http://identifiers.org/KEGG:> .
@prefix pdb: <http://identifiers.org/PDB:> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix up: <https://purl.uniprot.org/uniprot/> .
@prefix up_enzyme: <https://purl.uniprot.org/enzyme/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<http://ezcatdb.cbrc.jp/EzCatDB/EzCatDB/enzyme/D00880> a ezdbo:Enzyme;
  rdfs:label "D00880";
  ezdbo:active_site_residues_resources ezdb_ref:D00880\#3,
    ezdb_ref:D00880\#4;
  ezdbo:cath <http://ezcatdb.cbrc.jp/EzCatDB/cath/-.-.-.->,
    ezdb_cath:3\.90\.79\.10;
  ezdbo:ec up_enzyme:3\.6\.1\.13;
  ezdbo:kegg_cofactor ezdb_compound:C00305;
  ezdbo:kegg_enzyme [
    a ezdbo:KeggEnzyme;
    rdfs:label "ADP-ribose diphosphatase"
  ], [
    a ezdbo:KeggEnzyme;
    rdfs:label "ADPribose pyrophosphatase"
  ], [
    a ezdbo:KeggEnzyme;
    rdfs:label "Adenosine diphosphoribose pyrophosphatase"
  ], [
    a ezdbo:KeggEnzyme;
    rdfs:label "ADPR-PPase"
  ];
  ezdbo:kegg_pathway ezdb_pathway:MAP00230;
  ezdbo:kegg_product ezdb_compound:C00020,
    ezdb_compound:C00117;
  ezdbo:kegg_substrate ezdb_compound:C00301,
    ezdb_compound:C00001;
  ezdbo:pdb ezdb_pdb:1q33A01,
    ezdb_pdb:1qvjA01,
    ezdb_pdb:1q33A02,
    ezdb_pdb:1qvjA02;
  ezdbo:pdb_bound_state [
    a ezdbo:Unbound;
    ezdbo:compound ezdb_compound:C00301;
    ezdbo:pdb ezdb_pdb:1q33A01
  ], [
    a ezdbo:Unbound;
    ezdbo:compound ezdb_compound:C00301;
    ezdbo:pdb ezdb_pdb:1qvjA01
  ], [
    a ezdbo:Unbound;
    ezdbo:compound ezdb_compound:C00301;
    ezdbo:pdb ezdb_pdb:1q33A02
  ], [
    a ezdbo:Unbound;
    ezdbo:compound ezdb_compound:C00301;
    ezdbo:pdb ezdb_pdb:1qvjA02
  ], [
    a ezdbo:Unbound;
    ezdbo:compound ezdb_compound:C00305;
    ezdbo:pdb ezdb_pdb:1q33A01
  ], [
    a ezdbo:Unbound;
    ezdbo:compound ezdb_compound:C00305;
    ezdbo:pdb ezdb_pdb:1qvjA01
  ], [
    a ezdbo:Unbound;
    ezdbo:compound ezdb_compound:C00305;
    ezdbo:pdb ezdb_pdb:1q33A02
  ], [
    a ezdbo:Unbound;
    ezdbo:compound ezdb_compound:C00020;
    ezdbo:pdb ezdb_pdb:1q33A01
  ], [
    a ezdbo:Unbound;
    ezdbo:compound ezdb_compound:C00020;
    ezdbo:pdb ezdb_pdb:1qvjA01
  ], [
    a ezdbo:Unbound;
    ezdbo:compound ezdb_compound:C00020;
    ezdbo:pdb ezdb_pdb:1q33A02
  ], [
    a ezdbo:Unbound;
    ezdbo:compound ezdb_compound:C00020;
    ezdbo:pdb ezdb_pdb:1qvjA02
  ], [
    a ezdbo:Unbound;
    ezdbo:compound ezdb_compound:C00117;
    ezdbo:pdb ezdb_pdb:1q33A01
  ], [
    a ezdbo:Unbound;
    ezdbo:compound ezdb_compound:C00117;
    ezdbo:pdb ezdb_pdb:1qvjA01
  ];
  ezdbo:reference_for_catalytic_mechanism [
    a ezdbo:ReferenceForCatalyticMechanism;
    ezdbo:reference_index 2;
    ezdbo:reference_section "Figure 6"
  ], [
    a ezdbo:ReferenceForCatalyticMechanism;
    ezdbo:reference_index 3;
    ezdbo:reference_section "p.391-395"
  ];
  ezdbo:rlcp <http://ezcatdb.cbrc.jp/EzCatDB/RLCP/r1/l15/c9995/p1169>;
  ezdbo:uniprot up:Q9BW91;
  dcterms:references ezdb_ref:D00880\#1,
    ezdb_ref:D00880\#2,
    ezdb_ref:D00880\#3,
    ezdb_ref:D00880\#4,
    ezdb_ref:D00880\#5,
    ezdb_ref:D00880\#6,
    ezdb_ref:D00880\#7,
    ezdb_ref:D00880\#8,
    ezdb_ref:D00880\#9,
    ezdb_ref:D00880\#10,
    ezdb_ref:D00880\#11;
  rdfs:comment """This enzyme belongs to Nudix (nucleoside diphosphate linked to x) hydrolase family.
There are several types of ADP-ribose pyrophosphatases from various organisms (<a href=\"../search/get.do?dbcode=S00814\">S00814</a>, <a href=\"../search/get.do?dbcode=S00921\">S00921</a>, <a href=\"../search/get.do?dbcode=S00922\">S00922</a>, <a href=\"../search/get.do?dbcode=S00923\">S00923</a>, <a href=\"../search/get.do?dbcode=S00924\">S00924</a>, D00880 in EzCatDB), in terms of substrate specificities, metal binding, active-sites and reaction mechanisms. Among these homologous enzymes, the homologue from E. coli (<a href=\"../search/get.do?dbcode=S00814\">S00814</a> in EzCatDB) is the closest one (see [3]).
Although Asp305 is at the same position of Glu162, which acts as a general base to activate the hydrolytic water, from E.coli homologous enzyme (<a href=\"../search/get.do?dbcode=S00814\">S00814</a>), mutant of Asp305 does not reduce the catalytic activity drastically, indicating that this residue may not be a general base (see [3]). Asp305 may participate in orientation of one or two metal ions and the hydrolytic water that is bound to the metal ions (see [3]).
According to the literature [2] and [3], the reaction may proceed as follows:""" .

<http://ezcatdb.cbrc.jp/EzCatDB/cath/-.-.-.-> a ezdbo:Cath;
  rdfs:label "";
  dcterms:identifier "-.-.-.-";
  dcterms:references <http://www.cathdb.info/version/latest/superfamily/-.-.-.-> .

ezdb_cath:3\.90\.79\.10 a ezdbo:Cath;
  rdfs:label "Nucleoside Triphosphate Pyrophosphohydrolase";
  ezdbo:catalytic_domain <http://ezcatdb.cbrc.jp/EzCatDB//CatDom/c3/a90/t79/h10/index.html>;
  dcterms:identifier "3.90.79.10";
  dcterms:references <http://www.cathdb.info/version/latest/superfamily/3.90.79.10> .

ezdb_compound:C00001 a ezdbo:KeggSubstrate;
  rdfs:label "H2O";
  ezdbo:compound_type "H2O";
  dcterms:identifier "C00001";
  dcterms:references kegg:C00001,
    chebi:15377,
    <http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=22247451>,
    <http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=962> .

ezdb_pathway:MAP00230 a ezdbo:KeggPathway;
  rdfs:label "Purine metabolism";
  dcterms:identifier "MAP00230";
  dcterms:references kegg:MAP00230 .

ezdb_ref:D00880\#1 a dcterms:BibliographicResource;
  dcterms:title "The structure of ADP-ribose pyrophosphatase reveals the structural basis for the versatility of the Nudix family.";
  ezdbo:authors [
    a rdf:Seq;
    rdf:_1 "Gabelli SB";
    rdf:_2 "Bianchet MA";
    rdf:_3 "Bessman MJ";
    rdf:_4 "Amzel LM"
  ];
  ezdbo:journal "Nat Struct Biol";
  ezdbo:pages "467-72";
  ezdbo:published_year 2001;
  ezdbo:volume "8";
  dcterms:references <http://www.ncbi.nlm.nih.gov/pubmed/11323725>,
    <http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1g0s>,
    <http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1g9q>,
    <http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1ga7>,
    up:Q93K97;
  rdfs:comment "X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF NATIVE ENZYME, COMPLEX WITH ADP-RIBOSE, COMPLEX WITH GADOLINIUM." .

ezdb_ref:D00880\#10 a dcterms:BibliographicResource;
  dcterms:title "Molecular mechanism of ADP-ribose hydrolysis by human NUDT5 from structural and kinetic studies.";
  ezdbo:authors [
    a rdf:Seq;
    rdf:_1 "Zha M";
    rdf:_2 "Guo Q";
    rdf:_3 "Zhang Y";
    rdf:_4 "Yu B";
    rdf:_5 "Ou Y";
    rdf:_6 "Zhong C";
    rdf:_7 "Ding J"
  ];
  ezdbo:journal "J Mol Biol";
  ezdbo:pages "568-78";
  ezdbo:published_year 2008;
  ezdbo:volume "379";
  dcterms:references <http://www.ncbi.nlm.nih.gov/pubmed/18462755>,
    <http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=3bm4> .

ezdb_ref:D00880\#11 a dcterms:BibliographicResource;
  dcterms:title "Diverse substrate recognition and hydrolysis mechanisms of human NUDT5.";
  ezdbo:authors [
    a rdf:Seq;
    rdf:_1 "Arimori T";
    rdf:_10 "Yamagata Y";
    rdf:_2 "Tamaoki H";
    rdf:_3 "Nakamura T";
    rdf:_4 "Kamiya H";
    rdf:_5 "Ikemizu S";
    rdf:_6 "Takagi Y";
    rdf:_7 "Ishibashi T";
    rdf:_8 "Harashima H";
    rdf:_9 "Sekiguchi M"
  ];
  ezdbo:journal "Nucleic Acids Res";
  ezdbo:pages "8972-83";
  ezdbo:published_year 2011;
  ezdbo:volume "39";
  dcterms:references <http://www.ncbi.nlm.nih.gov/pubmed/21768126>,
    <http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=3ac9>,
    <http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=3aca>,
    <http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=3l85> .

ezdb_ref:D00880\#2 a dcterms:BibliographicResource;
  dcterms:title "Mechanism of the Escherichia coli ADP-ribose pyrophosphatase, a Nudix hydrolase.";
  ezdbo:authors [
    a rdf:Seq;
    rdf:_1 "Gabelli SB";
    rdf:_2 "Bianchet MA";
    rdf:_3 "Ohnishi Y";
    rdf:_4 "Ichikawa Y";
    rdf:_5 "Bessman MJ";
    rdf:_6 "Amzel LM"
  ];
  ezdbo:journal "Biochemistry";
  ezdbo:pages "9279-85";
  ezdbo:published_year 2002;
  ezdbo:volume "41";
  dcterms:references <http://www.ncbi.nlm.nih.gov/pubmed/12135348>,
    <http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1khz>,
    up:Q93K97;
  rdfs:comment "X-RAY CRYSTALLOGRAPHY (2.07 ANGSTROMS), CATALYTIC MECHANISM." .

ezdb_ref:D00880\#5 a dcterms:BibliographicResource;
  dcterms:title "Structural insights into the Thermus thermophilus ADP-ribose pyrophosphatase mechanism via crystal structures with the bound substrate and metal.";
  ezdbo:authors [
    a rdf:Seq;
    rdf:_1 "Yoshiba S";
    rdf:_2 "Ooga T";
    rdf:_3 "Nakagawa N";
    rdf:_4 "Shibata T";
    rdf:_5 "Inoue Y";
    rdf:_6 "Yokoyama S";
    rdf:_7 "Kuramitsu S";
    rdf:_8 "Masui R"
  ];
  ezdbo:journal "J Biol Chem";
  ezdbo:pages "37163-74";
  ezdbo:published_year 2004;
  ezdbo:volume "279";
  dcterms:references <http://www.ncbi.nlm.nih.gov/pubmed/15210687>,
    <http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1v8i>,
    <http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1v8l>,
    <http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1v8m>,
    <http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1v8n>,
    <http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1v8r>,
    <http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1v8s>,
    <http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1v8t>,
    <http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1v8u>,
    <http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1v8v>,
    <http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1v8w>,
    <http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1v8y> .

ezdb_ref:D00880\#6 a dcterms:BibliographicResource;
  dcterms:title "Structures and mechanisms of Nudix hydrolases.";
  ezdbo:authors [
    a rdf:Seq;
    rdf:_1 "Mildvan AS";
    rdf:_10 "Amzel LM";
    rdf:_2 "Xia Z";
    rdf:_3 "Azurmendi HF";
    rdf:_4 "Saraswat V";
    rdf:_5 "Legler PM";
    rdf:_6 "Massiah MA";
    rdf:_7 "Gabelli SB";
    rdf:_8 "Bianchet MA";
    rdf:_9 "Kang LW"
  ];
  ezdbo:journal "Arch Biochem Biophys";
  ezdbo:pages "129-43";
  ezdbo:published_year 2005;
  ezdbo:volume "433";
  dcterms:references <http://www.ncbi.nlm.nih.gov/pubmed/15581572> .

ezdb_ref:D00880\#7 a dcterms:BibliographicResource;
  dcterms:title "Molecular mechanism of the Thermus thermophilus ADP-ribose pyrophosphatase from mutational and kinetic studies.";
  ezdbo:authors [
    a rdf:Seq;
    rdf:_1 "Ooga T";
    rdf:_2 "Yoshiba S";
    rdf:_3 "Nakagawa N";
    rdf:_4 "Kuramitsu S";
    rdf:_5 "Masui R"
  ];
  ezdbo:journal "Biochemistry";
  ezdbo:pages "9320-9";
  ezdbo:published_year 2005;
  ezdbo:volume "44";
  dcterms:references <http://www.ncbi.nlm.nih.gov/pubmed/15981998> .

ezdb_ref:D00880\#8 a dcterms:BibliographicResource;
  dcterms:title "Crystal structures of human NUDT5 reveal insights into the structural basis of the substrate specificity.";
  ezdbo:authors [
    a rdf:Seq;
    rdf:_1 "Zha M";
    rdf:_2 "Zhong C";
    rdf:_3 "Peng Y";
    rdf:_4 "Hu H";
    rdf:_5 "Ding J"
  ];
  ezdbo:journal "J Mol Biol";
  ezdbo:pages "1021-33";
  ezdbo:published_year 2006;
  ezdbo:volume "364";
  dcterms:references <http://www.ncbi.nlm.nih.gov/pubmed/17052728>,
    <http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=2dsb>,
    <http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=2dsc>,
    <http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=2dsd> .

ezdb_ref:D00880\#9 a dcterms:BibliographicResource;
  dcterms:title "Structural basis for different substrate specificities of two ADP-ribose pyrophosphatases from Thermus thermophilus HB8.";
  ezdbo:authors [
    a rdf:Seq;
    rdf:_1 "Wakamatsu T";
    rdf:_2 "Nakagawa N";
    rdf:_3 "Kuramitsu S";
    rdf:_4 "Masui R"
  ];
  ezdbo:journal "J Bacteriol";
  ezdbo:pages "1108-17";
  ezdbo:published_year 2008;
  ezdbo:volume "190";
  dcterms:references <http://www.ncbi.nlm.nih.gov/pubmed/18039767> .

ezdb_ref:D00880\#3 a dcterms:BibliographicResource;
  dcterms:title "The crystal structure and mutational analysis of human NUDT9.";
  ezdbo:authors [
    a rdf:Seq;
    rdf:_1 "Shen BW";
    rdf:_2 "Perraud AL";
    rdf:_3 "Scharenberg A";
    rdf:_4 "Stoddard BL"
  ];
  ezdbo:journal "J Mol Biol";
  ezdbo:pages "385-98";
  ezdbo:published_year 2003;
  ezdbo:volume "332";
  dcterms:references <http://www.ncbi.nlm.nih.gov/pubmed/12948489>,
    <http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1q33>,
    <http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1qvj> .

ezdb_ref:D00880\#4 a dcterms:BibliographicResource;
  dcterms:title "Structure and mechanism of MT-ADPRase, a nudix hydrolase from Mycobacterium tuberculosis.";
  ezdbo:authors [
    a rdf:Seq;
    rdf:_1 "Kang LW";
    rdf:_2 "Gabelli SB";
    rdf:_3 "Cunningham JE";
    rdf:_4 "O'Handley SF";
    rdf:_5 "Amzel LM"
  ];
  ezdbo:journal "Structure";
  ezdbo:pages "1015-23";
  ezdbo:published_year 2003;
  ezdbo:volume "11";
  dcterms:references <http://www.ncbi.nlm.nih.gov/pubmed/12906832>,
    <http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1mk1>,
    <http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1mp2>,
    <http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1mqe>,
    <http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1mqw>,
    <http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1mr2> .

ezdb_compound:C00117 a ezdbo:KeggProduct;
  rdfs:label "D-ribose 5-phosphate";
  ezdbo:compound_type "carbohydrate",
    "phosphate group/phosphate ion";
  dcterms:identifier "C00117";
  dcterms:references kegg:C00117,
    chebi:52742,
    <http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=439167> .

ezdb_pdb:1qvjA02 a ezdbo:Pdb;
  ezdbo:catalytic_residue "ARG 204;ARG 273;ASP 305";
  ezdbo:cofactor_binding_residue "GLY 214(Magnesium-2);GLU 230(Magnesium-1)";
  dcterms:identifier "1qvjA02";
  dcterms:references <https://pdbj.org/mine/summary/1qvj>,
    <http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1qvj>,
    pdb:1qvj .

ezdb_compound:C00305 a ezdbo:KeggCofactor;
  rdfs:label "Magnesium";
  ezdbo:compound_type "divalent metal (Ca2+, Mg2+)";
  dcterms:identifier "C00305";
  dcterms:references kegg:C00305,
    chebi:18420,
    <http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=888> .

ezdb_pdb:1q33A02 a ezdbo:Pdb;
  ezdbo:catalytic_residue "ARG 204;ARG 273;ASP 305";
  ezdbo:cofactor_binding_residue "GLY 214(Magnesium-2);GLU 230(Magnesium-1)";
  dcterms:identifier "1q33A02";
  dcterms:references <https://pdbj.org/mine/summary/1q33>,
    <http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1q33>,
    pdb:1q33 .

ezdb_compound:C00020 a ezdbo:KeggProduct;
  rdfs:label "AMP";
  ezdbo:compound_type "amine group",
    "nucleotide ";
  dcterms:identifier "C00020";
  dcterms:references kegg:C00020,
    chebi:16027,
    <http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6083> .

ezdb_compound:C00301 a ezdbo:KeggSubstrate;
  rdfs:label "ADP-ribose";
  ezdbo:compound_type "amine group",
    "carbohydrate",
    "nucleotide ";
  dcterms:identifier "C00301";
  dcterms:references kegg:C00301,
    <http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=445794> .

ezdb_pdb:1q33A01 a ezdbo:Pdb;
  dcterms:identifier "1q33A01";
  dcterms:references <https://pdbj.org/mine/summary/1q33>,
    <http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1q33>,
    pdb:1q33 .

ezdb_pdb:1qvjA01 a ezdbo:Pdb;
  dcterms:identifier "1qvjA01";
  dcterms:references <https://pdbj.org/mine/summary/1qvj>,
    <http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1qvj>,
    pdb:1qvj .